An ATP-binding cassette (ABC) type transporter, characterized by the presence of two similar ATP-binding domains/proteins and two integral membrane domains/proteins. The enzyme, found in Clostridioides, interacts with an extracytoplasmic substrate binding lipoprotein and mediates the import of L-tyrosine. L-phenylalanine is also tranported however with lower efficiency.
The expected taxonomic range for this enzyme is: Clostridioides difficile
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SYSTEMATIC NAME
IUBMB Comments
ATP phosphohydrolase (ABC-type, L-tyrosine-importing)
An ATP-binding cassette (ABC) type transporter, characterized by the presence of two similar ATP-binding domains/proteins and two integral membrane domains/proteins. The enzyme, found in Clostridioides, interacts with an extracytoplasmic substrate binding lipoprotein and mediates the import of L-tyrosine. L-phenylalanine is also tranported however with lower efficiency.
the loss of genes encoding the substrate-binding protein and the ATP-binding protein is strongly associated with the reduced uptake of tyrosine and production of derived Stickland fermentation products, including p-cresol
the loss of genes encoding the substrate-binding protein and the ATP-binding protein is strongly associated with the reduced uptake of tyrosine and production of derived Stickland fermentation products, including p-cresol
frequent, convergent loss of genes encoding the substrate-binding protein and the ATP-binding protein of an ATP-binding cassette (ABC) transporter from the genomes of unrelated Clostridioides difficile strains. The genomic deletion is strongly associated with the reduced uptake of tyrosine and phenylalanine and production of derived Stickland fermentation products, including p-cresol. The transporter gene loss does not measurably affect bacterial growth or production of enterotoxins. The gene deletion has occurred multiple times in diverse clonal lineages of Clostridioides difficile, with a particularly high prevalence in ribotype 027 isolates
frequent, convergent loss of genes encoding the substrate-binding protein and the ATP-binding protein of an ATP-binding cassette (ABC) transporter from the genomes of unrelated Clostridioides difficile strains. The genomic deletion is strongly associated with the reduced uptake of tyrosine and phenylalanine and production of derived Stickland fermentation products, including p-cresol. The transporter gene loss does not measurably affect bacterial growth or production of enterotoxins. The gene deletion has occurred multiple times in diverse clonal lineages of Clostridioides difficile, with a particularly high prevalence in ribotype 027 isolates
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