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ATP binding cassette putrescine-specific uptake system
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ATP-binding cassette putrescine-specific uptake system
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ATP-dependent putrescine transporter
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dependent putrescine transporter
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PotF
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putrescine-binding protein subunit
PotG
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membrane-associated ATPase subunit
PotH
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channel-forming protein subunit
PotI
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channel-forming protein subunit
PUT-specific uptake system
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putrescine ABC transporter
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putrescine transport system
putrescine transporting ATPase
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putrescine-specific uptake system
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consists of PotF (the substrate binding protein), PotG (an ATPase), and PotH and PotI (channel-forming transmembrane proteins)
potFGHI
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putrescine transport system
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putrescine transport system
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ATP + H2O + putrescine-[putrescine-binding protein PotF][side 1]
ADP + phosphate + putrescine[side 2] + [putrescine-binding protein PotF][side 1]
ATP + H2O + putrescine-[putrescine-binding protein][side 1]
ADP + phosphate + putrescine[side 2] + [putrescine-binding protein][side 1]
ATP + H2O + spermidine-[spermidine-binding protein][side 1]
ADP + phosphate + spermidine[side 2] + [spermidine-binding protein][side 1]
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?
additional information
?
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ATP + H2O + putrescine-[putrescine-binding protein PotF][side 1]
ADP + phosphate + putrescine[side 2] + [putrescine-binding protein PotF][side 1]
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?
ATP + H2O + putrescine-[putrescine-binding protein PotF][side 1]
ADP + phosphate + putrescine[side 2] + [putrescine-binding protein PotF][side 1]
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?
ATP + H2O + putrescine-[putrescine-binding protein][side 1]
ADP + phosphate + putrescine[side 2] + [putrescine-binding protein][side 1]
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?
ATP + H2O + putrescine-[putrescine-binding protein][side 1]
ADP + phosphate + putrescine[side 2] + [putrescine-binding protein][side 1]
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?
ATP + H2O + putrescine-[putrescine-binding protein][side 1]
ADP + phosphate + putrescine[side 2] + [putrescine-binding protein][side 1]
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?
ATP + H2O + putrescine-[putrescine-binding protein][side 1]
ADP + phosphate + putrescine[side 2] + [putrescine-binding protein][side 1]
the enzyme shows a marked preference for putrescine over spermidine
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?
additional information
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no binding activity to cadaverine and spermine
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?
additional information
?
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no binding activity to cadaverine and spermine
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?
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ATP + H2O + putrescine-[putrescine-binding protein PotF][side 1]
ADP + phosphate + putrescine[side 2] + [putrescine-binding protein PotF][side 1]
ATP + H2O + putrescine-[putrescine-binding protein][side 1]
ADP + phosphate + putrescine[side 2] + [putrescine-binding protein][side 1]
ATP + H2O + spermidine-[spermidine-binding protein][side 1]
ADP + phosphate + spermidine[side 2] + [spermidine-binding protein][side 1]
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?
ATP + H2O + putrescine-[putrescine-binding protein PotF][side 1]
ADP + phosphate + putrescine[side 2] + [putrescine-binding protein PotF][side 1]
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?
ATP + H2O + putrescine-[putrescine-binding protein PotF][side 1]
ADP + phosphate + putrescine[side 2] + [putrescine-binding protein PotF][side 1]
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?
ATP + H2O + putrescine-[putrescine-binding protein][side 1]
ADP + phosphate + putrescine[side 2] + [putrescine-binding protein][side 1]
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?
ATP + H2O + putrescine-[putrescine-binding protein][side 1]
ADP + phosphate + putrescine[side 2] + [putrescine-binding protein][side 1]
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?
ATP + H2O + putrescine-[putrescine-binding protein][side 1]
ADP + phosphate + putrescine[side 2] + [putrescine-binding protein][side 1]
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?
ATP + H2O + putrescine-[putrescine-binding protein][side 1]
ADP + phosphate + putrescine[side 2] + [putrescine-binding protein][side 1]
the enzyme shows a marked preference for putrescine over spermidine
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-
?
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abc-type putrescine transporter deficiency
Dermal Fibroblast SLC3A2 Deficiency Leads to Premature Aging and Loss of Epithelial Homeostasis.
Adenocarcinoma of Lung
Targeting SLC3A2 subunit of system XC- is essential for m6A reader YTHDC2 to be an endogenous ferroptosis inducer in lung adenocarcinoma.
Asthma
TMT-based quantitative proteomics reveals suppression of SLC3A2 and ATP1A3 expression contributes to the inhibitory role of acupuncture on airway inflammation in an OVA-induced mouse asthma model.
Breast Neoplasms
xCT-Driven Expression of GPX4 Determines Sensitivity of Breast Cancer Cells to Ferroptosis Inducers.
Carcinoma
SLC3A2, antigen of mAb 3G9, promotes migration and invasion by upregulating of mucins in gastric cancer.
Carcinoma
SLC3A2/CD98hc, autophagy and tumor radioresistance: a link confirmed.
Carcinoma
The CD98 heavy chain is a marker and regulator of head and neck squamous cell carcinoma radiosensitivity.
Carcinoma, Hepatocellular
IFN?-mediated repression of system xc- drives vulnerability to induced ferroptosis in hepatocellular carcinoma cells.
Carcinoma, Hepatocellular
Loss of intracellular putrescine pool-size regulation induces apoptosis.
Carcinoma, Squamous Cell
SLC3A2/CD98hc, autophagy and tumor radioresistance: a link confirmed.
Carcinoma, Squamous Cell
The CD98 heavy chain is a marker and regulator of head and neck squamous cell carcinoma radiosensitivity.
Colonic Neoplasms
Identification and characterization of a diamine exporter in colon epithelial cells.
Infections
Feature Article: Evidence for additive and interaction effects of host genotype and infection in malaria.
Lung Neoplasms
The receptor protein tyrosine phosphatase PTPRJ negatively modulates the CD98hc oncoprotein in lung cancer cells.
Mouth Neoplasms
Overexpression of membranal SLC3A2 regulates the proliferation of oral squamous cancer cells and affects the prognosis of oral cancer patients.
Neoplasms
18F-Fluciclovine PET metabolic imaging reveals prostate cancer tumour heterogeneity associated with disease resistance to androgen deprivation therapy.
Neoplasms
CD8+ T cells regulate tumour ferroptosis during cancer immunotherapy.
Neoplasms
Discovery of SLC3A2 cell membrane protein as a potential gastric cancer biomarker: implications in molecular imaging.
Neoplasms
HPV status, cancer stem cell marker expression, hypoxia gene signatures and tumour volume identify good prognosis subgroups in patients with HNSCC after primary radiochemotherapy: A multicentre retrospective study of the German Cancer Consortium Radiation Oncology Group (DKTK-ROG).
Neoplasms
Immunotherapy using IgE or CAR T cells for cancers expressing the tumor antigen SLC3A2.
Neoplasms
Low Cancer Stem Cell Marker Expression and Low Hypoxia Identify Good Prognosis Subgroups in HPV(-) HNSCC after Postoperative Radiochemotherapy: A Multicenter Study of the DKTK-ROG.
Neoplasms
Overexpression of membranal SLC3A2 regulates the proliferation of oral squamous cancer cells and affects the prognosis of oral cancer patients.
Neoplasms
SLC3A2 is upregulated in human osteosarcoma and promotes tumor growth through the PI3K/Akt signaling pathway.
Neoplasms
SLC3A2, antigen of mAb 3G9, promotes migration and invasion by upregulating of mucins in gastric cancer.
Neoplasms
SLC3A2/CD98hc, autophagy and tumor radioresistance: a link confirmed.
Neoplasms
Targeting SLC3A2 subunit of system XC- is essential for m6A reader YTHDC2 to be an endogenous ferroptosis inducer in lung adenocarcinoma.
Neoplasms
The multifunctional solute carrier 3A2 (SLC3A2) confers a poor prognosis in the highly proliferative breast cancer subtypes.
Neoplasms
ZEB1 Promotes Chemoresistance to Cisplatin in Ovarian Cancer Cells by Suppressing SLC3A2.
Neuroblastoma
Functional induction of the cystine-glutamate exchanger system Xc(-) activity in SH-SY5Y cells by unconjugated bilirubin.
Neuroblastoma
Inhibition of polyamine synthesis and uptake reduces tumor progression and prolongs survival in mouse models of neuroblastoma.
Osteosarcoma
SLC3A2 is upregulated in human osteosarcoma and promotes tumor growth through the PI3K/Akt signaling pathway.
Ovarian Neoplasms
ZEB1 Promotes Chemoresistance to Cisplatin in Ovarian Cancer Cells by Suppressing SLC3A2.
Prostatic Neoplasms
Ferroptosis Inducers Are a Novel Therapeutic Approach for Advanced Prostate Cancer.
Squamous Cell Carcinoma of Head and Neck
Independent validation of the prognostic value of cancer stem cell marker expression and hypoxia-induced gene expression for patients with locally advanced HNSCC after postoperative radiotherapy.
Squamous Cell Carcinoma of Head and Neck
SLC3A2/CD98hc, autophagy and tumor radioresistance: a link confirmed.
Squamous Cell Carcinoma of Head and Neck
The CD98 heavy chain is a marker and regulator of head and neck squamous cell carcinoma radiosensitivity.
Stomach Neoplasms
Discovery of SLC3A2 cell membrane protein as a potential gastric cancer biomarker: implications in molecular imaging.
Stomach Neoplasms
SLC3A2, antigen of mAb 3G9, promotes migration and invasion by upregulating of mucins in gastric cancer.
Syphilis
Structural and Biochemical Basis for Polyamine Binding to the Tp0655 Lipoprotein of Treponema pallidum: Putative Role for Tp0655 (TpPotD) as a Polyamine Receptor.
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?
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x * 38000 + x * 45000 + x * 31000-35000 + x * 31000-35000, subunits PotF, PotG, PotH and PotI, calculated from amino acid sequence
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x * 38000 + x * 45000 + x * 35000 + x * 31000, subunits PotF, PotG, PotH and PotI, SDS-PAGE
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x * 40809 + x * 44782 + x * 35487 + x * 30539, subunits PotF, PotG, PotH and PotI, calculated from amino acid sequence
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x * 38000 + x * 45000 + x * 35000 + x * 31000, subunits PotF, PotG, PotH and PotI, SDS-PAGE
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?
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x * 40809 + x * 44782 + x * 35487 + x * 30539, subunits PotF, PotG, PotH and PotI, calculated from amino acid sequence
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monomer
1 * 39000, SDS-PAGE
monomer
1 * 34000, calculated from amino acid sequence
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Abdulhussein, A.A.; Wallace, H.M.
Polyamines and membrane transporters
Amino Acids
46
655-660
2014
Homo sapiens
brenda
Terui, Y.; Saroj, S.D.; Sakamoto, A.; Yoshida, T.; Higashi, K.; Kurihara, S.; Suzuki, H.; Toida, T.; Kashiwagi, K.; Igarashi, K.
Properties of putrescine uptake by PotFGHI and PuuP and their physiological significance in Escherichia coli
Amino Acids
46
661-670
2014
Escherichia coli, Escherichia coli W3110
brenda
Igarashi, K.; Kashiwagi, K.
Polyamine transport in bacteria and yeast
Biochem. J.
344
633-642
1999
Escherichia coli
brenda
Kurihara, S.; Tsuboi, Y.; Oda, S.; Kim, H.G.; Kumagai, H.; Suzuki, H.
The putrescine importer PuuP of Escherichia coli K-12
J. Bacteriol.
191
2776-2782
2009
Escherichia coli
brenda
Pistocchi, R.; Kashiwagi, K.; Miyamoto, S.; Nukui, E.; Sadakata, Y.; Kobayashi, H.; Igarashi, K.
Characteristics of the operon for a putrescine transport system that maps at 19 minutes on the Escherichia coli chromosome
J. Biol. Chem.
268
146-152
1993
Escherichia coli, Escherichia coli W3110
-
brenda
Kurihara, S.; Suzuki, H.; Oshida, M.; Benno, Y.
A novel putrescine importer required for type 1 pili-driven surface motility induced by extracellular putrescine in Escherichia coli K-12
J. Biol. Chem.
286
10185-10192
2011
Escherichia coli
brenda
Machius, M.; Brautigam, C.; Tomchick, D.; Ward, P.; Otwinowski, Z.; Blevins, J.; Deka, R.; Norgard, M.
Structural and biochemical basis for polyamine binding to the Tp0655 lipoprotein of Treponema pallidum Putative Role for Tp0655 (TpPotD) as a polyamine receptor
J. Mol. Biol.
373
681-694
2007
Treponema pallidum (O83661), Treponema pallidum
brenda
Igarashi, K.; Kashiwagi, K.
Characteristics of cellular polyamine transport in prokaryotes and eukaryotes
Plant Physiol. Biochem.
48
506-512
2010
Escherichia coli
brenda
Igarashi, K.; Ito, K.; Kashiwagi, K.
Polyamine uptake systems in Escherichia coli
Res. Microbiol.
152
271-278
2001
Escherichia coli
brenda