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Information on EC 7.2.2.8 - P-type Cu+ transporter and Organism(s) Rattus norvegicus and UniProt Accession P70705

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EC Tree
IUBMB Comments
A P-type ATPase that undergoes covalent phosphorylation during the transport cycle. This enzyme transports Cu+ or Ag+, and cannot transport the divalent ions, contrary to EC 7.2.2.9, P-type Cu2+ transporter, which mainly transports the divalent copper ion.
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Rattus norvegicus
UNIPROT: P70705
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The taxonomic range for the selected organisms is: Rattus norvegicus
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea
Synonyms
slc31a1, copt1, ctra2, cu(+)-atpase, copa1, copa2, copper-transporting atpase 2, ctra3, cu atpase, copper export atpase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Cu+-exporting ATPase
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SYSTEMATIC NAME
IUBMB Comments
ATP phosphohydrolase (P-type, Cu+-exporting)
A P-type ATPase that undergoes covalent phosphorylation during the transport cycle. This enzyme transports Cu+ or Ag+, and cannot transport the divalent ions, contrary to EC 7.2.2.9, P-type Cu2+ transporter, which mainly transports the divalent copper ion.
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
SwissProt
Manually annotated by BRENDA team
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
physiological function
ATP7A interacts with IQGAP1, a Rac1 and receptor tyrosine kinase binding scaffolding protein. In cultured rat aortic smooth muscle cells, PDGF stimulation rapidly promotes ATP7A association with IQGAP1 and Rac1 and their translocation to the lipid rafts and leading edge. ATP7A directly binds to NH2-terminal domain of IQGAP1. Both ATP7A or IQGAP1 depletion using siRNA significantly inhibits PDGF-induced vascular smooth muscle cell migration without additive effects
physiological function
Fe uptake and efflux are impaired by Atp7a silencing. Expression of the iron importer Dmt1, apical membrane ferrireductase Dcytb and iron exporter Fpn1 are decreased in Atp7a knockdown cells. Cell-surface ferrireductase activity increases about 5fold in Atp7a knockdown cells despite decreased Dcytb mRNA expression. Increased expression of iron oxidase hephaestin is associated with increased ferroxidase activity in knockdown cells
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
ATP7A_RAT
1492
8
162093
Swiss-Prot
other Location (Reliability: 2)
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Ashino, T.; Kohno, T.; Sudhahar, V.; Ash, D.; Ushio-Fukai, M.; Fukai, T.
Copper transporter ATP7A interacts with IQGAP1, a Rac1 binding scaffold protein role in PDGF-induced VSMC migration and vascular remodeling
Am. J. Physiol. Cell Physiol.
315
C850-C862
2018
Rattus norvegicus (P70705)
Manually annotated by BRENDA team
Ha, J.H.; Doguer, C.; Collins, J.F.
Knockdown of copper-transporting ATPase 1 (Atp7a) impairs iron flux in fully-differentiated rat (IEC-6) and human (Caco-2) intestinal epithelial cells
Metallomics
8
963-972
2016
Rattus norvegicus (D1MCF1), Homo sapiens (Q04656)
Manually annotated by BRENDA team