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IUBMB CommentsA P-type ATPase that undergoes covalent phosphorylation during the transport cycle. This enzyme transports Cu+ or Ag+, and cannot transport the divalent ions, contrary to EC 7.2.2.9, P-type Cu2+ transporter, which mainly transports the divalent copper ion.
Synonyms
slc31a1, copt1, ctra2, cu(+)-atpase, copa1, copa2, copper-transporting atpase 2, ctra3, cu atpase, copper export atpase,
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ATP phosphohydrolase (P-type, Cu+-exporting)
A P-type ATPase that undergoes covalent phosphorylation during the transport cycle. This enzyme transports Cu+ or Ag+, and cannot transport the divalent ions, contrary to EC 7.2.2.9, P-type Cu2+ transporter, which mainly transports the divalent copper ion.
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Alzheimer Disease
The families of zinc (SLC30 and SLC39) and copper (SLC31) transporters.
Breast Neoplasms
Association of drug transporter expression with mortality and progression-free survival in stage IV head and neck squamous cell carcinoma.
Carcinoma
Effects of SLC31A1 and ATP7B polymorphisms on platinum resistance in patients with esophageal squamous cell carcinoma receiving neoadjuvant chemoradiotherapy.
Carcinoma, Ovarian Epithelial
ZNF711 down-regulation promotes CISPLATIN resistance in epithelial ovarian cancer via interacting with JHDM2A and suppressing SLC31A1 expression.
Cardiomyopathies
Copper deficiency and heart disease: molecular basis, recent advances and current concepts.
Cleft Lip
Searching for genes for cleft lip and/or palate based on breakpoint analysis of a balanced translocation t(9;17)(q32;q12).
Colorectal Neoplasms
Transcriptome analysis of copper homeostasis genes reveals coordinated upregulation of SLC31A1,SCO1, and COX11 in colorectal cancer.
Esophageal Neoplasms
Association between ABCC2 polymorphism and hematological toxicity in patients with esophageal cancer receiving platinum plus 5-fluorouracil therapy.
Esophageal Squamous Cell Carcinoma
Effects of SLC31A1 and ATP7B polymorphisms on platinum resistance in patients with esophageal squamous cell carcinoma receiving neoadjuvant chemoradiotherapy.
Glioma
Human marrow stromal cells secrete microRNA-375-containing exosomes to regulate glioma progression.
Infections
The bacterial pathogen Xanthomonas oryzae overcomes rice defenses by regulating host copper redistribution.
Iron Deficiencies
Copper and ectopic expression of the Arabidopsis transport protein COPT1 alter iron homeostasis in rice (Oryza sativa L.).
Liver Neoplasms
Altered copper homeostasis underlies sensitivity of hepatocellular carcinoma to copper chelation.
Lung Neoplasms
A pharmacogenetics study of platinum-based chemotherapy in lung cancer: ABCG2 polymorphism and its genetic interaction with SLC31A1 are associated with response and survival.
Lung Neoplasms
Genetic polymorphism of SLC31A1 is associated with clinical outcomes of platinum-based chemotherapy in non-small-cell lung cancer patients through modulating microRNA-mediated regulation.
Lysosomal Storage Diseases
Accounting for Protein Subcellular Localization: A Compartmental Map of the Rat Liver Proteome.
Neoplasms
Identification of cell surface and secreted proteins essential for tumor cell survival using a genetic suppressor element screen.
Neoplasms
The families of zinc (SLC30 and SLC39) and copper (SLC31) transporters.
Neuroblastoma
Carnosine modulates the Sp1-Slc31a1/Ctr1 copper-sensing system and influences copper homeostasis in murine CNS-derived cells.
Osteosarcoma
PTBP1 modulates osteosarcoma chemoresistance to cisplatin by regulating the expression of the copper transporter SLC31A1.
Ototoxicity
Human OCT2 variant c.808G>T confers protection effect against cisplatin-induced ototoxicity.
Squamous Cell Carcinoma of Head and Neck
Association of drug transporter expression with mortality and progression-free survival in stage IV head and neck squamous cell carcinoma.
Starvation
Cu-sensing transcription factor Mac1 coordinates with the Ctr transporter family to regulate Cu acquisition and virulence in Aspergillus fumigatus.
Starvation
Molecular Characteristics of the Conserved Aspergillus nidulans Transcription Factor Mac1 and Its Functions in Response to Copper Starvation.
Starvation
Molecular characterization of a putative Arabidopsis thaliana copper transporter and its yeast homologue.
Starvation
The Role of Zinc in Copper Homeostasis of Aspergillus fumigatus.
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physiological function
enzyme specifically transports Cu(I) , but Ctr1 peptides bind Cu(II) at an amino terminal high-affinity Cu(II), Ni(II) (ATCUN) site. Ascorbate-dependent reduction of the Cu(II)-high-affinity Cu(II), Ni(II) (ATCUN) site is possible by virtue of an adjacent bis-His motif. Changes in the sequence proximity of the high-affinity site and bis-His motif lead to significant differences in coordination structure and chemical behavior
physiological function
the N-terminus of CTR1 may serve as intermediate binding site during Cu(II) transfer from blood copper carriers to the transporter. Human N-terminal sequence Met-Asp-His, MDH-amide, but not MNH-amide forms a low abundance complex with non-amino terminal Cu(II)- and Ni(II)-binding site coordination involving the Met amine, His imidazole and Asp carboxylate. This species might assist Cu(II) relay down the peptide chain or its reduction to Cu(I), both necessary for the CTR1 function
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Schwab, S.; Shearer, J.; Conklin, S.E.; Alies, B.; Haas, K.L.
Sequence proximity between Cu(II) and Cu(I) binding sites of human copper transporter 1 model peptides defines reactivity with ascorbate and O2
J. Inorg. Biochem.
158
70-76
2016
Homo sapiens (O15431)
brenda
Bossak, K.; Drew, S.C.; Stefaniak, E.; Plonka, D.; Bonna, A.; Bal, W.
The Cu(II) affinity of the N-terminus of human copper transporter CTR1 Comparison of human and mouse sequences
J. Inorg. Biochem.
182
230-237
2018
Homo sapiens (O15431)
brenda