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Information on EC - succinate dehydrogenase (electrogenic, proton-motive force generating)

for references in articles please use BRENDA:EC7.1.1.12
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IUBMB Comments
The enzyme is very similar to EC, succinate dehydrogenase, but differs by containing two heme molecules (located in the membrane anchor component) in addition to FAD and three iron-sulfur clusters. Unlike EC, this enzyme catalyses an electrogenic reaction, enabled by electron-bifurcation via the heme molecules. In the direction of succinate oxidation by menaquinone, which is endergonic, the reaction is driven by the transmembrane electrochemical proton potential. In the direction of fumarate reduction, the electrogenic electron transfer reaction is compensated by transmembrane proton transfer pathway known as the E-pathway, which results in overall electroneutrality.
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The expected taxonomic range for this enzyme is: Bacteria, Archaea
succinate:quinone oxidoreductases, quinol fumarate reductase, more
succinate + menaquinone + 2 H+[side 1] = fumarate + menaquinol + 2 H+[side 2]
show the reaction diagram
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