Any feedback?
Information on EC 7.3.2.1 - ABC-type phosphate transporter
for references in articles please use BRENDA:EC7.3.2.1Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
EC Tree
7.3.2.1 ABC-type phosphate transporterIUBMB Comments
An ATP-binding cassette (ABC) type transporter, characterized by the presence of two similar ATP-binding domains/proteins and two integral membrane domains/proteins. A bacterial enzyme that interacts with an extracytoplasmic substrate binding protein and mediates the high affinity uptake of phosphate anions. Unlike P-type ATPases, it does not undergo phosphorylation during the transport process.
Specify your search results
Word Map
- 7.3.2.1
- pituitary
- prolactin
- phosphorus
-
pituitary-specific
- tubule
- calcification
- tsh
- mycorrhizal
-
reabsorption
- parathyroid
-
somatotrophs
-
homeodomain
- hyperphosphatemia
-
lactotrophs
-
co-transporter
-
hypophosphatemic
-
phosphaturic
-
phosphonoformic
-
thyrotropes
-
thyroid-stimulating
- arbuscules
-
p-aminohippurate
- probenecid
-
phosphate-induced
-
sodium-phosphate
-
amphotropic
- rickets
-
rhizophagus
-
non-mycorrhizal
-
corticotrophs
- irregularis
- hypopituitarism
-
phors
-
gh-secreting
- oxonate
- intraradices
-
gh-releasing
-
gonadotrophs
-
nherf1
-
na-dependent
-
para-aminohippurate
-
snell
-
hyperuricemic
-
hypercalciuria
-
hormone-producing
- gibbon
-
uricosuric
-
pi-induced
-
p-deficient
-
factor-23
The expected taxonomic range for this enzyme is: Bacteria, Archaea, Eukaryota
Reaction Schemes
+
+
=
+
+
+
+
+
phosphate-[phosphate-binding protein][side 1]
=
+
+
+
[phosphate-binding protein][side 1]
Synonyms
pit-1, phosphate transporter, npt2a, pho84, anion transporter 1, pit-2, pi transporter, slc20a1, glvr-1, pstscab, 
more
topPlease wait a moment until the data is sorted. This message will disappear when the data is sorted.
SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
ABC phosphate transporter
-
-
-
-
ATP phosphohydrolase (phosphate-importing)
-
-
-
-
phosphate specific transporter
-
-
-
-
phosphate-specific transport system
-
-
-
-
phosphate-transporting ATPase
-
-
-
-
Pst
-
-
-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
hydrolysis of phosphoric acid anhydride
-
-
-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
PATHWAY SOURCE
PATHWAYS
-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
SYSTEMATIC NAME
IUBMB Comments
ATP phosphohydrolase (ABC-type, phosphate-importing)
An ATP-binding cassette (ABC) type transporter, characterized by the presence of two similar ATP-binding domains/proteins and two integral membrane domains/proteins. A bacterial enzyme that interacts with an extracytoplasmic substrate binding protein and mediates the high affinity uptake of phosphate anions. Unlike P-type ATPases, it does not undergo phosphorylation during the transport process.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
CAS REGISTRY NUMBER
COMMENTARY
9000-83-3
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
abc-type phosphate transporter deficiency
Association of patent ductus arteriosus and severe hypothyroidism in term newborns: coincidence or causal?
abc-type phosphate transporter deficiency
Clinical and molecular characterization of a Brazilian patient with Pit-1 deficiency.
abc-type phosphate transporter deficiency
Loss of PiT-2 results in abnormal bone development and decreased bone mineral density and length in mice.
abc-type phosphate transporter deficiency
Organic Anion Transporter 1 Deficiency Accelerates Learning and Memory Impairment in tg2576 Mice by Damaging Dendritic Spine Morphology and Activity.
abc-type phosphate transporter deficiency
Pituitary, pancreatic and gut neuroendocrine defects in protein tyrosine phosphatase-sigma-deficient mice.
abc-type phosphate transporter deficiency
Placental growth hormone and IGF-I in a pregnant woman with Pit-1 deficiency.
abc-type phosphate transporter deficiency
The prenatal role of thyroid hormone evidenced by fetomaternal Pit-1 deficiency.
Achondroplasia
Clinical Characteristics, Etiologies and Pathophysiology of Patients with Severe Short Stature with Severe GH Deficiency: Questionnaire Study on the Data Registered with the Foundation for Growth Science, Japan.
Acidosis
Compensatory regulation of the sodium/phosphate cotransporters NaPi-IIc (SCL34A3) and Pit-2 (SLC20A2) during Pi deprivation and acidosis.
Acromegaly
Digital analysis of hormonal immunostaining in pituitary adenomas classified according to WHO 2017 criteria and correlation with preoperative laboratory findings.
Acromegaly
Multihormonal pituitary adenoma concomitant with Pit-1 and Tpit lineage cells causing acromegaly associated with subclinical Cushing's disease: a case report.
Acromegaly
Silent subtype 3 pituitary adenomas are not always silent and represent poorly differentiated monomorphous plurihormonal Pit-1 lineage adenomas.
ACTH-Secreting Pituitary Adenoma
Clinicopathological analysis of 250 cases of pituitary adenoma under the new WHO classification.
ACTH-Secreting Pituitary Adenoma
The transcription activator steroidogenic factor-1 is preferentially expressed in the human pituitary gonadotroph.
Acute Kidney Injury
Alteration in renal organic anion transporter 1 after ischemia/reperfusion in cadaveric renal allografts.
Acute Kidney Injury
Regulation of the renal sodium-dependent phosphate cotransporter NaPi2 (Npt2) in acute renal failure due to ischemia and reperfusion.
Adenocarcinoma
Cancer progression by breast tumors with Pit-1-overexpression is blocked by inhibition of Metalloproteinase (MMP)-13.
Adenocarcinoma
The vitamin D receptor represses transcription of the pituitary transcription factor Pit-1 gene without involvement of the retinoid X receptor.
Adenoma
A case of pituitary somatotroph adenoma with concomitant secretion of growth hormone, prolactin, and adrenocorticotropic hormone--an adenoma derived from primordial stem cell, studied by immunohistochemistry, in situ hybridization, and cell culture.
Adenoma
ACTH and alpha-Subunit are Co-expressed in Rare Human Pituitary Corticotroph Cell Adenomas Proposed to Originate from ACTH-Committed Early Pituitary Progenitor Cells.
Adenoma
Cell type-specific expression of the pituitary transcription activator pit-1 in the human pituitary and pituitary adenomas.
Adenoma
Clinical and immunohistochemical studies on TSH-secreting pituitary adenoma: its multihormonality and expression of Pit-1.
Adenoma
Clinicopathological analysis of 250 cases of pituitary adenoma under the new WHO classification.
Adenoma
Clinicopathological Features of Growth Hormone-producing Pituitary Adenomas and Correlation With Preoperative Laboratory Findings.
Adenoma
Dietary modulation of the expression of genes involved in short-chain fatty acid absorption in the rumen epithelium is related to short-chain fatty acid concentration and pH in the rumen of goats.
Adenoma
Double adenomas of the pituitary: transcription factors Pit-1, T-pit, and SF-1 identify cytogenesis and differentiation.
Adenoma
Excellent response to pasireotide therapy in an aggressive and dopamine-resistant prolactinoma - commentary.
Adenoma
Expression of activin/inhibin subunit messenger ribonucleic acids by gonadotroph adenomas.
Adenoma
Expression of adrenocorticotropic hormone, prolactin and transcriptional factors in clinically nonfunctioning pituitary adenoma.
Adenoma
Expression of human Pit-1 product in the human pituitary and pituitary adenomas. Immunohistochemical studies using an antibody against synthetic human Pit-1 product.
Adenoma
Expression of Pit-1 and estrogen receptor messenger RNA in prolactin-producing pituitary adenomas.
Adenoma
Expression of Pit-1 and growth hormone-releasing hormone receptor mRNA in human pituitary adenomas: difference among functioning, silent, and other nonfunctioning adenomas.
Adenoma
Expression of Pit-1 mRNA and activin/inhibin subunits in clinically nonfunctioning pituitary adenomas. In situ hybridization and immunohistochemical analysis.
Adenoma
Expression of steroidogenic factor 1 and pituitary specific transcription factor 1 in rat pituitary adenomas.
Adenoma
Fibroblast Growth Factor Receptor-4 Expression in Pituitary Adenomas is Associated with Aggressive Tumor Features.
Adenoma
GH and PRL gene expression by nonradioisotopic in situ hybridization in TSH-secreting pituitary adenomas.
Adenoma
Identification of adrenocorticotropin receptor messenger ribonucleic acid in the human pituitary and its loss of expression in pituitary adenomas.
Adenoma
Immunohistochemical expression of PIT-1 protein in pituitary glands of human GRF transgenic mice: its relationship with hormonal expressions.
Adenoma
In situ hybridization analysis of Pit-1 mRNA and hormonal production in human pituitary adenomas.
Adenoma
Inhibition of intestinal villus cell Na/K-ATPase mediates altered glucose and NaCl absorption in obesity-associated diabetes and hypertension.
Adenoma
Loss of the anion exchanger DRA (Slc26a3), or PAT1 (Slc26a6), alters sulfate transport by the distal ileum and overall sulfate homeostasis.
Adenoma
Lubiprostone Targets Prostanoid Signaling and Promotes Ion Transporter Trafficking, Mucus Exocytosis, and Contractility.
Adenoma
Monomorphous Plurihormonal Pituitary Adenoma of Pit-1 Lineage in a Giant Adolescent with Central Hyperthyroidism.
Adenoma
PAT-1 (Slc26a6) is the predominant apical membrane Cl-/HCO3- exchanger in the upper villous epithelium of the murine duodenum.
Adenoma
Pathological study of thyrotropin-secreting pituitary adenoma: plurihormonality and medical treatment.
Adenoma
Pathology, Pathogenesis and Therapy of Growth Hormone (GH)-producing Pituitary Adenomas: Technical Advances in Histochemistry and Their Contribution.
Adenoma
Pit-1 gene expression in human lactotroph and somatotroph pituitary adenomas is correlated to D2 receptor gene expression.
Adenoma
Pit-1 gene expression in human pituitary adenomas using the reverse transcription polymerase chain reaction method.
Adenoma
Pit-1 messenger ribonucleic acid is differentially expressed in human pituitary adenomas.
Adenoma
Pit-1 positive alpha-subunit positive nonfunctioning human pituitary adenomas: a dedifferentiated GH cell lineage?
Adenoma
Pituitary adenomas that show a faint GH-immunoreactivity but lack fibrous body: Pit-1 adenoma with endocrinologically low activity.
Adenoma
Pituitary specific transcription factor messenger ribonucleic expression in adenomatous and nontumorous human pituitary tissues.
Adenoma
Plurihormonal Pit-1 lineage adenoma presenting as meningitis with recurrence after somatostatin analogue.
Adenoma
Quantitative analysis of growth-related factors in human pituitary adenomas. Lowered insulin-like growth factor-I and its receptor mRNA in growth hormone-producing adenomas.
Adenoma
Silent pituitary plurihormonal adenoma: clinical relevance of immunohistochemical analysis
Adenoma
Silent subtype 3 pituitary adenomas are not always silent and represent poorly differentiated monomorphous plurihormonal Pit-1 lineage adenomas.
Adenoma
Targeted overexpression of luteinizing hormone causes ovary-dependent functional adenomas restricted to cells of the Pit-1 lineage.
Adenoma
Utility of Pit-1 Immunostaining in Distinguishing Pituitary Adenomas of Primitive Differentiation from Null Cell Adenomas.
Alzheimer Disease
Organic Anion Transporter 1 Deficiency Accelerates Learning and Memory Impairment in tg2576 Mice by Damaging Dendritic Spine Morphology and Activity.
Ankylosis
Inhibition of osteoblast mineralization by phosphorylated phage-derived apatite-specific peptide.
Autoimmune Diseases
Two Cases of anti-PIT-1 Hypophysitis Exhibited as a Form of Paraneoplastic Syndrome not Associated With Thymoma.
Autoimmune Hypophysitis
A Novel Clinical Entity of Autoimmune Endocrinopathy: Anti-PIT-1 Antibody Syndrome.
Autoimmune Hypophysitis
A novel thymoma-associated autoimmune disease: Anti-PIT-1 antibody syndrome.
Autoimmune Hypophysitis
Pathogenesis of Anti-PIT-1 Antibody Syndrome: PIT-1 Presentation by HLA Class I on Anterior Pituitary Cells.
Bone Diseases
Loss of PiT-2 results in abnormal bone development and decreased bone mineral density and length in mice.
Bone Diseases, Metabolic
Digenic Heterozygous Mutations in SLC34A3 and SLC34A1 Cause Dominant Hypophosphatemic Rickets with Hypercalciuria.
Breast Neoplasms
A simple method for the isolation and detailed characterization of primary human proximal tubule cells for renal replacement therapy.
Breast Neoplasms
Alterations in Hepatic mRNA Expression of Phase-II Enzymes and Xenobiotic Transporters after Targeted Disruption of Hepatocyte Nuclear Factor 4 alpha.
Breast Neoplasms
Antiretroviral drug transporters and metabolic enzymes in human testicular tissue: potential contribution to HIV-1 sanctuary site.
Breast Neoplasms
Breast cancer metastasis to liver and lung is facilitated by Pit-1-CXCL12-CXCR4 axis.
Breast Neoplasms
Cancer progression by breast tumors with Pit-1-overexpression is blocked by inhibition of Metalloproteinase (MMP)-13.
Breast Neoplasms
Cetuximab Prevents Methotrexate-Induced Cytotoxicity in Vitro through Epidermal Growth Factor Dependent Regulation of Renal Drug Transporters.
Breast Neoplasms
Deregulation of the Pit-1 transcription factor in human breast cancer cells promotes tumor growth and metastasis.
Breast Neoplasms
EGF stimulates Pit-1 independent transcription of the human prolactin pituitary promoter in human breast cancer SK-BR-3 cells through its proximal AP-1 response element.
Breast Neoplasms
Expression Levels of KMT2C and SLC20A1 Identified by Information-theoretical Analysis Are Powerful Prognostic Biomarkers in Estrogen Receptor-positive Breast Cancer.
Breast Neoplasms
H+-dependent inorganic phosphate transporter in breast cancer cells: Possible functions in the tumor microenvironment.
Breast Neoplasms
High SLC20A1 Expression Is Associated With Poor Prognoses in Claudin-low and Basal-like Breast Cancers.
Breast Neoplasms
In Vitro Assessment of the Drug-Drug Interaction Potential of Verinurad and Its Metabolites as Substrates and Inhibitors of Metabolizing Enzymes and Drug Transporters.
Breast Neoplasms
Organic anion transporter 3- and organic anion transporting polypeptides 1B1- and 1B3-mediated transport of catalposide.
Breast Neoplasms
Over-Expression of POU Class 1 Homeobox 1 Transcription Factor (Pit-1) Predicts Poor Prognosis for Breast Cancer Patients.
Breast Neoplasms
Pit-1 inhibits BRCA1 and sensitizes human breast tumors to cisplatin and vitamin D treatment.
Breast Neoplasms
Pit-1 is expressed in normal and tumorous human breast and regulates GH secretion and cell proliferation.
Breast Neoplasms
POU1F1 transcription factor promotes breast cancer metastasis via recruitment and polarization of macrophages.
Breast Neoplasms
Targeting phopshatidylinositol 3-kinase signaling with novel phosphatidylinositol 3,4,5-triphosphate antagonists.
Breast Neoplasms
The Pit-1/Pou1f1 transcription factor regulates and correlates with prolactin expression in human breast cell lines and tumors.
Breast Neoplasms
The vitamin D receptor represses transcription of the pituitary transcription factor Pit-1 gene without involvement of the retinoid X receptor.
Breast Neoplasms
Tissue Distribution, Ontogeny, and Hormonal Regulation of Xenobiotic Transporters in Mouse Kidneys.
Breast Neoplasms
Vitamin D, Pit-1, GH, and PRL: possible roles in breast cancer development.
Carcinogenesis
Immunohistochemical analysis of GH-producing adenomas--with special emphasis on plurihormonality of individual tumor cells by double staining.
Carcinoid Tumor
Acromegaly due to a Macroinvasive Plurihormonal Pituitary Adenoma and a Rectal Carcinoid Tumor.
Carcinoma
Pit-1 is expressed in normal and tumorous human breast and regulates GH secretion and cell proliferation.
Carcinoma
Rebmab200, a humanized monoclonal antibody targeting the sodium phosphate transporter NaPi2b displays strong immune mediated cytotoxicity against cancer: a novel reagent for targeted antibody therapy of cancer.
Carcinoma
The Dolaflexin-based Antibody-Drug Conjugate XMT-1536 Targets the Solid Tumor Lineage Antigen SLC34A2/NaPi2b.
Carcinoma
The POU homeodomain protein OCT3 as a potential transcriptional activator for fibroblast growth factor-4 (FGF-4) in human breast cancer cells.
Carcinoma, Ductal
Deregulation of the Pit-1 transcription factor in human breast cancer cells promotes tumor growth and metastasis.
Carcinoma, Ductal
The Pit-1/Pou1f1 transcription factor regulates and correlates with prolactin expression in human breast cell lines and tumors.
Carcinoma, Hepatocellular
[Inhibited effect of phosphorylated insulin-like growth factor binding protein-1 on hepatoma cells in vitro]
Carcinoma, Ovarian Epithelial
Generation of Monoclonal Antibodies Against Tumor-Associated Antigen MX35/sodium-Dependent Phosphate Transporter NaPi2b.
Carcinoma, Ovarian Epithelial
Sodium-dependent phosphate transporter NaPi2b as a potential predictive marker for targeted therapy of ovarian cancer.
Carcinoma, Ovarian Epithelial
The study of phosphate transporter NAPI2B expression in different histological types of epithelial ovarian cancer.
Carcinoma, Squamous Cell
[Screening and functional analysis of microRNA expression in HPV16-positive squamous carcinoma of the cervix ?in the Uygur of southern Xinjiang].
Chagas Disease
TcPho91 is a contractile vacuole phosphate sodium symporter that regulates phosphate and polyphosphate metabolism in Trypanosoma cruzi.
Cholestasis, Extrahepatic
Expression and function of renal and hepatic organic anion transporters in extrahepatic cholestasis.
Cholestasis, Extrahepatic
Expression of rat renal cortical OAT1 and OAT3 in response to acute biliary obstruction.
Choriocarcinoma
Expression of pit-1 messenger ribonucleic acid and protein in the human placenta.
Choriocarcinoma
Pit-1/growth hormone factor 1 splice variant expression in the rhesus monkey pituitary gland and the rhesus and human placenta.
Congenital Abnormalities
A Novel Clinical Entity of Autoimmune Endocrinopathy: Anti-PIT-1 Antibody Syndrome.
Congenital Abnormalities
Evidence of a congenital midline brain anomaly in pituitary dwarfs: a magnetic resonance imaging study in 101 patients.
Congenital Hypothyroidism
A new C-terminal located mutation (V272ter) in the PIT-1 gene manifesting with severe congenital hypothyroidism. Possible functionality of the PIT-1 C-terminus.
Congenital Hypothyroidism
The prenatal role of thyroid hormone evidenced by fetomaternal Pit-1 deficiency.
Cystic Fibrosis
Intestinal anion exchanger down-regulated in adenoma (DRA) is inhibited by intracellular calcium.
Cystic Fibrosis
Lubiprostone Targets Prostanoid Signaling and Promotes Ion Transporter Trafficking, Mucus Exocytosis, and Contractility.
Drug-Related Side Effects and Adverse Reactions
Molecular Mechanisms for Species Differences in Organic Anion Transporter 1, OAT1: Implications for Renal Drug Toxicity.
Ductus Arteriosus, Patent
Association of patent ductus arteriosus and severe hypothyroidism in term newborns: coincidence or causal?
Dwarfism
Expression of mRNA coding for pituitary hormones and pituitary-specific transcription factor in the pituitary gland of the rdw rat with hereditary dwarfism.
Dwarfism
Genetic mapping of the human pituitary-specific transcriptional factor gene and its analysis in familial panhypopituitary dwarfism.
Dwarfism
Pituitary lineage determination by the Prophet of Pit-1 homeodomain factor defective in Ames dwarfism.
Dwarfism
Pituitary-specific transcription factor Pit-1 in the rdw rat with growth hormone- and prolactin-deficient dwarfism.
Dwarfism
Synergistic interactions between Pit-1 and other elements are required for effective somatotroph rat growth hormone gene expression in transgenic mice.
Dwarfism
The solution structure of the Oct-1 POU-specific domain reveals a striking similarity to the bacteriophage lambda repressor DNA-binding domain.
Dwarfism, Pituitary
Cloning of the canine gene encoding transcription factor Pit-1 and its exclusion as candidate gene in a canine model of pituitary dwarfism.
Dwarfism, Pituitary
Decreased expression of the GHRH receptor gene due to a mutation in a Pit-1 binding site.
Dyslipidemias
Phosphate overload induces podocyte injury via type III Na-dependent phosphate transporter.
Familial Hypophosphatemic Rickets
Analysis of opossum kidney NaPi-IIc sodium-dependent phosphate transporter to understand Pi handling in human kidney.
Familial Hypophosphatemic Rickets
Chromosomal localization of the human renal sodium phosphate transporter to chromosome 5: implications for X-linked hypophosphatemia.
Familial Hypophosphatemic Rickets
Digenic Heterozygous Mutations in SLC34A3 and SLC34A1 Cause Dominant Hypophosphatemic Rickets with Hypercalciuria.
Familial Hypophosphatemic Rickets
Hereditary hypophosphatemic rickets with hypercalciuria: a study for the phosphate transporter gene type IIc and osteoblastic function.
Familial Hypophosphatemic Rickets
Phosphate matters when investigating hypercalcemia: a mutation in SLC34A3 causing HHRH
Familial Hypophosphatemic Rickets
Processing and stability of type IIc sodium-dependent phosphate cotransporter mutations in patients with hereditary hypophosphatemic rickets with hypercalciuria.
Fanconi Syndrome
Time Course of Pathogenic and Adaptation Mechanisms in Cystinotic Mouse Kidneys.
Galactorrhea
Silent subtype 3 pituitary adenomas are not always silent and represent poorly differentiated monomorphous plurihormonal Pit-1 lineage adenomas.
Ganglioneuroma
Mixed Gangliocytoma-Pituitary Adenoma: Insights on the Pathogenesis of a Rare Sellar Tumor.
Genetic Diseases, Inborn
Cloning of the canine gene encoding transcription factor Pit-1 and its exclusion as candidate gene in a canine model of pituitary dwarfism.
Glycogen Storage Disease
NPT4, a new microsomal phosphate transporter: mutation analysis in glycogen storage disease type Ic.
Glycogen Storage Disease
Probing into the function of the gene product responsible for glycogen storage disease type Ib.
Gout
Erratum to: Polymorphisms in GCKR, SLC17A1 and SLC22A12 were associated with phenotype gout in Han Chinese males: a case-control study.
Gout
Polymorphisms in GCKR, SLC17A1 and SLC22A12 were associated with phenotype gout in Han Chinese males: a case-control study.
Gout
Sodium-dependent phosphate cotransporter type 1 (NPT1) sequence polymorphisms in male patients with gout.
Granulomatous Disease, Chronic
Intersection of phosphate transport, oxidative stress and TOR signalling in Candida albicans virulence.
Growth Hormone-Secreting Pituitary Adenoma
A case of pituitary somatotroph adenoma with concomitant secretion of growth hormone, prolactin, and adrenocorticotropic hormone--an adenoma derived from primordial stem cell, studied by immunohistochemistry, in situ hybridization, and cell culture.
Growth Hormone-Secreting Pituitary Adenoma
Clinicopathological analysis of 250 cases of pituitary adenoma under the new WHO classification.
Growth Hormone-Secreting Pituitary Adenoma
Expression of Pit-1 and growth hormone-releasing hormone receptor mRNA in human pituitary adenomas: difference among functioning, silent, and other nonfunctioning adenomas.
Growth Hormone-Secreting Pituitary Adenoma
Free alpha-subunit and intact TSH secretion in vitro are closely associated in human somatotroph adenomas.
Growth Hormone-Secreting Pituitary Adenoma
Impact of gsp oncogene on the expression of genes coding for Gsalpha, Pit-1, Gi2alpha, and somatostatin receptor 2 in human somatotroph adenomas: involvement in octreotide sensitivity.
Growth Hormone-Secreting Pituitary Adenoma
Impact of SLC20A1 on the Wnt/??catenin signaling pathway in somatotroph adenomas.
Growth Hormone-Secreting Pituitary Adenoma
Mixed Gangliocytoma-Pituitary Adenoma: Insights on the Pathogenesis of a Rare Sellar Tumor.
Growth Hormone-Secreting Pituitary Adenoma
Pit-1 gene expression in human lactotroph and somatotroph pituitary adenomas is correlated to D2 receptor gene expression.
Growth Hormone-Secreting Pituitary Adenoma
Utility of Pit-1 Immunostaining in Distinguishing Pituitary Adenomas of Primitive Differentiation from Null Cell Adenomas.
Herpes Simplex
Transcriptional induction of the human prolactin gene by cAMP requires two cis-acting elements and at least the pituitary-specific factor Pit-1.
Hypercholesterolemia
Hypercholesterolemia and effects of high cholesterol diet in type IIa sodium-dependent phosphate co-transporter (Npt2a) deficient mice.
Hyperglycemia
Combined effects of hyperphosphatemia and hyperglycemia on the calcification of cultured human aortic smooth muscle cells.
Hyperparathyroidism, Secondary
Overexpression of parathyroid pituitary-specific transcription factor (Pit)-1 in hyperphosphatemia-induced hyperparathyroidism of chronic renal failure rats.
Hyperparathyroidism, Secondary
Secondary hyperparathyroidism and phosphate sensing in parathyroid glands.
Hyperparathyroidism, Secondary
Up-regulation of Cbfa1 and Pit-1 in calcified artery of uraemic rats with severe hyperphosphataemia and secondary hyperparathyroidism.
Hyperphosphatemia
Combined effects of hyperphosphatemia and hyperglycemia on the calcification of cultured human aortic smooth muscle cells.
Hyperphosphatemia
Correlation among hyperphosphatemia, type II sodium phosphate transporter activity, and vitamin D metabolism in Fgf-23 null mice.
Hyperphosphatemia
Dietary fructose inhibits intestinal calcium absorption and induces vitamin D insufficiency in CKD.
Hyperphosphatemia
Effects of Phosphonoformic Acid and Renagel on Renal Type IIa Sodium-Dependent Phosphate Cotransporter mRNA Expression in Hyperphosphatemia Rats.
Hyperphosphatemia
EOS789, a novel pan-phosphate transporter inhibitor, is effective for the treatment of chronic kidney disease-mineral bone disorder.
Hyperphosphatemia
In vivo evidence for an interplay of FGF23/Klotho/PTH axis on the phosphate handling in renal proximal tubules.
Hyperphosphatemia
Matrix extracellular phosphoglycoprotein (MEPE) is a new bone renal hormone and vascularization modulator.
Hyperphosphatemia
Ornithine is a key mediator in hyperphosphatemia-mediated human umbilical vein endothelial cell apoptosis: Insights gained from metabolomics.
Hyperphosphatemia
Overexpression of parathyroid pituitary-specific transcription factor (Pit)-1 in hyperphosphatemia-induced hyperparathyroidism of chronic renal failure rats.
Hyperphosphatemia
Pharmacological Npt2a Inhibition Causes Phosphaturia and Reduces Plasma Phosphate in Mice with Normal and Reduced Kidney Function.
Hyperphosphatemia
Regulation of the Rat Intestinal Na-dependent Phosphate Transporters by Dietary Phosphate.
Hyperphosphatemia
Significant Species Differences in Intestinal Phosphate Absorption between Dogs, Rats, and Monkeys.
Hyperphosphatemia
Using 99mTc-(V)-DMSA to follow the vascular calcification process in vascular smooth muscle cells based on pit-1 expression.
Hyperprolactinemia
Clinical Implications of the New WHO Classification 2017 for Pituitary Tumors.
Hypersensitivity
Intersection of phosphate transport, oxidative stress and TOR signalling in Candida albicans virulence.
Hypersensitivity
Phosphate is the third nutrient monitored by TOR in Candida albicans and provides a target for fungal-specific indirect TOR inhibition.
Hypersensitivity
The yeast Aft2 transcription factor determines selenite toxicity by controlling the low affinity phosphate transport system.
Hypertension
Association of intergenic polymorphism of organic anion transporter 1 and 3 genes with hypertension and blood pressure response to hydrochlorothiazide.
Hyperthyroidism
Monomorphous Plurihormonal Pituitary Adenoma of Pit-1 Lineage in a Giant Adolescent with Central Hyperthyroidism.
Hyperthyroidism
Silent subtype 3 pituitary adenomas are not always silent and represent poorly differentiated monomorphous plurihormonal Pit-1 lineage adenomas.
Hypoalbuminemia
Phosphate overload induces podocyte injury via type III Na-dependent phosphate transporter.
Hypophosphatemia
1alpha-Hydroxylase gene ablation and Pi supplementation inhibit renal calcification in mice homozygous for the disrupted Npt2a gene.
Hypophosphatemia
Analysis of opossum kidney NaPi-IIc sodium-dependent phosphate transporter to understand Pi handling in human kidney.
Hypophosphatemia
Characterization of FGF23-Dependent Egr-1 Cistrome in the Mouse Renal Proximal Tubule.
Hypophosphatemia
Chromosome assignments of genes for human Na(+)-dependent phosphate co-transporters NaPi-3 and NPT-1.
Hypophosphatemia
Digenic Heterozygous Mutations in SLC34A3 and SLC34A1 Cause Dominant Hypophosphatemic Rickets with Hypercalciuria.
Hypophosphatemia
Estrogen directly and specifically downregulates NaPi-IIa through the activation of both estrogen receptor isoforms (ER? and ER?) in rat kidney proximal tubule.
Hypophosphatemia
Exome sequencing identifies a novel homozygous mutation in the phosphate transporter SLC34A1 in hypophosphatemia and nephrocalcinosis.
Hypophosphatemia
Ezrin, a membrane cytoskeletal cross-linker, is essential for the regulation of phosphate and calcium homeostasis.
Hypophosphatemia
FGF23 decreases renal NaPi-2a and NaPi-2c expression and induces hypophosphatemia in vivo predominantly via FGF receptor 1.
Hypophosphatemia
Hypercholesterolemia and effects of high cholesterol diet in type IIa sodium-dependent phosphate co-transporter (Npt2a) deficient mice.
Hypophosphatemia
Hypophosphatemia in vitamin D receptor null mice: effect of rescue diet on the developmental changes in renal Na+ -dependent phosphate cotransporters.
Hypophosphatemia
Impaired 1,25 dihydroxyvitamin D3 action and hypophosphatemia underlie the altered lacuno-canalicular remodeling observed in the Hyp mouse model of XLH.
Hypophosphatemia
Klotho: a novel phosphaturic substance acting as an autocrine enzyme in the renal proximal tubule.
Hypophosphatemia
Longitudinal study of urinary excretion of phosphate, calcium, and uric acid in mutant NHERF-1 null mice.
Hypophosphatemia
Nephrolithiasis and osteoporosis associated with hypophosphatemia caused by mutations in the type 2a sodium-phosphate cotransporter.
Hypophosphatemia
Regulation of Phosphorus Homeostasis by the Type IIa Na/Phosphate Cotransporter.
Hypophosphatemia
Regulation of phosphorus homeostasis by the type iia na/phosphate cotransporter.
Hypophosphatemia, Familial
Compensatory regulation of the sodium/phosphate cotransporters NaPi-IIc (SCL34A3) and Pit-2 (SLC20A2) during Pi deprivation and acidosis.
Hypophosphatemia, Familial
Differential regulation of the renal sodium-phosphate cotransporters NaPi-IIa, NaPi-IIc, and PiT-2 in dietary potassium deficiency.
Hypophosphatemia, Familial
Estrogen directly and specifically downregulates NaPi-IIa through the activation of both estrogen receptor isoforms (ER? and ER?) in rat kidney proximal tubule.
Hypophosphatemia, Familial
Increase in phosphaturia by inhibition of renal sodium-dependent phosphate cotransporter NPT2a.
Hypophosphatemia, Familial
Klotho: a novel phosphaturic substance acting as an autocrine enzyme in the renal proximal tubule.
Hypophosphatemia, Familial
Klotho: a novel regulator of calcium and phosphorus homeostasis.
Hypophosphatemia, Familial
Pharmacological Npt2a Inhibition Causes Phosphaturia and Reduces Plasma Phosphate in Mice with Normal and Reduced Kidney Function.
Hypophosphatemia, Familial
Regulation of renal sodium-dependent phosphate co-transporter genes (Npt2a and Npt2c) by all-trans-retinoic acid and its receptors.
Hypophosphatemia, Familial
Sirolimus Induced Phosphaturia is Not Caused by Inhibition of Renal Apical Sodium Phosphate Cotransporters.
Hypophosphatemia, Familial
The ClC-5 chloride channel knock-out mouse - an animal model for Dent's disease.
Hypophysitis
Two Cases of anti-PIT-1 Hypophysitis Exhibited as a Form of Paraneoplastic Syndrome not Associated With Thymoma.
Hypopituitarism
Cellular determination in the anterior pituitary gland: PIT-1 and PROP-1 mutations as causes of human combined pituitary hormone deficiency.
Hypopituitarism
Mutation of the POU-specific domain of Pit-1 and hypopituitarism without pituitary hypoplasia.
Hypopituitarism
Severe congenital hypopituitarism with low prolactin levels and age-dependent anterior pituitary hypoplasia: a clue to a PIT-1 mutation.
Hypopituitarism
[Congenital multiple anterior pituitary hormone deficiencies. An approach of pituitary ontogenesis]
Hypothyroidism
A "hot spot" in the Pit-1 gene responsible for combined pituitary hormone deficiency: clinical and molecular correlates.
Hypothyroidism
A new C-terminal located mutation (V272ter) in the PIT-1 gene manifesting with severe congenital hypothyroidism. Possible functionality of the PIT-1 C-terminus.
Hypothyroidism
A new mutation of the gene encoding the transcription factor Pit-1 is responsible for combined pituitary hormone deficiency.
Hypothyroidism
A Novel Clinical Entity of Autoimmune Endocrinopathy: Anti-PIT-1 Antibody Syndrome.
Hypothyroidism
Adult combined GH, prolactin, and TSH deficiency associated with circulating PIT-1 antibody in humans.
Hypothyroidism
Association of patent ductus arteriosus and severe hypothyroidism in term newborns: coincidence or causal?
Hypothyroidism
Central hypothyroidism reveals compound heterozygous mutations in the Pit-1 gene.
Hypothyroidism
Combined pituitary hormone deficiency due to the F135C human Pit-1 (pituitary-specific factor 1) gene mutation: functional and structural correlates.
Hypothyroidism
Pituitary transcription factors: from congenital deficiencies to gene therapy.
Hypothyroidism
Pro239Ser: a novel recessive mutation of the Pit-1 gene in seven Middle Eastern children with growth hormone, prolactin, and thyrotropin deficiency.
Hypothyroidism
The prenatal role of thyroid hormone evidenced by fetomaternal Pit-1 deficiency.
Hypothyroidism
The R271W mutant form of Pit-1 does not act as a dominant inhibitor of Pit-1 action to activate the promoters of GH and prolactin genes.
Infections
Adenoviral expression of NHERF-1 in NHERF-1 null mouse renal proximal tubule cells restores Npt2a regulation by low phosphate media and parathyroid hormone.
Infections
An improved susceptibility test based on Amberlite reveals the potential antilisterial activity of fosfomycin in vitro.
Infections
Definition of a domain of GLVR1 which is necessary for infection by gibbon ape leukemia virus and which is highly polymorphic between species.
Infections
Disruption of Phosphate Homeostasis Sensitizes Staphylococcus aureus to Nutritional Immunity.
Infections
European and African maize cultivars differ in their physiological and molecular responses to mycorrhizal infection.
Infections
Expression of Pit2 sodium-phosphate cotransporter during murine odontogenesis is developmentally regulated.
Infections
Global pattern of gene expression of Xanthomonas axonopodis pv. glycines within soybean leaves.
Infections
Intersection of phosphate transport, oxidative stress and TOR signalling in Candida albicans virulence.
Infections
Mycobacterium tuberculosis Requires Regulation of ESX-5 Secretion for Virulence in Irgm1-Deficient Mice.
Infections
Phosphate Transporter PstSCAB of Campylobacter jejuni Is a Critical Determinant of Lactate-Dependent Growth and Colonization in Chickens.
Infections
Rapid retroviral infection of human haemopoietic cells of different lineages: efficient transfer in fresh T cells.
Infections
Simultaneous infection with retroviruses pseudotyped with different envelope proteins bypasses viral receptor interference associated with colocalization of gp70 and target cells on fibronectin CH-296.
Infections
Subcellular redistribution of Pit-2 P(i) transporter/amphotropic leukemia virus (A-MuLV) receptor in A-MuLV-infected NIH 3T3 fibroblasts: involvement in superinfection interference.
Infections
Targeting of c-Met and Urokinase Expressing Human Glioma Cell Lines by Retrovirus Vector Displaying Single-Chain Variable Fragment Antibody.
Infections
The cellular receptor for gibbon ape leukemia virus is a novel high affinity sodium-dependent phosphate transporter.
Infections
The dual-function hamster receptor for amphotropic murine leukemia virus (MuLV), 10A1 MuLV, and gibbon ape leukemia virus is a phosphate symporter.
Infections
The high-affinity phosphate transporter Pst is a virulence factor for Proteus mirabilis during complicated urinary tract infection.
Infections
The Rice Phosphate Transporter Protein OsPT8 Regulates Disease Resistance and Plant Growth.
Infertility, Male
The testis anion transporter TAT1 (SLC26A8) physically and functionally interacts with the cystic fibrosis transmembrane conductance regulator channel: a potential role during sperm capacitation.
Insulin Resistance
Elk-1, C/EBPalpha, and Pit-1 confer an insulin-responsive phenotype on prolactin promoter expression in Chinese hamster ovary cells and define the factors required for insulin-increased transcription.
Kidney Failure, Chronic
Overexpression of parathyroid pituitary-specific transcription factor (Pit)-1 in hyperphosphatemia-induced hyperparathyroidism of chronic renal failure rats.
Kidney Failure, Chronic
Phosphate-induced autophagy counteracts vascular calcification by reducing matrix vesicle release.
Leishmaniasis, Visceral
Detection and characterization of a sialoglycosylated bacterial ABC-type phosphate transporter protein from patients with visceral leishmaniasis.
Leishmaniasis, Visceral
Pi inhibits intracellular accumulation of methylglyoxal in promastigote form of L. donovani.
Leukemia
A family of retroviruses that utilize related phosphate transporters for cell entry.
Leukemia
A new structural arrangement of the extracellular regions of the phosphate transporter SLC20A1, the receptor for gibbon ape Leukemia virus.
Leukemia
Amphotropic or gibbon ape leukemia virus retrovirus binding and transduction correlates with the level of receptor mRNA in human hematopoietic cell lines.
Leukemia
Cell signaling through the protein kinases cAMP-dependent protein kinase, protein kinase Cepsilon, and RAF-1 regulates amphotropic murine leukemia virus envelope protein-induced syncytium formation.
Leukemia
Characterization of the human Glvr-1 phosphate transporter/retrovirus receptor gene and promoter region.
Leukemia
Definition of a domain of GLVR1 which is necessary for infection by gibbon ape leukemia virus and which is highly polymorphic between species.
Leukemia
Effects of keratinocyte and hepatocyte growth factor in vivo: implications for retrovirus-mediated gene transfer to liver.
Leukemia
Efficient tumor transduction and antitumor efficacy in experimental human osteosarcoma using retroviral replicating vectors.
Leukemia
Fungal phosphate transporter serves as a receptor backbone for gibbon ape leukemia virus.
Leukemia
Immunodetection of a type III sodium-dependent phosphate cotransporter in tissues and OK cells.
Leukemia
Inter-retroviral fusion mediated by human immunodeficiency virus or murine leukemia virus glycoproteins: independence of cellular membranes and membrane vesicles.
Leukemia
Modulation of phosphate uptake and amphotropic murine leukemia virus entry by posttranslational modifications of PIT-2.
Leukemia
Pit2 assemblies at the cell surface are modulated by extracellular inorganic phosphate concentration.
Leukemia
RANKL-RANK signaling regulates expression of xenotropic and polytropic virus receptor (XPR1) in osteoclasts.
Leukemia
Retrovirus packaging cells based on 10A1 murine leukemia virus for production of vectors that use multiple receptors for cell entry.
Leukemia
Role of chimeric murine leukemia virus env beta-turn polyproline spacers in receptor cooperation.
Leukemia
Simultaneous infection with retroviruses pseudotyped with different envelope proteins bypasses viral receptor interference associated with colocalization of gp70 and target cells on fibronectin CH-296.
Leukemia
Subcellular redistribution of Pit-2 P(i) transporter/amphotropic leukemia virus (A-MuLV) receptor in A-MuLV-infected NIH 3T3 fibroblasts: involvement in superinfection interference.
Leukemia
The cellular receptor for gibbon ape leukemia virus is a novel high affinity sodium-dependent phosphate transporter.
Leukemia
The dual-function hamster receptor for amphotropic murine leukemia virus (MuLV), 10A1 MuLV, and gibbon ape leukemia virus is a phosphate symporter.
Leukemia
Up-regulation of the Pit-2 phosphate transporter/retrovirus receptor by protein kinase C epsilon.
Leukemia, Feline
A new structural arrangement of the extracellular regions of the phosphate transporter SLC20A1, the receptor for gibbon ape Leukemia virus.
Lung Neoplasms
Sodium-dependent phosphate transporter NaPi2b as a potential predictive marker for targeted therapy of ovarian cancer.
Malnutrition
Expression of a xanthine permease and phosphate transporter in cultures and field populations of the harmful alga Aureococcus anophagefferens: tracking nutritional deficiency during brown tides.
Meningitis
Plurihormonal Pit-1 lineage adenoma presenting as meningitis with recurrence after somatostatin analogue.
Mesothelioma
Highly efficient tumor transduction and antitumor efficacy in experimental human malignant mesothelioma using replicating gibbon ape leukemia virus.
Metabolic Diseases
Direct promoter induction of p19Arf by Pit-1 explains the dependence receptor RET/Pit-1/p53-induced apoptosis in the pituitary somatotroph cells.
Multiple Endocrine Neoplasia Type 2b
Clinicopathological analysis of 250 cases of pituitary adenoma under the new WHO classification.
Neoplasm Metastasis
Breast cancer metastasis to liver and lung is facilitated by Pit-1-CXCL12-CXCR4 axis.
Neoplasm Metastasis
Cancer progression by breast tumors with Pit-1-overexpression is blocked by inhibition of Metalloproteinase (MMP)-13.
Neoplasm Metastasis
Deregulation of the Pit-1 transcription factor in human breast cancer cells promotes tumor growth and metastasis.
Neoplasm Metastasis
POU1F1 transcription factor promotes breast cancer metastasis via recruitment and polarization of macrophages.
Neoplasms
A case of Cushing's disease caused by pituitary adenoma producing adrenocorticotropic hormone and growth hormone concomitantly: aberrant expression of transcription factors NeuroD1 and Pit-1 as a proposed mechanism.
Neoplasms
A growth hormone-releasing hormone-producing pancreatic islet cell tumor metastasized to the pituitary is associated with pituitary somatotroph hyperplasia and acromegaly.
Neoplasms
A single- center experience of prolactin-producing pituitary adenomas without hyperprolactinemia: Its incidence and clinical management.
Neoplasms
A thyrotrope-specific variant of Pit-1 transactivates the thyrotropin beta promoter.
Neoplasms
Activin inhibits pituitary prolactin expression and cell growth through Smads, Pit-1 and menin.
Neoplasms
Advances and controversies in the classification and grading of pituitary tumors.
Neoplasms
Breast cancer metastasis to liver and lung is facilitated by Pit-1-CXCL12-CXCR4 axis.
Neoplasms
Cancer progression by breast tumors with Pit-1-overexpression is blocked by inhibition of Metalloproteinase (MMP)-13.
Neoplasms
Characterization of novel human ovarian cancer-specific transcripts (HOSTs) identified by serial analysis of gene expression.
Neoplasms
Corticotroph Aggressive Pituitary Tumors and Carcinomas Frequently Harbor ATRX Mutations.
Neoplasms
Deregulation of the Pit-1 transcription factor in human breast cancer cells promotes tumor growth and metastasis.
Neoplasms
Downregulation of renal type IIa sodium-dependent phosphate cotransporter during lipopolysaccharide-induced acute inflammation.
Neoplasms
Expression and alternative splicing of Pit-1 messenger ribonucleic acid in pituitary adenomas.
Neoplasms
Expression of Pit-1 and growth hormone-releasing hormone receptor mRNA in human pituitary adenomas: difference among functioning, silent, and other nonfunctioning adenomas.
Neoplasms
GATA3 immunoreactivity expands the transcription factor profile of pituitary neuroendocrine tumors.
Neoplasms
H+-dependent inorganic phosphate transporter in breast cancer cells: Possible functions in the tumor microenvironment.
Neoplasms
High SLC20A1 Expression Is Associated With Poor Prognoses in Claudin-low and Basal-like Breast Cancers.
Neoplasms
How Valuable Is the RT-qPCR of Pituitary-Specific Transcription Factors for Identifying Pituitary Neuroendocrine Tumor Subtypes According to the New WHO 2017 Criteria?
Neoplasms
Identification of a novel function of PiT1 critical for cell proliferation and independent from its phosphate transport activity.
Neoplasms
Impact of SLC20A1 on the Wnt/??catenin signaling pathway in somatotroph adenomas.
Neoplasms
Inactivation of transcription factor pit-1 to target tumoral somatolactotroph cells.
Neoplasms
Inorganic phosphate transporters in cancer: Functions, molecular mechanisms and possible clinical applications.
Neoplasms
Localization of somatostatin receptor subtype mRNA in the rat gastrointestinal tract and regulation of SSTR1 gene expression.
Neoplasms
Malignant transformation in non-functioning pituitary adenomas (pituitary carcinoma).
Neoplasms
Mixed Gangliocytoma-Pituitary Adenoma: Insights on the Pathogenesis of a Rare Sellar Tumor.
Neoplasms
Monomorphous Plurihormonal Pituitary Adenoma of Pit-1 Lineage in a Giant Adolescent with Central Hyperthyroidism.
Neoplasms
Multihormonal pituitary adenoma concomitant with Pit-1 and Tpit lineage cells causing acromegaly associated with subclinical Cushing's disease: a case report.
Neoplasms
Optimization of the anti-cancer activity of phosphatidylinositol-3 kinase pathway inhibitor PITENIN-1: switching a thiourea with 1,2,3-triazole.
Neoplasms
Over-Expression of POU Class 1 Homeobox 1 Transcription Factor (Pit-1) Predicts Poor Prognosis for Breast Cancer Patients.
Neoplasms
Overexpression of SLC34A2 is an independent prognostic indicator in bladder cancer and its depletion suppresses tumor growth via decreasing c-Myc expression and transcriptional activity.
Neoplasms
PD-L1 Is Preferentially Expressed in PIT-1 Positive Pituitary Neuroendocrine Tumours.
Neoplasms
Pit-1 gene expression in human lactotroph and somatotroph pituitary adenomas is correlated to D2 receptor gene expression.
Neoplasms
Pit-1 gene expression in human pituitary adenomas using the reverse transcription polymerase chain reaction method.
Neoplasms
Pit-1 inhibits BRCA1 and sensitizes human breast tumors to cisplatin and vitamin D treatment.
Neoplasms
Pit-1 messenger ribonucleic acid is differentially expressed in human pituitary adenomas.
Neoplasms
Pituitary Gangliocytoma Producing TSH and TRH: A Review of "Gangliocytomas of the Sellar Region".
Neoplasms
Pituitary specific transcription factor messenger ribonucleic expression in adenomatous and nontumorous human pituitary tissues.
Neoplasms
Plurihormonal Pit-1 lineage adenoma presenting as meningitis with recurrence after somatostatin analogue.
Neoplasms
Plurihormonal Pituitary Tumor of Pit-1 and SF-1 Lineages, with Synchronous Collision Corticotroph Tumor: a Possible Stem Cell Phenomenon.
Neoplasms
POU1F1 transcription factor promotes breast cancer metastasis via recruitment and polarization of macrophages.
Neoplasms
Rebmab200, a humanized monoclonal antibody targeting the sodium phosphate transporter NaPi2b displays strong immune mediated cytotoxicity against cancer: a novel reagent for targeted antibody therapy of cancer.
Neoplasms
Reverse transcription polymerase chain reaction analysis of pituitary hormone, Pit-1 and steroidogenic factor-1 messenger RNA expression in pituitary tumors.
Neoplasms
Silent subtype 3 pituitary adenomas are not always silent and represent poorly differentiated monomorphous plurihormonal Pit-1 lineage adenomas.
Neoplasms
Small molecule inhibition of phosphatidylinositol-3,4,5-triphosphate (PIP3) binding to pleckstrin homology domains.
Neoplasms
Solute carrier family 34 member 2 overexpression contributes to tumor growth and poor patient survival in colorectal cancer.
Neoplasms
The Dolaflexin-based Antibody-Drug Conjugate XMT-1536 Targets the Solid Tumor Lineage Antigen SLC34A2/NaPi2b.
Neoplasms
Utility of GATA-3 Expression in the Analysis of Pituitary Neuroendocrine Tumour (PitNET) Transcription Factors.
Nephrocalcinosis
Exome sequencing identifies a novel homozygous mutation in the phosphate transporter SLC34A1 in hypophosphatemia and nephrocalcinosis.
Nephrocalcinosis
Intraperitoneal pyrophosphate treatment reduces renal calcifications in Npt2a null mice.
Nephrolithiasis
Sodium-phosphate cotransporters, nephrolithiasis and bone demineralization.
Neuroblastoma
Cooperative dimerization of the POU domain protein Brn-2 on a new motif activates the neuronal promoter of the human aromatic L-amino acid decarboxylase gene.
Neuroendocrine Tumors
PD-L1 Is Preferentially Expressed in PIT-1 Positive Pituitary Neuroendocrine Tumours.
Obstetric Labor, Premature
Comparing the expression patterns of placental magnesium/phosphorus-transporting channels between healthy and preeclamptic pregnancies.
Osteomalacia
Hypophosphatemic rickets accompanying McCune-Albright syndrome: evidence that a humoral factor causes hypophosphatemia.
Osteomalacia
Nuclear isoforms of fibroblast growth factor 2 are novel inducers of hypophosphatemia via modulation of FGF23 and KLOTHO.
Osteosarcoma
Efficient tumor transduction and antitumor efficacy in experimental human osteosarcoma using retroviral replicating vectors.
Osteosarcoma
Expression of a newly identified phosphate transporter/retrovirus receptor in human SaOS-2 osteoblast-like cells and its regulation by insulin-like growth factor I.
Ovarian Neoplasms
Sodium-dependent phosphate transporter NaPi2b as a potential predictive marker for targeted therapy of ovarian cancer.
Ovarian Neoplasms
The study of phosphate transporter NAPI2B expression in different histological types of epithelial ovarian cancer.
Pituitary ACTH Hypersecretion
A case of Cushing's disease caused by pituitary adenoma producing adrenocorticotropic hormone and growth hormone concomitantly: aberrant expression of transcription factors NeuroD1 and Pit-1 as a proposed mechanism.
Pituitary ACTH Hypersecretion
Digital analysis of hormonal immunostaining in pituitary adenomas classified according to WHO 2017 criteria and correlation with preoperative laboratory findings.
Pituitary ACTH Hypersecretion
Multihormonal pituitary adenoma concomitant with Pit-1 and Tpit lineage cells causing acromegaly associated with subclinical Cushing's disease: a case report.
Pituitary Neoplasms
A case of Cushing's disease caused by pituitary adenoma producing adrenocorticotropic hormone and growth hormone concomitantly: aberrant expression of transcription factors NeuroD1 and Pit-1 as a proposed mechanism.
Pituitary Neoplasms
A case of pituitary somatotroph adenoma with concomitant secretion of growth hormone, prolactin, and adrenocorticotropic hormone--an adenoma derived from primordial stem cell, studied by immunohistochemistry, in situ hybridization, and cell culture.
Pituitary Neoplasms
Acromegaly due to a Macroinvasive Plurihormonal Pituitary Adenoma and a Rectal Carcinoid Tumor.
Pituitary Neoplasms
An alternatively spliced Pit-1 isoform altered in its ability to trans-activate.
Pituitary Neoplasms
Cell type-specific expression of the pituitary transcription activator pit-1 in the human pituitary and pituitary adenomas.
Pituitary Neoplasms
Characterization of Prophet of Pit-1 gene expression in normal pituitary and pituitary adenomas in humans.
Pituitary Neoplasms
Clinical and immunohistochemical studies on TSH-secreting pituitary adenoma: its multihormonality and expression of Pit-1.
Pituitary Neoplasms
Clinical Implications of the New WHO Classification 2017 for Pituitary Tumors.
Pituitary Neoplasms
Clinicopathological analysis of 250 cases of pituitary adenoma under the new WHO classification.
Pituitary Neoplasms
Correlation of Pit-1 gene expression and Pit-1 content with proliferation and differentiation in human myeloid leukemic cells.
Pituitary Neoplasms
Expression and alternative splicing of Pit-1 messenger ribonucleic acid in pituitary adenomas.
Pituitary Neoplasms
Expression of human Pit-1 product in the human pituitary and pituitary adenomas. Immunohistochemical studies using an antibody against synthetic human Pit-1 product.
Pituitary Neoplasms
Expression of Pit-1 and growth hormone-releasing hormone receptor mRNA in human pituitary adenomas: difference among functioning, silent, and other nonfunctioning adenomas.
Pituitary Neoplasms
Expression of Pit-1 and related proteins in diverse human pituitary adenomas.
Pituitary Neoplasms
Expression of Pit-1 mRNA and activin/inhibin subunits in clinically nonfunctioning pituitary adenomas. In situ hybridization and immunohistochemical analysis.
Pituitary Neoplasms
Fibroblast Growth Factor Receptor-4 Expression in Pituitary Adenomas is Associated with Aggressive Tumor Features.
Pituitary Neoplasms
Functional significance of prop-1 gene expression in pituitary adenomas.
Pituitary Neoplasms
Identification of adrenocorticotropin receptor messenger ribonucleic acid in the human pituitary and its loss of expression in pituitary adenomas.
Pituitary Neoplasms
Immunohistochemical expression of Pit-1 protein in human pituitary adenomas.
Pituitary Neoplasms
Immunohistochemical expression of PIT-1 protein in pituitary glands of human GRF transgenic mice: its relationship with hormonal expressions.
Pituitary Neoplasms
Immunolocalization of Pit-1 in gonadotroph nuclei is indicative of the transdifferentiation of gonadotroph to lactotroph cells in prolactinomas induced by estrogen.
Pituitary Neoplasms
In situ hybridization analysis of Pit-1 mRNA and hormonal production in human pituitary adenomas.
Pituitary Neoplasms
Induction of GH, PRL, and TSH beta mRNA by transfection of Pit-1 in a human pituitary adenoma-derived cell line.
Pituitary Neoplasms
Monomorphous Plurihormonal Pituitary Adenoma of Pit-1 Lineage in a Giant Adolescent with Central Hyperthyroidism.
Pituitary Neoplasms
Multihormonal pituitary adenoma concomitant with Pit-1 and Tpit lineage cells causing acromegaly associated with subclinical Cushing's disease: a case report.
Pituitary Neoplasms
No Evidence for WT1 Involvement in a Beta-Catenin-Independent Activation of the Wnt Signaling Pathway in Pituitary Adenomas.
Pituitary Neoplasms
Pit-1 gene expression in human lactotroph and somatotroph pituitary adenomas is correlated to D2 receptor gene expression.
Pituitary Neoplasms
Pit-1 gene expression in human pituitary adenomas using the reverse transcription polymerase chain reaction method.
Pituitary Neoplasms
Pit-1 messenger ribonucleic acid is differentially expressed in human pituitary adenomas.
Pituitary Neoplasms
Pit-1 positive alpha-subunit positive nonfunctioning human pituitary adenomas: a dedifferentiated GH cell lineage?
Pituitary Neoplasms
Pit-1 upregulation by HMGA proteins has a role in pituitary tumorigenesis.
Pituitary Neoplasms
Pituitary adenomas that show a faint GH-immunoreactivity but lack fibrous body: Pit-1 adenoma with endocrinologically low activity.
Pituitary Neoplasms
Pituitary specific transcription factor messenger ribonucleic expression in adenomatous and nontumorous human pituitary tissues.
Pituitary Neoplasms
Pituitary transcription factors in the immunohistochemical and molecular diagnosis of pituitary tumours - a systematic review.
Pituitary Neoplasms
Plurihormonal Pit-1 lineage adenoma presenting as meningitis with recurrence after somatostatin analogue.
Pituitary Neoplasms
Plurihormonal Pituitary Tumor of Pit-1 and SF-1 Lineages, with Synchronous Collision Corticotroph Tumor: a Possible Stem Cell Phenomenon.
Pituitary Neoplasms
Reverse transcription polymerase chain reaction analysis of pituitary hormone, Pit-1 and steroidogenic factor-1 messenger RNA expression in pituitary tumors.
Pituitary Neoplasms
Silent subtype 3 pituitary adenomas are not always silent and represent poorly differentiated monomorphous plurihormonal Pit-1 lineage adenomas.
Pituitary Neoplasms
Steroidogenic Factor 1, Pit-1, and Adrenocorticotropic Hormone: A Rational Starting Place for the Immunohistochemical Characterization of Pituitary Adenoma.
Pituitary Neoplasms
The rat growth hormone-releasing hormone receptor gene: structure, regulation, and generation of receptor isoforms with different signaling properties.
Pituitary Neoplasms
The Role of T-box Transcription Factor in a Pituitary Adenoma Diagnostic Algorithm.
Pituitary Neoplasms
The transcription activator steroidogenic factor-1 is preferentially expressed in the human pituitary gonadotroph.
Pituitary Neoplasms
The transcriptional regulation of the growth hormone gene is conserved in vertebrate evolution.
Pituitary Neoplasms
Utility of Pit-1 Immunostaining in Distinguishing Pituitary Adenomas of Primitive Differentiation from Null Cell Adenomas.
Potassium Deficiency
Differential regulation of the renal sodium-phosphate cotransporters NaPi-IIa, NaPi-IIc, and PiT-2 in dietary potassium deficiency.
Pre-Eclampsia
Slc20a2 deficiency results in fetal growth restriction and placental calcification associated with thickened basement membranes and novel CD13 and laminin?1 expressing cells.
Prolactinoma
Activin-inhibitory action on lactotrophs is decreased in lactotroph hyperplasia.
Prolactinoma
Cell type-specific expression of the pituitary transcription activator pit-1 in the human pituitary and pituitary adenomas.
Prolactinoma
Clinicopathological analysis of 250 cases of pituitary adenoma under the new WHO classification.
Prolactinoma
Expression of Pit-1 and estrogen receptor messenger RNA in prolactin-producing pituitary adenomas.
Prolactinoma
Expression of Pit-1 and growth hormone-releasing hormone receptor mRNA in human pituitary adenomas: difference among functioning, silent, and other nonfunctioning adenomas.
Prolactinoma
Immunolocalization of Pit-1 in gonadotroph nuclei is indicative of the transdifferentiation of gonadotroph to lactotroph cells in prolactinomas induced by estrogen.
Prolactinoma
Molecular pathogenesis of human prolactinomas identified by gene expression profiling, RT-qPCR, and proteomic analyses.
Prolactinoma
Pituitary lactotroph adenomas develop after prolonged lactotroph hyperplasia in dopamine D2 receptor-deficient mice.
Prolactinoma
Pituitary transcription factors: from congenital deficiencies to gene therapy.
Proteinuria
Phosphate overload induces podocyte injury via type III Na-dependent phosphate transporter.
Pseudomonas Infections
Circadian Clock-Regulated Phosphate Transporter PHT4;1 Plays an Important Role in Arabidopsis Defense.
Renal Insufficiency
Deregulated Renal Calcium and Phosphate Transport during Experimental Kidney Failure.
Renal Insufficiency
Differential contributions of rOat1 (Slc22a6) and rOat3 (Slc22a8) to the in vivo renal uptake of uremic toxins in rats.
Renal Insufficiency
Nicotinamide prevents the development of hyperphosphataemia by suppressing intestinal sodium-dependent phosphate transporter in rats with adenine-induced renal failure.
Renal Insufficiency
Phosphate excretion and phosphate transporter messenger RNA in uremic rats treated with phosphonoformic acid.
Renal Insufficiency, Chronic
A novel SNP in the 5' regulatory region of organic anion transporter 1 is associated with chronic kidney disease.
Renal Insufficiency, Chronic
Evidence of an intestinal phosphate transporter alternative to type IIb sodium-dependent phosphate transporter in rats with chronic kidney disease.
Renal Insufficiency, Chronic
Phosphate overload induces podocyte injury via type III Na-dependent phosphate transporter.
Renal Insufficiency, Chronic
PiT-2, a type III sodium-dependent phosphate transporter, protects against vascular calcification in mice with chronic kidney disease fed a high-phosphate diet.
Renal Insufficiency, Chronic
Receptor for advanced glycation end products: a key molecule in the genesis of chronic kidney disease vascular calcification and a potential modulator of sodium phosphate co-transporter PIT-1 expression.
Renal Insufficiency, Chronic
Regulation of the Rat Intestinal Na-dependent Phosphate Transporters by Dietary Phosphate.
Renal Insufficiency, Chronic
Sodium-Dependent Phosphate Cotransporters and Phosphate-Induced Calcification of Vascular Smooth Muscle Cells: Redundant Roles for PiT-1 and PiT-2.
Renal Insufficiency, Chronic
[Progress in the identification of intestinal Pi transport inhibitors]
Retroviridae Infections
Modulation of phosphate uptake and amphotropic murine leukemia virus entry by posttranslational modifications of PIT-2.
Rickets
Analysis of opossum kidney NaPi-IIc sodium-dependent phosphate transporter to understand Pi handling in human kidney.
Rickets
Chromosomal localization of the human renal sodium phosphate transporter to chromosome 5: implications for X-linked hypophosphatemia.
Rickets
Hypophosphatemia in vitamin D receptor null mice: effect of rescue diet on the developmental changes in renal Na+ -dependent phosphate cotransporters.
Rickets
HYPOPHOSPHATEMIC RICKETS WITH HYPERCALCIURIA: A NOVEL HOMOZYGOUS MUTATION IN SLC34A3 AND LITERATURE REVIEW.
Rickets, Hypophosphatemic
Chromosomal localization of the human renal sodium phosphate transporter to chromosome 5: implications for X-linked hypophosphatemia.
Rickets, Hypophosphatemic
HYPOPHOSPHATEMIC RICKETS WITH HYPERCALCIURIA: A NOVEL HOMOZYGOUS MUTATION IN SLC34A3 AND LITERATURE REVIEW.
Sarcoma, Avian
Genomic structure and functional analysis of promoter region of somatolactin gene of sea bream (Sparus aurata).
Severe Combined Immunodeficiency
Cancer progression by breast tumors with Pit-1-overexpression is blocked by inhibition of Metalloproteinase (MMP)-13.
Starvation
A Brassica napus PHT1 phosphate transporter, BnPht1;4, promotes phosphate uptake and affects roots architecture of transgenic Arabidopsis.
Starvation
A Constitutive Expressed Phosphate Transporter, OsPht1;1, Modulates Phosphate Uptake and Translocation in Phosphate-Replete Rice.
Starvation
An intracellular phosphate buffer filters transient fluctuations in extracellular phosphate levels.
Starvation
Arabidopsis thaliana high-affinity phosphate transporters exhibit multiple levels of posttranslational regulation.
Starvation
Arabidopsis WRKY45 Transcription Factor Activates PHOSPHATE TRANSPORTER1;1 Expression in Response to Phosphate Starvation.
Starvation
Arbuscular mycorrhizal fungi differ in their ability to regulate the expression of phosphate transporters in maize (Zea mays L.).
Starvation
Cloning and characterization of two phosphate transporters from Medicago truncatula roots: regulation in response to phosphate and to colonization by arbuscular mycorrhizal (AM) fungi.
Starvation
Coregulated expression of the Na+/phosphate Pho89 transporter and Ena1 Na+-ATPase allows their functional coupling under high-pH stress.
Starvation
Differential roles for the low-affinity phosphate transporters Pho87 and Pho90 in Saccharomyces cerevisiae.
Starvation
Disruption of Phosphate Homeostasis Sensitizes Staphylococcus aureus to Nutritional Immunity.
Starvation
Effects of phosphorus starvation versus limitation on the marine cyanobacterium Prochlorococcus?MED4 II: gene expression.
Starvation
Expression of Pit2 sodium-phosphate cotransporter during murine odontogenesis is developmentally regulated.
Starvation
Functional properties and expression quantitative trait loci for phosphate transporter GmPT1 in soybean.
Starvation
Genome-Wide Identification and Expression Profile Analysis of the PHT1 Gene Family in Gossypium hirsutum and Its Two Close Relatives of Subgenome Donor Species.
Starvation
High level of zinc triggers phosphorus starvation by inhibiting root-to-shoot translocation and preferential distribution of phosphorus in rice plants.
Starvation
Identification of Long Non-Coding RNAs and the Regulatory Network Responsive to Arbuscular Mycorrhizal Fungi Colonization in Maize Roots.
Starvation
Identification of phosphatin, a drug alleviating phosphate starvation responses in Arabidopsis.
Starvation
Molecular cloning and functional analysis of two phosphate transporter genes from Rhizopogon luteolus and Leucocortinarius bulbiger, two ectomycorrhizal fungi of Pinus tabulaeformis.
Starvation
OsCYCP1;1, a PHO80 homologous protein, negatively regulates phosphate starvation signaling in the roots of rice (Oryza sativa L.).
Starvation
OsPht1;8, a phosphate transporter, is involved in auxin and phosphate starvation response in rice.
Starvation
OsPT2, a phosphate transporter, is involved in the active uptake of selenite in rice.
Starvation
OsUEV1B, an Ubc enzyme variant protein, is required for phosphate homeostasis in rice.
Starvation
Pho86p, an endoplasmic reticulum (ER) resident protein in Saccharomyces cerevisiae, is required for ER exit of the high-affinity phosphate transporter Pho84p.
Starvation
Phosphate transporter mediated lipid accumulation in Saccharomyces cerevisiae under phosphate starvation conditions.
Starvation
Phosphate utilization efficiency correlates with expression of low-affinity phosphate transporters and noncoding RNA, IPS1, in barley.
Starvation
Phosphate-Starvation-Inducible S-Like RNase Genes in Rice Are Involved in Phosphate Source Recycling by RNA Decay.
Starvation
Phosphoric Metabolites Link Phosphate Import and Polysaccharide Biosynthesis for Candida albicans Cell Wall Maintenance.
Starvation
Promoter deletion analysis elucidates the role of cis elements and 5'UTR intron in spatiotemporal regulation of AtPht1;4 expression in Arabidopsis.
Starvation
Regulation of cation-coupled high-affinity phosphate uptake in the yeast Saccharomyces cerevisiae.
Starvation
Regulation of the pstSCAB operon in Corynebacterium glutamicum by the regulator of acetate metabolism RamB.
Starvation
TaMIR1139: a wheat miRNA responsive to Pi-starvation, acts a critical mediator in modulating plant tolerance to Pi deprivation.
Starvation
The cis-acting CTTC-P1BS module is indicative for gene function of LjVTI12, a Qb-SNARE protein gene that is required for arbuscule formation in Lotus japonicus.
Starvation
The enhanced phosphorus use efficiency in phosphate-deficient and mycorrhiza-inoculated barley seedlings involves activation of different sets of PHT1 transporters in roots.
Starvation
The Phosphate Transporter Gene OsPht1;4 Is Involved in Phosphate Homeostasis in Rice.
Starvation
The Pht1;9 and Pht1;8 transporters mediate inorganic phosphate acquisition by the Arabidopsis thaliana root during phosphorus starvation.
Starvation
The pstSCAB operon for phosphate uptake is regulated by the global regulator GlxR in Corynebacterium glutamicum.
Starvation
The spatial expression patterns of a phosphate transporter (MtPT1) from Medicago truncatula indicate a role in phosphate transport at the root/soil interface.
Starvation
The SPX domain of the yeast low-affinity phosphate transporter Pho90 regulates transport activity.
Starvation
The Transcription Factor NIGT1.2 Modulates Both Phosphate Uptake and Nitrate Influx during Phosphate Starvation in Arabidopsis and Maize.
Superinfection
Subcellular redistribution of Pit-2 P(i) transporter/amphotropic leukemia virus (A-MuLV) receptor in A-MuLV-infected NIH 3T3 fibroblasts: involvement in superinfection interference.
Tenosynovitis
Immune response to avian reovirus in chickens and protection against experimental infection.
Thymoma
Two Cases of anti-PIT-1 Hypophysitis Exhibited as a Form of Paraneoplastic Syndrome not Associated With Thymoma.
Thyroid Dysgenesis
Association of patent ductus arteriosus and severe hypothyroidism in term newborns: coincidence or causal?
Tuberculosis
A Mycobacterium tuberculosis gene cluster encoding proteins of a phosphate transporter homologous to the Escherichia coli Pst system.
Tuberculosis
B-subunit of phosphate-specific transporter from Mycobacterium tuberculosis is a thermostable ATPase.
Tuberculosis
Crystal structure of M tuberculosis ABC phosphate transport receptor: specificity and charge compensation dominated by ion-dipole interactions.
Tuberculosis
Expression, purification and improved antigenicity of the Mycobacterium tuberculosis PstS1 antigen for serodiagnosis.
Tuberculosis
Identification of a second Mycobacterium tuberculosis gene cluster encoding proteins of an ABC phosphate transporter.
Tuberculosis
Immunogenicity and protective efficacy of tuberculosis DNA vaccines encoding putative phosphate transport receptors.
Tuberculosis
Intrinsic contributions of polar amino acid residues toward thermal stability of an ABC-ATPase of mesophilic origin.
Tuberculosis
Nucleotide-induced conformational change in the catalytic subunit of the phosphate-specific transporter from M. tuberculosis: implications for the ATPase structure.
Uremia
PiT-2, a type III sodium-dependent phosphate transporter, protects against vascular calcification in mice with chronic kidney disease fed a high-phosphate diet.
Urinary Bladder Neoplasms
Overexpression of monocarboxylate anion transporter 1 and 4 in T24-induced cancer-associated fibroblasts regulates the progression of bladder cancer cells in a 3D microfluidic device.
Urinary Tract Infections
The high-affinity phosphate transporter Pst is a virulence factor for Proteus mirabilis during complicated urinary tract infection.
Urolithiasis
Nephrolithiasis and osteoporosis associated with hypophosphatemia caused by mutations in the type 2a sodium-phosphate cotransporter.
Uterine Cervical Neoplasms
Induction of chinook salmon growth hormone promoter activity by the adenosine 3',5'-monophosphate (cAMP)-dependent pathway involves two cAMP-response elements with the CGTCA motif and the pituitary-specific transcription factor Pit-1.
Vascular Calcification
Accelerated atherosclerotic calcification and Monckeberg's sclerosis: a continuum of advanced vascular pathology in chronic kidney disease.
Vascular Calcification
Amplification of atherosclerotic calcification and Mönckeberg's sclerosis: a spectrum of the same disease process.
Vascular Calcification
Calcitriol Accelerates Vascular Calcification Irrespective of Vitamin K Status in a Rat Model of Chronic Kidney Disease with Hyperphosphatemia and Secondary Hyperparathyroidism.
Vascular Calcification
Calcium Overload Accelerates Phosphate-Induced Vascular Calcification Via Pit-1, but not the Calcium-Sensing Receptor.
Vascular Calcification
Dipeptidyl peptidase-4 inhibitor gemigliptin protects against vascular calcification in an experimental chronic kidney disease and vascular smooth muscle cells.
Vascular Calcification
Lanthanum acetate inhibits vascular calcification induced by vitamin D3 plus nicotine in rats.
Vascular Calcification
Magnesium prevents phosphate-induced vascular calcification via TRPM7 and Pit-1 in an aortic tissue culture model.
Vascular Calcification
Novel mechanisms in accelerated vascular calcification in renal disease patients.
Vascular Calcification
Phosphate and vascular calcification: Emerging role of the sodium-dependent phosphate co-transporter PiT-1.
Vascular Calcification
Phosphate uptake-independent signaling functions of the type III sodium-dependent phosphate transporter, PiT-1, in vascular smooth muscle cells.
Vascular Calcification
PiT-2, a type III sodium-dependent phosphate transporter, protects against vascular calcification in mice with chronic kidney disease fed a high-phosphate diet.
Vascular Calcification
Receptor for advanced glycation end products: a key molecule in the genesis of chronic kidney disease vascular calcification and a potential modulator of sodium phosphate co-transporter PIT-1 expression.
Vascular Calcification
Regulation of the Sodium-Phosphate Cotransporter Pit-1 and its Role in Vascular Calcification.
Vascular Calcification
Sodium-Dependent Phosphate Cotransporters and Phosphate-Induced Calcification of Vascular Smooth Muscle Cells: Redundant Roles for PiT-1 and PiT-2.
Vascular Calcification
Sodium-dependent phosphate cotransporters and vascular calcification.
Vascular Calcification
Trichostatin A, an HDAC Class I/II Inhibitor, Promotes Pi-Induced Vascular Calcification Via Up-Regulation of the Expression of Alkaline Phosphatase.
Vascular Calcification
Up-regulation of Cbfa1 and Pit-1 in calcified artery of uraemic rats with severe hyperphosphataemia and secondary hyperparathyroidism.
Vascular Calcification
Using 99mTc-(V)-DMSA to follow the vascular calcification process in vascular smooth muscle cells based on pit-1 expression.
Vascular Calcification
Vascular smooth muscle cell calcification and SLC20 inorganic phosphate transporters: effects of PDGF, TNF-alpha, and Pi.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
SOURCE
endogenous PiT1 mRNA level is decreased in dense MC3T3-E1 cell cultures
brenda
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
malfunction
PiT1 knock-out mice do not survive past E12.5 and from E10.5, the embryos are growth-retarded and show reduced proliferation of liver cells. Isolated mouse embryonic fibroblasts MC3T3-E1 with knocked out as well as reduced PiT1 expression levels also exhibit impaired proliferation
physiological function
a certain level of PiT1 is important for proliferation, role of PiT1 in regulation of cell proliferation, overview
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable).
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable). Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
additional information
additional information
generation of PiT1 knock-out mice and isolated mouse embryonic fibroblasts with PiT1 knockout
additional information
-
generation of PiT1 knock-out mice and isolated mouse embryonic fibroblasts with PiT1 knockout
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Byskov, K.; Jensen, N.; Kongsfelt, I.; Wielsoe, M.; Pedersen, L.; Haldrup, C.; Pedersen, L.
Regulation of cell proliferation and cell density by the inorganic phosphate transporter PiT1
Cell Div.
7
7
2012
Mus musculus (Q61609), Mus musculus, Homo sapiens (Q8WUM9), Homo sapiens
brenda
EXTERNAL LINKS (specific for EC-Number 7.3.2.1)
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
About BRENDA
Social media
Help
Survey
Download
Contribution
Legal
Curated at
Member of
