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Information on EC 7.4.2.1 - ABC-type polar-amino-acid transporter

for references in articles please use BRENDA:EC7.4.2.1

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IUBMB Comments

An ATP-binding cassette (ABC) type transporter, characterized by the presence of two similar ATP-binding domains/proteins and two integral membrane domains/proteins. The enzyme, found in bacteria, interacts with an extracytoplasmic substrate binding protein and mediates the import of polar amino acids. This entry comprises bacterial enzymes that import His, Arg, Lys, Glu, Gln, Asp, ornithine, octopine and nopaline.

The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Reaction Schemes
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polar amino acid-[polar amino acid-binding protein][side 1]
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polar amino acid[side 2]
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[polar amino acid-binding protein][side 1]

Synonyms
amino acid transporter, slc7a7, amino acid permease, gap1p, general amino acid permease, slc7a1, slc6a19, histidine permease, glnpq, amino acid/auxin permease, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
ATP + H2O + polar amino acid-[polar amino acid-binding protein][side 1] = ADP + phosphate + polar amino acid[side 2] + [polar amino acid-binding protein][side 1]
show the reaction diagram
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Highest Expressing Human Cell Lines
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