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Information on EC 6.4.1.7 - 2-oxoglutarate carboxylase for references in articles please use BRENDA:EC6.4.1.7
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EC Tree
The enzyme appears in viruses and cellular organisms
Synonyms
carboxylating factor for ICDH, CFI, OGC, oxalosuccinate synthetase,
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carboxylating factor for ICDH
oxalosuccinate synthetase
carboxylating factor for ICDH
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incorrect
carboxylating factor for ICDH
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incorrect
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CFI
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OGC
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oxalosuccinate synthetase
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oxalosuccinate synthetase
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ATP + 2-oxoglutarate + HCO3- = ADP + phosphate + oxalosuccinate
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ATP + 2-oxoglutarate + HCO3-
ADP + phosphate + oxalosuccinate
ATP + 2-oxoglutarate + HCO3-
ADP + phosphate + oxalosuccinate
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-
-
-
?
ATP + 2-oxoglutarate + HCO3-
ADP + phosphate + oxalosuccinate
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first step of the reductive carboxylation from 2-oxoglutarate to isocitrate. Oxalosuccinate, the product of the reaction is unstable and is quickly converted into isocitrate by the action of EC 1.1.1.41
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-
?
ATP + 2-oxoglutarate + HCO3-
ADP + phosphate + oxalosuccinate
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-
-
-
?
ATP + 2-oxoglutarate + HCO3-
ADP + phosphate + oxalosuccinate
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first step of the reductive carboxylation from 2-oxoglutarate to isocitrate. Oxalosuccinate, the product of the reaction is unstable and is quickly converted into isocitrate by the action of EC 1.1.1.41
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-
?
ATP + 2-oxoglutarate + HCO3-
ADP + phosphate + oxalosuccinate
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-
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?
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ATP + 2-oxoglutarate + HCO3-
ADP + phosphate + oxalosuccinate
ATP + 2-oxoglutarate + HCO3-
ADP + phosphate + oxalosuccinate
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-
-
-
?
ATP + 2-oxoglutarate + HCO3-
ADP + phosphate + oxalosuccinate
-
first step of the reductive carboxylation from 2-oxoglutarate to isocitrate. Oxalosuccinate, the product of the reaction is unstable and is quickly converted into isocitrate by the action of EC 1.1.1.41
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-
?
ATP + 2-oxoglutarate + HCO3-
ADP + phosphate + oxalosuccinate
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-
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-
?
ATP + 2-oxoglutarate + HCO3-
ADP + phosphate + oxalosuccinate
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first step of the reductive carboxylation from 2-oxoglutarate to isocitrate. Oxalosuccinate, the product of the reaction is unstable and is quickly converted into isocitrate by the action of EC 1.1.1.41
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biotin
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enzyme contains biotin
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1.03
2-oxoglutarate
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pH 8.5, 20°C
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30.6
2-oxoglutarate
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pH 8.5, 20°C
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4.9
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isoelectric focusing
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TK-6
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brenda
TK-6
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brenda
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brenda
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49000
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x * 72000 + x * 49000, likely subunit structure alpha8beta8, SDS-PAGE
72000
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x * 72000 + x * 49000, likely subunit structure alpha8beta8, SDS-PAGE
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?
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x * 72000 + x * 49000, likely subunit structure alpha8beta8, SDS-PAGE
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x * 72000 + x * 49000, likely subunit structure alpha8beta8, SDS-PAGE
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4°C, stable for at least 1 month
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a fragment containing alpha and beta subunit genes is engineered for heterologous expression in Escherichia coli
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expression in Escherichia coli
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Keech, D.B.; Mattoo, A.K.; Carabott, M.J.J.; Wallace, J.C.
The ATP-dependent reductive carboxylation of 2-oxoglutarate using cytosol from rat liver
Biochem. Biophys. Res. Commun.
71
712-718
1976
Rattus norvegicus
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Aoshima, M.; Ishii, M.; Igarashi, Y.
A novel biotin protein required for reductive carboxylation of 2-oxoglutarate by isocitrate dehydrogenase in Hydrogenobacter thermophilus TK-6
Mol. Microbiol.
51
791-798
2004
Hydrogenobacter thermophilus, Hydrogenobacter thermophilus TK-6 / IAM 12695
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Aoshima, M.; Igarashi, Y.
A novel oxalosuccinate-forming enzyme involved in the reductive carboxylation of 2-oxoglutarate in Hydrogenobacter thermophilus TK-6
Mol. Microbiol.
62
748-759
2006
Hydrogenobacter thermophilus, Hydrogenobacter thermophilus TK-6 / IAM 12695
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6.4.1.7 2-oxoglutarate carboxylase
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