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Information on EC 7.5.2.6 - ABC-type lipid A-core oligosaccharide transporter

for references in articles please use BRENDA:EC7.5.2.6
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IUBMB Comments
An ATP-binding cassette (ABC) type transporter, characterized by the presence of two similar ATP-binding domains/proteins and two integral membrane domains/proteins. The enzyme, best characterized from the bacterium Escherichia coli, is located in the inner membrane and mediates the movement of lipid A attached to the core oligosaccharide from the cytoplasm to the periplasmic side of the inner membrane, an important step in the lipopolysaccharide biosynthetic pathway. Not to be confused with EC 7.5.2.5, ABC-type lipopolysaccharide transporter (LptB), which is implicated in the translocation of LPS from the inner membrane to the outer membrane and acts later in the process.
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Word Map
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Reaction Schemes
+
+
lipopolysaccharide[side 1]
=
+
+
lipopolysaccharide[side 2]
+
+
lipid A-core oligosaccharide[side 1]
=
+
+
lipid A-core oligosaccharide[side 2]
Synonyms
ATP-dependent lipid A-core flippase, EcMsbA, lipid A export ATP-binding/permease protein, lipid A export ATP-binding/permease protein MsbA, Lipid A transporter, lipid flippase, LPS flippase, More, MsbA, MsbA protein, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
ATP + H2O + lipid A-core oligosaccharide[side 1] = ADP + phosphate + lipid A-core oligosaccharide[side 2]
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ATP + H2O + lipopolysaccharide[side 1] = ADP + phosphate + lipopolysaccharide[side 2]
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