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Information on EC 7.6.2.15 - ABC-type thiamine transporter

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IUBMB Comments
ATP-binding cassette (ABC) type transporter, characterized by the presence of two similar ATP-binding domains/proteins and two integral membrane domains/proteins. The enzyme, characterized from the bacterium Salmonella typhimurium, is a heterodimeric complex that interacts with an extracytoplasmic substrate binding protein and functions to import thiamine, thiamine monophosphate and thiamine diphosphate.
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The enzyme appears in viruses and cellular organisms
Reaction Schemes
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thiamine-[thiamine-binding protein][side 1]
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[thiamine-binding protein][side 1]
Synonyms
CLIBASIA_02230, tbpABC, Thi, thiamin ABC transporter, thiamin transporting ATPase, thiamine ABC transporter, thiamine pyrophosphate ABC transporter, thiamine transporter, thiamine transporting ATPase, thiBPQ, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
ATP + H2O + thiamine-[thiamine-binding protein][side 1] = ADP + phosphate + thiamine[side 2] + [thiamine-binding protein][side 1]
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