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Information on EC 7.4.2.1 - ABC-type polar-amino-acid transporter
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7.4.2.1 ABC-type polar-amino-acid transporterIUBMB Comments
An ATP-binding cassette (ABC) type transporter, characterized by the presence of two similar ATP-binding domains/proteins and two integral membrane domains/proteins. The enzyme, found in bacteria, interacts with an extracytoplasmic substrate binding protein and mediates the import of polar amino acids. This entry comprises bacterial enzymes that import His, Arg, Lys, Glu, Gln, Asp, ornithine, octopine and nopaline.
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Word Map
- 7.4.2.1
-
excitatory
-
l-type
- oocytes
- synaptic
- xenopus
- astrocyte
- l-arginine
- na+
-
neurotransmitter
- glial
-
glutamatergic
- vesicular
-
eaats
- rapamycin
- laevis
- slc7a5
-
blood-brain
-
basolateral
-
mtorc1
-
excitotoxicity
-
na+-independent
-
intolerance
- cystine
-
cotransporter
- l-glutamate
- l-leucine
-
gabaergic
- l-lysine
-
neurotransmission
-
ecotropic
-
sodium-coupled
- l-proline
-
sodium-independent
-
proton-coupled
-
monocarboxylate
-
dibasic
-
antiporter
-
electrogenic
-
two-electrode
-
symporter
-
transporter-1
-
transporter-mediated
-
na+-coupled
- proteinosis
-
vglut1
-
glycinergic
- medicine
- l-arg
-
inward-facing
-
microvillous
- rsp5
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Reaction Schemes
+
+
=
+
+
+
+
+
polar amino acid-[polar amino acid-binding protein][side 1]
=
+
+
polar amino acid[side 2]
+
[polar amino acid-binding protein][side 1]
Synonyms
amino acid transporter, slc7a7, amino acid permease, general amino acid permease, gap1p, slc7a1, slc6a19, histidine permease, glnpq, amino acid/auxin permease, 
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
AAP
AAP1
aap3
AAP7
ABC-type transporter for polar amino acids
amino acid permease
amino acid permease 1
amino acid permease 3
ATP phosphohydrolase (polar-amino-acid-importing
-
-
-
-
ATP-binding-cassette type transporter for polar amino acids
BcaP
branched-chain amino acid permease
CTRA
DmeA
EC 3.6.3.21
-
-
formerly
-
FFUJ_09118
GAP1
general amino acid permease
GlnPQ
Hip1
HisP
histidine permease
LHT1
lysine histidine transporter 1
lysine permease
lysine-specific permease
PcGap1
polar-amino-acid-transporting ATPase
-
-
-
-
additional information
-
displays also EC 3.6.3.21 /nonpolar-amino-acid-transporting ATPase activity
ATP-binding-cassette type transporter for polar amino acids
-
-
general amino acid permease
-
catalyzes the transport of all the D- and L-isomers of the amino acids normally found in proteins
HisP
-
-
-
-
histidine permease
-
-
-
-
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
ATP + H2O + polar amino acid-[polar amino acid-binding protein][side 1] = ADP + phosphate + polar amino acid[side 2] + [polar amino acid-binding protein][side 1]
-
-
-
-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
hydroloysis of phosphoric ester
hydrolysis of phosphoric ester
-
-
-
-
transmembrane transport
-
-
-
-
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SYSTEMATIC NAME
IUBMB Comments
ATP phosphohydrolase (ABC-type, polar-amino-acid-importing)
An ATP-binding cassette (ABC) type transporter, characterized by the presence of two similar ATP-binding domains/proteins and two integral membrane domains/proteins. The enzyme, found in bacteria, interacts with an extracytoplasmic substrate binding protein and mediates the import of polar amino acids. This entry comprises bacterial enzymes that import His, Arg, Lys, Glu, Gln, Asp, ornithine, octopine and nopaline.
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CAS REGISTRY NUMBER
COMMENTARY
9000-83-3
-
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
ATP + H2O + acidic amino acid/out
ADP + phosphate + acidic amino acid/in
-
crucial role for the uptake of amino acids into the endosperm and supplying the developing embryo with amino acids during early embryogenesis
-
-
?
ATP + H2O + alpha-aminoadipic acid-[polar amino acid-binding protein][side 1]
ADP + phosphate + alpha-aminoadipic acid[side 2] + [polar amino acid-binding protein][side 1]
ATP + H2O + alpha-aminoisobutyric acid/out
ADP + phosphate + alpha-aminoisobutyric acid/in
-
-
-
-
?
ATP + H2O + citrulline/out
ADP + phosphate + citrulline/in
-
-
-
-
?
ATP + H2O + L-arginine-[L-arginine -binding protein][side 1]
ADP + phosphate + L-arginine[side 2] + [L-arginine-binding protein][side 1]
-
-
-
?
ATP + H2O + L-arginine-[L-arginine-binding protein][side 1]
ADP + phosphate + L-arginine[side 2] + [L-arginine-binding protein][side 1]
ATP + H2O + L-arginine/out
ADP + phosphate + L-arginine/in
-
-
-
-
?
ATP + H2O + L-asparagine-[L-asparagine-binding protein][side 1]
ADP + phosphate + L-asparagine[side 2] + [L-asparagine-binding protein][side 1]
ATP + H2O + L-aspartate-[L-aspartate-binding protein][side 1]
ADP + phosphate + L-aspartate[side 2] + [L-aspartate-binding protein][side 1]
-
-
-
?
ATP + H2O + L-citrulline-[L-citrulline-binding protein][side 1]
ADP + phosphate + L-citrulline[side 2] + [L-citrulline-binding protein][side 1]
-
-
-
?
ATP + H2O + L-citrulline/out
ADP + phosphate + L-citrulline/in
-
-
-
-
?
ATP + H2O + L-glutamate-[L-glutamate-binding protein][side 1]
ADP + phosphate + L-glutamate[side 2] + [L-glutamate-binding protein][side 1]
ATP + H2O + L-glutamic acid-[L-glutamic acid-binding protein][side 1]
ADP + phosphate + L-glutamic acid[side 2] + [L-glutamic acid-binding protein][side 1]
ATP + H2O + L-glutamine-[L-glutamine-binding protein][side 1]
ADP + phosphate + L-glutamine[side 2] + [L-glutamine-binding protein][side 1]
ATP + H2O + L-histidine-[L-histidine-binding protein][side 1]
ADP + phosphate + L-histidine[side 2] + [L-histidine-binding protein][side 1]
ATP + H2O + L-lysine-[L-lysine-binding protein][side 1]
ADP + phosphate + L-lysine[side 2] + [L-lysine-binding protein][side 1]
-
-
-
?
ATP + H2O + L-Orn/out
ADP + phosphate + L-Orn/in
-
the histidine-binding protein HisJ binds L-His and L-Arg tightly and L-Lys and L-Orn less tightly
-
?
ATP + H2O + L-ornithine-[L-ornithine-binding protein][side 1]
ADP + phosphate + L-ornithine[side 2] + [L-ornithine-binding protein][side 1]
-
-
-
?
ATP + H2O + L-phenylalanine/out
ADP + phosphate + L-phenylalanine/in
-
-
-
-
?
ATP + H2O + L-threonine/out
ADP + phosphate + L-threonine/in
-
-
-
-
?
ATP + H2O + neutral amino acid/out
ADP + phosphate + neutral amino acid/in
-
-
-
-
?
ATP + H2O + polar amino acid-[polar amino acid-binding protein][side 1]
ADP + phosphate + polar amino acid[side 2] + [polar amino acid-binding protein][side 1]
-
-
-
-
?
CTP + H2O + His/out
CDP + phosphate + His/in
-
dimeric HisP protein with a carboxy-terminal extension of 8 amino acids, 50% of the ATPase activity with ATP
-
?
GTP + H2O + His/out
GDP + phosphate + His/in
-
dimeric HisP protein with a carboxy-terminal extension of 8 amino acids, 53% of the ATPase activity with ATP
-
?
UTP + H2O + His/out
UDP + phosphate + His/in
-
dimeric HisP protein with a carboxy-terminal extension of 8 amino acids, 37% of the ATPase activity with ATP
-
?
ATP + H2O + alpha-aminoadipic acid-[polar amino acid-binding protein][side 1]
ADP + phosphate + alpha-aminoadipic acid[side 2] + [polar amino acid-binding protein][side 1]
-
-
-
-
?
ATP + H2O + alpha-aminoadipic acid-[polar amino acid-binding protein][side 1]
ADP + phosphate + alpha-aminoadipic acid[side 2] + [polar amino acid-binding protein][side 1]
-
-
-
-
?
ATP + H2O + amino acid/out
ADP + phosphate + amino acid/in
-
acidic and neutral polar amino acid uptake, essential for diazotropic physiology of the bacterium, transports Asp, Glu, Asn, Gln, Met, Thr, Ala, Ser, Gly, and His
-
-
?
ATP + H2O + amino acid/out
ADP + phosphate + amino acid/in
-
essential for basic amino acid uptake, transports Lys, Arg, Orn, His, and Gln
-
-
?
ATP + H2O + amino acid/out
ADP + phosphate + amino acid/in
-
amino acid uptake, catalyzes the transport of all the D- and L-isomers of the amino acids normally found in proteins
-
-
?
ATP + H2O + betaine/out
ADP + phosphate + betaine/in
-
the histidine transport system Hut is also involved in proline and betaine uptake
-
?
ATP + H2O + His/out
ADP + phosphate + His/in
-
-
-
?
ATP + H2O + His/out
ADP + phosphate + His/in
-
-
-
?
ATP + H2O + His/out
ADP + phosphate + His/in
-
-
-
?
ATP + H2O + His/out
ADP + phosphate + His/in
-
-
-
?
ATP + H2O + His/out
ADP + phosphate + His/in
-
-
-
?
ATP + H2O + His/out
ADP + phosphate + His/in
-
-
-
?
ATP + H2O + His/out
ADP + phosphate + His/in
-
-
-
?
ATP + H2O + His/out
ADP + phosphate + His/in
-
-
-
?
ATP + H2O + His/out
ADP + phosphate + His/in
-
-
-
?
ATP + H2O + His/out
ADP + phosphate + His/in
-
the histidine transport system Hut is also involved in proline and betaine uptake
-
?
ATP + H2O + L-alanine/out
ADP + phosphate + L-alanine/in
-
-
-
-
?
ATP + H2O + L-Arg/out
ADP + phosphate + L-Arg/in
-
the histidine-binding protein HisJ binds L-His and L-Arg tightly and L-Lys and L-Orn less tightly
-
?
ATP + H2O + L-arginine-[L-arginine-binding protein][side 1]
ADP + phosphate + L-arginine[side 2] + [L-arginine-binding protein][side 1]
preferred amino acid
-
-
?
ATP + H2O + L-arginine-[L-arginine-binding protein][side 1]
ADP + phosphate + L-arginine[side 2] + [L-arginine-binding protein][side 1]
-
-
-
-
?
ATP + H2O + L-arginine-[L-arginine-binding protein][side 1]
ADP + phosphate + L-arginine[side 2] + [L-arginine-binding protein][side 1]
Leishmania amazonensis MHOM/BR/1973/2269
-
-
-
-
?
ATP + H2O + L-arginine-[L-arginine-binding protein][side 1]
ADP + phosphate + L-arginine[side 2] + [L-arginine-binding protein][side 1]
-
-
-
-
?
ATP + H2O + L-arginine-[L-arginine-binding protein][side 1]
ADP + phosphate + L-arginine[side 2] + [L-arginine-binding protein][side 1]
-
-
-
?
ATP + H2O + L-arginine-[L-arginine-binding protein][side 1]
ADP + phosphate + L-arginine[side 2] + [L-arginine-binding protein][side 1]
-
-
-
-
?
ATP + H2O + L-arginine-[L-arginine-binding protein][side 1]
ADP + phosphate + L-arginine[side 2] + [L-arginine-binding protein][side 1]
-
-
-
?
ATP + H2O + L-arginine-[L-arginine-binding protein][side 1]
ADP + phosphate + L-arginine[side 2] + [L-arginine-binding protein][side 1]
-
-
-
-
?
ATP + H2O + L-arginine-[L-arginine-binding protein][side 1]
ADP + phosphate + L-arginine[side 2] + [L-arginine-binding protein][side 1]
-
-
-
-
?
ATP + H2O + L-arginine-[L-arginine-binding protein][side 1]
ADP + phosphate + L-arginine[side 2] + [L-arginine-binding protein][side 1]
-
-
-
-
?
ATP + H2O + L-arginine-[L-arginine-binding protein][side 1]
ADP + phosphate + L-arginine[side 2] + [L-arginine-binding protein][side 1]
-
-
-
-
?
ATP + H2O + L-arginine-[L-arginine-binding protein][side 1]
ADP + phosphate + L-arginine[side 2] + [L-arginine-binding protein][side 1]
-
-
-
-
?
ATP + H2O + L-arginine-[L-arginine-binding protein][side 1]
ADP + phosphate + L-arginine[side 2] + [L-arginine-binding protein][side 1]
-
-
-
-
?
ATP + H2O + L-asparagine-[L-asparagine-binding protein][side 1]
ADP + phosphate + L-asparagine[side 2] + [L-asparagine-binding protein][side 1]
-
-
-
-
?
ATP + H2O + L-asparagine-[L-asparagine-binding protein][side 1]
ADP + phosphate + L-asparagine[side 2] + [L-asparagine-binding protein][side 1]
-
-
-
-
?
ATP + H2O + L-asparagine-[L-asparagine-binding protein][side 1]
ADP + phosphate + L-asparagine[side 2] + [L-asparagine-binding protein][side 1]
-
-
-
-
?
ATP + H2O + L-aspartate/out
ADP + phosphate + L-aspartate/in
-
-
-
-
?
ATP + H2O + L-glutamate-[L-glutamate-binding protein][side 1]
ADP + phosphate + L-glutamate[side 2] + [L-glutamate-binding protein][side 1]
-
-
-
-
?
ATP + H2O + L-glutamate-[L-glutamate-binding protein][side 1]
ADP + phosphate + L-glutamate[side 2] + [L-glutamate-binding protein][side 1]
-
-
-
-
?
ATP + H2O + L-glutamate-[L-glutamate-binding protein][side 1]
ADP + phosphate + L-glutamate[side 2] + [L-glutamate-binding protein][side 1]
-
-
-
-
?
ATP + H2O + L-glutamate-[L-glutamate-binding protein][side 1]
ADP + phosphate + L-glutamate[side 2] + [L-glutamate-binding protein][side 1]
-
-
-
?
ATP + H2O + L-glutamate-[L-glutamate-binding protein][side 1]
ADP + phosphate + L-glutamate[side 2] + [L-glutamate-binding protein][side 1]
-
-
-
-
?
ATP + H2O + L-glutamate-[L-glutamate-binding protein][side 1]
ADP + phosphate + L-glutamate[side 2] + [L-glutamate-binding protein][side 1]
-
-
-
-
?
ATP + H2O + L-glutamate/out
ADP + phosphate + L-glutamate/in
-
-
-
-
?
ATP + H2O + L-glutamate/out
ADP + phosphate + L-glutamate/in
-
-
-
-
?
ATP + H2O + L-glutamate/out
ADP + phosphate + L-glutamate/in
-
-
-
-
?
ATP + H2O + L-glutamic acid-[L-glutamic acid-binding protein][side 1]
ADP + phosphate + L-glutamic acid[side 2] + [L-glutamic acid-binding protein][side 1]
-
-
-
-
?
ATP + H2O + L-glutamic acid-[L-glutamic acid-binding protein][side 1]
ADP + phosphate + L-glutamic acid[side 2] + [L-glutamic acid-binding protein][side 1]
-
-
-
-
?
ATP + H2O + L-glutamine-[L-glutamine-binding protein][side 1]
ADP + phosphate + L-glutamine[side 2] + [L-glutamine-binding protein][side 1]
the enzyme is specific for glutamine
-
-
?
ATP + H2O + L-glutamine-[L-glutamine-binding protein][side 1]
ADP + phosphate + L-glutamine[side 2] + [L-glutamine-binding protein][side 1]
-
-
-
-
?
ATP + H2O + L-glutamine-[L-glutamine-binding protein][side 1]
ADP + phosphate + L-glutamine[side 2] + [L-glutamine-binding protein][side 1]
-
-
-
-
?
ATP + H2O + L-glutamine-[L-glutamine-binding protein][side 1]
ADP + phosphate + L-glutamine[side 2] + [L-glutamine-binding protein][side 1]
-
-
-
-
?
ATP + H2O + L-glutamine-[L-glutamine-binding protein][side 1]
ADP + phosphate + L-glutamine[side 2] + [L-glutamine-binding protein][side 1]
-
the enzyme is the only transport system for L-glutamine but not for L-glutamic acid and L-asparagine
-
-
?
ATP + H2O + L-glutamine-[L-glutamine-binding protein][side 1]
ADP + phosphate + L-glutamine[side 2] + [L-glutamine-binding protein][side 1]
-
the enzyme is the only transport system for L-glutamine but not for L-glutamic acid and L-asparagine
-
-
?
ATP + H2O + L-histidine-[L-histidine-binding protein][side 1]
ADP + phosphate + L-histidine[side 2] + [L-histidine-binding protein][side 1]
-
-
-
?
ATP + H2O + L-histidine-[L-histidine-binding protein][side 1]
ADP + phosphate + L-histidine[side 2] + [L-histidine-binding protein][side 1]
-
-
-
-
?
ATP + H2O + L-histidine-[L-histidine-binding protein][side 1]
ADP + phosphate + L-histidine[side 2] + [L-histidine-binding protein][side 1]
-
-
-
-
?
ATP + H2O + L-histidine/out
ADP + phosphate + L-histidine/in
-
-
-
-
?
ATP + H2O + L-histidine/out
ADP + phosphate + L-histidine/in
-
-
-
-
?
ATP + H2O + L-Lys/out
ADP + phosphate + L-Lys/in
-
the histidine-binding protein HisJ binds L-His and L-Arg tightly and L-Lys and L-Orn less tightly