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Information on EC 7.4.2.6 - ABC-type oligopeptide transporter
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EC Tree
7.4.2.6 ABC-type oligopeptide transporterIUBMB Comments
An ATP-binding cassette (ABC) type transporter, characterized by the presence of two similar ATP-binding domains/proteins and two integral membrane domains/proteins. Does not undergo phosphorylation during the transport process. A bacterial enzyme that interacts with an extracytoplasmic substrate binding protein and mediates the import of oligopeptides of varying nature. The binding protein determines the specificity of the system. cf. EC 7.4.2.9, ABC-type dipeptide transporter.
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Word Map
- 7.4.2.6
- dipeptide
- tripeptides
-
importins
-
proton-coupled
-
cargo
-
caco-2
-
prodrugs
-
hpept1
-
nucleocytoplasmic
-
glycylsarcosine
-
peptidomimetic
-
proton-dependent
-
gly-sar
- nucleoporins
- cephalexin
-
carrier-mediated
-
rangtp
-
peptide-like
-
pept1-mediated
-
slc15a1
-
karyopherins
-
importin-beta
- bestatin
-
ergic-53
- acyclovir
- cefadroxil
- ntf2
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Reaction Schemes
+
+
=
+
+
+
+
+
oligopeptide-[oligopeptide-binding protein][side 1]
=
+
+
oligopeptide[side 2]
+
[oligopeptide-binding protein][side 1]
Synonyms
oligopeptide transporter, transport receptor, oligopeptide permease, glutathione transporter, oligopeptide-binding protein, atopt6, oligopeptide transporter 1, scopt1, oligopeptide permease a, oligopeptide-binding protein a, 
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
BldK transporter
EC 3.6.3.23
-
-
formerly
-
oligogopeptide permease
oligogopeptide permease protein A
oligopeptide ABC transporter
oligopeptide permease
oligopeptide permease A
oligopeptide transporter
oligopeptide-binding protein
oligopeptide-transporting ATPase
-
-
-
-
Opp
Opp1
Opp3
OppA
OppF
PepT1
additional information
oligopeptide permease
-
-
-
-
Opp
the Opp system consists of five oligopeptide-binding proteins (OppA1 to OppA5), two heterodimeric cytoplasmic membrane permeases (OppB1C1 and OppB2C2), and a nucleotide-binding domain heterodimer (OppDF) that drives transport by hydrolyzing ATP
Opp
the Opp system consists of five oligopeptide-binding proteins (OppA1 to OppA5), two heterodimeric cytoplasmic membrane permeases (OppB1C1 and OppB2C2), and a nucleotide-binding domain heterodimer (OppDF) that drives transport by hydrolyzing ATP
-
OppA
-
the surface-localised substrate-binding domain OppA of the oligopeptide permease
additional information
-
AppA, OppA, and Dpp belong to the ATP-binding casette family, the ABC-type ATPases
additional information
the enzyme belongs to the oligopeptide transporters of the OPT family
additional information
-
Opt2 is a member of the oligopeptide transporter family
additional information
-
Opp enzymes belong to the ATP-binding casette family, the ABC-type ATPases
additional information
-
peptide transport systems involved in the signaling pathways belong to the superfamily of ATP-binding cassette, ABC, transporters composed of five protein subunits
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
ATP + H2O + oligopeptide-[oligopeptide-binding protein][side 1] = ADP + phosphate + oligopeptide[side 2] + [oligopeptide-binding protein][side 1]
-
-
-
-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
hydrolysis of phosphoric acid anhydride
-
-
-
-
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SYSTEMATIC NAME
IUBMB Comments
ATP phosphohydrolase (ABC-type, oligopeptide-importing)
An ATP-binding cassette (ABC) type transporter, characterized by the presence of two similar ATP-binding domains/proteins and two integral membrane domains/proteins. Does not undergo phosphorylation during the transport process. A bacterial enzyme that interacts with an extracytoplasmic substrate binding protein and mediates the import of oligopeptides of varying nature. The binding protein determines the specificity of the system. cf. EC 7.4.2.9, ABC-type dipeptide transporter.
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CAS REGISTRY NUMBER
COMMENTARY
9000-83-3
-
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
ATP + H2O + AtCLE19p12/out
ADP + phosphate + AtCLE19p12/in
-
in Xenopus laevis oocytes, injected with AtOPT6 cRNA
-
-
?
ATP + H2O + CLE/out
ADP + phosphate + CLE/in
-
in Xenopus laevis oocytes, injected with AtOPT6 cRNA, CLE is transported by AtOPT6 with high affinity
-
-
?
ATP + H2O + GGFM/out
ADP + phosphate + GGFM/in
-
in Xenopus laevis oocytes, injected with AtOPT6 cRNA
-
-
?
ATP + H2O + GGGQATGPPNTSYMPGMPGD-[GGGQATGPPNTSYMPGMPGD-binding protein][side 1]
ADP + phosphate + GGGQATGPPNTSYMPGMPGD[side 2] + [GGGQATGPPNTSYMPGMPGD-binding protein][side 1]
ATP + H2O + GSSG/out
ADP + phosphate + GSSG/in
-
in Xenopus laevis oocytes, injected with ScOPT1 cRNA
-
-
?
ATP + H2O + KLG/out
ADP + phosphate + KLG/in
-
in Xenopus laevis oocytes, injected with AtOPT6 cRNA
-
-
?
ATP + H2O + KLGL/out
ADP + phosphate + KLGL/in
-
in Xenopus laevis oocytes, injected with AtOPT6 cRNA
-
-
?
ATP + H2O + KLLLG/out
ADP + phosphate + KLLLG/in
-
in Xenopus laevis oocytes, injected with AtOPT6 cRNA
-
-
?
ATP + H2O + KLLLLG/out
ADP + phosphate + KLLLLG/in
-
in Xenopus laevis oocytes, injected with AtOPT6 cRNA
-
-
?
ATP + H2O + oligopeptide-[oligopeptide-binding protein][side 1]
ADP + phosphate + oligopeptide[side 2] + [oligopeptide-binding protein][side 1]
ATP + H2O + phosphinotricyl-alanyl-alanine/out
ADP + phosphate + phosphinotricyl-alanyl-alanine/in
ATP + H2O + X-Ala-Ala-Ala-[X-Ala-Ala-Ala-binding protein][side 1]
ADP + phosphate + X-Ala-Ala-Ala[side 2] + [X-Ala-Ala-Ala-binding protein][side 1]
ATP + H2O + bradykinin/out
ADP + phosphate + bradykinin/in
i.e. RPPGFSPFR, specific for isozyme OppA2
-
-
?
ATP + H2O + bradykinin/out
ADP + phosphate + bradykinin/in
i.e. RPPGFSPFR, specific for isozyme OppA2, ATP hydrolysis is coupled to peptide translocation
-
-
?
ATP + H2O + GGFL/out
ADP + phosphate + GGFL/in
-
in Xenopus laevis oocytes, injected with AtOPT6 cRNA. GGFL-induced currents are pH-dependent
-
-
?
ATP + H2O + GGFL/out
ADP + phosphate + GGFL/in
-
in Xenopus laevis oocytes, injected with ScOPT1 cRNA
-
-
?
ATP + H2O + GGGQATGPPNTSYMPGMPGD-[GGGQATGPPNTSYMPGMPGD-binding protein][side 1]
ADP + phosphate + GGGQATGPPNTSYMPGMPGD[side 2] + [GGGQATGPPNTSYMPGMPGD-binding protein][side 1]
-
-
-
?
ATP + H2O + GGGQATGPPNTSYMPGMPGD-[GGGQATGPPNTSYMPGMPGD-binding protein][side 1]
ADP + phosphate + GGGQATGPPNTSYMPGMPGD[side 2] + [GGGQATGPPNTSYMPGMPGD-binding protein][side 1]
-
-
-
?
ATP + H2O + GSH/out
ADP + phosphate + GSH/in
-
in Xenopus laevis oocytes, injected with AtOPT6 cRNA. GSH-induced currents are pH-dependent, low affinity GSH transport of AtOPT6
-
-
?
ATP + H2O + GSH/out
ADP + phosphate + GSH/in
-
in Xenopus laevis oocytes, injected with ScOPT1 cRNA
-
-
?
ATP + H2O + oligopeptide-[oligopeptide-binding protein][side 1]
ADP + phosphate + oligopeptide[side 2] + [oligopeptide-binding protein][side 1]
-
-
-
?
ATP + H2O + oligopeptide-[oligopeptide-binding protein][side 1]
ADP + phosphate + oligopeptide[side 2] + [oligopeptide-binding protein][side 1]
-
-
-
?
ATP + H2O + oligopeptide/out
ADP + phosphate + oligopeptide/in
-
-
-
?
ATP + H2O + oligopeptide/out
ADP + phosphate + oligopeptide/in
-
the enzyme is required for expression of the srf operon in response to changes in culture pH
-
?
ATP + H2O + oligopeptide/out
ADP + phosphate + oligopeptide/in
-
the enzyme imports exogenous peptides that play roles as source of amino acids and in the signalling pathways leading to development of competence and sporulation, overview
-
-
?
ATP + H2O + oligopeptide/out
ADP + phosphate + oligopeptide/in
-
ATP hydrolysis is coupled to peptide translocation, the enzyme has a lipid-modified, membrane-anchored extracellular protein binding domain which serve as a receptor for the system, peptide ligand pocket structure of AppA, overview
-
-
?
ATP + H2O + oligopeptide/out
ADP + phosphate + oligopeptide/in
-
-
-
?
ATP + H2O + oligopeptide/out
ADP + phosphate + oligopeptide/in
-
-
-
?
ATP + H2O + oligopeptide/out
ADP + phosphate + oligopeptide/in
-
-
-
?
ATP + H2O + oligopeptide/out
ADP + phosphate + oligopeptide/in
-
-
-
?
ATP + H2O + oligopeptide/out
ADP + phosphate + oligopeptide/in
-
transport of the phytotoxic tripeptide phaseolotoxin into E. coli cells or cells of Salmonella typhimurium. Mutants defective in oligopeptide permease are resistant to phaseolotoxin
-
?
ATP + H2O + oligopeptide/out
ADP + phosphate + oligopeptide/in
-
the genes of the trp-linked opp operon are subject to transcriptional regulation, their expression is elevated by supplementation of the growth medium with either L-Leu or L-Ala and by growth of the opp-lac fusion-containing strains under anaerobic conditions
-
-
?
ATP + H2O + oligopeptide/out
ADP + phosphate + oligopeptide/in
-
growth of E. coli in the presence of Leu results in increased synthesis of the OppA-encoded periplasmic binding protein
-
?
ATP + H2O + oligopeptide/out
ADP + phosphate + oligopeptide/in
-
-
-
?
ATP + H2O + oligopeptide/out
ADP + phosphate + oligopeptide/in
-
-
-
?
ATP + H2O + oligopeptide/out
ADP + phosphate + oligopeptide/in
-
-
-
?
ATP + H2O + oligopeptide/out
ADP + phosphate + oligopeptide/in
-
-
-
?
ATP + H2O + oligopeptide/out
ADP + phosphate + oligopeptide/in
-
transport of the phytotoxic tripeptide phaseolotoxin into E. coli cells or cells of Salmonella typhimurium. Mutants defective in oligopeptide permease are resistant to phaseolotoxin
-
?
ATP + H2O + oligopeptide/out
ADP + phosphate + oligopeptide/in
-
enzyme plays an important nutritional role and is required for the recycling of cell wall peptides
-
?
ATP + H2O + oligopeptide/out
ADP + phosphate + oligopeptide/in
-
the Ami transporter is involved in the regulatory pathway that controls the induction of the competence state in Streptococcus thermophilus, and also that natural transformation can be turned on in CDM during the exponential growth phase, oligopeptide-binding protein AmiA3 plays the major role, overview
-
-
?
ATP + H2O + oligopeptide/out
ADP + phosphate + oligopeptide/in
-
-
-
?
ATP + H2O + oligopeptide/out
ADP + phosphate + oligopeptide/in
-
-
-
-
?
ATP + H2O + oligopeptide/out
ADP + phosphate + oligopeptide/in
-
the enzyme is responsible for the import of an extracellular signal governing aerial mycelium formation
-
?
ATP + H2O + oligopeptide/out
ADP + phosphate + oligopeptide/in
-
a 655 Da oligopeptide
-
-
?
ATP + H2O + oligopeptide/out
ADP + phosphate + oligopeptide/in
-
-
-
-
?
ATP + H2O + oligopeptide/out
ADP + phosphate + oligopeptide/in
-
a 655 Da oligopeptide
-
-
?
ATP + H2O + oligopeptide/out
ADP + phosphate + oligopeptide/in
-
-
-
-
?
ATP + H2O + oligopeptide/out
ADP + phosphate + oligopeptide/in
-
a 655 Da oligopeptide
-
-
?
ATP + H2O + oligopeptide/out
ADP + phosphate + oligopeptide/in
-
-
-
-
?
ATP + H2O + oligopeptide/out
ADP + phosphate + oligopeptide/in
-
a 655 Da oligopeptide
-
-
?
ATP + H2O + olipopeptide/out
ADP + phosphate + oligopeptide/in
-
the extracytoplasmic lipid-anchored substrate-binding protein, or receptor, OppA delivers peptides to an integral membrane complex OppBCDF, or translocator, where, on ATP binding and hydrolysis, translocation across the membrane takes place, mechanism studied in model membrane vesicles, overview
-
-
?
ATP + H2O + olipopeptide/out
ADP + phosphate + oligopeptide/in
-
-
-
-
?
ATP + H2O + olipopeptide/out
ADP + phosphate + oligopeptide/in
-
the enzyme binds peptides of 3 to 16 amino acids, regardless of the presence of arginine in the peptide
-
-
?
ATP + H2O + olipopeptide/out
ADP + phosphate + oligopeptide/in
-
the enzyme binds peptides of 3 to 16 amino acids, regardless of the presence of arginine in the peptide
-
-
?
ATP + H2O + olipopeptide/out
ADP + phosphate + oligopeptide/in
-
-
-
-
?
ATP + H2O + olipopeptide/out
ADP + phosphate + oligopeptide/in
-
oligopeptides internalized by oligopeptide permease transporters play key roles in bacterial nutrition, signaling, and virulence, opp-3 is the only transporter to be regulated by specific amino acids, tyrosine and phenylalanine at the transcription level, and Opp-3 appears to be the main Opp system supplying the cell with peptides as nutritional sources, overview
-
-
?
ATP + H2O + olipopeptide/out
ADP + phosphate + oligopeptide/in
-
-
-
-
?
ATP + H2O + olipopeptide/out
ADP + phosphate + oligopeptide/in
-
-
-
?
ATP + H2O + olipopeptide/out
ADP + phosphate + oligopeptide/in
Hly-OppA has multiple functions in solute binding, in in vitro hemolysis, in antibiotic resistance, and as a virulence factor in bacterial pathogenesis, overview
-
-
?
ATP + H2O + olipopeptide/out
ADP + phosphate + oligopeptide/in
-
-
-
-
?
ATP + H2O + olipopeptide/out
ADP + phosphate + oligopeptide/in
-
the oligopeptide-binding protein, OppA, binds and ushers oligopeptide substrates to the membrane-associated oligopeptide permease, Opp, a multi-component ABC-type transporter involved in the uptake of oligopeptides
-
-
?
ATP + H2O + phosphinotricyl-alanyl-alanine/out
ADP + phosphate + phosphinotricyl-alanyl-alanine/in
import of the toxic tripeptide, isozymes OppA1 and OppA2
-
-
?
ATP + H2O + phosphinotricyl-alanyl-alanine/out
ADP + phosphate + phosphinotricyl-alanyl-alanine/in
a toxic tripeptide, isozymes OppA1 and OppA2, ATP hydrolysis is coupled to peptide translocation
-
-
?
ATP + H2O + phytochelatin/out
ADP + phosphate + phytochelatin/in
-
i.e. (gamma -Glu-Cys) 2 -Gly, in Xenopus laevis oocytes, injected with AtOPT6 cRNA
-
-
?
ATP + H2O + phytochelatin/out
ADP + phosphate + phytochelatin/in
-
i.e. (gamma -Glu-Cys) 2 -Gly, in Xenopus laevis oocytes, injected with ScOPT1 cRNA
-
-
?
ATP + H2O + polar amino acid/out
ADP + phosphate + polar amino acid/in
-
-
-
-
?
ATP + H2O + polar amino acid/out
ADP + phosphate + polar amino acid/in
-
-
-
-
?
ATP + H2O + X-Ala-Ala-Ala-[X-Ala-Ala-Ala-binding protein][side 1]
ADP + phosphate + X-Ala-Ala-Ala[side 2] + [X-Ala-Ala-Ala-binding protein][side 1]
-
-
-
?
ATP + H2O + X-Ala-Ala-Ala-[X-Ala-Ala-Ala-binding protein][side 1]
ADP + phosphate + X-Ala-Ala-Ala[side 2] + [X-Ala-Ala-Ala-binding protein][side 1]
-
-
-
?
additional information
?
-
-
AtOPT6 displays high affinity for penta- and dodecapeptides, but low affinity for GSH, substrate specificity of AtOPT6, inward currents caused by KLLG and KLLLG application are 3 to 7fold greater than with KLG, overview
-
-
?
additional information
?
-
-
enzyme stimulates competence development and the initiation of sporulation by importing specific signaling peptides
-
-
?
additional information
?
-
-
substrate binding proteins OppA1, OppA2 show preference for tripeptides over dipeptides and loger-chain peptides. OppA1 is able to accomodate peptides composed of bulky residues, OppA2 and OppA3 prefer peptides composed of small nonpolar amino acids. All three Opp proteins prefer L-amino acids rather than D-amino acids
-
-
?
additional information
?
-
-
the Borrelia burgdorferi oligopeptide permease contains five different substrate binding proteins, i.e. OppA proteins, that interact with the integral membrane components of the transporter, expression of the OppA proteins is individually regulated and may play different roles in adaptation to host environments, overview
-
-
?
additional information
?
-
-
the Borrelia burgdorferi oligopeptide permease contains five different substrate binding proteins, i.e. OppA proteins, that interact with the integral membrane components of the transporter, expression of the OppA proteins is individually regulated and may play different roles in adaptation to host environments, overview
-
-
?
additional information
?
-
-
OppA protein does not play a direct role in the sensitivity to aminoglycosides in Escherichia coli K12, overview
-
-
?
additional information
?
-
-
OppA protein does not play a direct role in the sensitivity to aminoglycosides in Escherichia coli K12, overview
-
-
?
additional information
?
-
PepT1 may play an important role in the larval nutrition since it is widely expressed in the digestive tract, PepT1 expression depends on the diet, overview
-
-
?
additional information
?
-
-
PepT1 may play an important role in the larval nutrition since it is widely expressed in the digestive tract, PepT1 expression depends on the diet, overview
-
-
?
additional information
?
-
-
the enzyme follows a mechanism for peptide selection based on amino-acid composition rather than sequence, overview
-
-
?
additional information
?
-
-
OppA binds peptides of an exceptionally wide range of lengths of 4 to 35 residues with no apparent sequence preference. A huge cavity allows binding of very long peptides, and a lack of constraints for the position of the N and C termini of the ligand is compatible with binding of peptides with varying lengths, e.g. bradykinin, RPPGFSPFR
-
-
?
additional information
?
-
-
the enzyme does not have a specific affinity for peptides containing arginine
-
-
?
additional information
?
-
-
the enzyme does not have a specific affinity for peptides containing arginine
-
-
?
additional information
?
-
-
the ecto-ATPase OppA, the surface-localized substrate-binding domain of the oligopeptide permease, of Mycoplasma hominis induces ATP release and both apoptotic and necrotic cell death in HeLa cells, overview
-
-
?
additional information
?
-
-
ScOPT1 substrate specificity, overview. KLLLG, RPPGF, DRVYIHPF or AtCLE19p12 cause no inward currents in ScOPT1-expressing oocytes
-
-
?
additional information
?
-
-
opp3 participates in extracellular protease regulation during growth in milk
-
-
?
additional information
?
-
-
opp3 participates in extracellular protease regulation during growth in milk
-
-
?
additional information
?
-
-
OppA is important in pathogenesis of group A streptococci
-
-
?
additional information
?
-
-
the oligopeptide transport system is essential for the development of natural competence in Streptococcus thermophilus strain LMD-9, mutational analysis, overview
-
-
?
additional information
?
-
the two isozymes OppA1 and OppA2 are essential for production of beta-lactamase inhibitor clavulinic acid
-
-
?
additional information
?
-
isozyme OppA is involved in biofilm formation in Vibrio fluvialis
-
-
?
additional information
?
-
isozyme OppA is involved in biofilm formation in Vibrio fluvialis
-
-
?
additional information
?
-
isozyme OppA is involved in biofilm formation in Vibrio fluvialis
-
-
?
additional information
?
-
isozyme OppA is involved in biofilm formation in Vibrio fluvialis
-
-
?
additional information
?
-
isozyme OppA is involved in biofilm formation in Vibrio fluvialis
-
-
?
additional information
?
-
-
isozyme OppA is involved in biofilm formation in Vibrio fluvialis
-
-
?
additional information
?
-
Vibrio fluvialis KCTC 2473 / ATCC 33809
isozyme OppA is involved in biofilm formation in Vibrio fluvialis
-
-
?
additional information
?
-
Vibrio fluvialis KCTC 2473 / ATCC 33809
isozyme OppA is involved in biofilm formation in Vibrio fluvialis
-
-
?
additional information
?
-
Vibrio fluvialis KCTC 2473 / ATCC 33809
isozyme OppA is involved in biofilm formation in Vibrio fluvialis
-
-
?
additional information
?
-
Vibrio fluvialis KCTC 2473 / ATCC 33809
isozyme OppA is involved in biofilm formation in Vibrio fluvialis
-
-
?
additional information
?
-
Vibrio fluvialis KCTC 2473 / ATCC 33809
isozyme OppA is involved in biofilm formation in Vibrio fluvialis
-
-
?
additional information
?
-
the purified protein exhibits host-specific in vitro hemolytic activity against various mammalian erythrocytes and apparent cytotoxicity in CHO-K1 cells
-
-
?
additional information
?
-
-
the purified protein exhibits host-specific in vitro hemolytic activity against various mammalian erythrocytes and apparent cytotoxicity in CHO-K1 cells
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
ATP + H2O + bradykinin/out
ADP + phosphate + bradykinin/in
i.e. RPPGFSPFR, specific for isozyme OppA2
-
-
?
ATP + H2O + oligopeptide-[oligopeptide-binding protein][side 1]
ADP + phosphate + oligopeptide[side 2] + [oligopeptide-binding protein][side 1]
ATP + H2O + phosphinotricyl-alanyl-alanine/out
ADP + phosphate + phosphinotricyl-alanyl-alanine/in
import of the toxic tripeptide, isozymes OppA1 and OppA2
-
-
?
ATP + H2O + oligopeptide-[oligopeptide-binding protein][side 1]
ADP + phosphate + oligopeptide[side 2] + [oligopeptide-binding protein][side 1]
-
-
-
?
ATP + H2O + oligopeptide-[oligopeptide-binding protein][side 1]
ADP + phosphate + oligopeptide[side 2] + [oligopeptide-binding protein][side 1]
-
-
-
?
ATP + H2O + oligopeptide/out
ADP + phosphate + oligopeptide/in
-
the enzyme is required for expression of the srf operon in response to changes in culture pH
-
?
ATP + H2O + oligopeptide/out
ADP + phosphate + oligopeptide/in
-
the enzyme imports exogenous peptides that play roles as source of amino acids and in the signalling pathways leading to development of competence and sporulation, overview
-
-
?
ATP + H2O + oligopeptide/out
ADP + phosphate + oligopeptide/in
-
transport of the phytotoxic tripeptide phaseolotoxin into E. coli cells or cells of Salmonella typhimurium. Mutants defective in oligopeptide permease are resistant to phaseolotoxin
-
?
ATP + H2O + oligopeptide/out
ADP + phosphate + oligopeptide/in
-
the genes of the trp-linked opp operon are subject to transcriptional regulation, their expression is elevated by supplementation of the growth medium with either L-Leu or L-Ala and by growth of the opp-lac fusion-containing strains under anaerobic conditions
-
-
?
ATP + H2O + oligopeptide/out
ADP + phosphate + oligopeptide/in
-
growth of E. coli in the presence of Leu results in increased synthesis of the OppA-encoded periplasmic binding protein
-
?
ATP + H2O + oligopeptide/out
ADP + phosphate + oligopeptide/in
-
transport of the phytotoxic tripeptide phaseolotoxin into E. coli cells or cells of Salmonella typhimurium. Mutants defective in oligopeptide permease are resistant to phaseolotoxin
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?
ATP + H2O + oligopeptide/out
ADP + phosphate + oligopeptide/in
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enzyme plays an important nutritional role and is required for the recycling of cell wall peptides
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?
ATP + H2O + oligopeptide/out
ADP + phosphate + oligopeptide/in
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the Ami transporter is involved in the regulatory pathway that controls the induction of the competence state in Streptococcus thermophilus, and also that natural transformation can be turned on in CDM during the exponential growth phase, oligopeptide-binding protein AmiA3 plays the major role, overview
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?
ATP + H2O + oligopeptide/out
ADP + phosphate + oligopeptide/in
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the enzyme is responsible for the import of an extracellular signal governing aerial mycelium formation
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?
ATP + H2O + oligopeptide/out
ADP + phosphate + oligopeptide/in
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a 655 Da oligopeptide
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-
?
ATP + H2O + oligopeptide/out
ADP + phosphate + oligopeptide/in
-
a 655 Da oligopeptide
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-
?
ATP + H2O + oligopeptide/out
ADP + phosphate + oligopeptide/in
-
a 655 Da oligopeptide
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-
?
ATP + H2O + oligopeptide/out
ADP + phosphate + oligopeptide/in
-
a 655 Da oligopeptide
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-
?
ATP + H2O + olipopeptide/out
ADP + phosphate + oligopeptide/in
-
the extracytoplasmic lipid-anchored substrate-binding protein, or receptor, OppA delivers peptides to an integral membrane complex OppBCDF, or translocator, where, on ATP binding and hydrolysis, translocation across the membrane takes place, mechanism studied in model membrane vesicles, overview
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?
ATP + H2O + olipopeptide/out
ADP + phosphate + oligopeptide/in
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-
-
-
?
ATP + H2O + olipopeptide/out
ADP + phosphate + oligopeptide/in
-
the enzyme binds peptides of 3 to 16 amino acids, regardless of the presence of arginine in the peptide
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-
?
ATP + H2O + olipopeptide/out
ADP + phosphate + oligopeptide/in
-
the enzyme binds peptides of 3 to 16 amino acids, regardless of the presence of arginine in the peptide
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-
?
ATP + H2O + olipopeptide/out
ADP + phosphate + oligopeptide/in
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-
-
-
?
ATP + H2O + olipopeptide/out
ADP + phosphate + oligopeptide/in
-
oligopeptides internalized by oligopeptide permease transporters play key roles in bacterial nutrition, signaling, and virulence, opp-3 is the only transporter to be regulated by specific amino acids, tyrosine and phenylalanine at the transcription level, and Opp-3 appears to be the main Opp system supplying the cell with peptides as nutritional sources, overview
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?
ATP + H2O + olipopeptide/out
ADP + phosphate + oligopeptide/in
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-
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-
?
ATP + H2O + olipopeptide/out
ADP + phosphate + oligopeptide/in
Hly-OppA has multiple functions in solute binding, in in vitro hemolysis, in antibiotic resistance, and as a virulence factor in bacterial pathogenesis, overview
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-
?
ATP + H2O + olipopeptide/out
ADP + phosphate + oligopeptide/in
-
the oligopeptide-binding protein, OppA, binds and ushers oligopeptide substrates to the membrane-associated oligopeptide permease, Opp, a multi-component ABC-type transporter involved in the uptake of oligopeptides
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-
?
ATP + H2O + polar amino acid/out
ADP + phosphate + polar amino acid/in
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-
-
-
?
ATP + H2O + polar amino acid/out
ADP + phosphate + polar amino acid/in
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-
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?
additional information
?
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-
enzyme stimulates competence development and the initiation of sporulation by importing specific signaling peptides
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-
?
additional information
?
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the Borrelia burgdorferi oligopeptide permease contains five different substrate binding proteins, i.e. OppA proteins, that interact with the integral membrane components of the transporter, expression of the OppA proteins is individually regulated and may play different roles in adaptation to host environments, overview
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-
?
additional information
?
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the Borrelia burgdorferi oligopeptide permease contains five different substrate binding proteins, i.e. OppA proteins, that interact with the integral membrane components of the transporter, expression of the OppA proteins is individually regulated and may play different roles in adaptation to host environments, overview
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?
additional information
?
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OppA protein does not play a direct role in the sensitivity to aminoglycosides in Escherichia coli K12, overview
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?