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The enzyme is present in a number of methanogenic archaeal genera that accumulate cyclic 2,3-bisphosphoglycerate as a thermoprotectant. Activity is stimulated by potassium ions.
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The expected taxonomic range for this enzyme is: Archaea, Bacteria
cDPG synthase, cDPGs, cpgS
, cyclic 2,3-diphosphoglycerate synthetase, cyclic diphosphoglycerate synthase, more
ATP + 2,3-diphospho-D-glycerate = ADP + phosphate + cyclic 2,3-bisphosphoglycerate
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