Any feedback?
Please rate this page
(enzyme.php)
(0/150)

BRENDA support

BRENDA Home
show all | hide all No of entries

Information on EC 7.6.2.3 - ABC-type glutathione-S-conjugate transporter and Organism(s) Rattus norvegicus and UniProt Accession Q80W57

for references in articles please use BRENDA:EC7.6.2.3
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
EC Tree
IUBMB Comments
A eukaryotic ATP-binding cassette (ABC) type transporter that mediates the transport of glutathione-S-conjugates. The mammalian enzyme, which also transports some glucuronides, exports the substrates out of the cell, while plant and fungal transporters export them into the vacuole. Over-expression confers resistance to anticancer drugs by their efficient exportation in glutathione-S-conjugate form.
Specify your search results
Select one or more organisms in this record: ?
This record set is specific for:
Rattus norvegicus
UNIPROT: Q80W57
Show additional data
Do not include text mining results
Include (text mining) results
Include results (AMENDA + additional results, but less precise)
Word Map
The taxonomic range for the selected organisms is: Rattus norvegicus
The enzyme appears in selected viruses and cellular organisms
Synonyms
organic anion transporting polypeptide, rlip76, mrp-1, oatp2, oatp1, abcc5, gsh transporter, hgt1p, multidrug resistance associated protein 2, mrp transporter, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
breast cancer resistance protein
-
ABCC1
-
-
-
-
ABCC4
Q6QMG6
-
ATP-driven GSH transporter
-
glutathione S-conjugate transporter
-
-
glutathione-S-conjugate-translocating ATPase
-
-
-
-
GSH transporter
-
-
MRP
-
-
-
-
MRP1
-
-
-
-
MRP4
Q6QMG6
-
multidrug resistance-associated protein 1
-
-
-
-
multidrug resistance-associated protein 2
-
organic anion transporting polypeptide
-
-
YBT1
-
-
-
-
Ycf1
-
-
-
-
PATHWAY SOURCE
PATHWAYS
-
-, -, -, -, -
SYSTEMATIC NAME
IUBMB Comments
ATP + H2O + glutathione-S-conjugate[side 1] = ADP + phosphate + glutathione-S-conjugate[side 2]
A eukaryotic ATP-binding cassette (ABC) type transporter that mediates the transport of glutathione-S-conjugates. The mammalian enzyme, which also transports some glucuronides, exports the substrates out of the cell, while plant and fungal transporters export them into the vacuole. Over-expression confers resistance to anticancer drugs by their efficient exportation in glutathione-S-conjugate form.
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
ATP + H2O + glutathione-S-conjugate[side 1]
ADP + phosphate + glutathione-S-conjugate[side 2]
show the reaction diagram
Q63120, Q6QMG6, Q80W57, Q88563
-
-
-
?
ATP + H2O + S-(2,4-dinitrophenyl)glutathione[side 1]
ADP + phosphate + S-(2,4-dinitrophenyl)glutathione[side 2]
show the reaction diagram
Q63120, Q6QMG6, Q80W57, Q88563
-
-
-
?
ATP + H2O + S-(arsenite)glutathione[side 1]
ADP + phosphate + S-(arsenite)glutathione[side 2]
show the reaction diagram
Q63120, Q6QMG6, Q80W57, Q88563
-
-
-
?
ATP + H2O + S-(leukotriene C4)glutathione[side 1]
ADP + phosphate + S-(leukotriene C4)glutathione[side 2]
show the reaction diagram
Q63120, Q6QMG6, Q80W57, Q88563
-
-
-
?
ATP + H2O + S-(methylmercury)glutathione[side 1]
ADP + phosphate + S-(methylmercury)glutathione[side 2]
show the reaction diagram
Q63120, Q6QMG6, Q80W57, Q88563
-
-
-
?
ATP + H2O + S-(sulfobromophthaleinyl)glutathione[side 1]
ADP + phosphate + S-(sulfobromophthaleinyl)glutathione[side 2]
show the reaction diagram
Q63120, Q6QMG6, Q80W57, Q88563
-
-
-
?
ATP + H2O + S-decylglutathione[side 1]
ADP + phosphate + S-decylglutathione[side 2]
show the reaction diagram
Q63120, Q6QMG6, Q80W57, Q88563
-
-
-
?
ATP + H2O + 2,4-dinitrophenyl-S-glutathione[side 1]
ADP + phosphate + 2,4-dinitrophenyl-S-glutathione[side 2]
show the reaction diagram
-
-
-
?
ATP + H2O + glutathione disulfide[side 1]
ADP + phosphate + glutathione disulfide[side 2]
show the reaction diagram
-
-
-
?
ATP + H2O + glutathione-S-conjugate[side 1]
ADP + phosphate + glutathione-S-conjugate[side 2]
show the reaction diagram
ATP + H2O + reduced glutathione[side 1]
ADP + phosphate + reduced glutathione[side 2]
show the reaction diagram
-
-
-
?
ATP + H2O + S-(2,4-dinitrophenyl)glutathione[side 1]
ADP + phosphate + S-(2,4-dinitrophenyl)glutathione[side 2]
show the reaction diagram
ATP + H2O + S-(aflatoxin B1)glutathione[side 1]
ADP + phosphate + S-(aflatoxin B1)glutathione[side 2]
show the reaction diagram
-
-
-
?
ATP + H2O + S-(arsenite)glutathione[side 1]
ADP + phosphate + S-(arsenite)glutathione[side 2]
show the reaction diagram
Q63120, Q6QMG6, Q80W57, Q88563
-
-
-
?
ATP + H2O + S-(leukotriene C4)glutathione[side 1]
ADP + phosphate + S-(leukotriene C4)glutathione[side 2]
show the reaction diagram
Q63120, Q6QMG6, Q80W57, Q88563
-
-
-
?
ATP + H2O + S-(methylmercury)glutathione[side 1]
ADP + phosphate + S-(methylmercury)glutathione[side 2]
show the reaction diagram
Q63120, Q6QMG6, Q80W57, Q88563
-
-
-
?
ATP + H2O + S-(sulfobromophthaleinyl)glutathione[side 1]
ADP + phosphate + S-(sulfobromophthaleinyl)glutathione[side 2]
show the reaction diagram
Q63120, Q6QMG6, Q80W57, Q88563
-
-
-
?
ATP + H2O + S-(vincristinyl)glutathione[side 1]
ADP + phosphate + S-(vincristinyl)glutathione[side 2]
show the reaction diagram
-
-
-
?
ATP + H2O + S-decylglutathione[side 1]
ADP + phosphate + S-decylglutathione[side 2]
show the reaction diagram
Q63120, Q6QMG6, Q80W57, Q88563
-
-
-
?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
ATP + H2O + glutathione-S-conjugate[side 1]
ADP + phosphate + glutathione-S-conjugate[side 2]
show the reaction diagram
Q63120, Q6QMG6, Q80W57, Q88563
-
-
-
?
ATP + H2O + 2,4-dinitrophenyl-S-glutathione[side 1]
ADP + phosphate + 2,4-dinitrophenyl-S-glutathione[side 2]
show the reaction diagram
-
-
-
?
ATP + H2O + glutathione disulfide[side 1]
ADP + phosphate + glutathione disulfide[side 2]
show the reaction diagram
-
-
-
?
ATP + H2O + glutathione-S-conjugate[side 1]
ADP + phosphate + glutathione-S-conjugate[side 2]
show the reaction diagram
ATP + H2O + reduced glutathione[side 1]
ADP + phosphate + reduced glutathione[side 2]
show the reaction diagram
-
-
-
?
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
2-mercaptoethanol
-
dithioerythritol
-
dithiothreitol
noncompetitive inhibition
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
glutathione
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
UniProt
Manually annotated by BRENDA team
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
malfunction
MRP2-deficient rats are unable to transport reduced glutathione into bile
physiological function
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
ABCG2_RAT
657
6
72961
Swiss-Prot
-
EXPRESSION
ORGANISM
UNIPROT
LITERATURE
suppression of enzyme activity in jejunum is observed after intravenous administration of bilirubin and co-administration of bilirubin as well as probenecid or ciclosporin
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Ballatori, N.; Hammond, C.; Cunningham, J.
MRP2-mediated reduced glutathione transport in protection against oxidant stress
Comment. Toxicol.
9
215-228
2003
Rattus norvegicus (Q63120)
-
Manually annotated by BRENDA team
Zamek-Gliszczynski, M.; Hoffmaster, K.; Nezasa, K.; Tallman, M.; Brouwer, K.
Integration of hepatic drug transporters and phase II metabolizing enzymes Mechanisms of hepatic excretion of sulfate, glucuronide, and glutathione metabolites
Eur. J. Pharm. Sci.
27
447-486
2006
Mus musculus, Mus musculus (P04095), Mus musculus (Q7TMS5), Mus musculus (Q8VI47), Homo sapiens (O15438), Homo sapiens (O15439), Homo sapiens (Q92887), Homo sapiens (Q9UNQ0), Rattus norvegicus (Q63120), Rattus norvegicus (Q6QMG6), Rattus norvegicus (Q80W57), Rattus norvegicus (Q88563)
Manually annotated by BRENDA team
Yokooji, T.; Murakami, T.; Ogawa, K.; Yumoto, R.; Nagai, J.; Takano, M.
Modulation of intestinal transport of 2,4-dinitrophenyl-S-glutathione, a multidrug resistance-associated protein 2 substrate, by bilirubin treatment in rats
J. Pharm. Pharmacol.
57
579-585
2005
Rattus norvegicus (Q63120)
Manually annotated by BRENDA team
Ballatori, N.; Hammond, C.; Cunningham, J.; Krance, S.; Marchan, R.
Molecular mechanisms of reduced glutathione transport Role of the MRP/CFTR/ABCC and OATP/SLC21A families of membrane proteins
Toxicol. Appl. Pharmacol.
204
238-255
2005
Saccharomyces cerevisiae, Rattus norvegicus, Homo sapiens (O15439), Homo sapiens (O15440), Homo sapiens (P33527), Homo sapiens (Q92887), Homo sapiens
Manually annotated by BRENDA team