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Information on EC 7.4.2.10 - ABC-type glutathione transporter

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EC Tree
IUBMB Comments
A prokaryotic ATP-binding cassette (ABC) type transporter, characterized by the presence of two similar ATP-binding domains/proteins and two integral membrane domains/proteins. The enzyme from the bacterium Escherichia coli is a heterotrimeric complex that interacts with an extracytoplasmic substrate binding protein to mediate the uptake of glutathione.
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This record set is specific for:
UNIPROT: P75798
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The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Reaction Schemes
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glutathione-[glutathione-binding protein][side 1]
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[glutathione-binding protein][side 1]
Synonyms
multidrug resistance associated protein 1, moat3, mrp-like protein, abcc3-type transporter, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
glutathione ABC transporter
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glutathione transporting ATPase
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gsiACD
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SYSTEMATIC NAME
IUBMB Comments
ATP phosphohydrolase (ABC-type,glutathione-importing)
A prokaryotic ATP-binding cassette (ABC) type transporter, characterized by the presence of two similar ATP-binding domains/proteins and two integral membrane domains/proteins. The enzyme from the bacterium Escherichia coli is a heterotrimeric complex that interacts with an extracytoplasmic substrate binding protein to mediate the uptake of glutathione.
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
ATP + H2O + glutathione-[glutathione-binding protein][side 1]
ADP + phosphate + glutathione[side 2] + [glutathione-binding protein][side 1]
show the reaction diagram
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-
?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
ATP + H2O + glutathione-[glutathione-binding protein][side 1]
ADP + phosphate + glutathione[side 2] + [glutathione-binding protein][side 1]
show the reaction diagram
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-
-
?
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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UniProt
Manually annotated by BRENDA team
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
integral membrane protein
Manually annotated by BRENDA team
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
GSIC_ECOLI
Escherichia coli (strain K12)
306
0
34066
Swiss-Prot
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Moussatova, A.; Kandt, C.; O'Mara, M.; Tieleman, D.
ATP-binding cassette transporters in Escherichia coli
Biochim. Biophys. Acta
1778
1757-1771
2008
Escherichia coli (P75796), Escherichia coli (P75797), Escherichia coli (P75798), Escherichia coli (P75799)
Manually annotated by BRENDA team