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Information on EC 7.1.2.2 - H+-transporting two-sector ATPase
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7.1.2.2 H+-transporting two-sector ATPaseIUBMB Comments
A multisubunit non-phosphorylated ATPase that is involved in the transport of ions. Large enzymes of mitochondria, chloroplasts and bacteria with a membrane sector (Fo, Vo, Ao) and a cytoplasmic-compartment sector (F1, V1, A1). The F-type enzymes of the inner mitochondrial and thylakoid membranes act as ATP synthases. All of the enzymes included here operate in a rotational mode, where the extramembrane sector (containing 3 alpha- and 3 beta-subunits) is connected via the delta-subunit to the membrane sector by several smaller subunits. Within this complex, the gamma- and epsilon-subunits, as well as the 9--12 c subunits rotate by consecutive 120_degree_ angles and perform parts of ATP synthesis. This movement is driven by the H+ electrochemical potential gradient. The V-type (in vacuoles and clathrin-coated vesicles) and A-type (archaeal) enzymes have a similar structure but, under physiological conditions, they pump H+ rather than synthesize ATP.
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Word Map
- 7.1.2.2
-
acidification
- adp
- bafilomycin
- lysosomal
-
electrochemical
- triphosphate
- beta-subunits
- endosomes
- succinate
-
bioenergetics
- stalk
-
acidify
- osteoclast
- thylakoids
-
submitochondrial
- tubule
-
proteolipids
- resorption
- beef
-
dissipation
- vanadate
-
atp-driven
- mtdna
- acidosis
-
antiporter
-
subcomplexes
- photosystems
-
electrogenic
- mgatp
-
proteoliposomes
- cristae
-
intercalated
-
torque
-
oxphos
-
multisubunit
- presequence
-
chromaffin
-
endomembrane
-
membrane-embedded
-
proton-pumping
-
supercomplexes
-
gamma-subunits
-
ceroid
- valinomycin
-
b-subunits
- adenosinetriphosphatase
- nigericin
-
light-driven
- leigh
- prorenin
- drug development
- synthesis
- molecular biology
- medicine
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea
Synonyms
atp synthase, v-atpase, f1-atpase, h+-atpase, mitochondrial atpase, vacuolar h(+)-atpase, vacuolar atpase, lipid-binding protein, vacuolar h+-atpase, f0f1-atpase, 
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
15 kDa mediatophore protein
-
-
-
-
32 kDa accessory protein
-
-
-
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59 kDa membrane-associated GTP-binding protein
-
-
-
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A6L
-
-
-
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ATP synthase
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-
-
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ATP synthase proteolipid P1
-
-
-
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ATP synthase proteolipid P2
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-
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ATP synthase proteolipid P3
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-
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bacterial Ca2+/Mg2+ ATPase
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-
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BN59
-
-
-
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C7-1 protein
-
-
-
-
CGI-11
-
-
-
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chloroplast ATPase
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-
-
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coupling factors (F0,F1 and CF1)
-
-
-
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Dicyclohexylcarbodiimide-binding protein
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-
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Ductin
-
-
-
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DVA41
-
-
-
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F0F1-ATPase
-
-
-
-
F1-ATPase
-
-
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F1F0 ATPase
-
-
-
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F1F0H+-ATPase
-
-
-
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H+-ATPase
-
-
-
-
H+-translocating ATPase
-
-
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H+-transporting ATPase
-
-
-
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HATPL
-
-
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HO57
-
-
-
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Invasion protein invC
-
-
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Isoform HO68
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-
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Isoform VA68
-
-
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Lipid-binding protein
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-
-
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M40
-
-
-
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mitochondrial ATPase
-
-
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My032 protein
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-
-
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Oligomycin sensitivity conferral protein
-
-
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OSCP
-
-
-
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P31
-
-
-
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P39
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-
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Physophilin
-
-
-
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PKIWI505
-
-
-
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Protein bellwether
-
-
-
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Sul-ATPase alpha
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-
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Sul-ATPase beta
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-
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SUL-ATPase epsilon
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-
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Sul-ATPase gamma
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-
-
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UV-inducible PU4 protein
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-
-
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V-ATPase 28 kDa accessory protein
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-
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V-ATPase 40 kDa accessory protein
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-
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V-ATPase 41 KDa accessory protein
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-
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V-ATPase 9.2 kDa membrane accessory protein
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V-ATPase S1 accessory protein
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-
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VEG100
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VEG31
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Vegetative protein 100
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Vegetative protein 31
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VHA16K
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YOPS secretion ATPase
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-
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-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
hydrolysis of phosphoric ester
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-
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transmembrane transport
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-
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-
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PATHWAY SOURCE
PATHWAYS
BRENDA
-
-
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SYSTEMATIC NAME
IUBMB Comments
ATP phosphohydrolase (H+-transporting)
A multisubunit non-phosphorylated ATPase that is involved in the transport of ions. Large enzymes of mitochondria, chloroplasts and bacteria with a membrane sector (Fo, Vo, Ao) and a cytoplasmic-compartment sector (F1, V1, A1). The F-type enzymes of the inner mitochondrial and thylakoid membranes act as ATP synthases. All of the enzymes included here operate in a rotational mode, where the extramembrane sector (containing 3 alpha- and 3 beta-subunits) is connected via the delta-subunit to the membrane sector by several smaller subunits. Within this complex, the gamma- and epsilon-subunits, as well as the 9--12 c subunits rotate by consecutive 120_degree_ angles and perform parts of ATP synthesis. This movement is driven by the H+ electrochemical potential gradient. The V-type (in vacuoles and clathrin-coated vesicles) and A-type (archaeal) enzymes have a similar structure but, under physiological conditions, they pump H+ rather than synthesize ATP.
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CAS REGISTRY NUMBER
COMMENTARY
9000-83-3
-
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
ADP + phosphate + H+
ATP + H2O
low rates of ATP synthesis
-
-
?
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METALS and IONS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
Ca2+
can function in place of MgCl2, although the affinity is much lower
Mg2+
dependent on
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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
N,N'-dicyclohexylcarbodiimide
0.2 mM can inhibit over 70% of activity after 20 min, which is pH dependent, 50 mM NaCl provides 40% protection against inhibition at pH 7.0, at pH 9.0 1 mM NaCl protects 100%
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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Acidosis
A mouse model for distal renal tubular acidosis reveals a previously unrecognized role of the V-ATPase a4 subunit in the proximal tubule.
Acidosis
A novel heterozygous mutation in the ATP6V0A4 gene encoding the V-ATPase a4 subunit in an adult patient with incomplete distal renal tubular acidosis.
Acidosis
Absence of H(+)-ATPase in cortical collecting tubules of a patient with Sjogren's syndrome and distal renal tubular acidosis.
Acidosis
Absence of vacuolar H(+)-ATPase pump in the collecting duct of a patient with hypokalemic distal renal tubular acidosis and Sjögren's syndrome.
Acidosis
Acidosis-induced V-ATPase trafficking in salivary ducts is initiated by cAMP/PKA/CREB pathway via regulation of Rab11b expression.
Acidosis
Angiostatin is directly cytotoxic to tumor cells at low extracellular pH: a mechanism dependent on cell surface-associated ATP synthase.
Acidosis
Angiotensin II stimulates vacuolar H+ -ATPase activity in renal acid-secretory intercalated cells from the outer medullary collecting duct.
Acidosis
ATP6B1 gene mutations associated with distal renal tubular acidosis and deafness in a child.
Acidosis
Bafilomycin induces the p21-mediated growth inhibition of cancer cells under hypoxic conditions by expressing hypoxia-inducible factor-1alpha.
Acidosis
cAMP stimulates apical V-ATPase accumulation, microvillar elongation, and proton extrusion in kidney collecting duct A-intercalated cells.
Acidosis
Compensatory membrane expression of the V-ATPase B2 subunit isoform in renal medullary intercalated cells of B1-deficient mice.
Acidosis
Coupling factor 6 as a novel vasoactive and proatherogenic peptide in vascular endothelial cells.
Acidosis
Coupling factor 6 enhances the spontaneous microaggregation of platelets by decreasing cytosolic cAMP irrespective of antiplatelet therapy.
Acidosis
Coupling factor 6-induced activation of ecto-F1F(o) complex induces insulin resistance, mild glucose intolerance and elevated blood pressure in mice.
Acidosis
Differential regulation of vacuolar H+ -ATPase subunits by transforming growth factor-?1 in salivary ducts.
Acidosis
Effect of metabolic or respiratory acidosis on rabbit renal medullary proton-ATPase.
Acidosis
Effects of human a3 and a4 mutations that result in osteopetrosis and distal renal tubular acidosis on yeast V-ATPase expression and activity.
Acidosis
Enzymatic and functional evidence for adaptation of the vacuolar H(+)-ATPase in proximal tubule apical membranes from rats with chronic metabolic acidosis.
Acidosis
Functional upregulation of H+-ATPase by lethal acid stress in cultured inner medullary collecting duct cells.
Acidosis
Haploinsufficiency of the Mouse Atp6v1b1 Gene Leads to a Mild Acid-Base Disturbance with Implications for Kidney Stone Disease.
Acidosis
Immunolocalization of vacuolar-type H+-ATPase in rat submandibular gland and adaptive changes induced by acid-base disturbances.
Acidosis
Incomplete distal renal tubular acidosis from a heterozygous mutation of the V-ATPase B1 subunit.
Acidosis
Induction of Phosphoenolpyruvate Carboxykinase (PEPCK) during Acute Acidosis and Its Role in Acid Secretion by V-ATPase-Expressing Ionocytes.
Acidosis
Ischemic preconditioning reduces Na(+) accumulation and cell killing in isolated rat hepatocytes exposed to hypoxia.
Acidosis
Localization and regulation of the ATP6V0A4 (a4) vacuolar H+-ATPase subunit defective in an inherited form of distal renal tubular acidosis.
Acidosis
Mechanisms of toxicity of Cleistanthus collinus: Vacuolar ATPases are a putative target.
Acidosis
Medullary sponge kidney associated with primary distal renal tubular acidosis and mutations of the H+-ATPase genes.
Acidosis
Molecular cloning and characterization of novel tissue-specific isoforms of the human vacuolar H(+)-ATPase C, G and d subunits, and their evaluation in autosomal recessive distal renal tubular acidosis.
Acidosis
Mutations in the gene encoding B1 subunit of H+-ATPase cause renal tubular acidosis with sensorineural deafness.
Acidosis
Myocardial acidosis and the mitigation of tissue ATP depletion in ischemic cardiac muscle: the role of the mitochondrial ATPase.
Acidosis
Nongenomic stimulation of vacuolar H+-ATPases in intercalated renal tubule cells by aldosterone.
Acidosis
Phospholipid changes during adaptation to acidosis in urinary bladder of Bufo marinus.
Acidosis
Preservation of intercalated cell H(+)-ATPase in two patients with lupus nephritis and hyperkalemic distal renal tubular acidosis.
Acidosis
Rab11b and its effector Rip11 regulate the acidosis-induced traffic of V-ATPase in salivary ducts.
Acidosis
Regulation of AE1 anion exchanger and H(+)-ATPase in rat cortex by acute metabolic acidosis and alkalosis.
Acidosis
Regulation of the Proximal Tubule Vacuolar H+-ATPase by PKA and AMP-Activated Protein Kinase.
Acidosis
Relocalization of the V-ATPase B2 subunit to the apical membrane of epididymal clear cells of mice deficient in the B1 subunit.
Acidosis
Renal Atp6ap2/(Pro)renin Receptor Is Required for Normal Vacuolar H+-ATPase Function but Not for the Renin-Angiotensin System.
Acidosis
Roles of vacuolar H+-ATPase in mice treated with norepinephrine and acetylcholine.
Acidosis
Screening and function discussion of a hereditary renal tubular acidosis family pathogenic gene.
Acidosis
Sublethal effects of waterborne copper and copper nanoparticles on the freshwater Neotropical teleost Prochilodus lineatus: A comparative approach.
Acidosis
Systemic lupus erythematosus presenting initially as hydrogen ATPase pump defects of distal renal tubular acidosis.
Acidosis
The Calcineurin inhibitor FK506 (Tacrolimus) is associated with transient metabolic acidosis and altered expression of renal acid-base transport.
Acidosis
The effect of metabolic acidosis and alkalosis on the H+-ATPase of rat cerebral microvessels.
Acidosis
The mechanism underlying the effects of the cell surface ATP synthase on the regulation of intracellular acidification during acidosis.
Acidosis
The vacuolar-ATPase B1 subunit in distal tubular acidosis: novel mutations and mechanisms for dysfunction.
Acidosis
Whole exome sequencing identified ATP6V1C2 as a novel candidate gene for recessive distal renal tubular acidosis.
Acidosis, Lactic
A novel homozygous TMEM70 mutation results in congenital cataract and neonatal mitochondrial encephalo-cardiomyopathy.
Acidosis, Lactic
A previously undescribed leukodystrophy in Leigh syndrome associated with T9176C mutation of the mitochondrial ATPase 6 gene.
Acidosis, Lactic
Common and Novel TMEM70 Mutations in a Cohort of Italian Patients with Mitochondrial Encephalocardiomyopathy.
Acidosis, Lactic
Defective mitochondrial ATPase due to rare mtDNA m.8969G>A mutation-causing lactic acidosis, intellectual disability, and poor growth.
Acidosis, Lactic
Development and characterization of polyspecific anti-mitochondrion antibodies for proteomics studies on in toto tissue homogenates.
Acidosis, Lactic
Mitochondrial encephalocardio-myopathy with early neonatal onset due to TMEM70 mutation.
Acidosis, Lactic
Persistent pulmonary arterial hypertension in the newborn (PPHN): a frequent manifestation of TMEM70 defective patients.
Acidosis, Renal Tubular
A mouse model for distal renal tubular acidosis reveals a previously unrecognized role of the V-ATPase a4 subunit in the proximal tubule.
Acidosis, Renal Tubular
A novel heterozygous mutation in the ATP6V0A4 gene encoding the V-ATPase a4 subunit in an adult patient with incomplete distal renal tubular acidosis.
Acidosis, Renal Tubular
Absence of H(+)-ATPase in cortical collecting tubules of a patient with Sjogren's syndrome and distal renal tubular acidosis.
Acidosis, Renal Tubular
Absence of vacuolar H(+)-ATPase pump in the collecting duct of a patient with hypokalemic distal renal tubular acidosis and Sjögren's syndrome.
Acidosis, Renal Tubular
Angiotensin II stimulates vacuolar H+ -ATPase activity in renal acid-secretory intercalated cells from the outer medullary collecting duct.
Acidosis, Renal Tubular
ATP6B1 gene mutations associated with distal renal tubular acidosis and deafness in a child.
Acidosis, Renal Tubular
Effects of human a3 and a4 mutations that result in osteopetrosis and distal renal tubular acidosis on yeast V-ATPase expression and activity.
Acidosis, Renal Tubular
Haploinsufficiency of the Mouse Atp6v1b1 Gene Leads to a Mild Acid-Base Disturbance with Implications for Kidney Stone Disease.
Acidosis, Renal Tubular
Incomplete distal renal tubular acidosis from a heterozygous mutation of the V-ATPase B1 subunit.
Acidosis, Renal Tubular
Localization and regulation of the ATP6V0A4 (a4) vacuolar H+-ATPase subunit defective in an inherited form of distal renal tubular acidosis.
Acidosis, Renal Tubular
Mechanisms of toxicity of Cleistanthus collinus: Vacuolar ATPases are a putative target.
Acidosis, Renal Tubular
Medullary sponge kidney associated with primary distal renal tubular acidosis and mutations of the H+-ATPase genes.
Acidosis, Renal Tubular
Molecular cloning and characterization of novel tissue-specific isoforms of the human vacuolar H(+)-ATPase C, G and d subunits, and their evaluation in autosomal recessive distal renal tubular acidosis.
Acidosis, Renal Tubular
Mutations in the gene encoding B1 subunit of H+-ATPase cause renal tubular acidosis with sensorineural deafness.
Acidosis, Renal Tubular
Preservation of intercalated cell H(+)-ATPase in two patients with lupus nephritis and hyperkalemic distal renal tubular acidosis.
Acidosis, Renal Tubular
Regulation of the Proximal Tubule Vacuolar H+-ATPase by PKA and AMP-Activated Protein Kinase.
Acidosis, Renal Tubular
Relocalization of the V-ATPase B2 subunit to the apical membrane of epididymal clear cells of mice deficient in the B1 subunit.
Acidosis, Renal Tubular
Renal Atp6ap2/(Pro)renin Receptor Is Required for Normal Vacuolar H+-ATPase Function but Not for the Renin-Angiotensin System.
Acidosis, Renal Tubular
Screening and function discussion of a hereditary renal tubular acidosis family pathogenic gene.
Acidosis, Renal Tubular
Systemic lupus erythematosus presenting initially as hydrogen ATPase pump defects of distal renal tubular acidosis.
Acidosis, Renal Tubular
The vacuolar-ATPase B1 subunit in distal tubular acidosis: novel mutations and mechanisms for dysfunction.
Acidosis, Renal Tubular
V-ATPase Subunit Interactions: The Long Road to Therapeutic Targeting.
Acidosis, Renal Tubular
Whole exome sequencing identified ATP6V1C2 as a novel candidate gene for recessive distal renal tubular acidosis.
Acidosis, Respiratory
Effect of metabolic or respiratory acidosis on rabbit renal medullary proton-ATPase.
Acidosis, Respiratory
Immunolocalization of proton pumps (H+-ATPase) in pavement cells of rainbow trout gill
Acquired Immunodeficiency Syndrome
Allele-specific expression of the Mgi- phenotype on disruption of the F1-ATPase delta-subunit gene in Kluyveromyces lactis.
Acquired Immunodeficiency Syndrome
The curious case of vacuolar ATPase: regulation of signaling pathways.
Acute Kidney Injury
Oligomycin, an F1Fo-ATPase inhibitor, protects against ischemic acute kidney injury in male but not in female rats.
Acute Kidney Injury
Retraction: Oligomycin, an F1FO-ATPase inhibitor, protects against ischemic acute kidney injury in male but not in female rats.
Acute Kidney Injury
Urinary ATP synthase subunit ? is a novel biomarker of renal mitochondrial dysfunction in acute kidney injury.
Adenocarcinoma
Effects of diphyllin as a novel V-ATPase inhibitor on gastric adenocarcinoma.
Adenocarcinoma
Extracellular and Luminal pH Regulation by Vacuolar H+-ATPase Isoform Expression and Targeting to the Plasma Membrane and Endosomes.
Adenocarcinoma
F1F0-ATP Synthase Inhibitory Factor 1 in the Normal Pancreas and in Pancreatic Ductal Adenocarcinoma: Effects on Bioenergetics, Invasion and Proliferation.
Adenocarcinoma
Proton Pump Inhibition Enhances the Cytotoxicity of Paclitaxel in Cervical Cancer.
Adenocarcinoma
Role of the vacuolar H+-ATPase in daunorubicin distribution in etoposide-resistant MCF7 cells overexpressing the multidrug-resistance associated protein.
Adenocarcinoma
The vacuolar-ATPase modulates matrix metalloproteinase isoforms in human pancreatic cancer.
Adenocarcinoma of Lung
Ectopic ATP Synthase Blockade Suppresses Lung Adenocarcinoma Growth by Activating the Unfolded Protein Response.
Adenocarcinoma of Lung
Proteomic analysis of lung adenocarcinoma: identification of a highly expressed set of proteins in tumors.
Adenocarcinoma of Lung
[The expression of ABCG4, V-ATPase and clinic significance of their correlation with NSCLC.]
African Swine Fever
Macrophage cytoplasmic vesicle pH gradients and vacuolar H+-ATPase activities relative to virus infection.
Albinism
Identification of compounds that bind mitochondrial F1F0 ATPase by screening a triazine library for correction of albinism.
Alkalosis
Immunolocalization of vacuolar-type H+-ATPase in rat submandibular gland and adaptive changes induced by acid-base disturbances.
Alkalosis
Regulation of AE1 anion exchanger and H(+)-ATPase in rat cortex by acute metabolic acidosis and alkalosis.
Alkalosis
The effect of metabolic acidosis and alkalosis on the H+-ATPase of rat cerebral microvessels.
Alkalosis
Vacuolar H+-ATPase expression is increased in acid-secreting intercalated cells in kidneys of rats with hypercalcaemia-induced alkalosis.
Alveolar Bone Loss
A novel inhibitor of vacuolar ATPase, FR202126, prevents alveolar bone destruction in experimental periodontitis in rats.
Alzheimer Disease
?-amyloid Peptide Binds and Regulates Ectopic ATP Synthase ?-Chain on Neural Surface.
Alzheimer Disease
Abnormal levels of prohibitin and ATP synthase in the substantia nigra and frontal cortex in Parkinson's disease.
Alzheimer Disease
Anti-ATP Synthase Autoantibodies Induce Neuronal Death by Apoptosis and Impair Cognitive Performance in C57BL/6 Mice.
Alzheimer Disease
Association of ATP synthase alpha-chain with neurofibrillary degeneration in Alzheimer's disease.
Alzheimer Disease
ATP synthase and Alzheimer's disease: putting a spin on the mitochondrial hypothesis.
Alzheimer Disease
Broadening the horizon: Integrative pharmacophore-based and cheminformatics screening of novel chemical modulators of mitochondria ATP synthase towards interventive Alzheimer's disease therapy.
Alzheimer Disease
Cyclophilin D deficiency attenuates mitochondrial F1Fo ATP synthase dysfunction via OSCP in Alzheimer's disease.
Alzheimer Disease
Cytochrome c oxidase and mitochondrial F1F0-ATPase (ATP synthase) activities in platelets and brain from patients with Alzheimer's disease.
Alzheimer Disease
Deciphering the 'Elixir of Life': Dynamic Perspectives into the Allosteric Modulation of Mitochondrial ATP Synthase by J147, a Novel Drug in the Treatment of Alzheimer's Disease.
Alzheimer Disease
Decreased hippocampal metabolic activity in Alzheimer patients is not reflected in the immunoreactivity of cytochrome oxidase subunits.
Alzheimer Disease
Deregulation of mitochondrial F1FO-ATP synthase via OSCP in Alzheimer's disease.
Alzheimer Disease
Disorders of lysosomal acidification-The emerging role of v-ATPase in aging and neurodegenerative disease.
Alzheimer Disease
In Silico Repurposing of J147 for Neonatal Encephalopathy Treatment: Exploring Molecular Mechanisms of Mutant Mitochondrial ATP Synthase.
Alzheimer Disease
Lysosomal TPCN (two pore segment channel) inhibition ameliorates beta-amyloid pathology and mitigates memory impairment in Alzheimer disease.
Alzheimer Disease
Mitochondrial ATP synthase activity is impaired by suppressed O-GlcNAcylation in Alzheimer's disease.
Alzheimer Disease
PSEN2 (presenilin 2) mutants linked to familial Alzheimer disease impair autophagy by altering Ca2+ homeostasis.
Alzheimer Disease
Roles for H+ /K+ -ATPase and zinc transporter 3 in cAMP-mediated lysosomal acidification in bafilomycin A1-treated astrocytes.
Alzheimer Disease
The effect of V-ATPase function defects in pathogenesis of Alzheimer's disease.
Alzheimer Disease
[Functional disorders of FOF1-ATPase in submitochondrial particles obtained from platelets of patients with a diagnosis of probable Alzheimer's disease]
Ameloblastoma
Surface vacuolar ATPase in ameloblastoma contributes to tumor invasion of the jaw bone.
Amyotrophic Lateral Sclerosis
C9orf72 and smcr8 mutant mice reveal MTORC1 activation due to impaired lysosomal degradation and exocytosis.
Amyotrophic Lateral Sclerosis
Dexpramipexole improves bioenergetics and outcome in experimental stroke.
Anemia
IF1, a natural inhibitor of mitochondrial ATP synthase, is not essential for the normal growth and breeding of mice.
Anemia
Sublethal effects of waterborne copper and copper nanoparticles on the freshwater Neotropical teleost Prochilodus lineatus: A comparative approach.
Anemia, Hypochromic
Bicarbonate blocks the expression of several genes involved in the physiological responses to Fe deficiency of Strategy I plants.
Arrhythmias, Cardiac
Left ventricular noncompaction (LVNC) and low mitochondrial membrane potential are specific for Barth syndrome.
Arthritis
FR177995, a novel vacuolar ATPase inhibitor, exerts not only an inhibitory effect on bone destruction but also anti-immunoinflammatory effects in adjuvant-induced arthritic rats.
Arthritis, Rheumatoid
FR177995, a novel vacuolar ATPase inhibitor, exerts not only an inhibitory effect on bone destruction but also anti-immunoinflammatory effects in adjuvant-induced arthritic rats.
Ataxia
A yeast model of the neurogenic ataxia retinitis pigmentosa (NARP) T8993G mutation in the mitochondrial ATP synthase-6 gene.
Ataxia
Antioxidant defence systems and generation of reactive oxygen species in osteosarcoma cells with defective mitochondria: Effect of selenium.
Ataxia
ATP6 homoplasmic mutations inhibit and destabilize the human F1F0-ATP synthase without preventing enzyme assembly and oligomerization.
Ataxia
Correlation between the clinical symptoms and the proportion of mitochondrial DNA carrying the 8993 point mutation in the NARP syndrome.
Ataxia
Defective mitochondrial ATPase due to rare mtDNA m.8969G>A mutation-causing lactic acidosis, intellectual disability, and poor growth.
Ataxia
Defining the impact on yeast ATP synthase of two pathogenic human mitochondrial DNA mutations, T9185C and T9191C.
Ataxia
Disrupted ATP synthase activity and mitochondrial hyperpolarisation-dependent oxidative stress is associated with p66Shc phosphorylation in fibroblasts of NARP patients.
Ataxia
Human NARP mitochondrial mutation metabolism corrected with alpha-ketoglutarate/aspartate: a potential new therapy.
Ataxia
Impaired ATP synthase assembly associated with a mutation in the human ATP synthase subunit 6 gene.
Ataxia
Inefficient coupling between proton transport and ATP synthesis may be the pathogenic mechanism for NARP and Leigh syndrome resulting from the T8993G mutation in mtDNA.
Ataxia
NARP syndrome in a patient harbouring an insertion in the MT-ATP6 gene that results in a truncated protein.
Ataxia
Stability of the m.8993T->G mtDNA mutation load during human embryofetal development has implications for the feasibility of prenatal diagnosis in NARP syndrome.
Ataxia
Superoxide-induced massive apoptosis in cultured skin fibroblasts harboring the neurogenic ataxia retinitis pigmentosa (NARP) mutation in the ATPase-6 gene of the mitochondrial DNA.
Ataxia Telangiectasia
ATP synthase: an identified target gene of bantam in paired female Schistosoma japonicum.
Ataxia Telangiectasia
Defining the impact on yeast ATP synthase of two pathogenic human mitochondrial DNA mutations, T9185C and T9191C.
Atherosclerosis
Ectopic ATP synthase in endothelial cells: a novel cardiovascular therapeutic target.
Atherosclerosis
Genetics and molecular biology: a role for adipocyte lipid-binding protein in atherosclerosis.
Atrial Fibrillation
Specific up-regulation of mitochondrial F0F1-ATPase activity after short episodes of atrial fibrillation in sheep.
Autoimmune Diseases
Conditional Deletion of the V-ATPase a2-Subunit Disrupts Intrathymic T Cell Development.
Autoimmune Diseases
The mtDNA nt7778 G/T polymorphism augments formation of lymphocytic foci but does not aggravate cerulein-induced acute pancreatitis in mice.
Autoimmune Diseases
Visualizing Mitochondrial FoF1-ATP Synthase as the Target of the Immunomodulatory Drug Bz-423.
Autoimmune Pancreatitis
The mtDNA nt7778 G/T polymorphism augments formation of lymphocytic foci but does not aggravate cerulein-induced acute pancreatitis in mice.
Bacterial Infections
Identification of ATP synthase ? subunit as a new maternal factor capable of protecting zebrafish embryos from bacterial infection.
Bacterial Infections
The macrophage-specific V-ATPase subunit ATP6V0D2 restricts inflammasome activation and bacterial infection by facilitating autophagosome-lysosome fusion.
Beriberi
Citreoviridin induces myocardial apoptosis through PPAR-?-mTORC2-mediated autophagic pathway and the protective effect of thiamine and selenium.
Blast Crisis
Down-regulation of mitochondrial ATPase by hypermethylation mechanism in chronic myeloid leukemia is associated with multidrug resistance.
Bone Diseases
A novel inhibitor of vacuolar ATPase, FR167356, which can discriminate between osteoclast vacuolar ATPase and lysosomal vacuolar ATPase.
Bone Diseases
FR177995, a novel vacuolar ATPase inhibitor, exerts not only an inhibitory effect on bone destruction but also anti-immunoinflammatory effects in adjuvant-induced arthritic rats.
Bone Resorption
5-(5,6-Dichloro-2-indolyl)-2-methoxy-2,4-pentadienamides: novel and selective inhibitors of the vacuolar H+-ATPase of osteoclasts with bone antiresorptive activity.
Bone Resorption
A novel inhibitor of vacuolar ATPase, FR167356, which can discriminate between osteoclast vacuolar ATPase and lysosomal vacuolar ATPase.
Bone Resorption
A novel inhibitor of vacuolar ATPase, FR202126, prevents alveolar bone destruction in experimental periodontitis in rats.
Bone Resorption
A pharmacological assessment of the mammalian osteoclast vacuolar H(+)-ATPase.
Bone Resorption
A rationale for osteoclast selectivity of inhibiting the lysosomal V-ATPase a3 isoform.
Bone Resorption
A specific subtype of osteoclasts secretes factors inducing nodule formation by osteoblasts.
Bone Resorption
A vacuolar ATPase inhibitor, FR167356, prevents bone resorption in ovariectomized rats with high potency and specificity: potential for clinical application.
Bone Resorption
Atp6v0d2 is an essential component of the osteoclast-specific proton pump that mediates extracellular acidification in bone resorption.
Bone Resorption
Atp6v1c1 is an essential component of the osteoclast proton pump and in F-actin ring formation in osteoclasts.
Bone Resorption
AZD8835 inhibits osteoclastogenesis and periodontitis-induced alveolar bone loss in rats.
Bone Resorption
Bone resorptive activity of human peripheral blood mononuclear cells after fusion with polyethylene glycol.
Bone Resorption
Bovine parathyroid hormone enhances osteoclast bone resorption by modulating V-ATPase through PTH1R.
Bone Resorption
CD147 promotes the formation of functional osteoclasts through NFATc1 signalling.
Bone Resorption
Characterization and cellular distribution of the osteoclast ruffled membrane vacuolar H+-ATPase B-subunit using isoform-specific antibodies.
Bone Resorption
Concanamycin B, a vacuolar H(+)-ATPase specific inhibitor suppresses bone resorption in vitro.
Bone Resorption
Decreased bone resorption, osteoclast differentiation, and expression of vacuolar H+-ATPase in antisense DNA-treated mouse metacarpal and calvaria cultures ex vivo.
Bone Resorption
Diphyllin, a novel and naturally potent V-ATPase inhibitor, abrogates acidification of the osteoclastic resorption lacunae and bone resorption.
Bone Resorption
Disruption of the V-ATPase Functionality as a Way to Uncouple Bone Formation and Resorption - a Novel Target for Treatment of Osteoporosis.
Bone Resorption
Dissociation of bone resorption and bone formation in adult mice with a non-functional V-ATPase in osteoclasts leads to increased bone strength.
Bone Resorption
Diversity of proton pumps in osteoclasts: V-ATPase with a3 and d2 isoforms is a major form in osteoclasts.
Bone Resorption
Effects of 1?,25-(OH)2D3 on the formation and activity of osteoclasts in RAW264.7 cells.
Bone Resorption
Essential Role of the a3 Isoform of V-ATPase in Secretory Lysosome Trafficking via Rab7 Recruitment.
Bone Resorption
FR177995, a novel vacuolar ATPase inhibitor, exerts not only an inhibitory effect on bone destruction but also anti-immunoinflammatory effects in adjuvant-induced arthritic rats.
Bone Resorption
Glucose-dependent regulation of osteoclast H(+)-ATPase expression: potential role of p38 MAP-kinase.
Bone Resorption
Identification and in silico characterization of a novel p.P208PfsX1 mutation in V-ATPase a3 subunit associated with autosomal recessive osteopetrosis in a Pakistani family.
Bone Resorption
Identification of Enoxacin as an Inhibitor of Osteoclast Formation and Bone Resorption by Structure-Based Virtual Screening.
Bone Resorption
Inhibition of bone resorption in cultures of mouse calvariae by apicularen A.
Bone Resorption
Inhibition of bone resorption in vitro by antisense RNA and DNA molecules targeted against carbonic anhydrase II or two subunits of vacuolar H(+)-ATPase.
Bone Resorption
Inhibition of osteoclast bone resorption by disrupting V-ATPase a3-B2 subunit interaction.
Bone Resorption
Inhibition of osteoclast proton transport by bafilomycin A1 abolishes bone resorption.
Bone Resorption
Interaction of spin-labeled inhibitors of the vacuolar H+-ATPase with the transmembrane Vo-sector.
Bone Resorption
Interstitial collagenase activity stimulates the formation of actin rings and ruffled membranes in mouse marrow osteoclasts.
Bone Resorption
LDC000067 suppresses RANKL-induced osteoclastogenesis in vitro and prevents LPS-induced osteolysis in vivo.
Bone Resorption
Luteolin inhibition of V-ATPase a3-d2 interaction decreases osteoclast resorptive activity.
Bone Resorption
Na+/H(+)-antiporter activity is essential for the induction, but not the maintenance of osteoclastic bone resorption and cytoplasmic spreading.
Bone Resorption
Organization of the biosynthetic gene cluster for the macrolide concanamycin A in Streptomyces neyagawaensis ATCC 27449.
Bone Resorption
Osteoclast proton pump regulator Atp6v1c1 enhances breast cancer growth by activating the mTORC1 pathway and bone metastasis by increasing V-ATPase activity.
Bone Resorption
Osteoclasts express the B2 isoform of vacuolar H(+)-ATPase intracellularly and on their plasma membranes.
Bone Resorption
Osteocytes Acidify Their Microenvironment in Response to PTHrP In Vitro and in Lactating Mice In Vivo.
Bone Resorption
Prevention of wear particle-induced osteolysis by a novel V-ATPase inhibitor saliphenylhalamide through inhibition of osteoclast bone resorption.
Bone Resorption
Prodigiosin 25-C and metacycloprodigiosin suppress the bone resorption by osteoclasts.
Bone Resorption
Proteomic analysis of osteoclast lipid rafts: the role of the integrity of lipid rafts on V-ATPase activity in osteoclasts.
Bone Resorption
Resorptive state and cell size influence intracellular pH regulation in rabbit osteoclasts cultured on collagen-hydroxyapatite films.
Bone Resorption
Specific inhibitors of vacuolar H(+)-ATPase trigger apoptotic cell death of osteoclasts.
Bone Resorption
Suture materials affect peri-implant bone healing and implant osseointegration.
Bone Resorption
The bisphosphonate tiludronate is a potent inhibitor of the osteoclast vacuolar H(+)-ATPase.
Bone Resorption
The mouse osteopetrotic grey-lethal mutation induces a defect in osteoclast maturation/function.
Bone Resorption
The V-ATPase a3 Subunit: Structure, Function and Therapeutic Potential of an Essential Biomolecule in Osteoclastic Bone Resorption.
Bone Resorption
The vacuolar ATPase in bone cells: a potential therapeutic target in osteoporosis.
Bone Resorption
Three subunit a isoforms of mouse vacuolar H(+)-ATPase. Preferential expression of the a3 isoform during osteoclast differentiation.
Bone Resorption
V-ATPase a3 isoform mutations identified in osteopetrosis patients abolish its expression and disrupt osteoclast function.
Bone Resorption
V-ATPase subunit ATP6AP1 (Ac45) regulates osteoclast differentiation, extracellular acidification, lysosomal trafficking, and protease exocytosis in osteoclast-mediated bone resorption.
Bone Resorption
Vacuolar-type H+-ATPase-mediated acidosis promotes in vitro osteoclastogenesis via modulation of cell migration.
Bone Resorption
Vacuolar-type proton pump ATPases: Acidification and pathological relationships.
Bone Resorption
[3H]Bafilomycin as a probe for the transmembrane proton channel of the osteoclast vacuolar H(+)-ATPase.
Bone Resorption
[V-ATPase inhibitor baflomycine A1 inhibits bone resorption by osteoclast-like cells]
Brain Diseases
De novo mutations of the ATP6V1A gene cause developmental encephalopathy with epilepsy.
Brain Diseases
F1F0 ATP Synthase-Cyclophilin D Interaction Contributes to Diabetes-Induced Synaptic Dysfunction and Cognitive Decline.
Brain Diseases
In Silico Repurposing of J147 for Neonatal Encephalopathy Treatment: Exploring Molecular Mechanisms of Mutant Mitochondrial ATP Synthase.
Brain Injuries
Dexpramipexole Enhances K+ Currents and Inhibits Cell Excitability in the Rat Hippocampus In Vitro.
Brain Injuries
Mild hypothermia attenuates post-resuscitation brain injury through a V-ATPase mechanism in a rat model of cardiac arrest.
Brain Injuries, Traumatic
Caffeine administration alters the behaviour and development of Galleria mellonella larvae.
Breast Neoplasms
AGPAT9 suppresses cell growth, invasion and metastasis by counteracting acidic tumor microenvironment through KLF4/LASS2/V-ATPase signaling pathway in breast cancer.
Breast Neoplasms
ATP synthase ecto-?-subunit: a novel therapeutic target for breast cancer.
Breast Neoplasms
Biomarkers of phenethyl isothiocyanate-mediated mammary cancer chemoprevention in a clinically relevant mouse model.
Breast Neoplasms
Bovine Milk Lactoferrin Selectively Kills Highly Metastatic Prostate Cancer PC-3 and Osteosarcoma MG-63 Cells In Vitro.
Breast Neoplasms
Breast cancer associated a2 isoform vacuolar ATPase immunomodulates neutrophils: potential role in tumor progression.
Breast Neoplasms
Cell surface F1/FO ATP synthase contributes to interstitial flow-mediated development of the acidic microenvironment in tumor tissues.
Breast Neoplasms
CERS2 suppresses tumor cell invasion and is associated with decreased V-ATPase and MMP-2/MMP-9 activities in breast cancer.
Breast Neoplasms
Cluster of differentiation 147 mediates chemoresistance in breast cancer by affecting vacuolar H+-ATPase expression and activity.
Breast Neoplasms
Combination therapy targeting ectopic ATP synthase and 26S proteasome induces ER stress in breast cancer cells.
Breast Neoplasms
Distribution of the ATPase inhibitor proteins of mitochondria in mammalian tissues including fibroblasts from a patient with Luft's disease.
Breast Neoplasms
DMXL2 drives epithelial to mesenchymal transition in hormonal therapy resistant breast cancer through Notch hyper-activation.
Breast Neoplasms
Effect of a V-ATPase inhibitor, FR202126, in syngeneic mouse model of experimental bone metastasis.
Breast Neoplasms
Effects of Vacuolar H(+)-ATPase Inhibition on Activation of Cathepsin B and Cathepsin L Secreted from MDA-MB231 Breast Cancer Cells.
Breast Neoplasms
Elevated V-ATPase Activity Following PTEN Loss Is Required for Enhanced Oncogenic Signaling in Breast Cancer.
Breast Neoplasms
Function of a subunit isoforms of the V-ATPase in pH homeostasis and In Vitro invasion of MDA-MB231 human breast cancer cells.
Breast Neoplasms
Function of V-ATPase a Subunit Isoforms in Invasiveness of MCF10a and MCF10CA1a Human Breast Cancer Cells.
Breast Neoplasms
Hematopoietic stem cell specific V-ATPase controls breast cancer progression and metastasis via cytotoxic T cells.
Breast Neoplasms
Identification of Novel Bisbenzimidazole Derivatives as Anticancer Vacuolar (H?)-ATPase Inhibitors.
Breast Neoplasms
Inhibition of pH regulation as a therapeutic strategy in hypoxic human breast cancer cells.
Breast Neoplasms
Isoform-specific gene disruptions reveal a role for the V-ATPase subunit a4 isoform in the invasiveness of 4T1-12B breast cancer cells.
Breast Neoplasms
Lactoferrin selectively triggers apoptosis in highly metastatic breast cancer cells through inhibition of plasmalemmal V-H+-ATPase.
Breast Neoplasms
LASS2 enhances chemosensitivity of breast cancer by counteracting acidic tumor microenvironment through inhibiting activity of V-ATPase proton pump.
Breast Neoplasms
LASS2/TMSG1 inhibits growth and invasion of breast cancer cell in vitro through regulation of vacuolar ATPase activity.
Breast Neoplasms
Mammary epithelium-specific inactivation of V-ATPase reduces stiffness of extracellular matrix and enhances metastasis of breast cancer.
Breast Neoplasms
Molecular cloning and characterization of a novel V-ATPase associated protein, DVA9.2, from human dendritic cells.
Breast Neoplasms
Novel mitochondrial mutations in the ATP6 and ATP8 genes in patients with breast cancer.
Breast Neoplasms
Osteoclast proton pump regulator Atp6v1c1 enhances breast cancer growth by activating the mTORC1 pathway and bone metastasis by increasing V-ATPase activity.
Breast Neoplasms
pH and drug resistance. I. Functional expression of plasmalemmal V-type H+-ATPase in drug-resistant human breast carcinoma cell lines.
Breast Neoplasms
Pharmacologic inhibition of vacuolar H+ ATPase reduces physiologic and oncogenic Notch signaling.
Breast Neoplasms
Rational design for heterologous production of aurovertin-type compounds in Aspergillus nidulans.
Breast Neoplasms
Regulation of V-ATPase Assembly in Nutrient Sensing and Function of V-ATPases in Breast Cancer Metastasis.
Breast Neoplasms
Silencing of TMSG1 enhances metastasis capacity by targeting V-ATPase in breast cancer.
Breast Neoplasms
Small interfering RNA targeting the subunit ATP6L of proton pump V-ATPase overcomes chemoresistance of breast cancer cells.
Breast Neoplasms
T cell immune regulator 1 is a prognostic marker associated with immune infiltration in glioblastoma multiforme.
Breast Neoplasms
Targeting Therapy for Breast Carcinoma by ATP Synthase Inhibitor Aurovertin B.
Breast Neoplasms
The a3 isoform of subunit a of the vacuolar ATPase localizes to the plasma membrane of invasive breast tumor cells and is overexpressed in human breast cancer.
Breast Neoplasms
The V-ATPase a2 isoform controls mammary gland development through Notch and TGF-? signaling.
Breast Neoplasms
The V-ATPase-inhibitor Archazolid abrogates tumor metastasis via inhibition of endocytic activation of the Rho-GTPase Rac1.
Breast Neoplasms
The Vacuolar ATPase a2-subunit regulates Notch signaling in triple-negative breast cancer cells.
Breast Neoplasms
Upregulation of V-ATPase by STAT3 Activation Promotes Anoikis Resistance and Tumor Metastasis.
Breast Neoplasms
Vacuolar ATPase driven potassium transport in highly metastatic breast cancer cells.
Breast Neoplasms
Vacuolar H+ ATPase expression and activity is required for Rab27B-dependent invasive growth and metastasis of breast cancer.
Breast Neoplasms
Vacuolar H+-ATPase in human breast cancer cells with distinct metastatic potential: distribution and functional activity.
Breast Neoplasms
Vacuolar-ATPase Inhibition Blocks Iron Metabolism to Mediate Therapeutic Effects in Breast Cancer.
Carcinogenesis
Association of cancer metabolism-related proteins with oral carcinogenesis - indications for chemoprevention and metabolic sensitizing of oral squamous cell carcinoma?
Carcinogenesis
Elevated V-ATPase Activity Following PTEN Loss Is Required for Enhanced Oncogenic Signaling in Breast Cancer.
Carcinogenesis
Frequent mutations of genes encoding vacuolar H+ -ATPase components in granular cell tumors.
Carcinogenesis
Monitoring of dynamic ATP level changes by oligomycin-modulated ATP synthase inhibition in SW480 cancer cells using fluorescent "On-Off" switching DNA aptamer.
Carcinogenesis
POLR2F, ATP6V0A1 and PRNP expression in colorectal cancer: new molecules with prognostic significance?
Carcinogenesis
Pyruvate kinase M2 and the mitochondrial ATPase Inhibitory Factor 1 provide novel biomarkers of dermatomyositis: a metabolic link to oncogenesis.
Carcinogenesis
Reprogramming Oxidative Phosphorylation in Cancer: A Role for RNA-Binding Proteins.
Carcinogenesis
TGF-beta during human colorectal carcinogenesis: the shift from epithelial to mesenchymal signaling.
Carcinogenesis
The phosphoprotein StarD10 is overexpressed in breast cancer and cooperates with ErbB receptors in cellular transformation.
Carcinogenesis
TMEM9 promotes intestinal tumorigenesis through vacuolar-ATPase-activated Wnt/?-catenin signalling.
Carcinogenesis
Tumor-specific overexpression of a novel keratinocyte lipid-binding protein. Identification and characterization of a cloned sequence activated during multistage carcinogenesis in mouse skin.
Carcinogenesis
Two mutations in mitochondrial ATP6 gene of ATP synthase, related to human cancer, affect ROS, calcium homeostasis and mitochondrial permeability transition in yeast.
Carcinogenesis
V-ATPase controls tumor growth and autophagy in a Drosophila model of gliomagenesis.
Carcinoma
A novel fatty acid-binding protein 5-estrogen-related receptor ? signaling pathway promotes cell growth and energy metabolism in prostate cancer cells.
Carcinoma
Alteration of the bioenergetic phenotype of mitochondria is a hallmark of breast, gastric, lung and oesophageal cancer.
Carcinoma
Antimetastatic effect of a small-molecule vacuolar H+-ATPase inhibitor in in vitro and in vivo preclinical studies.
Carcinoma
Application of high-performance liquid chromatography-based analysis of DNA fragments to molecular carcinogenesis.
Carcinoma
Aurora Kinase A Activates the Vacuolar H+-ATPase (V-ATPase) in Kidney Carcinoma Cells.
Carcinoma
Chemoresistance to concanamycin A1 in human oral squamous cell carcinoma is attenuated by an HDAC inhibitor partly via suppression of Bcl-2 expression.
Carcinoma
Detection of cathepsin B up-regulation in neoplastic thyroid tissues by proteomic analysis.
Carcinoma
Down-regulation of mitochondrial F1F0-ATP synthase in human colon cancer cells with induced 5-fluorouracil resistance.
Carcinoma
Efficient execution of cell death in non-glycolytic cells requires the generation of ROS controlled by the activity of mitochondrial H+-ATP synthase.
Carcinoma
Elevated expression of the V-ATPase C subunit triggers JNK-dependent cell invasion and overgrowth in a Drosophila epithelium.
Carcinoma
Expression of 16 kDa proteolipid of vacuolar-type H(+)-ATPase in human pancreatic cancer.
Carcinoma
High glucose uptake unexpectedly is accompanied by high levels of the mitochondrial ß-F1-ATPase subunit in head and neck squamous cell carcinoma.
Carcinoma
Identification of Differentially Expressed Genes Involved in the Formation of Multicellular Tumor Spheroids by HT-29 Colon Carcinoma Cells.
Carcinoma
Identification of tumor-associated proteins in oral tongue squamous cell carcinoma by proteomics.
Carcinoma
Intracellular pH regulation in oral squamous cell carcinoma is mediated by increased V-ATPase activity via over-expression of the ATP6V1C1 gene.
Carcinoma
Loss of the mitochondrial bioenergetic capacity underlies the glucose avidity of carcinomas.
Carcinoma
Low energy costs of F1Fo ATP synthase reversal in colon carcinoma cells deficient in mitochondrial complex IV.
Carcinoma
Mitochondria-mediated energy adaption in cancer: The H+-ATP synthase-geared switch of metabolism in human tumors.
Carcinoma
Multi-cancer V-ATPase molecular signatures: A distinctive balance of subunit C isoforms in esophageal carcinoma.
Carcinoma
Overexpression of Mitochondrial IF1 Prevents Metastatic Disease of Colorectal Cancer by Enhancing Anoikis and Tumor Infiltration of NK Cells.
Carcinoma
Overexpression of the ATPase Inhibitory Factor 1 Favors a Non-metastatic Phenotype in Breast Cancer.
Carcinoma
pH and drug resistance. I. Functional expression of plasmalemmal V-type H+-ATPase in drug-resistant human breast carcinoma cell lines.
Carcinoma
Prognostic significance and function of the vacuolar H+-ATPase subunit V1E1 in esophageal squamous cell carcinoma.
Carcinoma
Proton pump inhibitors enhance the effects of cytotoxic agents in chemoresistant epithelial ovarian carcinoma.
Carcinoma
Reprogramming Oxidative Phosphorylation in Cancer: A Role for RNA-Binding Proteins.
Carcinoma
Silencing of a novel tumor metastasis suppressor gene LASS2/TMSG1 promotes invasion of prostate cancer cell in vitro through increase of vacuolar ATPase activity.
Carcinoma
Silencing of LASS2/TMSG1 enhances invasion and metastasis capacity of prostate cancer cell.
Carcinoma
Silencing of vacuolar ATPase c subunit ATP6V0C inhibits the invasion of prostate cancer cells through a LASS2/TMSG1-independent manner.
Carcinoma
Systematic Analysis of the Expression of the Mitochondrial ATP Synthase (Complex V) Subunits in Clear Cell Renal Cell Carcinoma.
Carcinoma
The Mitochondrial ATPase Inhibitory Factor 1 Triggers a ROS-Mediated Retrograde Prosurvival and Proliferative Response.
Carcinoma
The Molecular Motor F-ATP Synthase Is Targeted by the Tumoricidal Protein HAMLET.
Carcinoma
Up-regulated expression of the MAT-8 gene in prostate cancer and its siRNA-mediated inhibition of expression induces a decrease in proliferation of human prostate carcinoma cells.
Carcinoma
[Effect of protein inhibitors of mitochondrial ATPase in intact rat thymocytes and Ehrlich ascites carcinoma cells]
Carcinoma
[LASS2/TMSG1 gene silencing promotes the invasiveness and metastatic of human prostatic carcinoma cells through increase in vacuolar ATPase activity].
Carcinoma
[Preparation of monoclonal antibody against lung cancer and identification of its targeting antigen]
Carcinoma in Situ
Polarization of the vacuolar adenosine triphosphatase delineates a transition to high-grade pancreatic intraepithelial neoplasm lesions.
Carcinoma in Situ
The vacuolar-ATPase modulates matrix metalloproteinase isoforms in human pancreatic cancer.
Carcinoma, Ehrlich Tumor
Bioflavonoid regulation of ATPase and hexokinase activity in Ehrlich ascites cell mitochondria.
Carcinoma, Ehrlich Tumor
On the mechanism of glycolysis stimulation by neutral detergents in 3T3 and Ehrlich ascites tumor cells.
Carcinoma, Ehrlich Tumor
Stimulation of glycolysis by placental polypeptides and inhibition by duramycin.
Carcinoma, Hepatocellular
Antisense of ATP synthase subunit e inhibits the growth of human hepatocellular carcinoma cells.
Carcinoma, Hepatocellular
Coupling between proteolytic processing and translocation of the precursor of the F1-ATPase beta-subunit during its import into mitochondria of intact cells.
Carcinoma, Hepatocellular
Data of enzymatic activities of the electron transport chain and ATP synthase complexes in mouse hepatoma cells following exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD).
Carcinoma, Hepatocellular
Different sensitivity of Zajdela hepatoma mitochondrial ATPase activity to uncouplers in digitonin-treated cells and isolated mitochondria.
Carcinoma, Hepatocellular
ETS transcription factors regulate the expression of the gene for the human mitochondrial ATP synthase beta-subunit.
Carcinoma, Hepatocellular
Expression and functional role of vacuolar H+-ATPase in human hepatocellular carcinoma.
Carcinoma, Hepatocellular
In vitro transport of F1-ATPase beta-subunit into mitochondria of Zajdela hepatoma and rat liver.
Carcinoma, Hepatocellular
Increased steady-state levels of several mitochondrial and nuclear gene transcripts in rat hepatoma with a low content of mitochondria.
Carcinoma, Hepatocellular
Membranous effects on adenosine triphosphatase activities of mitochondria from rat liver and Morris hepatoma 3924A.
Carcinoma, Hepatocellular
Mitochondrial ATPase activities of hepatoma BW7756 and ascites tumor cells. Influence of MG2+ ions, free fatty acids, and uncouplers.
Carcinoma, Hepatocellular
Mitochondrial ATPase of Zajdela hepatoma. II. Mitochondria of Zajdela hepatoma contain less adenosine triphosphatase than mitochondria of rat liver.
Carcinoma, Hepatocellular
Mitochondrial ATPase of Zajdela hepatoma. Presence of F1-specific antigenic determinants outside mitochondria.
Carcinoma, Hepatocellular
Mitochondrial ATPase of Zajdela hepatoma. V. Mitochondria of Zajdela hepatoma contain membrane sectors of ATPase complex unassociated with F1.
Carcinoma, Hepatocellular
Mitochondrial ATPase of Zajdela hepatoma. VI. Effect of extramitochondrial ATP and pH on uncoupler-sensitivity of mitochondrial ATPase activity.
Carcinoma, Hepatocellular
New High-throughput Screen Identifies Compounds That Reduce Viability Specifically In Liver Cancer Cells That Express High Levels of SALL4 by Inhibiting Oxidative Phosphorylation.
Carcinoma, Hepatocellular
Overexpression of the inhibitor protein IF(1) in AS-30D hepatoma produces a higher association with mitochondrial F(1)F(0) ATP synthase compared to normal rat liver: functional and cross-linking studies.
Carcinoma, Hepatocellular
Oxidative phosphorylation and F(O)F(1) ATP synthase activity of human hepatocellular carcinoma.
Carcinoma, Hepatocellular
Photosensitization of mitochondrial adenosine-triphosphatase and adenylate kinase by hematoporphyrin derivative in vitro.
Carcinoma, Hepatocellular
Response of mitochondrial ATPase activity to uncouplers in isolated organelles and whole cells of Zajdela hepatoma.
Carcinoma, Hepatocellular
Role of V-ATPases in solid tumors: Importance of the subunit C (Review).
Carcinoma, Hepatocellular
T cell immune regulator 1 is a prognostic marker associated with immune infiltration in glioblastoma multiforme.
Carcinoma, Hepatocellular
The asialoglycoprotein receptor suppresses the metastasis of hepatocellular carcinoma via LASS2-mediated inhibition of V-ATPase activity.
Carcinoma, Hepatocellular
The effect of the natural protein inhibitor on H+-ATPase hepatoma 22a mitochondria.
Carcinoma, Hepatocellular
The inhibitor protein (IF1) promotes dimerization of the mitochondrial F1F0-ATP synthase.
Carcinoma, Hepatocellular
[LASS2 interacts with V-ATPase and inhibits cell growth of hepatocellular carcinoma]
Carcinoma, Hepatocellular
[Photodynamic action of hypocrellin A on hepatoma cell mitochondria and microsomes]
Carcinoma, Non-Small-Cell Lung
Identification of ATP synthase beta subunit (ATPB) on the cell surface as a non-small cell lung cancer (NSCLC) associated antigen.
Carcinoma, Non-Small-Cell Lung
MicroRNA-7-5p's role in the O-GlcNAcylation and cancer metabolism.
Carcinoma, Non-Small-Cell Lung
Silencing of secretory clusterin sensitizes NSCLC cells to V-ATPase inhibitors by downregulating survivin.
Carcinoma, Ovarian Epithelial
Proton pump inhibitors enhance the effects of cytotoxic agents in chemoresistant epithelial ovarian carcinoma.
Carcinoma, Papillary
Detection of cathepsin B up-regulation in neoplastic thyroid tissues by proteomic analysis.
Carcinoma, Renal Cell
Application of high-performance liquid chromatography-based analysis of DNA fragments to molecular carcinogenesis.
Carcinoma, Renal Cell
Systematic Analysis of the Expression of the Mitochondrial ATP Synthase (Complex V) Subunits in Clear Cell Renal Cell Carcinoma.
Carcinoma, Squamous Cell
High glucose uptake unexpectedly is accompanied by high levels of the mitochondrial ß-F1-ATPase subunit in head and neck squamous cell carcinoma.
Cardiomegaly
Role of copper in mitochondrial biogenesis via interaction with ATP synthase and cytochrome c oxidase.
Cardiomyopathies
A novel homozygous TMEM70 mutation results in congenital cataract and neonatal mitochondrial encephalo-cardiomyopathy.
Cardiomyopathies
Common and Novel TMEM70 Mutations in a Cohort of Italian Patients with Mitochondrial Encephalocardiomyopathy.
Cardiomyopathies
Infantile cardiomyopathy caused by a mutation in the overlapping region of mitochondrial ATPase 6 and 8 genes.
Cardiomyopathies
Kinetic properties of mitochondrial ATPase during isoproterenol-induced cardiomyopathy.
Cardiomyopathies
Regulation of the mitochondrial ATP synthase is defective in rat heart during alcohol-induced cardiomyopathy.
Cardiomyopathy, Hypertrophic
Persistent pulmonary arterial hypertension in the newborn (PPHN): a frequent manifestation of TMEM70 defective patients.
Cardiotoxicity
Optimizing Bedaquiline for cardiotoxicity by structure based virtual screening, DFT analysis and molecular dynamic simulation studies to identify selective MDR-TB inhibitors.
Cardiovascular Diseases
Proteomic analysis of right and left cardiac ventricles under aerobic conditions and after ischemia/reperfusion.
Cardiovascular Diseases
The ATP synthase glycine zipper of the c subunits: From the structural to the functional role in mitochondrial biology of cardiovascular diseases.
Celiac Disease
Regulated traffic of anion transporters in mammalian Brunner's glands: a role for water and fluid transport.
Chagas Disease
Heart FoF1-ATPase changes during the acute phase of Trypanosoma cruzi infection in rats.
Chagas Disease
The process of lipid storage in insect oocytes: The involvement of ?-chain of ATP synthase in lipophorin-mediated lipid transfer in the chagas' disease vector Panstrongylus megistus (Hemiptera: Reduviidae).
Cherubism
Multinucleated giant cells in various forms of giant cell containing lesions of the jaws express features of osteoclasts.
Cholera
Role of receptor-mediated endocytosis, endosomal acidification and cathepsin D in cholera toxin cytotoxicity.
Cholestasis
The ectopic F(O)F(1) ATP synthase of rat liver is modulated in acute cholestasis by the inhibitor protein IF1.
Cholestasis
The synthesis of taurocholic and glycocholic acids in human liver homogenates and subcellular fractions in obstructive jaundice.
Choriocarcinoma
The N-terminus domain of the a2 isoform of vacuolar ATPase can regulate interleukin-1beta production from mononuclear cells in co-culture with JEG-3 choriocarcinoma cells.
Colonic Neoplasms
AMPK and GCN2-ATF4 signal the repression of mitochondria in colon cancer cells.
Colonic Neoplasms
Down-regulation of mitochondrial F1F0-ATP synthase in human colon cancer cells with induced 5-fluorouracil resistance.
Colonic Neoplasms
Efficient execution of cell death in non-glycolytic cells requires the generation of ROS controlled by the activity of mitochondrial H+-ATP synthase.
Colonic Neoplasms
Identification of mitochondrial F(1)F(0)-ATP synthase interacting with galectin-3 in colon cancer cells.
Colonic Neoplasms
Identification of mitochondrial FoF1-ATP synthase involved in liver metastasis of colorectal cancer.
Colonic Neoplasms
TM9SF4 is a novel V-ATPase-interacting protein that modulates tumor pH alterations associated with drug resistance and invasiveness of colon cancer cells.
Colorectal Neoplasms
Analysis of metastasis associated signal regulatory network in colorectal cancer.
Colorectal Neoplasms
ATP Synthase Subunit Epsilon Overexpression Promotes Metastasis by Modulating AMPK Signaling to Induce Epithelial-to-Mesenchymal Transition and Is a Poor Prognostic Marker in Colorectal Cancer Patients.
Colorectal Neoplasms
Bcl-2-dependent synthetic lethal interaction of the IDF-11774 with the V0 subunit C of vacuolar ATPase (ATP6V0C) in colorectal cancer.
Colorectal Neoplasms
Cell surface F1-ATPase binds the Gastrin precursor, G-gly, and mediates its proliferative effects on colorectal cancer cells and vascular endothelial cells.
Colorectal Neoplasms
Down-regulation of mitochondrial F1F0-ATP synthase in human colon cancer cells with induced 5-fluorouracil resistance.
Colorectal Neoplasms
Identification of mitochondrial FoF1-ATP synthase involved in liver metastasis of colorectal cancer.
Colorectal Neoplasms
Inhibition of vacuolar ATPase attenuates the TRAIL-induced activation of caspase-8 and modulates the trafficking of TRAIL receptosomes.
Colorectal Neoplasms
Oligomycin A promotes radioresistance in HT29 colorectal cancer cells and its mechanisms.
Colorectal Neoplasms
Vacuolar Membrane ATPase Activity 21 Predicts a Favorable Outcome and Acts as a Suppressor in Colorectal Cancer.
Congenital, Hereditary, and Neonatal Diseases and Abnormalities
sMutations in the V-ATPase assembly factor VMA21 cause a congenital disorder of glycosylation with autophagic liver disease.
Contracture
Contracture in isolated adult rat heart cells. Role of Ca2+, ATP, and compartmentation.
Contracture
Preconditioning in rat hearts is independent of mitochondrial F1F0 ATPase inhibition.
Coronary Disease
Ecto-F1-ATPase/P2Y pathways in metabolic and vascular functions of high density lipoproteins.
Coronary Disease
The potential role of mitochondrial ATP synthase inhibitory factor 1 (IF1) in coronary heart disease: a literature review.
COVID-19
A proposed mechanism for the possible therapeutic potential of Metformin in COVID-19.
COVID-19
The H+-ATPase (V-ATPase): from proton pump to signaling complex in health and disease.
Cutis Laxa
Expanding the clinical and molecular spectrum of ATP6V1A related metabolic cutis laxa.
Cutis Laxa
Impaired glycosylation and cutis laxa caused by mutations in the vesicular H+-ATPase subunit ATP6V0A2.
Cystic Fibrosis
A single-cell atlas of the airway epithelium reveals the CFTR-rich pulmonary ionocyte.
Cystic Fibrosis
Cl- channels regulate lipid droplet formation via Rab8a expression during adipocyte differentiation.
Cystic Fibrosis
Effect of salinity and temperature on the expression of genes involved in branchial ion transport processes in European sea bass.
Cystic Fibrosis
Expression of carbonic anhydrase, cystic fibrosis transmembrane regulator (CFTR) and V-H(+)-ATPase in the lancelet Branchiostoma lanceolatum (Pallas, 1774).
Cystic Fibrosis
Expression of ion transport-associated proteins in human efferent and epididymal ducts.
Cystic Fibrosis
Heat treatment of thioredoxin fusions increases the purity of ?-helical transmembrane protein constructs.
Cystic Fibrosis
Hsp104 facilitates the endoplasmic-reticulum-associated degradation of disease-associated and aggregation-prone substrates.
Cystic Fibrosis
Pseudomonas aeruginosa pyocyanin inactivates lung epithelial vacuolar ATPase-dependent cystic fibrosis transmembrane conductance regulator expression and localization.
Cystic Fibrosis
Regulated traffic of anion transporters in mammalian Brunner's glands: a role for water and fluid transport.
Cystic Fibrosis
Role of the energy sensor AMP-activated protein kinase in renal physiology and disease.
Cystic Fibrosis
The cellular localization of Na(+)/H(+) exchanger 1, cystic fibrosis transmembrane conductance regulator, potassium channel, epithelial sodium channel ? and vacuolar-type H+-ATPase in human eccrine sweat glands.
Cystic Fibrosis
The IP3 R Binding Protein Released With Inositol 1,4,5-Trisphosphate Is Expressed in Rodent Reproductive Tissue and Spermatozoa.
Cysts
Apparent dominance of the G1-G3 genetic cluster of Echinococcus granulosus strains in the central inland region of Portugal.
Cysts
ATP synthase is required for male fertility and germ cell maturation in Drosophila testes.
Cysts
Kidney intercalated cells and the transcription factor FOXi1 drive cystogenesis in tuberous sclerosis complex.
Cytochrome-c Oxidase Deficiency
Noninvasive diagnostics of mitochondrial disorders in isolated lymphocytes with high resolution respirometry.
Cytomegalovirus Infections
Cellular v-ATPase is required for virion assembly compartment formation in human cytomegalovirus infection.
Deafness
Loss of vacuolar-type H+-ATPase induces caspase-independent necrosis-like death of hair cells in zebrafish neuromasts.
Deafness
Mutations in the gene encoding B1 subunit of H+-ATPase cause renal tubular acidosis with sensorineural deafness.
Deafness
New insights into the pathogenesis of renal tubular acidosis--from functional to molecular studies.
Deafness
The vacuolar-ATPase B1 subunit in distal tubular acidosis: novel mutations and mechanisms for dysfunction.
Dehydration
Comparative effects of allelochemical and water stress in roots of Lycopersicon esculentum Mill. (Solanaceae).
Dehydration
Reproducible improvements in order and diffraction limit of crystals of bovine mitochondrial F(1)-ATPase by controlled dehydration.
Dehydration
The Gene Encoding Subunit A of the Vacuolar H+-ATPase From Cotton Plays an Important Role in Conferring Tolerance to Water Deficit.
Dementia
Abnormal levels of prohibitin and ATP synthase in the substantia nigra and frontal cortex in Parkinson's disease.
Dengue
Novel binding between pre-membrane protein and vacuolar ATPase is required for efficient dengue virus secretion.
Dent Disease
A pure chloride channel mutant of CLC-5 causes Dent's disease via insufficient V-ATPase activation.
Dent Disease
Altered polarity and expression of H+-ATPase without ultrastructural changes in kidneys of Dent's disease patients.
Dent Disease
Comparative ontogeny, processing, and segmental distribution of the renal chloride channel, ClC-5.
Dental Caries
Streptococcus salivarius Isolates of Varying Acid Tolerance Exhibit F1F0-ATPase Conservation.
Dental Caries
[Dynamic changes of aciduric virulence factor membrane-bound proton-translocating ATPase of Streptococcus mutans in the development of dental caries].
Dermatitis, Phototoxic
Modulation of the phototoxic effect of hypericin in human leukemia CEM cell line by N-ethylmaleimide, amiloride and omeprazole.
Dermatomyositis
Pyruvate kinase M2 and the mitochondrial ATPase Inhibitory Factor 1 provide novel biomarkers of dermatomyositis: a metabolic link to oncogenesis.
Diabetes Mellitus
ATP synthase ?-subunit abnormality in pancreas islets of rats with polycystic ovary syndrome and type 2 diabetes mellitus.
Diabetes Mellitus
Identification of ATP Synthase As a Lipid Peroxide Protein Adduct in Pancreatic Islets From Humans With and Without Type 2 Diabetes Mellitus.
Diabetes Mellitus, Experimental
Insulin-status-dependent modulation of FoF1-ATPase activity in rat liver mitochondria.
Diabetes Mellitus, Type 2
ATP synthase ?-subunit abnormality in pancreas islets of rats with polycystic ovary syndrome and type 2 diabetes mellitus.
Diabetes Mellitus, Type 2
Banting Lecture 1995. A lesson in metabolic regulation inspired by the glucokinase glucose sensor paradigm.
Diabetes Mellitus, Type 2
Body and Liver Fat Mass Rather Than Muscle Mitochondrial Function Determines Glucose Metabolism in Women with a History of Gestational Diabetes.
Diabetes Mellitus, Type 2
Decreased insulin-stimulated ATP synthesis and phosphate transport in muscle of insulin-resistant offspring of type 2 diabetic parents.
Diabetes Mellitus, Type 2
Identification of ATP Synthase As a Lipid Peroxide Protein Adduct in Pancreatic Islets From Humans With and Without Type 2 Diabetes Mellitus.
Diabetes Mellitus, Type 2
Proteome analysis reveals phosphorylation of ATP synthase beta -subunit in human skeletal muscle and proteins with potential roles in type 2 diabetes.
Diabetes Mellitus, Type 2
V-ATPase blockade reduces renal gluconeogenesis and improves insulin secretion in type 2 diabetic rats.
Diabetic Cardiomyopathies
Mitochondrial Calpain-1 Disrupts ATP Synthase and Induces Superoxide Generation in Type 1 Diabetic Hearts: A Novel Mechanism Contributing to Diabetic Cardiomyopathy.
Diabetic Cardiomyopathies
Specific amino acid supplementation rescues the heart from lipid overload-induced insulin resistance and contractile dysfunction by targeting the endosomal mTOR-v-ATPase axis.
Diabetic Nephropathies
ATP synthase subunit-? down-regulation aggravates diabetic nephropathy.
Diphtheria
In silico design of fusion toxin DT389GCSF and comparison of interaction it with GCSF receptor rather than DT486GCSF.
Diphtheria
The cytotoxic action of diphtheria toxin and its degradation in intact Vero cells are inhibited by bafilomycin A1, a specific inhibitor of vacuolar-type H(+)-ATPase.
Down Syndrome
Cloning of the cDNA for the human ATP synthase OSCP subunit (ATP5O) by exon trapping and mapping to chromosome 21q22.1-q22.2.
Down Syndrome
Epigallocatechin-3-Gallate Plus Omega-3 Restores the Mitochondrial Complex I and F0F1-ATP Synthase Activities in PBMCs of Young Children with Down Syndrome: A Pilot Study of Safety and Efficacy.
Dysentery, Bacillary
Interfacial amino acids support Spa47 oligomerization and shigella type three secretion system activation.
Dysentery, Bacillary
MxiN Differentially Regulates Monomeric and Oligomeric Species of the Shigella Type Three Secretion System ATPase Spa47.
Dysentery, Bacillary
Shutting Down Shigella Secretion: Characterizing Small Molecule Type Three Secretion System ATPase Inhibitors.
Dysentery, Bacillary
Structural and Biochemical Characterization of Spa47 Provides Mechanistic Insight into Type III Secretion System ATPase Activation and Shigella Virulence Regulation.
Encephalitis, Japanese
Japanese encephalitis virus infection in Vero cells: the involvement of intracellular acidic vesicles in the early phase of viral infection was observed with the treatment of a specific vacuolar type H+-ATPase inhibitor, bafilomycin A1.
Endometriosis
Use of proteomic analysis of endometriosis to identify different protein expression in patients with endometriosis versus normal controls.
Endometriosis
[Application of two dimensional electrophoresis,western blot and mass spectrum to screen markers of endometriosis]
Endotoxemia
Deletion of capn4 Protects the Heart Against Endotoxemic Injury by Preventing ATP Synthase Disruption and Inhibiting Mitochondrial Superoxide Generation.
Epilepsy
ATP Synthase Subunit Beta Immunostaining is Reduced in the Sclerotic Hippocampus of Epilepsy Patients.
Epilepsy
De novo mutations of the ATP6V1A gene cause developmental encephalopathy with epilepsy.
Esophageal Neoplasms
Effects of diphyllin as a novel V-ATPase inhibitor on TE-1 and ECA-109 cells.
Esophageal Neoplasms
Prognostic significance and function of the vacuolar H+-ATPase subunit V1E1 in esophageal squamous cell carcinoma.
Esophageal Neoplasms
Vacuolar H+-ATPase Subunit V0C Regulates Aerobic Glycolysis of Esophageal Cancer Cells via PKM2 Signaling.
Esophageal Squamous Cell Carcinoma
Multi-cancer V-ATPase molecular signatures: A distinctive balance of subunit C isoforms in esophageal carcinoma.
Esophageal Squamous Cell Carcinoma
Prognostic significance and function of the vacuolar H+-ATPase subunit V1E1 in esophageal squamous cell carcinoma.
Fanconi Syndrome
Physiological importance of endosomal acidification: potential role in proximal tubulopathies.
Fatty Liver
Bouchardatine analogue alleviates non-alcoholic hepatic fatty liver disease/non-alcoholic steatohepatitis in high-fat fed mice by inhibiting ATP synthase activity.
Fatty Liver
sMutations in the V-ATPase assembly factor VMA21 cause a congenital disorder of glycosylation with autophagic liver disease.
Feline Infectious Peritonitis
Nanoparticulate vacuolar ATPase blocker exhibits potent host-targeted antiviral activity against feline coronavirus.
Fragile X Syndrome
ATP Synthase c-Subunit Leak Causes Aberrant Cellular Metabolism in Fragile X Syndrome.
Frontotemporal Dementia
C9orf72 and smcr8 mutant mice reveal MTORC1 activation due to impaired lysosomal degradation and exocytosis.
Frontotemporal Dementia
Mitochondrial hyperpolarization in iPSC-derived neurons from patients of FTDP-17 with 10+16 MAPT mutation leads to oxidative stress and neurodegeneration.
Frontotemporal Lobar Degeneration
Rescue of progranulin deficiency associated with frontotemporal lobar degeneration by alkalizing reagents and inhibition of vacuolar ATPase.
Fructose Intolerance
Interaction between aldolase and vacuolar H+-ATPase: evidence for direct coupling of glycolysis to the ATP-hydrolyzing proton pump.
Ganglion Cysts
Altered Mitochondrial ATP Synthase Expression in the Rat Dorsal Root Ganglion After Sciatic Nerve Injury and Analgesic Effects of Intrathecal ATP.
Gastroesophageal Reflux
In Pursuit of the Parietal Cell - An Evolution of Scientific Methodology and Techniques.
Genetic Diseases, Inborn
Mitochondrial ATP synthase subunit c stored in hereditary ceroid-lipofuscinosis contains trimethyl-lysine.
Genetic Diseases, Inborn
V-ATPases and osteoclasts: ambiguous future of V-ATPases inhibitors in osteoporosis.
Genetic Diseases, Inborn
Vacuolar-type proton ATPase as regulator of membrane dynamics in multicellular organisms.
Glioblastoma
Role of endolysosomes and pH in the pathogenesis and treatment of glioblastoma.
Glioblastoma
Up-regulation of cholesterol associated genes as novel resistance mechanism in glioblastoma cells in response to archazolid B.
Glioma
A GBM-like V-ATPase signature directs cell-cell tumor signaling and reprogramming via large oncosomes.
Glioma
Brain lipid-binding protein promotes proliferation and modulates cell cycle in C6 rat glioma cells.
Glioma
Contribution of a H+ pump in determining the resting potential of neuroblastoma cells.
Glioma
Increase in secretion of glial cell line-derived neurotrophic factor from glial cell lines by inhibitors of vacuolar ATPase.
Glioma
Specific V-ATPase expression sub-classifies IDHwt lower-grade gliomas and impacts glioma growth in vivo.
Glomerulonephritis, IGA
Identification of G8969>A in mitochondrial ATP6 gene that severely compromises ATP synthase function in a patient with IgA nephropathy.
Glucose Intolerance
Inheritance of a mitochondrial DNA defect and impaired glucose tolerance in BHE/Cdb rats.
Glucose Intolerance
The effects of repeated exposure to sub-toxic doses of plecomacrolide antibiotics on the endocrine pancreas.
Granular Cell Tumor
Whole-exome sequencing reveals novel vacuolar ATPase genes' variants and variants in genes involved in lysosomal biology and autophagosomal formation in oral granular cell tumors.
h+-transporting two-sector atpase deficiency
A novel homozygous TMEM70 mutation results in congenital cataract and neonatal mitochondrial encephalo-cardiomyopathy.
h+-transporting two-sector atpase deficiency
A plant proton-pumping inorganic pyrophosphatase functionally complements the vacuolar ATPase transport activity and confers bafilomycin resistance in yeast.
h+-transporting two-sector atpase deficiency
Alleviation of neuronal energy deficiency by mTOR inhibition as a treatment for mitochondria-related neurodegeneration.
h+-transporting two-sector atpase deficiency
Anomalies of mitochondrial ATP synthase regulation in four different types of neuronal ceroid lipofuscinosis.
h+-transporting two-sector atpase deficiency
ATP synthase deficiency due to m.8528T>C mutation - a novel cause of severe neonatal hyperammonemia requiring hemodialysis.
h+-transporting two-sector atpase deficiency
ATP synthase deficiency due to TMEM70 mutation leads to ultrastructural mitochondrial degeneration and is amenable to treatment.
h+-transporting two-sector atpase deficiency
ATPAF1 deficiency impairs ATP synthase assembly and mitochondrial respiration.
h+-transporting two-sector atpase deficiency
Biochemical thresholds for pathological presentation of ATP synthase deficiencies.
h+-transporting two-sector atpase deficiency
Development of a human mitochondrial oligonucleotide microarray (h-MitoArray) and gene expression analysis of fibroblast cell lines from 13 patients with isolated F1Fo ATP synthase deficiency.
h+-transporting two-sector atpase deficiency
Expression and processing of the TMEM70 protein.
h+-transporting two-sector atpase deficiency
Hyperammonemic crisis in a child with ATP synthase deficiency caused by mtDNA mutation m.8851T>C.
h+-transporting two-sector atpase deficiency
In vitro transport of F1-ATPase beta-subunit into mitochondria of Zajdela hepatoma and rat liver.
h+-transporting two-sector atpase deficiency
Knockout of Tmem70 alters biogenesis of ATP synthase and leads to embryonal lethality in mice.
h+-transporting two-sector atpase deficiency
Loss of LRPPRC causes ATP synthase deficiency.
h+-transporting two-sector atpase deficiency
Loss of mitochondrial ATP synthase subunit beta (Atp2) alters mitochondrial and chloroplastic function and morphology in Chlamydomonas.
h+-transporting two-sector atpase deficiency
m.8993T>G-Associated Leigh Syndrome with Hypocitrullinemia on Newborn Screening.
h+-transporting two-sector atpase deficiency
Mitochondrial ATP synthase deficiency due to a mutation in the ATP5E gene for the F1 epsilon subunit.
h+-transporting two-sector atpase deficiency
Mitochondrial encephalocardio-myopathy with early neonatal onset due to TMEM70 mutation.
h+-transporting two-sector atpase deficiency
Mitochondrial protein sorting as a therapeutic target for ATP synthase disorders.
h+-transporting two-sector atpase deficiency
Molecular basis for the binding and modulation of V-ATPase by a bacterial effector protein.
h+-transporting two-sector atpase deficiency
Noninvasive diagnostics of mitochondrial disorders in isolated lymphocytes with high resolution respirometry.
h+-transporting two-sector atpase deficiency
Persistent pulmonary arterial hypertension in the newborn (PPHN): a frequent manifestation of TMEM70 defective patients.
h+-transporting two-sector atpase deficiency
The ATP Synthase Deficiency in Human Diseases.
h+-transporting two-sector atpase deficiency
TMEM70 mutations are a common cause of nuclear encoded ATP synthase assembly defect: further delineation of a new syndrome.
h+-transporting two-sector atpase deficiency
TMEM70 mutations cause isolated ATP synthase deficiency and neonatal mitochondrial encephalocardiomyopathy.
h+-transporting two-sector atpase deficiency
TMEM70: a mutational hot spot in nuclear ATP synthase deficiency with a pivotal role in complex V biogenesis.
h+-transporting two-sector atpase deficiency
Two components in pathogenic mechanism of mitochondrial ATPase deficiency: energy deprivation and ROS production.
h+-transporting two-sector atpase deficiency
[Mitochondrial ATP synthase deficiency due to 8993T > G mutation on ATP6 gene].
h+-transporting two-sector atpase deficiency
[Molecular bases of diseases caused by mutations in genes encoding subunits of ATP synthase].
Hearing Loss
Loss of vacuolar-type H+-ATPase induces caspase-independent necrosis-like death of hair cells in zebrafish neuromasts.
Hearing Loss
Mice deficient in H+-ATPase a4 subunit have severe hearing impairment associated with enlarged endolymphatic compartments within the inner ear.
Heart Arrest
Mild hypothermia attenuates post-resuscitation brain injury through a V-ATPase mechanism in a rat model of cardiac arrest.
Heart Diseases
Low levels of ATP synthase and cytochrome c oxidase subunit peptide from hearts of copper-deficient rats are not altered by the administration of dimethyl sulfoxide.
Heart Failure
Altered expression of the adenine nucleotide translocase isoforms and decreased ATP synthase activity in skeletal muscle mitochondria in heart failure.
Heart Failure
Functional and bioenergetic consequences of AT1 antagonist olmesartan medoxomil in hearts with postinfarction LV remodeling.
Heart Failure
Increased calpain-1 in mitochondria induces dilated heart failure in mice: role of mitochondrial superoxide anion.
Heart Failure
Signaling and expression for mitochondrial membrane proteins during left ventricular remodeling and contractile failure after myocardial infarction.
Hepatitis C
SEC14L2, a lipid-binding protein, regulates HCV replication in culture with inter- and intra-genotype variations.
Hepatoblastoma
The proton pump inhibitor inhibits cell growth and induces apoptosis in human hepatoblastoma.
Histoplasmosis
The Histoplasma capsulatum vacuolar ATPase is required for iron homeostasis, intracellular replication in macrophages and virulence in a murine model of histoplasmosis.
Hyperalgesia
Altered Mitochondrial ATP Synthase Expression in the Rat Dorsal Root Ganglion After Sciatic Nerve Injury and Analgesic Effects of Intrathecal ATP.
Hypercholesterolemia
sMutations in the V-ATPase assembly factor VMA21 cause a congenital disorder of glycosylation with autophagic liver disease.
Hyperemia
F0F1 ATP synthase activity is differently modulated by coronary reactive hyperemia before and after ischemic preconditioning in the goat.
Hyperglycemia
Glucose-modulated mitochondria adaptation in tumor cells: a focus on ATP synthase and inhibitor factor 1.
Hyperglycemia
Hepatic overexpression of ATP synthase ? subunit activates PI3K/Akt pathway to ameliorate hyperglycemia of diabetic mice.
Hyperglycemia
Hyperglycemia Decreases the Expression of ATP Synthase ? Subunit and Enolase 2 in Glomerular Epithelial Cells.
Hyperglycemia
Mitochondrial ATP synthase regulates corpus cavernosum smooth muscle cell function in vivo and in vitro.
Hyperhomocysteinemia
[Carnitine chloride reduces the severity of experimental hyperhomocysteinemia and promotes lactate utilization by mitochondrial fraction of the rat epididymis].
Hyperlipidemias
Cholesterol diet-induced hyperlipidemia influences gene expression pattern of rat hearts: a DNA microarray study.
Hypersensitivity
A novel role for the yeast protein kinase Dbf2p in vacuolar H+-ATPase function and sorbic acid stress tolerance.
Hypersensitivity
Phosphite-Mediated Suppression of Anthocyanin Accumulation Regulated by Mitochondrial ATP Synthesis and Sugar in Arabidopsis.
Hypersensitivity
Role of TFP1 in vacuolar acidification, oxidative stress and filamentous development in Candida albicans.
Hypertension
A Common Genetic Variant in the 3'-UTR of Vacuolar H+-ATPase ATP6V0A1 Creates a Micro-RNA Motif to Alter Chromogranin A Processing and Hypertension Risk.
Hypertension
Ectopic ATP synthase in endothelial cells: a novel cardiovascular therapeutic target.
Hypertension
Increased proximal tubule NHE-3 and H+-ATPase activities in spontaneously hypertensive rats.
Hypertension
Intracellular signaling for vasoconstrictor coupling factor 6: novel function of beta-subunit of ATP synthase as receptor.
Hypertension
Mitochondrial ATP synthase regulation in heart: defects in hypertension are restored after treatment with captopril.
Hypertension
NBCe2 (Slc4a5) Is Expressed in the Renal Connecting Tubules and Cortical Collecting Ducts and Mediates Base Extrusion.
Hyperthyroidism
A phosphorus-31 nuclear magnetic resonance study of effects of altered thyroid state on cardiac bioenergetics.
Hyperthyroidism
Thyroid status is a key regulator of both flux and efficiency of oxidative phosphorylation in rat hepatocytes.
Hypokalemia
Systemic lupus erythematosus presenting initially as hydrogen ATPase pump defects of distal renal tubular acidosis.
Hypopigmentation
The zebrafish mutants for the V-ATPase subunits d, ac45, E, H and c and their variable pigment dilution phenotype.
Hypospadias
Mitochondrial encephalocardio-myopathy with early neonatal onset due to TMEM70 mutation.
Hypotension
Alterations in the proton ATPase activity of rat liver mitochondria after hemorrhagic shock.
Hypothyroidism
Hypothyroidism leads to a decreased expression of mitochondrial F0F1-ATP synthase in rat liver.
Hypothyroidism
Thyroid status is a key regulator of both flux and efficiency of oxidative phosphorylation in rat hepatocytes.
Immune System Diseases
Comparative transcriptome analysis of Eriocheir japonica sinensis response to environmental salinity.
Infections
A connection between antimicrobial properties of venom peptides and microbial ATP synthase.
Infections
A hypothetical model of crossing Bombyx mori nucleopolyhedrovirus through its host midgut physical barrier.
Infections
Acquisition of the vacuolar ATPase proton pump and phagosome acidification are essential for escape of Francisella tularensis into the macrophage cytosol.
Infections
Alteration in expression of the rat mitochondrial ATPase 6 gene during Pneumocystis carinii infection.
Infections
Analysis and identification of tyrosine phosphorylated proteins in hemocytes of Litopenaeus vannamei infected with WSSV.
Infections
Antimalarial properties and preventive effects on mitochondrial dysfunction by extract and fractions of Phyllanthus amarus (Schum. and Thonn) in Plasmodium berghei-infected mice.
Infections
ATP synthase in slow- and fast-growing mycobacteria is active in ATP synthesis and blocked in ATP hydrolysis direction.
Infections
ATP synthesis is active on the cell surface of the shrimp Litopenaeus vannamei and is suppressed by WSSV infection.
Infections
Bafilomycin A(1) inhibits rhinovirus infection in human airway epithelium: effects on endosome and ICAM-1.
Infections
Binding and entry of a non-enveloped T=4 insect RNA virus is triggered by alkaline pH.
Infections
Characterization of the oligomycin-sensitivity properties of the F1F0-ATPase in mitochondria from rats infected with the liver fluke Fasciola hepatica.
Infections
Computational modeling of TC0583 as a putative component of the Chlamydia muridarum V-type ATP synthase complex and assessment of its protective capabilities as a vaccine antigen.
Infections
Design, synthesis and biological evaluation of diamino substituted cyclobut-3-ene-1,2-dione derivatives for the treatment of drug-resistant tuberculosis.
Infections
Diarylquinolines are bactericidal for dormant mycobacteria as a result of disturbed ATP homeostasis.
Infections
Discovery of the genes in response to white spot syndrome virus (WSSV) infection in Fenneropenaeus chinensis through cDNA microarray.
Infections
Emergence of mmpT5 Variants during Bedaquiline Treatment of Mycobacterium intracellulare Lung Disease.
Infections
Energetics of heart mitochondria during acute phase of Trypanosoma cruzi infection in rats.
Infections
F1 ATP synthase ? subunit is a putative receptor involved in white spot syndrome virus infection in shrimp by binding with viral envelope proteins VP51B and VP150.
Infections
Fire blight host-pathogen interaction: proteome profiles of Erwinia amylovora infecting apple rootstocks.
Infections
Heart FoF1-ATPase changes during the acute phase of Trypanosoma cruzi infection in rats.
Infections
HIF1A and NFAT5 coordinate Na+-boosted antibacterial defense via enhanced autophagy and autolysosomal targeting.
Infections
Influenza A virus-induced early activation of ERK and PI3K mediates V-ATPase-dependent intracellular pH change required for fusion.
Infections
Inhibition by cellular vacuolar ATPase impairs human papillomavirus uncoating and infection.
Infections
Intestinal Expression of H V-ATPase in the Mosquito Aedes albopictus is Tightly Associated with Gregarine Infection.
Infections
Kinetic Characterization of the Shigella Type Three Secretion System ATPase Spa47 Using ?-32P ATP.
Infections
Molecular and functional characterization of vacuolar-ATPase from the American dog tick Dermacentor variabilis.
Infections
Molecular basis for the binding and modulation of V-ATPase by a bacterial effector protein.
Infections
Mycobacterium tuberculosis Controls Phagosomal Acidification by Targeting CISH-Mediated Signaling.
Infections
Mycobacterium tuberculosis protein tyrosine phosphatase (PtpA) excludes host vacuolar-H+-ATPase to inhibit phagosome acidification.
Infections
Mycoplasma pneumoniae-derived lipopeptides induce acute inflammatory responses in the lungs of mice.
Infections
pH-independent entry and sequential endosomal sorting are major determinants of hepadnaviral infection in primary hepatocytes.
Infections
PIKfyve/Fab1 is required for efficient V-ATPase and hydrolase delivery to phagosomes, phagosomal killing, and restriction of Legionella infection.
Infections
Role of the cytoplasmic domain of the beta-subunit of integrin alpha(v)beta6 in infection by foot-and-mouth disease virus.
Infections
Shedding light on the role of photosynthesis in pathogen colonization and host defense.
Infections
Shutting Down Shigella Secretion: Characterizing Small Molecule Type Three Secretion System ATPase Inhibitors.
Infections
Staphylococcus aureus ATP Synthase Promotes Biofilm Persistence by Influencing Innate Immunity.
Infections
Streptococcus pyogenes transcriptome changes in inflammatory environment of necrotizing fasciitis.
Infections
Studies of the viral binding proteins of shrimp BP53, a receptor of white spot syndrome virus.
Infections
Suppressing dengue-2 infection by chemical inhibition of Aedes aegypti host factors.
Infections
The contribution of Candida albicans vacuolar ATPase subunit V1B encoded by VMA2 to stress response, autophagy, and virulence is independent of environmental pH.
Infections
The early phagosomal stage of Francisella tularensis determines optimal phagosomal escape and Francisella pathogenicity island protein expression.
Infections
The role of F1 ATP synthase beta subunit in WSSV infection in the shrimp, Litopenaeus vannamei.
Infections
TMT-based quantitative proteomic analysis of the effects of Pseudomonas syringae pv. tabaci (Pst) infection on photosynthetic function and the response of the MAPK signaling pathway in tobacco leaves.
Infections
Transcriptional Inhibition of the F1F0-Type ATP Synthase Has Bactericidal Consequences on the Viability of Mycobacteria.
Infections
Variations in gene expression and genomic stability of human hepatoma cells integrated with hepatitis B virus DNA.
Infections
Yersinia pseudotuberculosis blocks the phagosomal acidification of B10.A mouse macrophages through the inhibition of vacuolar H(+)-ATPase activity.
Infections
[Role of proton motive force in the infection of E. coli K-12 cells by bacteriophage T4]
Infertility
ASB-1, a germline-specific isoform of mitochondrial ATP synthase b subunit, is required to maintain the rate of germline development in Caenorhabditis elegans.
Infertility
High-rate spontaneous reversion to cytoplasmic male sterility in sugar beet: a characterization of the mitochondrial genomes.
Infertility, Female
AP1G mediates vacuolar acidification during synergid-controlled pollen tube reception.
Infertility, Male
A fused mitochondrial gene associated with cytoplasmic male sterility is developmentally regulated.
Infertility, Male
ATP synthase is required for male fertility and germ cell maturation in Drosophila testes.
Infertility, Male
Comprehensive transcriptome-based characterization of differentially expressed genes involved in microsporogenesis of radish CMS line and its maintainer.
Infertility, Male
Mitochondrial Cytochrome c Oxidase and F1Fo-ATPase Dysfunction in Peppers (Capsicum annuum L.) with Cytoplasmic Male Sterility and Its Association with orf507 and Ψatp6-2 Genes.
Infertility, Male
Proteome Analysis of the Wild and YX-1 Male Sterile Mutant Anthers of Wolfberry (Lycium barbarum L.).
Infertility, Male
Reduced activity of ATP synthase in mitochondria causes cytoplasmic male sterility in chili pepper.
Infertility, Male
Variations in the structure and transcription of the mitochondrial atp and cox genes in wild Solanum species that induce male sterility in eggplant (S. melongena).
Influenza, Human
18S rRNA is a reliable normalisation gene for real time PCR based on influenza virus infected cells.
Influenza, Human
Antiviral efficacy of nanoparticulate vacuolar ATPase inhibitors against influenza virus infection.
Influenza, Human
Clarithromycin inhibits type a seasonal influenza virus infection in human airway epithelial cells.
Influenza, Human
F1Fo-ATPase, F-type proton-translocating ATPase, at the plasma membrane is critical for efficient influenza virus budding.
Influenza, Human
Inhibitory and combinatorial effect of diphyllin, a v-ATPase blocker, on influenza viruses.
Influenza, Human
Maoto, a Traditional Japanese Herbal Medicine, Inhibits Uncoating of Influenza Virus.
Influenza, Human
The proton translocation domain of cellular vacuolar ATPase provides a target for the treatment of influenza A virus infections.
Insulin Resistance
beta-Carotene accumulation in 3T3-L1 adipocytes inhibits the elevation of reactive oxygen species and the suppression of genes related to insulin sensitivity induced by tumor necrosis factor-alpha.
Insulin Resistance
Correction to: Mitochondrial H+-ATP synthase in human skeletal muscle: contribution to dyslipidaemia and insulin resistance.
Insulin Resistance
Decreased insulin-stimulated ATP synthesis and phosphate transport in muscle of insulin-resistant offspring of type 2 diabetic parents.
Insulin Resistance
Dysfunctional oxidative phosphorylation shunts branched-chain amino acid catabolism onto lipogenesis in skeletal muscle.
Insulin Resistance
Impaired insulin stimulation of muscular ATP production in patients with type 1 diabetes.
Insulin Resistance
Increased lipid availability impairs insulin-stimulated ATP synthesis in human skeletal muscle.
Insulin Resistance
Insulin resistance and the mitochondrial link. Lessons from cultured human myotubes.
Insulin Resistance
Lower fasting muscle mitochondrial activity relates to hepatic steatosis in humans.
Insulin Resistance
Palmitate-Induced Vacuolar-Type H(+)-ATPase Inhibition Feeds Forward into Insulin Resistance and Contractile Dysfunction.
Insulin Resistance
Protocols and pitfalls in obtaining fatty acid-binding proteins for biophysical studies of ligand-protein and protein-protein interactions.
Insulin Resistance
Short-term exercise training does not stimulate skeletal muscle ATP synthesis in relatives of humans with type 2 diabetes.
Insulin Resistance
Specific amino acid supplementation rescues the heart from lipid overload-induced insulin resistance and contractile dysfunction by targeting the endosomal mTOR-v-ATPase axis.
Insulinoma
Differential expression of vacuolar-type H+-ATPase between normal human pancreatic islet B-cells and insulinoma cells.
Insulinoma
Fatty acids and glucose in high concentration down-regulates ATP synthase beta-subunit protein expression in INS-1 cells.
Insulinoma
Insulinoma with hyperproinsulinemia during hypoglycemia and loss of expression of vacuolar-type H(+)-ATPase (V-ATPase) in the tumor tissue.
Insulinoma
Mitochondrial ATP synthase--a possible target protein in the regulation of energy metabolism in vitro and in vivo.
Intellectual Disability
Defective mitochondrial ATPase due to rare mtDNA m.8969G>A mutation-causing lactic acidosis, intellectual disability, and poor growth.
Kearns-Sayre Syndrome
Heterogeneous clinical presentation of the mtDNA NARP/T8993G mutation.
Kidney Calculi
The Vacuolar H+-ATPase B1 Subunit Polymorphism p.E161K Associates with Impaired Urinary Acidification in Recurrent Stone Formers.
Leigh Disease
A mitochondrial ATPase 6 mutation is associated with Leigh syndrome in a family and affects proton flow and adenosine triphosphate output when modeled in Escherichia coli.
Leigh Disease
A novel mitochondrial mutation m.8989G>C associated with neuropathy, ataxia, retinitis pigmentosa - the NARP syndrome.
Leigh Disease
A previously undescribed leukodystrophy in Leigh syndrome associated with T9176C mutation of the mitochondrial ATPase 6 gene.
Leigh Disease
A T-->C mutation at nt 8993 of mitochondrial DNA in a child with Leigh syndrome.
Leigh Disease
Alleviation of neuronal energy deficiency by mTOR inhibition as a treatment for mitochondria-related neurodegeneration.
Leigh Disease
ATP6 homoplasmic mutations inhibit and destabilize the human F1F0-ATP synthase without preventing enzyme assembly and oligomerization.
Leigh Disease
Cytoplasmic transfer of the mtDNA nt 8993 T-->G (ATP6) point mutation associated with Leigh syndrome into mtDNA-less cells demonstrates cosegregation with a decrease in state III respiration and ADP/O ratio.
Leigh Disease
De novo mutation in the mitochondrial ATP synthase subunit 6 gene (T8993G) with rapid segregation resulting in Leigh syndrome in the offspring.
Leigh Disease
Defining the impact on yeast ATP synthase of two pathogenic human mitochondrial DNA mutations, T9185C and T9191C.
Leigh Disease
Fulminant Leigh syndrome and sudden unexpected death in a family with the T9176C mutation of the mitochondrial ATPase 6 gene.
Leigh Disease
Human NARP mitochondrial mutation metabolism corrected with alpha-ketoglutarate/aspartate: a potential new therapy.
Leigh Disease
Humanin expression in skeletal muscles of patients with chronic progressive external ophthalmoplegia.
Leigh Disease
Inefficient coupling between proton transport and ATP synthesis may be the pathogenic mechanism for NARP and Leigh syndrome resulting from the T8993G mutation in mtDNA.
Leigh Disease
Introducing the human Leigh syndrome mutation T9176G into Saccharomyces cerevisiae mitochondrial DNA leads to severe defects in the incorporation of Atp6p into the ATP synthase and in the mitochondrial morphology.
Leigh Disease
Late-onset Leigh syndrome with m.9176T>C mutation in the mitochondrial ATPase 6 gene.
Leigh Disease
Modeling the Leigh syndrome nt8993 T-->C mutation in Escherichia coli F1F0 ATP synthase.
Leigh Disease
Phenotype-genotype correlations in Leigh syndrome: new insights from a multicentre study of 96 patients.
Leigh Disease
Two new mutations in the MT-TW gene leading to the disruption of the secondary structure of the tRNA(Trp) in patients with Leigh syndrome.
Leishmaniasis
Mitochondria and lipid raft-located FOF1-ATP synthase as major therapeutic targets in the antileishmanial and anticancer activities of ether lipid edelfosine.
Leishmaniasis, Visceral
Cloning and characterization of a V-ATPase subunit C from the American visceral leishmaniasis vector Lutzomyia longipalpis modulated during development and blood ingestion.
Leukemia
Conditional Deletion of the V-ATPase a2-Subunit Disrupts Intrathymic T Cell Development.
Leukemia
Ectopic ATP synthase ? subunit proteins on human leukemia cell surface interact with platelets by binding glycoprotein IIb.
Leukemia
Pharmacologic inhibition of vacuolar H+ ATPase reduces physiologic and oncogenic Notch signaling.
Leukemia
Understanding and exploiting the mechanistic basis for selectivity of polyketide inhibitors of F(0)F(1)-ATPase.
Leukemia
V-ATPase upregulation during early pregnancy: a possible link to establishment of an inflammatory response during preimplantation period of pregnancy.
Leukemia, Erythroblastic, Acute
Severe energy impairment consequent to inactivation of mitochondrial ATP synthase as an early event in cell death: a mechanism for the selective sensitivity to H2O2 of differentiating erythroleukemia cells.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Down-regulation of mitochondrial ATPase by hypermethylation mechanism in chronic myeloid leukemia is associated with multidrug resistance.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Hypermethylation of CpG sites at the promoter region is associated with deregulation of mitochondrial ATPsyn-? and chemoresistance in acute myeloid leukemia.
Leukemia, Myeloid, Acute
Deregulation of mitochondrial ATPsyn-? in acute myeloid leukemia cells and with increased drug resistance.
Leukemia, Myeloid, Acute
Inhibition of the ecto-beta subunit of F1F0-ATPase inhibits proliferation and induces apoptosis in acute myeloid leukemia cell lines.
Leukemia, Myeloid, Acute
Vacuolar ATPase as a possible therapeutic target in human acute myeloid leukemia.
Liver Cirrhosis, Biliary
Analysis of the clinical relevance of antimitochondrial antibodies to the ?- and ?-subunits of the F1F0-ATPase in patients with primary biliary cirrhosis.
Liver Cirrhosis, Biliary
Antimitochondrial antibodies (AMA) in primary biliary cirrhosis. I. Separation of the PBC antigen activity from mitochondrial ATPase activity.
Liver Cirrhosis, Biliary
Mitochondrial antibodies in primary biliary cirrhosis. VI. Association of the complement fixing antigen with a component of the mitochondrial F1-ATPase complex.
Liver Cirrhosis, Biliary
The association of the autoantigens of primary biliary cirrhosis with the mitochondrial H+-ATPase--a reassessment.
Liver Cirrhosis, Biliary
The in vitro production of antibodies to mitochondrial antigens by peripheral blood mononuclear cells from patients with primary biliary cirrhosis.
Liver Cirrhosis, Biliary
The M2 autoantigens of primary biliary cirrhosis are not subunits of the mitochondrial H+-ATPase.
Liver Cirrhosis, Biliary
Use of immunoblotting to characterize the mitochondrial antigens recognized by anti-mitochondrial autoantibodies.
Liver Diseases
MED1 mediator subunit is a key regulator of hepatic autophagy and lipid metabolism.
Liver Diseases
One Ring to Rule Them All: Mitochondrial Circular RNAs Control Mitochondrial Function.
Liver Diseases
sMutations in the V-ATPase assembly factor VMA21 cause a congenital disorder of glycosylation with autophagic liver disease.
Liver Diseases
[Detection of antibodies to submitochondrial particles, F1-ATPase complex and liver specific lipoprotein in liver diseases using ELISA]
Liver Neoplasms
Oxidative phosphorylation activation is an important characteristic of DOX resistance in hepatocellular carcinoma cells.
Liver Neoplasms
The AKT-independent MET-V-ATPase-MTOR axis suppresses liver cancer vaccination.
Liver Neoplasms, Experimental
Isolation and comparative studies of mitochondrial F1-ATPase from Morris hepatoma and rat liver.
Liver Neoplasms, Experimental
Kinetic properties of mitochondrial H+-adenosine triphosphatase in Morris hepatoma 3924A.
Lung Diseases
Decrease in cytosolic ATP/ADP ratio and activation of pyruvate kinase after in vitro addition of almitrine in hepatocytes isolated from fasted rats.
Lung Injury
Serial analysis of gene expression in mice with lipopolysaccharide-induced acute lung injury.
Lung Neoplasms
Ectopic ATP Synthase Blockade Suppresses Lung Adenocarcinoma Growth by Activating the Unfolded Protein Response.
Lung Neoplasms
Identification of ATP synthase beta subunit (ATPB) on the cell surface as a non-small cell lung cancer (NSCLC) associated antigen.
Lung Neoplasms
New High-throughput Screen Identifies Compounds That Reduce Viability Specifically In Liver Cancer Cells That Express High Levels of SALL4 by Inhibiting Oxidative Phosphorylation.
Lung Neoplasms
Precise Cancer Anti-acid Therapy Monitoring Using pH-Sensitive MnO2@BSA Nanoparticles by Magnetic Resonance Imaging.
Lung Neoplasms
Quantitative proteomic analysis of human lung tumor xenografts treated with the ectopic ATP synthase inhibitor citreoviridin.
Lung Neoplasms
Selective ATP hydrolysis inhibition in F1Fo ATP synthase enhances radiosensitivity in non-small-cell lung cancer cells (A549).
Lung Neoplasms
Silencing of secretory clusterin sensitizes NSCLC cells to V-ATPase inhibitors by downregulating survivin.
Lung Neoplasms
Suppressed translation and ULK1 degradation as potential mechanisms of autophagy limitation under prolonged starvation.
Lung Neoplasms
Temporal Phosphoproteome Dynamics Induced by an ATP Synthase Inhibitor Citreoviridin.
Lung Neoplasms
The expression of V-ATPase is associated with drug resistance and pathology of non-small-cell lung cancer.
Lung Neoplasms
[The expression of ABCG4, V-ATPase and clinic significance of their correlation with NSCLC.]
Lupus Erythematosus, Systemic
Selection of a gene for apolipoprotein A1 using autoantibodies from a patient with systemic lupus erythematosus.
Lupus Erythematosus, Systemic
Systemic lupus erythematosus presenting initially as hydrogen ATPase pump defects of distal renal tubular acidosis.
Lymphatic Metastasis
Silencing of LASS2/TMSG1 enhances invasion and metastasis capacity of prostate cancer cell.
Lymphoma
Cyclic AMP-dependent phosphorylation of the precursor to beta subunit of mitochondrial F1-ATPase: a physiological mistake?
Lymphoma
Differences in T-cell-receptor gene rearrangement and transcription in nasal lymphomas of natural killer and T-cell types: implications on cellular origin.
Lymphoma
Identification of V-ATPase as a molecular sensor of SOX11-levels and potential therapeutic target for mantle cell lymphoma.
Lymphoma, B-Cell
Identification of collaborative activities with oxidative phosphorylation in bipolar disorder.
Lymphoma, B-Cell
Regulation of Bcl-xL-ATP Synthase Interaction by Mitochondrial Cyclin B1-Cyclin-Dependent Kinase-1 Determines Neuronal Survival.
Lymphoma, Follicular
Follicular lymphoma-associated mutations in vacuolar ATPase ATP6V1B2 activate autophagic flux and MTOR.
Lymphoma, Mantle-Cell
Identification of V-ATPase as a molecular sensor of SOX11-levels and potential therapeutic target for mantle cell lymphoma.
Lysosomal Storage Diseases
Batten disease fibroblasts in culture accumulate mitochondrial ATP synthase subunit 9.
Lysosomal Storage Diseases
Misrouting of v-ATPase subunit V0a1 dysregulates lysosomal acidification in a neurodegenerative lysosomal storage disease model.
Malaria
A malaria parasite-encoded vacuolar H(+)-ATPase is targeted to the host erythrocyte.
Malaria
Acidification of the malaria parasite's digestive vacuole by a H+-ATPase and a H+-pyrophosphatase.
Malaria
Antimalarial properties and preventive effects on mitochondrial dysfunction by extract and fractions of Phyllanthus amarus (Schum. and Thonn) in Plasmodium berghei-infected mice.
Malaria
ATP synthase complex of Plasmodium falciparum: dimeric assembly in mitochondrial membranes and resistance to genetic disruption.
Malaria
Membrane potential of erythrocytic stages of Plasmodium chabaudi free of the host cell membrane.
Malaria
Mitochondrial ATP synthase is dispensable in blood-stage Plasmodium berghei rodent malaria but essential in the mosquito phase.
Malaria
Proteolipid of vacuolar H(+)-ATPase of Plasmodium falciparum: cDNA cloning, gene organization and complementation of a yeast null mutant.
Malaria
Selective toxicity of the antimalarial primaquine-evidence for both uncoupling and inhibitory effects of a metabolite on the energetics of mitochondria and its ATP synthase complex.
Malaria
Vacuolar H(+)-ATPase localized in plasma membranes of malaria parasite cells, Plasmodium falciparum, is involved in regional acidification of parasitized erythrocytes.
Malnutrition
Effect of prolonged undernutrition on rat diaphragm mitochondrial respiration.
Medullary Sponge Kidney
Medullary sponge kidney associated with primary distal renal tubular acidosis and mutations of the H+-ATPase genes.
Melanoma
Abnormal acidification of melanoma cells induces tyrosinase retention in the early secretory pathway.
Melanoma
Cell surface F1/FO ATP synthase contributes to interstitial flow-mediated development of the acidic microenvironment in tumor tissues.
Melanoma
Identification of the F1F0 mitochondrial ATPase as a target for modulating skin pigmentation by screening a tagged triazine library in zebrafish.
Melanoma
Immunity to the vacuolar ATPase complex accessory unit ATP6S1 in patients with malignant melanoma.
Melanoma
Induction of ATP synthase ß by H2O2 induces melanogenesis by activating PAH and cAMP/CREB/MITF signaling in melanoma cells.
Melanoma
Myrtenal-induced V-ATPase inhibition - A toxicity mechanism behind tumor cell death and suppressed migration and invasion in melanoma.
Melanoma
Proteomic analysis and the antimetastatic effect of N-(4-methyl)phenyl-O-(4-methoxy) phenyl-thionocarbamate-induced apoptosis in human melanoma SK-MEL-28 cells.
Melanoma
Selective growth inhibition by suppression of F1Fo ATPase in canine malignant melanoma cell lines.
Melanoma
T cell immune regulator 1 is a prognostic marker associated with immune infiltration in glioblastoma multiforme.
Melanoma
The a3 Isoform Vacuolar Type H+-ATPase Promotes Distant Metastasis in the Mouse B16 Melanoma Cells.
Melanoma
Tumor cell cholesterol depletion and V-ATPase inhibition as an inhibitory mechanism to prevent cell migration and invasiveness in melanoma.
Melanoma
Upregulation of V-ATPase by STAT3 Activation Promotes Anoikis Resistance and Tumor Metastasis.
Melanoma, Amelanotic
Differences in cytochrome oxidase and mitochondrial ATPase in melanotic and amelanotic melanoma.
Melanoma, Experimental
The a3 Isoform Vacuolar Type H+-ATPase Promotes Distant Metastasis in the Mouse B16 Melanoma Cells.
MELAS Syndrome
Quantification of OXPHOS gene transcripts during muscle cell differentiation in patients with mitochondrial myopathies.
Mesothelioma
BAMLET kills chemotherapy-resistant mesothelioma cells, holding oleic acid in an activated cytotoxic state.
Metabolic Syndrome
Abnormal lipid metabolism down-regulates adenosine triphosphate synthase ?-subunit protein expression in corpus cavernosum smooth muscle in vitro and in vivo.
Metabolic Syndrome
Slow-Twitch Fiber Proportion in Skeletal Muscle Correlates with Insulin Responsiveness.
Metabolic Syndrome
Xenobiotics that affect oxidative phosphorylation alter differentiation of human adipose-derived stem cells at concentrations that are found in human blood.
Metabolism, Inborn Errors
Nongenomic stimulation of vacuolar H+-ATPases in intercalated renal tubule cells by aldosterone.
Mitochondrial Diseases
A yeast model of the neurogenic ataxia retinitis pigmentosa (NARP) T8993G mutation in the mitochondrial ATP synthase-6 gene.
Mitochondrial Diseases
A yeast-based assay identifies drugs active against human mitochondrial disorders.
Mitochondrial Diseases
Antipeptide antibodies to the carboxy terminal and the DCCD binding region of the human mitochondrial ATP synthase beta-subunit.
Mitochondrial Diseases
Assembly of mitochondrial ATP synthase in cultured human cells: implications for mitochondrial diseases.
Mitochondrial Diseases
ATP6 homoplasmic mutations inhibit and destabilize the human F1F0-ATP synthase without preventing enzyme assembly and oligomerization.
Mitochondrial Diseases
Biochemical thresholds for pathological presentation of ATP synthase deficiencies.
Mitochondrial Diseases
Characterization of Drosophila ATPsynC mutants as a new model of mitochondrial ATP synthase disorders.
Mitochondrial Diseases
Functional assays in high-resolution clear native gels to quantify mitochondrial complexes in human biopsies and cell lines.
Mitochondrial Diseases
Genetic dysfunction of MT-ATP6 causes axonal Charcot-Marie-Tooth disease.
Mitochondrial Diseases
Human Mitochondrial Pathologies of the Respiratory Chain and ATP Synthase: Contributions from Studies of Saccharomyces cerevisiae.
Mitochondrial Diseases
Infantile mitochondrial disorder associated with subclinical hypothyroidism is caused by a rare mitochondrial DNA 8691A>G mutation: a case report.
Mitochondrial Diseases
Knockout of Tmem70 alters biogenesis of ATP synthase and leads to embryonal lethality in mice.
Mitochondrial Diseases
Mitochondrial ATP synthase deficiency due to a mutation in the ATP5E gene for the F1 epsilon subunit.
Mitochondrial Diseases
Mitochondrial disease associated with the T8993G mutation of the mitochondrial ATPase 6 gene: a clinical, biochemical, and molecular study in six families.
Mitochondrial Diseases
Mitochondrial encephalocardio-myopathy with early neonatal onset due to TMEM70 mutation.
Mitochondrial Diseases
Mitochondrial protein sorting as a therapeutic target for ATP synthase disorders.
Mitochondrial Diseases
Mitochonic Acid 5 (MA-5) Facilitates ATP Synthase Oligomerization and Cell Survival in Various Mitochondrial Diseases.
Mitochondrial Diseases
The aleu207-->arg mutation in F1F0-ATP synthase from Escherichia coli. A model for human mitochondrial disease.
Mitochondrial Diseases
The Mitochondrial Permeability Transition in Mitochondrial Disorders.
Mitochondrial Diseases
Two components in pathogenic mechanism of mitochondrial ATPase deficiency: energy deprivation and ROS production.
Mitochondrial Encephalomyopathies
Development and characterization of polyspecific anti-mitochondrion antibodies for proteomics studies on in toto tissue homogenates.
Mitochondrial Encephalomyopathies
Diminished synthesis of subunit a (ATP6) and altered function of ATP synthase and cytochrome c oxidase due to the mtDNA 2 bp microdeletion of TA at positions 9205 and 9206.
Mitochondrial Encephalomyopathies
Positive contribution of pathogenic mutations in the mitochondrial genome to the promotion of cancer by prevention from apoptosis.
Mitochondrial Myopathies
Different laboratory and muscle biopsy findings in a family with an m.8851T>C mutation in the mitochondrial MTATP6 gene.
Mitochondrial Myopathies
Focal deficiency of cytochrome c oxidase and of mitochondrial ATPase with histochemical evidence of loosely coupled oxidative phosphorylation in a mitochondrial myopathy of a patient with bilateral ptosis. An enzyme histochemical, immunocytochemical and fine structural study.
Mitochondrial Myopathies
Mitochondrial myopathy with diffuse activation and focal deficiency of mitochondrial ATPase and carnitine deficiency.
Mucopolysaccharidoses
Increased expression of subunit c of mitochondrial ATP synthase in brain tissue from neuronal ceroid lipofuscinoses and mucopolysaccharidosis cases but not in long-term fibroblast cultures.
Mucopolysaccharidosis I
P-Tau and Subunit c Mitochondrial ATP Synthase Accumulation in the Central Nervous System of a Woman with Hurler-Scheie Syndrome Treated with Enzyme Replacement Therapy for 12 Years.
Multiple Myeloma
Bone Pain Induced by Multiple Myeloma Is Reduced by Targeting V-ATPase and ASIC3.
Multiple Sclerosis, Relapsing-Remitting
Effect of fish and olive oil on mitochondrial ATPase activity and membrane fluidity in patients with relapsing-remitting multiple sclerosis treated with interferon beta 1-b.
Muscle Hypotonia
A previously undescribed leukodystrophy in Leigh syndrome associated with T9176C mutation of the mitochondrial ATPase 6 gene.
Muscle Hypotonia
Common and Novel TMEM70 Mutations in a Cohort of Italian Patients with Mitochondrial Encephalocardiomyopathy.
Muscle Hypotonia
Expanding the clinical and molecular spectrum of ATP6V1A related metabolic cutis laxa.
Muscle Hypotonia
Mitochondrial encephalocardio-myopathy with early neonatal onset due to TMEM70 mutation.
Muscle Hypotonia
Persistent pulmonary arterial hypertension in the newborn (PPHN): a frequent manifestation of TMEM70 defective patients.
Muscle Weakness
Antioxidant defence systems and generation of reactive oxygen species in osteosarcoma cells with defective mitochondria: Effect of selenium.
Muscle Weakness
Correlation between the clinical symptoms and the proportion of mitochondrial DNA carrying the 8993 point mutation in the NARP syndrome.
Muscle Weakness
Defective mitochondrial ATPase due to rare mtDNA m.8969G>A mutation-causing lactic acidosis, intellectual disability, and poor growth.
Muscle Weakness
Impaired ATP synthase assembly associated with a mutation in the human ATP synthase subunit 6 gene.
Muscle Weakness
Mitochondrial ATP synthase inhibition and nitric oxide are involved in muscle weakness that occurs in acute exposure of rats to monocrotophos.
Muscle Weakness
NARP syndrome in a patient harbouring an insertion in the MT-ATP6 gene that results in a truncated protein.
Muscular Atrophy
[Effects of Ligustrazine and Radix Astragali on activities of myosin adenosine triphosphatase of soleus muscle and muscle atrophy in tail-suspended rats]
Muscular Diseases
Activation of mitochondrial ATPase as evidence of loosely coupled oxidative phosphorylation in various skeletal muscle disorders. A histochemical fine-structural study.
Muscular Diseases
Acute Sarcomeric M-Line Disease Associated With ATP Synthase Subunit ? Autoantibodies in Ankylosing Spondylitis.
Muscular Diseases
Marked decrease of mitochondrial DNA with multiple deletions in a patient with familial mitochondrial myopathy.
Muscular Diseases
Retraction notice to: VMA21 Deficiency causes an autophagic myopathy by compromising V-ATPase activity and lysosomal acidification.
Muscular Diseases
VMA21 deficiency causes an autophagic myopathy by compromising V-ATPase activity and lysosomal acidification.
Muscular Diseases
VMA21 deficiency prevents vacuolar ATPase assembly and causes autophagic vacuolar myopathy.
Myocardial Infarction
Fo ATP synthase C subunit serum levels in patients with ST-segment Elevation Myocardial Infarction: Preliminary findings.
Myocardial Infarction
Valsartan reverses post-translational modifications of the delta-subunit of ATP synthase during in vivo canine reperfused myocardial infarction.
Myocardial Ischemia
ATPase activity, IF1 content, and proton conductivity of ESMP from control and ischemic slow and fast heart-rate hearts.
Myocardial Ischemia
Benzodiazepine-based selective inhibitors of mitochondrial F1F0 ATP hydrolase.
Myocardial Ischemia
Effect of reversible ischemia on the activity of the mitochondrial ATPase: relationship to ischemic preconditioning.
Myocardial Ischemia
Effects of oligomycin and acidosis on rates of ATP depletion in ischemic heart muscle.
Myocardial Ischemia
IF1 function in situ in uncoupler-challenged ischemic rabbit, rat, and pigeon hearts.
Myocardial Ischemia
Pharmacological profile of the selective mitochondrial F1F0 ATP hydrolase inhibitor BMS-199264 in myocardial ischemia.
Myocardial Ischemia
Regulation of mitochondrial matrix pH and adenosine 5'-triphosphatase activity during ischemia in slow heart-rate hearts. Role of Pi/H+ symport.
Myocardial Ischemia
Reperfusion after brief repetitive ischemia in porcine myocardium does not alter expression of creatine kinase MM or mitochondrial ATPase mRNAs.
nadh:ubiquinone reductase (h+-translocating) deficiency
Phenotype-genotype correlations in Leigh syndrome: new insights from a multicentre study of 96 patients.
Neoplasm Metastasis
A humanized chimeric antibody Hai178 targeted to the ? subunit of F1F0 ATP synthase.
Neoplasm Metastasis
A novel tumor metastasis suppressor gene LASS2/TMSG1 interacts with vacuolar ATPase through its homeodomain.
Neoplasm Metastasis
An independent endocytic pathway stimulates different monocyte subsets by the a2 N-terminus domain of vacuolar-ATPase.
Neoplasm Metastasis
Analysis of metastasis associated signal regulatory network in colorectal cancer.
Neoplasm Metastasis
Antimetastatic effect of a small-molecule vacuolar H+-ATPase inhibitor in in vitro and in vivo preclinical studies.
Neoplasm Metastasis
ATP Synthase Subunit Epsilon Overexpression Promotes Metastasis by Modulating AMPK Signaling to Induce Epithelial-to-Mesenchymal Transition and Is a Poor Prognostic Marker in Colorectal Cancer Patients.
Neoplasm Metastasis
Atp6v1c1 may regulate filament actin arrangement in breast cancer cells.
Neoplasm Metastasis
Bedaquiline, an FDA-approved drug, inhibits mitochondrial ATP production and metastasis in vivo, by targeting the gamma subunit (ATP5F1C) of the ATP synthase.
Neoplasm Metastasis
Ectopic expression of the ATP synthase ? subunit on the membrane of PC-3M cells supports its potential role in prostate cancer metastasis.
Neoplasm Metastasis
Effect of a V-ATPase inhibitor, FR202126, in syngeneic mouse model of experimental bone metastasis.
Neoplasm Metastasis
Effects of diphyllin as a novel V-ATPase inhibitor on TE-1 and ECA-109 cells.
Neoplasm Metastasis
Expression and Transcriptional Regulation of Human ATP6V1A Gene in Gastric Cancers.
Neoplasm Metastasis
Functional expression of V-ATPases in the plasma membrane of glial cells.
Neoplasm Metastasis
Hematopoietic stem cell specific V-ATPase controls breast cancer progression and metastasis via cytotoxic T cells.
Neoplasm Metastasis
Identification of mitochondrial FoF1-ATP synthase involved in liver metastasis of colorectal cancer.
Neoplasm Metastasis
Inhibition of the vacuolar ATPase induces Bnip3-dependent death of cancer cells and a reduction in tumor burden and metastasis.
Neoplasm Metastasis
Integrated Analyses Reveal the Multi-Omics and Prognostic Characteristics of ATP5B in Breast Cancer.
Neoplasm Metastasis
LASS2 inhibits growth and invasion of bladder cancer by regulating ATPase activity.
Neoplasm Metastasis
Mammary epithelium-specific inactivation of V-ATPase reduces stiffness of extracellular matrix and enhances metastasis of breast cancer.
Neoplasm Metastasis
Measurement of ATP6V1C1 expression in brush cytology samples as a diagnostic and prognostic marker in oral squamous cell carcinoma.
Neoplasm Metastasis
Molecular cloning and characterization of a novel V-ATPase associated protein, DVA9.2, from human dendritic cells.
Neoplasm Metastasis
Myrtenal-induced V-ATPase inhibition - A toxicity mechanism behind tumor cell death and suppressed migration and invasion in melanoma.
Neoplasm Metastasis
Osteoclast proton pump regulator Atp6v1c1 enhances breast cancer growth by activating the mTORC1 pathway and bone metastasis by increasing V-ATPase activity.
Neoplasm Metastasis
Regulation of V-ATPase Assembly in Nutrient Sensing and Function of V-ATPases in Breast Cancer Metastasis.
Neoplasm Metastasis
Silencing of a novel tumor metastasis suppressor gene LASS2/TMSG1 promotes invasion of prostate cancer cell in vitro through increase of vacuolar ATPase activity.
Neoplasm Metastasis
Silencing of atp6v1c1 prevents breast cancer growth and bone metastasis.
Neoplasm Metastasis
Silencing of LASS2/TMSG1 enhances invasion and metastasis capacity of prostate cancer cell.
Neoplasm Metastasis
Silencing of TMSG1 enhances metastasis capacity by targeting V-ATPase in breast cancer.
Neoplasm Metastasis
Silencing of vacuolar ATPase c subunit ATP6V0C inhibits the invasion of prostate cancer cells through a LASS2/TMSG1-independent manner.
Neoplasm Metastasis
Skp1 forms multiple protein complexes, including RAVE, a regulator of V-ATPase assembly.
Neoplasm Metastasis
The a3 Isoform Vacuolar Type H+-ATPase Promotes Distant Metastasis in the Mouse B16 Melanoma Cells.
Neoplasm Metastasis
The asialoglycoprotein receptor suppresses the metastasis of hepatocellular carcinoma via LASS2-mediated inhibition of V-ATPase activity.
Neoplasm Metastasis
The growth and metastasis of human hepatocellular carcinoma xenografts are inhibited by small interfering RNA targeting to the subunit ATP6L of proton pump.
Neoplasm Metastasis
The V-ATPase-inhibitor Archazolid abrogates tumor metastasis via inhibition of endocytic activation of the Rho-GTPase Rac1.
Neoplasm Metastasis
Tumor cell cholesterol depletion and V-ATPase inhibition as an inhibitory mechanism to prevent cell migration and invasiveness in melanoma.
Neoplasm Metastasis
Upregulation of V-ATPase by STAT3 Activation Promotes Anoikis Resistance and Tumor Metastasis.
Neoplasm Metastasis
V-ATPase inhibition by archazolid leads to lysosomal dysfunction resulting in impaired cathepsin B activation in vivo.
Neoplasm Metastasis
V-ATPase Inhibition Regulates Anoikis Resistance and Metastasis of Cancer Cells.
Neoplasm Metastasis
Vacuolar ATPase as a potential therapeutic target and mediator of treatment resistance in cancer.
Neoplasm Metastasis
Warburg Effect Is a Cancer Immune Evasion Mechanism Against Macrophage Immunosurveillance.
Neoplasms
?-Catenin-dependent lysosomal targeting of internalized tumor necrosis factor-? suppresses caspase-8 activation in apoptosis-resistant colon cancer cells.
Neoplasms
A Comprehensive Proteomics Analysis of the JC Virus (JCV) Large and Small Tumor Antigen Interacting Proteins: Large T Primarily Targets the Host Protein Complexes with V-ATPase and Ubiquitin Ligase Activities While Small t Mostly Associates with Those Having Phosphatase and Chromatin-Remodeling Functions.
Neoplasms
A dynamic invertible intramolecular charge-transfer fluorescence probe: real-time monitoring of mitochondrial ATPase activity.
Neoplasms
A GBM-like V-ATPase signature directs cell-cell tumor signaling and reprogramming via large oncosomes.
Neoplasms
A humanized chimeric antibody Hai178 targeted to the ? subunit of F1F0 ATP synthase.
Neoplasms
A novel fatty acid-binding protein 5-estrogen-related receptor ? signaling pathway promotes cell growth and energy metabolism in prostate cancer cells.
Neoplasms
A novel ligand in lymphocyte-mediated cytotoxicity: expression of the beta subunit of H+ transporting ATP synthase on the surface of tumor cell lines.
Neoplasms
A novel potent autophagy inhibitor ECDD-S27 targets vacuolar ATPase and inhibits cancer cell survival.
Neoplasms
A novel RNA aptamer identifies plasma membrane ATP synthase beta subunit as an early marker and therapeutic target in aggressive cancer.
Neoplasms
A novel tumor metastasis suppressor gene LASS2/TMSG1 interacts with vacuolar ATPase through its homeodomain.
Neoplasms
A passive function of mitochondrial ATP synthase: target for tumor killer HAMLET.
Neoplasms
ABCG2/V-ATPase was associated with the drug resistance and tumor metastasis of esophageal squamous cancer cells.
Neoplasms
Abnormal acidification of melanoma cells induces tyrosinase retention in the early secretory pathway.
Neoplasms
Acid microenvironment promotes cell survival of human bone sarcoma through the activation of cIAP proteins and NF-?B pathway.
Neoplasms
Acquired Resistance to HER2-Targeted Therapies Creates Vulnerability to ATP Synthase Inhibition.
Neoplasms
Alteration of the bioenergetic phenotype of mitochondria is a hallmark of breast, gastric, lung and oesophageal cancer.
Neoplasms
An independent endocytic pathway stimulates different monocyte subsets by the a2 N-terminus domain of vacuolar-ATPase.
Neoplasms
An Inhibitor of the F1 subunit of ATP synthase (IF1) modulates the activity of angiostatin on the endothelial cell surface.
Neoplasms
Angiostatin is directly cytotoxic to tumor cells at low extracellular pH: a mechanism dependent on cell surface-associated ATP synthase.
Neoplasms
Angiostatin-like activity of a monoclonal antibody to the catalytic subunit of F1F0 ATP synthase.
Neoplasms
Anti-neoplastic action of aspirin against a T cell lymphoma involves alteration in tumor microenvironment and regulation of tumor cell survival.
Neoplasms
Antimetastatic effect of a small-molecule vacuolar H+-ATPase inhibitor in in vitro and in vivo preclinical studies.
Neoplasms
Application of high-performance liquid chromatography-based analysis of DNA fragments to molecular carcinogenesis.
Neoplasms
ATAD3, a vital membrane bound mitochondrial ATPase involved in tumor progression.
Neoplasms
ATP synthase modulation leads to an increase of spare respiratory capacity in HPV associated cancers.
Neoplasms
ATP Synthase Subunit a Supports Permeability Transition in Yeast Lacking Dimerization Subunits and Modulates yPTP Conductance.
Neoplasms
ATP Synthase Subunit Epsilon Overexpression Promotes Metastasis by Modulating AMPK Signaling to Induce Epithelial-to-Mesenchymal Transition and Is a Poor Prognostic Marker in Colorectal Cancer Patients.
Neoplasms
ATP6L promotes metastasis of colorectal cancer by inducing epithelial-mesenchymal transition.
Neoplasms
Bafilomycin A1 inhibits the growth and metastatic potential of the BEL-7402 liver cancer and HO-8910 ovarian cancer cell lines and induces alterations in their microRNA expression.
Neoplasms
Bioflavonoid regulation of ATPase and hexokinase activity in Ehrlich ascites cell mitochondria.
Neoplasms
Biomarkers of phenethyl isothiocyanate-mediated mammary cancer chemoprevention in a clinically relevant mouse model.
Neoplasms
Bovine Milk Lactoferrin Selectively Kills Highly Metastatic Prostate Cancer PC-3 and Osteosarcoma MG-63 Cells In Vitro.
Neoplasms
Breast cancer associated a2 isoform vacuolar ATPase immunomodulates neutrophils: potential role in tumor progression.
Neoplasms
C9orf72 and smcr8 mutant mice reveal MTORC1 activation due to impaired lysosomal degradation and exocytosis.
Neoplasms
Cancer derived peptide of vacuolar ATPase 'a2' isoform promotes neutrophil migration by autocrine secretion of IL-8.
Neoplasms
Cancer-associated V-ATPase induces delayed apoptosis of protumorigenic neutrophils.
Neoplasms
Cell surface F1/FO ATP synthase contributes to interstitial flow-mediated development of the acidic microenvironment in tumor tissues.
Neoplasms
CERS2 suppresses tumor cell invasion and is associated with decreased V-ATPase and MMP-2/MMP-9 activities in breast cancer.
Neoplasms
Characterization of berberine transport into Coptis japonica cells and the involvement of ABC protein.
Neoplasms
Chemoresistance to concanamycin A1 in human oral squamous cell carcinoma is attenuated by an HDAC inhibitor partly via suppression of Bcl-2 expression.
Neoplasms
Cluster of differentiation 147 mediates chemoresistance in breast cancer by affecting vacuolar H+-ATPase expression and activity.
Neoplasms
Combinational therapy targeting the MET-mTOR-ROS loop disrupts mitochondrial autoregulatory machinery of liver cancer.
Neoplasms
Connecting lysosomes and mitochondria - a novel role for lipid metabolism in cancer cell death.
Neoplasms
Coordinate ?-adrenergic inhibition of mitochondrial activity and angiogenesis arrest tumor growth.
Neoplasms
Curcumin induces a fatal energetic impairment in tumor cells in vitro and in vivo by inhibiting ATP-synthase activity.
Neoplasms
Differences in T-cell-receptor gene rearrangement and transcription in nasal lymphomas of natural killer and T-cell types: implications on cellular origin.
Neoplasms
Different sensitivity of Zajdela hepatoma mitochondrial ATPase activity to uncouplers in digitonin-treated cells and isolated mitochondria.
Neoplasms
Differential effects of 2,4-dinitrophenol and valinomycin (+ K+) on uncoupler-stimulated ATPase of human tumor mitochondria.
Neoplasms
Differential protein expression in honeybee (Apis mellifera L.) larvae: underlying caste differentiation.
Neoplasms
Differential regulation of AMP-activated protein kinase in healthy and cancer cells explains why V-ATPase inhibition selectively kills cancer cells.
Neoplasms
Direct targeting of tumor cell F(1)F(0) ATP-synthase by radioiodine angiostatin in vitro and in vivo.
Neoplasms
Discovery of a novel antitumor benzolactone enamide class that selectively inhibits mammalian vacuolar-type (H+)-atpases.
Neoplasms
Distal intestinal gene expression in Atlantic salmon (Salmo salar L.) fed genetically modified maize
Neoplasms
Down-regulation of mitochondrial F1F0-ATP synthase in human colon cancer cells with induced 5-fluorouracil resistance.
Neoplasms
Downregulated ATP6V1B1 expression acidifies the intracellular environment of cancer cells leading to resistance to antibody-dependent cellular cytotoxicity.
Neoplasms
Dual functions of a monoclonal antibody against cell surface F1F0 ATP synthase on both HUVEC and tumor cells.
Neoplasms
Dual Targeting of v-ATPase and mTORC1 Signaling Disarms Multidrug-Resistant Cancers.
Neoplasms
Ectopic ATP Synthase Blockade Suppresses Lung Adenocarcinoma Growth by Activating the Unfolded Protein Response.
Neoplasms
Effect of a V-ATPase inhibitor, FR202126, in syngeneic mouse model of experimental bone metastasis.
Neoplasms
Efficient execution of cell death in non-glycolytic cells requires the generation of ROS controlled by the activity of mitochondrial H+-ATP synthase.
Neoplasms
Elevated expression of the V-ATPase C subunit triggers JNK-dependent cell invasion and overgrowth in a Drosophila epithelium.
Neoplasms
Elevated expression of the V-ATPase D2 subunit triggers increased energy metabolite levels in KrasG12D -driven cancer cells.
Neoplasms
Endothelial cell surface F1-F0 ATP synthase is active in ATP synthesis and is inhibited by angiostatin.
Neoplasms
Evaluating the potential of vacuolar ATPase inhibitors as anticancer agents and multigram synthesis of the potent salicylihalamide analog saliphenylhalamide.
Neoplasms
Expression and functional role of vacuolar H+-ATPase in human hepatocellular carcinoma.
Neoplasms
Expression of 16 kDa proteolipid of vacuolar-type H(+)-ATPase in human pancreatic cancer.
Neoplasms
Extracellular and Luminal pH Regulation by Vacuolar H+-ATPase Isoform Expression and Targeting to the Plasma Membrane and Endosomes.
Neoplasms
F1-adenosine triphosphatase displays properties characteristic of an antigen presentation molecule for Vgamma9Vdelta2 T cells.
Neoplasms
Genetic basis for the increased expression of vacuolar H(+) translocating ATPase genes upon imatinib treatment in human lymphoblastoid cells.
Neoplasms
Glucose metabolism determines resistance of cancer cells to bioenergetic crisis after cytochrome-c release.
Neoplasms
Glucose-modulated mitochondria adaptation in tumor cells: a focus on ATP synthase and inhibitor factor 1.
Neoplasms
Glycolysis inhibitor screening identifies the bis-geranylacylphloroglucinol protonophore moronone from Moronobea coccinea.
Neoplasms
Glycolytic reprogramming of macrophages activated by NOD1 and TLR4 agonists: No association with proinflammatory cytokine production in normoxia.
Neoplasms
Hematopoietic stem cell specific V-ATPase controls breast cancer progression and metastasis via cytotoxic T cells.
Neoplasms
High glucose uptake unexpectedly is accompanied by high levels of the mitochondrial ß-F1-ATPase subunit in head and neck squamous cell carcinoma.
Neoplasms
High glycolytic activity of tumor cells leads to underestimation of electron transport system capacity when mitochondrial ATP synthase is inhibited.
Neoplasms
HRG-1 enhances cancer cell invasive potential and couples glucose metabolism to cytosolic/extracellular pH gradient regulation by the vacuolar-H(+) ATPase.
Neoplasms
Identification of a new chondropsin class of antitumor compound that selectively inhibits V-ATPases.
Neoplasms
Identification of collaborative activities with oxidative phosphorylation in bipolar disorder.
Neoplasms
Identification of Differentially Expressed Genes Involved in the Formation of Multicellular Tumor Spheroids by HT-29 Colon Carcinoma Cells.
Neoplasms
Identification of genes regulated by oleic acid in Jurkat cells by suppressive subtractive hybridization analysis.
Neoplasms
Identification of mitochondrial FoF1-ATP synthase involved in liver metastasis of colorectal cancer.
Neoplasms
Iejimalides A and B inhibit lysosomal vacuolar H+-ATPase (V-ATPase) activity and induce S-phase arrest and apoptosis in MCF-7 cells.
Neoplasms
Immunochemical analysis of the membrane proteins of rat liver and Zajdela hepatoma mitochondria.
Neoplasms
Immunohistochemical localization of C1 subunit of V-ATPase (ATPase C1) in oral squamous cell cancer and normal oral mucosa.
Neoplasms
Immunoproteomics reveals that cancer of the tongue and the gingivobuccal complex exhibit differential autoantibody response.
Neoplasms
Impairment of lysosomal activity as a therapeutic modality targeting cancer stem cells of embryonal rhabdomyosarcoma cell line RD.
Neoplasms
In vitro transport of F1-ATPase beta-subunit into mitochondria of Zajdela hepatoma and rat liver.
Neoplasms
In vivo amelioration of endogenous antitumor autoantibodies via low-dose P4N through the LTA4H/activin A/BAFF pathway.
Neoplasms
Induction of EGF-dependent apoptosis by vacuolar-type H(+)-ATPase inhibitors in A431 cells overexpressing the EGF receptor.
Neoplasms
Inhibition of iron uptake is responsible for differential sensitivity to V-ATPase inhibitors in several cancer cell lines.
Neoplasms
Inhibition of the ecto-beta subunit of F1F0-ATPase inhibits proliferation and induces apoptosis in acute myeloid leukemia cell lines.
Neoplasms
Inhibition of the vacuolar ATPase induces Bnip3-dependent death of cancer cells and a reduction in tumor burden and metastasis.
Neoplasms
Inhibition of tumor angiogenesis by targeting endothelial surface ATP synthase with sangivamycin.
Neoplasms
Inhibition of tumor cell surface ATP synthesis by pigment epithelium-derived factor: implications for antitumor activity.
Neoplasms
Inhibition of V-ATPases and Carbonic Anhydrases as Interference Strategy with Tumor Acidification Processes.
Neoplasms
Inhibition of vacuolar ATPase subunit in tumor cells delays tumor growth by decreasing the essential macrophage population in the tumor microenvironment.
Neoplasms
Inhibitors of F1F0-ATP synthase enzymes for the treatment of tuberculosis and cancer.
Neoplasms
Integrated Analyses Reveal the Multi-Omics and Prognostic Characteristics of ATP5B in Breast Cancer.
Neoplasms
Interplay Between V-ATPase G1 and Small EV-miRNAs Modulates ERK1/2 Activation in GBM Stem Cells and Nonneoplastic Milieu.
Neoplasms
Involvement of cytochrome c and caspases in apoptotic cell death of human submandibular gland ductal cells induced by concanamycin A.
Neoplasms
Keratin subunit expression in human cultured melanocytes and mouse neural crest cells without formation of filamentous structures.
Neoplasms
Lactate inhibits ATP6V0d2 expression in tumor-associated macrophages to promote HIF-2?-mediated tumor progression.
Neoplasms
Lactoferrin selectively triggers apoptosis in highly metastatic breast cancer cells through inhibition of plasmalemmal V-H+-ATPase.
Neoplasms
LASS2 enhances chemosensitivity of breast cancer by counteracting acidic tumor microenvironment through inhibiting activity of V-ATPase proton pump.
Neoplasms
LASS2 inhibits growth and invasion of bladder cancer by regulating ATPase activity.
Neoplasms
Lgl reduces endosomal vesicle acidification and Notch signaling by promoting the interaction between Vap33 and the V-ATPase complex.
Neoplasms
Lipid droplet velocity is a microenvironmental sensor of aggressive tumors regulated by V-ATPase and PEDF.
Neoplasms
Locally and systemically active glucocorticosteroids modify intestinal absorption of lipids in rats.
Neoplasms
Membrane-bound peptides from V-ATPase subunit a do not interact with an indole-type inhibitor.
Neoplasms
Mitochondria and lipid raft-located FOF1-ATP synthase as major therapeutic targets in the antileishmanial and anticancer activities of ether lipid edelfosine.
Neoplasms
Mitochondrial ATP synthase 6 as an endogenous control in the quantitative RT-PCR analysis of clinical cancer samples.
Neoplasms
Mitochondrial ATPase activities of hepatoma BW7756 and ascites tumor cells. Influence of MG2+ ions, free fatty acids, and uncouplers.
Neoplasms
Mitochondrial F1Fo-ATP synthase translocates to cell surface in hepatocytes and has high activity in tumor-like acidic and hypoxic environment.
Neoplasms
Mitochondrial reprogramming via ATP5H loss promotes multimodal cancer therapy resistance.
Neoplasms
Mitochondrial Targeting Involving Cholesterol-Rich Lipid Rafts in the Mechanism of Action of the Antitumor Ether Lipid and Alkylphospholipid Analog Edelfosine.
Neoplasms
Mode of cell death induction by pharmacological vacuolar H+-ATPase (V-ATPase) inhibition.
Neoplasms
Molecular Analysis by Gene Expression of Mitochondrial ATPase Subunits in Papillary Thyroid Cancer: Is ATP5E Transcript a Possible Early Tumor Marker?
Neoplasms
Molecular cloning and characterization of a novel V-ATPase associated protein, DVA9.2, from human dendritic cells.
Neoplasms
Molecular machineries of pH dysregulation in tumor microenvironment: potential targets for cancer therapy.
Neoplasms
Monitoring of dynamic ATP level changes by oligomycin-modulated ATP synthase inhibition in SW480 cancer cells using fluorescent "On-Off" switching DNA aptamer.
Neoplasms
Multi-cancer V-ATPase molecular signatures: A distinctive balance of subunit C isoforms in esophageal carcinoma.
Neoplasms
Multidrug resistance in oral squamous cell carcinoma: The role of vacuolar ATPases.
Neoplasms
Multiomics reveals ectopic ATP synthase blockade induces cancer cell death via a lncRNA-mediated phospho-signaling network.
Neoplasms
Myrtenal-induced V-ATPase inhibition - A toxicity mechanism behind tumor cell death and suppressed migration and invasion in melanoma.
Neoplasms
Nucleotide sequence of a cDNA for the alpha subunit of human mitochondrial ATP synthase.
Neoplasms
Obatoclax kills anaplastic thyroid cancer cells by inducing lysosome neutralization and necrosis.
Neoplasms
On the mechanism of glycolysis stimulation by neutral detergents in 3T3 and Ehrlich ascites tumor cells.
Neoplasms
Osteoclast proton pump regulator Atp6v1c1 enhances breast cancer growth by activating the mTORC1 pathway and bone metastasis by increasing V-ATPase activity.
Neoplasms
Overexpression of Mitochondrial IF1 Prevents Metastatic Disease of Colorectal Cancer by Enhancing Anoikis and Tumor Infiltration of NK Cells.
Neoplasms
Overexpression of the ATPase Inhibitory Factor 1 Favors a Non-metastatic Phenotype in Breast Cancer.
Neoplasms
pH regulators to target the tumor immune microenvironment in human hepatocellular carcinoma.
Neoplasms
Pharmacologic inhibition of vacuolar H+ ATPase reduces physiologic and oncogenic Notch signaling.
Neoplasms
Pharmacological Targeting of Vacuolar H+-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer.
Neoplasms
POLR2F, ATP6V0A1 and PRNP expression in colorectal cancer: new molecules with prognostic significance?
Neoplasms
Potential therapeutic target for malignant paragangliomas: ATP synthase on the surface of paraganglioma cells.
Neoplasms
Prognostic significance and function of the vacuolar H+-ATPase subunit V1E1 in esophageal squamous cell carcinoma.
Neoplasms
Proton pump inhibitor use and risk of breast cancer, prostate cancer, and malignant melanoma: An Icelandic population-based case-control study.
Neoplasms
Proton pump inhibitors can reverse the YAP mediated paclitaxel resistance in epithelial ovarian cancer.
Neoplasms
Proton Pump Inhibitors Display Antitumor Effects in Barrett's Adenocarcinoma Cells.
Neoplasms
Pyruvate kinase M2 and the mitochondrial ATPase Inhibitory Factor 1 provide novel biomarkers of dermatomyositis: a metabolic link to oncogenesis.
Neoplasms
Quantitative proteomic analysis of human lung tumor xenografts treated with the ectopic ATP synthase inhibitor citreoviridin.
Neoplasms
Queuine Micronutrient Deficiency Promotes Warburg Metabolism and Reversal of the Mitochondrial ATP Synthase in Hela Cells.
Neoplasms
Reactivation of Dihydroorotate Dehydrogenase-Driven Pyrimidine Biosynthesis Restores Tumor Growth of Respiration-Deficient Cancer Cells.
Neoplasms
Recent Advances In Developing Novel Anti-Cancer Drugs Targeting Tumor Hypoxic and Acidic Microenvironments.
Neoplasms
Reciprocal Regulation of V-ATPase and Glycolytic Pathway Elements in Health and Disease.
Neoplasms
Regulation of V-ATPase Activity and Organelle pH by Phosphatidylinositol Phosphate Lipids.
Neoplasms
Regulation of V-ATPase assembly and function of V-ATPases in tumor cell invasiveness.
Neoplasms
Renewed interests in carbonic anhydrase IX in relevance to breast cancer treatment.
Neoplasms
Reprogramming Oxidative Phosphorylation in Cancer: A Role for RNA-Binding Proteins.
Neoplasms
Resistance mechanisms of cancer cells to the novel vacuolar H(+)-ATPase inhibitor archazolid B.
Neoplasms
Resveratrol in Cancer: Cellular and Mitochondrial Consequences of Proton Transport Inhibition.
Neoplasms
Resveratrol Specifically Kills Cancer Cells by a Devastating Increase in the Ca2+ Coupling Between the Greatly Tethered Endoplasmic Reticulum and Mitochondria.
Neoplasms
Reviewing ligand-based rational drug design: the search for an ATP synthase inhibitor.
Neoplasms
Role of Pd(II)-chitooligosaccharides-Gboxin analog in oxidative phosphorylation inhibition and energy depletion: Targeting mitochondrial dynamics.
Neoplasms
Selective upregulation of TNF? expression in classically-activated human monocyte-derived macrophages (M1) through pharmacological interference with V-ATPase.
Neoplasms
Silencing of a novel tumor metastasis suppressor gene LASS2/TMSG1 promotes invasion of prostate cancer cell in vitro through increase of vacuolar ATPase activity.
Neoplasms
Silencing of vacuolar ATPase c subunit ATP6V0C inhibits the invasion of prostate cancer cells through a LASS2/TMSG1-independent manner.
Neoplasms
Skp1 forms multiple protein complexes, including RAVE, a regulator of V-ATPase assembly.
Neoplasms
Specific V-ATPase expression sub-classifies IDHwt lower-grade gliomas and impacts glioma growth in vivo.
Neoplasms
Surface vacuolar ATPase in ameloblastoma contributes to tumor invasion of the jaw bone.
Neoplasms
T cell immune regulator 1 is a prognostic marker associated with immune infiltration in glioblastoma multiforme.
Neoplasms
Targeting breast cancer metabolism with a novel inhibitor of mitochondrial ATP synthesis.
Neoplasms
Targeting Reversible Disassembly as a Mechanism of Controlling V-ATPase Activity.
Neoplasms
Targeting V-ATPase in primary human monocytes by archazolid potently represses the classical secretion of cytokines due to accumulation at the endoplasmic reticulum.
Neoplasms
TGF-beta during human colorectal carcinogenesis: the shift from epithelial to mesenchymal signaling.
Neoplasms
The a3 Isoform Vacuolar Type H+-ATPase Promotes Distant Metastasis in the Mouse B16 Melanoma Cells.
Neoplasms
The Binding Site of the V-ATPase Inhibitor Apicularen Is in the Vicinity of Those for Bafilomycin and Archazolid.
Neoplasms
The bioenergetic signature of isogenic colon cancer cells predicts the cell death response to treatment with 3-bromopyruvate, iodoacetate or 5-fluorouracil.
Neoplasms
The expression of V-ATPase is associated with drug resistance and pathology of non-small-cell lung cancer.
Neoplasms
The F(1)F(0) ATP synthase and mitochondrial respiratory chain complexes are present on the plasma membrane of an osteosarcoma cell line: An immunocytochemical study.
Neoplasms
The F1Fo-ATPase inhibitor, IF1, is a critical regulator of energy metabolism in cancer cells.
Neoplasms
The growth and metastasis of human hepatocellular carcinoma xenografts are inhibited by small interfering RNA targeting to the subunit ATP6L of proton pump.
Neoplasms
The heme binding protein HRG-1 is induced by IGF-I and associates with the Vacuolar (H+) -ATPase to control endosomal pH and receptor trafficking.
Neoplasms
The mechanism underlying the effects of the cell surface ATP synthase on the regulation of intracellular acidification during acidosis.
Neoplasms
The milk-derived lactoferrin inhibits V-ATPase activity by targeting its V1 domain.
Neoplasms
The proton pump inhibitor inhibits cell growth and induces apoptosis in human hepatoblastoma.
Neoplasms
The V-ATPase-inhibitor Archazolid abrogates tumor metastasis via inhibition of endocytic activation of the Rho-GTPase Rac1.
Neoplasms
The Vacuolar ATPase a2-subunit regulates Notch signaling in triple-negative breast cancer cells.
Neoplasms
The vacuolar-ATPase modulates matrix metalloproteinase isoforms in human pancreatic cancer.
Neoplasms
The vacuolar-type ATPase inhibitor archazolid increases tumor cell adhesion to endothelial cells by accumulating extracellular collagen.
Neoplasms
Thioesterase PPT1 balances viral resistance and efficient T cell crosspriming in dendritic cells.
Neoplasms
TM9SF4 is a novel V-ATPase-interacting protein that modulates tumor pH alterations associated with drug resistance and invasiveness of colon cancer cells.
Neoplasms
Tumor cell cholesterol depletion and V-ATPase inhibition as an inhibitory mechanism to prevent cell migration and invasiveness in melanoma.
Neoplasms
Tumor recognition following Vgamma9Vdelta2 T cell receptor interactions with a surface F1-ATPase-related structure and apolipoprotein A-I.
Neoplasms
Tumor-associated vacuolar ATPase subunit promotes tumorigenic characteristics in macrophages.
Neoplasms
Two mutations in mitochondrial ATP6 gene of ATP synthase, related to human cancer, affect ROS, calcium homeostasis and mitochondrial permeability transition in yeast.
Neoplasms
Two-dimensional gel electrophoresis of Caenorhabditis elegans homogenates and identification of protein spots by microsequencing.
Neoplasms
Unique uncoupler-stimulation pattern of mitochondrial ATPase activity of tumor cells, brain, and fetal liver.
Neoplasms
Up-regulated expression of the MAT-8 gene in prostate cancer and its siRNA-mediated inhibition of expression induces a decrease in proliferation of human prostate carcinoma cells.
Neoplasms
Up-regulation of the ATPase inhibitory factor 1 (IF1) of the mitochondrial H+-ATP synthase in human tumors mediates the metabolic shift of cancer cells to a Warburg phenotype.
Neoplasms
Upregulation of V-ATPase by STAT3 Activation Promotes Anoikis Resistance and Tumor Metastasis.
Neoplasms
V-ATPase controls tumor growth and autophagy in a Drosophila model of gliomagenesis.
Neoplasms
V-ATPase inhibition by archazolid leads to lysosomal dysfunction resulting in impaired cathepsin B activation in vivo.
Neoplasms
V-ATPase inhibition increases cancer cell stiffness and blocks membrane related Ras signaling - a new option for HCC therapy.
Neoplasms
V-ATPase: a master effector of E2F1-mediated lysosomal trafficking, mTORC1 activation and autophagy.
Neoplasms
Vacuolar ATPase as a potential therapeutic target and mediator of treatment resistance in cancer.
Neoplasms
Vacuolar H(+)-ATPase: functional mechanisms and potential as a target for cancer chemotherapy.
Neoplasms
Vacuolar H+-ATPase inhibitors overcome Bcl-xL-mediated chemoresistance through restoration of a caspase-independent apoptotic pathway.
Neoplasms
Vacuolar H+-ATPase is down-regulated by the angiogenesis-inhibitory pigment epithelium-derived factor in metastatic prostate cancer cells.
Neoplasms
Vacuolar-ATPase Inhibition Blocks Iron Metabolism to Mediate Therapeutic Effects in Breast Cancer.
Neoplasms
Warburg Effect Is a Cancer Immune Evasion Mechanism Against Macrophage Immunosurveillance.
Neoplasms
Whole-exome sequencing reveals novel vacuolar ATPase genes' variants and variants in genes involved in lysosomal biology and autophagosomal formation in oral granular cell tumors.
Neoplasms
Zr-89 Immuno-PET Targeting Ectopic ATP Synthase Enables In-Vivo Imaging of Tumor Angiogenesis.
Neoplasms
ZT-25, a new vacuolar H(+)-ATPase inhibitor, induces apoptosis and protective autophagy through ROS generation in HepG2 cells.
Neoplasms
[ATAD3, a vital membrane-bound mitochondrial ATPase involved in tumor progression].
Neoplasms
[Silencing of vacuolar ATPase c subunit ATP6V0C inhibits invasion of prostate cancer cells].
Neoplasms
[The expression of ABCG4, V-ATPase and clinic significance of their correlation with NSCLC.]
Neoplasms, Squamous Cell
Immunohistochemical localization of C1 subunit of V-ATPase (ATPase C1) in oral squamous cell cancer and normal oral mucosa.
Nervous System Diseases
Cyclophilin D deficiency attenuates mitochondrial F1Fo ATP synthase dysfunction via OSCP in Alzheimer's disease.
Nervous System Diseases
Defining the pathogenesis of human mtDNA mutations using a yeast model: The case of T8851C.
Neuralgia
Altered Mitochondrial ATP Synthase Expression in the Rat Dorsal Root Ganglion After Sciatic Nerve Injury and Analgesic Effects of Intrathecal ATP.
Neuroblastoma
Amyloid precursor protein and amyloid beta-peptide bind to ATP synthase and regulate its activity at the surface of neural cells.
Neuroblastoma
Autoantibodies to the adenosine triphosphate synthase play a pathogenetic role in Alzheimer's disease.
Neuroblastoma
Contribution of a H+ pump in determining the resting potential of neuroblastoma cells.
Neuroblastoma
Dopamine release via the vacuolar ATPase V0 sector c-subunit, confirmed in N18 neuroblastoma cells, results in behavioral recovery in hemiparkinsonian mice.
Neuroblastoma
Impairment of lysosomal activity as a therapeutic modality targeting cancer stem cells of embryonal rhabdomyosarcoma cell line RD.
Neuroblastoma
Vacuolar-type H+-ATPase V1A subunit is a molecular partner of Wolfram syndrome 1 (WFS1) protein, which regulates its expression and stability.
Neurodegenerative Diseases
CLN6 p.I154del Mutation Causing Late Infantile Neuronal Ceroid Lipofuscinosis in a Large Consanguineous Moroccan Family.
Neurodegenerative Diseases
Defining the impact on yeast ATP synthase of two pathogenic human mitochondrial DNA mutations, T9185C and T9191C.
Neurodegenerative Diseases
Disorders of lysosomal acidification-The emerging role of v-ATPase in aging and neurodegenerative disease.
Neurodegenerative Diseases
Isolation and functional analysis of yeast ubiquitin ligase Rsp5 variants that alleviate the toxicity of human ?-synuclein.
Neurodegenerative Diseases
Misrouting of v-ATPase subunit V0a1 dysregulates lysosomal acidification in a neurodegenerative lysosomal storage disease model.
Neurodegenerative Diseases
Roles for H+ /K+ -ATPase and zinc transporter 3 in cAMP-mediated lysosomal acidification in bafilomycin A1-treated astrocytes.
Neurodegenerative Diseases
Splice isoform and pharmacological studies reveal that sterol depletion relocalizes ?-synuclein and enhances its toxicity.
Neurodegenerative Diseases
The emerging roles of vacuolar-type ATPase-dependent Lysosomal acidification in neurodegenerative diseases.
Neurodegenerative Diseases
Yeast reveal a "druggable" Rsp5/Nedd4 network that ameliorates ?-synuclein toxicity in neurons.
Neuronal Ceroid-Lipofuscinoses
A lysosomal proteinase, the late infantile neuronal ceroid lipofuscinosis gene (CLN2) product, is essential for degradation of a hydrophobic protein, the subunit c of ATP synthase.
Neuronal Ceroid-Lipofuscinoses
Abnormal degradative pathway of mitochondrial ATP synthase subunit c in late infantile neuronal ceroid-lipofuscinosis (Batten disease).
Neuronal Ceroid-Lipofuscinoses
Accumulation of mitochondrial ATP synthase subunit c in muscle in a patient with neuronal ceroid lipofuscinosis (late infantile form).
Neuronal Ceroid-Lipofuscinoses
Analysis of CLN3-protein interactions using the yeast two-hybrid system.
Neuronal Ceroid-Lipofuscinoses
Anomalies of mitochondrial ATP synthase regulation in four different types of neuronal ceroid lipofuscinosis.
Neuronal Ceroid-Lipofuscinoses
Batten disease (ceroid-lipofuscinosis): the enigma of subunit c of mitochondrial ATP synthase accumulation.
Neuronal Ceroid-Lipofuscinoses
Batten disease and the ATP synthase subunit c turnover pathway: raising antibodies to subunit c.
Neuronal Ceroid-Lipofuscinoses
Batten disease fibroblasts in culture accumulate mitochondrial ATP synthase subunit 9.
Neuronal Ceroid-Lipofuscinoses
CLN6 p.I154del Mutation Causing Late Infantile Neuronal Ceroid Lipofuscinosis in a Large Consanguineous Moroccan Family.
Neuronal Ceroid-Lipofuscinoses
Defect of proteolysis of mitochondrial ATP synthase subunit C in neuronal ceroid lipofuscinosis.
Neuronal Ceroid-Lipofuscinoses
Delivery of liposome-sequestered hydrophobic proteins to lysosomes of normal and Batten disease cells.
Neuronal Ceroid-Lipofuscinoses
Different patterns of hydrophobic protein storage in different forms of neuronal ceroid lipofuscinosis (NCL, Batten disease).
Neuronal Ceroid-Lipofuscinoses
Distinct early molecular responses to mutations causing vLINCL and JNCL presage ATP synthase subunit C accumulation in cerebellar cells.
Neuronal Ceroid-Lipofuscinoses
Enzyme replacement therapy with recombinant pro-CTSD (cathepsin D) corrects defective proteolysis and autophagy in neuronal ceroid lipofuscinosis.
Neuronal Ceroid-Lipofuscinoses
Familial Kufs' disease presenting as a progressive myoclonic epilepsy.
Neuronal Ceroid-Lipofuscinoses
Follow-up study of subunit c of mitochondrial ATP synthase (SCMAS) in Batten disease and in unrelated lysosomal disorders.
Neuronal Ceroid-Lipofuscinoses
Increased expression of subunit c of mitochondrial ATP synthase in brain tissue from neuronal ceroid lipofuscinoses and mucopolysaccharidosis cases but not in long-term fibroblast cultures.
Neuronal Ceroid-Lipofuscinoses
Increased urine concentration of subunit c of mitochondrial ATP synthase in neuronal ceroid lipofuscinoses patients.
Neuronal Ceroid-Lipofuscinoses
Ion pores made of mitochondrial ATP synthase subunit c in the neuronal plasma membrane and Batten disease.
Neuronal Ceroid-Lipofuscinoses
Late-infantile Batten disease: purification of the subunit c of the mitochondrial ATP synthase from storage material.
Neuronal Ceroid-Lipofuscinoses
Light and electron microscopic studies on subunit c in cultured fibroblasts in late infantile and juvenile Batten disease.
Neuronal Ceroid-Lipofuscinoses
Loss of the chloride channel ClC-7 leads to lysosomal storage disease and neurodegeneration.
Neuronal Ceroid-Lipofuscinoses
Lysine 43 is trimethylated in subunit C from bovine mitochondrial ATP synthase and in storage bodies associated with batten disease.
Neuronal Ceroid-Lipofuscinoses
Lysosomal proteinosis based on decreased degradation of a specific protein, mitochondrial ATP synthase subunit C: Batten disease.
Neuronal Ceroid-Lipofuscinoses
Lysosomal Storage of Subunit c of Mitochondrial ATP Synthase in Brain-Specific Atp13a2-Deficient Mice.
Neuronal Ceroid-Lipofuscinoses
Mitochondrial abnormalities in CLN2 and CLN3 forms of Batten disease.
Neuronal Ceroid-Lipofuscinoses
Molecular basis of lysosomal accumulation of subunit c of mitochondrial ATP synthase in neuronal ceroid-lipofuscinosis.
Neuronal Ceroid-Lipofuscinoses
Motor neuron degeneration of mice is a model of neuronal ceroid lipofuscinosis (Batten's disease).
Neuronal Ceroid-Lipofuscinoses
New insight into lysosomal protein storage disease: delayed catabolism of ATP synthase subunit c in Batten disease.
Neuronal Ceroid-Lipofuscinoses
Palmitate oxidation in muscle mitochondria of patients with the juvenile form of neuronal ceroid-lipofuscinosis.
Neuronal Ceroid-Lipofuscinoses
Polyunsaturated fatty acids reverse the lysosomal storage and accumulation of subunit 9 of mitochondrial F1F0-ATP synthase in cultured lymphoblasts from patients with Batten disease.
Neuronal Ceroid-Lipofuscinoses
Progress in neuropathology of the neuronal ceroid lipofuscinoses.
Neuronal Ceroid-Lipofuscinoses
Rapid detection of subunit c of mitochondrial ATP synthase in urine as a diagnostic screening method for neuronal ceroid-lipofuscinoses.
Neuronal Ceroid-Lipofuscinoses
Role of subunit-9 of mitochondrial ATP synthase in Batten disease.
Neuronal Ceroid-Lipofuscinoses
Specific delay in the degradation of mitochondrial ATP synthase subunit c in late infantile neuronal ceroid lipofuscinosis is derived from cellular proteolytic dysfunction rather than structural alteration of subunit c.
Neuronal Ceroid-Lipofuscinoses
Specific delay of degradation of mitochondrial ATP synthase subunit c in late infantile neuronal ceroid lipofuscinosis (Batten disease).
Neuronal Ceroid-Lipofuscinoses
Specific storage of subunit c of mitochondrial ATP synthase in lysosomes of neuronal ceroid lipofuscinosis (Batten's disease).
Neuronal Ceroid-Lipofuscinoses
Sphingolipid activator proteins (SAPs) in neuronal ceroid lipofuscinoses (NCL).
Neuronal Ceroid-Lipofuscinoses
The relevance of the storage of subunit c of ATP synthase in different forms and models of Batten disease (NCLs).
Neuronal Ceroid-Lipofuscinoses
Tissue and cellular distribution of subunit c of ATP synthase in Batten disease (neuronal ceroid-lipofuscinosis).
Neuronal Ceroid-Lipofuscinoses
Topographic variabilities of immunoreactivity to subunit c of mitochondrial ATP synthase and lectin binding in late infantile neuronal ceroid-lipofuscinosis.
Neuronal Ceroid-Lipofuscinoses
Tripeptidyl peptidase I, the late infantile neuronal ceroid lipofuscinosis gene product, initiates the lysosomal degradation of subunit c of ATP synthase.
Neuronal Ceroid-Lipofuscinoses
Turnover of F1F0-ATP synthase subunit 9 and other proteolipids in normal and Batten disease fibroblasts.
Neuronal Ceroid-Lipofuscinoses
[Batten disease (Neuronal ceroid lipofuscinoses)--accumulation of ATP synthase subunit c caused by the delay of lysosomal degradation]
Non-alcoholic Fatty Liver Disease
Baicalein attenuates impairment of hepatic lysosomal acidification induced by high fat diet via maintaining V-ATPase assembly.
Non-alcoholic Fatty Liver Disease
Inhibition of mTOR improves the impairment of acidification in autophagic vesicles caused by hepatic steatosis.
Non-alcoholic Fatty Liver Disease
MED1 mediator subunit is a key regulator of hepatic autophagy and lipid metabolism.
Non-alcoholic Fatty Liver Disease
NAFLD Phenotype in Patients With V-ATPase Proton Pump Assembly Defects.
Non-alcoholic Fatty Liver Disease
sMutations in the V-ATPase assembly factor VMA21 cause a congenital disorder of glycosylation with autophagic liver disease.
Obesity
A high fat diet increases mitochondrial fatty acid oxidation and uncoupling to decrease efficiency in rat heart.
Obesity
Mitochondrial ATP synthase ?-subunit production rate and ATP synthase specific activity are reduced in skeletal muscle of humans with obesity.
Obesity
Protocols and pitfalls in obtaining fatty acid-binding proteins for biophysical studies of ligand-protein and protein-protein interactions.
Obesity
Xenobiotics that affect oxidative phosphorylation alter differentiation of human adipose-derived stem cells at concentrations that are found in human blood.
Obesity, Maternal
Mitochondrial dysfunction in the fetoplacental unit in gestational diabetes mellitus.
Ocular Hypertension
Effect of Ocular Hypertension on D-?-Aspartic Acid-Containing Proteins in the Retinas of Rats.
Ophthalmoplegia, Chronic Progressive External
Aberrant synthesis of ATP synthase resulting from a novel deletion in mitochondrial DNA in an African patient with progressive external ophthalmoplegia.
Ophthalmoplegia, Chronic Progressive External
Humanin expression in skeletal muscles of patients with chronic progressive external ophthalmoplegia.
Optic Atrophy
Mitochondrial gene expression changes in normal and mitochondrial mutant cells after exposure to ionizing radiation.
Optic Atrophy, Autosomal Dominant
OPA1 and mitochondrial solute carriers in bioenergetic metabolism.
Optic Atrophy, Autosomal Dominant
Proteasome dysfunction induces excessive proteome instability and loss of mitostasis that can be mitigated by enhancing mitochondrial fusion or autophagy.
Optic Atrophy, Autosomal Dominant
The cristae modulator Optic atrophy 1 requires mitochondrial ATP synthase oligomers to safeguard mitochondrial function.
Optic Atrophy, Hereditary, Leber
A mitochondrial mutation at nt 9101 in the ATP synthase 6 gene associated with deficient oxidative phosphorylation in a family with Leber hereditary optic neuroretinopathy.
Optic Atrophy, Hereditary, Leber
A novel mitochondrial mutation m.8989G>C associated with neuropathy, ataxia, retinitis pigmentosa - the NARP syndrome.
Optic Atrophy, Hereditary, Leber
Mutations in subunit 6 of the F1F0-ATP synthase cause two entirely different diseases.
Optic Nerve Diseases
A novel mitochondrial mutation m.8989G>C associated with neuropathy, ataxia, retinitis pigmentosa - the NARP syndrome.
Optic Nerve Diseases
Mutations in subunit 6 of the F1F0-ATP synthase cause two entirely different diseases.
Osteolysis
Effect of a V-ATPase inhibitor, FR202126, in syngeneic mouse model of experimental bone metastasis.
Osteolysis
Prevention of wear particle-induced osteolysis by a novel V-ATPase inhibitor saliphenylhalamide through inhibition of osteoclast bone resorption.
Osteopetrosis
Chloride channel 7 (CLCN7) gene mutations in intermediate autosomal recessive osteopetrosis.
Osteopetrosis
Disruption of the V-ATPase Functionality as a Way to Uncouple Bone Formation and Resorption - a Novel Target for Treatment of Osteoporosis.
Osteopetrosis
Effects of human a3 and a4 mutations that result in osteopetrosis and distal renal tubular acidosis on yeast V-ATPase expression and activity.
Osteopetrosis
Identification and in silico characterization of a novel p.P208PfsX1 mutation in V-ATPase a3 subunit associated with autosomal recessive osteopetrosis in a Pakistani family.
Osteopetrosis
Mutations in the a3 subunit of the vacuolar H(+)-ATPase cause infantile malignant osteopetrosis.
Osteopetrosis
New insights into the pathogenesis of renal tubular acidosis--from functional to molecular studies.
Osteopetrosis
Optic nerve compression and retinal degeneration in Tcirg1 mutant mice lacking the vacuolar-type H-ATPase a3 subunit.
Osteopetrosis
Osteopetrosis Mutation R444L Causes Endoplasmic Reticulum Retention and Misprocessing of Vacuolar H+-ATPase a3 Subunit.
Osteopetrosis
RANKL treatment releases the negative regulation of the poly(ADP-ribose) polymerase-1 on Tcirg1 gene expression during osteoclastogenesis.
Osteopetrosis
The Caenorhabditis elegans unc-32 gene encodes alternative forms of a vacuolar ATPase a subunit.
Osteopetrosis
The R740S mutation in the V-ATPase a3 subunit increases lysosomal pH, impairs NFATc1 translocation and decreases in vitro osteoclastogenesis.
Osteopetrosis
The R740S mutation in the V-ATPase a3 subunit results in osteoclast apoptosis and defective early-stage autophagy.
Osteopetrosis
The V-ATPase a3 subunit mutation R740S is dominant negative and results in osteopetrosis in mice.
Osteopetrosis
V-ATPase a3 isoform mutations identified in osteopetrosis patients abolish its expression and disrupt osteoclast function.
Osteopetrosis
V-ATPases in osteoclasts: structure, function and potential inhibitors of bone resorption.
Osteoporosis
5-(5,6-Dichloro-2-indolyl)-2-methoxy-2,4-pentadienamides: novel and selective inhibitors of the vacuolar H+-ATPase of osteoclasts with bone antiresorptive activity.
Osteoporosis
A rationale for osteoclast selectivity of inhibiting the lysosomal V-ATPase a3 isoform.
Osteoporosis
Disruption of the V-ATPase Functionality as a Way to Uncouple Bone Formation and Resorption - a Novel Target for Treatment of Osteoporosis.
Osteoporosis
Interaction of spin-labeled inhibitors of the vacuolar H+-ATPase with the transmembrane Vo-sector.
Osteoporosis
Membrane-bound peptides from V-ATPase subunit a do not interact with an indole-type inhibitor.
Osteoporosis
Membrane-bound peptides mimicking transmembrane Vph1p helix 7 of yeast V-ATPase: a spectroscopic and polarity mismatch study.
Osteoporosis
Novel techniques in the development of osteoporosis drug therapy: the osteoclast ruffled-border vacuolar H(+)-ATPase as an emerging target.
Osteoporosis
Organization of the biosynthetic gene cluster for the macrolide concanamycin A in Streptomyces neyagawaensis ATCC 27449.
Osteoporosis
Targeting Reversible Disassembly as a Mechanism of Controlling V-ATPase Activity.
Osteoporosis
The Binding Site of the V-ATPase Inhibitor Apicularen Is in the Vicinity of Those for Bafilomycin and Archazolid.
Osteoporosis
The vacuolar ATPase in bone cells: a potential therapeutic target in osteoporosis.
Osteoporosis
V-ATPases and osteoclasts: ambiguous future of V-ATPases inhibitors in osteoporosis.
Osteoporosis
V-ATPases in osteoclasts: structure, function and potential inhibitors of bone resorption.
Osteosarcoma
Acid microenvironment promotes cell survival of human bone sarcoma through the activation of cIAP proteins and NF-?B pathway.
Osteosarcoma
Acridine orange used for photodynamic therapy accumulates in malignant musculoskeletal tumors depending on pH gradient.
Osteosarcoma
Bovine Milk Lactoferrin Selectively Kills Highly Metastatic Prostate Cancer PC-3 and Osteosarcoma MG-63 Cells In Vitro.
Osteosarcoma
Comparative proteomic analysis of osteosarcoma cell and human primary cultured osteoblastic cell.
Osteosarcoma
Effect of selenite on basic mitochondrial function in human osteosarcoma cells with chronic mitochondrial stress.
Osteosarcoma
Hypoxic preconditioning-induced mitochondrial protection is not disrupted in a cell model of mtDNA T8993G mutation-induced F1F0-ATP synthase defect: the role of mitochondrial permeability transition.
Osteosarcoma
The F(1)F(0) ATP synthase and mitochondrial respiratory chain complexes are present on the plasma membrane of an osteosarcoma cell line: An immunocytochemical study.
Osteosarcoma
The Inhibitor Protein (IF1) of the F1F0-ATPase Modulates Human Osteosarcoma Cell Bioenergetics.
Osteosclerosis
Lack of vacuolar proton ATPase association with the cytoskeleton in osteoclasts of osteosclerotic (oc/oc) mice.
Ovarian Neoplasms
Proton pump inhibitors enhance the effects of cytotoxic agents in chemoresistant epithelial ovarian carcinoma.
Ovarian Neoplasms
Targeting V-ATPase Isoform Restores Cisplatin Activity in Resistant Ovarian Cancer: Inhibition of Autophagy, Endosome Function, and ERK/MEK Pathway.
Ovarian Neoplasms
Vacuolar ATPase 'a2' isoform exhibits distinct cell surface accumulation and modulates matrix metalloproteinase activity in ovarian cancer.
Overweight
Mitochondrial dysfunction in the fetoplacental unit in gestational diabetes mellitus.
Pancreatic Neoplasms
Expression of 16 kDa proteolipid of vacuolar-type H(+)-ATPase in human pancreatic cancer.
Pancreatic Neoplasms
The marine natural product manzamine a targets vacuolar ATPases and inhibits autophagy in pancreatic cancer cells.
Pancreatic Neoplasms
The vacuolar-ATPase modulates matrix metalloproteinase isoforms in human pancreatic cancer.
Pancreatitis
Mitochondrial Dysfunction, Through Impaired Autophagy, Leads to Endoplasmic Reticulum Stress, Deregulated Lipid Metabolism, and Pancreatitis in Animal Models.
Paraganglioma
Potential therapeutic target for malignant paragangliomas: ATP synthase on the surface of paraganglioma cells.
Paralysis
Systemic lupus erythematosus presenting initially as hydrogen ATPase pump defects of distal renal tubular acidosis.
Parkinson Disease
?-synuclein oligomers interact with ATP synthase and open the permeability transition pore in Parkinson's disease.
Parkinson Disease
Abnormal levels of prohibitin and ATP synthase in the substantia nigra and frontal cortex in Parkinson's disease.
Parkinson Disease
Altered splicing of ATP6AP2 causes X-linked parkinsonism with spasticity (XPDS).
Parkinson Disease
Alternative mitochondrial quality control mediated by extracellular release.
Parkinson Disease
Disorders of lysosomal acidification-The emerging role of v-ATPase in aging and neurodegenerative disease.
Parkinson Disease
Glutathione s-transferase omega 1 activity is sufficient to suppress neurodegeneration in a Drosophila model of Parkinson disease.
Parkinson Disease
LRRK2 mutations impair depolarization-induced mitophagy through inhibition of mitochondrial accumulation of RAB10.
Parkinson Disease
Lysosomal Storage of Subunit c of Mitochondrial ATP Synthase in Brain-Specific Atp13a2-Deficient Mice.
Parkinson Disease
Parkinson's disease protein DJ-1 regulates ATP synthase protein components to increase neuronal process outgrowth.
Parkinson Disease
Regulation of alpha-synuclein expression by liver X receptor ligands in vitro.
Parkinson Disease
Yeast reveal a "druggable" Rsp5/Nedd4 network that ameliorates ?-synuclein toxicity in neurons.
Parkinsonian Disorders
Drug-induced parkinsonism: cinnarizine and flunarizine are potent uncouplers of the vacuolar H+-ATPase in catecholamine storage vesicles.
Pediatric Obesity
Mitochondrial ATPase subunit 6 and cytochrome B gene variations in obese Turkish children.
Pemphigoid, Bullous
Polymorphisms in the mitochondrially encoded ATP synthase 8 gene are associated with susceptibility to bullous pemphigoid in the German population.
Periodontal Diseases
Comparative analysis of the effects of a novel vacuolar adenosine 5'-triphosphatase inhibitor, FR202126, and doxycycline on bone loss caused by experimental periodontitis in rats.
Periodontitis
A novel inhibitor of vacuolar ATPase, FR202126, prevents alveolar bone destruction in experimental periodontitis in rats.
Peritonitis
Nanoparticulate vacuolar ATPase blocker exhibits potent host-targeted antiviral activity against feline coronavirus.
Peritonitis
Vacuolar (H+)-ATPase Critically Regulates Specialized Proresolving Mediator Pathways in Human M2-like Monocyte-Derived Macrophages and Has a Crucial Role in Resolution of Inflammation.
Pheochromocytoma
Potential therapeutic target for malignant paragangliomas: ATP synthase on the surface of paraganglioma cells.
Phytoplasma Disease
Silencing of ATP synthase ? reduces phytoplasma multiplication in a leafhopper vector.
Pneumocystis Infections
Alteration in expression of the rat mitochondrial ATPase 6 gene during Pneumocystis carinii infection.
Polycystic Ovary Syndrome
ATP synthase ?-subunit abnormality in pancreas islets of rats with polycystic ovary syndrome and type 2 diabetes mellitus.
Pre-Eclampsia
Placental Vacuolar ATPase Function Is a Key Link between Multiple Causes of Preeclampsia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
New haplotypes of the ATP synthase subunit 6 gene of mitochondrial DNA are associated with acute lymphoblastic leukemia in Saudi Arabia.
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
Anti-leukemic effects of the V-ATPase inhibitor Archazolid A.
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
Glucocorticoid-induced alterations in mitochondrial membrane properties and respiration in childhood acute lymphoblastic leukemia.
Prostatic Neoplasms
A novel RNA aptamer identifies plasma membrane ATP synthase beta subunit as an early marker and therapeutic target in aggressive cancer.
Prostatic Neoplasms
A novel tumor metastasis suppressor gene LASS2/TMSG1 interacts with vacuolar ATPase through its homeodomain.
Prostatic Neoplasms
Ectopic expression of the ATP synthase ? subunit on the membrane of PC-3M cells supports its potential role in prostate cancer metastasis.
Prostatic Neoplasms
Inhibition of mitochondria ATP synthase suppresses prostate cancer growth through reduced insulin-like growth factor-1 secretion by prostate stromal cells.
Prostatic Neoplasms
Inhibitors of vacuolar ATPase proton pumps inhibit human prostate cancer cell invasion and prostate-specific antigen expression and secretion.
Prostatic Neoplasms
Reduced Levels of ATP Synthase Subunit ATP5F1A Correlate with Earlier-Onset Prostate Cancer.
Prostatic Neoplasms
Silencing of a novel tumor metastasis suppressor gene LASS2/TMSG1 promotes invasion of prostate cancer cell in vitro through increase of vacuolar ATPase activity.
Prostatic Neoplasms
Silencing of LASS2/TMSG1 enhances invasion and metastasis capacity of prostate cancer cell.
Prostatic Neoplasms
Silencing of vacuolar ATPase c subunit ATP6V0C inhibits the invasion of prostate cancer cells through a LASS2/TMSG1-independent manner.
Prostatic Neoplasms
V-ATPase Inhibition Decreases Mutant Androgen Receptor Activity in Castrate-resistant Prostate Cancer.
Prostatic Neoplasms
Vacuolar H+-ATPase is down-regulated by the angiogenesis-inhibitory pigment epithelium-derived factor in metastatic prostate cancer cells.
Prostatic Neoplasms
[Silencing of vacuolar ATPase c subunit ATP6V0C inhibits invasion of prostate cancer cells].
protein-lysine desuccinylase (nad+) deficiency
SIRT5 deficiency suppresses mitochondrial ATP production and promotes AMPK activation in response to energy stress.
Proteinuria
Cisplatin-induced inhibition of receptor-mediated endocytosis of protein in the kidney.
Proteostasis Deficiencies
Osteopetrosis Mutation R444L Causes Endoplasmic Reticulum Retention and Misprocessing of Vacuolar H+-ATPase a3 Subunit.
Pulmonary Disease, Chronic Obstructive
Bioenergetic adaptation of individual human diaphragmatic myofibers to severe COPD.
Pulmonary Fibrosis
BAX inhibitor-1-associated V-ATPase glycosylation enhances collagen degradation in pulmonary fibrosis.
Quadriplegia
Neurogenic vs. Myogenic Origin of Acquired Muscle Paralysis in Intensive Care Unit (ICU) Patients: Evaluation of Different Diagnostic Methods.
Relative Energy Deficiency in Sport
In vitro proliferation and differentiation potential of bone marrow-derived mesenchymal stem cells from ovariectomized rats.
Renal Insufficiency
Mechanisms of toxicity of Cleistanthus collinus: Vacuolar ATPases are a putative target.
Reperfusion Injury
Calcium in renal cells. Modulation of calcium-dependent activation of phospholipase A2.
Reperfusion Injury
Effect of ischemic preconditioning on mitochondrial oxidative phosphorylation and high energy phosphates in rat hearts.
Reperfusion Injury
Role of energy metabolism in the preconditioned heart--a possible contribution of mitochondria.
Retinal Degeneration
Quantitative proteomics of a presymptomatic A53T alpha-synuclein Drosophila model of Parkinson disease.
Retinitis
A yeast model of the neurogenic ataxia retinitis pigmentosa (NARP) T8993G mutation in the mitochondrial ATP synthase-6 gene.
Retinitis
A yeast-based assay identifies drugs active against human mitochondrial disorders.
Retinitis
Defective mitochondrial ATPase due to rare mtDNA m.8969G>A mutation-causing lactic acidosis, intellectual disability, and poor growth.
Retinitis
Human NARP mitochondrial mutation metabolism corrected with alpha-ketoglutarate/aspartate: a potential new therapy.
Retinitis
Inefficient coupling between proton transport and ATP synthesis may be the pathogenic mechanism for NARP and Leigh syndrome resulting from the T8993G mutation in mtDNA.
Retinitis
Stability of the m.8993T->G mtDNA mutation load during human embryofetal development has implications for the feasibility of prenatal diagnosis in NARP syndrome.
Retinitis Pigmentosa
Antioxidant defence systems and generation of reactive oxygen species in osteosarcoma cells with defective mitochondria: Effect of selenium.
Retinitis Pigmentosa
ATP6 homoplasmic mutations inhibit and destabilize the human F1F0-ATP synthase without preventing enzyme assembly and oligomerization.
Retinitis Pigmentosa
Correlation between the clinical symptoms and the proportion of mitochondrial DNA carrying the 8993 point mutation in the NARP syndrome.
Retinitis Pigmentosa
Defining the impact on yeast ATP synthase of two pathogenic human mitochondrial DNA mutations, T9185C and T9191C.
Retinitis Pigmentosa
Disrupted ATP synthase activity and mitochondrial hyperpolarisation-dependent oxidative stress is associated with p66Shc phosphorylation in fibroblasts of NARP patients.
Retinitis Pigmentosa
Impaired ATP synthase assembly associated with a mutation in the human ATP synthase subunit 6 gene.
Retinitis Pigmentosa
NARP syndrome in a patient harbouring an insertion in the MT-ATP6 gene that results in a truncated protein.
Retinitis Pigmentosa
Superoxide-induced massive apoptosis in cultured skin fibroblasts harboring the neurogenic ataxia retinitis pigmentosa (NARP) mutation in the ATPase-6 gene of the mitochondrial DNA.
Retinoblastoma
Amplification of the gene encoding the alpha-subunit of the mitochondrial ATP synthase complex in a human retinoblastoma cell line.
Retinoblastoma
Mitochondrial ATP synthase alpha-subunit gene amplified in a retinoblastoma cell line maps to chromosome 18.
Retinoblastoma
Regulation of the cell cycle in response to inhibition of mitochondrial generated energy.
Rhabdomyosarcoma
Impairment of lysosomal activity as a therapeutic modality targeting cancer stem cells of embryonal rhabdomyosarcoma cell line RD.
Root Resorption
Immunolocalization of vacuolar-type H+-ATPase, cathepsin K, matrix metalloproteinase-9, and receptor activator of NFkappaB ligand in odontoclasts during physiological root resorption of human deciduous teeth.
Sarcoidosis
Identification of HLA-DR-bound peptides presented by human bronchoalveolar lavage cells in sarcoidosis.
Sarcoma
Bioenergetic properties of human sarcoma cells help define sensitivity to metabolic inhibitors.
Sarcoma
Identification of the salusin-? receptor using proteoliposomes embedded with endogenous membrane proteins.
Sarcoma
Transcriptional activation through ETS domain binding sites in the cytochrome c oxidase subunit IV gene.
Sarcoma, Ewing
Acid microenvironment promotes cell survival of human bone sarcoma through the activation of cIAP proteins and NF-?B pathway.
Sarcoma, Ewing
Impairment of lysosomal activity as a therapeutic modality targeting cancer stem cells of embryonal rhabdomyosarcoma cell line RD.
Seizures
Neurodegeneration and Epilepsy in a Zebrafish Model of CLN3 Disease (Batten Disease).
Seizures
Sustained elevation of cerebrospinal fluid glucose and lactate after a single seizure does not parallel with mitochondria energy production.
Sepsis
Circular RNA circVMA21 ameliorates lipopolysaccharide (LPS)-induced acute kidney injury by targeting the miR-199a-5p/NRP1 axis in sepsis.
Sepsis
Hypoxia-Inducible Factor-1 ? Regulates the Expression of the Mitochondrial ATPase Inhibitor Protein (IF1) in Rat Liver.
Sepsis
Suppression of mitochondrial ATPase inhibitor protein (IF1) in the liver of late septic rats.
Sepsis
[Value of ATP synthase C subunit in predicting cardiac function and outcomes of sepsis].
Sjogren's Syndrome
Absence of H(+)-ATPase in cortical collecting tubules of a patient with Sjogren's syndrome and distal renal tubular acidosis.
Small Cell Lung Carcinoma
[The expression of ABCG4, V-ATPase and clinic significance of their correlation with NSCLC.]
Smith-Magenis Syndrome
C9orf72 and smcr8 mutant mice reveal MTORC1 activation due to impaired lysosomal degradation and exocytosis.
Spastic Paraplegia, Hereditary
MitCHAP-60 and Hereditary Spastic Paraplegia SPG-13 Arise from an Inactive hsp60 Chaperonin that Fails to Fold the ATP Synthase ?-Subunit.
Spondylitis, Ankylosing
Acute Sarcomeric M-Line Disease Associated With ATP Synthase Subunit ? Autoantibodies in Ankylosing Spondylitis.
Squamous Cell Carcinoma of Head and Neck
Chemoresistance to concanamycin A1 in human oral squamous cell carcinoma is attenuated by an HDAC inhibitor partly via suppression of Bcl-2 expression.
Squamous Cell Carcinoma of Head and Neck
High glucose uptake unexpectedly is accompanied by high levels of the mitochondrial ß-F1-ATPase subunit in head and neck squamous cell carcinoma.
Squamous Cell Carcinoma of Head and Neck
Intracellular pH regulation in oral squamous cell carcinoma is mediated by increased V-ATPase activity via over-expression of the ATP6V1C1 gene.
ST Elevation Myocardial Infarction
A naturally occurring mutation in ATP synthase subunit c is associated with increased damage following hypoxia/reoxygenation in STEMI patients.
Starvation
8-Dehydrosterols induce membrane traffic and autophagy defects through V-ATPase dysfunction in Saccharomyces cerevisae.
Starvation
Acidification of vacuoles is required for autophagic degradation in the yeast, Saccharomyces cerevisiae.
Starvation
AKT Ser/Thr kinase increases V-ATPase-dependent lysosomal acidification in response to amino acid starvation in mammalian cells.
Starvation
Cellular vacuolization caused by overexpression of the PIKfyve-binding deficient Vac14(L156R) is rescued by starvation and inhibition of vacuolar-ATPase.
Starvation
Chaperone-Mediated Autophagy Upregulation Rescues Megalin Expression and Localization in Cystinotic Proximal Tubule Cells.
Starvation
Determining AMPK Activation via the Lysosomal v-ATPase-Ragulator-AXIN/LKB1 Axis.
Starvation
Dissection of autophagy in tobacco BY-2 cells under sucrose starvation conditions using the vacuolar H(+)-ATPase inhibitor concanamycin A and the autophagy-related protein Atg8.
Starvation
Expression of Manduca sexta V-ATPase genes mvB, mvG and mvd is regulated by ecdysteroids.
Starvation
Fe deficiency differentially affects the vacuolar proton pumps in cucumber and soybean roots.
Starvation
Glucose Starvation Increases V-ATPase Assembly and Activity in Mammalian Cells through AMP Kinase and Phosphatidylinositide 3-Kinase/Akt Signaling.
Starvation
Glycolytic reprogramming of macrophages activated by NOD1 and TLR4 agonists: No association with proinflammatory cytokine production in normoxia.
Starvation
Increased biomass yield of Lactococcus lactis during energetically limited growth and respiratory conditions.
Starvation
Insect midgut K(+) secretion: concerted run-down of apical/basolateral transporters with extra-/intracellular acidity.
Starvation
Physiological and comparative proteome analyses reveal low-phosphate tolerance and enhanced photosynthesis in a maize mutant owing to reinforced inorganic phosphate recycling.
Starvation
Polarization of M2 macrophages requires Lamtor1 that integrates cytokine and amino-acid signals.
Starvation
Proteomics and bioinformatics analysis reveal potential roles of cadmium-binding proteins in cadmium tolerance and accumulation of Enterobacter cloacae.
Starvation
Quantitative proteomic analysis of cell envelope preparations under iron starvation stress in Aeromonas hydrophila.
Starvation
Regulation of GlnK activity: modification, membrane sequestration and proteolysis as regulatory principles in the network of nitrogen control in Corynebacterium glutamicum.
Starvation
Regulation of V-ATPase assembly and function of V-ATPases in tumor cell invasiveness.
Starvation
Regulation of V-ATPase Assembly in Nutrient Sensing and Function of V-ATPases in Breast Cancer Metastasis.
Starvation
The contribution of Candida albicans vacuolar ATPase subunit V1B encoded by VMA2 to stress response, autophagy, and virulence is independent of environmental pH.
Starvation
The sharp phase of respiratory inhibition during amino acid starvation in Escherichia coli is RelA-dependent and associated with regulation of ATP synthase activity.
Stomach Neoplasms
Effect of pantoprazole on human gastric adenocarcinoma SGC7901 cells through regulation of phospho?LRP6 expression in Wnt/?-catenin signaling.
Stomach Neoplasms
Effects of diphyllin as a novel V-ATPase inhibitor on gastric adenocarcinoma.
Stomach Neoplasms
Expression and Transcriptional Regulation of Human ATP6V1A Gene in Gastric Cancers.
Stomach Neoplasms
HAI-178 antibody-conjugated fluorescent magnetic nanoparticles for targeted imaging and simultaneous therapy of gastric cancer.
Stomach Neoplasms
Long non-coding RNA MIF-AS1 promotes gastric cancer cell proliferation and reduces apoptosis to upregulate NDUFA4.
Stomach Neoplasms
Vacuolar H+-ATPase inhibitor induces apoptosis via lysosomal dysfunction in the human gastric cancer cell line MKN-1.
Stomach Neoplasms
[Effect of synergistic polarization macrophage modulated by N-terminal domain of a2 vacuolar ATPase and macrophage colony stimulating factor on proliferation of gastric cancer cells].
Stroke
Determination of torque generation from the power stroke of Escherichia coli F1-ATPase.
Stroke
Power Stroke Angular Velocity Profiles of Archaeal A-ATP Synthase Versus Thermophilic and Mesophilic F-ATP Synthase Molecular Motors.
Stroke
Single molecule measurements of F1-ATPase reveal an interdependence between the power stroke and the dwell duration.
Stroke
Structural basis for power stroke vs. Brownian ratchet mechanisms of motor proteins.
Synucleinopathies
Splice isoform and pharmacological studies reveal that sterol depletion relocalizes ?-synuclein and enhances its toxicity.
Tauopathies
P-Tau and Subunit c Mitochondrial ATP Synthase Accumulation in the Central Nervous System of a Woman with Hurler-Scheie Syndrome Treated with Enzyme Replacement Therapy for 12 Years.
Tetanus
Inhibitors of synaptic vesicle exocytosis reduce surface expression of postsynaptic glutamate receptors.
Thyroid Cancer, Papillary
Molecular Analysis by Gene Expression of Mitochondrial ATPase Subunits in Papillary Thyroid Cancer: Is ATP5E Transcript a Possible Early Tumor Marker?
Thyroid Neoplasms
ATP Synthase Subunit a Supports Permeability Transition in Yeast Lacking Dimerization Subunits and Modulates yPTP Conductance.
Thyroid Neoplasms
Molecular Analysis by Gene Expression of Mitochondrial ATPase Subunits in Papillary Thyroid Cancer: Is ATP5E Transcript a Possible Early Tumor Marker?
Tongue Neoplasms
Immunoproteomics reveals that cancer of the tongue and the gingivobuccal complex exhibit differential autoantibody response.
Triple Negative Breast Neoplasms
Aurovertin B exerts potent antitumor activity against triple-negative breast cancer in vivo and in vitro via regulating ATP synthase activity and DUSP1 expression.
Triple Negative Breast Neoplasms
The Vacuolar ATPase a2-subunit regulates Notch signaling in triple-negative breast cancer cells.
Trypanosomiasis, African
Isolation of F1-ATPase from the Parasitic Protist Trypanosoma brucei.
Tuberculosis
A diarylquinoline drug active on the ATP synthase of Mycobacterium tuberculosis.
Tuberculosis
A Mycobacterium tuberculosis cytochrome bd oxidase mutant is hypersensitive to bedaquiline.
Tuberculosis
ATP synthase in slow- and fast-growing mycobacteria is active in ATP synthesis and blocked in ATP hydrolysis direction.
Tuberculosis
ATP synthase, an essential enzyme in growth and multiplication is modulated by protein tyrosine phosphatase in Mycobacterium tuberculosis H37Ra.
Tuberculosis
Bedaquiline - The first ATP synthase inhibitor against multi drug resistant tuberculosis.
Tuberculosis
Bedaquiline as part of combination therapy in adults with pulmonary multi-drug resistant tuberculosis.
Tuberculosis
Bedaquiline inhibits the ATP synthase in Mycobacterium abscessus and is effective in infected zebrafish.
Tuberculosis
Biological evaluation of novel substituted chloroquinolines targeting mycobacterial ATP synthase.
Tuberculosis
Characterization of new mutations in the mycobacterial ATP synthase: New insights in the binding of the diarylquinoline TMC207 to the ATP synthase c-ring structure.
Tuberculosis
Current perspective of ATP synthase inhibitors in the management of the tuberculosis.
Tuberculosis
Design, synthesis and biological evaluation of diamino substituted cyclobut-3-ene-1,2-dione derivatives for the treatment of drug-resistant tuberculosis.
Tuberculosis
Diarylquinolines, synthesis pathways and quantitative structure--activity relationship studies leading to the discovery of TMC207.
Tuberculosis
Emergence of mmpT5 Variants during Bedaquiline Treatment of Mycobacterium intracellulare Lung Disease.
Tuberculosis
Emerging opportunities of exploiting mycobacterial electron transport chain pathway for drug-resistant tuberculosis drug discovery.
Tuberculosis
Exploring the Potential Inhibition of Candidate Drug Molecules for Clinical Investigation based on their Docking or Crystallographic Analyses against M. tuberculosis Enzyme Targets.
Tuberculosis
Genetic basis for natural and acquired resistance to the diarylquinoline R207910 in mycobacteria.
Tuberculosis
Halting ionic shuttle to disrupt the synthetic machinery-Structural and molecular insights into the inhibitory roles of Bedaquiline towards Mycobacterium tuberculosis ATP synthase in the treatment of tuberculosis.
Tuberculosis
Inhibitors of F1F0-ATP synthase enzymes for the treatment of tuberculosis and cancer.
Tuberculosis
Membrane and membrane-associated proteins in Triton X-114 extracts of Mycobacterium bovis BCG identified using a combination of gel-based and gel-free fractionation strategies.
Tuberculosis
Mode-of-action profiling reveals glutamine synthetase as a collateral metabolic vulnerability of M. tuberculosis to bedaquiline.
Tuberculosis
Molecular mechanistic insights into uncoupling of ion transport from ATP synthesis.
Tuberculosis
Mycobacterium tuberculosis Controls Phagosomal Acidification by Targeting CISH-Mediated Signaling.
Tuberculosis
Novel antibiotics targeting respiratory ATP synthesis in gram-positive pathogenic bacteria.
Tuberculosis
Novel, potent, orally bioavailable and selective mycobacterial ATP synthase inhibitors that demonstrated activity against both replicating and non-replicating M. tuberculosis.
Tuberculosis
Nutrient-starved, non-replicating Mycobacterium tuberculosis requires respiration, ATP synthase and isocitrate lyase for maintenance of ATP homeostasis and viability.
Tuberculosis
Probing the Interaction of the Diarylquinoline TMC207 with Its Target Mycobacterial ATP Synthase.
Tuberculosis
Rates and mechanisms of resistance development in Mycobacterium tuberculosis to a novel diarylquinoline ATP synthase inhibitor.
Tuberculosis
Screening of antitubercular compound library identifies novel ATP synthase inhibitors of Mycobacterium tuberculosis.
Tuberculosis
Selectivity of TMC207 towards mycobacterial ATP synthase compared with that towards the eukaryotic homologue.
Tuberculosis
Shortening Buruli Ulcer Treatment with Combination Therapy Targeting the Respiratory Chain and Exploiting Mycobacterium ulcerans Gene Decay.
Tuberculosis
Structure and function of Mycobacterium-specific components of F-ATP synthase subunits ? and ?.
Tuberculosis
Structure based identification of novel inhibitors against ATP synthase of Mycobacterium tuberculosis: A combined in silico and in vitro study.
Tuberculosis
Structure of mycobacterial ATP synthase bound to the tuberculosis drug bedaquiline.
Tuberculosis
Structure of the mycobacterial ATP synthase Fo rotor ring in complex with the anti-TB drug bedaquiline.
Tuberculosis
Targeting the ATP Synthase in Staphylococcus aureus Small Colony Variants, Streptococcus pyogenes and Pathogenic Fungi.
Tuberculosis
Terminal Respiratory Oxidases: A Targetables Vulnerability of Mycobacterial Bioenergetics?
Tuberculosis
The protonmotive force is required for maintaining ATP homeostasis and viability of hypoxic, nonreplicating Mycobacterium tuberculosis.
Tuberculosis
The stimulating role of subunit F in ATPase activity inside the A1-complex of the Methanosarcina mazei Gö1 A1AO ATP synthase.
Tuberculosis
Thiol oxidation of mitochondrial FO-c subunits: a way to switch off antimicrobial drug targets of the mitochondrial ATP synthase.
Tuberculosis
Transcriptional Inhibition of the F1F0-Type ATP Synthase Has Bactericidal Consequences on the Viability of Mycobacteria.
Tuberculosis
Variations of subunit {varepsilon} of the Mycobacterium tuberculosis F1Fo ATP synthase and a novel model for mechanism of action of the tuberculosis drug TMC207.
Tuberculosis, Multidrug-Resistant
Acquired resistance of Mycobacterium tuberculosis to bedaquiline.
Tuberculosis, Multidrug-Resistant
Bedaquiline inhibits the ATP synthase in Mycobacterium abscessus and is effective in infected zebrafish.
Tuberculosis, Multidrug-Resistant
Delayed bactericidal response of Mycobacterium tuberculosis to bedaquiline involves remodelling of bacterial metabolism.
Tuberculosis, Multidrug-Resistant
Inhibitors of F1F0-ATP synthase enzymes for the treatment of tuberculosis and cancer.
Tuberculosis, Multidrug-Resistant
Multidrug-resistant tuberculosis and culture conversion with bedaquiline.
Tuberculosis, Multidrug-Resistant
Mutations in pepQ Confer Low-Level Resistance to Bedaquiline and Clofazimine in Mycobacterium tuberculosis.
Tuberculosis, Multidrug-Resistant
Synthetic approaches towards bedaquiline and its derivatives.
Tuberculosis, Multidrug-Resistant
Terminal Respiratory Oxidases: A Targetables Vulnerability of Mycobacterial Bioenergetics?
Tuberculosis, Pulmonary
Epiregulin (EREG) and human V-ATPase (TCIRG1): genetic variation, ethnicity and pulmonary tuberculosis susceptibility in Guinea-Bissau and The Gambia.
Tuberculosis, Pulmonary
Human V-ATPase gene can protect or predispose the host to pulmonary tuberculosis.
Tuberous Sclerosis
Application of high-performance liquid chromatography-based analysis of DNA fragments to molecular carcinogenesis.
Ureteral Obstruction
H+-ATPase activity on unilateral ureteral obstruction: interaction of endogenous nitric oxide and angiotensin II.
Ureteral Obstruction
Interaction between V-ATPase B2 and (Pro) renin Receptors in Promoting the progression of Renal Tubulointerstitial Fibrosis.
Uterine Cervical Neoplasms
P-glycoprotein and Vacuolar ATPase Synergistically Confer Anthracycline Resistance to Fission Yeast and Human Cells.
Uterine Cervical Neoplasms
Proton Pump Inhibition Enhances the Cytotoxicity of Paclitaxel in Cervical Cancer.
Uterine Cervical Neoplasms
Upregulation of V-ATPase by STAT3 Activation Promotes Anoikis Resistance and Tumor Metastasis.
Ventricular Dysfunction
Human myocardial adenosine triphosphatase activities in health and heart failure.
Ventricular Fibrillation
Specific up-regulation of mitochondrial F0F1-ATPase activity after short episodes of atrial fibrillation in sheep.
vesicle-fusing atpase deficiency
v-ATPase V0 subunit d2-deficient mice exhibit impaired osteoclast fusion and increased bone formation.
Vesicular Stomatitis
Folimycin (concanamycin A), a specific inhibitor of V-ATPase, blocks intracellular translocation of the glycoprotein of vesicular stomatitis virus before arrival to the Golgi apparatus.
Virus Diseases
Antiviral efficacy of nanoparticulate vacuolar ATPase inhibitors against influenza virus infection.
Virus Diseases
F1 ATP synthase ? subunit is a putative receptor involved in white spot syndrome virus infection in shrimp by binding with viral envelope proteins VP51B and VP150.
Virus Diseases
Inhibitory and combinatorial effect of diphyllin, a v-ATPase blocker, on influenza viruses.
Virus Diseases
Japanese encephalitis virus infection in Vero cells: the involvement of intracellular acidic vesicles in the early phase of viral infection was observed with the treatment of a specific vacuolar type H+-ATPase inhibitor, bafilomycin A1.
Virus Diseases
Macrophage cytoplasmic vesicle pH gradients and vacuolar H+-ATPase activities relative to virus infection.
Virus Diseases
Serine metabolism antagonizes antiviral innate immunity by preventing ATP6V0d2-mediated YAP lysosomal degradation.
Virus Diseases
The H+-ATPase (V-ATPase): from proton pump to signaling complex in health and disease.
Virus Diseases
The proton translocation domain of cellular vacuolar ATPase provides a target for the treatment of influenza A virus infections.
Wolfram Syndrome
Vacuolar-type H+-ATPase V1A subunit is a molecular partner of Wolfram syndrome 1 (WFS1) protein, which regulates its expression and stability.
[histone h3]-lysine4 n-trimethyltransferase
deficiency
Dot1l deficiency leads to increased intercalated cells and upregulation of V-ATPase B1 in mice.
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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
0.5
ATP
purified enzyme stimulated with Na+ at pH 7.0 and 9.0
0.55
ATP
purified enzyme, Mg2+/ATP ratio maintained at 2:1
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pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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pH RANGE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY
GeneOntology No.
LITERATURE
SOURCE
-
brenda
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UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable).
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable). Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
additional information
additional information
9 subunits as calculated from DNA sequence
additional information
9 subunits as calculated from DNA sequence
additional information
9 subunits as calculated from DNA sequence
additional information
9 subunits as calculated from DNA sequence
additional information
9 subunits as calculated from DNA sequence
additional information
9 subunits as calculated from DNA sequence
additional information
9 subunits as calculated from DNA sequence
additional information
9 subunits as calculated from DNA sequence
additional information
9 subunits as calculated from DNA sequence
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TEMPERATURE STABILITY
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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STORAGE STABILITY
ORGANISM
UNIPROT
LITERATURE
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PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
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APPLICATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Ferguson Scott, F.S.; Keis Stefani, K.S.; Cook Gregory, C.G.
Biochemical and molecular characterization of a Na+-translocating F1Fo-ATPase from the thermoalkaliphilic bacterium Clostridium paradoxum
J. Bacteriol.
188
5045-5054
2006
[Clostridium] paradoxum (Q0ZS18), [Clostridium] paradoxum (Q0ZS19), [Clostridium] paradoxum (Q0ZS20), [Clostridium] paradoxum (Q0ZS21), [Clostridium] paradoxum (Q0ZS22), [Clostridium] paradoxum (Q0ZS23), [Clostridium] paradoxum (Q0ZS24), [Clostridium] paradoxum (Q0ZS25), [Clostridium] paradoxum (Q0ZS26), [Clostridium] paradoxum, [Clostridium] paradoxum DSM 7308 (Q0ZS18), [Clostridium] paradoxum DSM 7308 (Q0ZS19), [Clostridium] paradoxum DSM 7308 (Q0ZS20), [Clostridium] paradoxum DSM 7308 (Q0ZS21), [Clostridium] paradoxum DSM 7308 (Q0ZS22), [Clostridium] paradoxum DSM 7308 (Q0ZS23), [Clostridium] paradoxum DSM 7308 (Q0ZS24), [Clostridium] paradoxum DSM 7308 (Q0ZS25), [Clostridium] paradoxum DSM 7308 (Q0ZS26)
brenda
EXTERNAL LINKS (specific for EC-Number 7.1.2.2)
Transporter Classification Database (TCDB): 3.A.2.2.7, 3.A.2.1.13, 3.A.6.2.1, 3.A.2.3.3, 3.A.2.1.1, 3.A.2.2.5, 3.A.2.2.1, 3.A.2.1.14, 3.A.2.1.15, 3.A.2.3.1, 3.A.2.2.6, 3.A.2.1.7, 3.A.2.1.3, 3.A.2.2.4, 3.A.2.2.3, 3.A.2.1.4, 3.A.2.2.8, 3.A.2.1.11, 9.B.94.2.1, 3.A.2.3.2, 3.A.2.1.6, 3.A.2.1.12
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Release 2023.1 (January 2023)
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