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Information on EC 7.2.2.4 - ABC-type Na+ transporter and Organism(s) Bacillus subtilis and UniProt Accession P46903

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IUBMB Comments
ABC-type (ATP-binding cassette-type) transporter, characterized by the presence of two similar ATP-binding domains/proteins and two integral membrane domains/proteins. This bacterial enzyme, characterized from Bacillus subtilis, exports Na+ ions out of the cell. cf. EC 7.2.2.1, Na+-transporting two-sector ATPase and EC 7.2.2.3, P-type Na+ transporter.
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Bacillus subtilis
UNIPROT: P46903
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The taxonomic range for the selected organisms is: Bacillus subtilis
The expected taxonomic range for this enzyme is: Bacteria
Reaction Schemes
Synonyms
natab, tm0543, natcab, abc-type 2 transporter, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
natAB
SYSTEMATIC NAME
IUBMB Comments
ATP phosphohydrolase (ABC-type, Na+-exporting)
ABC-type (ATP-binding cassette-type) transporter, characterized by the presence of two similar ATP-binding domains/proteins and two integral membrane domains/proteins. This bacterial enzyme, characterized from Bacillus subtilis, exports Na+ ions out of the cell. cf. EC 7.2.2.1, Na+-transporting two-sector ATPase and EC 7.2.2.3, P-type Na+ transporter.
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
ATP + H2O + Na+[side 1]
ADP + phosphate + Na+[side 2]
show the reaction diagram
ATP + H2O + Rb+[side 1]
ADP + phosphate + Rb+[side 2]
show the reaction diagram
-
-
-
?
ATP + H2O + Na+[side 1]
ADP + phosphate + Na+[side 2]
show the reaction diagram
ATP + H2O + Rb+[side 1]
ADP + phosphate + Rb+[side 2]
show the reaction diagram
-
-
-
?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
ATP + H2O + Na+[side 1]
ADP + phosphate + Na+[side 2]
show the reaction diagram
ATP + H2O + Na+[side 1]
ADP + phosphate + Na+[side 2]
show the reaction diagram
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
Ni-affinity column chromatography
Ni-affinity column chromatography
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
expressed in Escherichia coli EP432 cells
expressed in Escherichia coli EP432 cells
EXPRESSION
ORGANISM
UNIPROT
LITERATURE
expression of the operon is induced by ethanol and the carbonylcyanide p-chlorophenylhydrazone, and, more modestly, by Na+, and K+, but not by choline or a high concentration of sucrose
the NatK-NatR response regulator system positively regulates the expression of the enzyme
expression of the operon is induced by ethanol and the carbonylcyanide p-chlorophenylhydrazone, and, more modestly, by Na+, and K+, but not by choline or a high concentration of sucrose
the NatK-NatR response regulator system positively regulates the expression of the enzyme
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Ogura, M.; Tsukahara, K.; Hayashi, K.; Tanaka, T.
The Bacillus subtilis NatK-NatR two-component system regulates expression of the natAB operon encoding an ABC transporter for sodium ion extrusion
Microbiology
153
667-675
2007
Bacillus subtilis (P46903), Bacillus subtilis (P46904), Bacillus subtilis, Bacillus subtilis 168 (P46903), Bacillus subtilis 168 (P46904)
Manually annotated by BRENDA team
Cheng, J.; Guffanti, A.; Krulwich, T.
A two-gene ABC-type transport system that extrudes Na+ in Bacillus subtilis is induced by ethanol or protonophore
Mol. Microbiol.
23
1107-1120
1997
Bacillus subtilis (P46903), Bacillus subtilis (P46904), Bacillus subtilis, Bacillus subtilis BD99 (P46903), Bacillus subtilis BD99 (P46904)
Manually annotated by BRENDA team