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Information on EC 6.4.1.11 - polyporic acid synthase

for references in articles please use BRENDA:EC6.4.1.11

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IUBMB Comments

Requires Mg2+. The enzyme, found in mushrooms of the Basidiomycota and Ascomycota phyla, is a non-ribosomal peptide synthase-like enzyme comprising three domains - an adelylation (A) domain, an ayl-carrier protein (ACP) domain, and a thioesterase (TE) domain. The enzyme activates 3-phenyl-2-oxopropanoate by adenylation and catalyses the dimerization/cyclization of two such molecules to form polyporic acid. Polyporic acid is a precursor for assorted metabolites produced by the fungi, such as the corticins.

The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Reaction Schemes
hide(Overall reactions are displayed. Show all >>)
2
ATP
+
2
3-phenyl-2-oxopropanoate
=
2
AMP
+
2
diphosphate
+
polyporic acid
2
+
2
=
2
+
2
+
polyporic acid

Synonyms
AcyN, CorA, EchA, hapA1, hapA2, polyporic acid synthetase, PpaA1, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
2 ATP + 2 3-phenyl-2-oxopropanoate = 2 AMP + 2 diphosphate + polyporic acid
show the reaction diagram
overall reaction
-
-
-
ATP + 3-phenyl-2-oxopropanoate + 3-pheny-2-oxopropanoyl-[polyporic acid synthase] = AMP + diphosphate + polyporic acid + [polyporic acid synthase]
show the reaction diagram
(1b)
-
-
-
ATP + 3-phenyl-2-oxopropanoate + [polyporic acid synthase] = AMP + diphosphate + 3-pheny-2-oxopropanoyl-[polyporic acid synthase]
show the reaction diagram
(1a)
-
-
-
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