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Information on EC 7.6.2.3 - ABC-type glutathione-S-conjugate transporter and Organism(s) Arabidopsis thaliana and UniProt Accession Q9C8G9

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IUBMB Comments
A eukaryotic ATP-binding cassette (ABC) type transporter that mediates the transport of glutathione-S-conjugates. The mammalian enzyme, which also transports some glucuronides, exports the substrates out of the cell, while plant and fungal transporters export them into the vacuole. Over-expression confers resistance to anticancer drugs by their efficient exportation in glutathione-S-conjugate form.
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This record set is specific for:
Arabidopsis thaliana
UNIPROT: Q9C8G9
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Word Map
The taxonomic range for the selected organisms is: Arabidopsis thaliana
The enzyme appears in selected viruses and cellular organisms
Synonyms
organic anion transporting polypeptide, rlip76, mrp-1, oatp2, oatp1, abcc5, gsh transporter, hgt1p, multidrug resistance associated protein 2, mrp transporter, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
glutathione S-conjugate pump
-
multidrug resistance-associated protein 1
-
ABCC1
-
-
-
-
glutathione-S-conjugate-translocating ATPase
-
-
-
-
MRP
-
-
-
-
MRP1
-
-
-
-
multidrug resistance-associated protein 1
-
-
-
-
YBT1
-
-
-
-
Ycf1
-
-
-
-
PATHWAY SOURCE
PATHWAYS
-
-, -, -, -, -
SYSTEMATIC NAME
IUBMB Comments
ATP + H2O + glutathione-S-conjugate[side 1] = ADP + phosphate + glutathione-S-conjugate[side 2]
A eukaryotic ATP-binding cassette (ABC) type transporter that mediates the transport of glutathione-S-conjugates. The mammalian enzyme, which also transports some glucuronides, exports the substrates out of the cell, while plant and fungal transporters export them into the vacuole. Over-expression confers resistance to anticancer drugs by their efficient exportation in glutathione-S-conjugate form.
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
ATP + H2O + glutathione disulfide[side 1]
ADP + phosphate + glutathione disulfide[side 2]
show the reaction diagram
-
-
-
?
ATP + H2O + S-(2,4-dinitrophenyl)glutathione[side 1]
ADP + phosphate + S-(2,4-dinitrophenyl)glutathione[side 2]
show the reaction diagram
-
-
-
?
ATP + H2O + S-(cyanidin-3-glucosidyl)glutathione[side 1]
ADP + phosphate + S-(cyanidin-3-glucosidyl)glutathione[side 2]
show the reaction diagram
highest activity
-
-
?
ATP + H2O + S-(metolachlor)glutathione[side 1]
ADP + phosphate + S-(metolachlor)glutathione[side 2]
show the reaction diagram
-
-
-
?
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Mg2+
required in form of Mg2+-ATP
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
metabolism
the enzyme transports glutathione S-conjugates of xenobiotics and endogenous substances, including herbicides and anthocyanins out of the cytosol
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
AB1C_ARATH
1622
14
181927
Swiss-Prot
other Location (Reliability: 3)
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
expressed in Saccharomyces cerevisiae ycf1DELTA mutants
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Lu, Y.; Li, Z.; Rea, P.
AtMRP1 gene of Arabidopsis encodes a glutathione S-conjugate pump Isolation and functional definition of a plant ATP-binding cassette transporter gene
Proc. Natl. Acad. Sci. USA
94
8243-8248
1997
Arabidopsis thaliana (Q9C8G9), Arabidopsis thaliana
Manually annotated by BRENDA team