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Information on EC 6.5.1.1 - DNA ligase (ATP)
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6.5.1.1 DNA ligase (ATP)IUBMB Comments
The enzyme catalyses the ligation of DNA strands with 3'-hydroxyl and 5'-phosphate termini, forming a phosphodiester and sealing certain types of single-strand breaks in duplex DNA. Catalysis occurs by a three-step mechanism, starting with the activation of the enzyme by ATP, forming a phosphoramide bond between adenylate and a lysine residue. The adenylate group is then transferred to the 5'-phosphate terminus of the substrate, forming the capped structure 5'-(5'-diphosphoadenosine)-[DNA]. Finally, the enzyme catalyses a nucleophilic attack of the 3'-OH terminus on the capped terminus, which results in formation of the phosphodiester bond and release of the adenylate. RNA can also act as substrate, to some extent. cf. EC 6.5.1.2, DNA ligase (NAD+), EC 6.5.1.6, DNA ligase (ATP or NAD+), and EC 6.5.1.7, DNA ligase (ATP, ADP or GTP).
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Word Map
- 6.5.1.1
- strand
- endonuclease
- nick
-
single-stranded
- ligases
- glycosylase
-
end-joining
-
nonhomologous
- duplex
- mismatch
- polymerases
-
phosphodiester
- dna-pkcs
-
polyadp-ribose
-
topoisomerase
- parp
- 8-oxoguanine
- temozolomide
-
dna-dependent
-
o6-methylguanine-dna
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rejoin
- uracil
-
abasic
-
okazaki
-
blunt-ended
-
artemis
- fen1
- o6-methylguanine
- primase
-
o6-alkylguanine-dna
-
cross-complementing
-
tyrosyl-dna
-
overhang
-
apurinic
-
alkyltransferase
-
5'-phosphorylated
-
photolyase
-
uracil-dna
-
8-oxog
- mre11
-
mispaired
-
excises
- analysis
-
formamidopyrimidine-dna
- molecular biology
- 7,8-dihydro-8-oxoguanine
- o6-benzylguanine
- formamidopyrimidine
-
o6-alkylguanine
-
base-excision
- synthesis
-
klenow
- smurf1
The enzyme appears in viruses and cellular organisms
Reaction Schemes
+
+
=
+
+
+
+
5'-phospho-(deoxyribonucleotide)m
=
+
+
Synonyms
dna ligase, dna repair enzyme, dna ligase i, t4 dna ligase, dna ligase iv, dna ligase iii, ligase 1, dna ligase ii, polynucleotide ligase, dna ligase 1, 
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
Deoxyribonucleate ligase
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Deoxyribonucleic acid joinase
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Deoxyribonucleic acid ligase
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Deoxyribonucleic acid repair enzyme
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Deoxyribonucleic acid-joining enzyme
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Deoxyribonucleic joinase
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Deoxyribonucleic ligase
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Deoxyribonucleic repair enzyme
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Deoxyribonucleic-joining enzyme
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DNA joinase
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DNA ligase
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DNA ligase I
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DNA ligase II
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DNA ligase III
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DNA ligase IV homolog
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DNA repair enzyme
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DNA-joining enzyme
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Lig(Tk)
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Pfu DNA ligase
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Polydeoxyribonucleotide synthase (ATP)
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Polydeoxyribonucleotide synthase [ATP]
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Polynucleotide ligase
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Sealase
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SYSTEMATIC NAME
IUBMB Comments
poly(deoxyribonucleotide)-3'-hydroxyl:5'-phospho-poly(deoxyribonucleotide) ligase (ATP)
The enzyme catalyses the ligation of DNA strands with 3'-hydroxyl and 5'-phosphate termini, forming a phosphodiester and sealing certain types of single-strand breaks in duplex DNA. Catalysis occurs by a three-step mechanism, starting with the activation of the enzyme by ATP, forming a phosphoramide bond between adenylate and a lysine residue. The adenylate group is then transferred to the 5'-phosphate terminus of the substrate, forming the capped structure 5'-(5'-diphosphoadenosine)-[DNA]. Finally, the enzyme catalyses a nucleophilic attack of the 3'-OH terminus on the capped terminus, which results in formation of the phosphodiester bond and release of the adenylate. RNA can also act as substrate, to some extent. cf. EC 6.5.1.2, DNA ligase (NAD+), EC 6.5.1.6, DNA ligase (ATP or NAD+), and EC 6.5.1.7, DNA ligase (ATP, ADP or GTP).
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CAS REGISTRY NUMBER
COMMENTARY
9015-85-4
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
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METALS and IONS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Adenocarcinoma
Diagnostic correlation between the expression of the DNA repair enzyme N-methylpurine DNA glycosylase and esophageal adenocarcinoma onset: a retrospective pilot study.
Adenocarcinoma
Mitochondrial expression of the DNA repair enzyme OGG1 improves the prognosis of pancreatic ductal adenocarcinoma.
Adenocarcinoma
Prognostic and clinical significance of long non-coding RNA SNHG12 expression in various cancers.
Adenoma
Chemosensitizing effect of shRNA-mediated ERCC1 silencing on a Xuanwei lung adenocarcinoma cell line and its clinical significance.
Adenoma
Molecular mechanism of regulation of OGG1: tuberin deficiency results in cytoplasmic redistribution of transcriptional factor NF-YA.
Adenoma
Polynucleotide kinase 3' phosphatase variant, dietary variables and risk of adenoma recurrence in the Polyp Prevention Trial.
Adenoviridae Infections
Adenovirus E4 34k and E1b 55k oncoproteins target host DNA ligase IV for proteasomal degradation.
Adenoviridae Infections
E1B 55k-independent dissociation of the DNA ligase IV/XRCC4 complex by E4 34k during adenovirus infection.
Adenoviridae Infections
The ?2 helix in the DNA ligase IV BRCT-1 domain is required for targeted degradation of ligase IV during adenovirus infection.
African Swine Fever
Contributions of an Endonuclease IV Homologue to DNA Repair in the African Swine Fever Virus.
African Swine Fever
Structure of the error-prone DNA ligase of African swine fever virus identifies critical active site residues.
African Swine Fever
Use of damaged DNA and dNTP substrates by the error-prone DNA polymerase X from African swine fever virus.
Alzheimer Disease
Bayer-Activities of Daily Living Scale in Mild and Moderate Dementia of the Alzheimer Type.
Alzheimer Disease
Organelle-specific autophagy in inflammatory diseases: a potential therapeutic target underlying the quality control of multiple organelles.
Amyotrophic Lateral Sclerosis
Mutant AP endonuclease in patients with amyotrophic lateral sclerosis.
Amyotrophic Lateral Sclerosis
Organelle-specific autophagy in inflammatory diseases: a potential therapeutic target underlying the quality control of multiple organelles.
Anaplasmosis
[Cytogenetic, kariopathological and morphological abnormalities of spermatozoa and urothelial cells in human granulocytic anaplasmosis depending on polymorphism of the gene of DNA ligase IV].
Angina Pectoris
Natural compound methyl protodioscin protects rat brain from ischemia/reperfusion injury through regulation of Mul1/SOD2 pathway.
Angina, Stable
DNA damage and repair in patients with coronary artery disease: Correlation with plaque morphology using optical coherence tomography (DECODE study).
Apraxias
A new XRCC1-containing complex and its role in cellular survival of methyl methanesulfonate treatment.
Apraxias
Molecular underpinnings of Aprataxin RNA/DNA deadenylase function and dysfunction in neurological disease.
Arthritis, Rheumatoid
Microsatellite instability and suppressed DNA repair enzyme expression in rheumatoid arthritis.
Astrocytoma
Immunohistochemical detection of the DNA repair enzyme O6-methylguanine-DNA methyltransferase in formalin-fixed, paraffin-embedded astrocytomas.
Ataxia
A new XRCC1-containing complex and its role in cellular survival of methyl methanesulfonate treatment.
Ataxia
Molecular underpinnings of Aprataxin RNA/DNA deadenylase function and dysfunction in neurological disease.
Ataxia Telangiectasia
Accelerated telomere shortening and telomere abnormalities in radiosensitive cell lines.
Ataxia Telangiectasia
Agrobacterium T-DNA integration into the plant genome can occur without the activity of key non-homologous end-joining proteins.
Ataxia Telangiectasia
DNA Damage Response Signals Transduce Stress From Rheumatoid Arthritis Risk Factors Into T Cell Dysfunction.
Ataxia Telangiectasia
DNA repair enzyme deficiency and in vitro complementation of the enzyme activity in cell-free extracts from ataxia telangiectasia fibroblasts.
Ataxia Telangiectasia
DNA Repair Syndromes and Cancer: Insights Into Genetics and Phenotype Patterns.
Ataxia Telangiectasia
Four radiation hypersensitivity cases and their implications for clinical radiotherapy.
Ataxia Telangiectasia
Indicators of late normal tissue response after radiotherapy for head and neck cancer: fibroblasts, lymphocytes, genetics, DNA repair, and chromosome aberrations.
Ataxia Telangiectasia
Insufficiency of DNA repair enzyme ATM promotes naive CD4 T-cell loss in chronic hepatitis C virus infection.
Ataxia Telangiectasia
Low levels of endogenous or X-ray-induced DNA double-strand breaks activate apoptosis in adult neural stem cells.
Ataxia Telangiectasia
Measurement of DNA polymerase beta in skin fibroblast cell lines from patients with ataxia telangiectasia.
Ataxia Telangiectasia
Non-homologous end joining in class switch recombination: the beginning of the end.
Ataxia Telangiectasia
Outcome of hematopoietic cell transplantation for DNA double-strand break repair disorders.
Ataxia Telangiectasia
Primary immunodeficiency syndromes associated with defective DNA double-strand break repair.
Ataxia Telangiectasia
Rubella Virus-Associated Cutaneous Granulomatous Disease: a Unique Complication in Immune-Deficient Patients, Not Limited to DNA Repair Disorders.
Ataxia Telangiectasia
Successful bone marrow transplantation in a patient with DNA ligase IV deficiency and bone marrow failure.
Ataxia Telangiectasia
V(D)J recombination in ataxia telangiectasia, Bloom's syndrome, and a DNA ligase I-associated immunodeficiency disorder.
Bacterial Infections
Small-Molecule Inhibitor of 8-Oxoguanine DNA Glycosylase 1 Regulates Inflammatory Responses during Pseudomonas aeruginosa Infection.
Bloom Syndrome
Biochemical properties of mammalian DNA ligase I and the molecular defect in Bloom's syndrome.
Bloom Syndrome
Characterization of the XRCC1-DNA ligase III complex in vitro and its absence from mutant hamster cells.
Bloom Syndrome
Comet assay analysis of repair of DNA strand breaks in normal and deficient human cells exposed to radiations and chemicals. Evidence for a repair pathway specificity of DNA ligation.
Bloom Syndrome
Defective DNA ligase I in Bloom's syndrome cells. Simultaneous analysis using immunoblotting and the ligase-[32P]AMP adduct assay.
Bloom Syndrome
DNA ligase activity in human cell lines from normal donors and Bloom's syndrome patients.
Bloom Syndrome
DNA ligase I is required for fetal liver erythropoiesis but is not essential for mammalian cell viability.
Bloom Syndrome
DNA ligase III is the major high molecular weight DNA joining activity in SV40-transformed human fibroblasts: normal levels of DNA ligase III activity in Bloom syndrome cells.
Bloom Syndrome
Expression of a DNA-ligase-stimulatory factor in Bloom's syndrome cell line GM1492.
Bloom Syndrome
Fingerprinting of near-homogeneous DNA ligase I and II from human cells. Similarity of their AMP-binding domains.
Bloom Syndrome
Growth retardation and immunodeficiency in a patient with mutations in the DNA ligase I gene.
Bloom Syndrome
Loss of the bloom syndrome helicase increases DNA ligase 4-independent genome rearrangements and tumorigenesis in aging Drosophila.
Bloom Syndrome
Mammalian DNA ligase III: molecular cloning, chromosomal localization, and expression in spermatocytes undergoing meiotic recombination.
Bloom Syndrome
Non-homologous end joining, but not homologous recombination, enables survival for cells exposed to a histone deacetylase inhibitor.
Bloom Syndrome
Phenotypic correction of a human cell line (46BR) with aberrant DNA ligase I activity.
Bloom Syndrome
Relation between the human fibroblast strain 46BR and cell lines representative of Bloom's syndrome.
Bloom Syndrome
Rescue of the adeno-associated virus 2 genome correlates with alterations in DNA-modifying enzymes in human cells.
Bloom Syndrome
Two types of DNA ligase I activity in lymphoblastoid cells from patients with Bloom's syndrome.
Bloom Syndrome
V(D)J recombination in ataxia telangiectasia, Bloom's syndrome, and a DNA ligase I-associated immunodeficiency disorder.
Bloom Syndrome
Vaccinia DNA ligase complements Saccharomyces cerevisiae cdc9, localizes in cytoplasmic factories and affects virulence and virus sensitivity to DNA damaging agents.
Bone Marrow Failure Disorders
Allogeneic hematopoietic stem cell transplantation in two brothers with DNA ligase IV deficiency: a case report and review of the literature.
Bone Marrow Failure Disorders
Failing to Make Ends Meet: The Broad Clinical Spectrum of DNA Ligase IV Deficiency. Case Series and Review of the Literature.
Bone Marrow Failure Disorders
Successful bone marrow transplantation in a patient with DNA ligase IV deficiency and bone marrow failure.
Brain Injuries
Interaction between inducible nitric oxide synthase and poly(ADP-ribose) polymerase in focal ischemic brain injury.
Brain Injuries
Mitochondrial E3 ubiquitin ligase 1 promotes brain injury by disturbing mitochondrial dynamics in a rat model of ischemic stroke.
Brain Ischemia
Circular RNA circ_HECTD1 regulates cell injury after cerebral infarction by miR-27a-3p/FSTL1 axis.
Brain Ischemia
Neuroprotective effects of an antioxidant in cortical cerebral ischemia: prevention of early reduction of the apurinic/apyrimidinic endonuclease DNA repair enzyme.
Brain Neoplasms
Next generation sequencing revealed DNA ligase IV deficiency in a "developmentally normal" patient with massive brain Epstein-Barr virus-positive diffuse large B-cell lymphoma.
Brain Neoplasms
Novel dopamine receptor 3 antagonists inhibit the growth of primary and temozolomide resistant glioblastoma cells.
Brain Neoplasms
p53 mutations, O6-alkylguanine DNA alkyltransferase activity, and sensitivity to procarbazine in human brain tumors.
Brain Neoplasms
[Study on potentiation of nitrosourea-cytotoxicity by DNA repair enzyme inhibitors in human brain tumor cells]
Breast Neoplasms
A Novel Benzocoumarin-Stilbene Hybrid as a DNA ligase I inhibitor with in vitro and in vivo anti-tumor activity in breast cancer models.
Breast Neoplasms
Absence of the DNA repair enzyme human 8-oxoguanine glycosylase is associated with an aggressive breast cancer phenotype.
Breast Neoplasms
Altered expression of the DNA repair protein, N-methylpurine-DNA glycosylase (MPG) in breast cancer.
Breast Neoplasms
Co-enzyme Q10, riboflavin and niacin supplementation on alteration of DNA repair enzyme and DNA methylation in breast cancer patients undergoing tamoxifen therapy.
Breast Neoplasms
Defective repair of oxidative dna damage in triple-negative breast cancer confers sensitivity to inhibition of poly(ADP-ribose) polymerase.
Breast Neoplasms
Development of non-electrophoretic assay method for DNA ligases and its application to screening of chemical inhibitors of DNA ligase I.
Breast Neoplasms
DNA Ligase IV Prevents Replication Fork Stalling and Promotes Cellular Proliferation in Triple Negative Breast Cancer.
Breast Neoplasms
Dynamin impacts homology-directed repair and breast cancer response to chemotherapy.
Breast Neoplasms
Fluorescent oligonucleotides can serve as suitable alternatives to radiolabeled oligonucleotides.
Breast Neoplasms
Genetic polymorphisms in the DNA repair enzyme ERCC2 and breast tumour risk in a Chinese population.
Breast Neoplasms
Induced in vivo knockdown of the Brca1 gene in skeletal muscle results in skeletal muscle weakness.
Breast Neoplasms
Mitochondrial DNA Repair through OGG1 Activity Attenuates Breast Cancer Progression and Metastasis.
Breast Neoplasms
Polymorphism of the DNA repair enzyme XRCC1 is associated with treatment prediction in anthracycline and cyclophosphamide/methotrexate/5-fluorouracil-based chemotherapy of patients with primary invasive breast cancer.
Breast Neoplasms
Polymorphisms in the DNA repair enzyme XPD are associated with increased levels of PAH-DNA adducts in a case-control study of breast cancer.
Breast Neoplasms
Radiosensitization of orthotopic GIC-driven glioblastoma by doxycycline causes skin damage.
Breast Neoplasms
Reduced DNA repair capacity in breast cancer patients and unaffected individuals from breast cancer families.
Breast Neoplasms
Regulation of expression of N-methylpurine DNA glycosylase in human mammary epithelial cells: role of transcription factor AP-2.
Breast Neoplasms
SCR7 is neither a selective nor a potent inhibitor of human DNA ligase IV.
Breast Neoplasms
WW domain containing E3 ubiquitin protein ligase 1 targets the full-length ErbB4 for ubiquitin-mediated degradation in breast cancer.
Breast Neoplasms
[Report on the first year of the activity of the National Oncological RD Consortium]
Burkitt Lymphoma
The cytotoxicity of DNA carboxymethylation and methylation by the model carboxymethylating agent azaserine in human cells.
Carcinogenesis
Association between O6-alkylguanine-DNA-alkyltransferase activity in peripheral blood lymphocytes and bronchial epithelial cells.
Carcinogenesis
Associations among smoking, MGMT hypermethylation, TP53-mutations, and relapse in head and neck squamous cell carcinoma.
Carcinogenesis
DNA polymerase beta overexpression stimulates the Rad51-dependent homologous recombination in mammalian cells.
Carcinogenesis
Fluorescence Probes for ALKBH2 Allow the Measurement of DNA Alkylation Repair and Drug Resistance Responses.
Carcinogenesis
Formation and repair of DNA adducts in vinyl chloride- and vinyl fluoride-induced carcinogenesis.
Carcinogenesis
HACE1 reduces oxidative stress and mutant Huntingtin toxicity by promoting the NRF2 response.
Carcinogenesis
Impaired nonhomologous end-joining provokes soft tissue sarcomas harboring chromosomal translocations, amplifications, and deletions.
Carcinogenesis
Implication of a Chromosome 15q15.2 Locus in Regulating UBR1 and Predisposing Smokers to MGMT Methylation in Lung.
Carcinogenesis
In vivo positive mutagenicity of 1,4-dioxane and quantitative analysis of its mutagenicity and carcinogenicity in rats.
Carcinogenesis
Increased susceptibility of chronic ulcerative colitis-induced carcinoma development in DNA repair enzyme Ogg1 deficient mice.
Carcinogenesis
Influence of fatty acid synthase inhibitor orlistat on the DNA repair enzyme O6-methylguanine-DNA methyltransferase in human normal or malignant cells in vitro.
Carcinogenesis
Loss of the bloom syndrome helicase increases DNA ligase 4-independent genome rearrangements and tumorigenesis in aging Drosophila.
Carcinogenesis
Mitochondrial DNA Repair through OGG1 Activity Attenuates Breast Cancer Progression and Metastasis.
Carcinogenesis
Novel mechanism of reducing tumourigenesis: upregulation of the DNA repair enzyme OGG1 by rapamycin-mediated AMPK activation and mTOR inhibition.
Carcinogenesis
The MBD4 Glu346Lys polymorphism is associated with the risk of cervical cancer in a Chinese population.
Carcinoma
Antitumor activity and induction of apoptosis by water-soluble derivatives of 7 beta-hydroxycholesterol in human colon carcinoma cell lines.
Carcinoma
Assessment of P-glycoprotein, glutathione-based detoxifying enzymes and O6-alkylguanine-DNA alkyltransferase as potential indicators of constitutive drug resistance in human colorectal tumors.
Carcinoma
Concomitant loss of mitochondria and the DNA repair protein hOGG1 in clear cell carcinoma of the kidney.
Carcinoma
DNA repair enzyme polymorphisms and oxidative stress in a Turkish population with gastric carcinoma.
Carcinoma
Effects of cisplatin on expression of DNA ligases in MiaPaCa human pancreatic cancer cells.
Carcinoma
Expression and clinical significance of the DNA repair enzyme MYH in esophageal squamous cell carcinoma.
Carcinoma
Increased susceptibility of chronic ulcerative colitis-induced carcinoma development in DNA repair enzyme Ogg1 deficient mice.
Carcinoma
Levels of the DNA repair enzyme human apurinic/apyrimidinic endonuclease (APE1, APEX, Ref-1) are associated with the intrinsic radiosensitivity of cervical cancers.
Carcinoma
Loss of expression of DNA repair enzyme MGMT in oral leukoplakia and early oral squamous cell carcinoma. A prognostic tool?
Carcinoma
Molecular mechanism of regulation of OGG1: tuberin deficiency results in cytoplasmic redistribution of transcriptional factor NF-YA.
Carcinoma
Nonhomologous end joining repair pathway molecules as predictive biomarkers for patients with oral squamous cell carcinoma.
Carcinoma
Prognostic and clinical significance of long non-coding RNA SNHG12 expression in various cancers.
Carcinoma
SNPs of GSTM1, T1, P1, epoxide hydrolase and DNA repair enzyme XRCC1 and risk of urinary transitional cell carcinoma in southwestern Taiwan.
Carcinoma
Study of AP endonuclease (APEX1/REF1), a DNA repair enzyme, in gallbladder carcinoma.
Carcinoma
WW domain-containing E3 ubiquitin protein ligase 1 depletion evokes antitumor effect in cutaneous squamous cell carcinoma by inhibiting signal transducer and activator of transcription 3 signaling pathway.
Carcinoma, Hepatocellular
Characterisation of the DNA repair enzyme for O(6)-methylguanine in cirrhosis.
Carcinoma, Hepatocellular
Correlations of HACE1 expression with pathological stages, CT features and prognosis of hepatocellular carcinoma patients.
Carcinoma, Hepatocellular
Decreased mitochondrial OGG1 expression is linked to mitochondrial defects and delayed hepatoma cell growth.
Carcinoma, Hepatocellular
Expression of DNA repair enzyme hMTH1 mRNA and protein in hepatocellular carcinoma.
Carcinoma, Hepatocellular
Increased activity of polynucleotide ligase from rat hepatoma induced by N-2-fluorenylacetamide.
Carcinoma, Hepatocellular
Prognostic and clinical significance of long non-coding RNA SNHG12 expression in various cancers.
Carcinoma, Hepatocellular
The effects of HBx gene on the expression of DNA repair enzymes hOGG1 and hMYHalpha mRNA in HepG2 cells.
Carcinoma, Hepatocellular
Ubiquitination of UVRAG by SMURF1 promotes autophagosome maturation and inhibits hepatocellular carcinoma growth.
Carcinoma, Non-Small-Cell Lung
A high-throughput screen identifies PARP1/2 inhibitors as a potential therapy for ERCC1-deficient non-small cell lung cancer.
Carcinoma, Non-Small-Cell Lung
E3 ubiquitin ligase HECW1 promotes the metastasis of non-small cell lung cancer cells through mediating the ubiquitination of Smad4.
Carcinoma, Non-Small-Cell Lung
Relationship between genetic polymorphisms of DNA ligase 1 and non-small cell lung cancer susceptibility and radiosensitivity.
Carcinoma, Non-Small-Cell Lung
The oncogenic RNA-binding protein SRSF1 regulates LIG1 in non-small cell lung cancer.
Carcinoma, Ovarian Epithelial
Ligase 1 is a predictor of platinum resistance and its blockade is synthetically lethal in XRCC1 deficient epithelial ovarian cancers.
Carcinoma, Ovarian Epithelial
The Prognostic Relevance of Poly (ADP-Ribose) Polymerase Expression in Ovarian Cancer Tissue of Wild Type and BRCA-Mutation Carrier Patients.
Carcinoma, Renal Cell
Concomitant loss of mitochondria and the DNA repair protein hOGG1 in clear cell carcinoma of the kidney.
Carcinoma, Squamous Cell
DNA double-strand break repair, DNA-PK, and DNA ligases in two human squamous carcinoma cell lines with different radiosensitivity.
Carcinoma, Squamous Cell
Prognostic and clinical significance of long non-coding RNA SNHG12 expression in various cancers.
Carcinoma, Squamous Cell
WW domain-containing E3 ubiquitin protein ligase 1 depletion evokes antitumor effect in cutaneous squamous cell carcinoma by inhibiting signal transducer and activator of transcription 3 signaling pathway.
Carcinoma, Transitional Cell
SNPs of GSTM1, T1, P1, epoxide hydrolase and DNA repair enzyme XRCC1 and risk of urinary transitional cell carcinoma in southwestern Taiwan.
Cataract
Polymorphisms of the DNA repair genes XPD and XRCC1 and the risk of age-related cataract development in Han Chinese.
Cataract
[Explore the genotype characteristics of DNA repair enzyme XRCC1 and XPD in the lens epithelium associated with free radical level in the age-related cataract patients].
Cerebellar Ataxia
Restoration of nuclear-import failure caused by triple A syndrome and oxidative stress.
Cheilitis
DNA Repair Enzyme Containing Lip Balm for the Treatment of Actinic Cheilitis: A Pilot Study
Cholangiocarcinoma
Impaired antioxidant enzyme activity and increased DNA repair enzyme expression in hamster liver tissues related to cholangiocarcinoma development.
Colonic Neoplasms
Effects of Watermelon Powder and l-arginine Supplementation on Azoxymethane-Induced Colon Carcinogenesis in Rats.
Colonic Neoplasms
Epigenetic Targeting of Transforming Growth Factor beta Receptor II and Implications for Cancer Therapy.
Colonic Neoplasms
Prognostic and clinical significance of long non-coding RNA SNHG12 expression in various cancers.
Colorectal Neoplasms
A carboxy terminal domain of the hMSH-2 gene product is sufficient for binding specific mismatched oligonucleotides.
Colorectal Neoplasms
Altered regulation of DNA ligase IV activity by aberrant promoter DNA methylation and gene amplification in colorectal cancer.
Colorectal Neoplasms
B-cell lymphoma 2 is associated with advanced tumor grade and clinical stage, and reduced overall survival in young Chinese patients with colorectal carcinoma.
Colorectal Neoplasms
Inheritance of the 194Trp and the 399Gln variant alleles of the DNA repair gene XRCC1 are associated with increased risk of early-onset colorectal carcinoma in Egypt.
Colorectal Neoplasms
MUTYH-associated polyposis carcinomas frequently lose HLA class I expression - a common event amongst DNA-repair-deficient colorectal cancers.
Colorectal Neoplasms
Promoter CpG Island Hypermethylation of the DNA Repair Enzyme MGMT Predicts Clinical Response to Dacarbazine in a Phase II Study for Metastatic Colorectal Cancer.
Colorectal Neoplasms
The value of XPD and XRCC1 genotype polymorphisms to predict clinical outcome in metastatic colorectal carcinoma patients with irinotecan-based regimens.
Decompression Sickness
The high-mobility group protein T160 binds to both linear and cruciform DNA and mediates DNA bending as determined by ring closure.
Dementia
Bayer-Activities of Daily Living Scale in Mild and Moderate Dementia of the Alzheimer Type.
Dementia
Generic quality of life assessment in dementia patients: a prospective cohort study.
Dementia
Spanish version of the Bayer Activities of Daily Living scale in mild cognitive impairment and mild Alzheimer disease: discriminant and concurrent validity.
Dementia
The Bayer-Activities of Daily Living Scale (B-ADL): results from a validation study in three European countries.
Diabetes Mellitus
Poly(ADP-ribose) polymerase inhibition reverses nitrergic neurovascular dysfunctions in penile erectile tissue from streptozotocin-diabetic mice.
Diabetes Mellitus, Type 1
European Nicotinamide Diabetes Intervention Trial (ENDIT): a randomised controlled trial of intervention before the onset of type 1 diabetes.
Diabetes Mellitus, Type 2
Islet expression of the DNA repair enzyme 8-oxoguanosine DNA glycosylase (Ogg1) in human type 2 diabetes.
dna ligase (atp) deficiency
A case report of an adolescent with ligase-4 deficiency and the potential dangers of ionizing radiation in this rare patient population.
dna ligase (atp) deficiency
A novel mutation in a family with DNA ligase IV deficiency syndrome.
dna ligase (atp) deficiency
Allogeneic hematopoietic stem cell transplantation in two brothers with DNA ligase IV deficiency: a case report and review of the literature.
dna ligase (atp) deficiency
Application of a radiosensitivity flow assay in a patient with DNA ligase 4 deficiency.
dna ligase (atp) deficiency
Association of a possible DNA ligase deficiency with T-cell acute leukemia.
dna ligase (atp) deficiency
Biallelic mutations in DNA ligase 1 underlie a spectrum of immune deficiencies.
dna ligase (atp) deficiency
Correction to: Allogeneic hematopoietic stem cell transplantation in two brothers with DNA ligase IV deficiency: a case report and review of the literature.
dna ligase (atp) deficiency
Defective neurogenesis resulting from DNA ligase IV deficiency requires Atm.
dna ligase (atp) deficiency
Defects in DNA ligase I trigger PCNA ubiquitylation at Lys 107.
dna ligase (atp) deficiency
DNA ligase gene disruptions can depress viral growth and replication in poxvirus-infected cells.
dna ligase (atp) deficiency
DNA ligase I deficiency leads to replication-dependent DNA damage and impacts cell morphology without blocking cell cycle progression.
dna ligase (atp) deficiency
DNA ligase I null mouse cells show normal DNA repair activity but altered DNA replication and reduced genome stability.
dna ligase (atp) deficiency
DNA Ligase IV Deficiency Identified by Chance Following Vaccine-Derived Rubella Virus Infection.
dna ligase (atp) deficiency
DNA ligase IV deficiency in mice leads to defective neurogenesis and embryonic lethality via the p53 pathway.
dna ligase (atp) deficiency
DNA ligase IV deficiency: Immunoglobulin class deficiency depends on the genotype.
dna ligase (atp) deficiency
DNA repair enzyme deficiency and in vitro complementation of the enzyme activity in cell-free extracts from ataxia telangiectasia fibroblasts.
dna ligase (atp) deficiency
DNA repair patch-mediated double strand DNA break formation in human cells.
dna ligase (atp) deficiency
Effect of chloramphenicol and the recB gene product on DNA metabolism in Escherichia coli K12 strains defective in DNA ligase.
dna ligase (atp) deficiency
Epstein-Barr virus-independent diffuse large B-cell lymphoma in DNA ligase 4 deficiency.
dna ligase (atp) deficiency
Failing to Make Ends Meet: The Broad Clinical Spectrum of DNA Ligase IV Deficiency. Case Series and Review of the Literature.
dna ligase (atp) deficiency
Haematopoietic Stem Cell Transplantation for DNA Ligase 1 Deficiency.
dna ligase (atp) deficiency
Induction of error-prone repair as a consequence of DNA ligase deficiency in Escherichia coli.
dna ligase (atp) deficiency
Molecular and immunological characterization of DNA ligase IV deficiency.
dna ligase (atp) deficiency
Multiple pathways of DNA double-strand break processing in a mutant Indian muntjac cell line.
dna ligase (atp) deficiency
Newborn screening using TREC/KREC assay for severe T and B cell lymphopenia in Iran.
dna ligase (atp) deficiency
Next generation sequencing revealed DNA ligase IV deficiency in a "developmentally normal" patient with massive brain Epstein-Barr virus-positive diffuse large B-cell lymphoma.
dna ligase (atp) deficiency
Normal V(D)J coding junction formation in DNA ligase I deficiency syndromes.
dna ligase (atp) deficiency
Outcome of hematopoietic cell transplantation for DNA double-strand break repair disorders.
dna ligase (atp) deficiency
Partial complementation of a DNA ligase I deficiency by DNA ligase III and its impact on cell survival and telomere stability in mammalian cells.
dna ligase (atp) deficiency
Replication failure, genome instability, and increased cancer susceptibility in mice with a point mutation in the DNA ligase I gene.
dna ligase (atp) deficiency
Rescue of the adeno-associated virus 2 genome correlates with alterations in DNA-modifying enzymes in human cells.
dna ligase (atp) deficiency
Rubella Virus-Associated Cutaneous Granulomatous Disease: a Unique Complication in Immune-Deficient Patients, Not Limited to DNA Repair Disorders.
dna ligase (atp) deficiency
Successful bone marrow transplantation in a patient with DNA ligase IV deficiency and bone marrow failure.
DNA Repair-Deficiency Disorders
Characterisation of the DNA repair enzyme for O(6)-methylguanine in cirrhosis.
Enterovirus Infections
Divergent Requirement for a DNA Repair Enzyme during Enterovirus Infections.
Esophageal Squamous Cell Carcinoma
Expression and clinical significance of the DNA repair enzyme MYH in esophageal squamous cell carcinoma.
Fanconi Anemia
Accelerated telomere shortening and telomere abnormalities in radiosensitive cell lines.
Fatty Liver
Oval cells compensate for damage and replicative senescence of mature hepatocytes in mice with fatty liver disease.
Fatty Liver
Oxidative DNA damage and DNA repair enzyme expression are inversely related in murine models of fatty liver disease.
Fatty Liver, Alcoholic
Protective Effect of SMAD-Specific E3 Ubiquitin Protein Ligase 1 in Alcoholic Steatohepatitis in Mice.
Fibrosarcoma
DNA ligase III is degraded by calpain during cell death induced by DNA-damaging agents.
Fibrosarcoma
Response of DNA repair enzymes in murine fibrosarcoma, lymphosarcoma and ascites cells following gamma irradiation.
Fowlpox
Deletion of fowlpox virus homologues of vaccinia virus genes between the 3 beta-hydroxysteroid dehydrogenase (A44L) and DNA ligase (A50R) genes.
Fowlpox
Fowlpox virus encodes a novel DNA repair enzyme, CPD-photolyase, that restores infectivity of UV light-damaged virus.
Fowlpox
The DNA repair enzyme, CPD-photolyase restores the infectivity of UV-damaged fowlpox virus isolated from infected scabs of chickens.
Frontotemporal Dementia
Organelle-specific autophagy in inflammatory diseases: a potential therapeutic target underlying the quality control of multiple organelles.
Gallbladder Neoplasms
Rac GTPase activating protein 1 promotes gallbladder cancer via binding DNA ligase 3 to reduce apoptosis.
Genetic Diseases, Inborn
Cloning, overexpression and nucleotide sequence of a thermostable DNA ligase-encoding gene.
Genetic Diseases, Inborn
DNA ligase activity in human cell lines from normal donors and Bloom's syndrome patients.
Genetic Diseases, Inborn
DNA LIGASE IV SYNDROME: A RARE CAUSE OF GROWTH FAILURE & HYPOGONADISM.
Genetic Diseases, Inborn
The function of poly (ADP-ribosylation) in DNA breakage and rejoining.
Glioblastoma
4-Acetylantrocamol LT3 Inhibits Glioblastoma Cell Growth and Downregulates DNA Repair Enzyme O6-Methylguanine-DNA Methyltransferase.
Glioblastoma
A MDR1 (ABCB1) gene single nucleotide polymorphism predicts outcome of temozolomide treatment in glioblastoma patients.
Glioblastoma
A methylation-specific and SYBR-green-based quantitative polymerase chain reaction technique for O6-methylguanine DNA methyltransferase promoter methylation analysis.
Glioblastoma
Association of Maximal Extent of Resection of Contrast-Enhanced and Non-Contrast-Enhanced Tumor With Survival Within Molecular Subgroups of Patients With Newly Diagnosed Glioblastoma.
Glioblastoma
DNA repair enzyme expression and differential response to temozolomide in a patient with both glioblastoma and metastatic pancreatic neuroendocrine tumor.
Glioblastoma
Effect of chemotherapy-induced DNA repair on oncolytic herpes simplex viral replication.
Glioblastoma
Eradication of LIG4-deficient glioblastoma cells by the combination of PARP inhibitor and alkylating agent.
Glioblastoma
IKBKE enhances TMZ-chemoresistance through upregulation of MGMT expression in glioblastoma.
Glioblastoma
In human glioblastomas transcript elongation by alternative polyadenylation and miRNA targeting is a potent mechanism of MGMT silencing.
Glioblastoma
Intratumoral heterogeneity identified at the epigenetic, genetic and transcriptional level in glioblastoma.
Glioblastoma
MGMT gene promoter methylation correlates with tolerance of temozolomide treatment in melanoma but not with clinical outcome.
Glioblastoma
Novel dopamine receptor 3 antagonists inhibit the growth of primary and temozolomide resistant glioblastoma cells.
Glioblastoma
O6-methyl-guanine-DNA methyltransferase methylation in serum and tumor DNA predicts response to 1,3-bis(2-chloroethyl)-1-nitrosourea but not to temozolamide plus cisplatin in glioblastoma multiforme.
Glioblastoma
Outlining involvement of stem cell program in regulation of O6-methylguanine DNA methyltransferase and development of temozolomide resistance in glioblastoma: An Editorial Highlight for 'Transcriptional control of O6 -methylguanine DNA methyltransferase expression and temozolomide resistance in glioblastoma' on page 780.
Glioblastoma
Overcoming Resistance of Glioblastoma to Conventional Cytotoxic Therapies by the Addition of PARP Inhibitors.
Glioblastoma
Prognostic Relevance of Tumor Purity and Interaction with MGMT Methylation in Glioblastoma.
Glioblastoma
TRIM24 promotes glioma progression and enhances chemoresistance through activation of the PI3K/Akt signaling pathway.
Glioma
Acetoaminophen-induced accumulation of 8-oxodeoxyguanosine through reduction of Ogg1 DNA repair enzyme in C6 glioma cells.
Glioma
Adenovirus-based strategies overcome temozolomide resistance by silencing the O6-methylguanine-DNA methyltransferase promoter.
Glioma
CpG island hypermethylation of the DNA repair enzyme methyltransferase predicts response to temozolomide in primary gliomas.
Glioma
Enhanced repair of a cisplatin-damaged reporter chloramphenicol-O-acetyltransferase gene and altered activities of DNA polymerases alpha and beta, and DNA ligase in cells of a human malignant glioma following in vivo cisplatin therapy.
Glioma
Frequent promoter hypermethylation and low expression of the MGMT gene in oligodendroglial tumors.
Glioma
MGMT repletion after treatment of glioblastoma cells with temozolomide and O6-benzylguanine implicates NF?B and mutant p53.
Glioma
O?-methylguanine-DNA methyltransferase promoter methylation in 45 primary central nervous system lymphomas: quantitative assessment of methylation and response to temozolomide treatment.
Glioma
Oxidative stress induces apoptosis in C6 glioma cells: involvement of mitogen-activated protein kinases and nuclear factor kappa B.
Glioma
Stable expression in rat glioma cells of sense and antisense nucleic acids to a human multifunctional DNA repair enzyme, APEX nuclease.
Glioma
[Circumvention of ACNU-resistance in rat glioma cells by pretreatment with O6-methylguanine]
Glomerulonephritis, IGA
Changes E3 ubiquitin protein ligase 1 gene mRNA expression correlated with IgA1 glycosylation in patients with IgA nephropathy.
Gonorrhea
The prevalence of urinary tract infections and sexually transmitted disease in women with symptoms of a simple urinary tract infection stratified by low colony count criteria.
Granuloma
Rubella Virus-Associated Cutaneous Granulomatous Disease: a Unique Complication in Immune-Deficient Patients, Not Limited to DNA Repair Disorders.
Head and Neck Neoplasms
Involvement of single-nucleotide polymorphisms in predisposition to head and neck cancer in saudi arabia.
Head and Neck Neoplasms
The poly(ADP-Ribose) polymerase inhibitor ABT-888 reduces radiation-induced nuclear EGFR and augments head and neck tumor response to radiotherapy.
Head and Neck Neoplasms
[Report on the first year of the activity of the National Oncological RD Consortium]
Hepatitis C
Hepatitis C virus induces oxidative stress, DNA damage and modulates the DNA repair enzyme NEIL1.
Hepatitis C, Chronic
Insufficiency of DNA repair enzyme ATM promotes naive CD4 T-cell loss in chronic hepatitis C virus infection.
Hepatitis, Chronic
Differential expression of hepatic apurinic/apyrimidinic endonuclease 1, a DNA repair enzyme, in chronic hepatitis.
Herpes Simplex
Crystallization and preliminary X-ray analysis of the uracil-DNA glycosylase DNA repair enzyme from herpes simplex virus type 1.
Herpes Simplex
Isolation of a herpes simplex virus cDNA encoding the DNA repair enzyme uracil-DNA glycosylase.
Herpes Simplex
Knockdown of DNA ligase IV/XRCC4 by RNA interference inhibits herpes simplex virus type I DNA replication.
Herpes Simplex
Nucleotide sequence of a 55 kbp region from the right end of the genome of a pathogenic African swine fever virus isolate (Malawi LIL20/1).
Hip Dislocation
Failing to Make Ends Meet: The Broad Clinical Spectrum of DNA Ligase IV Deficiency. Case Series and Review of the Literature.
Hypersensitivity
Aberrant DNA repair and DNA replication due to an inherited enzymatic defect in human DNA ligase I.
Hypersensitivity
Arabidopsis DNA polymerase lambda mutant is mildly sensitive to DNA double strand breaks but defective in integration of a transgene.
Hypersensitivity
Concomitant reversion of the characteristic phenotypic properties of a cell line of Bloom's syndrome origin.
Hypersensitivity
DNA Ligase IV and Artemis Act Cooperatively to Suppress Homologous Recombination in Human Cells: Implications for DNA Double-Strand Break Repair.
Hypersensitivity
Four radiation hypersensitivity cases and their implications for clinical radiotherapy.
Hypersensitivity
Impact of carboplatin hypersensitivity and desensitization on patients with recurrent ovarian cancer.
Hypersensitivity
Inhibiting Mitochondrial DNA Ligase III? Activates Caspase 1-Dependent Apoptosis in Cancer Cells.
Hypersensitivity
Interaction between PCNA and DNA ligase I is critical for joining of Okazaki fragments and long-patch base-excision repair.
Hypersensitivity
Mutations in the DNA ligase I gene of an individual with immunodeficiencies and cellular hypersensitivity to DNA-damaging agents.
Hypersensitivity
Phenotypic correction of a human cell line (46BR) with aberrant DNA ligase I activity.
Hypersensitivity
The CHO XRCC1 mutant, EM9, deficient in DNA ligase III activity, exhibits hypersensitivity to camptothecin independent of DNA replication.
Infarction, Middle Cerebral Artery
Upregulation of mitochondrial base-excision repair capability within rat brain after brief ischemia.
Infections
A DNA ligase gene in the Copenhagen strain of vaccinia virus is nonessential for viral replication and recombination.
Infections
Attenuated measles virus overcomes radio? and chemoresistance in human breast cancer cells by inhibiting the non?homologous end joining pathway.
Infections
Caspase activation and specific cleavage of substrates after coxsackievirus B3-induced cytopathic effect in HeLa cells.
Infections
Characterization of cytotoxicity-related gene expression in response to virulent Marek's disease virus infection in the bursa of Fabricius.
Infections
Chemosensitizing effect of shRNA-mediated ERCC1 silencing on a Xuanwei lung adenocarcinoma cell line and its clinical significance.
Infections
Expression of the unassembled capsid protein during infection of Shigella sonnei by bacteriophage T7 results in DNA damage that is repairable by bacteriophage T3, but not T7, DNA ligase.
Infections
External Beam Radiation Therapy and Enadenotucirev: Inhibition of the DDR and Mechanisms of Radiation-Mediated Virus Increase.
Infections
Insufficiency of DNA repair enzyme ATM promotes naive CD4 T-cell loss in chronic hepatitis C virus infection.
Infections
Knockdown of DNA ligase IV/XRCC4 by RNA interference inhibits herpes simplex virus type I DNA replication.
Infections
Rescue of DNA replication and bacteriophage production after infection with T4 DNA ligase mutants.
Infections
Serotype-specific inactivation of the cellular DNA damage response during adenovirus infection.
Infections
Temporal changes in chromatin, intracellular calcium, and poly(ADP-ribose) polymerase during Sindbis virus-induced apoptosis of neuroblastoma cells.
Infections
The ?2 helix in the DNA ligase IV BRCT-1 domain is required for targeted degradation of ligase IV during adenovirus infection.
Infections
Vaccinia DNA ligase complements Saccharomyces cerevisiae cdc9, localizes in cytoplasmic factories and affects virulence and virus sensitivity to DNA damaging agents.
Infertility, Male
Inactivation of the HR6B ubiquitin-conjugating DNA repair enzyme in mice causes male sterility associated with chromatin modification.
Infertility, Male
Polymorphisms of DNA repair genes XRCC1 and LIG4 and idiopathic male infertility.
Inflammatory Bowel Diseases
Emerging views of mitophagy in immunity and autoimmune diseases.
Intellectual Disability
Failing to Make Ends Meet: The Broad Clinical Spectrum of DNA Ligase IV Deficiency. Case Series and Review of the Literature.
Ischemic Stroke
Circular RNA DLGAP4 Ameliorates Ischemic Stroke Outcomes by Targeting miR-143 to Regulate Endothelial-Mesenchymal Transition Associated with Blood-Brain Barrier Integrity.
Ischemic Stroke
Mitochondrial E3 ubiquitin ligase 1 promotes brain injury by disturbing mitochondrial dynamics in a rat model of ischemic stroke.
Ischemic Stroke
Polymorphism of PARP-1 indicates an increased risk and a worse initial severity of ischemic stroke.
Ischemic Stroke
The role of circular RNA HECTD1 expression in disease risk, disease severity, inflammation, and recurrence of acute ischemic stroke.
Keratosis, Actinic
DNA Repair Enzyme Containing Lip Balm for the Treatment of Actinic Cheilitis: A Pilot Study
Keratosis, Actinic
Reduced number of actinic keratoses with topical application of DNA repair enzyme creams.
Kidney Failure, Chronic
DNA repair XRCC1 Arg399Gln polymorphism is associated with the risk of development of end-stage renal disease.
Laryngeal Neoplasms
Small Nucleolar RNA Host Gene 12 (SNHG12) Promotes Proliferation and Invasion of Laryngeal Cancer Cells via Sponging miR-129-5p and Potentiating WW Domain-Containing E3 Ubiquitin Protein Ligase 1 (WWP1) Expression.
Leukemia
Benzamide potentiation of the cytotoxicity of bifunctional galactitol [correction of galacticol] in resistant P388 leukemia correlates with inhibition of DNA ligase II.
Leukemia
c-MYC Generates Repair Errors via Increased Transcription of Alternative-NHEJ Factors, LIG3 and PARP1, in Tyrosine Kinase-Activated Leukemias.
Leukemia
Cellular and biochemical impact of a mutation in DNA ligase IV conferring clinical radiosensitivity.
Leukemia
dATP-mediated inhibition of DNA ligase by 2'-deoxycoformycin in T and B cell leukemia.
Leukemia
Deregulation of mitochondrial sirtuins and OGG1-2a acts as a prognostic and diagnostic biomarker in leukemia.
Leukemia
DNA ligase I mRNA and enzyme levels in human hematopoietic cells under dimethyl sulfoxide-induced growth-arrest and differentiation.
Leukemia
DNA ligation in relation to DNA strand breaks in phytohemagglutinin-stimulated blast cells from acute lymphoblastic and nonlymphoblastic leukemia.
Leukemia
Phosphorylated Sp1 is the regulator of DNA-PKcs and DNA ligase IV transcription of daunorubicin-resistant leukemia cell lines.
Leukemia
Prognostic and clinical significance of long non-coding RNA SNHG12 expression in various cancers.
Leukemia
[Enzymes involved in the metabolism, replication and repair of DNA in acute leukemias (DNA ligases)]
Leukemia, B-Cell
dATP-mediated inhibition of DNA ligase by 2'-deoxycoformycin in T and B cell leukemia.
Leukemia, Erythroblastic, Acute
A possible effect of heme on the fate of DNA ligase activity extracted from differentiating mouse erythroleukemia cells.
Leukemia, Erythroblastic, Acute
DNA ligase and DNase activities in mouse erythroleukemia cells during dimethyl sulfoxide-induced differentiation.
Leukemia, Lymphocytic, Chronic, B-Cell
DNA repair enzyme expression in chronic lymphocytic leukemia vis-Ã -vis nitrogen mustard drug resistance.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Polymorphisms of ERCC1 genotype associated with response to imatinib therapy in chronic phase chronic myeloid leukemia.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Up-regulation of WRN and DNA ligase IIIalpha in chronic myeloid leukemia: consequences for the repair of DNA double-strand breaks.
Leukemia, Myeloid
Down-regulation of apurinic/apyrimidinic endonuclease expression is associated with the induction of apoptosis in differentiating myeloid leukemia cells.
Leukemia, Myeloid, Acute
DNA ligation in relation to DNA strand breaks in phytohemagglutinin-stimulated blast cells from acute lymphoblastic and nonlymphoblastic leukemia.
Leukemia, Myeloid, Acute
Effects of clinical combinations of antileukemic drugs on DNA ligase from human thymocytes and normal, stimulated, or leukemic lymphocytes.
Leukemia, Myeloid, Acute
O6-alkylguanine-DNA alkyltransferase attenuates triazene-induced cytotoxicity and tumor cell immunogenicity in murine L1210 leukemia.
Leukoplakia, Oral
Loss of expression of DNA repair enzyme MGMT in oral leukoplakia and early oral squamous cell carcinoma. A prognostic tool?
Liver Diseases
Oval cells compensate for damage and replicative senescence of mature hepatocytes in mice with fatty liver disease.
Liver Diseases
Oxidative DNA damage and DNA repair enzyme expression are inversely related in murine models of fatty liver disease.
Liver Neoplasms
Autophagy deficiency downregulates O6methylguanine-DNA methyltransferase and increases chemosensitivity of liver cancer cells.
Liver Neoplasms
Demethylation of the HACE1 gene promoter inhibits the proliferation of human liver cancer cells.
Lung Diseases
Small-Molecule Inhibitor of 8-Oxoguanine DNA Glycosylase 1 Regulates Inflammatory Responses during Pseudomonas aeruginosa Infection.
Lung Injury
DNA repair enzyme OGG1 promotes alveolar progenitor cell renewal and relieves PM2.5-induced lung injury and fibrosis.
Lung Injury
Mitochondrial Targeted Endonuclease III DNA Repair Enzyme Protects against Ventilator Induced Lung Injury in Mice.
Lung Neoplasms
A high-throughput screen identifies PARP1/2 inhibitors as a potential therapy for ERCC1-deficient non-small cell lung cancer.
Lung Neoplasms
A mammalian DNA repair enzyme that excises oxidatively damaged guanines maps to a locus frequently lost in lung cancer.
Lung Neoplasms
Association between O6-alkylguanine-DNA-alkyltransferase activity in peripheral blood lymphocytes and bronchial epithelial cells.
Lung Neoplasms
E3 ubiquitin ligase HECW1 promotes the metastasis of non-small cell lung cancer cells through mediating the ubiquitination of Smad4.
Lung Neoplasms
O6-Alkylguanine-DNA-alkyltransferase activity in peripheral leukocytes, smoking and risk of lung cancer.
Lung Neoplasms
Relationship between genetic polymorphisms of DNA ligase 1 and non-small cell lung cancer susceptibility and radiosensitivity.
Lung Neoplasms
Roles of DNA repair enzyme OGG1 in innate immunity and its significance for lung cancer.
Lung Neoplasms
Rs3212986 polymorphism, a possible biomarker to predict smoking-related lung cancer, alters DNA repair capacity via regulating ERCC1 expression.
Lung Neoplasms
The human 8-oxoguanine DNA N-glycosylase 1 (hOGG1) DNA repair enzyme and its association with lung cancer risk.
Lung Neoplasms
The oncogenic RNA-binding protein SRSF1 regulates LIG1 in non-small cell lung cancer.
Lupus Erythematosus, Systemic
Emerging views of mitophagy in immunity and autoimmune diseases.
Lymphatic Metastasis
Prognostic and clinical significance of long non-coding RNA SNHG12 expression in various cancers.
Lymphoma
A novel Ku70 function in colorectal homeostasis separate from nonhomologous end joining.
Lymphoma
Genetic variants of NHEJ DNA ligase IV can affect the risk of developing multiple myeloma, a tumour characterised by aberrant class switch recombination.
Lymphoma
Growth retardation and immunodeficiency in a patient with mutations in the DNA ligase I gene.
Lymphoma
O?-methylguanine-DNA methyltransferase promoter methylation in 45 primary central nervous system lymphomas: quantitative assessment of methylation and response to temozolomide treatment.
Lymphoma
Possible depletion of a DNA repair enzyme in human lymphoma cells by subversive repair.
Lymphoma, B-Cell
B-cell lymphoma 2 is associated with advanced tumor grade and clinical stage, and reduced overall survival in young Chinese patients with colorectal carcinoma.
Lymphoma, B-Cell
Epigenetic changes and their clinical relevance in Saudi diffuse large B-cell lymphoma. A molecular and tissue microarray analysis of 100 cases.
Lymphoma, B-Cell
Epstein-Barr virus-associated B-cell lymphoma in a patient with DNA ligase IV (LIG4) syndrome.
Lymphoma, B-Cell
Epstein-Barr virus-independent diffuse large B-cell lymphoma in DNA ligase 4 deficiency.
Lymphoma, B-Cell
Hypermethylation of the DNA repair gene O(6)-methylguanine DNA methyltransferase and survival of patients with diffuse large B-cell lymphoma.
Lymphoma, B-Cell
Next generation sequencing revealed DNA ligase IV deficiency in a "developmentally normal" patient with massive brain Epstein-Barr virus-positive diffuse large B-cell lymphoma.
Lymphoma, Large B-Cell, Diffuse
Epigenetic changes and their clinical relevance in Saudi diffuse large B-cell lymphoma. A molecular and tissue microarray analysis of 100 cases.
Lymphoma, Large B-Cell, Diffuse
Epstein-Barr virus-independent diffuse large B-cell lymphoma in DNA ligase 4 deficiency.
Lymphoma, Large B-Cell, Diffuse
Hypermethylation of the DNA repair gene O(6)-methylguanine DNA methyltransferase and survival of patients with diffuse large B-cell lymphoma.
Lymphoma, Large B-Cell, Diffuse
Next generation sequencing revealed DNA ligase IV deficiency in a "developmentally normal" patient with massive brain Epstein-Barr virus-positive diffuse large B-cell lymphoma.
Lymphoma, Non-Hodgkin
Response of DNA repair enzymes in murine fibrosarcoma, lymphosarcoma and ascites cells following gamma irradiation.
Lymphopenia
Application of a radiosensitivity flow assay in a patient with DNA ligase 4 deficiency.
Lymphopenia
Impact of temozolomide on immune response during malignant glioma chemotherapy.
Lymphoproliferative Disorders
Genetic variants of NHEJ DNA ligase IV can affect the risk of developing multiple myeloma, a tumour characterised by aberrant class switch recombination.
Malaria
Conditional knock-out of lipoic acid protein ligase 1 reveals redundancy pathway for lipoic acid metabolism in Plasmodium berghei malaria parasite.
Melanoma
A375 melanoma cells are sensitized to cisplatin-induced toxicity by a synthetic nitro-flavone derivative 2-(4-Nitrophenyl)-4H-chromen-4-one through inhibition of PARP1.
Melanoma
Apurinic/apyrimidinic endonuclease /redox effector factor-1(APE/Ref-1) a unique target for the prevention and treatment of human melanoma.
Melanoma
ERCC5 p.Asp1104His and ERCC2 p.Lys751Gln Polymorphisms Are Independent Prognostic Factors for the Clinical Course of Melanoma.
Melanoma
Eyes absent gene (EYA1) is a pathogenic driver and a therapeutic target for melanoma.
Melanoma
Genome-wide study on uveal melanoma patients finds association to DNA repair gene TDP1.
Melanoma
Modulation of chemotherapy resistance in regional therapy: a novel therapeutic approach to advanced extremity melanoma using intra-arterial temozolomide in combination with systemic O6-benzylguanine.
Melanoma
PARP1 inhibitor olaparib (Lynparza) exerts synthetic lethal effect against ligase 4-deficient melanomas.
Melanoma
The effect of O6-alkylguanine-DNA alkyltransferase and mismatch repair activities on the sensitivity of human melanoma cells to temozolomide, 1,3-bis(2-chloroethyl)1-nitrosourea, and cisplatin.
Melanoma
Treatment of human melanocytes and S91 melanoma cells with the DNA repair enzyme T4 endonuclease V enhances melanogenesis after ultraviolet irradiation.
Melanoma
Unbiased High-Throughput Drug Combination Pilot Screening Identifies Synergistic Drug Combinations Effective against Patient-Derived and Drug-Resistant Melanoma Cell Lines.
Meningitis, Bacterial
A putative role for homocysteine in the pathophysiology of acute bacterial meningitis in children.
Mesothelioma, Malignant
Asbestos increases mammalian AP-endonuclease gene expression, protein levels, and enzyme activity in mesothelial cells.
Microcephaly
A human iPSC model of Ligase IV deficiency reveals an important role for NHEJ-mediated-DSB repair in the survival and genomic stability of induced pluripotent stem cells and emerging haematopoietic progenitors.
Microcephaly
Failing to Make Ends Meet: The Broad Clinical Spectrum of DNA Ligase IV Deficiency. Case Series and Review of the Literature.
Microcephaly
Next generation sequencing revealed DNA ligase IV deficiency in a "developmentally normal" patient with massive brain Epstein-Barr virus-positive diffuse large B-cell lymphoma.
Microcephaly
Severe combined immunodeficiency and microcephaly in siblings with hypomorphic mutations in DNA ligase IV.
Mouth Neoplasms
Detection and Delineation of Oral Cancer With a PARP1-Targeted Optical Imaging Agent.
Mouth Neoplasms
High O6-methylguanine methyl transferase activity is frequently found in human oral cancer cells with p53 inactivation.
Mouth Neoplasms
Nonhomologous end joining repair pathway molecules as predictive biomarkers for patients with oral squamous cell carcinoma.
Multiple Myeloma
Clinicopathological and Immunohistochemical Profile of Mantle Cell Lymphoma: An Institutional Experience.
Multiple Myeloma
Genetic variants of NHEJ DNA ligase IV can affect the risk of developing multiple myeloma, a tumour characterised by aberrant class switch recombination.
Myocardial Infarction
DNA damage and repair in patients with coronary artery disease: Correlation with plaque morphology using optical coherence tomography (DECODE study).
Myocardial Infarction
Neil3-dependent base excision repair regulates lipid metabolism and prevents atherosclerosis in Apoe-deficient mice.
Myocardial Ischemia
Natural compound methyl protodioscin protects rat brain from ischemia/reperfusion injury through regulation of Mul1/SOD2 pathway.
Myotonic Dystrophy
CTG/CAG repeat instability is modulated by the levels of human DNA ligase i and its interaction with proliferating cell nuclear antigen: a distinction between replication and slipped-DNA repair.
Neoplasm Metastasis
Alteration of nuclear protein profiling for NIH-3T3 cells exposed to H?O?.
Neoplasm Metastasis
Prognostic and clinical significance of long non-coding RNA SNHG12 expression in various cancers.
Neoplasms
1HN, 13C, and 15N backbone resonance assignments of the human DNA ligase 3 DNA-binding domain (residues 257-477).
Neoplasms
A carboxy terminal domain of the hMSH-2 gene product is sufficient for binding specific mismatched oligonucleotides.
Neoplasms
A case-control study of the association of the polymorphisms and haplotypes of DNA ligase I with lung and upper-aerodigestive-tract cancers.
Neoplasms
A computational approach to determine susceptibility to cancer by evaluating the deleterious effect of nsSNP in XRCC1 gene on binding interaction of XRCC1 protein with ligase III.
Neoplasms
A Novel Benzocoumarin-Stilbene Hybrid as a DNA ligase I inhibitor with in vitro and in vivo anti-tumor activity in breast cancer models.
Neoplasms
A novel Ku70 function in colorectal homeostasis separate from nonhomologous end joining.
Neoplasms
A Novel Missense LIG4 Mutation in a Patient With a Phenotype Mimicking Behçet's Disease.
Neoplasms
A polyoma-induced hamster tumor cell with altered DNA synthesis in vivo and reduced polynucleotide ligase activity in vitro.
Neoplasms
Abnormal MGMT Promoter Methylation in Gastrointestinal Stromal Tumors: Genetic Susceptibility and Association with Clinical Outcome.
Neoplasms
Activity of O6-methylguanine DNA methyltransferase in mononuclear blood cells of formaldehyde-exposed medical students.
Neoplasms
Affinity purification and characterization of human O6-alkylguanine-DNA alkyltransferase complexed with BCNU-treated, synthetic oligonucleotide.
Neoplasms
Alkylation and Carbamylation Effects of Lomustine and Its Major Metabolites and MGMT Expression in Canine Cells.
Neoplasms
Allogeneic hematopoietic stem cell transplantation in two brothers with DNA ligase IV deficiency: a case report and review of the literature.
Neoplasms
Altered post-translational modification of redox factor 1 protein in human uterine smooth muscle tumors.
Neoplasms
An approach to the evaluation of the activity of the DNA repair enzyme O6-methylguanine-DNA-methyl-transferase in tumor tissue in vivo: syntheses of 6-benzyloxy-9-(2-[18F]fluoroethyl)-9H-purin-2-yl-amine and 6-benzyloxy-7-(2-[18F]fluoroethyl)-7H-purin-2-yl-amine.
Neoplasms
Association of Maximal Extent of Resection of Contrast-Enhanced and Non-Contrast-Enhanced Tumor With Survival Within Molecular Subgroups of Patients With Newly Diagnosed Glioblastoma.
Neoplasms
Association of polymorphisms in the cyclin D1 and XPD genes and susceptibility to cancers of the upper aero-digestive tract.
Neoplasms
B-cell lymphoma 2 is associated with advanced tumor grade and clinical stage, and reduced overall survival in young Chinese patients with colorectal carcinoma.
Neoplasms
Boosting 5-ALA-based photodynamic therapy by a liposomal nanomedicine through intracellular iron ion regulation.
Neoplasms
Cardiac myocyte apoptosis provokes adverse cardiac remodeling in transgenic mice with targeted TNF overexpression.
Neoplasms
Cargo-dependent mode of uptake and bioavailability of TAT-containing proteins and peptides in living cells.
Neoplasms
Characterization of a novel HHV-8-positive cell line reveals implications for the pathogenesis and cell cycle control of primary effusion lymphoma.
Neoplasms
Circular RNA hsa_circ_0000376 Participates in Tumorigenesis of Breast Cancer by Targeting miR-1285-3p.
Neoplasms
Clinicopathological and Immunohistochemical Profile of Mantle Cell Lymphoma: An Institutional Experience.
Neoplasms
Combined evaluation of Rad51 and ERCC1 expressions for sensitivity to platinum agents in non-small cell lung cancer.
Neoplasms
Could 8-oxoguanine DNA glycosylase 1 Ser326Cys polymorphism be a biomarker of susceptibility in cancer?
Neoplasms
CpG island hypermethylation of the DNA repair enzyme methyltransferase predicts response to temozolomide in primary gliomas.
Neoplasms
CsA can induce DNA double-strand breaks: implications for BMT regimens particularly for individuals with defective DNA repair.
Neoplasms
Curcumin Administered as Micellar Solution Suppresses Intestinal Inflammation and Colorectal Carcinogenesis.
Neoplasms
Demethylation of the HACE1 gene promoter inhibits the proliferation of human liver cancer cells.
Neoplasms
Developing a Peptide That Inhibits DNA Repair by Blocking the Binding of Artemis and DNA Ligase IV to Enhance Tumor Radiosensitivity.
Neoplasms
Distinct requirements of adenovirus E1b55K protein for degradation of cellular substrates.
Neoplasms
DNA ligase activity in human cell lines from normal donors and Bloom's syndrome patients.
Neoplasms
DNA ligase I is required for fetal liver erythropoiesis but is not essential for mammalian cell viability.
Neoplasms
Downregulation of Siah1 promotes colorectal cancer cell proliferation and migration by regulating AKT and YAP ubiquitylation and proteasome degradation.
Neoplasms
Elucidation of pharmacokinetics of novel DNA ligase I inhibitor, S012-1332 in rats: Integration of in vitro and in vivo findings.
Neoplasms
Enhanced repair of a cisplatin-damaged reporter chloramphenicol-O-acetyltransferase gene and altered activities of DNA polymerases alpha and beta, and DNA ligase in cells of a human malignant glioma following in vivo cisplatin therapy.
Neoplasms
Enhancing the cytotoxicity of chemoradiation with radiation-guided delivery of anti-MGMT morpholino oligonucleotides in non-methylated solid tumors.
Neoplasms
Epigenetic changes and their clinical relevance in Saudi diffuse large B-cell lymphoma. A molecular and tissue microarray analysis of 100 cases.
Neoplasms
Eukaryotic DNA ligase. Purification and properties of the enzyme from bovine thymus, and immunochemical studies of the enzyme from animal tissues.
Neoplasms
Evaluation of O6-methylguanine-DNA methyltransferase as a predicting factor of response to temozolomide-based chemotherapy in well-differentiated metastatic pancreatic neuroendocrine tumors.
Neoplasms
Expression of DNA repair enzyme hMTH1 mRNA and protein in hepatocellular carcinoma.
Neoplasms
Expression of O6-methylguanine-deoxyribose nucleic acid methyltransferase and temozolomide response in a patient with a malignant spinal cord astrocytoma. Case report.
Neoplasms
Expression of O6-methylguanine-DNA methyltransferase in malignant human glioma cell lines.
Neoplasms
Expression of the DNA repair enzyme, N-methylpurine-DNA glycosylase (MPG) in astrocytic tumors.
Neoplasms
Failing to Make Ends Meet: The Broad Clinical Spectrum of DNA Ligase IV Deficiency. Case Series and Review of the Literature.
Neoplasms
Fluorescence Probes for ALKBH2 Allow the Measurement of DNA Alkylation Repair and Drug Resistance Responses.
Neoplasms
Formation of benzo[a]pyrene diol epoxide-DNA adducts at specific guanines within K-ras and p53 gene sequences: stable isotope-labeling mass spectrometry approach.
Neoplasms
Gene amplification and expression of the DNA repair enzyme, N-methylpurine-DNA glycosylase (MPG) in HPV-infected cervical neoplasias.
Neoplasms
Genetic variants of NHEJ DNA ligase IV can affect the risk of developing multiple myeloma, a tumour characterised by aberrant class switch recombination.
Neoplasms
Genistein-induced changes in gene expression in Panc 1 cells at physiological concentrations of genistein.
Neoplasms
Graphene Quantum Dot-Based Nanocomposites for Diagnosing Cancer Biomarker APE1 in Living Cells.
Neoplasms
HACE1 is a putative tumor suppressor gene in B-cell lymphomagenesis and is down-regulated by both deletion and epigenetic alterations.
Neoplasms
HACE1 reduces oxidative stress and mutant Huntingtin toxicity by promoting the NRF2 response.
Neoplasms
Histone chaperone FACT complex inhibitor CBL0137 interferes with DNA damage repair and enhances sensitivity of medulloblastoma to chemotherapy and radiation.
Neoplasms
Human DNA ligase III bridges two DNA ends to promote specific intermolecular DNA end joining.
Neoplasms
Human O(6)-alkylguanine-DNA alkyltransferase: protection against alkylating agents and sensitization to dibromoalkanes.
Neoplasms
Hypermethylation of the DNA repair gene O(6)-methylguanine DNA methyltransferase and survival of patients with diffuse large B-cell lymphoma.
Neoplasms
Identification of key genes associated with congenital heart defects in embryos of diabetic mice.
Neoplasms
Identification of novel heterozygous Apex 1 gene variant (Glu87Gln) in patients with head and neck cancer of Indian origin.
Neoplasms
Identification of probe-quality degraders for Poly(ADP-ribose) polymerase-1 (PARP-1).
Neoplasms
Impaired lymphocyte development and antibody class switching and increased malignancy in a murine model of DNA ligase IV syndrome.
Neoplasms
Importance of the DNA repair enzyme O6-alkyl guanine alkyltransferase (AT) in cancer chemotherapy.
Neoplasms
In vitro methylation of the human O6-methylguanine-DNA methyltransferase promoter reduces transcription.
Neoplasms
Induction of the DNA repair gene O6-methylguanine-DNA methyltransferase by dexamethasone in glioblastomas.
Neoplasms
Inhibiting Mitochondrial DNA Ligase III? Activates Caspase 1-Dependent Apoptosis in Cancer Cells.
Neoplasms
Inhibition of O6-alkylguanine DNA-alkyltransferase or poly(ADP-ribose) polymerase increases susceptibility of leukemic cells to apoptosis induced by temozolomide.
Neoplasms
Knockdown of WWP1 inhibits growth and induces apoptosis in hepatoma carcinoma cells through the activation of caspase3 and p53.
Neoplasms
Knockdown of WWP1 inhibits growth and invasion, but induces apoptosis of osteosarcoma cells.
Neoplasms
Lack of associations between LIG3 gene polymorphisms and neuroblastoma susceptibility in Chinese children.
Neoplasms
Levels of the DNA repair enzyme human apurinic/apyrimidinic endonuclease (APE1, APEX, Ref-1) are associated with the intrinsic radiosensitivity of cervical cancers.
Neoplasms
LIG3 gene polymorphisms and risk of gastric cancer in a Southern Chinese population.
Neoplasms
Ligase IV inhibitor SCR7 enhances gene editing directed by CRISPR-Cas9 and ssODN in human cancer cells.
Neoplasms
LUBAC and OTULIN regulate autophagy initiation and maturation by mediating the linear ubiquitination and the stabilization of ATG13.
Neoplasms
Mammalian APE1 controls miRNA processing and its interactome is linked to cancer RNA metabolism.
Neoplasms
Mechanisms of genome maintenance and rearrangement: current research and recent advances in DNA repair and recombination.
Neoplasms
Modeling of the Enzyme-Substrate Complexes of Human Poly(ADP-Ribose) Polymerase 1.
Neoplasms
Modulation of O6-alkylguanine alkyltransferase-directed DNA repair in metastatic colon cancers.
Neoplasms
N-methylpurine DNA glycosylase inhibits p53-mediated cell cycle arrest and coordinates with p53 to determine sensitivity to alkylating agents.
Neoplasms
Non-homologous end joining, but not homologous recombination, enables survival for cells exposed to a histone deacetylase inhibitor.
Neoplasms
Nonhomologous end joining repair pathway molecules as predictive biomarkers for patients with oral squamous cell carcinoma.
Neoplasms
Novel Inhibitors of DNA Repair Enzyme TDP1 Combining Monoterpenoid and Adamantane Fragments.
Neoplasms
Novel mechanism of regulation of the DNA repair enzyme OGG1 in tuberin-deficient cells.
Neoplasms
Novel somatic mutations identified by whole-exome sequencing in muscle-invasive transitional cell carcinoma of the bladder.
Neoplasms
Nucleotide sequence of 42 kbp of vaccinia virus strain WR from near the right inverted terminal repeat.
Neoplasms
O6-alkylguanine-DNA alkyltransferase activity in epidermal tumor and normal epidermal cells of mice of various stocks and strains.
Neoplasms
O6-methylguanine DNA methyltransferase and p53 status predict temozolomide sensitivity in human malignant glioma cells.
Neoplasms
O6-methylguanine DNA methyltransferase as a promising target for the treatment of temozolomide-resistant gliomas.
Neoplasms
O6-methylguanine DNA methyltransferase deficiency and response to temozolomide-based therapy in patients with neuroendocrine tumors.
Neoplasms
O?-methylguanine-DNA methyltransferase promoter methylation in 45 primary central nervous system lymphomas: quantitative assessment of methylation and response to temozolomide treatment.
Neoplasms
Oncolytic adenovirus-expressed RNA interference of O(6)-methylguanine DNA methyltransferase activity may enhance the antitumor effects of temozolomide.
Neoplasms
Overexpression of WWP1 promotes tumorigenesis and predicts unfavorable prognosis in patients with hepatocellular carcinoma.
Neoplasms
Oxidative Stress and DNA Damage in Human Gastric Carcinoma: 8-Oxo-7'8-dihydro-2'-deoxyguanosine (8-oxo-dG) as a Possible Tumor Marker.
Neoplasms
p53 mutations, O6-alkylguanine DNA alkyltransferase activity, and sensitivity to procarbazine in human brain tumors.
Neoplasms
Pharmacokinetics of temozolomide in association with fotemustine in malignant melanoma and malignant glioma patients: comparison of oral, intravenous, and hepatic intra-arterial administration.
Neoplasms
Polynucleotide ligase from kidney tumors in rats induced by N-nitrosodimethylamine.
Neoplasms
Predictive value of epithelial-mesenchymal-transition (EMT) signature and PARP-1 in prostate cancer radioresistance.
Neoplasms
Problem-solving test: analysis of DNA damage recognizing proteins in yeast and human cells.
Neoplasms
Prognostic and clinical significance of long non-coding RNA SNHG12 expression in various cancers.
Neoplasms
Promoter CpG Island Hypermethylation of the DNA Repair Enzyme MGMT Predicts Clinical Response to Dacarbazine in a Phase II Study for Metastatic Colorectal Cancer.
Neoplasms
Radiation-hypersensitive cancer patients do not manifest protein expression abnormalities in components of the nonhomologous end-joining (NHEJ) pathway.
Neoplasms
Recent advances in the targeting of human DNA ligase I as a potential new strategy for cancer treatment.
Neoplasms
Recent development in the discovery of PARP inhibitors as anticancer agents: a patent update (2016-2020).
Neoplasms
Reconstitution of complete SV40 DNA replication with purified replication factors.
Neoplasms
Replication failure, genome instability, and increased cancer susceptibility in mice with a point mutation in the DNA ligase I gene.
Neoplasms
Robustadial A and B from Eucalyptus globulus Labill. and their anticancer activity as selective tyrosyl-DNA phosphodiesterase 2 inhibitors.
Neoplasms
Role of a BRCT domain in the interaction of DNA ligase III-alpha with the DNA repair protein XRCC1.
Neoplasms
Rs3212986 polymorphism, a possible biomarker to predict smoking-related lung cancer, alters DNA repair capacity via regulating ERCC1 expression.
Neoplasms
Sensitive and specific microRNA detection by RNA dependent DNA ligation and rolling circle optical signal amplification.
Neoplasms
Serous ovarian tumors: Immunohistochemical profiling as an aid to grading and understanding tumorigenesis.
Neoplasms
Simple synthesis of carbon-11-labeled chromen-4-one derivatives as new potential PET agents for imaging of DNA-dependent protein kinase (DNA-PK) in cancer.
Neoplasms
Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase.
Neoplasms
Strategies to Improve the Killing of Tumors Using Temozolomide: Targeting the DNA Repair Protein MGMT.
Neoplasms
Synthesis and bio-evaluation of indole-chalcone based benzopyrans as promising antiligase and antiproliferative agents.
Neoplasms
Synthesis of 131I-labeled glucose-conjugated inhibitors of O6-methylguanine-DNA methyltransferase (MGMT) and comparison with nonconjugated inhibitors as potential tools for in vivo MGMT imaging.
Neoplasms
Targeting DNA repair with combination veliparib (ABT-888) and temozolomide in patients with metastatic castration-resistant prostate cancer.
Neoplasms
Temozolomide analog PMX 465 downregulates MGMT expression in HCT116 colorectal carcinoma cells.
Neoplasms
The clinically active PARP inhibitor AG014699 ameliorates cardiotoxicity but does not enhance the efficacy of doxorubicin, despite improving tumor perfusion and radiation response in mice.
Neoplasms
The HIV reverse transcriptase inhibitor tenofovir induces cell cycle arrest in human cancer cells.
Neoplasms
The human OGG1 DNA repair enzyme and its association with orolaryngeal cancer risk.
Neoplasms
The N-terminal domain of the non-receptor tyrosine kinase ABL confers protein instability and suppresses tumorigenesis.
Neoplasms
The WW domain containing E3 ubiquitin protein ligase 1 upregulates ErbB2 and EGFR through RING finger protein 11.
Neoplasms
Thin layer chromatography-based assay of O6-methylguanine-DNA methyltransferase activity in tissue.
Neoplasms
Thyroid carcinomas that express telomerase follow a more aggressive clinical course in children and adolescents.
Neoplasms
Transcript signatures that predict outcome and identify targetable pathways in MYCN-amplified neuroblastoma.
Neoplasms
Treatment options for malignant gliomas, emphasizing towards new molecularly targeted therapies.
Neoplasms
Validation of the use of a fluorescent PARP1 inhibitor for the detection of oral, oropharyngeal and oesophageal epithelial cancers.
Neoplasms
Wnt/?-catenin pathway regulates MGMT gene expression in cancer and inhibition of Wnt signalling prevents chemoresistance.
Neoplasms
WW domain-containing E3 ubiquitin protein ligase 1 depletion evokes antitumor effect in cutaneous squamous cell carcinoma by inhibiting signal transducer and activator of transcription 3 signaling pathway.
Neoplasms
WWP1 as a potential tumor oncogene regulates PTEN-Akt signaling pathway in human gastric carcinoma.
Neoplasms
WWP1 delays cellular senescence by promoting p27Kip1 degradation in human diploid fibroblasts.
Neoplasms, Second Primary
DNA repair gene polymorphisms and risk of second primary neoplasms and mortality in oral cancer patients.
Nervous System Diseases
Molecular underpinnings of Aprataxin RNA/DNA deadenylase function and dysfunction in neurological disease.
Neural Tube Defects
MGMT is down-regulated independently of promoter DNA methylation in rats with all-trans retinoic acid-induced spina bifida aperta.
Neuroblastoma
Alternative NHEJ Pathway Components Are Therapeutic Targets in High-Risk Neuroblastoma.
Neuroblastoma
Alternative NHEJ pathway proteins as components of MYCN oncogenic activity in human neural crest stem cell differentiation: implications for neuroblastoma initiation.
Neuroblastoma
Cooperation of the HDAC inhibitor vorinostat and radiation in metastatic neuroblastoma: efficacy and underlying mechanisms.
Neuroblastoma
IFN-beta sensitizes neuroblastoma to the antitumor activity of temozolomide by modulating O6-methylguanine DNA methyltransferase expression.
Neurodegenerative Diseases
8-Oxoguanine DNA glycosylase modulates the cell transformation process in pulmonary fibrosis by inhibiting Smad2/3 and interacting with Smad7.
Neurodegenerative Diseases
Bayesian Cox Proportional Hazards Model in Survival Analysis of HACE1 Gene with Age at Onset of Alzheimer's Disease.
Neurodegenerative Diseases
Nicotinamide, a Poly [ADP-Ribose] Polymerase 1 (PARP-1) Inhibitor, as an Adjunctive Therapy for the Treatment of Alzheimer's Disease.
Neuroendocrine Tumors
Clinical and in vitro studies of the correlation between MGMT and the effect of streptozocin in pancreatic NET.
Neuroendocrine Tumors
DNA repair enzyme expression and differential response to temozolomide in a patient with both glioblastoma and metastatic pancreatic neuroendocrine tumor.
Neuroinflammatory Diseases
Involvement of HECTD1 in LPS-induced astrocyte activation via ?-1R-JNK/p38-FOXJ2 axis.
Nijmegen Breakage Syndrome
A patient with mutations in DNA Ligase IV: clinical features and overlap with Nijmegen breakage syndrome.
Nijmegen Breakage Syndrome
Accelerated telomere shortening and telomere abnormalities in radiosensitive cell lines.
Nijmegen Breakage Syndrome
Clinical variability and novel mutations in the NHEJ1 gene in patients with a Nijmegen breakage syndrome-like phenotype.
Nijmegen Breakage Syndrome
DNA Repair Syndromes and Cancer: Insights Into Genetics and Phenotype Patterns.
Nijmegen Breakage Syndrome
Identification of proteins in the hamster DNA end-binding complex.
Nijmegen Breakage Syndrome
Indicators of late normal tissue response after radiotherapy for head and neck cancer: fibroblasts, lymphocytes, genetics, DNA repair, and chromosome aberrations.
Nijmegen Breakage Syndrome
Outcome of hematopoietic cell transplantation for DNA double-strand break repair disorders.
Nijmegen Breakage Syndrome
Rubella Virus-Associated Cutaneous Granulomatous Disease: a Unique Complication in Immune-Deficient Patients, Not Limited to DNA Repair Disorders.
Non-alcoholic Fatty Liver Disease
Beneficial effects of neomangiferin on high fat diet-induced nonalcoholic fatty liver disease in rats.
non-specific serine/threonine protein kinase deficiency
Update on DNA-Double Strand Break Repair Defects in Combined Primary Immunodeficiency.
Non-ST Elevated Myocardial Infarction
DNA damage and repair in patients with coronary artery disease: Correlation with plaque morphology using optical coherence tomography (DECODE study).
Oligodendroglioma
Enhanced repair of a cisplatin-damaged reporter chloramphenicol-O-acetyltransferase gene and altered activities of DNA polymerases alpha and beta, and DNA ligase in cells of a human malignant glioma following in vivo cisplatin therapy.
Oligodendroglioma
Frequent promoter hypermethylation and low expression of the MGMT gene in oligodendroglial tumors.
Osteoarthritis
The DNA repair enzyme apurinic/apyrimidinic endonuclease (Apex nuclease) 2 has the potential to protect against down-regulation of chondrocyte activity in osteoarthritis.
Osteosarcoma
E2F-1 and a cyclin-like DNA repair enzyme, uracil-DNA glycosylase, provide evidence for an autoregulatory mechanism for transcription.
Ovarian Neoplasms
MicroRNA-497 inhibition of ovarian cancer cell migration and invasion through targeting of SMAD specific E3 ubiquitin protein ligase 1.
Ovarian Neoplasms
Nanoparticle-mediated delivery of siRNA targeting Parp1 extends survival of mice bearing tumors derived from Brca1-deficient ovarian cancer cells.
Pancreatic Neoplasms
Induction of DNA ligase I by 1-beta-D-arabinosylcytosine and aphidicolin in MiaPaCa human pancreatic cancer cells.
Papillomavirus Infections
Expression of Inflammasome-Associated Proteins in Human Oropharyngeal Squamous Cell Carcinoma.
Paramyxoviridae Infections
Emerging views of mitophagy in immunity and autoimmune diseases.
Parkinson Disease
Organelle-specific autophagy in inflammatory diseases: a potential therapeutic target underlying the quality control of multiple organelles.
Parkinson Disease
Up-regulation of hMUTYH, a DNA repair enzyme, in the mitochondria of substantia nigra in Parkinson's disease.
Pituitary Neoplasms
Recent clinical and pathophysiological advances in non-functioning pituitary adenomas.
Pituitary Neoplasms
Tanshinone IIA induces apoptosis via inhibition of Wnt/??catenin/MGMT signaling in AtT?20 cells.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
DNA ligation in relation to DNA strand breaks in phytohemagglutinin-stimulated blast cells from acute lymphoblastic and nonlymphoblastic leukemia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Fingerprinting of near-homogeneous DNA ligase I and II from human cells. Similarity of their AMP-binding domains.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Polymorphisms in the DNA ligase IV gene might influence the risk of acute lymphoblastic leukemia in children.
Primary Immunodeficiency Diseases
Molecular and immunological characterization of DNA ligase IV deficiency.
Prostatic Neoplasms
Co-administration of genistein with doxorubicin-loaded polypeptide nanoparticles weakens the metastasis of malignant prostate cancer by amplifying oxidative damage.
Prostatic Neoplasms
Design and Synthesis of a Trifunctional Molecular System "Programmed" to Block Epidermal Growth Factor Receptor Tyrosine Kinase, Induce High Levels of DNA Damage, and Inhibit the DNA Repair Enzyme (Poly(ADP-ribose) Polymerase) in Prostate Cancer Cells.
Prostatic Neoplasms
Expression of DNA ligase IV is linked to poor prognosis and characterizes a subset of prostate cancers harboring TMPRSS2:ERG fusion and PTEN deletion.
Prostatic Neoplasms
Genomic analysis of DNA repair genes and androgen signaling in prostate cancer.
Pulmonary Disease, Chronic Obstructive
Organelle-specific autophagy in inflammatory diseases: a potential therapeutic target underlying the quality control of multiple organelles.
Pulmonary Disease, Chronic Obstructive
Prognostic and clinical significance of long non-coding RNA SNHG12 expression in various cancers.
Radiation Pneumonitis
Genetic variants of the nonhomologous end joining gene LIG4 and severe radiation pneumonitis in nonsmall cell lung cancer patients treated with definitive radiotherapy.
Retinoblastoma
UHRF1 depletion sensitizes retinoblastoma cells to chemotherapeutic drugs via downregulation of XRCC4.
Rubella
DNA Ligase IV Deficiency Identified by Chance Following Vaccine-Derived Rubella Virus Infection.
Sarcoma
Prognostic and clinical significance of long non-coding RNA SNHG12 expression in various cancers.
Sarcoma, Ewing
Characteristic increase in nucleocytoplasmic protein glycosylation by O-GlcNAc in 3T3-L1 adipocyte differentiation.
Sepsis
Staphylococcus Aureus Sepsis and Mitochondrial Accrual of OGG1 DNA Repair Enzyme in Mice.
Severe Combined Immunodeficiency
A new gene involved in DNA double-strand break repair and V(D)J recombination is located on human chromosome 10p.
Severe Combined Immunodeficiency
Allogeneic hematopoietic stem cell transplantation in two brothers with DNA ligase IV deficiency: a case report and review of the literature.
Severe Combined Immunodeficiency
Failing to Make Ends Meet: The Broad Clinical Spectrum of DNA Ligase IV Deficiency. Case Series and Review of the Literature.
Severe Combined Immunodeficiency
Omenn syndrome is associated with mutations in DNA ligase IV.
Severe Combined Immunodeficiency
Severe combined immunodeficiency and microcephaly in siblings with hypomorphic mutations in DNA ligase IV.
Skin Neoplasms
DNA Repair Enzyme Containing Lip Balm for the Treatment of Actinic Cheilitis: A Pilot Study
Skin Neoplasms
Preventive Long-Term Effects of a Topical Film-Forming Medical Device with Ultra-High UV Protection Filters and DNA Repair Enzyme in Xeroderma Pigmentosum: A Retrospective Study of Eight Cases.
Skin Neoplasms
Reduced ultraviolet-induced DNA damage and apoptosis in human skin with topical application of a photolyase-containing DNA repair enzyme cream: clues to skin cancer prevention.
Smallpox
Nucleotide sequence of 21.8 kbp of variola major virus strain Harvey and comparison with vaccinia virus.
Smooth Muscle Tumor
Altered post-translational modification of redox factor 1 protein in human uterine smooth muscle tumors.
Spinocerebellar Ataxias
Identification of novel inhibitors for the tyrosyl-DNA-phosphodiesterase 1 (Tdp1) mutant SCAN1 using virtual screening.
Squamous Cell Carcinoma of Head and Neck
Absence of MGMT promoter methylation in endometrial cancer.
Squamous Cell Carcinoma of Head and Neck
Loss of expression of DNA repair enzyme MGMT in oral leukoplakia and early oral squamous cell carcinoma. A prognostic tool?
Squamous Cell Carcinoma of Head and Neck
Nonhomologous end joining repair pathway molecules as predictive biomarkers for patients with oral squamous cell carcinoma.
steroid 21-monooxygenase deficiency
Detection of steroid 21-hydroxylase alleles using gene-specific PCR and a multiplexed ligation detection reaction.
Stomach Neoplasms
Biomarkers of individual susceptibility to carcinogens: application for biological monitoring.
Stomach Neoplasms
Higher Expression of ERCC1 May Be Associated with Resistance to Adjuvant Platinum-Based Chemotherapy in Gastric Cancer.
Stomach Neoplasms
Loss of expression of DNA repair enzymes MGMT, hMLH1, and hMSH2 during tumor progression in gastric cancer.
Stomach Neoplasms
Overexpression of miR-584-5p inhibits proliferation and induces apoptosis by targeting WW domain-containing E3 ubiquitin protein ligase 1 in gastric cancer.
Stroke
Circular RNA DLGAP4 Ameliorates Ischemic Stroke Outcomes by Targeting miR-143 to Regulate Endothelial-Mesenchymal Transition Associated with Blood-Brain Barrier Integrity.
Telangiectasis
Mechanisms of genome maintenance and rearrangement: current research and recent advances in DNA repair and recombination.
Triple Negative Breast Neoplasms
DNA Ligase IV Prevents Replication Fork Stalling and Promotes Cellular Proliferation in Triple Negative Breast Cancer.
Tuberculosis
Characterization of the roles of the catalytic domains of Mycobacterium tuberculosis ligase D in Ku-dependent error-prone DNA end joining.
Tuberculosis
Expression of Mycobacterium tuberculosis Ku and Ligase D in Escherichia coli results in RecA and RecB-independent DNA end-joining at regions of microhomology.
Tuberculosis
Mycobacteria exploit three genetically distinct DNA double-strand break repair pathways.
Tuberculosis
Mycobacterial Ku and ligase proteins constitute a two-component NHEJ repair machine.
Tuberculosis
Mycobacterium tuberculosis and Mycobacterium marinum non-homologous end-joining proteins can function together to join DNA ends in Escherichia coli.
Tuberculosis
Mycobacterium tuberculosis NAD+-dependent DNA ligase is selectively inhibited by glycosylamines compared with human DNA ligase I.
Tuberculosis
Naphthalimides Selectively Inhibit the Activity of Bacterial, Replicative DNA Ligases and Display Bactericidal Effects against Tubercle Bacilli.
Tuberculosis
Pathways for double-strand break repair in genetically unstable Z-DNA-forming sequences.
Tuberculosis
Structures of ATP-bound DNA ligase D in a closed domain conformation reveal a network of amino acid and metal contacts to the ATP phosphates.
Tuberculosis
The phage T4 DNA ligase mediates bacterial chromosome DSBs repair as single component non-homologous end joining.
Tuberculosis
Toward the virtual screening of potential drugs in the homology modeled NAD+ dependent DNA ligase from Mycobacterium tuberculosis.
Tuberculosis
Tricyclic dihydrobenzoxazepine and tetracyclic indole derivatives can specifically target bacterial DNA ligases and can distinguish them from human DNA ligase I.
Tuberous Sclerosis
Novel mechanism of regulation of the DNA repair enzyme OGG1 in tuberin-deficient cells.
Uterine Cervical Neoplasms
Human DNA ligase i (ligi) gene and risk of cervical cancer in North Indian women.
Uterine Cervical Neoplasms
The apurinic/apyrimidinic endonuclease (APE/ref-1) DNA repair enzyme is elevated in premalignant and malignant cervical cancer.
Vaccinia
A DNA ligase gene in the Copenhagen strain of vaccinia virus is nonessential for viral replication and recombination.
Vaccinia
An etoposide-induced block in vaccinia virus telomere resolution is dependent on the virus-encoded DNA ligase.
Vaccinia
Cellular DNA ligase I is recruited to cytoplasmic vaccinia virus factories and masks the role of the vaccinia ligase in viral DNA replication.
Vaccinia
Construction of a vaccinia virus deficient in the essential DNA repair enzyme uracil DNA glycosylase by a complementing cell line.
Vaccinia
Deletion of fowlpox virus homologues of vaccinia virus genes between the 3 beta-hydroxysteroid dehydrogenase (A44L) and DNA ligase (A50R) genes.
Vaccinia
DNA ligase gene disruptions can depress viral growth and replication in poxvirus-infected cells.
Vaccinia
Identification of novel antipoxviral agents: mitoxantrone inhibits vaccinia virus replication by blocking virion assembly.
Vaccinia
Intercalating polycyclic aromatic hydrocarbon-DNA adducts poison DNA religation by Vaccinia topoisomerase and act as roadblocks to digestion by exonuclease III.
Vaccinia
Ligation of double-stranded and single-stranded [oligo(dT)] DNA by vaccinia virus DNA ligase.
Vaccinia
Mammalian DNA ligase II is highly homologous with vaccinia DNA ligase. Identification of the DNA ligase II active site for enzyme-adenylate formation.
Vaccinia
Molecular characterisation of a DNA ligase gene of the extremely thermophilic archaeon Desulfurolobus ambivalens shows close phylogenetic relationship to eukaryotic ligases.
Vaccinia
Mutagenic repair of double-stranded DNA breaks in vaccinia virus genomes requires cellular DNA ligase IV activity in the cytosol.
Vaccinia
Mutational analysis of vaccinia DNA ligase defines residues essential for covalent catalysis.
Vaccinia
Nick sensing by vaccinia virus DNA ligase requires a 5' phosphate at the nick and occupancy of the adenylate binding site on the enzyme.
Vaccinia
Nucleotide sequence of 21.8 kbp of variola major virus strain Harvey and comparison with vaccinia virus.
Vaccinia
Polynucleotide ligase activity in cells infected with simian virus 40, polyoma virus, or vaccinia virus.
Vaccinia
Purification and characterization of DNA ligase I from the trypanosomatid Crithidia fasciculata.
Vaccinia
Purification and characterization of DNA ligase III from bovine testes. Homology with DNA ligase II and vaccinia DNA ligase.
Vaccinia
Reduced DNA ligase activity in etoposide resistant human lymphatic leukaemia CEM cells.
Vaccinia
Transcriptional mapping and nucleotide sequence of a vaccinia virus gene encoding a polypeptide with extensive homology to DNA ligases.
Vaccinia
Vaccinia DNA ligase complements Saccharomyces cerevisiae cdc9, localizes in cytoplasmic factories and affects virulence and virus sensitivity to DNA damaging agents.
Vaccinia
Vaccinia virus DNA ligase is nonessential for virus replication: recovery of plasmids from virus-infected cells.
Vaccinia
Vaccinia virus DNA ligase recruits cellular topoisomerase II to sites of viral replication and assembly.
Ventilator-Induced Lung Injury
Mitochondrial Targeted Endonuclease III DNA Repair Enzyme Protects against Ventilator Induced Lung Injury in Mice.
Ventilator-Induced Lung Injury
Mitochondrial-targeted DNA repair enzyme 8-oxoguanine DNA glycosylase 1 protects against ventilator-induced lung injury in intact mice.
Virus Diseases
DNA Ligase IV Deficiency Identified by Chance Following Vaccine-Derived Rubella Virus Infection.
Virus Diseases
Insufficiency of DNA repair enzyme ATM promotes naive CD4 T-cell loss in chronic hepatitis C virus infection.
Werner Syndrome
Up-regulation of WRN and DNA ligase IIIalpha in chronic myeloid leukemia: consequences for the repair of DNA double-strand breaks.
Wilms Tumor
Serous ovarian tumors: Immunohistochemical profiling as an aid to grading and understanding tumorigenesis.
Wiskott-Aldrich Syndrome
Newborn screening using TREC/KREC assay for severe T and B cell lymphopenia in Iran.
Xeroderma Pigmentosum
Accelerated telomere shortening and telomere abnormalities in radiosensitive cell lines.
Xeroderma Pigmentosum
Dietary berries and ellagic Acid prevent oxidative DNA damage and modulate expression of DNA repair genes.
Xeroderma Pigmentosum
DNA Repair Syndromes and Cancer: Insights Into Genetics and Phenotype Patterns.
Xeroderma Pigmentosum
DNA repair XRCC1 Arg399Gln polymorphism is associated with the risk of development of end-stage renal disease.
Xeroderma Pigmentosum
Enhanced DNA repair of cyclobutane pyrimidine dimers changes the biological response to UV-B radiation.
Xeroderma Pigmentosum
Enhanced unscheduled DNA synthesis in UV-irradiated human skin explants treated with T4N5 liposomes.
Xeroderma Pigmentosum
Enhancement of ultraviolet-DNA repair in denV gene transfectants and T4 endonuclease V-liposome recipients.
Xeroderma Pigmentosum
Enzyme therapy of xeroderma pigmentosum: safety and efficacy testing of T4N5 liposome lotion containing a prokaryotic DNA repair enzyme.
Xeroderma Pigmentosum
Four radiation hypersensitivity cases and their implications for clinical radiotherapy.
Xeroderma Pigmentosum
Genesis of the strand-biased signature in somatic hypermutation of rearranged immunoglobulin variable genes.
Xeroderma Pigmentosum
Imiquimod-Induced TLR7 Signaling Enhances Repair of DNA Damage Induced by Ultraviolet Light in Bone Marrow-Derived Cells.
Xeroderma Pigmentosum
Mechanisms of genome maintenance and rearrangement: current research and recent advances in DNA repair and recombination.
Xeroderma Pigmentosum
Poly(ADP-ribose) binds to specific domains in DNA damage checkpoint proteins.
Xeroderma Pigmentosum
Polymorphisms of DNA repair genes XPD and XRCC1 and risk of cataract development.
Xeroderma Pigmentosum
Polymorphisms of DNA repair genes XRCC1 and XPD and risk of primary open angle glaucoma (POAG).
Xeroderma Pigmentosum
Polymorphisms of the DNA repair genes XPD and XRCC1 and the risk of age-related cataract development in Han Chinese.
Xeroderma Pigmentosum
Polymorphisms of the DNA repair genes XPD and XRCC1 and the risk of age-related macular degeneration.
Xeroderma Pigmentosum
Preventive Long-Term Effects of a Topical Film-Forming Medical Device with Ultra-High UV Protection Filters and DNA Repair Enzyme in Xeroderma Pigmentosum: A Retrospective Study of Eight Cases.
Xeroderma Pigmentosum
The role of protein binding of trivalent arsenicals in arsenic carcinogenesis and toxicity.
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pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable).
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable). Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
CDELTA1
Paramecium bursaria chlorella virus
mutant with deleted C-terminal five amino acids: mutant shows 34% the specific activity of wild-type. Preformed Lig-AMP in vivo: 71% of total enzyme (wild-type: 70%), preformed Lig-AMP in vitro: 8% of total enzyme (wild-type: 21%)
CDELTA2
Paramecium bursaria chlorella virus
mutant with deleted C-terminal five amino acids: mutant shows 6% the specific activity of wild-type. Preformed Lig-AMP in vivo: 80% of total enzyme (wild-type: 70%), preformed Lig-AMP in vitro: 1.1% of total enzyme (wild-type: 21%)
CDELTA3
Paramecium bursaria chlorella virus
mutant with deleted C-terminal five amino acids: mutant shows 2% the specific activity of wild-type. Preformed Lig-AMP in vivo: 67% of total enzyme (wild-type: 70%), preformed Lig-AMP in vitro: 1.3% of total enzyme (wild-type: 21%)
CDELTA4
Paramecium bursaria chlorella virus
mutant with deleted C-terminal five amino acids: mutant shows 1% the specific activity of wild-type. Preformed Lig-AMP in vivo: 18% of total enzyme (wild-type: 70%), preformed Lig-AMP in vitro: 0.8% of total enzyme (wild-type: 21%)
CDELTA5
Paramecium bursaria chlorella virus
mutant with deleted C-terminal five amino acids: mutant shows 1% the specific activity of wild-type and is poorly responsive to ATP. Preformed Lig-AMP in vivo: 7% of total enzyme (wild-type: 70%), preformed Lig-AMP in vitro: 0.5% of total enzyme (wild-type: 21%)
D297A
Paramecium bursaria chlorella virus
preformed Lig-AMP in vivo: 76% of total enzyme (wild-type: 70%), preformed Lig-AMP in vitro: 2.9% of total enzyme (wild-type: 21%)
D297E
Paramecium bursaria chlorella virus
preformed Lig-AMP in vivo: 74% of total enzyme (wild-type: 70%), preformed Lig-AMP in vitro: 1.8% of total enzyme (wild-type: 21%)
D297N
Paramecium bursaria chlorella virus
preformed Lig-AMP in vivo: 60% of total enzyme (wild-type: 70%), preformed Lig-AMP in vitro: 2.8% of total enzyme (wild-type: 21%)
R293A
Paramecium bursaria chlorella virus
preformed Lig-AMP in vivo: 52% of total enzyme (wild-type: 70%), preformed Lig-AMP in vitro: 1.9% of total enzyme (wild-type: 21%)
R293K
Paramecium bursaria chlorella virus
preformed Lig-AMP in vivo: 70% of total enzyme (wild-type: 70%), preformed Lig-AMP in vitro: 3.4% of total enzyme (wild-type: 21%)
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PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
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CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Samai, P.; Shuman, S.
Kinetic analysis of DNA strand joining by Chlorella virus DNA ligase and the role of nucleotidyltransferase motif VI in ligase adenylylation
J. Biol. Chem.
287
28609-28618
2012
Paramecium bursaria chlorella virus (O41026)
brenda
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Release 2023.1 (January 2023)
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