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Information on EC 6.4.1.3 - propionyl-CoA carboxylase and Organism(s) Rattus norvegicus and UniProt Accession P14882

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EC Tree
IUBMB Comments
A biotinyl-protein. Also carboxylates butanoyl-CoA and catalyses transcarboxylation.
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This record set is specific for:
Rattus norvegicus
UNIPROT: P14882
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Word Map
The taxonomic range for the selected organisms is: Rattus norvegicus
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria, Archaea
Synonyms
propionyl-coa carboxylase, pccbc, propionyl-coenzyme a carboxylase, acetyl-coa/propionyl-coa carboxylase, pcca-1, pccb-1, pccase, propanoyl-coa:carbon-dioxide ligase (adp-forming), more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Propionyl-CoA carboxylase
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Carboxylase, propional coenzyme A (adenosine triphosphate-hydrolyzing)
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Pcase
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-
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PCC
-
-
-
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PCCase
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-
-
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Propanoyl-CoA:carbon dioxide ligase
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-
-
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Propionyl coenzyme A carboxylase
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-
-
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Propionyl coenzyme A carboxylase (adenosine triphosphate-hydrolyzing)
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-
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Propionyl coenzyme A carboxylase (ATP-hydrolyzing)
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-
-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
carboxylation
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-
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SYSTEMATIC NAME
IUBMB Comments
propanoyl-CoA:carbon-dioxide ligase (ADP-forming)
A biotinyl-protein. Also carboxylates butanoyl-CoA and catalyses transcarboxylation.
CAS REGISTRY NUMBER
COMMENTARY hide
9023-94-3
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
show the reaction diagram
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
ATP + propanoyl-CoA + HCO3-
ADP + phosphate + (S)-methylmalonyl-CoA
show the reaction diagram
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key enzyme in catabolic pathways for odd-chain fatty acids and branched chain amino acids
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?
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
biotin
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bound to enzyme, very low activity when rats fed a biotin deficient diet for more than 2 weeks, in cell culture normal activity recovered 24 h after addition of biotin
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
embryo, in the periventricular zones
Manually annotated by BRENDA team
adult, highest level
Manually annotated by BRENDA team
additional information
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
metabolism
methylmalonyl-CoA mutase and PCC are key enzmyes in the catabolic pathway of propionate metabolism in the developing and adult rat central nervous system
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
PCCA_RAT
737
0
81623
Swiss-Prot
Mitochondrion (Reliability: 1)
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
72000
70000
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x * 70000, propionyl-coA carboxylase alpha chain, mass spectrometry
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
?
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x * 70000, propionyl-coA carboxylase alpha chain, mass spectrometry
multimer
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alpha,beta, alpha subunit: 72000 Da
additional information
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propionyl-coA carboxylase alpha chain associates with neurofibromin
EXPRESSION
ORGANISM
UNIPROT
LITERATURE
in rat embryos (E15.5 and E18.5), methylmalonyl-CoA mutase and PCC show a much higher expression level in the entire central nervous system than in the liver
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Rodriguez-Melendez, R.; Perez-Andrade, M.E.; Diaz, A.; Deolarte, A.; Camacho-Arroyo, I.; Ciceron, I.; Ibarra, I.; Velazquez, A.
Differential effects of biotin deficiency and replenishment on rat liver pyruvate and propionyl-CoA carboxylases and on their mRNAs
Mol. Genet. Metab.
66
16-23
1999
Rattus norvegicus
Manually annotated by BRENDA team
Lin, Y.L.; Hsueh, Y.P.
Neurofibromin interacts with CRMP-2 and CRMP-4 in rat brain
Biochem. Biophys. Res. Commun.
369
747-752
2008
Rattus norvegicus
Manually annotated by BRENDA team
Ballhausen, D.; Mittaz, L.; Boulat, O.; Bonafe, L.; Braissant, O.
Evidence for catabolic pathway of propionate metabolism in CNS: expression pattern of methylmalonyl-CoA mutase and propionyl-CoA carboxylase alpha-subunit in developing and adult rat brain
Neuroscience
164
578-587
2009
Rattus norvegicus (P14882)
Manually annotated by BRENDA team