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Information on EC 7.4.2.12 - ABC-type cystine transporter

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EC Tree
IUBMB Comments
ABC-type (ATP-binding cassette-type) transporter, characterized by the presence of two similar ATP-binding domains/proteins and two integral membrane domains/proteins. A bacterial enzyme that interacts with an extracytoplasmic substrate binding protein and mediates the high affinity import of trace cystine. The enzyme from Escherichia coli K-12 can import both isomers of cystine and a variety of related molecules including djenkolate, lanthionine, diaminopimelate and homocystine.
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UNIPROT: C6XGT2
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Word Map
The enzyme appears in viruses and cellular organisms
Reaction Schemes
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L-cystine-[cystine-binding protein][side 1]
=
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+
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[cystine-binding protein][side 1]
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+
D-cystine-[cystine-binding protein][side 1]
=
+
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[cystine-binding protein][side 1]
Synonyms
tcyabc, l-cystine transporter, cystine importer, fliy-yecsc, l-cystine abc transporter, ytmjklmn, yckkji, cystine abc transporter, tcyjln, tcyjklmn, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
L-cystine ABC transporter
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cystine ABC transporter
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cystine transporting ATPase
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SYSTEMATIC NAME
IUBMB Comments
ATP phosphohydrolase (ABC-type, cystine-importing)
ABC-type (ATP-binding cassette-type) transporter, characterized by the presence of two similar ATP-binding domains/proteins and two integral membrane domains/proteins. A bacterial enzyme that interacts with an extracytoplasmic substrate binding protein and mediates the high affinity import of trace cystine. The enzyme from Escherichia coli K-12 can import both isomers of cystine and a variety of related molecules including djenkolate, lanthionine, diaminopimelate and homocystine.
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
ATP + H2O + D-cystine-[cystine-binding protein](side 1)
ADP + phosphate + D-cystine(side 2) + [cystine-binding protein](side 1)
show the reaction diagram
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-
?
ATP + H2O + L-cystine-[cystine-binding protein](side 1)
ADP + phosphate + L-cystine(side 2) + [cystine-binding protein](side 1)
show the reaction diagram
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?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
ATP + H2O + D-cystine-[cystine-binding protein](side 1)
ADP + phosphate + D-cystine(side 2) + [cystine-binding protein](side 1)
show the reaction diagram
-
-
-
?
ATP + H2O + L-cystine-[cystine-binding protein](side 1)
ADP + phosphate + L-cystine(side 2) + [cystine-binding protein](side 1)
show the reaction diagram
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-
-
?
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
C6XGT2_LIBAP
Liberibacter asiaticus (strain psy62)
274
0
31845
TrEMBL
-
CRYSTALLIZATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
enzyme complex with L-cystine, L-cysteine, L-arginine and citrate, sitting drop vapor diffusion method, using 0.1 M sodium acetate trihydrate buffer, pH 5.6 containing 2.0 M ammonium sulfate
PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
His-Select nickel affinity column chromatography and Superdex S200 gel filtration
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
expressed in Escherichia coli Rosetta (DE3) cells
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Kumar, P.; Kesari, P.; Kokane, S.; Ghosh, D.K.; Kumar, P.; Sharma, A.K.
Crystal structures of a putative periplasmic cystine-binding protein from Candidatus Liberibacter asiaticus insights into an adapted mechanism of ligand binding
FEBS J.
286
3450-3472
2019
Candidatus Liberibacter asiaticus (C6XGT2), Candidatus Liberibacter asiaticus, Candidatus Liberibacter asiaticus psy62 (C6XGT2)
Manually annotated by BRENDA team