Reference on EC 7.6.2.9 - ABC-type quaternary amine transporter
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Barron, A.; Jung, J.U.; Villarejo, M.
Purification and characterization of a glycine betaine binding protein from Escherichia coli
J. Biol. Chem.
262
11841-11846
1987
Escherichia coli
Van der Heide, T.; Poolman, B.
Osmoregulated ABC-transport system of Lactococcus lactis senses water stress via changes in the physical state of the membrane
Proc. Natl. Acad. Sci. USA
97
7102-7106
2000
Bacillus subtilis, Lactococcus lactis, Lactococcus lactis OpuA
May, G.; Faatz, E.; Villarejo, M.; Bremer, E.
Binding protein dependent transport of glycine betaine and its osmotic regulation in Escherichia coli K12
Mol. Gen. Genet.
205
225-233
1986
Escherichia coli
Kempf, B.; Bremer, E.
OpuA, an osmotically regulated binding protein-dependent transport system for the osmoprotectant glycine betaine in Bacillus subtilis
J. Biol. Chem.
270
16701-16713
1995
Bacillus subtilis, Bacillus subtilis OpuA
Kempf, B.; Gade, J.; Bremer, E.
Lipoprotein from the osmoregulated ABC transport system OpuA of Bacillus subtilis: purification of the glycine betaine binding protein and characterization of a functional lipidless mutant
J. Bacteriol.
179
6213-6220
1997
Bacillus subtilis
Obis, D.; Guillot, A.; Gripon, J.C.; Renault, P.; Bolotin, A.; Mistou, M.Y.
Genetic and biochemical characterization of a high-affinity betaine uptake system (BusA) in Lactococcus lactis reveals a new functional organization within bacterial ABC transporters
J. Bacteriol.
181
6238-6246
1999
Lactococcus lactis, Lactococcus lactis OpuA
Gerhardt, P.N.; Tombras Smith, L.; Smith, G.M.
Osmotic and chill activation of glycine betaine porter II in Listeria monocytogenes membrane vesicles
J. Bacteriol.
182
2544-2550
2000
Listeria monocytogenes
Ko, R.; Smith, L.T.
Identification of an ATP-driven, osmoregulated glycine betaine transport system in Listeria monocytogenes
Appl. Environ. Microbiol.
65
4040-4048
1999
Listeria monocytogenes
Kappes, R.M.; Kempf, B.; Bremer, E.
Three transport systems for the osmoprotectant glycine betaine operate in Bacillus subtilis: characterization of OpuD
J. Bacteriol.
178
5071-5079
1996
Bacillus subtilis
van der Heide, T.; Stuart, M.C.A.; Poolman, B.
On the osmotic signal and osmosensing mechanism of an ABC transport system for glycine betaine
EMBO J.
20
7022-7032
2001
Lactococcus lactis
Biemans-Oldehinkel, E.; Poolman, B.
On the role of the two extracytoplasmic substrate-binding domains in the ABC transporter OpuA
EMBO J.
22
5983-5993
2003
Lactococcus lactis, Lactococcus lactis NZ9000
Horn, C.; Bremer, E.; Schmitt, L.
Nucleotide dependent monomer/dimer equilibrium of OpuAA, the nucleotide-binding protein of the osmotically regulated ABC transporter OpuA from Bacillus subtilis
J. Mol. Biol.
334
403-419
2003
Bacillus subtilis
Patzlaff, J.S.; van der Heide, T.; Poolman, B.
The ATP/substrate stoichiometry of the ATP-binding cassette (ABC) transporter OpuA
J. Biol. Chem.
278
29546-29551
2003
Lactococcus lactis, Lactococcus lactis NZ9000
Romeo, Y.; Obis, D.; Bouvier, J.; Guillot, A.; Fourans, A.; Bouvier, I.; Gutierrez, C.; Mistou, MY.
Osmoregulation in Lactococcus lactis: BusR, a transcriptional repressor of the glycine betaine uptake system BusA
Mol. Microbiol.
47
1135-1147
2003
Lactococcus lactis
Wemekamp-Kamphuis, H.H.; Sleator, R.D.; Wouters, J.A.; Hill, C.; Abee, T.
Molecular and physiological analysis of the role of osmolyte transporters BetL, Gbu, and OpuC in growth of Listeria monocytogenes at low temperatures
Appl. Environ. Microbiol.
70
2912-2918
2004
Listeria monocytogenes, Listeria monocytogenes LO28
Laloknam, S.; Tanaka, K.; Buaboocha, T.; Waditee, R.; Incharoensakdi, A.; Hibino, T.; Tanaka, Y.; Takabe, T.
Halotolerant cyanobacterium Aphanothece halophytica contains a betaine transporter active at alkaline pH and high salinity
Appl. Environ. Microbiol.
72
6018-6026
2006
Aphanothece halophytica (Q0PCR9)
Horn, C.; Bremer, E.; Schmitt, L.
Functional overexpression and in vitro re-association of OpuA, an osmotically regulated ABC-transport complex from Bacillus subtilis
FEBS Lett.
579
5765-5768
2005
Bacillus subtilis
Holtmann, G.; Bremer, E.
Thermoprotection of Bacillus subtilis by exogenously provided glycine betaine and structurally related compatible solutes: involvement of Opu transporters
J. Bacteriol.
186
1683-1693
2004
Bacillus subtilis
Cetin, M.S.; Zhang, C.; Hutkins, R.W.; Benson, A.K.
Regulation of transcription of compatible solute transporters by the general stress sigma factor, sigmaB, in Listeria monocytogenes
J. Bacteriol.
186
794-802
2004
Listeria monocytogenes, Listeria monocytogenes 10403S
Mahmood, N.A.; Biemans-Oldehinkel, E.; Patzlaff, J.S.; Schuurman-Wolters, G.K.; Poolman, B.
Ion specificity and ionic strength dependence of the osmoregulatory ABC transporter OpuA
J. Biol. Chem.
281
29830-29839
2006
Lactococcus lactis (Q9KIF7), Lactococcus lactis, Lactococcus lactis IL1403 (Q9KIF7)
Horn, C.; Sohn-Boesser, L.; Breed, J.; Welte, W.; Schmitt, L.; Bremer, E.
Molecular determinants for substrate specificity of the ligand-binding protein OpuAC from Bacillus subtilis for the compatible solutes glycine betaine and proline betaine
J. Mol. Biol.
357
592-606
2006
Bacillus subtilis
Horn, C.; Jenewein, S.; Sohn-Boesser, L.; Bremer, E.; Schmitt, L.
Biochemical and structural analysis of the Bacillus subtilis ABC transporter OpuA and its isolated subunits
J. Mol. Microbiol. Biotechnol.
10
76-91
2005
Bacillus subtilis, Lactococcus lactis
Chen, C.; Beattie, G.A.
Characterization of the osmoprotectant transporter OpuC from Pseudomonas syringae and demonstration that cystathionine-beta-synthase domains are required for its osmoregulatory function
J. Bacteriol.
189
6901-6912
2007
Pseudomonas syringae (Q87WH5)
Horn, C.; Jenewein, S.; Tschapek, B.; Bouschen, W.; Metzger, S.; Bremer, E.; Schmitt, L.
Monitoring conformational changes during the catalytic cycle of OpuAA, the ATPase subunit of the ABC transporter OpuA from Bacillus subtilis
Biochem. J.
412
233-244
2008
Bacillus subtilis (P46920), Bacillus subtilis
Dreux, N.; Albagnac, C.; Sleator, R.D.; Hill, C.; Carlin, F.; Morris, C.E.; Nguyen-the, C.
Glycine betaine improves Listeria monocytogenes tolerance to desiccation on parsley leaves independent of the osmolyte transporters BetL, Gbu and OpuC
J. Appl. Microbiol.
104
1221-1227
2008
Listeria monocytogenes, Listeria monocytogenes LO28
Smits, S.H.; Hoeing, M.; Lecher, J.; Jebbar, M.; Schmitt, L.; Bremer, E.
The compatible-solute-binding protein OpuAC from Bacillus subtilis: ligand binding, site-directed mutagenesis, and crystallographic studies
J. Bacteriol.
190
5663-5671
2008
Bacillus subtilis (P46922), Bacillus subtilis
Du, Y.; Shi, W.W.; He, Y.X.; Yang, Y.H.; Zhou, C.Z.; Chen, Y.
Structures of the substrate-binding protein provide insights into the multiple compatible solute binding specificities of the Bacillus subtilis ABC transporter OpuC
Biochem. J.
436
283-289
2011
Bacillus subtilis (O32243), Bacillus subtilis
Gul, N.; Schuurman-Wolters, G.; Karasawa, A.; Poolman, B.
Functional characterization of amphipathic alpha-helix in the osmoregulatory ABC transporter OpuA
Biochemistry
51
5142-5152
2012
Lactococcus lactis
Pittelkow, M.; Tschapek, B.; Smits, S.H.; Schmitt, L.; Bremer, E.
The crystal structure of the substrate-binding protein OpuBC from Bacillus subtilis in complex with choline
J. Mol. Biol.
411
53-67
2011
Bacillus subtilis (Q45462), Bacillus subtilis, Bacillus subtilis JH642 (Q45462)
Pilonieta, M.C.; Nagy, T.A.; Jorgensen, D.R.; Detweiler, C.S.
A glycine betaine importer limits Salmonella stress resistance and tissue colonization by reducing trehalose production
Mol. Microbiol.
84
296-309
2012
Salmonella enterica
Wolters, J.; Ronnie, P.; Gul, N.; Karasawa, A.; Andy-Mark, W.; Slotboom, D.; Poolman, B.
Ligand binding and crystal structures of the substrate-binding domain of the ABC transporter OpuA
PLoS ONE
5
e10361
2010
Lactococcus lactis (Q7DAU8), Lactococcus lactis
Hoffmann, T.; Wensing, A.; Brosius, M.; Steil, L.; Voelker, U.; Bremer, E.
Osmotic control of opuA expression in Bacillus subtilis and its modulation in response to intracellular glycine betaine and proline pools
J. Bacteriol.
195
510-522
2013
Bacillus subtilis, Bacillus subtilis JH642
Karasawa, A.; Swier, L.J.; Stuart, M.C.; Brouwers, J.; Helms, B.; Poolman, B.
Physicochemical factors controlling the activity and energy coupling of an ionic strength-gated ATP-binding cassette (ABC) transporter
J. Biol. Chem.
288
29862-29871
2013
Lactococcus lactis, Lactococcus lactis Opu401
Bashir, A.; Hoffmann, T.; Kempf, B.; Xie, X.; Smits, S.; Bremer, E.
Plant-derived compatible solutes proline betaine and betonicine confer enhanced osmotic and temperature stress tolerance to Bacillus subtilis
Microbiology
160
2283-2294
2014
Bacillus subtilis
Gul, N.; Poolman, B.
Functional reconstitution and osmoregulatory properties of the ProU ABC transporter from Escherichia coli
Mol. Membr. Biol.
30
138-148
2013
Escherichia coli
Teichmann, L.; Kuemmel, H.; Warmbold, B.; Bremer, E.
OpuF a new Bacillus compatible solute ABC transporter with a substrate-binding protein fused to the trans-membrane domain
Appl. Environ. Microbiol.
84
e01728-18
2018
no activity in Bacillus subtilis, Bacillus infantis, Ectobacillus panaciterrae
Ronzheimer, S.; Warmbold, B.; Arnhold, C.; Bremer, E.
The GbsR family of transcriptional regulators functional characterization of the OpuAR repressor
Front. Microbiol.
9
2536
2018
Bacillus subtilis (P46921), Bacillus subtilis (P46922), Bacillus infantis (U5LFB4 AND U5LHK3 AND U5LHN4), Bacillus subtilis 168 (P46921), Bacillus subtilis 168 (P46922), Bacillus infantis NRRL B-14911 (U5LFB4 AND U5LHK3 AND U5LHN4)
Ma, Y.; Wang, Q.; Gao, X.; Zhang, Y.
Biosynthesis and uptake of glycine betaine as cold-stress response to low temperature in fish pathogen Vibrio anguillarum
J. Microbiol.
55
44-55
2017
Vibrio anguillarum serotype O1 (A0A077T980 AND A0A077T7U5 AND A0A077T7Z1), Vibrio anguillarum serotype O1 (A0A097A5F2 AND A0A077T7R8), Vibrio anguillarum serotype O1 MVM425 (A0A077T980 AND A0A077T7U5 AND A0A077T7Z1), Vibrio anguillarum serotype O1 MVM425 (A0A097A5F2 AND A0A077T7R8)
Teichmann, L.; Chen, C.; Hoffmann, T.; Smits, S.H.J.; Schmitt, L.; Bremer, E.
From substrate specificity to promiscuity hybrid ABC transporters for osmoprotectants
Mol. Microbiol.
104
761-780
2017
Bacillus subtilis (P46921), Bacillus subtilis (P46922), Bacillus subtilis, Bacillus subtilis 168 (P46921), Bacillus subtilis 168 (P46922), Bacillus subtilis JH642 (P46921), Bacillus subtilis JH642 (P46922)
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