Disease on EC 7.2.2.19 - H+/K+-exchanging ATPase
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Achlorhydria
A genetic origin for acid-base imbalance triggers the mitochondrial damage that explains the autoimmune response and drives to gastric neuroendocrine tumours.
Achlorhydria
Helicobacter pylori virulence factors affecting gastric proton pump expression and acid secretion.
Achlorhydria
Hypochlorhydria from short-term omeprazole treatment does not inhibit intestinal absorption of calcium, phosphorus, magnesium or zinc from food in humans.
Achlorhydria
IL-1beta modulation of H,K-ATPase alpha-subunit gene transcription in Helicobacter pylori infection.
Achlorhydria
Mutation of the gastric hydrogen-potassium ATPase alpha subunit causes iron-deficiency anemia in mice.
Achlorhydria
Reciprocal regulation of antral gastrin and somatostatin gene expression by omeprazole-induced achlorhydria.
Achlorhydria
Stomachs of mice lacking the gastric H,K-ATPase alpha -subunit have achlorhydria, abnormal parietal cells, and ciliated metaplasia.
Acidosis
Aldosterone requires vasopressin v1a receptors on intercalated cells to mediate Acid-base homeostasis.
Acidosis
Expression of HKalpha2 protein is increased selectively in renal medulla by chronic hypokalemia.
Acidosis
Extracellular acidosis contracts coronary but neither renal nor mesenteric artery via modulation of H+,K+-ATPase, voltage-gated K+ channels and L-type Ca2+ channels.
Acidosis
H-K-ATPase in distal renal tubular acidosis: urinary tract obstruction, lithium, and amiloride.
Acidosis
Increased CO(2) stimulates K/Rb reabsorption mediated by H-K-ATPase in CCD of potassium-restricted rabbit.
Acidosis
Re-evaluation of the expression of the gastric H,K-ATPase alpha subunit along the rat nephron.
Acidosis
Stimulation of apical H-K-ATPase in intercalated cells of cortical collecting duct with chronic metabolic acidosis.
Acidosis, Renal Tubular
H-K-ATPase in distal renal tubular acidosis: urinary tract obstruction, lithium, and amiloride.
Adenocarcinoma
The role of Sp1 in IL-1beta and H. pylori-mediated regulation of H,K-ATPase gene transcription.
Alkalosis
Effect of low and high potassium diets on H(+)-K(+)-ATPase and Na(+)-K(+)-ATPase activities in the rat inner medullary collecting duct cells.
Alkalosis
Re-evaluation of the expression of the gastric H,K-ATPase alpha subunit along the rat nephron.
Anemia
Monoclonal antibodies specific for the core protein of the beta-subunit of the gastric proton pump (H+/K+ ATPase). An autoantigen targetted in pernicious anaemia.
Anemia, Pernicious
ATPase4A Autoreactivity and Its Association With Autoimmune Phenotypes in the Type 1 Diabetes Genetics Consortium Study.
Anemia, Pernicious
Characterization of antigenic structures in auto-immune atrophic gastritis with pernicious anaemia. The parietal cell H,K-ATPase and the chief cell pepsinogen are the two major antigens.
Anemia, Pernicious
Major parietal cell antigen in autoimmune gastritis with pernicious anemia is the acid-producing H+,K+-adenosine triphosphatase of the stomach.
Anemia, Pernicious
Monoclonal antibodies specific for the core protein of the beta-subunit of the gastric proton pump (H+/K+ ATPase). An autoantigen targetted in pernicious anaemia.
Anemia, Pernicious
Positive correlation between H,K-adenosine triphosphatase autoantibodies and Helicobacter pylori antibodies in patients with pernicious anemia.
Anemia, Pernicious
[Pernicious anaemia--diagnostic benefit of the detection of autoantibodies against intrinsic factor and gastric parietal cells antigen H+/K+ ATPase].
Arthritis
A cumulative effect involving malfunction of the PTH1R and ATP4A genes explains a familial gastric neuroendocrine tumor with hypothyroidism and arthritis.
Arthritis, Rheumatoid
Occurrence of autoantibodies against intrinsic factor, H,K-ATPase, and pepsinogen in atrophic gastritis and rheumatoid arthritis.
Autoimmune Diseases
ATP4A autoimmunity and Helicobacter pylori infection in children with type 1 diabetes.
Autoimmune Diseases
Prevention of autoimmune gastritis in mice requires extra-thymic T-cell deletion and suppression by regulatory T cells.
Autoimmune Diseases
Sequence analysis of the genes encoding for H+/K+-ATPase in autoimmune gastritis.
Bacterial Infections
Increased expression of ATP12A proton pump in cystic fibrosis airways.
Bone Resorption
Omeprazole, a specific inhibitor of H+-K+-ATPase, inhibits bone resorption in vitro.
Brain Injuries
Microglia generate external proton and potassium ion gradients utilizing a member of the H/K ATPase family.
Carcinogenesis
Effect of myeloid differentiation primary response gene 88 on expression profiles of genes during the development and progression of Helicobacter-induced gastric cancer.
Carcinogenesis
Reactivation of Atp4a concomitant with intragenic DNA demethylation for cancer inhibition in a gastric cancer model.
Carcinoid Tumor
Chromogranin A as a useful neuroendocrine marker in patients with autoimmune Addison's disease.
Carcinoid Tumor
ECL-cell carcinoids and carcinoma in patients homozygous for an inactivating mutation in the gastric H(+) K(+) ATPase alpha subunit.
Carcinoma
Epigenetic Study of Esophageal Carcinoma Based on Methylation, Gene Integration and Weighted Correlation Network Analysis.
Carcinoma
Gastric H+/K+-ATPase Expression in Normal Laryngeal Tissue and Laryngeal Carcinoma.
Cholera
Parietal cell hyperstimulation and autoimmune gastritis in cholera toxin transgenic mice.
Contracture
Positive inotropic and negative chronotropic effects of proton pump inhibitors in isolated rat atrium.
Cough
H+/K+-ATPase (proton pump) inhibitors dampen increased cough reflex: more than gastric acid suppression.
Cushing Syndrome
[Long-term suppression of acid secretion with omeprazole use in metastatic gastrinoma]
Cystic Fibrosis
Phosphorylation of S955 at the protein kinase A consensus promotes maturation of the alpha subunit of the colonic H+,K+ -ATPase.
Dermatitis, Phototoxic
Hypericin-induced phototoxicity of human leukemic cell line HL-60 is potentiated by omeprazole, an inhibitor of H+K+-ATPase and 5'-(N,N-dimethyl)-amiloride, an inhibitor of Na+/H+ exchanger.
Dermatitis, Phototoxic
Modulation of the phototoxic effect of hypericin in human leukemia CEM cell line by N-ethylmaleimide, amiloride and omeprazole.
Diabetes Mellitus, Type 1
ATP4A autoimmunity and Helicobacter pylori infection in children with type 1 diabetes.
Diabetes Mellitus, Type 1
ATP4A autoimmunity in pediatric patients with type 1 diabetes and its relationship to blood count, iron metabolism, and vitamin B12.
Diabetes Mellitus, Type 1
ATPase4A Autoreactivity and Its Association With Autoimmune Phenotypes in the Type 1 Diabetes Genetics Consortium Study.
Diphtheria
Diphtheria toxin-mediated ablation of parietal cells in the stomach of transgenic mice.
Gastric Fistula
Antisecretory activity of omeprazole in the conscious gastric fistula cat: comparison with famotidine.
Gastrinoma
[Long-term suppression of acid secretion with omeprazole use in metastatic gastrinoma]
Gastritis
ATP4A autoimmunity and Helicobacter pylori infection in children with type 1 diabetes.
Gastritis
ATPase4A Autoreactivity and Its Association With Autoimmune Phenotypes in the Type 1 Diabetes Genetics Consortium Study.
Gastritis
Autoantibodies Toward ATP4A and ATP4B Subunits of Gastric Proton Pump H+,K+-ATPase Are Reliable Serological Pre-endoscopic Markers of Corpus Atrophic Gastritis.
Gastritis
Autoimmune gastritis: historical antecedents, outstanding discoveries, and unresolved problems.
Gastritis
Autoimmune gastritis: tolerance and autoimmunity to the gastric H+/K+ ATPase (proton pump).
Gastritis
Case Report: CMV Infection and Same Mechanism-Originated Intestinal Inflammation Compatible With Bowel/Crohn's Disease Is Suggested in ATP4A Mutated-Driven Gastric Neuroendocrine Tumors.
Gastritis
Cobalamin, folate, methylmalonic acid, homocysteine, and gastritis markers in dementia.
Gastritis
Direct measurement of gastric H+/K+-ATPase activities in patients with or without Helicobacter pylori-associated chronic gastritis.
Gastritis
Experimental autoimmune gastritis: mouse models of human organ-specific autoimmune disease.
Gastritis
Expression of the gastric H/K-ATPase alpha-subunit in the thymus may explain the dominant role of the beta-subunit in the pathogenesis of autoimmune gastritis.
Gastritis
Growth factors associated with gastric mucosal hypertrophy in autoimmune gastritis.
Gastritis
H(+),K(+)-atpase (proton pump) is the target autoantigen of Th1-type cytotoxic T cells in autoimmune gastritis.
Gastritis
Interferon-gamma is required during the initiation of an organ-specific autoimmune disease.
Gastritis
Luminescent Immunoprecipitation System (LIPS) for Detection of Autoantibodies Against ATP4A and ATP4B Subunits of Gastric Proton Pump H+,K+-ATPase in Atrophic Body Gastritis Patients.
Gastritis
Major parietal cell antigen in autoimmune gastritis with pernicious anemia is the acid-producing H+,K+-adenosine triphosphatase of the stomach.
Gastritis
Molecular mimicry between Helicobacter pylori antigens and H+, K+ --adenosine triphosphatase in human gastric autoimmunity.
Gastritis
Monoclonal antibodies specific for the core protein of the beta-subunit of the gastric proton pump (H+/K+ ATPase). An autoantigen targetted in pernicious anaemia.
Gastritis
Murine autoimmune gastritis and the gastric H,K-ATPase: insights from a new model and autoantibody detection system.
Gastritis
Murine experimental autoimmune gastritis models refractive to development of intrinsic factor autoantibodies, cobalamin deficiency and pernicious anemia.
Gastritis
Organ-specific autoimmunity induced by adult thymectomy and cyclophosphamide-induced lymphopenia.
Gastritis
Prevalence and specificity of antigastric autoantibodies in adolescents infected with Helicobacter pylori.
Gastritis
Prevention of autoimmune gastritis in mice requires extra-thymic T-cell deletion and suppression by regulatory T cells.
Gastritis
Promiscuous thymic expression of an autoantigen gene does not result in negative selection of pathogenic T cells.
Gastritis
Sequence analysis of the genes encoding for H+/K+-ATPase in autoimmune gastritis.
Gastritis
Serum antibodies to H+,K+-ATPase, serum pepsinogen A and Helicobacter pylori in relation to gastric mucosa morphology in patients with low or low-normal concentrations of serum cobalamins.
Gastritis
Spontaneous autoimmune gastritis in C3H/He mice: a new mouse model for gastric autoimmunity.
Gastritis
Structure of the TCR expressed on a gastritogenic T cell clone, II-6, and frequent appearance of similar clonotypes in mice bearing autoimmune gastritis.
Gastritis
The gastric H+,K+-ATPase is a major autoantigen in chronic Helicobacter pylori gastritis with body mucosa atrophy.
Gastritis
The parietal cell autoantigens recognized in neonatal thymectomy-induced murine gastritis are the alpha and beta subunits of the gastric proton pump [corrected]
Gastritis
[Antibodies to H+/K+-ATPase of gastric parietal cells in children with Helicobacter pylori associated chronic gastritis]
Gastritis
[Pernicious anaemia--diagnostic benefit of the detection of autoantibodies against intrinsic factor and gastric parietal cells antigen H+/K+ ATPase].
Gastritis, Atrophic
Autoantibodies Toward ATP4A and ATP4B Subunits of Gastric Proton Pump H+,K+-ATPase Are Reliable Serological Pre-endoscopic Markers of Corpus Atrophic Gastritis.
Gastritis, Atrophic
Characterization of antigenic structures in auto-immune atrophic gastritis with pernicious anaemia. The parietal cell H,K-ATPase and the chief cell pepsinogen are the two major antigens.
Gastritis, Atrophic
H+,K-ATPase antibodies in autoimmune gastritis: observations on the development of pernicious anemia.
Gastritis, Atrophic
Helicobacter pylori eradication induces marked increase in H+/K+-adenosine triphosphatase expression without altering parietal cell number in human gastric mucosa.
Gastritis, Atrophic
Occurrence of autoantibodies against intrinsic factor, H,K-ATPase, and pepsinogen in atrophic gastritis and rheumatoid arthritis.
Gastritis, Atrophic
Serum antibodies to H+,K+-ATPase, serum pepsinogen A and Helicobacter pylori in relation to gastric mucosa morphology in patients with low or low-normal concentrations of serum cobalamins.
Gastroesophageal Reflux
Omeprazole and cytochrome P450-dependent hepatic metabolism: a comparison of endogenous and exogenous substrates in male rats.
Gastroesophageal Reflux
Pantoprazole 20 mg is effective for relief of symptoms and healing of lesions in mild reflux oesophagitis.
Gastroesophageal Reflux
Potassium-competitive acid blockade: a new therapeutic strategy in acid-related diseases.
Gastroesophageal Reflux
Use of vonoprazan for management of systemic sclerosis-related gastroesophageal reflux disease.
Gastroesophageal Reflux
Vonoprazan for treatment of gastroesophageal reflux: pharmacodynamic and pharmacokinetic considerations.
Hypertension
H,K-ATPase type 2 contributes to salt-sensitive hypertension induced by K(+) restriction.
Hypertension
Whole rat DNA array survey for candidate genes related to hypertension in kidneys from three spontaneously hypertensive rat substrains at two stages of age and with hypotensive induction caused by hydralazine hydrochloride.
Hypokalemia
A novel N-terminal splice variant of the rat H+-K+-ATPase alpha2 subunit. Cloning, functional expression, and renal adaptive response to chronic hypokalemia.
Hypokalemia
Expression of HKalpha2 protein is increased selectively in renal medulla by chronic hypokalemia.
Hypokalemia
Mechanism underlying hypokalemia induced by trimethyltin chloride: Inhibition of H+/K+-ATPase in renal intercalated cells.
Hypothyroidism
A cumulative effect involving malfunction of the PTH1R and ATP4A genes explains a familial gastric neuroendocrine tumor with hypothyroidism and arthritis.
Infections
Airway acidification initiates host defense abnormalities in cystic fibrosis mice.
Infections
ATP4A autoimmunity and Helicobacter pylori infection in children with type 1 diabetes.
Infections
Autoimmune gastritis: historical antecedents, outstanding discoveries, and unresolved problems.
Infections
Case Report: CMV Infection and Same Mechanism-Originated Intestinal Inflammation Compatible With Bowel/Crohn's Disease Is Suggested in ATP4A Mutated-Driven Gastric Neuroendocrine Tumors.
Infections
Diversity in bacterium-host interactions within the species Helicobacter heilmannii sensu stricto.
Infections
H,K-ATPase alpha subunit C-terminal membrane topology: epitope tags in the insect cell expression system.
Infections
Helicobacter pylori represses proton pump expression and inhibits acid secretion in human gastric mucosa.
Infections
Helicobacter pylori virulence factors affecting gastric proton pump expression and acid secretion.
Infections
Helicobacter pylori-induced H,K-ATPase {alpha}-subunit gene repression is mediated by NF-{kappa}B p50 homodimer promoter binding.
Infections
Helicobacter pylori-induced posttranscriptional regulation of H-K-ATPase ?-subunit gene expression by miRNA.
Infections
IL-1beta modulation of H,K-ATPase alpha-subunit gene transcription in Helicobacter pylori infection.
Infections
Molecular mimicry in Campylobacter jejuni and Helicobacter pylori lipopolysaccharides: contribution of gastrointestinal infections to autoimmunity.
Insulinoma
The H+/K+ ATPase Inhibitor SCH-28080 Inhibits Insulin Secretion and Induces Cell Death in INS-1E Rat Insulinoma Cells.
Laryngeal Neoplasms
H+/K+ATPase Expression in the Larynx of Laryngopharyngeal Reflux and Laryngeal Cancer Patients.
Laryngopharyngeal Reflux
H+/K+ATPase Expression in the Larynx of Laryngopharyngeal Reflux and Laryngeal Cancer Patients.
Laryngopharyngeal Reflux
New aspects in the pathomechanism and diagnosis of the laryngopharyngeal reflux-clinical impact of laryngeal proton pumps and pharyngeal pH metry in extraesophageal gastroesophageal reflux disease.
Laryngopharyngeal Reflux
Proton pump (H+/K+-ATPase) expression in human laryngeal seromucinous glands.
Meconium Ileus
Genetic association and transcriptome integration identify contributing genes and tissues at cystic fibrosis modifier loci.
Multiple Myeloma
Benzimidazole derivative, BMT-1, induces apoptosis in multiple myeloma cells via a mitochondrial-mediated pathway involving H+/K+-ATPase inhibition.
Myocardial Infarction
Identification and regulation of the gastric H+/K+-ATPase in the rat heart.
Nasal Polyps
Proton pump inhibitors decrease eotaxin-3/CCL26 expression in patients with chronic rhinosinusitis with nasal polyps: Possible role of the nongastric H,K-ATPase.
Neoplasm Metastasis
[Long-term suppression of acid secretion with omeprazole use in metastatic gastrinoma]
Neoplasms
A genetic origin for acid-base imbalance triggers the mitochondrial damage that explains the autoimmune response and drives to gastric neuroendocrine tumours.
Neoplasms
A transgenic mouse model of metastatic carcinoma involving transdifferentiation of a gastric epithelial lineage progenitor to a neuroendocrine phenotype.
Neoplasms
Does long-term profound inhibition of gastric acid secretion increase the risk of ECL cell-derived tumors in man?
Neoplasms
Endoscopic and Pathological Characteristics of Helicobacter pylori Infection-Negative Early Gastric Cancer.
Neoplasms
Expression of the non-gastric H+/K+ ATPase ATP12A in normal and pathological human prostate tissue.
Neoplasms
Gastric achlorhydria in H/K-ATPase-deficient (Atp4a(-/-)) mice causes severe hyperplasia, mucocystic metaplasia and upregulation of growth factors.
Neoplasms
Gastric adenocarcinoma of fundic gland type with signet-ring cell carcinoma component: A case report and review of the literature.
Neoplasms
Intragenic DNA methylation concomitant with repression of ATP4B and ATP4A gene expression in gastric cancer is a potential serum biomarker.
Neoplasms
Metabolism of 20(S)- and 20(R)-ginsenoside Rg3 by human intestinal bacteria and its relation to in vitro biological activities.
Neoplasms
Pantoprazole Induces Mitochondrial Apoptosis and Attenuates NF-?B Signaling in Glioma Cells.
Neoplasms
Prolonged hypergastrinemia does not increase the frequency of colonic neoplasia in patients with Zollinger-Ellison syndrome.
Neoplasms
Reactivation of Atp4a concomitant with intragenic DNA demethylation for cancer inhibition in a gastric cancer model.
Neoplasms
Tumor suppressor ATP4B serve as a promising biomarker for worsening of gastric atrophy and poor differentiation.
Nephritis, Interstitial
Acute Tubulointerstitial Nephritis With an Autoantibody Response Against Carbonic Anhydrase II.
Neuroendocrine Tumors
A cumulative effect involving malfunction of the PTH1R and ATP4A genes explains a familial gastric neuroendocrine tumor with hypothyroidism and arthritis.
Neuroendocrine Tumors
Case Report: CMV Infection and Same Mechanism-Originated Intestinal Inflammation Compatible With Bowel/Crohn's Disease Is Suggested in ATP4A Mutated-Driven Gastric Neuroendocrine Tumors.
Neuroendocrine Tumors
Exome sequencing identifies ATP4A gene as responsible of an atypical familial type I gastric neuroendocrine tumour.
Opportunistic Infections
Case Report: CMV Infection and Same Mechanism-Originated Intestinal Inflammation Compatible With Bowel/Crohn's Disease Is Suggested in ATP4A Mutated-Driven Gastric Neuroendocrine Tumors.
Pancreatic Neoplasms
Proton Pump Inhibitors Reduce Pancreatic Adenocarcinoma Progression by Selectively Targeting H+, K+-ATPases in Pancreatic Cancer and Stellate Cells.
Peptic Ulcer
Omeprazole in the treatment of peptic ulcers resistant to H2-receptor antagonists.
Peptic Ulcer
Omeprazole, a Gastric Proton Pump Inhibitor, Inhibits Melanogenesis by Blocking ATP7A Trafficking.
Peptic Ulcer
Potassium-competitive acid blockade: a new therapeutic strategy in acid-related diseases.
Peptic Ulcer
Potassium-competitive acid blockers: Advanced therapeutic option for acid-related diseases.
Peptic Ulcer
[Effects of gastric proton pump inhibitors on gastric secretion and peptic ulcers]
Peptic Ulcer
[The effects of kampo-formulation and the constituting crude drugs, prescribed for the treatment of peptic ulcer on H,K-ATPase activity]
Pneumonia
ATP4a is required for development and function of the Xenopus mucociliary epidermis - a potential model to study proton pump inhibitor-associated pneumonia.
Prostatic Neoplasms
Expression of the non-gastric H+/K+ ATPase ATP12A in normal and pathological human prostate tissue.
Renal Insufficiency
Ischemic-reperfusion injury in the kidney: overexpression of colonic H+-K+-ATPase and suppression of NHE-3.
Reperfusion Injury
Ischemic-reperfusion injury in the kidney: overexpression of colonic H+-K+-ATPase and suppression of NHE-3.
Stomach Diseases
Autoimmune gastric disease. Chemical and clinical studies with special reference to H+,K+-ATPase.
Stomach Diseases
Revealing the Mechanistic Pathway of Acid Activation of Proton Pump Inhibitors To Inhibit the Gastric Proton Pump: A DFT Study.
Stomach Neoplasms
A genetic origin for acid-base imbalance triggers the mitochondrial damage that explains the autoimmune response and drives to gastric neuroendocrine tumours.
Stomach Neoplasms
A transgenic mouse model of metastatic carcinoma involving transdifferentiation of a gastric epithelial lineage progenitor to a neuroendocrine phenotype.
Stomach Neoplasms
Dietary antioxidants and DNA damage in patients on long-term acid-suppression therapy: a randomized controlled study.
Stomach Neoplasms
Extracellular signal-regulated protein kinases mediate H(+),K(+)-ATPase alpha-subunit gene expression.
Stomach Neoplasms
Hypermethylated long noncoding RNA MEG3 promotes the progression of gastric cancer.
Stomach Neoplasms
Intragenic DNA methylation concomitant with repression of ATP4B and ATP4A gene expression in gastric cancer is a potential serum biomarker.
Stomach Neoplasms
Reactivation of Atp4a concomitant with intragenic DNA demethylation for cancer inhibition in a gastric cancer model.
Stomach Neoplasms
The H+/K+-ATPase inhibitory activities of Trametenolic acid B from Trametes lactinea (Berk.) Pat, and its effects on gastric cancer cells.
Stomach Neoplasms
Tumor suppressor ATP4B serve as a promising biomarker for worsening of gastric atrophy and poor differentiation.
Stomach Ulcer
Effects of NC-1300, a gastric proton pump inhibitor, on healing of acetic acid-induced gastric ulcers in rats.
Stomach Ulcer
Gastroprotective effect of araloside A on ethanol- and aspirin-induced gastric ulcer in mice: involvement of H+/K+-ATPase and mitochondrial-mediated signaling pathway.
Stomach Ulcer
Inhibitory action of omeprazole on acid formation in gastric glands and on H+,K+-ATPase isolated from human gastric mucosa.
Stomach Ulcer
Multipathway Integrated Adjustment Mechanism of Glycyrrhiza Triterpenes Curing Gastric Ulcer in Rats.
Stomach Ulcer
Pantoprazole ameliorates liver fibrosis and suppresses hepatic stellate cell activation in bile duct ligation rats by promoting YAP degradation.
Stomach Ulcer
The Benefit of Passion Fruit as an Anti-ulcerogenic Diet: Scientific Evidence by In-vitro and In-silico H+/K+ATPase Inhibitory Activity Assessment
Ureteral Obstruction
H-K-ATPase in distal renal tubular acidosis: urinary tract obstruction, lithium, and amiloride.
Whooping Cough
Mechanism of activation of ERK and H-K-ATPase by isoproterenol in rat cortical collecting duct.
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