Ligand Gly-Gly

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Basic Ligand Information

Molecular Structure
Picture of Gly-Gly (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C4H8N2O3
Gly-Gly
YMAWOPBAYDPSLA-UHFFFAOYSA-N
Synonyms:
diglycine, GG, glycyl-glycine, glycylglycine, Glycylglycine buffer

Roles as Enzyme Ligand

In Vivo Product in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
Z-Gly-Pro-Gly-Gly-Pro-Ala + H2O = Z-Gly-Pro + Gly-Gly + L-Pro-L-Ala
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pentaglycine + H2O = diglycine + triglycine
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Substrate in Enzyme-catalyzed Reactions (77 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
glycylglycine + H2O + O2 = ?
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streptidine phosphate + glycylglycine = ?
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Gly-Gly + H2O = Gly + Gly
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Gly-Gly + H2O = Gly + Gly
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Gly-Gly + H2O = Gly + Gly
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Gly-Gly + H2O = Gly + Gly
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Gly-Gly + H2O = Gly + Gly
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Gly-Gly + H2O = Gly-Gly-Gly-Gly
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Gly-Gly + H2O = ?
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ATP + H2O + Gly-Gly/in = ADP + phosphate + Gly-Gly/out
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Product in Enzyme-catalyzed Reactions (70 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
5-L-glutamyglycylglycine + acceptor = glycylglycine + 5-L-glutamyl-acceptor
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Glcbeta(1-4)Glcbeta(1-4)Glcbeta(1-4)Glcbeta(1-4)Glc + H2O = Glcbeta(1-4)Glcbeta(1-4)Glc + GG
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Met-Gly-Gly + H2O = Met + Gly-Gly
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D-Ala-Gly-Gly + H2O = D-Ala + Gly-Gly
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Xaa-Gly-Gly + H2O = Xaa + Gly-Gly
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Leu-Gly-Gly + H2O = Leu + Gly-Gly
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Pro-Gly-Gly + H2O = Pro + Gly-Gly
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Gly-Pro-Gly-Gly + H2O = Gly-Pro + Gly-Gly
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Gly-Pro-Gly-Gly + H2O = Gly-Pro + Gly-Gly
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Gly-Gly-Gly-Gly + H2O = Gly-Gly
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Gly-Gly-Phe-Ala + H2O = Gly-Gly + Phe-Ala
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Gly-Gly-Arg + H2O = Gly-Gly + Arg
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beta-Asp-Gly-Gly + H2O = Asp + Gly-Gly
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Z-Gly-Pro-Gly-Gly-Pro-Ala + H2O = Z-Gly-Pro + Gly-Gly + L-Pro-L-Ala
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pentaglycine + H2O = diglycine + triglycine
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Gly-Gly-Phe-Leu + H2O = Gly-Gly + Phe-Leu
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Gly-Gly-Phe-Met + H2O = Gly-Gly + Phe-Met
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glycylglycylglycine + H2O = glycine + glycylglycine
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2,5-dioxopiperazine + H2O = glycylglycine
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ATP + H2O + Gly-Gly/in = ADP + phosphate + Gly-Gly/out
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Activator in Enzyme-catalyzed Reactions (9 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
enhances activity
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activates enzyme form A and B
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Inhibitor in Enzyme-catalyzed Reactions (20 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
slightly inhibiting as buffer at 50 mM
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0.75 M
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5 mM, 8% inhibition
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200 mM, 50% inhibition
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competitive inhibitor, Ki: 5 mM
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higher inhibition at pH 7.8 than at pH 6.5
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Enzyme Kinetic Parameters

kcat Value (Turnover Number) (2 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE

KM Value (25 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
11.2
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His-tagged recombinant enzyme, 37°C
10.1
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References & Links

Links to other databases for Gly-Gly

ChEBI
PubChem
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PubChem