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Information on EC 7.6.2.3 - ABC-type glutathione-S-conjugate transporter and Organism(s) Mus musculus and UniProt Accession Q8VI47

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IUBMB Comments
A eukaryotic ATP-binding cassette (ABC) type transporter that mediates the transport of glutathione-S-conjugates. The mammalian enzyme, which also transports some glucuronides, exports the substrates out of the cell, while plant and fungal transporters export them into the vacuole. Over-expression confers resistance to anticancer drugs by their efficient exportation in glutathione-S-conjugate form.
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This record set is specific for:
Mus musculus
UNIPROT: Q8VI47
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Word Map
The taxonomic range for the selected organisms is: Mus musculus
The enzyme appears in selected viruses and cellular organisms
Synonyms
organic anion transporting polypeptide, rlip76, mrp-1, oatp2, oatp1, abcc5, gsh transporter, hgt1p, multidrug resistance associated protein 2, mrp transporter, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
multidrug resistance-associated protein 2
-
ABCC1
-
-
-
-
ABCC4
-
-
ATP-dependent efflux pump-multidrug resistance protein 1
-
-
breast cancer resistance protein
-
glutathione-S-conjugate-translocating ATPase
-
-
-
-
MRP
-
-
-
-
MRP4
-
-
multidrug resistance-associated protein 1
-
-
-
-
YBT1
-
-
-
-
Ycf1
-
-
-
-
PATHWAY SOURCE
PATHWAYS
-
-, -, -, -, -
SYSTEMATIC NAME
IUBMB Comments
ATP + H2O + glutathione-S-conjugate[side 1] = ADP + phosphate + glutathione-S-conjugate[side 2]
A eukaryotic ATP-binding cassette (ABC) type transporter that mediates the transport of glutathione-S-conjugates. The mammalian enzyme, which also transports some glucuronides, exports the substrates out of the cell, while plant and fungal transporters export them into the vacuole. Over-expression confers resistance to anticancer drugs by their efficient exportation in glutathione-S-conjugate form.
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
ATP + H2O + glutathione-S-conjugate[side 1]
ADP + phosphate + glutathione-S-conjugate[side 2]
show the reaction diagram
-
-
-
?
ATP + H2O + leukotriene C4[side 1]
ADP + phosphate + leukotriene C4[side 2]
show the reaction diagram
-
-
-
?
ATP + H2O + S-(2,4-dinitrophenyl)glutathione[side 1]
ADP + phosphate + S-(2,4-dinitrophenyl)glutathione[side 2]
show the reaction diagram
-
-
-
?
ATP + H2O + S-(acetaminophen)glutathione[side 1]
ADP + phosphate + S-(acetaminophen)glutathione[side 2]
show the reaction diagram
-
-
-
?
ATP + H2O + S-(arsenite)glutathione[side 1]
ADP + phosphate + S-(arsenite)glutathione[side 2]
show the reaction diagram
-
-
-
?
ATP + H2O + S-(bimanyl)glutathione[side 1]
ADP + phosphate + S-(bimanyl)glutathione[side 2]
show the reaction diagram
-
-
-
?
ATP + H2O + S-(curcuminyl)glutathione[side 1]
ADP + phosphate + S-(curcuminyl)glutathione[side 2]
show the reaction diagram
-
-
-
?
ATP + H2O + S-(deoxyprostaglandin J2)glutathione[side 1]
ADP + phosphate + S-(deoxyprostaglandin J2)glutathione[side 2]
show the reaction diagram
-
-
-
?
ATP + H2O + S-(ethacrynic acid)glutathione[side 1]
ADP + phosphate + S-(ethacrynic acid)glutathione[side 2]
show the reaction diagram
-
-
-
?
ATP + H2O + S-(hydroxynonenyl)glutathione[side 1]
ADP + phosphate + S-(hydroxynonenyl)glutathione[side 2]
show the reaction diagram
-
-
-
?
ATP + H2O + S-(methylfluorescinyl)glutathione[side 1]
ADP + phosphate + S-(methylfluorescinyl)glutathione[side 2]
show the reaction diagram
-
-
-
?
ATP + H2O + S-(methylmercury)glutathione[side 1]
ADP + phosphate + S-(methylmercury)glutathione[side 2]
show the reaction diagram
-
-
-
?
ATP + H2O + S-(N-ethylmaleimidyl)glutathione[side 1]
ADP + phosphate + S-(N-ethylmaleimidyl)glutathione[side 2]
show the reaction diagram
-
-
-
?
ATP + H2O + S-(sulfobromophthaleinyl)glutathione[side 1]
ADP + phosphate + S-(sulfobromophthaleinyl)glutathione[side 2]
show the reaction diagram
-
-
-
?
ATP + H2O + S-decylglutathione[side 1]
ADP + phosphate + S-decylglutathione[side 2]
show the reaction diagram
-
-
-
?
ATP + H2O + S-methylglutathione[side 1]
ADP + phosphate + S-methylglutathione[side 2]
show the reaction diagram
-
-
-
?
ATP + H2O + S-metolachloroglutathione[side 1]
ADP + phosphate + S-metolachloroglutathione[side 2]
show the reaction diagram
-
-
-
?
ATP + H2O + glutathione-S-conjugate[side 1]
ADP + phosphate + glutathione-S-conjugate[side 2]
show the reaction diagram
-
-
-
?
ATP + H2O + leukotriene C4[side 1]
ADP + phosphate + leukotriene C4[side 2]
show the reaction diagram
-
-
-
?
ATP + H2O + S-(2,4-dinitrophenyl)glutathione[side 1]
ADP + phosphate + S-(2,4-dinitrophenyl)glutathione[side 2]
show the reaction diagram
-
-
-
?
ATP + H2O + S-(5-carboxyseminaphtharhodafluor-AM)glutathione[side 1]
ADP + phosphate + S-(5-carboxyseminaphtharhodafluor-AM)glutathione[side 2]
show the reaction diagram
-
-
-
-
?
ATP + H2O + S-(acetaminophen)glutathione[side 1]
ADP + phosphate + S-(acetaminophen)glutathione[side 2]
show the reaction diagram
-
-
-
?
ATP + H2O + S-(arsenite)glutathione[side 1]
ADP + phosphate + S-(arsenite)glutathione[side 2]
show the reaction diagram
-
-
-
?
ATP + H2O + S-(bimanyl)glutathione[side 1]
ADP + phosphate + S-(bimanyl)glutathione[side 2]
show the reaction diagram
-
-
-
?
ATP + H2O + S-(calcein-AM)glutathione[side 1]
ADP + phosphate + S-(calcein-AM)glutathione[side 2]
show the reaction diagram
-
-
-
-
?
ATP + H2O + S-(curcuminyl)glutathione[side 1]
ADP + phosphate + S-(curcuminyl)glutathione[side 2]
show the reaction diagram
-
-
-
?
ATP + H2O + S-(deoxyprostaglandin J2)glutathione[side 1]
ADP + phosphate + S-(deoxyprostaglandin J2)glutathione[side 2]
show the reaction diagram
-
-
-
?
ATP + H2O + S-(ethacrynic acid)glutathione[side 1]
ADP + phosphate + S-(ethacrynic acid)glutathione[side 2]
show the reaction diagram
-
-
-
?
ATP + H2O + S-(hydroxynonenyl)glutathione[side 1]
ADP + phosphate + S-(hydroxynonenyl)glutathione[side 2]
show the reaction diagram
-
-
-
?
ATP + H2O + S-(lead acetyl)glutathione[side 1]
ADP + phosphate + S-(lead acetyl)glutathione[side 2]
show the reaction diagram
-
-
-
-
?
ATP + H2O + S-(methylfluorescinyl)glutathione[side 1]
ADP + phosphate + S-(methylfluorescinyl)glutathione[side 2]
show the reaction diagram
-
-
-
?
ATP + H2O + S-(methylmercury)glutathione[side 1]
ADP + phosphate + S-(methylmercury)glutathione[side 2]
show the reaction diagram
-
-
-
?
ATP + H2O + S-(N-ethylmaleimidyl)glutathione[side 1]
ADP + phosphate + S-(N-ethylmaleimidyl)glutathione[side 2]
show the reaction diagram
-
-
-
?
ATP + H2O + S-(sulfobromophthaleinyl)glutathione[side 1]
ADP + phosphate + S-(sulfobromophthaleinyl)glutathione[side 2]
show the reaction diagram
-
-
-
?
ATP + H2O + S-decylglutathione[side 1]
ADP + phosphate + S-decylglutathione[side 2]
show the reaction diagram
-
-
-
?
ATP + H2O + S-methylglutathione[side 1]
ADP + phosphate + S-methylglutathione[side 2]
show the reaction diagram
-
-
-
?
ATP + H2O + S-metolachloroglutathione[side 1]
ADP + phosphate + S-metolachloroglutathione[side 2]
show the reaction diagram
-
-
-
?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
ATP + H2O + glutathione-S-conjugate[side 1]
ADP + phosphate + glutathione-S-conjugate[side 2]
show the reaction diagram
-
-
-
?
ATP + H2O + glutathione-S-conjugate[side 1]
ADP + phosphate + glutathione-S-conjugate[side 2]
show the reaction diagram
-
-
-
?
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
MK571
-
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
UniProt
Manually annotated by BRENDA team
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
-
and a cell line with lower expression of Mrp1, TM4-sh cell
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
physiological function
the enzyme plays a major role in the hepatic biliary and basolateral excretion of sulfate, glucuronide, and glutathione metabolites
physiological function
the enzyme plays a major role in the hepatic biliary and basolateral excretion of sulfate, glucuronide, and glutathione metabolites
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
MRP2_MOUSE
1543
16
173671
Swiss-Prot
other Location (Reliability: 5)
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
?
-
x * 172000, SDS-PAGE
EXPRESSION
ORGANISM
UNIPROT
LITERATURE
expression levels of mRNA and protein of the mrp1 gene in TM-4 cells are significantly induced by lead
-
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Zamek-Gliszczynski, M.; Hoffmaster, K.; Nezasa, K.; Tallman, M.; Brouwer, K.
Integration of hepatic drug transporters and phase II metabolizing enzymes Mechanisms of hepatic excretion of sulfate, glucuronide, and glutathione metabolites
Eur. J. Pharm. Sci.
27
447-486
2006
Mus musculus, Mus musculus (P04095), Mus musculus (Q7TMS5), Mus musculus (Q8VI47), Homo sapiens (O15438), Homo sapiens (O15439), Homo sapiens (Q92887), Homo sapiens (Q9UNQ0), Rattus norvegicus (Q63120), Rattus norvegicus (Q6QMG6), Rattus norvegicus (Q80W57), Rattus norvegicus (Q88563)
Manually annotated by BRENDA team
Huang, S.; Ye, J.; Yu, J.; Chen, L.; Zhou, L.; Wang, H.; Li, Z.; Wang, C.
The accumulation and efflux of lead partly depend on ATP-dependent efflux pump-multidrug resistance protein 1 and glutathione in testis Sertoli cells
Toxicol. Lett.
226
277-284
2014
Mus musculus
Manually annotated by BRENDA team