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Information on EC 7.6.2.3 - ABC-type glutathione-S-conjugate transporter
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7.6.2.3 ABC-type glutathione-S-conjugate transporterIUBMB Comments
A eukaryotic ATP-binding cassette (ABC) type transporter that mediates the transport of glutathione-S-conjugates. The mammalian enzyme, which also transports some glucuronides, exports the substrates out of the cell, while plant and fungal transporters export them into the vacuole. Over-expression confers resistance to anticancer drugs by their efficient exportation in glutathione-S-conjugate form.
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Word Map
- 7.6.2.3
-
oatps
- hepatocytes
-
resistance-associated
-
disposition
-
drug-drug
-
basolateral
- taurocholate
- biliary
-
cotransporting
- rosuvastatin
- statins
- estrone-3-sulfate
-
sinusoidal
-
anion-transporting
- cyp3a4
- atorvastatin
- digoxin
- cholestasis
-
hepatobiliary
-
transporter-mediated
-
slco1b1
-
concentration-time
- fexofenadine
-
pregnane
-
sodium-independent
- ugt1a1
-
pitavastatin
- sulfobromophthalein
- bromosulfophthalein
-
multispecific
-
na+-independent
- probenecid
- oct1
-
cis-inhibition
-
androstane
- cerivastatin
- coproporphyrins
-
auc0-infinity
-
hyperbilirubinemic
-
perpetrator
-
sandwich-cultured
-
gadoxetic
-
mdckii
-
acid-enhanced
-
eisai
- abcc10
-
dnp-sg
- repaglinide
-
p-aminohippurate
- cyp2c8
The enzyme appears in viruses and cellular organisms
Reaction Schemes
Synonyms
organic anion transporting polypeptide, rlip76, mrp-1, oatp2, oatp1, abcc5, gsh transporter, hgt1p, multidrug resistance associated protein 2, mrp transporter, 
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
ABCC1
-
-
-
-
glutathione-S-conjugate-translocating ATPase
-
-
-
-
MRP
-
-
-
-
MRP1
-
-
-
-
multidrug resistance-associated protein 1
-
-
-
-
YBT1
-
-
-
-
Ycf1
-
-
-
-
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PATHWAY SOURCE
PATHWAYS
-
-, -, -, -, -
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SYSTEMATIC NAME
IUBMB Comments
ATP + H2O + glutathione-S-conjugate[side 1] = ADP + phosphate + glutathione-S-conjugate[side 2]
A eukaryotic ATP-binding cassette (ABC) type transporter that mediates the transport of glutathione-S-conjugates. The mammalian enzyme, which also transports some glucuronides, exports the substrates out of the cell, while plant and fungal transporters export them into the vacuole. Over-expression confers resistance to anticancer drugs by their efficient exportation in glutathione-S-conjugate form.
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
ATP + H2O + glutathione-S-conjugate[side 1]
ADP + phosphate + glutathione-S-conjugate[side 2]
-
-
-
?
ATP + H2O + leukotriene C4[side 1]
ADP + phosphate + leukotriene C4[side 2]
-
-
-
?
ATP + H2O + S-(2,4-dinitrophenyl)glutathione[side 1]
ADP + phosphate + S-(2,4-dinitrophenyl)glutathione[side 2]
-
-
-
?
ATP + H2O + S-(acetaminophen)glutathione[side 1]
ADP + phosphate + S-(acetaminophen)glutathione[side 2]
-
-
-
?
ATP + H2O + S-(arsenite)glutathione[side 1]
ADP + phosphate + S-(arsenite)glutathione[side 2]
-
-
-
?
ATP + H2O + S-(bimanyl)glutathione[side 1]
ADP + phosphate + S-(bimanyl)glutathione[side 2]
-
-
-
?
ATP + H2O + S-(curcuminyl)glutathione[side 1]
ADP + phosphate + S-(curcuminyl)glutathione[side 2]
-
-
-
?
ATP + H2O + S-(deoxyprostaglandin J2)glutathione[side 1]
ADP + phosphate + S-(deoxyprostaglandin J2)glutathione[side 2]
-
-
-
?
ATP + H2O + S-(ethacrynic acid)glutathione[side 1]
ADP + phosphate + S-(ethacrynic acid)glutathione[side 2]
-
-
-
?
ATP + H2O + S-(hydroxynonenyl)glutathione[side 1]
ADP + phosphate + S-(hydroxynonenyl)glutathione[side 2]
-
-
-
?
ATP + H2O + S-(methylfluorescinyl)glutathione[side 1]
ADP + phosphate + S-(methylfluorescinyl)glutathione[side 2]
-
-
-
?
ATP + H2O + S-(methylmercury)glutathione[side 1]
ADP + phosphate + S-(methylmercury)glutathione[side 2]
-
-
-
?
ATP + H2O + S-(N-ethylmaleimidyl)glutathione[side 1]
ADP + phosphate + S-(N-ethylmaleimidyl)glutathione[side 2]
-
-
-
?
ATP + H2O + S-(sulfobromophthaleinyl)glutathione[side 1]
ADP + phosphate + S-(sulfobromophthaleinyl)glutathione[side 2]
-
-
-
?
ATP + H2O + S-decylglutathione[side 1]
ADP + phosphate + S-decylglutathione[side 2]
-
-
-
?
ATP + H2O + S-methylglutathione[side 1]
ADP + phosphate + S-methylglutathione[side 2]
-
-
-
?
ATP + H2O + S-metolachloroglutathione[side 1]
ADP + phosphate + S-metolachloroglutathione[side 2]
-
-
-
?
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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
ATP + H2O + glutathione-S-conjugate[side 1]
ADP + phosphate + glutathione-S-conjugate[side 2]
-
-
-
?
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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Acute Kidney Injury
Downregulated expression of organic anion transporting polypeptide (Oatp) 2b1 in the small intestine of rats with acute kidney injury.
Acute Kidney Injury
MRP-1 expression levels determine strain-specific susceptibility to sodium arsenic-induced renal injury between C57BL/6 and BALB/c mice.
Adenocarcinoma
A study on the correlations of MRP-1 expression with the pathogenesis and prognosis of colorectal cancer.
Adenocarcinoma
Genome-wide association studies in oesophageal adenocarcinoma and Barrett's oesophagus: a large-scale meta-analysis.
Adenocarcinoma
High pretherapeutic thymidylate synthetase and MRP-1 protein levels are associated with nonresponse to neoadjuvant chemotherapy in oesophageal adenocarcinoma patients.
Adenoma
A study on the correlations of MRP-1 expression with the pathogenesis and prognosis of colorectal cancer.
Adenoma, Liver Cell
Morphologic and Molecular Features of Hepatocellular Adenoma with Gadoxetic Acid-enhanced MR Imaging.
Alzheimer Disease
Comment on "Expression of Oatp2 in the Brain and Liver of Alzheimer Disease Mouse Model".
Alzheimer Disease
Expression of Oatp2 in the Brain and Liver of Alzheimer Disease Mouse Model.
Alzheimer Disease
Response to Comment on "Expression of Oatp2 in the Brain and Liver of Alzheimer Disease Mouse Model".
Anaplasmosis
Repression of tick microRNA-133 induces organic anion transporting polypeptide expression critical for Anaplasma phagocytophilum survival in the vector and transmission to the vertebrate host.
Arthritis, Rheumatoid
Acquired resistance to chloroquine in human CEM T cells is mediated by multidrug resistance-associated protein 1 and provokes high levels of cross-resistance to glucocorticoids.
Arthritis, Rheumatoid
MDR-1 and MRP-1 activity in peripheral blood leukocytes of rheumatoid arthritis patients.
Asthma
SLCO2B1 c.935G>A single nucleotide polymorphism has no effect on the pharmacokinetics of montelukast and aliskiren.
Astrocytoma
P-glycoprotein and multidrug resistance-associated protein mediate specific patterns of multidrug resistance in malignant glioma cell lines, but not in primary glioma cells.
Atherosclerosis
Autoantibodies to the C-terminal subunit of RLIP76 induce oxidative stress and endothelial cell apoptosis in immune-mediated vascular diseases and atherosclerosis.
Blast Crisis
High levels of BAX, low levels of MRP-1, and high platelets are independent predictors of response to imatinib in myeloid blast crisis of CML.
Bone Resorption
ABCC5 supports osteoclast formation and promotes breast cancer metastasis to bone.
Brain Neoplasms
Expression and functional activity of the ABC-transporter proteins P-glycoprotein and multidrug-resistance protein 1 in human brain tumor cells and astrocytes.
Breast Neoplasms
2'-Hydroxyflavanone inhibits in vitro and in vivo growth of breast cancer cells by targeting RLIP76.
Breast Neoplasms
ABCC5 supports osteoclast formation and promotes breast cancer metastasis to bone.
Breast Neoplasms
Alterations in Hepatic mRNA Expression of Phase-II Enzymes and Xenobiotic Transporters after Targeted Disruption of Hepatocyte Nuclear Factor 4 alpha.
Breast Neoplasms
Antiretroviral drug transporters and metabolic enzymes in human testicular tissue: potential contribution to HIV-1 sanctuary site.
Breast Neoplasms
Application of Human Placental Villous Tissue Explants to Study ABC Transporter Mediated Efflux of 2,4-Dinitrophenyl-S-Glutathione.
Breast Neoplasms
Bcrp1;Mdr1a/b;Mrp2 combination knockout mice: altered disposition of the dietary carcinogen PhIP (2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine) and its genotoxic metabolites.
Breast Neoplasms
Circumvention of the multidrug-resistance protein (MRP-1) by an antitumor drug through specific inhibition of gene transcription in breast tumor cells.
Breast Neoplasms
Clinical Drug-Drug Interaction Potential of BFE1224, Prodrug of Antifungal Ravuconazole, Using Two Types of Cocktails in Healthy Subjects.
Breast Neoplasms
Conditionally immortalized syncytiotrophoblast cell lines as new tools for study of the blood-placenta barrier.
Breast Neoplasms
Contribution of Uptake and Efflux Transporters to Oral Pharmacokinetics of Furosemide.
Breast Neoplasms
Correction to: Human drug efflux transporter ABCC5 confers acquired resistance to pemetrexed in breast cancer.
Breast Neoplasms
Decreased exposure of simvastatin and simvastatin acid in a rat model of type 2 diabetes.
Breast Neoplasms
Defying Multidrug Resistance! Modulation of Related Transporters by Flavonoids and Flavonolignans.
Breast Neoplasms
Development of liposomal pemetrexed for enhanced therapy against multidrug resistance mediated by ABCC5 in breast cancer.
Breast Neoplasms
Differential regulation of drug transporter expression by all-trans retinoic acid in hepatoma HepaRG cells and human hepatocytes.
Breast Neoplasms
Down-regulation of organic anion transporter expression in human hepatocytes exposed to the proinflammatory cytokine interleukin 1beta.
Breast Neoplasms
Drug transporters in the lung--do they play a role in the biopharmaceutics of inhaled drugs?
Breast Neoplasms
Drug-drug interaction potential and clinical pharmacokinetics of enerisant, a novel potent and selective histamine H3 receptor antagonist.
Breast Neoplasms
Effect of Upadacitinib on the Pharmacokinetics of Rosuvastatin or Atorvastatin in Healthy Subjects.
Breast Neoplasms
Elucidation of the biochemical basis for a clinical drug-drug interaction between atorvastatin and 5-(N-(4-((4-ethylbenzyl)thio)phenyl)sulfamoyl)-2-methyl benzoic acid (CP-778?875), a subtype selective agonist of the peroxisome proliferator-activated receptor alpha.
Breast Neoplasms
Evaluation of Proposed In Vivo Probe Substrates and Inhibitors for Phenotyping Transporter Activity in Humans.
Breast Neoplasms
Examination of Physiologically-Based Pharmacokinetic Models of Rosuvastatin.
Breast Neoplasms
Expression and regulation of breast cancer resistance protein and multidrug resistance associated protein 2 in BALB/c mice.
Breast Neoplasms
Genetic variability in the multidrug resistance associated protein-1 (ABCC1/MRP1) predicts hematological toxicity in breast cancer patients receiving (neo-)adjuvant chemotherapy with 5-fluorouracil, epirubicin and cyclophosphamide (FEC).
Breast Neoplasms
Higher clearance of micafungin in neonates compared with adults: role of age-dependent micafungin serum binding.
Breast Neoplasms
Highly expressed SLCO1B3 inhibits the occurrence and development of breast cancer and can be used as a clinical indicator of prognosis.
Breast Neoplasms
Human drug efflux transporter ABCC5 confers acquired resistance to pemetrexed in breast cancer.
Breast Neoplasms
Identification of molecular markers for metastasis-related genes in primary breast cancer cells.
Breast Neoplasms
Impact of fedratinib on the pharmacokinetics of transporter probe substrates using a cocktail approach.
Breast Neoplasms
Impact of genetic polymorphisms of transporters on the pharmacokinetic, pharmacodynamic and toxicological properties of anionic drugs.
Breast Neoplasms
In vitro evaluation of potential drug interactions mediated by cytochrome P450 and transporters for luseogliflozin, an SGLT2 inhibitor.
Breast Neoplasms
In Vitro Inhibitory Effects of APINACA on Human Major Cytochrome P450, UDP-Glucuronosyltransferase Enzymes, and Drug Transporters.
Breast Neoplasms
In Vitro Interaction of AB-FUBINACA with Human Cytochrome P450, UDP-Glucuronosyltransferase Enzymes and Drug Transporters.
Breast Neoplasms
Induction of multidrug resistance associated protein 2 in tamoxifen-resistant breast cancer cells.
Breast Neoplasms
Influence of ABCC2, SLCO1B1, and ABCG2 polymorphisms on the pharmacokinetics of olmesartan.
Breast Neoplasms
Influence of biliary cirrhosis on the detoxification and elimination of a food derived carcinogen.
Breast Neoplasms
Inhibition of Breast Cancer Resistance Protein and Multidrug Resistance Associated Protein 2 by Natural Compounds and Their Derivatives.
Breast Neoplasms
Interactions of bilastine, a new oral H? antihistamine, with human transporter systems.
Breast Neoplasms
Intestinal absorption mechanism of mirabegron, a potent and selective ??-adrenoceptor agonist: involvement of human efflux and/or influx transport systems.
Breast Neoplasms
Intestinal transport of sophocarpine across the Caco-2 cell monolayer model and quantification by LC/MS.
Breast Neoplasms
Intratumoral morphological heterogeneity of breast cancer: neoadjuvant chemotherapy efficiency and multidrug resistance gene expression.
Breast Neoplasms
Investigation of MRP-1 protein and MDR-1 P-glycoprotein expression in invasive breast cancer: a prognostic study.
Breast Neoplasms
Involvement of miR-326 in chemotherapy resistance of breast cancer through modulating expression of multidrug resistance-associated protein 1.
Breast Neoplasms
Isolation of endothelial cells, pericytes and astrocytes from mouse brain.
Breast Neoplasms
Lack of Interactions Between an Antisense Oligonucleotide with 2'-O-(2-Methoxyethyl) Modifications and Major Drug Transporters.
Breast Neoplasms
Lack of prognostic significance of survivin, survivin-deltaEx3, survivin-2B, galectin-3, bag-1, bax-alpha and MRP-1 mRNAs in breast cancer.
Breast Neoplasms
Lapatinib sensitizes quiescent MDA-MB-231 breast cancer cells to doxorubicin by inhibiting the expression of multidrug resistance-associated protein-1.
Breast Neoplasms
Lung resistance-related protein/major vault protein and vaults in multidrug-resistant cancer.
Breast Neoplasms
Navigating Transporter Sciences in Pharmacokinetics Characterization Using Extended Clearance Classification System (ECCS).
Breast Neoplasms
Nose-to-Brain Delivery of Antiviral Drugs: A Way to Overcome Their Active Efflux?
Breast Neoplasms
Organic anion transporter 3- and organic anion transporting polypeptides 1B1- and 1B3-mediated transport of catalposide.
Breast Neoplasms
Organic anion transporting polypeptide 2B1 and breast cancer resistance protein interact in the transepithelial transport of steroid sulfates in human placenta.
Breast Neoplasms
Organic anion transporting polypeptide 2B1 expression correlates with uptake of estrone-3-sulfate and cell proliferation in estrogen receptor-positive breast cancer cells.
Breast Neoplasms
P-glycoprotein, multidrug resistance-associated proteins and human organic anion transporting polypeptide influence the intracellular accumulation of atazanavir.
Breast Neoplasms
Pharmacogenetics of ABCB5, ABCC5 and RLIP76 and doxorubicin pharmacokinetics in Asian breast cancer patients.
Breast Neoplasms
Pharmacogenetics of target genes across doxorubicin disposition pathway: a review.
Breast Neoplasms
Pharmacokinetics of cobicistat boosted-elvitegravir administered in combination with rosuvastatin.
Breast Neoplasms
Potential of the novel antiretroviral drug rilpivirine to modulate the expression and function of drug transporters and drug-metabolising enzymes in vitro.
Breast Neoplasms
Quantitative membrane protein expression at the blood-brain barrier of adult and younger cynomolgus monkeys.
Breast Neoplasms
Quantitative Prediction of Interactions Mediated by Transporters and Cytochromes: Application to Organic Anion Transporting Polypeptides, Breast Cancer Resistance Protein and Cytochrome 2C8.
Breast Neoplasms
Scaling Down of a Clinical Three-Dimensional Perfusion Multicompartment Hollow Fiber Liver Bioreactor Developed for Extracorporeal Liver Support to an Analytical Scale Device Useful for Hepatic Pharmacological In Vitro Studies.
Breast Neoplasms
The 4'-O-benzylated doxorubicin analog WP744 overcomes resistance mediated by P-glycoprotein, multidrug resistance protein and breast cancer resistance protein in cell lines and acute myeloid leukemia cells.
Breast Neoplasms
The bioavailability and distribution of trans-resveratrol are constrained by ABC transporters.
Breast Neoplasms
The effect of IL-1? on MRP2 expression and tamoxifen toxicity in MCF-7 breast cancer cells.
Breast Neoplasms
The farnesoid X receptor is expressed in breast cancer and regulates apoptosis and aromatase expression.
Breast Neoplasms
The interactions of lenalidomide with human uptake and efflux transporters and UDP-glucuronosyltransferase 1A1: lack of potential for drug-drug interactions.
Breast Neoplasms
The proteins FABP7 and OATP2 are associated with the basal phenotype and patient outcome in human breast cancer.
Breast Neoplasms
The role of pregnane x receptor in 2-acetylaminofluorene-mediated induction of drug transport and -metabolizing enzymes in mice.
Breast Neoplasms
Tissue Distribution, Ontogeny, and Hormonal Regulation of Xenobiotic Transporters in Mouse Kidneys.
Breast Neoplasms
Translation of In Vitro Transport Inhibition Studies to Clinical Drug-Drug Interactions for Glecaprevir and Pibrentasvir.
Breast Neoplasms
Uptake transporter organic anion transporting polypeptide 1B3 contributes to the growth of estrogen-dependent breast cancer.
Breast Neoplasms
USE OF TRANSPORTER KNOCKDOWN CACO-2 CELLS TO INVESTIGATE THE IN VITRO EFFLUX OF STATIN DRUGS.
Breast Neoplasms
Usefulness of novobiocin as a selective inhibitor of intestinal breast cancer resistance protein (Bcrp) in rats.
Breast Neoplasms
Using Ex Vivo Porcine Jejunum to Identify Membrane Transporter Substrates: A Screening Tool for Early-Stage Drug Development.
Breast Neoplasms
[131I]MIBG exports via MRP transporters and inhibition of the MRP transporters improves accumulation of [131I]MIBG in neuroblastoma.
Carcinogenesis
Emerging treatments in lung cancer - targeting the RLIP76 molecular transporter.
Carcinogenesis
Glutathione-conjugate transport by RLIP76 is required for clathrin-dependent endocytosis and chemical carcinogenesis.
Carcinogenesis
RALBP1/RLIP76 depletion in mice suppresses tumor growth by inhibiting tumor neovascularization.
Carcinogenesis
RLIP76 is overexpressed in human glioblastomas and is required for proliferation, tumorigenesis and suppression of apoptosis.
Carcinogenesis
The structure of the RLIP76 RhoGAP-Ral binding domain dyad: fixed position of the domains leads to dual engagement of small G proteins at the membrane.
Carcinogenesis
[Expression of KAI1, MRP-1, and FAK proteins in lung cancer detected by high-density tissue microarray]
Carcinoma
Expression of multidrug resistance markers ABCB1 (MDR-1/P-gp) and ABCC1 (MRP-1) in renal cell carcinoma.
Carcinoma
MRP-1 protein expression and glutathione content of in vitro tumor cell lines derived from human glioma carcinoma U-87-MG do not interact with 99mTc-glucarate uptake.
Carcinoma
Phosphatidylinositol 3'-kinase activation leads to multidrug resistance protein-1 expression and subsequent chemoresistance in advanced prostate cancer cells.
Carcinoma
RLIP76 regulates HIF-1 activity, VEGF expression and secretion in tumor cells, and secretome transactivation of endothelial cells.
Carcinoma
RLIP76 transports sunitinib and sorafenib and mediates drug resistance in kidney cancer.
Carcinoma
[Expression of ATP-binding cassette transporter genes in nasopharyngeal carcinoma.]
Carcinoma, Hepatocellular
Differential regulation of drug transporter expression by all-trans retinoic acid in hepatoma HepaRG cells and human hepatocytes.
Carcinoma, Hepatocellular
Gadoxetic acid-enhanced magnetic resonance imaging reflects co-activation of ?-catenin and hepatocyte nuclear factor 4? in hepatocellular carcinoma.
Carcinoma, Hepatocellular
Pan-cancer analysis and single-cell analysis revealed the role of ABCC5 transporter in hepatocellular carcinoma.
Carcinoma, Hepatocellular
The human organic anion transporting polypeptide 8 (SLCO1B3) gene is transcriptionally repressed by hepatocyte nuclear factor 3beta in hepatocellular carcinoma.
Carcinoma, Mucoepidermoid
Nuclear Multidrug-Resistance Related Protein 1 Contributes to Multidrug-Resistance of Mucoepidermoid Carcinoma Mainly via Regulating Multidrug-Resistance Protein 1: A Human Mucoepidermoid Carcinoma Cells Model and Spearman's Rank Correlation Analysis.
Carcinoma, Non-Small-Cell Lung
ABCC5, ERCC2, XPA and XRCC1 transcript abundance levels correlate with cisplatin chemoresistance in non-small cell lung cancer cell lines.
Carcinoma, Non-Small-Cell Lung
Depletion of RLIP76 sensitizes lung cancer cells to doxorubicin.
Carcinoma, Non-Small-Cell Lung
Folic acid (FA)-conjugated mesoporous silica nanoparticles combined with MRP-1 siRNA improves the suppressive effects of myricetin on non-small cell lung cancer (NSCLC).
Carcinoma, Non-Small-Cell Lung
MDR1/P-glycoprotein and MRP-1 mRNA and protein expression in non-small cell lung cancer.
Carcinoma, Non-Small-Cell Lung
Multidrug resistance markers P-glycoprotein, multidrug resistance protein 1, and lung resistance protein in non-small cell lung cancer: prognostic implications.
Carcinoma, Non-Small-Cell Lung
RLIP76 transports vinorelbine and mediates drug resistance in non-small cell lung cancer.
Carcinoma, Non-Small-Cell Lung
The determinants of sensitivity and acquired resistance to gemcitabine differ in non-small cell lung cancer: a role of ABCC5 in gemcitabine sensitivity.
Carcinoma, Non-Small-Cell Lung
[Expression of KAI1, MRP-1, and FAK proteins in lung cancer detected by high-density tissue microarray]
Carcinoma, Renal Cell
Expression of multidrug resistance markers ABCB1 (MDR-1/P-gp) and ABCC1 (MRP-1) in renal cell carcinoma.
Carcinoma, Renal Cell
RLIP76 transports sunitinib and sorafenib and mediates drug resistance in kidney cancer.
Cardiotoxicity
Polymorphisms of ABCC5 and NOS3 genes influence doxorubicin cardiotoxicity in survivors of childhood acute lymphoblastic leukemia.
Chemical and Drug Induced Liver Injury
Drug interaction study of flavonoids toward OATP1B1 and their 3D structure activity relationship analysis for predicting hepatoprotective effects.
Cholangitis
Regulation of organic anion transporters in a new rat model of acute and chronic cholangitis resembling human primary sclerosing cholangitis.
Cholangitis, Sclerosing
Expression of hepatic transporters OATP-C and MRP2 in primary sclerosing cholangitis.
Cholestasis
Characterization of the mechanisms involved in the increased renal elimination of bromosulfophthalein during cholestasis: involvement of oatp1.
Cholestasis
Dioscin protects against ANIT-induced cholestasis via regulating Oatps, Mrp2 and Bsep expression in rats.
Cholestasis
Effect of Yin-Zhi-Huang on up-regulation of Oatp2, Ntcp, and Mrp2 proteins in estrogen-induced rat cholestasis.
Cholestasis
Growth hormone modulation of the rat hepatic bile transporter system in endotoxin-induced cholestasis.
Cholestasis
Hepatobiliary transporter expression in percutaneous liver biopsies of patients with cholestatic liver diseases.
Cholestasis
Hepatocyte growth factor increases uptake of estradiol 17beta-D-glucuronide and Oatp1 protein level in rat hepatocytes.
Cholestasis
Maternal cholestasis does not affect the ontogenic pattern of expression of the Na+/taurocholate cotransporting polypeptide (ntcp) in the fetal and neonatal rat liver.
Cholestasis
Nuclear receptors constitutive androstane receptor and pregnane X receptor ameliorate cholestatic liver injury.
Cholestasis
Regulation of basolateral organic anion transporters in ethinylestradiol-induced cholestasis in the rat.
Cholestasis
Regulation of organic anion transporters in a new rat model of acute and chronic cholangitis resembling human primary sclerosing cholangitis.
Cholestasis
Regulation of rat organic anion transporters in bile salt-induced cholestatic hepatitis: effect of ursodeoxycholate.
Cholestasis, Extrahepatic
Expression and function of renal and hepatic organic anion transporters in extrahepatic cholestasis.
Cholestasis, Extrahepatic
Extrahepatic cholestasis downregulates Oatp1 by TNF-alpha signalling without affecting Oatp2 and Oatp4 expression and sodium-independent bile salt uptake in rat liver.
Cholestasis, Intrahepatic
Bile acid transport correlative protein mRNA expression profile in human placenta with intrahepatic cholestasis of pregnancy.
Colonic Neoplasms
Correlation between Gd-EOB-DTPA-enhanced MR imaging findings and OATP1B3 expression in chemotherapy-associated sinusoidal obstruction syndrome.
Colonic Neoplasms
Cyclooxygenase-2 gene induction causes CDDP resistance in colon cancer cell line, HCT-15.
Colonic Neoplasms
Regression of lung and colon cancer xenografts by depleting or inhibiting RLIP76 (Ral-binding protein 1).
Colonic Neoplasms
RLIP76 blockade by siRNA inhibits proliferation, enhances apoptosis, and suppresses invasion in HT29 colon cancer cells.
Colorectal Neoplasms
A study on the correlations of MRP-1 expression with the pathogenesis and prognosis of colorectal cancer.
Colorectal Neoplasms
ABCC5 and ABCG1 polymorphisms predict irinotecan-induced severe toxicity in metastatic colorectal cancer patients.
Colorectal Neoplasms
CAC1 knockdown reverses drug resistance through the downregulation of P-gp and MRP-1 expression in colorectal cancer.
Colorectal Neoplasms
Cancer-type OATP1B3 mRNA has the potential to become a detection and prognostic biomarker for human colorectal cancer.
Colorectal Neoplasms
Cancer-type organic anion transporting polypeptide 1B3 is a target for cancer suicide gene therapy using RNA trans-splicing technology.
Colorectal Neoplasms
Clinical utility of ABCB1 genotyping for preventing toxicity in treatment with irinotecan.
Colorectal Neoplasms
Downregulation of RLIP76 is associated with vincristine resistance in human colorectal cancer HCT-8/VCR cells.
Colorectal Neoplasms
Influence of the Functional Polymorphisms in the Organic Anion Transporting Polypeptide 1B1 in the Susceptibility to Colorectal Cancer.
Colorectal Neoplasms
miR-340 suppresses tumor growth and enhances chemosensitivity of colorectal cancer by targeting RLIP76.
Colorectal Neoplasms
Organic anion transporting polypeptide 1B3 (OATP1B3) is overexpressed in colorectal tumors and is a predictor of clinical outcome.
Colorectal Neoplasms
Single nucleotide polymorphisms of ABCC5 and ABCG1 transporter genes correlate to irinotecan-associated gastrointestinal toxicity in colorectal cancer patients: a DMET microarray profiling study.
Congenital Abnormalities
Adenosine triphosphate-dependent copper transport in isolated rat liver plasma membranes.
Diabetes Mellitus, Type 2
Abcc5 Knockout Mice Have Lower Fat Mass and Increased Levels of Circulating GLP-1.
Diabetes Mellitus, Type 2
ABCC5 transporter is a novel type 2 diabetes susceptibility gene in European and African American populations.
Drug Resistant Epilepsy
Drug transporters are altered in brain, liver and kidney of rats with chronic epilepsy induced by lithium-pilocarpine.
Drug Resistant Epilepsy
miR-23a-3p is involved in drug resistance by directly targeting the influx drug transporter organic anion-transporting polypeptide 2.
Drug Resistant Epilepsy
Multidrug resistance proteins in tuberous sclerosis and refractory epilepsy.
Drug Resistant Epilepsy
New proteins configure a brain drug resistance map in tuberous sclerosis.
Drug-Related Side Effects and Adverse Reactions
Genetics or environment in drug transport: the case of organic anion transporting polypeptides and adverse drug reactions.
Endometrial Neoplasms
Prognostic value of organic anion transporting polypeptide 1B3 and copper transporter 1 expression in endometrial cancer patients treated with paclitaxel and carboplatin.
Epilepsy
Drug transporters are altered in brain, liver and kidney of rats with chronic epilepsy induced by lithium-pilocarpine.
Epilepsy
Gene-wide tagging study of the association between ABCC2, ABCC5 and ABCG2 genetic polymorphisms and multidrug resistance in epilepsy.
Epilepsy
Lack of support for a role for RLIP76 (RALBP1) in response to treatment or predisposition to epilepsy.
Epilepsy
miR-23a-3p is involved in drug resistance by directly targeting the influx drug transporter organic anion-transporting polypeptide 2.
Epilepsy
Organic anion transporting polypeptide 2 transports valproic acid in rat brain microvascular endothelial cells.
Epilepsy
RLIP76 Gene Variants are not Associated with Drug Response in Turkish Epilepsy Patients.
Fatty Liver
Characterization of organic anion transporter regulation, glutathione metabolism and bile formation in the obese Zucker rat.
Glaucoma
ABCC5, a Gene That Influences the Anterior Chamber Depth, Is Associated with Primary Angle Closure Glaucoma.
Glaucoma
Correction: ABCC5, a Gene That Influences the Anterior Chamber Depth, Is Associated with Primary Angle Closure Glaucoma.
Glaucoma
The Association of Single Nucleotide Polymorphisms in ABCC5 Gene with Primary Angle Closure Glaucoma and the Ocular Biometric Parameters in a Northern Chinese Population.
Glaucoma, Angle-Closure
ABCC5, a Gene That Influences the Anterior Chamber Depth, Is Associated with Primary Angle Closure Glaucoma.
Glaucoma, Angle-Closure
Correction: ABCC5, a Gene That Influences the Anterior Chamber Depth, Is Associated with Primary Angle Closure Glaucoma.
Glaucoma, Angle-Closure
The Association of Single Nucleotide Polymorphisms in ABCC5 Gene with Primary Angle Closure Glaucoma and the Ocular Biometric Parameters in a Northern Chinese Population.
Glioblastoma
Increased RLIP76 expression in IDH1 wild?type glioblastoma multiforme is associated with worse prognosis.
Glioblastoma
Knockdown of RLIP76 expression by RNA interference inhibits invasion, induces cell cycle arrest, and increases chemosensitivity to the anticancer drug temozolomide in glioma cells.
Glioblastoma
P-glycoprotein and multidrug resistance-associated protein mediate specific patterns of multidrug resistance in malignant glioma cell lines, but not in primary glioma cells.
Glioblastoma
Prognostic significance of the immunohistochemical expression of O-methylguanine-DNA methyltransferase, P-glycoprotein, and multidrug resistance protein-1 in glioblastomas.
Glioblastoma
RLIP76 is overexpressed in human glioblastomas and is required for proliferation, tumorigenesis and suppression of apoptosis.
Glioma
ABCC drug efflux pumps and organic anion uptake transporters in human gliomas and the blood-tumor barrier.
Glioma
Knockdown of RLIP76 expression by RNA interference inhibits invasion, induces cell cycle arrest, and increases chemosensitivity to the anticancer drug temozolomide in glioma cells.
Glioma
MRP-1 protein expression and glutathione content of in vitro tumor cell lines derived from human glioma carcinoma U-87-MG do not interact with 99mTc-glucarate uptake.
Glioma
RLIP76 is overexpressed in human glioblastomas and is required for proliferation, tumorigenesis and suppression of apoptosis.
glucose-6-phosphate dehydrogenase (nadp+) deficiency
Genetic factors related to unconjugated hyperbilirubinemia amongst adults.
glucose-6-phosphate dehydrogenase (nadp+) deficiency
Molecular genetics of unconjugated hyperbilirubinemia in Taiwanese.
glucose-6-phosphate dehydrogenase (nadp+) deficiency
[Role of genetic factors in occurrence of neonatal jaundice in Guangxi region]
Glucosephosphate Dehydrogenase Deficiency
Genetic factors related to unconjugated hyperbilirubinemia amongst adults.
Glucosephosphate Dehydrogenase Deficiency
Molecular genetics of unconjugated hyperbilirubinemia in Taiwanese.
Hepatic Veno-Occlusive Disease
Correlation between Gd-EOB-DTPA-enhanced MR imaging findings and OATP1B3 expression in chemotherapy-associated sinusoidal obstruction syndrome.
Hepatitis B, Chronic
ABCC4, ABCC5 and SLC28A1 polymorphisms: host genome on responses of chronic hepatitis B patients with entecavir treatment.
Hepatitis C, Chronic
Expression of hepatic transporters OATP-C and MRP2 in primary sclerosing cholangitis.
Hepatoblastoma
Molecular and functional characterization of bile acid transport in human hepatoblastoma HepG2 cells.
Herpes Zoster
Molecular evidence of organic ion transporters in the rat adrenal cortex with adrenocorticotropin-regulated zonal expression.
Hyperbilirubinemia, Neonatal
Combined effects of the UGT1A1 and OATP2 gene polymorphisms as major risk factor for unconjugated hyperbilirubinemia in Indian neonates.
Hyperbilirubinemia, Neonatal
Molecular genetics of unconjugated hyperbilirubinemia in Taiwanese.
Hyperbilirubinemia, Neonatal
[Role of genetic factors in occurrence of neonatal jaundice in Guangxi region]
Hypoglycemia
RLIP76, a glutathione-conjugate transporter, plays a major role in the pathogenesis of metabolic syndrome.
Infections
An integrated in vitro model for simultaneous assessment of drug uptake, metabolism, and efflux.
Infections
Detection and characterisation of multi-drug resistance protein 1 (MRP-1) in human mitochondria.
Infections
Differential effects of p-glycoprotein and multidrug resistance protein-1 on productive human immunodeficiency virus infection.
Infections
Involvement of breast cancer resistance protein (BCRP/ABCG2) in the biliary excretion and intestinal efflux of troglitazone sulfate, the major metabolite of troglitazone with a cholestatic effect.
Infections
Repression of tick microRNA-133 induces organic anion transporting polypeptide expression critical for Anaplasma phagocytophilum survival in the vector and transmission to the vertebrate host.
Insulin Resistance
Abcc5 Knockout Mice Have Lower Fat Mass and Increased Levels of Circulating GLP-1.
Ischemic Stroke
Brain Delivery of a Potent Opioid Receptor Agonist, Biphalin during Ischemic Stroke: Role of Organic Anion Transporting Polypeptide (OATP).
Jaundice, Chronic Idiopathic
The function of the multidrug resistance proteins (MRP and cMRP) in drug conjugate transport and hepatobiliary excretion.
Jaundice, Neonatal
Gene Mutation in Neonatal Jaundice - Mutations in UGT1A1 and OATP2 Genes.
Kidney Neoplasms
Glutathione-conjugate transport by RLIP76 is required for clathrin-dependent endocytosis and chemical carcinogenesis.
Kidney Neoplasms
RLIP76 transports sunitinib and sorafenib and mediates drug resistance in kidney cancer.
Leukemia
Accelerated metabolism and exclusion of 4-hydroxynonenal through induction of RLIP76 and hGST5.8 is an early adaptive response of cells to heat and oxidative stress.
Leukemia
Downregulation of microRNA let-7f mediated the Adriamycin resistance in leukemia cell line.
Leukemia
High cellular accumulation of sulphoraphane, a dietary anticarcinogen, is followed by rapid transporter-mediated export as a glutathione conjugate.
Leukemia
Knockdown of HOXA10 reverses the multidrug resistance of human chronic mylogenous leukemia K562/ADM cells by downregulating P-gp and MRP-1.
Leukemia
Knockdown of RLIP76 expression by RNA interference inhibits proliferation, enhances apoptosis, and increases chemosensitivity to daunorubicin in U937 leukemia cells.
Leukemia
Synthesis of 2-aryl-4-(benzimidazol-2-yl)-1,2-dihydro[1,2,4]triazino-[4,5-a]benzimidazol-1-one derivatives with preferential cytotoxicity against carcinoma cell lines.
Leukemia
VX-710 (biricodar) increases drug retention and enhances chemosensitivity in resistant cells overexpressing P-glycoprotein, multidrug resistance protein, and breast cancer resistance protein.
Leukemia, Erythroblastic, Acute
Functional reconstitution of RLIP76 catalyzing ATP-dependent transport of glutathione-conjugates.
Leukemia, Myeloid, Acute
Application of flow cytometry immunophenotyping and multidrug resistance assay in B-cell acute lymphoid leukemia and multiple myeloma.
Leukemia, Myeloid, Acute
FLT3-ITD and MLL-PTD influence the expression of MDR-1, MRP-1, and BCRP mRNA but not LRP mRNA assessed with RQ-PCR method in adult acute myeloid leukemia.
Leukemia, Myeloid, Acute
P-glycoprotein and multidrug resistance associated protein-1 activity in 132 acute myeloid leukemias according to FAB subtypes and cytogenetics risk groups.
Leukemia, Myeloid, Acute
The 4'-O-benzylated doxorubicin analog WP744 overcomes resistance mediated by P-glycoprotein, multidrug resistance protein and breast cancer resistance protein in cell lines and acute myeloid leukemia cells.
Leukopenia
Effects of various genetic polymorphisms on thiopurine treatment-associated outcomes for Korean patients with Crohn's disease.
Liver Cirrhosis
Expression of hepatic transporters OATP-C and MRP2 in primary sclerosing cholangitis.
Liver Cirrhosis
Plasma concentrations of pemafibrate with co-administered drugs predicted by physiologically based pharmacokinetic modeling in virtual populations with renal/hepatic impairment.
Liver Cirrhosis, Biliary
Changes in the expression and localization of hepatocellular transporters and radixin in primary biliary cirrhosis.
Liver Cirrhosis, Biliary
Influence of biliary cirrhosis on the detoxification and elimination of a food derived carcinogen.
Liver Diseases
Expression of hepatic transporters OATP-C and MRP2 in primary sclerosing cholangitis.
Liver Diseases
Hepatocyte nuclear factor 1 alpha: a key mediator of the effect of bile acids on gene expression.
Liver Neoplasms
The analysis of organic anion transporting polypeptide (OATP) mRNA and protein patterns in primary and metastatic liver cancer.
Lung Neoplasms
ABCC5, ERCC2, XPA and XRCC1 transcript abundance levels correlate with cisplatin chemoresistance in non-small cell lung cancer cell lines.
Lung Neoplasms
Accelerated metabolism and exclusion of 4-hydroxynonenal through induction of RLIP76 and hGST5.8 is an early adaptive response of cells to heat and oxidative stress.
Lung Neoplasms
Emerging treatments in lung cancer - targeting the RLIP76 molecular transporter.
Lung Neoplasms
Folic acid (FA)-conjugated mesoporous silica nanoparticles combined with MRP-1 siRNA improves the suppressive effects of myricetin on non-small cell lung cancer (NSCLC).
Lung Neoplasms
High cytotoxic sensitivity of the human small cell lung doxorubicin-resistant carcinoma (GLC4/ADR) cell line to prodigiosin through apoptosis activation.
Lung Neoplasms
Increased expression and function of P-glycoprotein in peripheral blood CD56+ cells is associated with the chemoresistance of non-small-cell lung cancer.
Lung Neoplasms
MDR1/P-glycoprotein and MRP-1 mRNA and protein expression in non-small cell lung cancer.
Lung Neoplasms
Multidrug resistance markers P-glycoprotein, multidrug resistance protein 1, and lung resistance protein in non-small cell lung cancer: prognostic implications.
Lung Neoplasms
New insights into Vinca alkaloids resistance mechanism and circumvention in lung cancer.
Lung Neoplasms
Novel staging protocol for non-small-cell lung cancers according to MRP-1/CD9 and KAI1/CD82 gene expression.
Lung Neoplasms
Organic Anion Transporting Polypeptide 5A1 (OATP5A1) in Small Cell Lung Cancer (SCLC) Cells: Possible Involvement in Chemoresistance to Satraplatin.
Lung Neoplasms
RLIP76 transports vinorelbine and mediates drug resistance in non-small cell lung cancer.
Lung Neoplasms
Role of RLIP76 in lung cancer doxorubicin resistance: I. The ATPase activity of RLIP76 correlates with doxorubicin and 4-hydroxynonenal resistance in lung cancer cells.
Lung Neoplasms
Role of RLIP76 in lung cancer doxorubicin resistance: II. Doxorubicin transport in lung cancer by RLIP76.
Lung Neoplasms
Role of RLIP76 in lung cancer doxorubicin resistance: III. Anti-RLIP76 antibodies trigger apoptosis in lung cancer cells and synergistically increase doxorubicin cytotoxicity.
Lung Neoplasms
The determinants of sensitivity and acquired resistance to gemcitabine differ in non-small cell lung cancer: a role of ABCC5 in gemcitabine sensitivity.
Lung Neoplasms
The role of PKCalpha and RLIP76 in transport-mediated doxorubicin-resistance in lung cancer.
Lung Neoplasms
Unique expression features of cancer-type organic anion transporting polypeptide 1B3 mRNA expression in human colon and lung cancers.
Lung Neoplasms
[Expression of KAI1, MRP-1, and FAK proteins in lung cancer detected by high-density tissue microarray]
Lung Neoplasms
[Role and clinical significance of RLIP76 in regulation of multi-drug resistance of small cell lung cancer].
Lung Neoplasms
[Substantiation of Expressive Markers Use to Personalize Lung Cancer Chemotherapy].
Lupus Erythematosus, Systemic
P-glycoprotein-1 functional activity in CD5+CD7+ and CD20+ lymphocytes in systemic lupus erythematosus children: relation to disease activity, complications and steroid response.
Lymphatic Metastasis
A study on the correlations of MRP-1 expression with the pathogenesis and prognosis of colorectal cancer.
Lymphatic Metastasis
Expression levels of insulin-like growth factor-1 and multidrug resistance-associated protein-1 indicate poor prognosis in patients with gastric cancer.
Lymphatic Metastasis
Upregulation of autophagy-related gene-5 (ATG-5) is associated with chemoresistance in human gastric cancer.
Lymphatic Metastasis
[Expression of KAI1, MRP-1, and FAK proteins in lung cancer detected by high-density tissue microarray]
Lymphoma
A longitudinal study of ABC transporter expression in canine multicentric lymphoma.
Lymphoma
Immunohistochemical expression of multidrug resistance proteins in mature T/NK-cell lymphomas.
Lymphoma, T-Cell
A longitudinal study of ABC transporter expression in canine multicentric lymphoma.
Malformations of Cortical Development
Multidrug-resistance protein 1 in focal cortical dysplasia.
Melanoma
Membrane transport proteins in human melanoma: associations with tumour aggressiveness and metastasis.
Melanoma
RLIP76 regulates HIF-1 activity, VEGF expression and secretion in tumor cells, and secretome transactivation of endothelial cells.
Melanoma
RLIP76 silencing inhibits cell proliferation and invasion in melanoma cell line A375.
Melanoma
Suppression of cell motility and metastasis by transfection with human motility-related protein (MRP-1/CD9) DNA.
Melanoma
The non-ABC drug transporter RLIP76 (RALBP-1) plays a major role in the mechanisms of drug resistance.
Melanoma
Upregulation of miR-124 by physcion 8-O-?-glucopyranoside inhibits proliferation and invasion of malignant melanoma cells via repressing RLIP76.
Meningioma
Overexpression of RLIP76 Required for Proliferation in Meningioma Is Associated with Recurrence.
Metabolic Syndrome
RLIP76, a glutathione-conjugate transporter, plays a major role in the pathogenesis of metabolic syndrome.
Microphthalmos
Lens specific RLIP76 transgenic mice show a phenotype similar to microphthalmia.
Muscular Diseases
Experimental nonalcoholic steatohepatitis increases exposure to simvastatin hydroxy acid by decreasing hepatic organic anion transporting polypeptide expression.
Muscular Diseases
Functional analysis of a mutation in the SLCO1B1 gene (c.1628T>G) identified in a Japanese patient with pravastatin-induced myopathy.
Muscular Diseases
Role of multi-drug resistance-associated protein-1 transporter in statin-induced myopathy.
Neoplasm Metastasis
A study on the correlations of MRP-1 expression with the pathogenesis and prognosis of colorectal cancer.
Neoplasm Metastasis
ABCC5 supports osteoclast formation and promotes breast cancer metastasis to bone.
Neoplasm Metastasis
Correlation between Gd-EOB-DTPA-enhanced MR imaging findings and OATP1B3 expression in chemotherapy-associated sinusoidal obstruction syndrome.
Neoplasm Metastasis
Expression levels of insulin-like growth factor-1 and multidrug resistance-associated protein-1 indicate poor prognosis in patients with gastric cancer.
Neoplasm Metastasis
Loss of miR-516a-3p mediates upregulation of ABCC5 in prostate cancer and drives its progression.
Neoplasm Metastasis
Membrane transport proteins in human melanoma: associations with tumour aggressiveness and metastasis.
Neoplasm Metastasis
Suppression of cell motility and metastasis by transfection with human motility-related protein (MRP-1/CD9) DNA.
Neoplasm Metastasis
The structure of the RLIP76 RhoGAP-Ral binding domain dyad: fixed position of the domains leads to dual engagement of small G proteins at the membrane.
Neoplasm Metastasis
Upregulation of autophagy-related gene-5 (ATG-5) is associated with chemoresistance in human gastric cancer.
Neoplasm Metastasis
Zoledronic acid is synergic with vinblastine to induce apoptosis in a multidrug resistance protein-1 dependent way: An in vitro study.
Neoplasm Metastasis
[Expression of drug resistance and metastasis related gene in adenoid cystic carcinoma and mucoepidermoid carcinoma]
Neoplasm Metastasis
[Expression of KAI1, MRP-1, and FAK proteins in lung cancer detected by high-density tissue microarray]
Neoplasms
2'-Hydroxyflavanone inhibits in vitro and in vivo growth of breast cancer cells by targeting RLIP76.
Neoplasms
A longitudinal study of ABC transporter expression in canine multicentric lymphoma.
Neoplasms
A novel class of tubulin inhibitors that exhibit potent antiproliferation and in vitro vessel-disrupting activity.
Neoplasms
ABCC drug efflux pumps and organic anion uptake transporters in human gliomas and the blood-tumor barrier.
Neoplasms
Alteration of Bile Acid and Cholesterol Biosynthesis and Transport by Perfluorononanoic Acid (PFNA) in Mice.
Neoplasms
Cancer-type organic anion transporting polypeptide 1B3 is a target for cancer suicide gene therapy using RNA trans-splicing technology.
Neoplasms
Clinicopathological parameters and expression of P-glycoprotein and MRP-1 in retinoblastoma.
Neoplasms
Co-administration of probenecid, an inhibitor of a cMOAT/MRP-like plasma membrane ATPase, greatly enhanced the efficacy of a new 10-deazaaminopterin against human solid tumors in vivo.
Neoplasms
Detection and characterisation of multi-drug resistance protein 1 (MRP-1) in human mitochondria.
Neoplasms
Development and characterization of five cell models for chemoresistance studies of human ovarian carcinoma.
Neoplasms
Differences in Transcript Levels of ABC Transporters Between Pancreatic Adenocarcinoma and Nonneoplastic Tissues.
Neoplasms
DNA methylation profiles of organic anion transporting polypeptide 1B3 in cancer cell lines.
Neoplasms
Downregulation of RLIP76 is associated with vincristine resistance in human colorectal cancer HCT-8/VCR cells.
Neoplasms
Effect of Stemona curtisii root extract on P-glycoprotein and MRP-1 function in multidrug-resistant cancer cells.
Neoplasms
Epigenetic Regulation of Organic Anion Transporting Polypeptide 1B3 in Cancer Cell Lines.
Neoplasms
Evaluation of the Effects of Repeat-Dose Dabrafenib on the Single-Dose Pharmacokinetics of Rosuvastatin (OATP1B1/1B3 Substrate) and Midazolam (CYP3A4 Substrate).
Neoplasms
Exploring cysteine regulation in cancer cell survival with a highly specific "Lock and Key" fluorescent probe for cysteine.
Neoplasms
Expression levels of insulin-like growth factor-1 and multidrug resistance-associated protein-1 indicate poor prognosis in patients with gastric cancer.
Neoplasms
Expression of multidrug resistance markers ABCB1 (MDR-1/P-gp) and ABCC1 (MRP-1) in renal cell carcinoma.
Neoplasms
Expression of multidrug resistance-related protein (mrp-1), lung resistance-related protein (lrp) and topoisomerase-ii (topo-ii) in wilms' tumor: immunohistochemical study using tma methodology.
Neoplasms
Folic acid (FA)-conjugated mesoporous silica nanoparticles combined with MRP-1 siRNA improves the suppressive effects of myricetin on non-small cell lung cancer (NSCLC).
Neoplasms
Genetic Polymorphisms Associated to Folate Transport as Predictors of Increased Risk for Acute Lymphoblastic Leukemia in Mexican Children.
Neoplasms
Glutathione-conjugate transport by RLIP76 is required for clathrin-dependent endocytosis and chemical carcinogenesis.
Neoplasms
Haploinsufficiency Interactions between RALBP1 and p53 in ERBB2 and PyVT Models of Mouse Mammary Carcinogenesis.
Neoplasms
Hepatocellular carcinoma: hepatocyte-selective enhancement at gadoxetic acid-enhanced MR imaging--correlation with expression of sinusoidal and canalicular transporters and bile accumulation.
Neoplasms
High pretherapeutic thymidylate synthetase and MRP-1 protein levels are associated with nonresponse to neoadjuvant chemotherapy in oesophageal adenocarcinoma patients.
Neoplasms
Human drug efflux transporter ABCC5 confers acquired resistance to pemetrexed in breast cancer.
Neoplasms
Identification of GAS1 as an epirubicin resistance-related gene in human gastric cancer cells with a partially randomized small interfering RNA library.
Neoplasms
Immunohistochemical expression of multidrug resistance proteins in mature T/NK-cell lymphomas.
Neoplasms
Increased anti-tumour efficacy of doxorubicin when combined with sulindac in a xenograft model of an MRP-1-positive human lung cancer.
Neoplasms
Increased expression of cdc2 inhibits transport function of RLIP76 and promotes apoptosis.
Neoplasms
Inflammation Modulates RLIP76/RALBP1 Electrophile-Glutathione Conjugate Transporter and Housekeeping Genes in Human Blood-Brain Barrier Endothelial Cells.
Neoplasms
Inhibition of mercapturic acid pathway-mediated disposal of 4-hydroxynonenal causes complete and sustained remission of human cancer xenografts in nude mice.
Neoplasms
Investigation of MRP-1 protein and MDR-1 P-glycoprotein expression in invasive breast cancer: a prognostic study.
Neoplasms
Involvement of miR-326 in chemotherapy resistance of breast cancer through modulating expression of multidrug resistance-associated protein 1.
Neoplasms
Kaempferol enhances cisplatin's effect on ovarian cancer cells through promoting apoptosis caused by down regulation of cMyc.
Neoplasms
Knockdown of RLIP76 expression by RNA interference inhibits invasion, induces cell cycle arrest, and increases chemosensitivity to the anticancer drug temozolomide in glioma cells.
Neoplasms
Knockdown of RLIP76 expression by RNA interference inhibits proliferation, enhances apoptosis, and increases chemosensitivity to daunorubicin in U937 leukemia cells.
Neoplasms
Lack of prognostic significance of survivin, survivin-deltaEx3, survivin-2B, galectin-3, bag-1, bax-alpha and MRP-1 mRNAs in breast cancer.
Neoplasms
Linking stress-signaling, glutathione metabolism, signaling pathways and xenobiotic transporters.
Neoplasms
Lipopolysaccharide-induced down-regulation of organic anion transporting polypeptide 4 (Oatp4; Slc21a10) is independent of tumor necrosis factor-alpha, Interleukin-1beta, interleukin-6, or inducible nitric oxide synthase.
Neoplasms
Loss of miR-516a-3p mediates upregulation of ABCC5 in prostate cancer and drives its progression.
Neoplasms
Maternal western-style diet enhances the effects of chemically-induced mammary tumors in female rat offspring through transcriptome changes.
Neoplasms
MDR1/P-glycoprotein and MRP-1 mRNA and protein expression in non-small cell lung cancer.
Neoplasms
Membrane transport proteins in human melanoma: associations with tumour aggressiveness and metastasis.
Neoplasms
miR-340 suppresses tumor growth and enhances chemosensitivity of colorectal cancer by targeting RLIP76.
Neoplasms
MPC-6827: a small-molecule inhibitor of microtubule formation that is not a substrate for multidrug resistance pumps.
Neoplasms
MRP-1 protein expression and glutathione content of in vitro tumor cell lines derived from human glioma carcinoma U-87-MG do not interact with 99mTc-glucarate uptake.
Neoplasms
Multidrug resistance markers P-glycoprotein, multidrug resistance protein 1, and lung resistance protein in non-small cell lung cancer: prognostic implications.
Neoplasms
Multidrug resistance modulators PSC 833 and CsA show differential capacity to induce apoptosis in lymphoid leukemia cell lines independently of their MDR phenotype.
Neoplasms
Nilotinib counteracts P-glycoprotein-mediated multidrug resistance and synergizes the antitumoral effect of doxorubicin in soft tissue sarcomas.
Neoplasms
Novel staging protocol for non-small-cell lung cancers according to MRP-1/CD9 and KAI1/CD82 gene expression.
Neoplasms
Overexpression of RLIP76 Required for Proliferation in Meningioma Is Associated with Recurrence.
Neoplasms
P-glycoprotein and multidrug resistance-associated protein mediate specific patterns of multidrug resistance in malignant glioma cell lines, but not in primary glioma cells.
Neoplasms
Phytochemical Inhibition of Multidrug Resistance Protein-1 as a Therapeutic Strategy for Hemangioendothelioma.
Neoplasms
POB1 over-expression inhibits RLIP76-mediated transport of glutathione-conjugates, drugs and promotes apoptosis.
Neoplasms
Preliminary individual adjuvant chemotherapy for primary central nervous system lymphomas based on the expression of drug-resistance genes.
Neoplasms
Prognostic significance of the immunohistochemical expression of O-methylguanine-DNA methyltransferase, P-glycoprotein, and multidrug resistance protein-1 in glioblastomas.
Neoplasms
Quantitative evaluation of ABC transporter-mediated drug resistance based on the determination of the anticancer activity of camptothecin against breast cancer stem cells using TIRF.
Neoplasms
RALBP1/RLIP76 depletion in mice suppresses tumor growth by inhibiting tumor neovascularization.
Neoplasms
Rapid modulation of the organic anion transporting polypeptide 2B1 (OATP2B1, SLCO2B1) function by protein kinase C-mediated internalization.
Neoplasms
RLIP76 (RALBP1)-mediated transport of leukotriene C4 (LTC4) in cancer cells: implications in drug resistance.
Neoplasms
RLIP76 blockade by siRNA inhibits proliferation, enhances apoptosis, and suppresses invasion in HT29 colon cancer cells.
Neoplasms
RLIP76 is overexpressed in human glioblastomas and is required for proliferation, tumorigenesis and suppression of apoptosis.
Neoplasms
RLIP76 regulates HIF-1 activity, VEGF expression and secretion in tumor cells, and secretome transactivation of endothelial cells.
Neoplasms
RLIP76 silencing inhibits cell proliferation and invasion in melanoma cell line A375.
Neoplasms
RLIP76 transports sunitinib and sorafenib and mediates drug resistance in kidney cancer.
Neoplasms
Role of RLIP76 in lung cancer doxorubicin resistance: I. The ATPase activity of RLIP76 correlates with doxorubicin and 4-hydroxynonenal resistance in lung cancer cells.
Neoplasms
Role of RLIP76 in lung cancer doxorubicin resistance: II. Doxorubicin transport in lung cancer by RLIP76.
Neoplasms
Role of RLIP76 in lung cancer doxorubicin resistance: III. Anti-RLIP76 antibodies trigger apoptosis in lung cancer cells and synergistically increase doxorubicin cytotoxicity.
Neoplasms
Structure-activity relationship of indomethacin analogues for MRP-1, COX-1 and COX-2 inhibition. identification of novel chemotherapeutic drug resistance modulators.
Neoplasms
Targeting an extracellular epitope of the human multidrug resistance protein 1 (MRP1) in malignant cells with a novel recombinant single chain Fv antibody.
Neoplasms
The 4'-O-benzylated doxorubicin analog WP744 overcomes resistance mediated by P-glycoprotein, multidrug resistance protein and breast cancer resistance protein in cell lines and acute myeloid leukemia cells.
Neoplasms
The anticancer agent prodigiosin is not a multidrug resistance protein substrate.
Neoplasms
The FOXM1-ABCC5 axis contributes to paclitaxel resistance in nasopharyngeal carcinoma cells.
Neoplasms
The non-ABC drug transporter RLIP76 (RALBP-1) plays a major role in the mechanisms of drug resistance.
Neoplasms
The proteins FABP7 and OATP2 are associated with the basal phenotype and patient outcome in human breast cancer.
Neoplasms
The RLIP76 N-terminus binds ARNO to regulate PI 3-kinase, Arf6 and Rac signaling, cell spreading and migration.
Neoplasms
Tumor suppressor gene Runx3 sensitizes gastric cancer cells to chemotherapeutic drugs by downregulating Bcl-2, MDR-1 and MRP-1.
Neoplasms
Upregulation of autophagy-related gene-5 (ATG-5) is associated with chemoresistance in human gastric cancer.
Neoplasms
Varied clinical significance of ATP-binding cassette C sub-family members for lung adenocarcinoma.
Neoplasms
VX-710 (biricodar) increases drug retention and enhances chemosensitivity in resistant cells overexpressing P-glycoprotein, multidrug resistance protein, and breast cancer resistance protein.
Neoplasms
[Correlation of metastasis-free survival in patients with breast cancer and changes in the direction of expression of multidrug resistance genes during neoadjuvant chemotherapy].
Neoplasms
[Expression of KAI1, MRP-1, and FAK proteins in lung cancer detected by high-density tissue microarray]
Nephrotic Syndrome
Overexpression of P-glycoprotein and MRP-1 are pharmacogenomic biomarkers to determine steroid resistant phenotype in childhood idiopathic nephrotic syndrome.
Nervous System Diseases
Multidrug resistance-associated proteins: expression and function in the central nervous system.
Neuroblastoma
DNA (cytosine) methyltransferase overexpression is associated with acquired drug resistance of murine neuroblastoma cells.
Neuroblastoma
NDRG1 promotes the multidrug resistance of neuroblastoma cells with upregulated expression of drug resistant proteins.
Neuroblastoma
SNHG16 promotes tumorigenesis and cisplatin resistance by regulating miR-338-3p/PLK4 pathway in neuroblastoma cells.
Neuroblastoma
[131I]MIBG exports via MRP transporters and inhibition of the MRP transporters improves accumulation of [131I]MIBG in neuroblastoma.
Neuroectodermal Tumors
Expression and functional activity of the ABC-transporter proteins P-glycoprotein and multidrug-resistance protein 1 in human brain tumor cells and astrocytes.
Non-alcoholic Fatty Liver Disease
Experimental nonalcoholic steatohepatitis increases exposure to simvastatin hydroxy acid by decreasing hepatic organic anion transporting polypeptide expression.
Non-alcoholic Fatty Liver Disease
Pharmacokinetic herb-disease-drug interactions: Effect of ginkgo biloba extract on the pharmacokinetics of pitavastatin, a substrate of Oatp1b2, in rats with non-alcoholic fatty liver disease.
Non-alcoholic Fatty Liver Disease
Transporter Activity Changes in Nonalcoholic Steatohepatitis: Assessment with Plasma Coproporphyrin I and III.
Obesity
Inhibition of Hepatic Bile Acid Uptake by Myrcludex B Promotes Glucagon-Like Peptide-1 Release and Reduces Obesity.
Obesity
The inhibition of hepatic Pxr-Oatp2 pathway mediating decreased hepatic uptake of rosuvastatin in rats with high-fat diet-induced obesity.
Oligodendroglioma
ABCC drug efflux pumps and organic anion uptake transporters in human gliomas and the blood-tumor barrier.
Osteoporosis
Zoledronic acid is synergic with vinblastine to induce apoptosis in a multidrug resistance protein-1 dependent way: An in vitro study.
Osteosarcoma
Circular RNA circ-CHI3L1.2 modulates cisplatin resistance of osteosarcoma cells via the miR-340-5p/LPAAT? axis.
Osteosarcoma
Variants of FasL and ABCC5 are predictive of outcome after chemotherapy-based treatment in osteosarcoma.
Ovarian Neoplasms
Clinical Significance of Organic Anion Transporting Polypeptide Gene Expression in High-Grade Serous Ovarian Cancer.
Ovarian Neoplasms
Decreased LRIG1 in Human Ovarian Cancer Cell SKOV3 Upregulates MRP-1 and Contributes to the Chemoresistance of VP16.
Pancreatic Neoplasms
A cancer-specific variant of the SLCO1B3 gene encodes a novel human organic anion transporting polypeptide 1B3 (OATP1B3) localized mainly in the cytoplasm of colon and pancreatic cancer cells.
Pancreatic Neoplasms
microRNA-210 overexpression inhibits tumor growth and potentially reverses gemcitabine resistance in pancreatic cancer.
Pancreatic Neoplasms
RLIP76 regulates PI3K/Akt signaling and chemo-radiotherapy resistance in pancreatic cancer.
Pancreatic Neoplasms
Role of hypoxia inducible factor-1? in the regulation of the cancer-specific variant of organic anion transporting polypeptide 1B3 (OATP1B3), in colon and pancreatic cancer.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Polymorphisms of ABCC5 and NOS3 genes influence doxorubicin cardiotoxicity in survivors of childhood acute lymphoblastic leukemia.
Prostatic Neoplasms
Expression of OATP family members in hormone-related cancers: potential markers of progression.
Prostatic Neoplasms
Loss of miR-516a-3p mediates upregulation of ABCC5 in prostate cancer and drives its progression.
Prostatic Neoplasms
RLIP76-dependent suppression of PI3K/AKT/Bcl-2 pathway by miR-101 induces apoptosis in prostate cancer.
Prostatic Neoplasms
RLIP76: a versatile transporter and an emerging target for cancer therapy.
Prostatic Neoplasms
Role of OATP transporters in steroid uptake by prostate cancer cells in vivo.
Prostatic Neoplasms
Upregulation of ATP Binding Cassette Subfamily C Member 5 facilitates Prostate Cancer progression and Enzalutamide resistance via the CDK1-mediated AR Ser81 Phosphorylation Pathway.
Renal Insufficiency
6-Hydroxyindole is an endogenous long-lasting OATP1B1 inhibitor elevated in renal failure patients.
Renal Insufficiency
Recovery of OATP1B Activity after Living Kidney Transplantation in Patients with End-Stage Renal Disease.
Renal Insufficiency, Chronic
Simultaneous quantification of coproporphyrin-I and 3-carboxy-4-methyl-5-propyl-2-furanpropanoic acid in human plasma using ultra-high performance liquid chromatography coupled to tandem mass spectrometry.
Renal Insufficiency, Chronic
Transcriptional regulation of organic anion transporting polypeptide SLCO4C1 as a new therapeutic modality to prevent chronic kidney disease.
Retinoblastoma
Clinicopathological parameters and expression of P-glycoprotein and MRP-1 in retinoblastoma.
Rhabdomyosarcoma
Expression of multidrug resistance-associated proteins in rhabdomyosarcomas before and after chemotherapy: the relationship between lung resistance-related protein (LRP) and differentiation.
Sarcoma
Oleanolic and maslinic acid sensitize soft tissue sarcoma cells to doxorubicin by inhibiting the multidrug resistance protein MRP-1, but not P-glycoprotein.
Sarcoma, Synovial
Nilotinib counteracts P-glycoprotein-mediated multidrug resistance and synergizes the antitumoral effect of doxorubicin in soft tissue sarcomas.
Seizures
Drug transporters are altered in brain, liver and kidney of rats with chronic epilepsy induced by lithium-pilocarpine.
Seizures
miR-23a-3p is involved in drug resistance by directly targeting the influx drug transporter organic anion-transporting polypeptide 2.
Seizures
Organic anion transporting polypeptide 2 transports valproic acid in rat brain microvascular endothelial cells.
Small Cell Lung Carcinoma
Organic Anion Transporting Polypeptide 5A1 (OATP5A1) in Small Cell Lung Cancer (SCLC) Cells: Possible Involvement in Chemoresistance to Satraplatin.
Small Cell Lung Carcinoma
The role of PKCalpha and RLIP76 in transport-mediated doxorubicin-resistance in lung cancer.
Small Cell Lung Carcinoma
[Expression of KAI1, MRP-1, and FAK proteins in lung cancer detected by high-density tissue microarray]
Small Cell Lung Carcinoma
[Role and clinical significance of RLIP76 in regulation of multi-drug resistance of small cell lung cancer].
Stomach Neoplasms
CIAPIN1 Confers Multidrug Resistance by Upregulating the Expression of MDR-1 and MRP-1 in Gastric Cancer Cells.
Stomach Neoplasms
Docetaxel enhances the cytotoxicity of cisplatin to gastric cancer cells by modification of intracellular platinum metabolism.
Stomach Neoplasms
RLIP76 increases apoptosis through Akt/mTOR signaling pathway in gastric cancer.
Stomach Neoplasms
Tumor suppressor gene Runx3 sensitizes gastric cancer cells to chemotherapeutic drugs by downregulating Bcl-2, MDR-1 and MRP-1.
Stomach Neoplasms
[Corrigendum] RLIP76 increases apoptosis through Akt/mTOR signaling pathway in gastric cancer.
Stroke
Differential regulation of transport proteins in the periinfarct region following reversible middle cerebral artery occlusion in rats.
Tuberous Sclerosis
Multidrug resistance proteins in tuberous sclerosis and refractory epilepsy.
Tuberous Sclerosis
New proteins configure a brain drug resistance map in tuberous sclerosis.
Urolithiasis
MRP-1 and BCRP Promote the Externalization of Phosphatidylserine in Oxalate-treated Renal Epithelial Cells: Implications for Calcium Oxalate Urolithiasis.
Uterine Cervical Neoplasms
Increased Gene Expression of the ABCC5 Transporter without Distinct Changes in the Expression of PDE5 in Human Cervical Cancer Cells during Growth.
Vaccinia
OATP and P-glycoprotein transporters mediate the cellular uptake and excretion of fexofenadine.
Vaccinia
Uptake of enalapril and expression of organic anion transporting polypeptide 1 in zonal, isolated rat hepatocytes.
Vascular Diseases
Autoantibodies to the C-terminal subunit of RLIP76 induce oxidative stress and endothelial cell apoptosis in immune-mediated vascular diseases and atherosclerosis.
Vascular Diseases
Gender Disparity in Susceptibility to Oxidative Stress and Apoptosis Induced by Autoantibodies Specific to RLIP76 in Vascular Cells.
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ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
SOURCE
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GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
physiological function
the enzyme plays a major role in the hepatic biliary and basolateral excretion of sulfate, glucuronide, and glutathione metabolites
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UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable).
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable). Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Zamek-Gliszczynski, M.; Hoffmaster, K.; Nezasa, K.; Tallman, M.; Brouwer, K.
Integration of hepatic drug transporters and phase II metabolizing enzymes Mechanisms of hepatic excretion of sulfate, glucuronide, and glutathione metabolites
Eur. J. Pharm. Sci.
27
447-486
2006
Mus musculus, Mus musculus (P04095), Mus musculus (Q7TMS5), Mus musculus (Q8VI47), Homo sapiens (O15438), Homo sapiens (O15439), Homo sapiens (Q92887), Homo sapiens (Q9UNQ0), Rattus norvegicus (Q63120), Rattus norvegicus (Q6QMG6), Rattus norvegicus (Q80W57), Rattus norvegicus (Q88563)
brenda
EXTERNAL LINKS (specific for EC-Number 7.6.2.3)
Transporter Classification Database (TCDB): 9.A.1.1.1, 3.A.1.208.3, 3.A.1.208.8, 3.A.1.208.2, 3.A.1.208.11, 3.A.1.208.9, 3.A.1.208.7, 3.A.1.208.10, 3.A.1.208.1, 3.A.1.208.31, 3.A.1.208.13
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Release 2023.1 (January 2023)
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