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Information on EC 7.6.2.9 - ABC-type quaternary amine transporter
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7.6.2.9 ABC-type quaternary amine transporterIUBMB Comments
An ATP-binding cassette (ABC) type transporter, characterized by the presence of two similar ATP-binding domains/proteins and two integral membrane domains/proteins. Does not undergo phosphorylation during the transport process. A bacterial enzyme that interacts with an extracytoplasmic substrate binding protein and mediates the high affinity uptake of quaternary amine derivatives.
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Word Map
- 7.6.2.9
- cassette
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multidrug
- p-glycoprotein
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nucleotide-binding
- toxin
- streptococcus
- lipoprotein
- xenobiotics
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bacteriocins
- azole
- doxorubicin
- verapamil
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siderophore
- cftr
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resistance-associated
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chemoresistance
- lactococcus
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two-component
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hoechst
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cystic
- rhodamine
- elasticum
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atp-bound
- nisin
- mitoxantrone
- molecular biology
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cry1ac
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abc-transporter
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abcb11
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azole-resistant
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calcein
- ivermectin
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proteoliposomes
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atp-driven
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lantibiotic
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abcg2-mediated
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pseudoxanthoma
- flippase
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abccs
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transporter-mediated
- thuringiensis
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triphosphate-binding
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outward-facing
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canalicular
- stargardt
- bacitracin
- adrenoleukodystrophy
- fluconazole
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nucleotide-free
- itraconazole
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inward-facing
The enzyme appears in viruses and cellular organisms
Reaction Schemes
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quaternary amine-[quaternary amine-binding protein][side 1]
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quaternary amine[side 2]
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[quaternary amine-binding protein][side 1]
Synonyms
abc transporter, opuac, glycine betaine-binding protein, opubc, opucc, glycine betaine porter ii, opuab, 
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
Quaternary-amine-transporting ATPase
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
hydrolysis of phosphoric ester
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SYSTEMATIC NAME
IUBMB Comments
ATP phosphohydrolase (ABC-type, quaternary-amine-importing)
An ATP-binding cassette (ABC) type transporter, characterized by the presence of two similar ATP-binding domains/proteins and two integral membrane domains/proteins. Does not undergo phosphorylation during the transport process. A bacterial enzyme that interacts with an extracytoplasmic substrate binding protein and mediates the high affinity uptake of quaternary amine derivatives.
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CAS REGISTRY NUMBER
COMMENTARY
9000-83-3
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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Adenocarcinoma
CD133+ human colorectal adenocarcinoma cells are resistant to staining with fluorescent dyes used for analysis of ABC transporter activities.
Adenocarcinoma of Lung
MDIG promotes cisplatin resistance of lung adenocarcinoma by regulating ABC transporter expression via activation of the WNT/?-catenin signaling pathway.
Adrenocortical Carcinoma
Protection of platinum-DNA adduct formation and reversal of cisplatin resistance by anti-MRP2 hammerhead ribozymes in human cancer cells.
Adrenoleukodystrophy
Characterization and analysis of conserved motifs in a peroxisomal ATP-binding cassette transporter.
Adrenoleukodystrophy
Generation of a WA14 hESC sub-line carrying a hemizygous ABCD1 (C.1696_1710 del) mutation introduced by CRISPR/Cas9 technology.
Adrenoleukodystrophy
Role of ATP-binding cassette transporters in brain lipid transport and neurological disease.
Adrenoleukodystrophy
The NBDs that wouldn't die: A cautionary tale of the use of isolated nucleotide binding domains of ABC transporters.
Adrenoleukodystrophy
Thyroid hormone induction of the adrenoleukodystrophy-related gene (ABCD2).
Alzheimer Disease
Down-regulation of SORL1 is associated with Alzheimer's disease through activating ABC transporter pathway.
Alzheimer Disease
Role of Abca7 in mouse behaviours relevant to neurodegenerative diseases.
Alzheimer Disease
Role of ATP-binding cassette transporters in brain lipid transport and neurological disease.
Amyotrophic Lateral Sclerosis
Excess glutamate secreted from astrocytes drives upregulation of P-glycoprotein in endothelial cells in amyotrophic lateral sclerosis.
Anemia, Hypochromic
A mutation of the mitochondrial ABC transporter Sta1 leads to dwarfism and chlorosis in the Arabidopsis mutant starik.
Anemia, Sideroblastic
Cloning and chromosomal mapping of a novel ABC transporter gene (hABC7), a candidate for X-linked sideroblastic anemia with spinocerebellar ataxia.
Anemia, Sideroblastic
Dimeric ferrochelatase bridges ABCB7 and ABCB10 homodimers in an architecturally defined molecular complex required for heme biosynthesis.
Angioid Streaks
[What can we learn from molecular genetic analyses of inherited eye diseases?]
Arthritis
Lycopene used as Anti-inflammatory Nanodrug for the Treatment of Rheumathoid Arthritis: Animal assay, Pharmacokinetics, ABC Transporter and Tissue Deposition.
Arthritis
The role of the innate immune response regulatory gene ABCF1 in mammalian embryogenesis and development.
Arthritis, Rheumatoid
ABC transporter genes and methotrexate response in rheumatoid arthritis.
Asthma
The impact of cigarette smoke exposure, COPD, or asthma status on ABC transporter gene expression in human airway epithelial cells.
Ataxia
Dimeric ferrochelatase bridges ABCB7 and ABCB10 homodimers in an architecturally defined molecular complex required for heme biosynthesis.
Atherosclerosis
Retinoic acid receptor agonists regulate expression of ATP-binding cassette transporter G1 in macrophages.
Autoimmune Pancreatitis
The role of the innate immune response regulatory gene ABCF1 in mammalian embryogenesis and development.
Bacteremia
Differential gene expression in Streptococcus pneumoniae in response to various iron sources.
Bacterial Infections
Caenorhabditis elegans pgp-5 is involved in resistance to bacterial infection and heavy metal and its regulation requires TIR-1 and a p38 map kinase cascade.
Bacterial Infections
The ybiT gene of Erwinia chrysanthemi codes for a putative ABC transporter and is involved in competitiveness against endophytic bacteria during infection.
Biliary Atresia
Mass spectrometry-based abundance atlas of ABC transporters in human liver, gut, kidney, brain and skin.
Brain Diseases
ATP-binding cassette transporters expression in rats with cirrhosis and hepatic encephalopathy.
Brain Injuries
Deactivation of ATP-Binding Cassette Transporters ABCB1 and ABCC1 Does Not Influence Post-ischemic Neurological Deficits, Secondary Neurodegeneration and Neurogenesis, but Induces Subtle Microglial Morphological Changes.
Breast Neoplasms
A functional single nucleotide polymorphism in ABCC11, rs17822931, is associated with the risk of breast cancer in Japanese.
Breast Neoplasms
ABC drug transporter expression and functional activity in trophoblast-like cell lines and differentiating primary trophoblast.
Breast Neoplasms
ABC transporters do not contribute to extracellular translocation of hyaluronan in human breast cancer in vitro.
Breast Neoplasms
Absorption characteristic of paeoniflorin-6'-O-benzene sulfonate (CP-25) in in situ single-pass intestinal perfusion in rats.
Breast Neoplasms
Association between breast cancer risk and the wild-type allele of human ABC transporter ABCC11.
Breast Neoplasms
Bisphenol A Inhibits the Transporter Function of the Blood-Brain Barrier by Directly Interacting with the ABC Transporter Breast Cancer Resistance Protein (BCRP).
Breast Neoplasms
Blood-Brain Barrier and Breast Cancer Resistance Protein: a limit to the therapy of CNS tumors and neurodegenerative diseases.
Breast Neoplasms
Breast cancer resistance protein impacts clinical outcome in platinum-based chemotherapy for advanced non-small cell lung cancer.
Breast Neoplasms
Characterization of drug transport, ATP hydrolysis, and nucleotide trapping by the human ABCG2 multidrug transporter. Modulation of substrate specificity by a point mutation.
Breast Neoplasms
Co-suppression of MDR1 (multidrug resistance 1) and GCS (glucosylceramide synthase) restores sensitivity to multidrug resistance breast cancer cells by RNA interference (RNAi).
Breast Neoplasms
Design, synthesis and biological evaluation of benzamide and phenyltetrazole derivatives with amide and urea linkers as BCRP inhibitors.
Breast Neoplasms
Dominant-negative inhibition of breast cancer resistance protein as drug efflux pump through the inhibition of S-S dependent homodimerization.
Breast Neoplasms
Earwax, osmidrosis, and breast cancer: why does one SNP (538G>A) in the human ABC transporter ABCC11 gene determine earwax type?
Breast Neoplasms
Elevated survivin mediated multidrug resistance and reduced apoptosis in breast cancer stem cells.
Breast Neoplasms
Enhanced SLC34A2 in breast cancer stem cell-like cells induces chemotherapeutic resistance to doxorubicin via SLC34A2-Bmi1-ABCC5 signaling.
Breast Neoplasms
Expression of breast cancer resistance protein is associated with a poor clinical outcome in patients with small-cell lung cancer.
Breast Neoplasms
Folate deprivation results in the loss of breast cancer resistance protein (BCRP/ABCG2) expression. A role for BCRP in cellular folate homeostasis.
Breast Neoplasms
Friend or foe: ABCG2, ABCC1 and ABCB1 expression in triple-negative breast cancer.
Breast Neoplasms
Functional expression of breast cancer resistance protein and cholesterol effect in human erythrocyte membranes.
Breast Neoplasms
Gene expression profiling of ATP-binding cassette (ABC) transporters as a predictor of the pathologic response to neoadjuvant chemotherapy in breast cancer patients.
Breast Neoplasms
Growth and differentiation of progenitor/stem cells derived from the human mammary gland.
Breast Neoplasms
Guajadial reverses multidrug resistance by inhibiting ABC transporter expression and suppressing the PI3K/Akt pathway in drug-resistant breast cancer cells.
Breast Neoplasms
Hyperforin inhibits P-gp and BCRP activities in chronic lymphocytic leukaemia cells and myeloid cells.
Breast Neoplasms
Imaging of hepatic drug transporters with [131I]6-?-iodomethyl-19-norcholesterol.
Breast Neoplasms
In vitro baselining of new pyrrolopyrimidine EGFR-TK inhibitors with Erlotinib.
Breast Neoplasms
Inhibition of breast cancer resistance protein (ABCG2) in human myeloid dendritic cells induces potent tolerogenic functions during LPS stimulation.
Breast Neoplasms
Insight into structural features of phenyltetrazole derivatives as ABCG2 inhibitors for the treatment of multidrug resistance in cancer.
Breast Neoplasms
Interaction of the breast cancer resistance protein with plant polyphenols.
Breast Neoplasms
Investigation of quinazolines as inhibitors of breast cancer resistance protein (ABCG2).
Breast Neoplasms
Methods to Discover Alternative Promoter Usage and Transcriptional Regulation of Murine Bcrp1.
Breast Neoplasms
Methotrexate cross-resistance in a mitoxantrone-selected multidrug-resistant MCF7 breast cancer cell line is attributable to enhanced energy-dependent drug efflux.
Breast Neoplasms
Modulation of BCRP mediated atypical multidrug resistance phenotype by RNA interference.
Breast Neoplasms
MRP1 modulators synergize with buthionine sulfoximine to exploit collateral sensitivity and selectively kill MRP1-expressing cancer cells.
Breast Neoplasms
MRP8, a new member of ABC transporter superfamily, identified by EST database mining and gene prediction program, is highly expressed in breast cancer.
Breast Neoplasms
MRP9, an unusual truncated member of the ABC transporter superfamily, is highly expressed in breast cancer.
Breast Neoplasms
Novel 3,4-Dihydroisocoumarins Inhibit Human P-gp and BCRP in Multidrug Resistant Tumors and Demonstrate Substrate Inhibition of Yeast Pdr5.
Breast Neoplasms
Pharmacogenetic characterization of sulfasalazine disposition based on NAT2 and ABCG2 (BCRP) gene polymorphisms in humans.
Breast Neoplasms
Pharmacogenomics of human ABC transporter ABCC11 (MRP8): potential risk of breast cancer and chemotherapy failure.
Breast Neoplasms
Regulation of ABC transporters blood-brain barrier: the good, the bad, and the ugly.
Breast Neoplasms
Relationship between intratumoral expression of genes coding for xenobiotic-metabolizing enzymes and benefit from adjuvant tamoxifen in estrogen receptor alpha-positive postmenopausal breast carcinoma.
Breast Neoplasms
Reversal of drug resistance by JS-K and nitric oxide in ABCB1- and ABCG2-expressing multi-drug resistant human tumor cells.
Breast Neoplasms
Reversing multidrug resistance in breast cancer cells by silencing ABC transporter genes with nanoparticle-facilitated delivery of target siRNAs.
Breast Neoplasms
Role of Four ABC Transporter Genes in Pharmacogenetic Susceptibility to Breast Cancer in Jordanian Patients.
Breast Neoplasms
Structure activity relationships and quantitative structure activity relationships for the flavonoid-mediated inhibition of breast cancer resistance protein.
Breast Neoplasms
Structure-activity relationships and quantitative structure-activity relationships for breast cancer resistance protein (ABCG2).
Breast Neoplasms
Synthesis and quantitative structure-activity relationships of selective BCRP inhibitors.
Breast Neoplasms
Tariquidar Is an Inhibitor and Not a Substrate of Human and Mouse P-glycoprotein.
Breast Neoplasms
The beta-carboline alkaloid harmine inhibits BCRP and can reverse resistance to the anticancer drugs mitoxantrone and camptothecin in breast cancer cells.
Breast Neoplasms
The effect of co-administered flavonoids on the metabolism of hesperetin and the disposition of its metabolites in Caco-2 cell monolayers.
Breast Neoplasms
The effects of DMARDs on the expression and function of P-gp, MRPs, BCRP in the treatment of autoimmune diseases.
Breast Neoplasms
The role of UDP-glucuronosyltransferases and drug transporters in breast cancer drug resistance.
Breast Neoplasms
The stem cell marker Bcrp/ABCG2 enhances hypoxic cell survival through interactions with heme.
Breast Neoplasms
Tissue distribution and hormonal regulation of the breast cancer resistance protein (Bcrp/Abcg2) in rats and mice.
Breast Neoplasms
Transport mechanism and affinity of [99mTc]mercaptoacetyltriglycine ([99mTc]MAG3) on the apical membrane of renal proximal tubule cells.
Carcinogenesis
A functional single nucleotide polymorphism in ABCC11, rs17822931, is associated with the risk of breast cancer in Japanese.
Carcinoma
ATP-binding cassette superfamily transporter gene expression in human primary ovarian carcinoma.
Carcinoma
Diagnostic and prognostic value of ABC transporter family member ABCG1 gene in clear cell renal cell carcinoma.
Carcinoma
Enhanced exposure of phosphatidylserine in human gastric carcinoma cells overexpressing the half-size ABC transporter BCRP (ABCG2).
Carcinoma
Expression of ABC transporters is an unfavorable prognostic factor in laryngeal squamous cell carcinoma.
Carcinoma
Plasma membrane calcium ATPase (PMCA4): A housekeeper for RT-PCR relative quantification of polytopic membrane proteins.
Carcinoma
Protection of platinum-DNA adduct formation and reversal of cisplatin resistance by anti-MRP2 hammerhead ribozymes in human cancer cells.
Carcinoma
Reversal of different drug-resistant phenotypes by an autocatalytic multitarget multiribozyme directed against the transcripts of the ABC transporters MDR1/P-gp, MRP2, and BCRP.
Carcinoma, Hepatocellular
Comparative analysis of ATP-binding cassette (ABC) transporter gene expression levels in peripheral blood leukocytes and in liver with hepatocellular carcinoma.
Carcinoma, Hepatocellular
Comparison of cytotoxicity and membrane efflux pump inhibition in HepG2 cells induced by single-walled carbon nanotubes with different length and functional groups.
Carcinoma, Hepatocellular
Nrf2 signaling promotes cancer stemness, migration, and expression of ABC transporter genes in sorafenib-resistant hepatocellular carcinoma cells.
Carcinoma, Hepatocellular
Systematic analysis of the ABC transporter family in hepatocellular carcinoma reveals the importance of ABCB6 in regulating ferroptosis.
Carcinoma, Renal Cell
Diagnostic and prognostic value of ABC transporter family member ABCG1 gene in clear cell renal cell carcinoma.
Celiac Disease
Associations between alleles of the major histocompatibility complex-encoded ABC transporter gene TAP2, HLA class II alleles, and celiac disease susceptibility.
Central Nervous System Diseases
Blood-Brain Barrier and Breast Cancer Resistance Protein: a limit to the therapy of CNS tumors and neurodegenerative diseases.
Chemical and Drug Induced Liver Injury
Selected ABCB1, ABCB4 and ABCC2 polymorphisms do not enhance the risk of drug-induced hepatotoxicity in a Spanish cohort.
Cholelithiasis
Genetics of gallstone disease revisited: updated inventory of human lithogenic genes.
Cholelithiasis
[Recurrent intrahepatic cholestasis of pregnancy and chain-like choledocholithiasis in a female patient with stop codon in the ABDC4-gene of the hepatobiliary phospholipid transporter]
Cholestasis
Hydrophilic bile salts have a cytoprotective effect against cyclosporine A-induced cholestasis through enhanced canalicular membrane fluidity and transporter activity.
Cholestasis
Intracellular trafficking and regulation of canalicular ATP-binding cassette transporters.
Cholestasis
MDR3 (ABCB4) defects: a paradigm for the genetics of adult cholestatic syndromes.
Cholestasis
Role of farnesoid X receptor in determining hepatic ABC transporter expression and liver injury in bile duct-ligated mice.
Cholestasis, Intrahepatic
A gene encoding a liver-specific ABC transporter is mutated in progressive familial intrahepatic cholestasis.
Cholestasis, Intrahepatic
Molecular Mechanism of Taurocholate Transport by the Bile Salt Export Pump, an ABC Transporter Associated with Intrahepatic Cholestasis.
Cholestasis, Intrahepatic
Whole-exome sequencing identifies novel mutations in ABC transporter genes associated with intrahepatic cholestasis of pregnancy disease: a case-control study.
Chorioamnionitis
Chorioamnionitis Induces a Specific Signature of Placental ABC Transporters Associated with an Increase of miR-331-5p in the Human Preterm Placenta.
Choriocarcinoma
ABCG2/BCRP decreases the transfer of a food-born chemical carcinogen, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in perfused term human placenta.
Choriocarcinoma
Induction of cells differentiation and ABC transporters expression by a myco-estrogen, zearalenone, in human choriocarcinoma cell line (BeWo).
Choroidal Neovascularization
[What can we learn from molecular genetic analyses of inherited eye diseases?]
Colitis, Ulcerative
Profiling of ABC Transporters During Active Ulcerative Colitis and In Vitro Effect of Inflammatory Modulators.
Colonic Neoplasms
Can curcumin along with chemotherapeutic drug and lipid provide an effective treatment of metastatic colon cancer and alter multidrug resistance?
Colonic Neoplasms
Depletion of Lipid Efflux Pump ABCG1 Triggers the Intracellular Accumulation of Extracellular Vesicles and Reduces Aggregation and Tumorigenesis of Metastatic Cancer Cells.
Colonic Neoplasms
Lamellarins as inhibitors of P-glycoprotein-mediated multidrug resistance in a human colon cancer cell line.
Colonic Neoplasms
Oxidative Stress Promotes Doxorubicin-Induced Pgp and BCRP Expression in Colon Cancer Cells Under Hypoxic Conditions.
Colorectal Neoplasms
ABCB1 and ABCG2 restricts the efficacy of gedatolisib (PF-05212384), a PI3K inhibitor in colorectal cancer cells.
Colorectal Neoplasms
Association of ABC Transporter With Resistance to FK866, a NAMPT Inhibitor, in Human Colorectal Cancer Cells.
Colorectal Neoplasms
HES1 Promotes Colorectal Cancer Cell Resistance To 5-Fu by Inducing Of EMT and ABC Transporter Proteins.
Colorectal Neoplasms
Oligomeric proanthocyanidins (OPCs) from grape seed extract suppress the activity of ABC transporters in overcoming chemoresistance in colorectal cancer cells.
Colorectal Neoplasms
P-Glycoprotein 1 Affects Chemoactivities of Resveratrol against Human Colorectal Cancer Cells.
Colorectal Neoplasms
Polymorphisms in ATP-binding cassette transporter genes and interaction with diet and life style factors in relation to colorectal cancer in a Danish prospective case-cohort study.
Coma
12-Oxo-Phytodienoic Acid Accumulation during Seed Development Represses Seed Germination in Arabidopsis.
Coma
Combinatorial Effects of Aromatic 1,3-Disubstituted Ureas and Fluoride on In vitro Inhibition of Streptococcus mutans Biofilm Formation.
Coma
Intrinsic acyl-CoA thioesterase activity of a peroxisomal ATP binding cassette transporter is required for transport and metabolism of fatty acids.
Coma
Pseudo half-molecules of the ABC transporter, COMATOSE, bind Pex19 and target to peroxisomes independently but are both required for activity.
Coma
Substrate recognition mechanism of the peptidase domain of the quorum-sensing-signal-producing ABC transporter ComA from Streptococcus.
Coma
The Arabidopsis peroxisomal ABC transporter, comatose, complements the Saccharomyces cerevisiae pxa1 pxa2Delta mutant for metabolism of long-chain fatty acids and exhibits fatty acyl-CoA-stimulated ATPase activity.
Coma
The NBDs that wouldn't die: A cautionary tale of the use of isolated nucleotide binding domains of ABC transporters.
Communicable Diseases
Availability and applications of ATP-binding cassette (ABC) transporter blockers.
Cone-Rod Dystrophies
Biochemical defects in retina-specific human ATP binding cassette transporter nucleotide binding domain 1 mutants associated with macular degeneration.
Cone-Rod Dystrophies
De novo deletion removes a conserved motif in the C-terminus of ABCA4 and results in cone-rod dystrophy.
Cone-Rod Dystrophies
Interaction of extracellular domain 2 of the human retina-specific ABC transporter (ABCA4) with all-trans retinal.
Crohn Disease
Integrating genetic and gene expression evidence into genome-wide association analysis of gene sets.
Cystic Fibrosis
A stable ATP binding to the nucleotide binding domain is important for reliable gating cycle in an ABC transporter CFTR.
Cystic Fibrosis
ADP inhibits function of the ABC transporter cystic fibrosis transmembrane conductance regulator via its adenylate kinase activity.
Cystic Fibrosis
An energy-dependent maturation step is required for release of the cystic fibrosis transmembrane conductance regulator from early endoplasmic reticulum biosynthetic machinery.
Cystic Fibrosis
Building an understanding of cystic fibrosis on the foundation of ABC transporter structures.
Cystic Fibrosis
Co-ordinate regulation of the cystic fibrosis and multidrug resistance genes in cystic fibrosis knockout mice.
Cystic Fibrosis
Co-Translational Folding of the First Transmembrane Domain of ABC-Transporter CFTR is Supported by Assembly with the First Cytosolic Domain.
Cystic Fibrosis
Cystic fibrosis transmembrane conductance regulator (CFTR) functionality is dependent on coatomer protein I (COPI).
Cystic Fibrosis
Cystic Fibrosis Transmembrane Conductance Regulator: A Molecular Model Defines the Architecture of the Anion Conduction Path and Locates a "Bottleneck" in the Pore.
Cystic Fibrosis
Domain interactions in the yeast ATP binding cassette transporter Ycf1p: intragenic suppressor analysis of mutations in the nucleotide binding domains.
Cystic Fibrosis
Effect of cystic fibrosis-associated mutations in the fourth intracellular loop of cystic fibrosis transmembrane conductance regulator.
Cystic Fibrosis
Ethnogeographic and inter-individual variability of human ABC transporters.
Cystic Fibrosis
Gout-causing Q141K mutation in ABCG2 leads to instability of the nucleotide-binding domain and can be corrected with small molecules.
Cystic Fibrosis
Identification of molecular determinants that modulate trafficking of DeltaF508 CFTR, the mutant ABC transporter associated with cystic fibrosis.
Cystic Fibrosis
Interactions between ABCC4/MRP4 and ABCC7/CFTR in human airway epithelial cells in lung health and disease.
Cystic Fibrosis
Modeling of nucleotide binding domains of ABC transporter proteins based on a F1-ATPase/recA topology: structural model of the nucleotide binding domains of the cystic fibrosis transmembrane conductance regulator (CFTR).
Cystic Fibrosis
MRP class of human ATP binding cassette (ABC) transporters: historical background and new research directions.
Cystic Fibrosis
New Model of Cystic Fibrosis Transmembrane Conductance Regulator Proposes Active Channel-like Conformation.
Cystic Fibrosis
Nucleotide-binding Domains of Cystic Fibrosis Transmembrane Conductance Regulator, an ABC Transporter, Catalyze Adenylate Kinase Activity but Not ATP Hydrolysis.
Cystic Fibrosis
Origin and evolution of the cystic fibrosis transmembrane regulator protein R domain.
Cystic Fibrosis
Rescuing Trafficking Mutants of the ATP-binding Cassette Protein, ABCA4, with Small Molecule Correctors as a Treatment for Stargardt Eye Disease.
Cystic Fibrosis
Sequence analysis of the CEN12 region of Saccharomyces cerevisiae on a 43.7 kb fragment of chromosome XII including an open reading frame homologous to the human cystic fibrosis transmembrane conductance regulator protein CFTR.
Cystic Fibrosis
State-dependent inhibition of cystic fibrosis transmembrane conductance regulator chloride channels by a novel peptide toxin.
Cystic Fibrosis
Strategies for cystic fibrosis transmembrane conductance regulator inhibition: from molecular mechanisms to treatment for secretory diarrhoeas.
Cystic Fibrosis
Structural analogues of roscovitine rescue the intracellular traffic and the function of ER-retained ABCB4 variants in cell models.
Cystic Fibrosis
Structural stability of purified human CFTR is systematically improved by mutations in nucleotide binding domain 1.
Cystic Fibrosis
The deubiquitinating enzyme USP10 regulates the post-endocytic sorting of CFTR in airway epithelial cells.
Cystic Fibrosis
The role of cystic fibrosis transmembrane conductance regulator phenylalanine 508 side chain in ion channel gating.
Dehydration
EMS Derived Wheat Mutant BIG8-1 (Triticum aestivum L.)-A New Drought Tolerant Mutant Wheat Line.
Dehydration
Osmoregulated ABC-transport system of Lactococcus lactis senses water stress via changes in the physical state of the membrane.
Demyelinating Diseases
Thyroid hormone induction of the adrenoleukodystrophy-related gene (ABCD2).
Dermatitis, Phototoxic
Cellular Phototoxicity Evoked Through the Inhibition of Human ABC Transporter ABCG2 by Cyclin-dependent Kinase Inhibitors In vitro.
Dermatitis, Phototoxic
Drug-induced phototoxicity evoked by inhibition of human ABC transporter ABCG2: development of in vitro high-speed screening systems.
Diabetes Mellitus
Berberine Improves the Symptoms of DHEA-Induced PCOS Rats by Regulating Gut Microbiotas and Metabolites.
Diabetes Mellitus, Type 2
ABC transporter genes and risk of type 2 diabetes: a study of 40,000 individuals from the general population.
Diabetes Mellitus, Type 2
Berberine Improves the Symptoms of DHEA-Induced PCOS Rats by Regulating Gut Microbiotas and Metabolites.
Diabetes, Gestational
Placental ABC transporters, cellular toxicity and stress in pregnancy.
Diffuse Intrinsic Pontine Glioma
ABC Transporter Inhibition Plus Dexamethasone Enhances the Efficacy of Convection Enhanced Delivery in H3.3K27M Mutant Diffuse Intrinsic Pontine Glioma.
Drug Resistant Epilepsy
Computer-Aided Recognition of ABC Transporters Substrates and Its Application to the Development of New Drugs for Refractory Epilepsy.
Drug Resistant Epilepsy
Research Progress on the Role of ABC Transporters in the Drug Resistance Mechanism of Intractable Epilepsy.
Drug-Related Side Effects and Adverse Reactions
Vacuolar sequestration of azoles: A novel strategy of azole antifungal resistance conserved across pathogenic and non-pathogenic yeast.
Dwarfism
A mutation of the mitochondrial ABC transporter Sta1 leads to dwarfism and chlorosis in the Arabidopsis mutant starik.
Endocarditis
AhrC and Eep Are Biofilm Infection-Associated Virulence Factors in Enterococcus faecalis.
Epilepsy
Exploring the possible interaction between anti-epilepsy drugs and multidrug efflux pumps; in vitro observations.
Epilepsy
PET and SPECT Radiotracers to Assess Function and Expression of ABC Transporters in Vivo.
Epilepsy
PET tracers for imaging of ABC transporters at the blood-brain barrier: Principles and Strategies.
Fetal Growth Retardation
The ABC transporter BCRP/ABCG2 is a placental survival factor, and its expression is reduced in idiopathic human fetal growth restriction.
Gallbladder Neoplasms
Genetics of gallstone disease revisited: updated inventory of human lithogenic genes.
Gallstones
Genetics of gallstone disease revisited: updated inventory of human lithogenic genes.
Genetic Diseases, Inborn
Discovery of regulatory elements in human ATP-binding cassette transporters through expression quantitative trait mapping.
Genetic Diseases, Inborn
Large-scaled metabolic profiling of human dermal fibroblasts derived from pseudoxanthoma elasticum patients and healthy controls.
Glioblastoma
Integrating genetic and gene expression evidence into genome-wide association analysis of gene sets.
Glioblastoma
Integration of gene expression and methylation to unravel biological networks in glioblastoma patients.
Glioblastoma
Targeting the ABC transporter ABCB5 sensitizes glioblastoma to temozolomide-induced apoptosis through a cell-cycle checkpoint regulation mechanism.
Glioma
ABC Transporter Inhibition Plus Dexamethasone Enhances the Efficacy of Convection Enhanced Delivery in H3.3K27M Mutant Diffuse Intrinsic Pontine Glioma.
Glioma
Doxorubicin loaded iron oxide nanoparticles overcome multidrug resistance in cancer in vitro.
Glioma
Inhibition of multidrug resistance protein 1 (MRP1) improves chemotherapy drug response in primary and recurrent glioblastoma multiforme.
Glioma
Integration of gene expression and methylation to unravel biological networks in glioblastoma patients.
Glioma
PTEN/PI3K/Akt pathway regulates the side population phenotype and ABCG2 activity in glioma tumor stem-like cells.
Glioma
Requirement of ABC transporter inhibition and Hoechst 33342 dye deprivation for the assessment of side population-defined C6 glioma stem cell metabolism using fluorescent probes.
Gout
Metabolic Interactions of Purine Derivatives with Human ABC Transporter ABCG2: Genetic Testing to Assess Gout Risk.
Gout
The structure of the human ABC transporter ABCG2 reveals a novel mechanism for drug extrusion.
Hepatitis
Decreased expression of an ATP-binding cassette transporter, MRP2, in human livers with hepatitis C virus infection.
Hepatitis
[Recurrent intrahepatic cholestasis of pregnancy and chain-like choledocholithiasis in a female patient with stop codon in the ABDC4-gene of the hepatobiliary phospholipid transporter]
Hypersensitivity
Aluminum-dependent root-growth inhibition in Arabidopsis results from AtATR-regulated cell-cycle arrest.
Hypersensitivity
Loss of an ABC transporter in Arabidopsis thaliana confers hypersensitivity to the anti-cancer drug bleomycin.
Infections
ABC transporter and metallothionein expression affected by NI and Epichloe endophyte infection in tall fescue.
Infections
AhrC and Eep Are Biofilm Infection-Associated Virulence Factors in Enterococcus faecalis.
Infections
ATP-Binding Cassette (ABC) Transporters of the Human Respiratory Tract Pathogen, Moraxella catarrhalis: Role in Virulence.
Infections
Aurantimycin resistance genes contribute to survival of Listeria monocytogenes during life in the environment.
Infections
BacA, an ABC transporter involved in maintenance of chronic murine infections with Mycobacterium tuberculosis.
Infections
Brucella ovis mutant in ABC transporter protects against Brucella canis infection in mice and it is safe for dogs.
Infections
Burkholderia pseudomallei kills Caenorhabditis elegans through virulence mechanisms distinct from intestinal lumen colonization.
Infections
Characterization and protective activity of monoclonal antibodies directed against Fe (3+) ABC transporter substrate-binding protein of Glaesserella parasuis.
Infections
Deciphering the intracellular metabolism of Listeria monocytogenes by mutant screening and modelling.
Infections
Effects of Deletion of the Streptococcus pneumoniae Lipoprotein Diacylglyceryl Transferase Gene lgt on ABC Transporter Function and on Growth In Vivo.
Infections
Genome-wide identification of Streptococcus pneumoniae genes essential for bacterial replication during experimental meningitis.
Infections
Host-specific functional compartmentalization within the oligopeptide transporter during the Borrelia burgdorferi enzootic cycle.
Infections
Identification of ABC transporters in vancomycin-resistant Enterococcus faecium as potential targets for antibody therapy.
Infections
Identification of an immunodominant ABC transporter in methicillin-resistant Staphylococcus aureus infections.
Infections
Identification of in vivo essential genes from Pseudomonas aeruginosa by PCR-based signature-tagged mutagenesis.
Infections
Immunization with the basic membrane protein (BMP) family ABC transporter elicits protection against Enterococcus faecium in a murine infection model.
Infections
Immunization with the iron uptake ABC transporter proteins PiaA and PiuA prevents respiratory infection with Streptococcus pneumoniae.
Infections
Loss of AtPDR8, a plasma membrane ABC transporter of Arabidopsis thaliana, causes hypersensitive cell death upon pathogen infection.
Infections
MDR1 genetic polymorphism does not modify either cell permissiveness to HIV-1 or disease progression before treatment.
Infections
Pulmonary Surfactant Promotes Virulence Gene Expression and Biofilm Formation in Klebsiella pneumoniae.
Infections
Role of a Fusarium culmorum ABC transporter (FcABC1) during infection of wheat and barley.
Infections
Sulfate-Binding Protein (Sbp) from Xanthomonas citri: Structure and Functional Insights.
Infections
The ABC transporter protein OppA provides protection against experimental Yersinia pestis infection.
Infections
The abcEDCBA-Encoded ABC Transporter and the virB Operon-Encoded Type IV Secretion System of Brucella ovis Are Critical for Intracellular Trafficking and Survival in Ovine Monocyte-Derived Macrophages.
Infections
The CydDC Family of Transporters and Their Roles in Oxidase Assembly and Homeostasis.
Infections
The expression of a putative exotoxin and an ABC transporter during bovine intramammary infection contributes to the virulence of Staphylococcus aureus.
Infections
The inducible amphisome isolates viral hemagglutinin and defends against influenza A virus infection.
Infections
The putative amino acid ABC transporter substrate-binding protein AapJ2 is necessary for Brucella virulence at the early stage of infection in a mouse model.
Infections
The wheat Lr34 multi-pathogen resistance gene confers resistance to anthracnose and rust in sorghum.
Infections
The ybiT gene of Erwinia chrysanthemi codes for a putative ABC transporter and is involved in competitiveness against endophytic bacteria during infection.
Infections
Validation of a novel Mho microarray for a comprehensive characterisation of the Mycoplasma hominis action in HeLa cell infection.
Insulin Resistance
Attenuation of high sucrose diet-induced insulin resistance in ABC transporter deficient white mutant of Drosophila melanogaster.
Intestinal Volvulus
Characterization of a half-size ATP-binding cassette transporter gene which may be a useful marker for ivermectin selection in Onchocerca volvulus.
Intestinal Volvulus
P-glycoprotein-like protein, a possible genetic marker for ivermectin resistance selection in Onchocerca volvulus.
Intestinal Volvulus
Reduced genetic variation of an Onchocerca volvulus ABC transporter gene following treatment with ivermectin.
Iron Deficiencies
Comparative transcriptome analysis reveals gene network regulating cadmium uptake and translocation in peanut roots under iron deficiency.
Iron Deficiencies
New insights into the function of the proteins IsiC and IsiD from Synechocystis sp. PCC 6803 under iron limitation.
Iron Deficiencies
The Nicotiana tabacum ABC transporter NtPDR3 secretes O-methylated coumarins in response to iron deficiency.
Ischemic Stroke
Deactivation of ATP-Binding Cassette Transporters ABCB1 and ABCC1 Does Not Influence Post-ischemic Neurological Deficits, Secondary Neurodegeneration and Neurogenesis, but Induces Subtle Microglial Morphological Changes.
Kidney Neoplasms
Expression of multidrug resistance markers ABCB1 (MDR-1/P-gp) and ABCC1 (MRP-1) in renal cell carcinoma.
Leishmaniasis
Alkyl-lysophospholipid resistance in multidrug-resistant Leishmania tropica and chemosensitization by a novel P-glycoprotein-like transporter modulator.
Leishmaniasis
Glibenclamide modulates glucantime activity and disposition in Leishmania major.
Leishmaniasis
Structure based investigation on the binding interaction of transport proteins in leishmaniasis: insights from molecular simulation.
Leukemia
ARA, a novel ABC transporter, is located at 16p13.1, is deleted in inv(16) leukemias, and is shown to be expressed in primitive hematopoietic precursors.
Leukemia
Intracellular ABC transporter A3 confers multidrug resistance in leukemia cells by lysosomal drug sequestration.
Leukemia
Mesenchymal stromal cells confer chemoresistance to myeloid leukemia blasts through Side Population functionality and ABC transporter activation.
Leukemia
Nilotinib enhances the efficacy of conventional chemotherapeutic drugs in CD34?CD38? stem cells and ABC transporter overexpressing leukemia cells.
Leukemia, Lymphocytic, Chronic, B-Cell
Expression of multidrug resistance-associated ABC transporters in B-CLL is independent of ZAP70 status.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
ABC transporter A3 facilitates lysosomal sequestration of imatinib and modulates susceptibility of chronic myeloid leukemia cell lines to this drug.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Midgut transcriptomal response of the rice leaffolder, Cnaphalocrocis medinalis (Guenée) to Cry1C toxin.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Variation of MDR proteins expression and activity levels according to clinical status and evolution of CML patients.
Leukemia, Myeloid
Mesenchymal stromal cells confer chemoresistance to myeloid leukemia blasts through Side Population functionality and ABC transporter activation.
Leukemia, Myeloid, Acute
ABC transporter ABCA3 is expressed in acute myeloid leukemia blast cells and participates in vesicular transport.
Leukemia, Myeloid, Acute
Histone deacetylase inhibitors induce a very broad, pleiotropic anticancer drug resistance phenotype in acute myeloid leukemia cells by modulation of multiple ABC transporter genes.
Leukemia, Myeloid, Acute
Identification of prognostic subgroups among acute myeloid leukemia patients with intermediate risk cytogenetics using a flow-cytometry-based assessment of ABC-transporter function.
Leukemia, Myeloid, Acute
Intracellular ABC transporter A3 confers multidrug resistance in leukemia cells by lysosomal drug sequestration.
Leukemia, Myeloid, Acute
Prognostic impact of high ABC transporter activity in 111 adult acute myeloid leukemia patients with normal cytogenetics when compared to FLT3, NPM1, CEBPA and BAALC.
Leukemia, T-Cell
Modulation of P-glycoprotein-Mediated Anticancer Drug Accumulation, Cytotoxicity, and ATPase Activity by Flavonoid Interactions.
Liver Diseases
Genetics of gallstone disease revisited: updated inventory of human lithogenic genes.
Liver Neoplasms
Codelivery of doxorubicin and elacridar to target both liver cancer cells and stem cells by polylactide-co-glycolide/d-alpha-tocopherol polyethylene glycol 1000 succinate nanoparticles.
Lung Neoplasms
Expression of breast cancer resistance protein is associated with a poor clinical outcome in patients with small-cell lung cancer.
Lung Neoplasms
Longitudinal time-dependent effects of irradiation on multidrug resistance in a non-small lung cancer cell line.
Lung Neoplasms
[The expression of ABCG4, V-ATPase and clinic significance of their correlation with NSCLC.]
Lymphoma
A longitudinal study of ABC transporter expression in canine multicentric lymphoma.
Lymphoma
Evaluation of cucurbitane-type triterpenoids from Momordica balsamina on P-glycoprotein (ABCB1) by flow cytometry and real-time fluorometry.
Lymphoma, T-Cell
A longitudinal study of ABC transporter expression in canine multicentric lymphoma.
Lymphoproliferative Disorders
Multidrug resistance in the chronic lymphoproliferative disorders.
Macular Degeneration
Biochemical defects in retina-specific human ATP binding cassette transporter nucleotide binding domain 1 mutants associated with macular degeneration.
Macular Degeneration
De novo deletion removes a conserved motif in the C-terminus of ABCA4 and results in cone-rod dystrophy.
Macular Degeneration
Denaturing HPLC profiling of the ABCA4 gene for reliable detection of allelic variations.
Macular Degeneration
Retinal stimulates ATP hydrolysis by purified and reconstituted ABCR, the photoreceptor-specific ATP-binding cassette transporter responsible for Stargardt disease.
Macular Degeneration
Study of FTMT and ABCA4 genes in a patient affected by age-related macular degeneration: identification and analysis of new mutations.
Macular Degeneration
The effect of lipid environment and retinoids on the ATPase activity of ABCR, the photoreceptor ABC transporter responsible for Stargardt macular dystrophy.
Malaria
A female gametocyte-specific ABC transporter plays a role in lipid metabolism in the malaria parasite.
Malaria
Gene expression modulation of ABC transporter genes in response to permethrin in adults of the mosquito malaria vector Anopheles stephensi.
Malaria
Multidrug ATP-binding cassette transporters are essential for hepatic development of Plasmodium sporozoites.
Malaria
Temporal dynamics of the ABC transporter response to insecticide treatment: insights from the malaria vector Anopheles stephensi.
Medulloblastoma
ABC transporter activity linked to radiation resistance and molecular subtype in pediatric medulloblastoma.
Medulloblastoma
An ABC transporter drives medulloblastoma pathogenesis by regulating Sonic Hedgehog signaling.
Melanoma
AC-93253 triggers the downregulation of melanoma progression markers and the inhibition of melanoma cell proliferation.
Melanoma
Inhibitor of vasculogenic mimicry restores sensitivity of resistant melanoma cells to DNA-damaging agents.
Melanoma
Principal expression of two mRNA isoforms (ABCB 5alpha and ABCB 5beta ) of the ATP-binding cassette transporter gene ABCB 5 in melanoma cells and melanocytes.
Melanoma
Protection of platinum-DNA adduct formation and reversal of cisplatin resistance by anti-MRP2 hammerhead ribozymes in human cancer cells.
Melioidosis
CD4+ T-cell immunity to the Burkholderia pseudomallei ABC transporter LolC in melioidosis.
Melioidosis
Phenotypic and Functional Characterization of Human Memory T Cell Responses to Burkholderia pseudomallei.
Meningitis, Bacterial
Computational approaches to identify common subunit vaccine candidates against bacterial meningitis.
Meningitis, Pneumococcal
Genome-wide identification of Streptococcus pneumoniae genes essential for bacterial replication during experimental meningitis.
Mucolipidoses
Suppression of the cup-5 mucolipidosis type IV-related lysosomal dysfunction by the inactivation of an ABC transporter in C. elegans.
Multiple Myeloma
A 13 mer LNA-i-miR-221 Inhibitor Restores Drug Sensitivity in Melphalan-Refractory Multiple Myeloma Cells.
Multiple Myeloma
MicroRNA-451 regulates stemness of side population cells via PI3K/Akt/mTOR signaling pathway in multiple myeloma.
Neoplasm Metastasis
Integrative analysis of two cell lines derived from a non-small-lung cancer patient--a panomics approach.
Neoplasm Metastasis
The role of microRNA in metastatic colorectal cancer and its significance in cancer prognosis and treatment.
Neoplasm Metastasis
Transcriptomic Characterization, Chemosensitivity and Regulatory Effects of Exosomes in Spontaneous EMT/MET Transitions of Breast Cancer Cells.
Neoplasms
(1)H, (13)C, (15)N backbone and side-chain resonance assignments of the human adenylate kinase 1 in apo form.
Neoplasms
2,4,6-Substituted Quinazolines with Extraordinary Inhibitory Potency toward ABCG2.
Neoplasms
2-Trifluoromethyl-2-Hydroxypropionamide Derivatives as Novel Reversal Agents of ABCG2 (BCRP)-Mediated Multidrug Resistance: Synthesis and Biological Evaluations.
Neoplasms
3?-Acetyl tormentic acid reverts MRP1/ABCC1 mediated cancer resistance through modulation of intracellular levels of GSH and inhibition of GST activity.
Neoplasms
A bacterial antibiotic-resistance gene that complements the human multidrug-resistance P-glycoprotein gene.
Neoplasms
A self-assembled pH/enzyme dual-responsive prodrug with PEG deshielding for multidrug-resistant tumor therapy.
Neoplasms
A single active catalytic site is sufficient to promote transport in P-glycoprotein.
Neoplasms
A-803467, a tetrodotoxin-resistant sodium channel blocker, modulates ABCG2-mediated MDR in vitro and in vivo.
Neoplasms
ABC Transporter Inhibition Plus Dexamethasone Enhances the Efficacy of Convection Enhanced Delivery in H3.3K27M Mutant Diffuse Intrinsic Pontine Glioma.
Neoplasms
ABC transporter superfamily. An updated overview, relevance in cancer multidrug resistance and perspectives with personalized medicine.
Neoplasms
ABC transporters, cytochromes P450 and their main transcription factors: expression at the human blood-brain barrier.
Neoplasms
ABCB1 is predominantly expressed in human fetal neural stem/progenitor cells at an early development stage.
Neoplasms
ABCG2 impairs the activity of the aurora kinase inhibitor tozasertib but not of alisertib.
Neoplasms
ABCG2 inhibition as a therapeutic approach for overcoming multidrug resistance in cancer.
Neoplasms
Adenosine triphosphate-dependent transport of estradiol-17beta(beta-D-glucuronide) in membrane vesicles by MDR1 expressed in insect cells.
Neoplasms
Altered expression of the genes regulating apoptosis in multidrug resistant human myeloid leukemia cell lines overexpressing MDR1 or MRP gene.
Neoplasms
Analysis of expression of drug resistance-linked ABC transporters in cancer cells by quantitative RT-PCR.
Neoplasms
Assessing the Stabilization of P-Glycoprotein's Nucleotide-Binding Domains by the Linker, Using Molecular Dynamics.
Neoplasms
ATP-binding cassette superfamily transporter gene expression in human primary ovarian carcinoma.
Neoplasms
ATP-binding cassette transporters in tumor endothelial cells and resistance to metronomic chemotherapy.
Neoplasms
Breast cancer resistance protein impacts clinical outcome in platinum-based chemotherapy for advanced non-small cell lung cancer.
Neoplasms
CD44-positive cells are responsible for gemcitabine resistance in pancreatic cancer cells.
Neoplasms
Characterization of berberine transport into Coptis japonica cells and the involvement of ABC protein.
Neoplasms
Characterization of drug transport, ATP hydrolysis, and nucleotide trapping by the human ABCG2 multidrug transporter. Modulation of substrate specificity by a point mutation.
Neoplasms
Characterization of the ATP-binding cassette transporter gene expression profile in Y79: a retinoblastoma cell line.
Neoplasms
Clinico-pathologic function of cerebral ABC transporters - implications for the pathogenesis of Alzheimer's disease.
Neoplasms
Co-detection of ALDH1A1, ABCG2, ALCAM and CD133 in three A549 subpopulations at the single cell level by one-step digital RT-PCR.
Neoplasms
Codelivery of doxorubicin and elacridar to target both liver cancer cells and stem cells by polylactide-co-glycolide/d-alpha-tocopherol polyethylene glycol 1000 succinate nanoparticles.
Neoplasms
Comparison between tumors in plants and human beings: Mechanisms of tumor development and therapy with secondary plant metabolites.
Neoplasms
Construction of a model cell line for the assay of MDR1 (multi drug resistance gene-1) substrates/inhibitors using HeLa cells.
Neoplasms
Cyclooxygenase-2: potential role in regulation of drug efflux and multidrug resistance phenotype.
Neoplasms
Dacomitinib potentiates the efficacy of conventional chemotherapeutic agents via inhibiting the drug efflux function of ABCG2 in vitro and in vivo.
Neoplasms
Decreased expression of an ATP-binding cassette transporter, MRP2, in human livers with hepatitis C virus infection.
Neoplasms
Development of a cyclin-dependent kinase inhibitor devoid of ABC transporter-dependent drug resistance.
Neoplasms
Direct and coordinate regulation of ATP-binding cassette (ABC) transporter genes by MYC factors generates specific transcription signatures which significantly affect the chemoresistance phenotype of cancer cells.
Neoplasms
Double impact on P-glycoprotein by statins enhances doxorubicin cytotoxicity in human neuroblastoma cells.
Neoplasms
Downregulation of BCRP and anti-apoptotic proteins by proadifen (SKF-525A) is responsible for the enhanced mitoxantrone accumulation and toxicity in mitoxantrone-resistant human promyelocytic leukemia cells.
Neoplasms
Dynamic quantitative detection of ABC transporter family promoter methylation by MS-HRM for predicting MDR in pancreatic cancer.
Neoplasms
Effect of ABC transporter expression and mutational status on survival rates of cancer patients.
Neoplasms
Elevated survivin mediated multidrug resistance and reduced apoptosis in breast cancer stem cells.
Neoplasms
Exome Sequencing of ABCB5 Identifies Recurrent Melanoma Mutations that Result in Increased Proliferative and Invasive Capacities.
Neoplasms
Expression of breast cancer resistance protein is associated with a poor clinical outcome in patients with small-cell lung cancer.
Neoplasms
Expression of multidrug resistance markers ABCB1 (MDR-1/P-gp) and ABCC1 (MRP-1) in renal cell carcinoma.
Neoplasms
FK506 confers chemosensitivity to anticancer drugs in glioblastoma multiforme cells by decreasing the expression of the multiple resistance-associated protein-1.
Neoplasms
Gene expression profiling of ATP-binding cassette (ABC) transporters as a predictor of the pathologic response to neoadjuvant chemotherapy in breast cancer patients.
Neoplasms
Generation and Characterization of an Abcc1 Humanized Mouse Model (hABCC1flx/flx ) with Knockout Capability.
Neoplasms
Glycolysis inhibition inactivates ABC transporters to restore drug sensitivity in malignant cells.
Neoplasms
Harnessing drug resistance: using ABC transporter proteins to target cancer cells.
Neoplasms
Human ABC transporter ABCG2 in cancer chemotherapy: drug molecular design to circumvent multidrug resistance.
Neoplasms
Human ABC transporter ABCG2/BCRP expression in chemoresistance: basic and clinical perspectives for molecular cancer therapeutics.
Neoplasms
Identification and characterisation of putative drug binding sites in human ATP-binding cassette B5 (ABCB5) transporter.
Neoplasms
Identification of ABC Transporter Interaction of a Novel Cyanoquinoline Radiotracer and Implications for Tumour Imaging by Positron Emission Tomography.
Neoplasms
Identification of Xanthones as Selective Killers of Cancer Cells Overexpressing the ABC Transporter MRP1.
Neoplasms
Immunohistochemical expression of BCRP and ERCC1 in biopsy specimen predicts survival in advanced non-small-cell lung cancer treated with cisplatin-based chemotherapy.
Neoplasms
In Silico Targeting Human Multidrug Transporter ABCG2 in Breast Cancer: Database Screening, Molecular Docking, and Molecular Dynamics Study.
Neoplasms
In-depth proteome analysis of the rubber particle of Hevea brasiliensis (para rubber tree).
Neoplasms
Inhibition of breast cancer resistance protein (ABCG2) in human myeloid dendritic cells induces potent tolerogenic functions during LPS stimulation.
Neoplasms
Inhibition of Snail Family Transcriptional Repressor 2 (SNAI2) Enhances Multidrug Resistance of Hepatocellular Carcinoma Cells.
Neoplasms
Integrated analysis of transcriptomic and metabolomic data demonstrates the significant role of pyruvate carboxylase in the progression of ovarian cancer.
Neoplasms
Integration of gene expression and methylation to unravel biological networks in glioblastoma patients.
Neoplasms
Interaction of tomato lectin with ABC transporter in cancer cells: Glycosylation confers functional conformation of P-gp.
Neoplasms
Interactions of cyclin-dependent kinase inhibitors AT-7519, flavopiridol and SNS-032 with ABCB1, ABCG2 and ABCC1 transporters and their potential to overcome multidrug resistance in vitro.
Neoplasms
Kinetic characterization of ribozymes directed against the cisplatin resistance-associated ABC transporter cMOAT/MRP2/ABCC2.
Neoplasms
Lack of ABCG2 Shortens Latency of BRCA1-Deficient Mammary Tumors and This Is Not Affected by Genistein or Resveratrol.
Neoplasms
Loss of an ABC transporter in Arabidopsis thaliana confers hypersensitivity to the anti-cancer drug bleomycin.
Neoplasms
MRP2 (ABCC2) and cisplatin sensitivity in hepatocytes and human ovarian carcinoma.
Neoplasms
MRP2 (ABCC2) transports taxanes and confers paclitaxel resistance and both processes are stimulated by probenecid.
Neoplasms
Multi-kinase inhibitors and cisplatin for head and neck cancer treatment in vitro.
Neoplasms
Multidrug Resistance in Mammals and Fungi-From MDR to PDR: A Rocky Road from Atomic Structures to Transport Mechanisms.
Neoplasms
Multiple drug resistance associated with function of ABC-transporters in diabetes mellitus: molecular mechanism and clinical relevance.
Neoplasms
Natural allelic variants of bovine ATP-binding cassette transporter ABCG2: increased activity of the Ser581 variant and development of tools for the discovery of new ABCG2 inhibitors.
Neoplasms
New approach to vital analysis of functional activity in ABC transporters (markers for multidrug resistance) in solid tumors by the method of flow cytofluorometry.
Neoplasms
New uracil analogs as downregulators of ABC transporters in 5-fluorouracil-resistant human leukemia HL-60 cell line.
Neoplasms
Nongenotoxic ABCB1 activator tetraphenylphosphonium can contribute to doxorubicin resistance in MX-1 breast cancer cell line.
Neoplasms
Notch1 signaling contributes to stemness in head and neck squamous cell carcinoma.
Neoplasms
Novel 3,4-Dihydroisocoumarins Inhibit Human P-gp and BCRP in Multidrug Resistant Tumors and Demonstrate Substrate Inhibition of Yeast Pdr5.
Neoplasms
Novel Potent ABCB1 Modulator, Phenethylisoquinoline Alkaloid, Reverses Multidrug Resistance in Cancer Cell.
Neoplasms
Novel steroid carbamates reverse multidrug-resistance in cancer therapy and show linkage among efficacy, loci of drug action and P-glycoprotein's cellular localization.
Neoplasms
Nrf2 signaling promotes cancer stemness, migration, and expression of ABC transporter genes in sorafenib-resistant hepatocellular carcinoma cells.
Neoplasms
Nrf2-dependent induction of human ABC transporter ABCG2 and heme oxygenase-1 in HepG2 cells by photoactivation of porphyrins: biochemical implications for cancer cell response to photodynamic therapy.
Neoplasms
Oligomeric proanthocyanidins (OPCs) from grape seed extract suppress the activity of ABC transporters in overcoming chemoresistance in colorectal cancer cells.
Neoplasms
Overexpression of ABCC3 promotes cell proliferation, drug resistance, and aerobic glycolysis and is associated with poor prognosis in urinary bladder cancer patients.
Neoplasms
PCI29732, a Bruton's Tyrosine Kinase Inhibitor, Enhanced the Efficacy of Conventional Chemotherapeutic Agents in ABCG2-Overexpressing Cancer Cells.
Neoplasms
PET and SPECT Radiotracers to Assess Function and Expression of ABC Transporters in Vivo.
Neoplasms
Pharmacogenomics of the human ABC transporter ABCG2: from functional evaluation to drug molecular design.
Neoplasms
Phytoestrogen Suppresses Efflux of the Diagnostic Marker Protoporphyrin IX in Lung Carcinoma.
Neoplasms
Predicting drug sensitivity and resistance: profiling ABC transporter genes in cancer cells.
Neoplasms
Priming of pancreatic cancer cells with bispecific antibody armed activated T cells sensitizes tumors for enhanced chemoresponsiveness.
Neoplasms
Protective mechanism of Astragalus Polysaccharides against Cantharidin-induced liver injury determined in vivo by liquid chromatography/mass spectrometry metabolomics.
Neoplasms
PTEN/PI3K/Akt pathway regulates the side population phenotype and ABCG2 activity in glioma tumor stem-like cells.
Neoplasms
Recent Advances in the Studies of Molecular Mechanisms Regulating Multidrug Resistance in Cancer Cells.
Neoplasms
Redirection of carotenoid metabolism for the efficient production of taxadiene [taxa-4(5),11(12)-diene] in transgenic tomato fruit.
Neoplasms
Regulation of ABCG2 expression by Wnt5a through FZD7 in human pancreatic cancer cells.
Neoplasms
Reversing multidrug resistance in breast cancer cells by silencing ABC transporter genes with nanoparticle-facilitated delivery of target siRNAs.
Neoplasms
Role of Nrf2 in cancer photodynamic therapy: Regulation of human ABC transporter ABCG2.
Neoplasms
Silver nanoparticles modulate ABC transporter activity and enhance chemotherapy in multidrug resistant cancer.
Neoplasms
Single nucleotide polymorphisms in the multidrug resistance gene 1 (ABCB1): effects on its expression and clinicopathological characteristics in breast cancer patients.
Neoplasms
Single-nucleotide polymorphisms in a short basic motif in the ABC transporter ABCG2 disable its trafficking out of endoplasmic reticulum and reduce cell resistance to anticancer drugs.
Neoplasms
Squamous cell cancers contain a side population of stem-like cells that are made chemosensitive by ABC transporter blockade.
Neoplasms
Structure of the multidrug ABC transporter Sav1866 from Staphylococcus aureus in complex with AMP-PNP.
Neoplasms
Synthesis and bioevaluation of novel benzodipyranone derivatives as P-glycoprotein inhibitors for multidrug resistance reversal agents.
Neoplasms
Synthesis and biological investigation of 2,4-substituted quinazolines as highly potent inhibitors of breast cancer resistance protein (ABCG2).
Neoplasms
The ABCA2 transporter: intracellular roles in trafficking and metabolism of LDL-derived cholesterol and sterol-related compounds.
Neoplasms
The ATP-binding cassette transporter ABCA2 as a mediator of intracellular trafficking.
Neoplasms
The ATP-binding cassette transporters and their implication in drug disposition: a special look at the heart.
Neoplasms
The Effect of Vitamin D3 and Ketoconazole Combination on VDR-mediated P-gp Expression and Function in Human Colon Adenocarcinoma Cells: Implications in Drug Disposition and Resistance.
Neoplasms
The presence of P-glycoprotein in L1210 cells directly induces down-regulation of cell surface saccharide targets of concanavalin A.
Neoplasms
The Road of Solid Tumor Survival: From Drug-Induced Endoplasmic Reticulum Stress to Drug Resistance.
Neoplasms
The role of microRNA in metastatic colorectal cancer and its significance in cancer prognosis and treatment.
Neoplasms
The structure of the human ABC transporter ABCG2 reveals a novel mechanism for drug extrusion.
Neoplasms
Ultrasound reverses multidrug resistance in human cancer cells by altering gene expression of ABC transporter proteins and Bax protein.
Neoplasms
Y6, an Epigallocatechin Gallate Derivative, Reverses ABCG2-Mediated Mitoxantrone Resistance.
Neoplasms
¹?FDG a PET tumor diagnostic tracer is not a substrate of the ABC transporter P-glycoprotein.
Neoplasms, Squamous Cell
Squamous cell cancers contain a side population of stem-like cells that are made chemosensitive by ABC transporter blockade.
Neuroblastoma
Direct and coordinate regulation of ATP-binding cassette (ABC) transporter genes by MYC factors generates specific transcription signatures which significantly affect the chemoresistance phenotype of cancer cells.
Neuroblastoma
Gangliosides do not affect ABC transporter function in human neuroblastoma cells.
Neuroblastoma
Integration of gene expression and methylation to unravel biological networks in glioblastoma patients.
Neuroblastoma
Nitric oxide control of MYCN expression and multi drug resistance genes in tumours of neural origin.
Neurodegenerative Diseases
Etiology and treatment of adrenoleukodystrophy: new insights from Drosophila.
Neurodegenerative Diseases
Is subclinical adrenal failure in Adrenoleukodystrophy/Adrenomyeloneuropathy (ALD/AMN) reversible?
Neuromyelitis Optica
Aquaporin 4-specific T cells in neuromyelitis optica exhibit a Th17 bias and recognize Clostridium ABC transporter.
Neutropenia
ABC transporter polymorphisms are associated with irinotecan pharmacokinetics and neutropenia.
Ovarian Neoplasms
Adipocytes induce the resistance of ovarian cancer to carboplatin through ANGPTL4.
Ovarian Neoplasms
Integrated analysis of transcriptomic and metabolomic data demonstrates the significant role of pyruvate carboxylase in the progression of ovarian cancer.
Ovarian Neoplasms
Reversal of Chemoresistance in Ovarian Cancer by Co-Delivery of a P-Glycoprotein Inhibitor and Paclitaxel in a Liposomal Platform.
Ovarian Neoplasms
Reversing paclitaxel resistance in ovarian cancer cells via inhibition of the ABCB1 expressing side population.
Ovarian Neoplasms
The role of ABC transporters in ovarian cancer progression and chemoresistance.
Ovarian Neoplasms
The side population of ovarian cancer cells defines a heterogeneous compartment exhibiting stem cell characteristics.
Pancreatic Neoplasms
CD44-positive cells are responsible for gemcitabine resistance in pancreatic cancer cells.
Pancreatic Neoplasms
Dynamic quantitative detection of ABC transporter family promoter methylation by MS-HRM for predicting MDR in pancreatic cancer.
Pancreatic Neoplasms
GRP78-mediated antioxidant response and ABC transporter activity confers chemoresistance to pancreatic cancer cells.
Parkinson Disease
PET and SPECT Radiotracers to Assess Function and Expression of ABC Transporters in Vivo.
Periodontal Diseases
Oxidative stress induces phosphorylation of the ABC transporter, ATP-binding protein, in Porphyromonas gingivalis.
Persistent Infection
Validation of a novel Mho microarray for a comprehensive characterisation of the Mycoplasma hominis action in HeLa cell infection.
Plague
The ABC transporter protein OppA provides protection against experimental Yersinia pestis infection.
Plague
The crystal structure of the Yersinia pestis iron chaperone YiuA reveals a basic triad binding motif for the chelated metal.
Pneumonia
Differential gene expression in Streptococcus pneumoniae in response to various iron sources.
Porphyrias
[Genetic polymorphisms of human ABC transporter ABCG2: Porphyria risk and ER quality control]
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Control of P-glycoprotein activity by membrane cholesterol amounts and their relation to multidrug resistance in human CEM leukemia cells.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Ex vivo resistance in childhood acute lymphoblastic leukemia: Correlations between BCRP, MRP1, MRP4 and MRP5 ABC transporter expression and intracellular methotrexate polyglutamate accumulation.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Resistance to farnesyltransferase inhibitors in Bcr/Abl-positive lymphoblastic leukemia by increased expression of a novel ABC transporter homolog ATP11a.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
The role of ATP-binding cassette transporter A2 in childhood acute lymphoblastic leukemia multidrug resistance.
Prostatic Neoplasms
Discovery of 2-chloro-N-(4-methoxyphenyl)-N-methylquinazolin-4-amine (EP128265, MPI-0441138) as a potent inducer of apoptosis with high in vivo activity.
Prostatic Neoplasms
The 44-kDa Pim-1 kinase phosphorylates BCRP/ABCG2 and thereby promotes its multimerization and drug-resistant activity in human prostate cancer cells.
Pseudoxanthoma Elasticum
Ethnogeographic and inter-individual variability of human ABC transporters.
Pseudoxanthoma Elasticum
Expression of the human ABCC6 gene is induced by retinoids through the retinoid X receptor.
Pseudoxanthoma Elasticum
HNF4alpha and NF-E2 are key transcriptional regulators of the murine Abcc6 gene expression.
Pseudoxanthoma Elasticum
Large-scaled metabolic profiling of human dermal fibroblasts derived from pseudoxanthoma elasticum patients and healthy controls.
Pseudoxanthoma Elasticum
Mutations in a gene encoding an ABC transporter cause pseudoxanthoma elasticum.
Pseudoxanthoma Elasticum
Stabilization of Nucleotide Binding Domain Dimers Rescues ABCC6 Mutants Associated with Pseudoxanthoma Elasticum.
Pseudoxanthoma Elasticum
Subcellular localization and N-glycosylation of human ABCC6, expressed in MDCKII cells.
Pseudoxanthoma Elasticum
The tissue distribution of murine Abcc6 (Mrp6) during embryogenesis indicates that the presence of Abcc6 in elastic tissues is not required for elastic fiber assembly.
Pseudoxanthoma Elasticum
[What can we learn from molecular genetic analyses of inherited eye diseases?]
Pulmonary Disease, Chronic Obstructive
The impact of cigarette smoke exposure, COPD, or asthma status on ABC transporter gene expression in human airway epithelial cells.
Reperfusion Injury
ABC transporter expression profiling after ischemic reperfusion injury in mouse kidney.
Retinal Diseases
Interaction of extracellular domain 2 of the human retina-specific ABC transporter (ABCA4) with all-trans retinal.
Retinal Diseases
Late-onset Stargardt disease is associated with missense mutations that map outside known functional regions of ABCR (ABCA4).
Retinal Dystrophies
Late-onset Stargardt disease is associated with missense mutations that map outside known functional regions of ABCR (ABCA4).
Retinitis Pigmentosa
De novo deletion removes a conserved motif in the C-terminus of ABCA4 and results in cone-rod dystrophy.
Retinitis Pigmentosa
Molecular scanning of the ABCA4 gene in Spanish patients with retinitis pigmentosa and Stargardt disease: Identification of novel mutations.
Retinoblastoma
Characterization of the ATP-binding cassette transporter gene expression profile in Y79: a retinoblastoma cell line.
Sarcoma
Aldehyde dehydrogenase 1, a potential marker for cancer stem cells in human sarcoma.
Sarcoma
Effect of costunolide and dehydrocostus lactone on cell cycle, apoptosis, and ABC transporter expression in human soft tissue sarcoma cells.
Spinocerebellar Ataxias
Cloning and chromosomal mapping of a novel ABC transporter gene (hABC7), a candidate for X-linked sideroblastic anemia with spinocerebellar ataxia.
Squamous Cell Carcinoma of Head and Neck
Expression of ABC transporters is an unfavorable prognostic factor in laryngeal squamous cell carcinoma.
Squamous Cell Carcinoma of Head and Neck
Multi-kinase inhibitors and cisplatin for head and neck cancer treatment in vitro.
Squamous Cell Carcinoma of Head and Neck
Notch1 signaling contributes to stemness in head and neck squamous cell carcinoma.
Staphylococcal Infections
Identification of an immunodominant ABC transporter in methicillin-resistant Staphylococcus aureus infections.
Stargardt Disease
ABCA4 is an N-retinylidene-phosphatidylethanolamine and phosphatidylethanolamine importer.
Stargardt Disease
ABCR: rod photoreceptor-specific ABC transporter responsible for Stargardt disease.
Stargardt Disease
Are microarrays useful in the screening of ABCA4 mutations in Italian patients affected by macular degenerations?
Stargardt Disease
Binding of retinoids to ABCA4, the photoreceptor ABC transporter associated with Stargardt macular degeneration.
Stargardt Disease
Biochemical defects in retina-specific human ATP binding cassette transporter nucleotide binding domain 1 mutants associated with macular degeneration.
Stargardt Disease
De novo deletion removes a conserved motif in the C-terminus of ABCA4 and results in cone-rod dystrophy.
Stargardt Disease
Interaction of extracellular domain 2 of the human retina-specific ABC transporter (ABCA4) with all-trans retinal.
Stargardt Disease
Late-onset Stargardt disease is associated with missense mutations that map outside known functional regions of ABCR (ABCA4).
Stargardt Disease
Mechanistic studies of ABCR, the ABC transporter in photoreceptor outer segments responsible for autosomal recessive Stargardt disease.
Stargardt Disease
Mutational scanning of the ABCR gene with double-gradient denaturing-gradient gel electrophoresis (DG-DGGE) in Italian Stargardt disease patients.
Stargardt Disease
Retinal stimulates ATP hydrolysis by purified and reconstituted ABCR, the photoreceptor-specific ATP-binding cassette transporter responsible for Stargardt disease.
Stargardt Disease
The role of the photoreceptor ABC transporter ABCA4 in lipid transport and Stargardt macular degeneration.
Starvation
RsaC sRNA modulates the oxidative stress response of Staphylococcus aureus during manganese starvation.
Stroke
A single power stroke by ATP binding drives substrate translocation in a heterodimeric ABC transporter.
Stroke
ATP binding to the motor domain from an ABC transporter drives formation of a nucleotide sandwich dimer.
Stroke
Conformational dynamics of the nucleotide binding domains and the power stroke of a heterodimeric ABC transporter.
Stroke
Deactivation of ATP-Binding Cassette Transporters ABCB1 and ABCC1 Does Not Influence Post-ischemic Neurological Deficits, Secondary Neurodegeneration and Neurogenesis, but Induces Subtle Microglial Morphological Changes.
Syphilis
Crystal stuctures of MglB-2 (TP0684), a topologically variant d-glucose-binding protein from Treponema pallidum, reveal a ligand-induced conformational change.
Tangier Disease
Apolipoprotein A-I activates Cdc42 signaling through the ABCA1 transporter.
Tangier Disease
Genetic variation in ABC transporter A1 contributes to HDL cholesterol in the general population.
Thyroid Neoplasms
Influence of CYP3A4/5 and ABC transporter polymorphisms on lenvatinib plasma trough concentrations in Japanese patients with thyroid cancer.
Thyroid Neoplasms
Primary structure of a novel ABC transporter with a chromosomal localization on the band encoding the multidrug resistance-associated protein.
Tuberculosis
ABC transporter ATPase of Chlamydophila pneumoniae as a potential vaccine candidate.
Tuberculosis
An ABC transporter containing a forkhead-associated domain interacts with a serine-threonine protein kinase and is required for growth of Mycobacterium tuberculosis in mice.
Tuberculosis
BacA, an ABC transporter involved in maintenance of chronic murine infections with Mycobacterium tuberculosis.
Tuberculosis
Biochemical and biophysical characterization of nucleotide binding domain of Trehalose transporter from Mycobacterium tuberculosis.
Tuberculosis
Biophysical Characterization of the Tandem FHA Domain Regulatory Module from the Mycobacterium tuberculosis ABC Transporter Rv1747.
Tuberculosis
Comparative Proteomic Analysis of Mycobacterium tuberculosis Lineage 7 and Lineage 4 Strains Reveals Differentially Abundant Proteins Linked to Slow Growth and Virulence.
Tuberculosis
Forkhead-associated (FHA) Domain Containing ABC Transporter Rv1747 Is Positively Regulated by Ser/Thr Phosphorylation in Mycobacterium tuberculosis.
Tuberculosis
Functional genomics reveals the sole sulphate transporter of the Mycobacterium tuberculosis complex and its relevance to the acquisition of sulphur in vivo.
Tuberculosis
Glycine betaine uptake by the ProXVWZ ABC transporter contributes to the ability of Mycobacterium tuberculosis to initiate growth in human macrophages.
Tuberculosis
Identification and characterization of metal uptake ABC transporters in Mycobacterium tuberculosis unveil their ligand specificity.
Tuberculosis
Identification of an ABC transporter required for iron acquisition and virulence in Mycobacterium tuberculosis.
Tuberculosis
Insights on Mycobacterium leprae Efflux Pumps and Their Implications in Drug Resistance and Virulence.
Tuberculosis
Molecular characterisation of ABC transporter type FtsE and FtsX proteins of Mycobacterium tuberculosis.
Tuberculosis
MtFtsX a predicted membrane domain of ABC transporter complex MtFtsEX of Mycobacterium tuberculosis interacts with the cell division protein MtFtsZ.
Tuberculosis
Partial complementation of Sinorhizobium meliloti bacA mutant phenotypes by the Mycobacterium tuberculosis BacA protein.
Tuberculosis
Phase separation and clustering of an ABC transporter in Mycobacterium tuberculosis.
Tuberculosis
Profiling of ABC Transporters During Active Ulcerative Colitis and In Vitro Effect of Inflammatory Modulators.
Tuberculosis
Rv1218c, an ABC transporter of Mycobacterium tuberculosis with implications in drug discovery.
Tuberculosis
Rv1273c, an ABC transporter of Mycobacterium tuberculosis promotes mycobacterial intracellular survival within macrophages via modulating the host cell immune response.
Tuberculosis
Rv2686c-Rv2687c-Rv2688c, an ABC fluoroquinolone efflux pump in Mycobacterium tuberculosis.
Tuberculosis
The ABC transporter Rv1272c of Mycobacterium tuberculosis enhances the import of long-chain fatty acids in Escherichia coli.
Tuberculosis
The Mycobacterium tuberculosis high-affinity iron importer, IrtA, contains an FAD-binding domain.
Tuberculosis
Trehalose-recycling ABC transporter LpqY-SugA-SugB-SugC is essential for virulence of Mycobacterium tuberculosis.
Tuberculosis
Two FHA domains on an ABC transporter, Rv1747, mediate its phosphorylation by PknF, a Ser/Thr protein kinase from Mycobacterium tuberculosis.
Urinary Bladder Neoplasms
Side population in human non-muscle invasive bladder cancer enriches for cancer stem cells that are maintained by MAPK signalling.
Vascular Diseases
Decreased Frequencies of ABCA1 Polymorphisms R219K and V771M in Hungarian Patients with Cerebrovascular and Cardiovascular Diseases.
Virus Diseases
Decreased expression of an ATP-binding cassette transporter, MRP2, in human livers with hepatitis C virus infection.
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ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable).
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable). Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
CRYSTALLIZATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
substrate-binding protein OpuCC in the apo-form and in complex with carnitine, glycine betaine, choline and ectoine to 2.3, 2.7, 2.4, 1.9 and 2.1 A resolution, respectively. OpuCC is composed of two alpha/beta/alpha globular sandwich domains linked by two hinge regions, with a substrate-binding pocket located at the interdomain cleft. Upon substrate binding, the two domains shift towards each other to trap the substrate
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PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
T94D
shares a quite similar pattern of fluorescence spectrum to that of the paralogue OpuBC. Only choline can trigger obvious changes of fluorescence intensity of mutant T94D, whereas carnitine, GB and ectoine cannot
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CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Du, Y.; Shi, W.W.; He, Y.X.; Yang, Y.H.; Zhou, C.Z.; Chen, Y.
Structures of the substrate-binding protein provide insights into the multiple compatible solute binding specificities of the Bacillus subtilis ABC transporter OpuC
Biochem. J.
436
283-289
2011
Bacillus subtilis (O32243), Bacillus subtilis
brenda
EXTERNAL LINKS (specific for EC-Number 7.6.2.9)
Transporter Classification Database (TCDB): 3.A.1.12.2
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Release 2023.1 (January 2023)
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