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Information on EC 7.4.2.5 - bacterial ABC-type protein transporter
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7.4.2.5 bacterial ABC-type protein transporterIUBMB Comments
An ATP-binding cassette (ABC) type transporter, characterized by the presence of two similar ATP-binding domains/proteins and two integral membrane domains/proteins. This entry stands for a family of bacterial enzymes that are dedicated to the secretion of one or several closely related proteins belonging to the toxin, protease and lipase families. Examples from Gram-negative bacteria include alpha-hemolysin, cyclolysin, colicin V and siderophores, while examples from Gram-positive bacteria include bacteriocin, subtilin, competence factor and pediocin.
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Word Map
- 7.4.2.5
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caco-2
- tripeptides
- jejunum
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gly-sar
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glycylsarcosine
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secyeg
- xenopus
- oocyte
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histocompatibility
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multidrug
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prodrugs
- p-glycoprotein
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enterocytes
- duodenum
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peptidomimetic
- beta-lactams
- preproteins
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basolateral
- ileum
- cephalexin
- laevis
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peptide-like
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translocons
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transepithelial
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brush-border
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carrier-mediated
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h+-coupled
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villus
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electrogenic
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pepts
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proton-dependent
- valacyclovir
- acyclovir
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transporter-mediated
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tapasin
- carnosine
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sec-dependent
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paracellular
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membrane-embedded
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two-electrode
- bestatin
- oct1
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oatp2b1
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oatps
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antigen-processing
- gly-gly
- cefixime
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i-restricted
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apical-to-basolateral
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serine-rich
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota
Synonyms
pept1, peptide transporter, pept2, seca2, abc transport, seca protein, peptide transporter 1, abcb10, seca1, seca atpase, 
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
peptide-transporting ATPase
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
transmembrane transport
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hydolysis of phosphoric ester
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SYSTEMATIC NAME
IUBMB Comments
ATP phosphohydrolase (ABC-type, peptide-exporting)
An ATP-binding cassette (ABC) type transporter, characterized by the presence of two similar ATP-binding domains/proteins and two integral membrane domains/proteins. This entry stands for a family of bacterial enzymes that are dedicated to the secretion of one or several closely related proteins belonging to the toxin, protease and lipase families. Examples from Gram-negative bacteria include alpha-hemolysin, cyclolysin, colicin V and siderophores, while examples from Gram-positive bacteria include bacteriocin, subtilin, competence factor and pediocin.
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CAS REGISTRY NUMBER
COMMENTARY
9000-83-3
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
ATP + H2O + glycyl-sarcosine/in
ADP + phosphate + glycyl-sarcosine/out
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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Adenocarcinoma
ABCB2 (TAP1) as the downstream target of SHH signaling enhances pancreatic ductal adenocarcinoma drug resistance.
Adenocarcinoma
Targeted delivery to PEPT1-overexpressing cells: acidic, basic, and secondary floxuridine amino acid ester prodrugs.
Adrenoleukodystrophy
ATP-binding-cassette (ABC) transport systems: functional and structural aspects of the ATP-hydrolyzing subunits/domains.
Anemia
Abcb10 role in heme biosynthesis in vivo: Abcb10 knockout in mice causes anemia with protoporphyrin IX and iron accumulation.
Anemia
Fermented goat milk consumption during anaemia recovery: ergogenic effect and improvement of skeletal muscle homeostasis.
Anemia, Sideroblastic
Abcb10 role in heme biosynthesis in vivo: Abcb10 knockout in mice causes anemia with protoporphyrin IX and iron accumulation.
Arthritis, Rheumatoid
Peptide transporter genes (TAP) polymorphisms and genetic susceptibility to rheumatoid arthritis.
bacterial abc-type protein transporter deficiency
CD1 expression is not affected by human peptide transporter deficiency.
bacterial abc-type protein transporter deficiency
Cytosolic expression of SecA2 is a prerequisite for long-term protective immunity.
bacterial abc-type protein transporter deficiency
Human peptide transporter deficiency: importance of HLA-B in the presentation of TAP-independent EBV antigens.
Brain Injuries, Traumatic
Apoptosis and functional changes of dipeptide transporter (PepT1) in the rat small intestine after traumatic brain injury.
Brain Neoplasms
Expression of peptide transporter 1?has a positive correlation in protoporphyrin IX accumulation induced by 5-aminolevulinic acid with photodynamic detection of non-small cell lung cancer and metastatic brain tumor specimens originating from non-small cell lung cancer.
Breast Neoplasms
5-Fluorouracil treatment alters the expression of intestinal transporters in rats.
Breast Neoplasms
9-Deazapurines as Broad-Spectrum Inhibitors of the ABC Transport Proteins P-Glycoprotein, Multidrug Resistance-Associated Protein 1, and Breast Cancer Resistance Protein.
Breast Neoplasms
A Decade's Review of miRNA: a Center of Transcriptional Regulation of Drug-Metabolizing Enzymes and Transporters Under Hypoxia.
Breast Neoplasms
Abundant Expression of OCT2, MATE1, OAT1, OAT3, PEPT2, BCRP, MDR1, and xCT Transporters in Blood-Arachnoid Barrier of Pig and Polarized Localizations at CSF- and Blood-Facing Plasma Membranes.
Breast Neoplasms
BCRP gene expression is associated with a poor response to remission induction therapy in childhood acute myeloid leukemia.
Breast Neoplasms
Breast cancer resistance protein (BCRP/ABCG2) is expressed by progenitor cells/reactive ductules and hepatocytes and its expression pattern is influenced by disease etiology and species type: possible functional consequences.
Breast Neoplasms
Broad-spectrum modulation of ATP-binding cassette transport proteins by the taxane derivatives ortataxel (IDN-5109, BAY 59-8862) and tRA96023.
Breast Neoplasms
Correlation between Multi-Drug Resistance-Associated Membrane Transport in Clonal Cancer Cells and the Cell Cycle Phase.
Breast Neoplasms
Drug transporters in the lung--do they play a role in the biopharmaceutics of inhaled drugs?
Breast Neoplasms
Effect of ?-elemene on the kinetics of intracellular transport of d-luciferin potassium salt (ABC substrate) in doxorubicin-resistant breast cancer cells and the associated molecular mechanism.
Breast Neoplasms
Expression and localisation of breast cancer resistance protein (BCRP) in human fetal membranes and decidua and the influence of labour at term.
Breast Neoplasms
Expression and localization of BCRP, MRP1 and MRP2 in intestines, liver and kidney in horse.
Breast Neoplasms
Expression of the BCRP gene (ABCG2/MXR/ABCP) in childhood acute lymphoblastic leukaemia.
Breast Neoplasms
HER-2/neu-mediated regulation of components of the MHC class I antigen-processing pathway.
Breast Neoplasms
Impact of a high-cholesterol diet on expression levels of Niemann-Pick C1-like 1 and intestinal transporters in rats and mice.
Breast Neoplasms
In Vivo Gene Expression Profile of Human Intestinal Epithelial Cells: From the Viewpoint of Drug Metabolism and Pharmacokinetics.
Breast Neoplasms
Microvillus-Specific Protein Tyrosine Phosphatase SAP-1 Plays a Role in Regulating the Intestinal Paracellular Transport of Macromolecules.
Breast Neoplasms
Overexpression of microRNA-24 increases the sensitivity to paclitaxel in drug-resistant breast carcinoma cell lines via targeting ABCB9.
Breast Neoplasms
P-glycoprotein and breast cancer resistance protein expression and function at the blood-brain barrier and blood-cerebrospinal fluid barrier (choroid plexus) in streptozotocin-induced diabetes in rats.
Breast Neoplasms
Protein Abundance of Clinically Relevant Drug Transporters in the Human Liver and Intestine: A Comparative Analysis in Paired Tissue Specimens.
Breast Neoplasms
Selective Fusion of Heterogeneous Classifiers for Predicting Substrates of Membrane Transporters.
Breast Neoplasms
Taxane-based reversal agents modulate drug resistance mediated by P-glycoprotein, multidrug resistance protein, and breast cancer resistance protein.
Breast Neoplasms
Tissue Distribution, Ontogeny, and Hormonal Regulation of Xenobiotic Transporters in Mouse Kidneys.
Breast Neoplasms
Transporters in the Mammary Gland-Contribution to Presence of Nutrients and Drugs into Milk.
Breast Neoplasms
Using Ex Vivo Porcine Jejunum to Identify Membrane Transporter Substrates: A Screening Tool for Early-Stage Drug Development.
Breast Neoplasms
[Development of an In Vitro System for Evaluating Intestinal Drug Disposition Using Human Induced Pluripotent Stem Cell-Derived Intestinal Epithelial Cells].
Breast Neoplasms
[MDR (multidrug resistance) in hepatocarcinoma clinical-therapeutic implications]
Burkitt Lymphoma
Class I processing-defective Burkitt's lymphoma cells are recognized efficiently by CD4+ EBV-specific CTLs.
Burkitt Lymphoma
Engagement of CD40 antigen with soluble CD40 ligand up-regulates peptide transporter expression and restores endogenous processing function in Burkitt's lymphoma cells.
Carcinogenesis
Critical role of PepT1 in promoting colitis-associated cancer and therapeutic benefits of the anti-inflammatory PepT1-mediated tripeptide KPV in a murine model.
Carcinoma
CIAPIN1 and ABCA13 are markers of poor survival in metastatic ovarian serous carcinoma.
Carcinoma
Circular RNA ABCB10 contributes to laryngeal squamous cell carcinoma (LSCC) progression by modulating the miR-588/CXCR4 axis.
Carcinoma
Circular RNA ABCB10 promotes tumor progression and correlates with pejorative prognosis in clear cell renal cell carcinoma.
Carcinoma
Comprehensive Analysis of the ATP-binding Cassette Subfamily B Across Renal Cancers Identifies ABCB8 Overexpression in Phenotypically Aggressive Clear Cell Renal Cell Carcinoma.
Carcinoma
Deficient expression of components of the MHC class I antigen processing machinery in human cervical carcinoma.
Carcinoma
Nrf2 regulates the expression of the peptide transporter PEPT1 in the human colon carcinoma cell line Caco-2.
Carcinoma
Specific expression of proton-coupled oligopeptide transporter 1 in primary hepatocarcinoma-a novel strategy for tumor-targeted therapy.
Carcinoma
The Radiolabeling of a Gly-Sar Dipeptide Derivative with Flourine-18 and Its Use as a Potential Peptide Transporter PET Imaging Agent.
Carcinoma
Tumor necrosis factor-alpha and interferon-gamma increase PepT1 expression and activity in the human colon carcinoma cell line Caco-2/bbe and in mouse intestine.
Carcinoma, Hepatocellular
Circular RNA ABCB10 promotes hepatocellular carcinoma progression by increasing HMG20A expression by sponging miR-670-3p.
Carcinoma, Hepatocellular
Retraction Note to: Circular RNA ABCB10 promotes hepatocellular carcinoma progression by increasing HMG20A expression by sponging miR-670-3p.
Carcinoma, Hepatocellular
Targeting PEPT1: a novel strategy to improve the antitumor efficacy of doxorubicin in human hepatocellular carcinoma therapy.
Carcinoma, Non-Small-Cell Lung
ABCA3 Phenotype in Non-Small Cell Lung Cancer Indicates Poor Outcome.
Carcinoma, Non-Small-Cell Lung
Circular RNA ABCB10 promotes non-small cell lung cancer progression by increasing E2F5 expression through sponging miR-584-5p.
Carcinoma, Non-Small-Cell Lung
Expression of peptide transporter 1?has a positive correlation in protoporphyrin IX accumulation induced by 5-aminolevulinic acid with photodynamic detection of non-small cell lung cancer and metastatic brain tumor specimens originating from non-small cell lung cancer.
Carcinoma, Non-Small-Cell Lung
MicroRNA-31 inhibits cisplatin-induced apoptosis in non-small cell lung cancer cells by regulating the drug transporter ABCB9.
Carcinoma, Ovarian Epithelial
Circular RNA ABCB10 correlates with advanced clinicopathological features and unfavorable survival, and promotes cell proliferation while reduces cell apoptosis in epithelial ovarian cancer.
Carcinoma, Ovarian Epithelial
Circular RNA ABCB10 promotes cell proliferation and invasion, but inhibits apoptosis via regulating the microRNA?1271?mediated Capn4/Wnt/??catenin signaling pathway in epithelial ovarian cancer.
Carcinoma, Renal Cell
Circular RNA ABCB10 promotes tumor progression and correlates with pejorative prognosis in clear cell renal cell carcinoma.
Carcinoma, Renal Cell
Comprehensive Analysis of the ATP-binding Cassette Subfamily B Across Renal Cancers Identifies ABCB8 Overexpression in Phenotypically Aggressive Clear Cell Renal Cell Carcinoma.
Cardiomyopathies
Cardiotoxicity of doxorubicin is mediated through mitochondrial iron accumulation.
Cardiomyopathies
Disruption of ATP-binding cassette B8 in mice leads to cardiomyopathy through a decrease in mitochondrial iron export.
Cholera
Inhibition of the H+/peptide cotransporter in the human intestinal cell line Caco-2 by cyclic AMP.
Chorioamnionitis
Chorioamnionitis Induces a Specific Signature of Placental ABC Transporters Associated with an Increase of miR-331-5p in the Human Preterm Placenta.
Choriocarcinoma
Lidocine potentiates the cytotoxicity of 5-fluorouracil to choriocarcinoma cells by downregulating ABC transport proteins expression.
Colitis
Colonic Expression of the Peptide Transporter PEPT1 Is Downregulated During Intestinal Inflammation and Is Not Required for NOD2-dependent Immune Activation.
Colitis
Colonic miRNA expression/secretion, regulated by intestinal epithelial PepT1, plays an important role in cell-to-cell communication during colitis.
Colitis
Critical role of PepT1 in promoting colitis-associated cancer and therapeutic benefits of the anti-inflammatory PepT1-mediated tripeptide KPV in a murine model.
Colitis
Dietary Bioactive Peptide Alanyl-Glutamine Attenuates Dextran Sodium Sulfate-Induced Colitis by Modulating Gut Microbiota.
Colitis
IL-16 induces intestinal inflammation via PepT1 upregulation in a pufferfish model: new insights into the molecular mechanism of inflammatory bowel disease.
Colitis
Impact of PepT1 deletion on microbiota composition and colitis requires multiple generations.
Colitis
MicroRNA-193a-3p Reduces Intestinal Inflammation in Response to Microbiota via Down-regulation of Colonic PepT1.
Colitis
PepT1 expressed in immune cells has an important role in promoting the immune response during experimentally induced colitis.
Colitis, Ulcerative
A PepT1 mediated medicinal nano-system for targeted delivery of cyclosporine A to alleviate acute severe ulcerative colitis.
Colitis, Ulcerative
Inhibitory Potency of Marketed Drugs for Ulcerative Colitis and Crohn's Disease on PEPT1.
Colitis, Ulcerative
MicroRNA-193a-3p Reduces Intestinal Inflammation in Response to Microbiota via Down-regulation of Colonic PepT1.
Colitis, Ulcerative
Peptide Receptor-Targeted Fluorescent Probe: Visualization and Discrimination between Chronic and Acute Ulcerative Colitis.
Colitis, Ulcerative
The peptide transporter PEPT1 is expressed in distal colon in rodents and humans and contributes to water absorption.
Colitis, Ulcerative
Tumor necrosis factor-alpha and interferon-gamma increase PepT1 expression and activity in the human colon carcinoma cell line Caco-2/bbe and in mouse intestine.
Colitis-Associated Neoplasms
Critical role of PepT1 in promoting colitis-associated cancer and therapeutic benefits of the anti-inflammatory PepT1-mediated tripeptide KPV in a murine model.
Colonic Neoplasms
Synthesis of CDDO-Amino Acid-Nitric Oxide Donor Trihybrids as Potential Antitumor Agents against Both Drug-Sensitive and Drug-Resistant Colon Cancer.
Colonic Neoplasms
Transport of the Photodynamic Therapy Agent 5-Aminolevulinic Acid by Distinct H+-Coupled Nutrient Carriers Co-expressed in the Small Intestine.
Colorectal Neoplasms
Critical role of PepT1 in promoting colitis-associated cancer and therapeutic benefits of the anti-inflammatory PepT1-mediated tripeptide KPV in a murine model.
Colorectal Neoplasms
Epigenetic regulation of intestinal peptide transporter PEPT1 as a potential strategy for colorectal cancer sensitization.
Colorectal Neoplasms
[Effects of silencing circRNA ABCB10 expression on biological properties of colorectal cancer cells].
Common Variable Immunodeficiency
Major histocompatibility haplotypes associated with immunoglobulin-A deficiency and common variable immunodeficiency: analysis of the peptide transporter genes TAP1 and TAP2.
Crohn Disease
Inhibitory Potency of Marketed Drugs for Ulcerative Colitis and Crohn's Disease on PEPT1.
Crohn Disease
The peptide transporter PEPT1 is expressed in distal colon in rodents and humans and contributes to water absorption.
Crohn Disease
Tumor necrosis factor-alpha and interferon-gamma increase PepT1 expression and activity in the human colon carcinoma cell line Caco-2/bbe and in mouse intestine.
Cryptosporidiosis
Cryptosporidiosis induces a transient upregulation of the oligopeptides transporter (PepT1) activity in neonatal rats.
Cryptosporidiosis
Evidence for intestinal heterogenic expression of di-tripeptides transporter PepT1 during experimental cryptosporidiosis in neonatal rats.
Cryptosporidiosis
Intestinal peptide transporter PepT1 is over-expressed during acute cryptosporidiosis in suckling rats as a result of both malnutrition and experimental parasite infection.
Cystic Fibrosis
ATP-binding-cassette (ABC) transport systems: functional and structural aspects of the ATP-hydrolyzing subunits/domains.
Cystic Fibrosis
Cryo-EM Visualization of an Active High Open Probability CFTR Anion Channel.
Cystic Fibrosis
Cystic fibrosis transmembrane conductance regulator inverts protein kinase A-mediated regulation of epithelial sodium channel single channel kinetics.
Cystic Fibrosis
Distribution and function of the peptide transporter PEPT2 in normal and cystic fibrosis human lung.
Cystic Fibrosis
Impaired transporter associated with antigen processing (TAP) function attributable to a single amino acid alteration in the peptide TAP subunit TAP1.
Cystic Fibrosis
The cubicon method for concentrating membrane proteins in the cubic mesophase.
Cystic Fibrosis
Volume-regulated chloride channels associated with the human multidrug-resistance P-glycoprotein.
Cystic Fibrosis
[Expression, localization and functional aspects of the peptide transporter PEPT2 in the normal respiratory tract and in cystic fibrosis]
Cystic Fibrosis
[MDR (multidrug resistance) in hepatocarcinoma clinical-therapeutic implications]
Diabetes Mellitus
P-glycoprotein and breast cancer resistance protein expression and function at the blood-brain barrier and blood-cerebrospinal fluid barrier (choroid plexus) in streptozotocin-induced diabetes in rats.
Diabetes Mellitus, Type 1
Gut Microbiota Differs in Composition and Functionality Between Children With Type 1 Diabetes and MODY2 and Healthy Control Subjects: A Case-Control Study.
Diabetes Mellitus, Type 1
Linkage of faulty major histocompatibility complex class I to autoimmune diabetes.
Diabetes Mellitus, Type 1
MHC class I-mediated antigen presentation and induction of CD8+ cytotoxic T-cell responses in autoimmune diabetes-prone NOD mice.
Diabetes Mellitus, Type 1
Protection from insulin-dependent diabetes mellitus is linked to a peptide transporter gene.
Diabetes Mellitus, Type 2
Intestinal absorption of cephalexin in diabetes mellitus model rats.
Drug-Related Side Effects and Adverse Reactions
Targeting PEPT1: a novel strategy to improve the antitumor efficacy of doxorubicin in human hepatocellular carcinoma therapy.
Empyema
Necrotizing pneumonia and empyema in an immunocompetent patient caused by Nocardia cyriacigeorgica and identified by 16S rRNA and secA1 sequencing.
Enteritis
Mechanism of inhibition of proton: dipeptide co-transport during chronic enteritis in the mammalian small intestine.
Epilepsy
Glomerular filtration rate is a major predictor of clearance of oxcarbazepine active metabolite in adult Chinese epileptic patients: A population pharmacokinetic analysis.
Gastrointestinal Neoplasms
Reactive oxygen species involved cancer cellular specific 5-aminolevulinic acid uptake in gastric epithelial cells.
Gastrointestinal Neoplasms
Search for novel target molecules for the effective treatment or prevention of colorectal cancer.
Glioblastoma
The proton-coupled oligopeptide transporters PEPT2, PHT1 and PHT2 mediate the uptake of carnosine in glioblastoma cells.
Glioma
Circ-ABCB10 acts as an oncogene in glioma cells via regulation of the miR-620/FABP5 axis.
Glioma
Identification of PEPT2 as an important candidate molecule in 5-ALA-mediated fluorescence-guided surgery in WHO grade II/III gliomas.
Granuloma
Mycobacterium marinum SecA2 Promotes Stable Granulomas and Induces Tumor Necrosis Factor Alpha In Vivo.
Hepatitis C
Dissimilar expression of multidrug resistance mdr1 and bcrp by the replication of hepatitis C virus: role of the nonstructural 5A protein.
Herpes Simplex
Dipeptide monoester ganciclovir prodrugs for treating HSV-1-induced corneal epithelial and stromal keratitis: in vitro and in vivo evaluations.
Herpes Simplex
The active site of ICP47, a herpes simplex virus-encoded inhibitor of the major histocompatibility complex (MHC)-encoded peptide transporter associated with antigen processing (TAP), maps to the NH2-terminal 35 residues.
HIV Infections
Polymerase chain reaction of secA1 on sputum or oral wash samples for the diagnosis of pulmonary tuberculosis.
Hyperglycemia
ABCB10 exports mitochondrial biliverdin, driving metabolic maladaptation in obesity.
Hypertension
Effect of ageing and hypertension on the expression and activity of PEPT2 in normal and hypertrophic hearts.
Hyperthyroidism
Decreased activity and expression of intestinal oligopeptide transporter PEPT1 in rats with hyperthyroidism in vivo.
Hypoglycemia
Cystic fibrosis transmembrane conductance regulator inverts protein kinase A-mediated regulation of epithelial sodium channel single channel kinetics.
Infections
Alterations in hexose, amino acid and peptide transporter expression in intestinal epithelial cells during Nippostrongylus brasiliensis infection in the rat.
Infections
Analysis of transcriptome sequencing of sciatic nerves in Sprague-Dawley rats of different ages.
Infections
Campylobacter jejuni influences the expression of nutrient transporter genes in the intestine of chickens.
Infections
Effects of fluoroquinolone treatment on MDR1 and MRP2 mRNA expression in Escherichia coli-infected chickens.
Infections
Intestinal peptide transporter PepT1 is over-expressed during acute cryptosporidiosis in suckling rats as a result of both malnutrition and experimental parasite infection.
Infections
Microarray analysis reveals the inhibition of intestinal expression of nutrient transporters in piglets infected with porcine epidemic diarrhea virus.
Infections
Modulation of transporter associated with antigen processing (TAP)-mediated peptide import into the endoplasmic reticulum by flavivirus infection.
Infections
Mycobacterium marinum SecA2 Promotes Stable Granulomas and Induces Tumor Necrosis Factor Alpha In Vivo.
Infections
Recovery of functional peptide transporter PepT1 in budded baculovirus fraction.
Infections
The effect of Eimeria maxima infection on the expression of amino acid and sugar transporters aminopeptidase, as well as the di- and tri-peptide transporter PepT1, is not solely due to decreased feed intake.
Infections
The p60 and NamA autolysins from Listeria monocytogenes contribute to host colonization and induction of protective memory.
Infections
The pathways and mechanisms of muramyl dipeptide transcellular transport mediated by PepT1 in enterogenous infection.
Infections
Xylanase supplementation of a wheat-based diet improved nutrient digestion and mRNA expression of intestinal nutrient transporters in broiler chickens infected with Clostridium perfringens.
Inflammatory Bowel Diseases
Colonic Expression of the Peptide Transporter PEPT1 Is Downregulated During Intestinal Inflammation and Is Not Required for NOD2-dependent Immune Activation.
Inflammatory Bowel Diseases
Function, Regulation, and Pathophysiological Relevance of the POT Superfamily, Specifically PepT1 in Inflammatory Bowel Disease.
Inflammatory Bowel Diseases
IL-16 induces intestinal inflammation via PepT1 upregulation in a pufferfish model: new insights into the molecular mechanism of inflammatory bowel disease.
Inflammatory Bowel Diseases
Inhibitory Potency of Marketed Drugs for Ulcerative Colitis and Crohn's Disease on PEPT1.
Inflammatory Bowel Diseases
PepT1 mediates colon damage by transporting fMLP in rats with bowel resection.
Inflammatory Bowel Diseases
PepT1 mediates transport of the proinflammatory bacterial tripeptide L-Ala-{gamma}-D-Glu-meso-DAP in intestinal epithelial cells.
Inflammatory Bowel Diseases
PepT1 oligopeptide transporter (SLC15A1) gene polymorphism in inflammatory bowel disease.
Inflammatory Bowel Diseases
PepT1-mediated tripeptide KPV uptake reduces intestinal inflammation.
Inflammatory Bowel Diseases
The role and pathophysiological relevance of membrane transporter PepT1 in intestinal inflammation and inflammatory bowel disease.
Insulin Resistance
ABCB10 exports mitochondrial biliverdin, driving metabolic maladaptation in obesity.
Kidney Diseases
A Variant of Peptide Transporter 2 Predicts the Severity of Porphyria-Associated Kidney Disease.
Kidney Failure, Chronic
Determination of renal porphyrin handling in rats suffering from different kinds of chronic renal failure (CRF): uranyl nitrate (UN) induced fibrosis or 5/6-nephrectomy (5/6NX).
Kidney Failure, Chronic
Increased protein level of PEPT1 intestinal H+-peptide cotransporter upregulates absorption of glycylsarcosine and ceftibuten in 5/6 nephrectomized rats.
Kidney Failure, Chronic
Physiological and pharmacological implications of peptide transporters, PEPT1 and PEPT2.
Kidney Failure, Chronic
Upregulation of H(+)-peptide cotransporter PEPT2 in rat remnant kidney.
Kidney Neoplasms
Comprehensive Analysis of the ATP-binding Cassette Subfamily B Across Renal Cancers Identifies ABCB8 Overexpression in Phenotypically Aggressive Clear Cell Renal Cell Carcinoma.
Leprosy
Mycobacterium marinum SecA2 Promotes Stable Granulomas and Induces Tumor Necrosis Factor Alpha In Vivo.
Leukemia, Erythroblastic, Acute
Abcb10 physically interacts with mitoferrin-1 (Slc25a37) to enhance its stability and function in the erythroid mitochondria.
Leukemia, Erythroblastic, Acute
Ferrochelatase forms an oligomeric complex with mitoferrin-1 and Abcb10 for erythroid heme biosynthesis.
Leukemia, Erythroblastic, Acute
Reductions in the mitochondrial ABC transporter Abcb10 affect the transcriptional profile of heme biosynthesis genes.
Leukemia, Myeloid, Acute
Exclusion of ABCB8 and ABCB10 as cancer candidate genes in acute myeloid leukemia.
Liver Diseases
Breast cancer resistance protein (BCRP/ABCG2) is expressed by progenitor cells/reactive ductules and hepatocytes and its expression pattern is influenced by disease etiology and species type: possible functional consequences.
Lung Neoplasms
Circular RNA ABCB10 promotes non-small cell lung cancer progression by increasing E2F5 expression through sponging miR-584-5p.
Lung Neoplasms
Expression of peptide transporter 1?has a positive correlation in protoporphyrin IX accumulation induced by 5-aminolevulinic acid with photodynamic detection of non-small cell lung cancer and metastatic brain tumor specimens originating from non-small cell lung cancer.
Lung Neoplasms
MicroRNA-31 inhibits cisplatin-induced apoptosis in non-small cell lung cancer cells by regulating the drug transporter ABCB9.
Lung Neoplasms
Molecular mechanisms of pulmonary peptidomimetic drug and peptide transport.
Lymphoma
A longitudinal study of ABC transporter expression in canine multicentric lymphoma.
Lymphoma, B-Cell
A longitudinal study of ABC transporter expression in canine multicentric lymphoma.
Malnutrition
Intestinal peptide transporter PepT1 is over-expressed during acute cryptosporidiosis in suckling rats as a result of both malnutrition and experimental parasite infection.
Melanoma
ABCB8 mediates doxorubicin resistance in melanoma cells by protecting the mitochondrial genome.
Melanoma
Constitutive transduction of peptide transporter and HLA genes restores antigen processing function and cytotoxic T cell-mediated immune recognition of human melanoma cells.
Melanoma
Growth Hormone Receptor Knockdown Sensitizes Human Melanoma Cells to Chemotherapy by Attenuating Expression of ABC Drug Efflux Pumps.
Melanoma
Identification of miR-200a-5p targeting the peptide transporter TAP1 and its association with the clinical outcome of melanoma patients.
Melanoma
Involvement of ABC transporters in melanogenesis and the development of multidrug resistance of melanoma.
Melanoma
Mapping ATP-binding cassette transporter gene expression profiles in melanocytes and melanoma cells.
Melanoma
New treatment options for patients with melanoma: review of melanoma-derived T-cell epitope-based peptide vaccines.
Melanoma
Tumor escape from immune recognition: lethal recurrent melanoma in a patient associated with downregulation of the peptide transporter protein TAP-1 and loss of expression of the immunodominant MART-1/Melan-A antigen.
Melanoma
Tumor escape from immune recognition: loss of HLA-A2 melanoma cell surface expression is associated with a complex rearrangement of the short arm of chromosome 6.
Melanoma, Experimental
Characterization of the major histocompatibility complex class I deficiencies in B16 melanoma cells.
Neoplasms
9-Deazapurines as Broad-Spectrum Inhibitors of the ABC Transport Proteins P-Glycoprotein, Multidrug Resistance-Associated Protein 1, and Breast Cancer Resistance Protein.
Neoplasms
A longitudinal study of ABC transporter expression in canine multicentric lymphoma.
Neoplasms
A novel category of antigens enabling CTL immunity to tumor escape variants: Cinderella antigens.
Neoplasms
Anticancer gold(III) peptidomimetics: from synthesis to in vitro and ex vivo biological evaluation.
Neoplasms
Application of an LC-MS/MS method for the simultaneous quantification of human intestinal transporter proteins absolute abundance using a QconCAT technique.
Neoplasms
Atorvastatin synergizes with IFN-? in treating human non-small cell lung carcinomas via potent inhibition of RhoA activity.
Neoplasms
ATP binding cassette subfamily B member 9 (ABCB9) is a prognostic indicator of overall survival in ovarian cancer.
Neoplasms
Boron delivery for boron neutron capture therapy targeting a cancer-upregulated oligopeptide transporter.
Neoplasms
Cancer Detection Using a PET Tracer, 11C-Glycylsarcosine, Targeted to H+/Peptide Transporter.
Neoplasms
Carrier-mediated transport of oligopeptides in the human fibrosarcoma cell line HT1080.
Neoplasms
CD8+ T Cell Responses against TAP-Inhibited Cells Are Readily Detected in the Human Population.
Neoplasms
Chorioamnionitis Induces a Specific Signature of Placental ABC Transporters Associated with an Increase of miR-331-5p in the Human Preterm Placenta.
Neoplasms
Circular RNA ABCB10 promotes tumor progression and correlates with pejorative prognosis in clear cell renal cell carcinoma.
Neoplasms
Class I processing-defective Burkitt's lymphoma cells are recognized efficiently by CD4+ EBV-specific CTLs.
Neoplasms
Constitutive transduction of peptide transporter and HLA genes restores antigen processing function and cytotoxic T cell-mediated immune recognition of human melanoma cells.
Neoplasms
Coordinate downregulation of multiple MHC class I antigen processing genes in chemical-induced murine tumor cell lines of distinct origin.
Neoplasms
Critical role of PepT1 in promoting colitis-associated cancer and therapeutic benefits of the anti-inflammatory PepT1-mediated tripeptide KPV in a murine model.
Neoplasms
Delta-aminolevulinic acid transport in cancer cells of the human extrahepatic biliary duct.
Neoplasms
Dominant contribution of the proteasome and metalloproteinases to TAP-independent MHC-I peptide repertoire.
Neoplasms
Dormant cancer cells accumulate high protoporphyrin IX levels and are sensitive to 5-aminolevulinic acid-based photodynamic therapy.
Neoplasms
Downregulation of the constitutive tapasin expression in human tumor cells of distinct origin and its transcriptional upregulation by cytokines.
Neoplasms
Enhanced cancer cell growth inhibition by dipeptide prodrugs of floxuridine: increased transporter affinity and metabolic stability.
Neoplasms
Eugenol attenuates inflammatory response and enhances barrier function during lipopolysaccharide-induced inflammation in the porcine intestinal epithelial cells.
Neoplasms
Exclusion of ABCB8 and ABCB10 as cancer candidate genes in acute myeloid leukemia.
Neoplasms
Functional deficiencies of components of the MHC class I antigen pathway in human tumors of epithelial origin.
Neoplasms
Gene expression profiling of ATP-binding cassette (ABC) transporters as a predictor of the pathologic response to neoadjuvant chemotherapy in breast cancer patients.
Neoplasms
Identification of miR-200a-5p targeting the peptide transporter TAP1 and its association with the clinical outcome of melanoma patients.
Neoplasms
Impact of PepT1 deletion on microbiota composition and colitis requires multiple generations.
Neoplasms
Induction of protective CTL immunity against peptide transporter TAP-deficient tumors through dendritic cell vaccination.
Neoplasms
Modulation of antigen processing and presentation by persistent virus infections and in tumors.
Neoplasms
Mycobacterium marinum SecA2 Promotes Stable Granulomas and Induces Tumor Necrosis Factor Alpha In Vivo.
Neoplasms
New treatment options for patients with melanoma: review of melanoma-derived T-cell epitope-based peptide vaccines.
Neoplasms
Peptide transporter (TAP-1 and TAP-2)-independent endogenous processing of Epstein-Barr virus (EBV) latent membrane protein 2A: implications for cytotoxic T-lymphocyte control of EBV-associated malignancies.
Neoplasms
Rational design of gold(III)-dithiocarbamato peptidomimetics for the targeted anticancer chemotherapy.
Neoplasms
Reactive oxygen species involved cancer cellular specific 5-aminolevulinic acid uptake in gastric epithelial cells.
Neoplasms
Search for novel target molecules for the effective treatment or prevention of colorectal cancer.
Neoplasms
Specific expression of proton-coupled oligopeptide transporter 1 in primary hepatocarcinoma-a novel strategy for tumor-targeted therapy.
Neoplasms
Spontaneous resistance to acute T-cell leukaemias in TCRV gamma 1.1J gamma 4C gamma 4 transgenic mice.
Neoplasms
Study of the mechanisms of uptake of 5-aminolevulinic acid derivatives by PEPT1 and PEPT2 transporters as a tool to improve photodynamic therapy of tumours.
Neoplasms
Subacute toxicity of mesoporous silica nanoparticles to the intestinal tract and the underlying mechanism.
Neoplasms
Targeted delivery to PEPT1-overexpressing cells: acidic, basic, and secondary floxuridine amino acid ester prodrugs.
Neoplasms
Targeting PEPT1: a novel strategy to improve the antitumor efficacy of doxorubicin in human hepatocellular carcinoma therapy.
Neoplasms
Taxane-based reversal agents modulate drug resistance mediated by P-glycoprotein, multidrug resistance protein, and breast cancer resistance protein.
Neoplasms
The Cisplatin-Derived Increase of Mitochondrial Reactive Oxygen Species Enhances the Effectiveness of Photodynamic Therapy via Transporter Regulation.
Neoplasms
The Immunogenicity of a Proline-Substituted Altered Peptide Ligand toward the Cancer-Associated TEIPP Neoepitope Trh4 Is Unrelated to Complex Stability.
Neoplasms
The proton-coupled oligopeptide transporters PEPT2, PHT1 and PHT2 mediate the uptake of carnosine in glioblastoma cells.
Neoplasms
The role of solute carrier (SLC) transporters in actinomycin D pharmacokinetics in paediatric cancer patients.
Neoplasms
The varicellovirus-encoded TAP inhibitor UL49.5 regulates the presentation of CTL epitopes by Qa-1b1.
Neoplasms
Thymol improves barrier function and attenuates inflammatory responses in porcine intestinal epithelial cells during lipopolysaccharide (LPS)-induced inflammation.
Neoplasms
Toward the selective delivery of chemotherapeutics into tumor cells by targeting Peptide transporters: tailored gold-based anticancer peptidomimetics.
Neoplasms
Transport of the Photodynamic Therapy Agent 5-Aminolevulinic Acid by Distinct H+-Coupled Nutrient Carriers Co-expressed in the Small Intestine.
Neoplasms
Tumor escape from immune recognition: lethal recurrent melanoma in a patient associated with downregulation of the peptide transporter protein TAP-1 and loss of expression of the immunodominant MART-1/Melan-A antigen.
Neoplasms
Tumor necrosis factor-alpha and interferon-gamma increase PepT1 expression and activity in the human colon carcinoma cell line Caco-2/bbe and in mouse intestine.
Neoplasms
Upregulation of Breast Cancer Resistance Protein Expression was Decreased in Plasma Membrane of Colon Cancer with Metastasis of Lymphatic Node.
Neoplasms
Vaccination against Nonmutated Neoantigens Induced in Recurrent and Future Tumors.
Neoplasms
Variation of peptide transporter (PepT1 and HPT1) expression in Caco-2 cells as a function of cell origin.
Nocardia Infections
Nocardia thailandica Pulmonary Nocardiosis in a Post-Solid Organ Transplant Patient.
Obesity
ABCB10 exports mitochondrial biliverdin, driving metabolic maladaptation in obesity.
Obesity
Association between polymorphisms in SLC15A1 and PLA2G16 genes and development of obesity in Chinese subjects.
Obesity
Disturbed intestinal nitrogen homeostasis in a mouse model of high-fat diet-induced obesity and glucose intolerance.
Obesity
How the intestinal peptide transporter PEPT-1 contributes to an obesity phenotype in Caenorhabditits elegans.
Obesity
Long-term effect of leptin on H+-coupled peptide cotransporter 1 activity and expression in vivo: evidence in leptin-deficient mice.
Obesity
Mice lacking the intestinal peptide transporter display reduced energy intake and a subtle maldigestion/-absorption that protects them from diet-induced obesity.
Obesity
Reduced intestinal absorption of dipeptides via PepT1 in mice with diet-induced obesity is associated with leptin receptor down-regulation.
Obesity
Rosiglitazone and Metformin Have Opposite Effects on Intestinal Absorption of Oligopeptides via the Proton-Dependent PepT1 Transporter.
Osteosarcoma
Endosialin?expressing bone sarcoma stem?like cells are highly tumor?initiating and invasive.
Ovarian Neoplasms
ATP binding cassette subfamily B member 9 (ABCB9) is a prognostic indicator of overall survival in ovarian cancer.
Pancreatic Neoplasms
Drug efflux transporter MRP5 affects sensitivity of pancreatic cancer cell lines to the nucleoside anticancer drug 5-fluorouracil.
Pancreatic Neoplasms
Viral envelope protein gp64 transgenic mouse facilitates the generation of monoclonal antibodies against exogenous membrane proteins displayed on baculovirus.
Pancreatitis
Characterization of immunoreactive trypsinogen activation peptide in urine in acute pancreatitis.
Parasitic Diseases
Intestinal peptide transporter PepT1 is over-expressed during acute cryptosporidiosis in suckling rats as a result of both malnutrition and experimental parasite infection.
Peritonitis
Gordonia species as emerging causes of continuous-ambulatory-peritoneal-dialysis-related peritonitis identified by 16S rRNA and secA1 gene sequencing and matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS).
Pneumonia, Necrotizing
Necrotizing pneumonia and empyema in an immunocompetent patient caused by Nocardia cyriacigeorgica and identified by 16S rRNA and secA1 sequencing.
Porcine Reproductive and Respiratory Syndrome
The bacterial peptidoglycan-sensing molecule Pglyrp2 modulates brain development and behavior.
Porphyrias, Hepatic
Peptide transporter 2 (PEPT2) expression in brain protects against 5-aminolevulinic acid neurotoxicity.
Protein Deficiency
Board-invited review: Peptide absorption and utilization: Implications for animal nutrition and health.
Protoporphyria, Erythropoietic
Abcb10 role in heme biosynthesis in vivo: Abcb10 knockout in mice causes anemia with protoporphyrin IX and iron accumulation.
Pulmonary Fibrosis
[Expression of PEPT2 mRNA in lung tissue of rats with pulmonary fibrosis].
Renal Insufficiency
Dietary Inorganic Phosphorus Regulates the Intestinal Peptide Transporter PepT1.
Renal Insufficiency
Increased protein level of PEPT1 intestinal H+-peptide cotransporter upregulates absorption of glycylsarcosine and ceftibuten in 5/6 nephrectomized rats.
Sepsis
Catheter-related bloodstream infection due to Tsukamurella pulmonis identified by MALDI-TOF spectrometry, 16S rRNA gene sequencing, and secA1 gene sequencing in an immunocompromised child: a case report and literature review.
Sepsis
Ghrelin upregulates PepT1 activity in the small intestine epithelium of rats with sepsis.
Squamous Cell Carcinoma of Head and Neck
Circular RNA ABCB10 contributes to laryngeal squamous cell carcinoma (LSCC) progression by modulating the miR-588/CXCR4 axis.
Squamous Cell Carcinoma of Head and Neck
Defects in the human leukocyte antigen class I antigen processing machinery in head and neck squamous cell carcinoma: association with clinical outcome.
Staphylococcal Infections
Analysis of transcriptome sequencing of sciatic nerves in Sprague-Dawley rats of different ages.
Starvation
A novel mechanism for the biogenesis of outer membrane vesicles in Gram-negative bacteria.
Starvation
CsrA regulates translation of the Escherichia coli carbon starvation gene, cstA, by blocking ribosome access to the cstA transcript.
Starvation
Induction of intestinal peptide transporter 1 expression during fasting is mediated via peroxisome proliferator-activated receptor alpha.
Starvation
PepT1 mRNA expression is induced by starvation and its level correlates with absorptive transport of cefadroxil longitudinally in the rat intestine.
Starvation
Peptide transporter in the rat small intestine: ultrastructural localization and the effect of starvation and administration of amino acids.
Starvation
Peptide transporter YjiY influences the expression of the virulence gene mgtC to regulate biofilm formation in Salmonella.
Starvation
Regulation of the pstSCAB operon in Corynebacterium glutamicum by the regulator of acetate metabolism RamB.
Stomach Neoplasms
Pivotal roles of peptide transporter PEPT1 and ATP-binding cassette (ABC) transporter ABCG2 in 5-aminolevulinic acid (ALA)-based photocytotoxicity of gastric cancer cells in vitro.
Stomach Neoplasms
Regulation of human peptide transporter 1 (PEPT1) in gastric cancer cells by anticancer drugs.
Stomach Neoplasms
The Cisplatin-Derived Increase of Mitochondrial Reactive Oxygen Species Enhances the Effectiveness of Photodynamic Therapy via Transporter Regulation.
Stomach Neoplasms
Upregulation of Breast Cancer Resistance Protein Expression was Decreased in Plasma Membrane of Colon Cancer with Metastasis of Lymphatic Node.
Stroke
Isolation of peptide transport system-6 from brain endothelial cells: therapeutic effects with antisense inhibition in Alzheimer and stroke models.
Stroke
Molecular Disruption of the Power Stroke in the ATP-binding Cassette Transport Protein MsbA.
Stroke
Protease protection assays show polypeptide movement into the SecY channel by power strokes of the SecA ATPase.
Tuberculosis
A method to investigate protein association with intact sealed mycobacterial membrane vesicles.
Tuberculosis
ADP-dependent conformational changes distinguish Mycobacterium tuberculosis SecA2 from SecA1.
Tuberculosis
ATPase activity of Mycobacterium tuberculosis SecA1 and SecA2 proteins and its importance for SecA2 function in macrophages.
Tuberculosis
Cloning, expression, and functional characterization of the Mycobacterium tuberculosis secA gene.
Tuberculosis
Conservation of the binding site for the arginine repressor in all bacterial lineages.
Tuberculosis
Crystal structure of Mycobacterium tuberculosis SecA, a preprotein translocating ATPase.
Tuberculosis
Enhanced priming of adaptive immunity by a proapoptotic mutant of Mycobacterium tuberculosis.
Tuberculosis
Identification and characterization of metal uptake ABC transporters in Mycobacterium tuberculosis unveil their ligand specificity.
Tuberculosis
Identification of two Mycobacterium smegmatis lipoproteins exported by a SecA2-dependent pathway.
Tuberculosis
In Vitro Interaction of the Housekeeping SecA1 with the Accessory SecA2 Protein of Mycobacterium tuberculosis.
Tuberculosis
Label-free Quantitative Proteomics Reveals a Role for the Mycobacterium tuberculosis SecA2 Pathway in Exporting Solute Binding Proteins and Mce Transporters to the Cell Wall.
Tuberculosis
Lysine auxotrophy combined with deletion of the SecA2 gene results in a safe and highly immunogenic candidate live attenuated vaccine for tuberculosis.
Tuberculosis
Mycobacterium marinum SecA2 Promotes Stable Granulomas and Induces Tumor Necrosis Factor Alpha In Vivo.
Tuberculosis
Mycobacterium tuberculosis exploits host ATM kinase for survival advantage through SecA2 secretome.
Tuberculosis
Mycobacterium tuberculosis isolate with a distinct genomic identity overexpresses a tap-like efflux pump.
Tuberculosis
Mycobacterium tuberculosis SatS is a chaperone for the SecA2 protein export pathway.
Tuberculosis
Mycobacterium tuberculosis-induced IFN-? production requires cytosolic DNA and RNA sensing pathways.
Tuberculosis
Optimization of Thiazolidone Scaffolds Using Pocket Modeling for Development of Potential Secretory System Inhibitors of Mycobacterium tuberculosis.
Tuberculosis
Polymerase chain reaction of secA1 on sputum or oral wash samples for the diagnosis of pulmonary tuberculosis.
Tuberculosis
Priming of protective anti-Listeria memory CD8+ T cell requires a functional SecA2-secretion system.
Tuberculosis
Protein export by the mycobacterial SecA2 system is determined by the preprotein mature domain.
Tuberculosis
SecA2 functions in the secretion of superoxide dismutase A and in the virulence of Mycobacterium tuberculosis.
Tuberculosis
Structural Similarities and Differences between Two Functionally Distinct SecA Proteins, Mycobacterium tuberculosis SecA1 and SecA2.
Tuberculosis
The Accessory SecA2 System of Mycobacteria Requires ATP Binding and the Canonical SecA1.
Tuberculosis
The Mycobacterium tuberculosis SecA2 System Subverts Phagosome Maturation To Promote Growth in Macrophages.
Tuberculosis
The SecA2 pathway of Mycobacterium tuberculosis exports effectors that work in concert to arrest phagosome and autophagosome maturation.
Tuberculosis
The SecA2 secretion factor of Mycobacterium tuberculosis promotes growth in macrophages and inhibits the host immune response.
Tuberculosis
[Recent progress in taxonomic studies on pathogenic nocardia and usefulness of the bacteria for the studies on secondary metabolites and antibiotic resistant mechanisms].
Tuberculosis, Pulmonary
Polymerase chain reaction of secA1 on sputum or oral wash samples for the diagnosis of pulmonary tuberculosis.
Urinary Bladder Neoplasms
Expression levels of PEPT1 and ABCG2 play key roles in 5-aminolevulinic acid (ALA)-induced tumor-specific protoporphyrin IX (PpIX) accumulation in bladder cancer.
Urinary Bladder Neoplasms
Expression of ferrochelatase has a strong correlation in protoporphyrin IX accumulation with photodynamic detection of bladder cancer.
Urinary Bladder Neoplasms
Systemic transduction of p16INK4A antitumor peptide inhibits the growth of MBT-2 mouse bladder tumor cell line grafts.
Vesicular Stomatitis
MHC class I heavy chain-dependent expression of discontinuous antigenic epitopes on beta 2-microglobulinb is inducible with peptide-ligand.
Virus Diseases
Induction of the rainbow trout MHC class I pathway during acute IHNV infection.
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ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY
GeneOntology No.
LITERATURE
SOURCE
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UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable).
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MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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SUBUNIT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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CRYSTALLIZATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
extracellular domain from isoform PepT2, sitting drop vapor diffusion method, using 0.2 M (NH4)3 citrate (pH 5.8) and 21% PEG (w/v) 3350
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Beale, J.H.; Parker, J.L.; Samsudin, F.; Barrett, A.L.; Senan, A.; Bird, L.E.; Scott, D.; Owens, R.J.; Sansom, M.S.; Tucker, S.J.; Meredith, D.; Fowler, P.W.; Newstead, S.
Crystal structures of the extracellular domain from PepT1 and PepT2 provide novel insights into mammalian peptide transport
Structure
23
1889-1899
2015
Rattus norvegicus (Q63424), Mus musculus (Q9JIP7)
brenda
EXTERNAL LINKS (specific for EC-Number 7.4.2.5)
Transporter Classification Database (TCDB): 3.A.1.109.8
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
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