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Disease on EC 6.4.1.1 - pyruvate carboxylase

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DISEASE
TITLE OF PUBLICATION
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Acidosis
Brain pyruvate carboxylase and the pathophysiology of biotin-dependent diseases.
Carbon flux through tricarboxylic acid cycle in rat renal tubules.
Case report of Takotsubo syndrome following seizures in a patient with pyruvate carboxylase deficiency.
Is pyruvate carboxylase involved in the renal tubular reabsorption of bicarbonate?
Neonatal pyruvate carboxylase deficiency with renal tubular acidosis and cystinuria.
Pyruvate carboxylase and phosphoenolpyruvate carboxykinase activity in leukocytes and fibroblasts from a patient with pyruvate carboxylase deficiency.
Pyruvate carboxylase deficiency and lactic acidosis in a retarded child without Leigh's disease.
Pyruvate carboxylase deficiency--insights from liver transplantation.
Pyruvate carboxylase deficiency: acute exacerbation after ACTH treatment of infantile spasms.
Pyruvate carboxylase in human liver. Apparent loss of a component of catalytic activity in a form of lactic acidosis with hypoglycemia.
Thiamine-responsive lactice acidosis in a patient with deficient low-KM pyruvate carboxylase activity in liver.
[Effect of artificial hibernation state on intensity of metabolic processes in rabbits]
Acidosis, Lactic
A case of pyruvate carboxylase deficiency with later prenatal diagnosis of an unaffected sibling.
A Unique Case of Pyruvate Carboxylase Deficiency.
Biochemical and histologic pathology in an infant with cross-reacting material (negative) pyruvate carboxylase deficiency.
Biochemical studies in mitochondrial encephalomyopathy.
Brain amino acid abnormalities in pyruvate carboxylase deficiency.
Clinical signs of fatty liver and kidney syndrome in broilers and their alleviation by the short-term use of biotin or animal tallow.
Congenital lactic acidosis associated with pyruvate carboxylase deficiency.
Congenital lactic acidosis associated with pyruvate carboxylase deficiency. Repository identification No. GM6056.
Congenital lactic acidosis due to pyruvate carboxylase deficiency: absence of an inhibitor of TPP-ATP phosphoryl transferase.
Hyperalaninemia hyperpyruvicemia and lactic acidosis due to pyruvate carboxylase deficiency of the liver; treatment with thiamine and lipoic acid.
Increased prevalence of hereditary metabolic diseases among native Indians in Manitoba and northwestern Ontario.
Intron retention and frameshift mutations result in severe pyruvate carboxylase deficiency in two male siblings.
Lactic acidosis due to pyruvate carboxylase deficiency.
Neonatal congenital lactic acidosis with pyruvate carboxylase deficiency in two siblings.
Pathogenic mechanism, prophylaxis, and therapy of symptomatic acidosis induced by acetazolamide.
Prolonged survival in pyruvate carboxylase deficiency: lack of correlation with enzyme activity in cultured fibroblasts.
Pyruvate carboxylase deficiency and lactic acidosis in a retarded child without Leigh's disease.
Pyruvate carboxylase deficiency: acute exacerbation after ACTH treatment of infantile spasms.
Pyruvate carboxylase deficiency: An underestimated cause of lactic acidosis.
Pyruvate carboxylase in human liver. Apparent loss of a component of catalytic activity in a form of lactic acidosis with hypoglycemia.
Pyruvate-carboxylase deficiency with urea cycle impairment.
The measurement of propionyl-CoA carboxylase and pyruvate carboxylase activity in hair roots: its use in the diagnosis of inherited biotin-dependent enzyme deficiencies.
[Neonatal lactic acidosis caused by severe pyruvate carboxylase deficiency]
Acidosis, Renal Tubular
Is pyruvate carboxylase involved in the renal tubular reabsorption of bicarbonate?
Neonatal pyruvate carboxylase deficiency with renal tubular acidosis and cystinuria.
Pyruvate carboxylase and phosphoenolpyruvate carboxykinase activity in leukocytes and fibroblasts from a patient with pyruvate carboxylase deficiency.
Pyruvate carboxylase deficiency and lactic acidosis in a retarded child without Leigh's disease.
Adenocarcinoma
[Expression and clinical significance of pyruvate carboxylase in gastric adenocarcinoma].
Adenocarcinoma of Lung
piR-hsa-211106 Inhibits the Progression of Lung Adenocarcinoma Through Pyruvate Carboxylase and Enhances Chemotherapy Sensitivity.
Alzheimer Disease
Pyruvate Carboxylase and Pentose Phosphate Fluxes are Reduced in A?PP-PS1 Mouse Model of Alzheimer's Disease: A 13C NMR Study.
Anaphylaxis
Pycnogenol((R)) inhibits immunoglobulin E-mediated allergic response in mast cells.
Apraxias
[Congenital oculomotor apraxia and partial deficiency of pyruvate carboxylase]
Arthritis
Pycnogenol attenuates the inflammatory and nitrosative stress on joint inflammation induced by urate crystals.
RSA, TSA and PyC hemi-prostheses: comparing indications and clinical outcomes using a second-generation modular short-stem shoulder prosthesis.
arylsulfatase (type i) deficiency
Antenatal manifestations of inborn errors of metabolism: autopsy findings suggestive of a metabolic disorder.
aspartate-ammonia ligase deficiency
Antenatal manifestations of inborn errors of metabolism: autopsy findings suggestive of a metabolic disorder.
Asthma
Inhibitory effects of Pycnogenol® (French maritime pine bark extract) on airway inflammation in ovalbumin-induced allergic asthma.
Astrocytoma
Exploiting Metabolic Differences in Glioma Therapy.
Expression of pyruvate carboxylase in cultured human astrocytoma, glioblastoma and neuroblastoma cells.
Neuronal-astrocyte metabolic interactions: understanding the transition into abnormal astrocytoma metabolism.
Atherosclerosis
Pycnogenol attenuates atherosclerosis by regulating lipid metabolism through the TLR4-NF-?B pathway.
Pycnogenol, an extract from French maritime pine, suppresses Toll-like receptor 4-mediated expression of adipose differentiation-related protein in macrophages.
PycnogenolR Reduces Toll-like Receptor 4 Signaling Pathway-mediated Atherosclerosis Formation in Apolipoprotein E-Deficient Mice.
biotin-[propionyl-coa-carboxylase (atp-hydrolysing)] ligase deficiency
[Delayed onset holocarboxylase synthetase deficiency with normal pyruvate carboxylase activity.]
Bone Diseases
Inhibitory effects of French pine bark extract, pycnogenol(®) , on alveolar bone resorption and on the osteoclast differentiation.
Bone Resorption
Inhibitory effects of French pine bark extract, pycnogenol(®) , on alveolar bone resorption and on the osteoclast differentiation.
Brain Contusion
Neuroprotective effect of Pycnogenol® following traumatic brain injury.
Brain Diseases
Biochemical studies in mitochondrial encephalomyopathy.
Challenges in the management of an ignored cause of hyperammonemic encephalopathy: pyruvate carboxylase deficiency.
Leigh's necrotizing encephalopathy with pyruvate carboxylase deficiency.
Pyruvate carboxylase activity in subacute necrotizing encephalopathy (Leigh's disease).
[Case of methylmalonic acidemia presenting clinically Leigh encephalopathy]
Brain Edema
The anaplerotic flux and ammonia detoxification in hepatic encephalopathy.
Brain Injuries
Evaluation of the Neuroprotective Effect of Pycnogenol in a Hypoxic-Ischemic Brain Injury Model in Newborn Rats.
Brain Injuries, Traumatic
Glucose metabolism after traumatic brain injury: estimation of pyruvate carboxylase and pyruvate dehydrogenase flux by mass isotopomer analysis.
Breast Neoplasms
1?,25-dihydroxyvitamin D inhibits de novo fatty acid synthesis and lipid accumulation in metastatic breast cancer cells through down-regulation of pyruvate carboxylase.
c-Myc directly targets an over-expression of pyruvate carboxylase in highly invasive breast cancer.
Impaired G2/M cell cycle arrest induces apoptosis in pyruvate carboxylase knockdown MDA-MB-231 cells.
Inhibition of pyruvate carboxylase by 1?,25-dihydroxyvitamin D promotes oxidative stress in early breast cancer progression.
Mass spectrometry analysis shows the biosynthetic pathways supported by pyruvate carboxylase in highly invasive breast cancer cells.
Pyruvate Carboxylase Is Up-Regulated in Breast Cancer and Essential to Support Growth and Invasion of MDA-MB-231 Cells.
Pyruvate carboxylase supports the pulmonary tropism of metastatic breast cancer.
Targeting Pyruvate Carboxylase by a Small Molecule Suppresses Breast Cancer Progression.
Brucellosis
Promotion of platelet aggregation by sera from brucellosis patients with antiphosphatidylcholine antibodies.
carbonic anhydrase deficiency
Mitochondrial Carbonic Anhydrase VA Deficiency Resulting from CA5A Alterations Presents with Hyperammonemia in Early Childhood.
Carcinogenesis
Long Noncoding RNA CTD-2245E15.3 Promotes Anabolic Enzymes ACC1 and PC to Support Non-Small Cell Lung Cancer Growth.
Pycnogenol reduces talc-induced neoplastic transformation in human ovarian cell cultures.
Pyruvate Carboxylase Drives Tumorigenesis of SDH-Deficient Cells.
Value of Pyruvate Carboxylase in Thyroid Fine-Needle Aspiration Wash-Out Fluid for Predicting Papillary Thyroid Cancer Lymph Node Metastasis.
Carcinoma
An In Vitro Study on the Interactions of Pycnogenol® with Cisplatin in Human Cervical Cancer Cells.
Carcinoma, Hepatocellular
Active pyruvate dehydrogenase and impaired gluconeogenesis in orthotopic hepatomas of rats.
Activities of key gluconeogenic enzymes and glycogen synthase in rat and human livers, hepatomas, and hepatoma cell cultures.
Supplementing Conventional Treatment with Pycnogenol® May Improve Hepatitis C Virus-Associated Type 2 Diabetes: A Mini Review.
Cardiotoxicity
Effect of PYCNOGENOL on the toxicity of heart, bone marrow and immune organs as induced by antitumor drugs.
Cardiovascular Diseases
A review of the French maritime pine bark extract (Pycnogenol), a herbal medication with a diverse clinical pharmacology.
Supplementing Conventional Treatment with Pycnogenol® May Improve Hepatitis C Virus-Associated Type 2 Diabetes: A Mini Review.
Citrullinemia
Prenatal diagnosis of pyruvate carboxylase deficiency.
Pyruvate-carboxylase deficiency with urea cycle impairment.
Secondary citrullinemia with hyperammonemia in four neonatal cases of pyruvate carboxylase deficiency.
The molecular basis for the two different clinical presentations of classical pyruvate carboxylase deficiency.
Colonic Neoplasms
Overexpression of Pyruvate Carboxylase Is Correlated With Colorectal Cancer Progression and Supports Growth of Invasive Colon Cancer HT-29 Cell Line.
Colorectal Neoplasms
Overexpression of Pyruvate Carboxylase Is Correlated With Colorectal Cancer Progression and Supports Growth of Invasive Colon Cancer HT-29 Cell Line.
Coma
Selective increase of brain lactate synthesis in experimental acute liver failure: results of a [H-C] nuclear magnetic resonance study.
Congenital Abnormalities
Studies on the biotin requirement of broilers fed sunflower seed meal based diets.
Congenital Disorders of Glycosylation
Antenatal manifestations of inborn errors of metabolism: autopsy findings suggestive of a metabolic disorder.
Congenital, Hereditary, and Neonatal Diseases and Abnormalities
Antenatal manifestations of inborn errors of metabolism: autopsy findings suggestive of a metabolic disorder.
COVID-19
SARS-CoV-2 infection rewires host cell metabolism and is potentially susceptible to mTORC1 inhibition.
Cystinuria
Neonatal pyruvate carboxylase deficiency with renal tubular acidosis and cystinuria.
Cysts
Prenatal sonographic description of fetuses affected by pyruvate dehydrogenase or pyruvate carboxylase deficiency.
Diabetes Complications
Protective effects of Pycnogenol((R)) on hyperglycemia-induced oxidative damage in the liver of type 2 diabetic rats.
Diabetes Mellitus
Effect of streptozotocin-induced diabetes mellitus on the turnover of rat liver pyruvate carboxylase and pyruvate dehydrogenase.
Reduction of islet pyruvate carboxylase activity might be related to the development of type 2 diabetes mellitus in Agouti-K mice.
Diabetes Mellitus, Type 1
FGF1 and FGF19 reverse diabetes by suppression of the hypothalamic-pituitary-adrenal axis.
Diabetes Mellitus, Type 2
Low mitochondrial glycerol phosphate dehydrogenase and pyruvate carboxylase in pancreatic islets of Zucker diabetic fatty rats.
Normalization by insulin treatment of low mitochondrial glycerol phosphate dehydrogenase and pyruvate carboxylase in pancreatic islets of the GK rat.
Reduction of islet pyruvate carboxylase activity might be related to the development of type 2 diabetes mellitus in Agouti-K mice.
Regulation of pyruvate metabolism in metabolic-related diseases.
Targeting pyruvate carboxylase reduces gluconeogenesis and adiposity and improves insulin resistance.
Diabetic Cardiomyopathies
Glucose and blood pressure lowering effects of Pycnogenol(®) are inefficient to prevent prolongation of QT interval in experimental diabetic cardiomyopathy.
Diabetic Ketoacidosis
Pyruvate Carboxylase Deficiency Mimicking Diabetic Ketoacidosis.
Pyruvate carboxylase deficiency type C as a differential diagnosis of diabetic ketoacidosis.
Diffuse Cerebral Sclerosis of Schilder
[Alpers' infantile cerebral poliodystrophy. A case with abnormal hepatic pyruvate carboxylase]
Epilepsy
Corrigendum to 'Angiocentric glioma-associated seizures: The possible role of EATT2, pyruvate carboxylase and glutamine synthetase [Seizure: European Journal of Epilepsy 86 (2021) 152-154].
Ketogenic diet: an early option for epilepsy treatment, instead of a last choice only.
Erythema
A review of the French maritime pine bark extract (Pycnogenol), a herbal medication with a diverse clinical pharmacology.
Fatty Liver
Pycnogenol
Studies on the biotin requirement of broilers fed sunflower seed meal based diets.
The biochemistry of fatty liver and kidney syndrome. Biotin-mediated restoration of hepatic gluconeogenesis in vitro and its relationship to pyruvate carboxylase activity.
Fibrosarcoma
Pycnogenol (PYC) induces apoptosis in human fibrosarcoma (HFS) cells under metal-mediated oxidative stress.
Friedreich Ataxia
Friedreich ataxia and low pyruvate carboxylase activity in liver and fibroblasts.
Pyruvate carboxylase activity is not abnormal in fibroblasts of patients with Friedreich's ataxia.
fructose-bisphosphatase deficiency
Lactic acidosis in childhood.
Glioblastoma
Expression of pyruvate carboxylase in cultured human astrocytoma, glioblastoma and neuroblastoma cells.
Glutamate-Oxaloacetate Transaminase 1 Impairs Glycolysis by Interacting with Pyruvate Carboxylase and Further Inhibits the Malignant Phenotypes of Glioblastoma Cells.
Glioma
Angiocentric glioma-associated seizures: The possible role of EATT2, pyruvate carboxylase and glutamine synthetase.
Glioma cells with the IDH1 mutation modulate metabolic fractional flux through pyruvate carboxylase.
Macro-, Micro- and Nano-Roughness of Carbon-Based Interface with the Living Cells: Towards a Versatile Bio-Sensing Platform.
Glycogen Storage Disease
Antenatal manifestations of inborn errors of metabolism: autopsy findings suggestive of a metabolic disorder.
Glycogen storage disease type I and III and pyruvate carboxylase deficiency: results of long-term treatment with uncooked cornstarch.
Lactic acidosis in childhood.
Glycogen Storage Disease Type I
Glycogen storage disease type I and III and pyruvate carboxylase deficiency: results of long-term treatment with uncooked cornstarch.
Glycogen Storage Disease Type III
Glycogen storage disease type I and III and pyruvate carboxylase deficiency: results of long-term treatment with uncooked cornstarch.
Hepatic Encephalopathy
Aspartate aminotransferase, malate dehydrogenase, and pyruvate carboxylase activities in rat cerebral synaptic and nonsynaptic mitochondria: effects of in vitro treatment with ammonia, hyperammonemia and hepatic encephalopathy.
Hepatitis C
Nonstructural 5A protein of hepatitis C virus interacts with pyruvate carboxylase and modulates viral propagation.
Holocarboxylase Synthetase Deficiency
[Delayed onset holocarboxylase synthetase deficiency with normal pyruvate carboxylase activity.]
Huntington Disease
Changes in nine enzyme markers for neurons, glia, and endothelial cells in agonal state and Huntington's disease caudate nucleus.
Hypercholesterolemia
The clinical and biochemical implications of pyruvate carboxylase deficiency.
Hyperglycemia
Modulatory effects of Pycnogenol® in a rat model of insulin-dependent diabetes mellitus: biochemical, histological, and immunohistochemical evidences.
Normalization by insulin treatment of low mitochondrial glycerol phosphate dehydrogenase and pyruvate carboxylase in pancreatic islets of the GK rat.
Physical exercise reduces pyruvate carboxylase (PCB) and contributes to hyperglycemia reduction in obese mice.
Protective effects of Pycnogenol((R)) on hyperglycemia-induced oxidative damage in the liver of type 2 diabetic rats.
Reduction of islet pyruvate carboxylase activity might be related to the development of type 2 diabetes mellitus in Agouti-K mice.
The pathogenesis of insulin resistance: integrating signaling pathways and substrate flux.
Hyperglycinemia, Nonketotic
Antenatal manifestations of inborn errors of metabolism: autopsy findings suggestive of a metabolic disorder.
Hyperlysinemias
Plasma lysine concentration and availability of 2-ketoglutarate in liver mitochondria.
The molecular basis for the two different clinical presentations of classical pyruvate carboxylase deficiency.
Hyperoxaluria, Primary
Increased prevalence of hereditary metabolic diseases among native Indians in Manitoba and northwestern Ontario.
Hypersensitivity
Biotin supplementation of practical diets for channel catfish.
Hypertension
Glucose and blood pressure lowering effects of Pycnogenol(®) are inefficient to prevent prolongation of QT interval in experimental diabetic cardiomyopathy.
Hyperthyroidism
Effect of thyroid hormone on the turnover of rat liver pyruvate carboxylase and pyruvate dehydrogenase.
Pyruvate carboxylase.
Hypertrophy, Left Ventricular
The Effects of Pycnogenol® as Add-on Drug to Metformin Therapy in Diabetic Rats.
Hypoglycemia
A Unique Case of Pyruvate Carboxylase Deficiency.
Comparative frequency and severity of hypoglycemia in selected organic acidemias, branched chain amino acidemia, and disorders of fructose metabolism.
Genomic organization of the human gene (CA5) and pseudogene for mitochondrial carbonic anhydrase V and their localization to chromosomes 16q and 16p.
Pyruvate carboxylase in human liver. Apparent loss of a component of catalytic activity in a form of lactic acidosis with hypoglycemia.
Hypophosphatasia
Antenatal manifestations of inborn errors of metabolism: autopsy findings suggestive of a metabolic disorder.
Infections
Growth and Stress Tolerance Comprise Independent Metabolic Strategies Critical for Staphylococcus aureus Infection.
In situ assays demonstrate that interferon-gamma suppresses infection-stimulated hepatic fibrin deposition by promoting fibrinolysis.
Inhibitory effects of French pine bark extract, pycnogenol(®) , on alveolar bone resorption and on the osteoclast differentiation.
Metabolic responses of primary and transformed cells to intracellular Listeria monocytogenes.
Roles of pyruvate carboxylase in human diseases: from diabetes to cancers and infection.
Insulin Resistance
beta-Cell adaptation to insulin resistance. Increased pyruvate carboxylase and malate-pyruvate shuttle activity in islets of nondiabetic Zucker fatty rats.
Reduction of islet pyruvate carboxylase activity might be related to the development of type 2 diabetes mellitus in Agouti-K mice.
Targeting pyruvate carboxylase reduces gluconeogenesis and adiposity and improves insulin resistance.
Insulinoma
Differences between human and rodent pancreatic islets: low pyruvate carboxylase, ATP citrate lyase and pyruvate carboxylation; high glucose-stimulated acetoacetate in human pancreatic islets.
Glucose induces expression of rat pyruvate carboxylase through a carbohydrate response element in the distal gene promoter.
Impaired Anaplerosis and Insulin Secretion in Insulinoma Cells Caused by Small Interfering RNA-mediated Suppression of Pyruvate Carboxylase.
Influence of glucose on pyruvate carboxylase expression in pancreatic islets.
Knockdown of pyruvate carboxylase or fatty acid synthase lowers numerous lipids and glucose-stimulated insulin release in insulinoma cells.
Regulation of islet beta-cell pyruvate metabolism: interactions of prolactin, glucose, and dexamethasone.
Transcriptional regulation of the distal promoter of the rat pyruvate carboxylase gene by hepatocyte nuclear factor 3beta/Foxa2 and upstream stimulatory factors in insulinoma cells.
Intellectual Disability
Lactic acidaemia.
Iron Deficiencies
Synergistic inhibitory effects of hypoxia and iron deficiency on hepatic glucose response in mouse liver.
Ketosis
ADSA Foundation Scholar Award: Influencing hepatic metabolism: Can nutrient partitioning be modulated to optimize metabolic health in the transition dairy cow?
Pathogenic mechanism, prophylaxis, and therapy of symptomatic acidosis induced by acetazolamide.
Pyruvate Carboxylase Deficiency Type C: A Rare Cause of Acute Transient Flaccid Paralysis with Ketoacidosis.
Pyruvate carboxylase deficiency--insights from liver transplantation.
Kwashiorkor
Biotin supplementation affects lymphocyte carboxylases and plasma biotin in severe protein-energy malnutrition.
Leigh Disease
Lactic acidosis in childhood.
Leigh's disease with decreased activities of pyruvate carboxylase and pyruvate decarboxylase.
Neurochemical changes in Leigh's disease.
Pyruvate carboxylase activity in subacute necrotizing encephalopathy (Leigh's disease).
Pyruvate carboxylase deficiency and lactic acidosis in a retarded child without Leigh's disease.
Pyruvate carboxylase deficiency: an alleged biochemical cause of Leigh's disease.
Renal function studies and kidney pyruvate carboxylase in subacute necrotizing encephalomyelopathy (Leigh's syndrome).
Studies on pyruvate carboxylase, pyruvate decarboxylase and lipoamide dehydrogenase in subacute necrotizing encephalomyelopathy.
[Suspected pyruvate carboxylase deficiency in 4 children with Leigh disease]
Leukopenia
Effect of PYCNOGENOL on the toxicity of heart, bone marrow and immune organs as induced by antitumor drugs.
Liver Diseases
Ameliorative effects of pycnogenol((R)) on carbon tetrachloride-induced hepatic oxidative damage in rats.
Pycnogenol
Targeting pyruvate carboxylase reduces gluconeogenesis and adiposity and improves insulin resistance.
Liver Failure
Aspartate aminotransferase, malate dehydrogenase, and pyruvate carboxylase activities in rat cerebral synaptic and nonsynaptic mitochondria: effects of in vitro treatment with ammonia, hyperammonemia and hepatic encephalopathy.
Lung Injury
Pycnogenol, a compound isolated from the bark of pinus maritime mill, attenuates ventilator-induced lung injury through inhibiting NF-?B-mediated inflammatory response.
Lung Neoplasms
Pyruvate carboxylase is critical for non-small-cell lung cancer proliferation.
Lymphatic Metastasis
Corrigendum: Value of Pyruvate Carboxylase in Thyroid Fine-Needle Aspiration Wash-Out Fluid for Predicting Papillary Thyroid Cancer Lymph Node Metastasis.
Value of Pyruvate Carboxylase in Thyroid Fine-Needle Aspiration Wash-Out Fluid for Predicting Papillary Thyroid Cancer Lymph Node Metastasis.
Lysosomal Storage Diseases
Antenatal manifestations of inborn errors of metabolism: autopsy findings suggestive of a metabolic disorder.
medium-chain acyl-coa dehydrogenase deficiency
Ketogenic diet.
Metabolic Diseases
Cryo-EM analysis reveals new insights into the mechanism of action of pyruvate carboxylase.
Pyruvate carboxylase deficiency: metabolic characteristics and new neurological aspects.
Triheptanoin for the treatment of brain energy deficit: A 14-year experience.
Metabolism, Inborn Errors
Plasma lysine concentration and availability of 2-ketoglutarate in liver mitochondria.
Mitochondrial Myopathies
Biochemical studies in mitochondrial encephalomyopathy.
Movement Disorders
A Unique Case of Pyruvate Carboxylase Deficiency.
Multiple Carboxylase Deficiency
Acetyl CoA carboxylase in cultured fibroblasts: differential biotin dependence in the two types of biotin-responsive multiple carboxylase deficiency.
Biochemical characterization of biotin-responsive multiple carboxylase deficiency: heterogeneity within the bio genetic complementation group.
Deficient acetyl CoA carboxylase activity in multiple carboxylase deficiency.
Lymphoblasts and diagnosis of pyruvate carboxylase deficiency.
Multiple carboxylase deficiency.
Multiple carboxylase deficiency: clinical and biochemical improvement following neonatal biotin treatment.
Muscle Hypotonia
Pyruvate carboxylase deficiency: acute exacerbation after ACTH treatment of infantile spasms.
Neoplasm Metastasis
Corrigendum: Value of Pyruvate Carboxylase in Thyroid Fine-Needle Aspiration Wash-Out Fluid for Predicting Papillary Thyroid Cancer Lymph Node Metastasis.
Value of Pyruvate Carboxylase in Thyroid Fine-Needle Aspiration Wash-Out Fluid for Predicting Papillary Thyroid Cancer Lymph Node Metastasis.
Neoplasms
13C NMR study of hepatic pyruvate carboxylase activity in tumor rats.
?9-THC increases endogenous AHA1 expression in rat cerebellum and may modulate CB1 receptor function during chronic use.
Altered regulation of metabolic pathways in human lung cancer discerned by (13)C stable isotope-resolved metabolomics (SIRM).
An In Vitro Study on the Interactions of Pycnogenol® with Cisplatin in Human Cervical Cancer Cells.
Bcl-2 inhibits tumor necrosis factor-alpha-mediated increase of glycolytic enzyme activities and enhances pyruvate carboxylase activity.
Cloning and real-time PCR testing of 14 potential biomarkers in Eisenia fetida following cadmium exposure.
Dietary supplementation with procyanidin-rich Pinus pinaster extract is associated with attenuated Ehrlich tumor development in mice.
Enzymatic and immunological studies on pyruvate carboxylase in livers and liver tumors.
Evaluation of the Neuroprotective Effect of Pycnogenol in a Hypoxic-Ischemic Brain Injury Model in Newborn Rats.
Generation of Human Pyruvate Carboxylase Knockout Cell Lines Using Retrovirus Expressing Short Hairpin RNA and CRISPR-Cas9 as Models to Study Its Metabolic Role in Cancer Research.
Immunohistochemical study of the distribution of endogenous biotin and biotin-binding enzymes in ductal structures of salivary gland tumours.
Inhibition of gluconeogenesis at the phosphoenolpyruvate carboxykinase and pyruvate carboxylase reactions, as a means of cancer chemotherapy.
Malonate as a ROS product is associated with pyruvate carboxylase activity in acute myeloid leukaemia cells.
Mass spectrometry analysis shows the biosynthetic pathways supported by pyruvate carboxylase in highly invasive breast cancer cells.
Modulatory effects of Pycnogenol® in a rat model of insulin-dependent diabetes mellitus: biochemical, histological, and immunohistochemical evidences.
Pycnogenol((R)) inhibits immunoglobulin E-mediated allergic response in mast cells.
Pyruvate carboxylase and cancer progression.
Pyruvate carboxylase is required for glutamine-independent growth of tumor cells.
Pyruvate carboxylase promotes thyroid cancer aggressiveness through fatty acid synthesis.
Pyruvate carboxylation enables growth of SDH-deficient cells by supporting aspartate biosynthesis.
Roles of pyruvate carboxylase in human diseases: from diabetes to cancers and infection.
Spirulina platensis prevents hyperglycemia in rats by modulating gluconeogenesis and apoptosis via modification of oxidative stress and MAPK-pathways.
The strong induction of metallothionein gene following cadmium exposure transiently affects the expression of many genes in Eisenia fetida: a trade-off mechanism?
Value of Pyruvate Carboxylase in Thyroid Fine-Needle Aspiration Wash-Out Fluid for Predicting Papillary Thyroid Cancer Lymph Node Metastasis.
[Inhibition effects of tumor necrosis factor-alpha gene transduced tumor drainage node of lymphocytes from tongue cancer on SCID mice transplanted tumor established with human tongue carcinoma cell lines]
Neuroblastoma
Expression of pyruvate carboxylase in cultured human astrocytoma, glioblastoma and neuroblastoma cells.
Protective effect of Pycnogenol in human neuroblastoma SH-SY5Y cells following acrolein-induced cytotoxicity.
Neurodegenerative Diseases
Antioxidant activity and biologic properties of a procyanidin-rich extract from pine (Pinus maritima) bark, pycnogenol.
Protective effect of Pycnogenol in human neuroblastoma SH-SY5Y cells following acrolein-induced cytotoxicity.
Neuroinflammatory Diseases
Protection of MPTP-induced neuroinflammation and neurodegeneration by Pycnogenol.
Non-alcoholic Fatty Liver Disease
Pycnogenol
Targeting pyruvate carboxylase reduces gluconeogenesis and adiposity and improves insulin resistance.
Obesity
Pycnogenol® Induces Browning of White Adipose Tissue through the PKA Signaling Pathway in Apolipoprotein E-Deficient Mice.
Pyruvate carboxylase in genetic obesity.
Strength exercise reduces hepatic pyruvate carboxylase and gluconeogenesis in DIO mice.
Osteoarthritis
RSA, TSA and PyC hemi-prostheses: comparing indications and clinical outcomes using a second-generation modular short-stem shoulder prosthesis.
Ovarian Neoplasms
Integrated analysis of transcriptomic and metabolomic data demonstrates the significant role of pyruvate carboxylase in the progression of ovarian cancer.
Pancreatic Neoplasms
Dissecting cell-type-specific metabolism in pancreatic ductal adenocarcinoma.
Paralysis
Pyruvate Carboxylase Deficiency Type C: A Rare Cause of Acute Transient Flaccid Paralysis with Ketoacidosis.
Parkinsonian Disorders
Infantile parkinsonism and gabaergic hypotransmission in a patient with pyruvate carboxylase deficiency.
peptidyl-glutamate 4-carboxylase deficiency
Acetyl CoA carboxylase in cultured fibroblasts: differential biotin dependence in the two types of biotin-responsive multiple carboxylase deficiency.
Biochemical characterization of biotin-responsive multiple carboxylase deficiency: heterogeneity within the bio genetic complementation group.
Deficient acetyl CoA carboxylase activity in multiple carboxylase deficiency.
Lymphoblasts and diagnosis of pyruvate carboxylase deficiency.
Multiple carboxylase deficiency.
Multiple carboxylase deficiency: clinical and biochemical improvement following neonatal biotin treatment.
The measurement of propionyl-CoA carboxylase and pyruvate carboxylase activity in hair roots: its use in the diagnosis of inherited biotin-dependent enzyme deficiencies.
Periodontitis
Inhibitory effects of French pine bark extract, pycnogenol(®) , on alveolar bone resorption and on the osteoclast differentiation.
Peroxisomal Disorders
Antenatal manifestations of inborn errors of metabolism: autopsy findings suggestive of a metabolic disorder.
phosphoenolpyruvate carboxylase deficiency
Hepatic phosphoenolpyruvate carboxykinase deficiency: a neonatal case with reduced activity of pyruvate carboxylase.
Porphyria, Acute Intermittent
Markers for vulnerability in acute porphyria. A hypothesis paper.
Porphyrias
Ketogenic diet.
Ketogenic diet: an early option for epilepsy treatment, instead of a last choice only.
Markers for vulnerability in acute porphyria. A hypothesis paper.
Propionic Acidemia
Comparative frequency and severity of hypoglycemia in selected organic acidemias, branched chain amino acidemia, and disorders of fructose metabolism.
Lactic acidosis in childhood.
Protein-Energy Malnutrition
Biotin supplementation affects lymphocyte carboxylases and plasma biotin in severe protein-energy malnutrition.
Pulmonary Disease, Chronic Obstructive
A standardized bark extract of Pinus pinaster Aiton (Pycnogenol(®)) attenuated chronic obstructive pulmonary disease via Erk-sp1 signaling pathway.
Pine bark extract (Pycnogenol®) suppresses cigarette smoke-induced fibrotic response via transforming growth factor-?1/Smad family member 2/3 signaling.
pyruvate carboxylase deficiency
A case of benign pyruvate carboxylase deficiency with normal development.
A case of pyruvate carboxylase deficiency with atypical clinical and neuroradiological presentation.
A case of pyruvate carboxylase deficiency with later prenatal diagnosis of an unaffected sibling.
A heuristic model for paradoxical effects of biotin starvation on carbon metabolism genes in the presence of abundant glucose.
A mutation of pyruvate carboxylase in fibroblasts from a patient with severe, chronic lactic acidaemia.
A Patient With Pyruvate Carboxylase Deficiency and Nemaline Rods on Muscle Biopsy.
A patient with pyruvate carboxylase deficiency in the liver: treatment with aspartic acid and thiamine.
A Unique Case of Pyruvate Carboxylase Deficiency.
Amerindian pyruvate carboxylase deficiency is associated with two distinct missense mutations.
An atypical French form of pyruvate carboxylase deficiency.
Antenatal manifestations of inborn errors of metabolism: autopsy findings suggestive of a metabolic disorder.
Biochemical and histologic pathology in an infant with cross-reacting material (negative) pyruvate carboxylase deficiency.
Brain amino acid abnormalities in pyruvate carboxylase deficiency.
Carrier detection of pyruvate carboxylase deficiency in fibroblasts and lymphocytes.
Case report of Takotsubo syndrome following seizures in a patient with pyruvate carboxylase deficiency.
Challenges in the management of an ignored cause of hyperammonemic encephalopathy: pyruvate carboxylase deficiency.
Comparative frequency and severity of hypoglycemia in selected organic acidemias, branched chain amino acidemia, and disorders of fructose metabolism.
Congenital lactic acidosis associated with pyruvate carboxylase deficiency.
Congenital lactic acidosis associated with pyruvate carboxylase deficiency. Repository identification No. GM6056.
Congenital lactic acidosis due to pyruvate carboxylase deficiency: absence of an inhibitor of TPP-ATP phosphoryl transferase.
Disorders of pyruvate carboxylase and the pyruvate dehydrogenase complex.
Disorders of pyruvate metabolism.
Evidence for two genetic complementation groups in pyruvate carboxylase-deficient human fibroblast cell lines.
Expression of pyruvate carboxylase in cultured oligodendroglial, microglial and ependymal cells.
Glycogen storage disease type I and III and pyruvate carboxylase deficiency: results of long-term treatment with uncooked cornstarch.
Hyperalaninemia hyperpyruvicemia and lactic acidosis due to pyruvate carboxylase deficiency of the liver; treatment with thiamine and lipoic acid.
Hyperalaninemia with pyruvicemia due to pyruvate carboxylase deficiency of the liver.
Increased prevalence of hereditary metabolic diseases among native Indians in Manitoba and northwestern Ontario.
Infantile parkinsonism and gabaergic hypotransmission in a patient with pyruvate carboxylase deficiency.
Intron retention and frameshift mutations result in severe pyruvate carboxylase deficiency in two male siblings.
Investigation of enzyme defects in children with lactic acidosis.
Ketogenic diet.
Ketogenic diet: an early option for epilepsy treatment, instead of a last choice only.
Lactic acidaemia.
Lactic acidosis due to pyruvate carboxylase deficiency.
Leigh's necrotizing encephalopathy with pyruvate carboxylase deficiency.
Lymphoblasts and diagnosis of pyruvate carboxylase deficiency.
Microdetermination of 2-ketoglutaric acid in plasma and cerebrospinal fluid by capillary gas chromatography mass spectrometry; application to pediatrics.
Mitochondrial Carbonic Anhydrase VA Deficiency Resulting from CA5A Alterations Presents with Hyperammonemia in Early Childhood.
Molecular characterization of pyruvate carboxylase deficiency in two consanguineous families.
MRI, clinical, and biochemical features of partial pyruvate carboxylase deficiency.
Neonatal congenital lactic acidosis with pyruvate carboxylase deficiency in two siblings.
Neonatal pyruvate carboxylase deficiency with renal tubular acidosis and cystinuria.
Novel Mutations in the PC Gene in Patients with Type B Pyruvate Carboxylase Deficiency.
Pathogenic mechanism, prophylaxis, and therapy of symptomatic acidosis induced by acetazolamide.
Plasma lysine concentration and availability of 2-ketoglutarate in liver mitochondria.
Prenatal diagnosis of pyruvate carboxylase deficiency by direct measurement of catalytic activity on chorionic villi samples.
Prenatal diagnosis of pyruvate carboxylase deficiency.
Prenatal onset of the neuroradiologic phenotype of pyruvate carboxylase deficiency due to homozygous PC c.1828G >?A mutations.
Prenatal sonographic description of fetuses affected by pyruvate dehydrogenase or pyruvate carboxylase deficiency.
Prolonged survival in pyruvate carboxylase deficiency: lack of correlation with enzyme activity in cultured fibroblasts.
Pyruvate carboxylase activity in subacute necrotizing encephalopathy (Leigh's disease).
Pyruvate carboxylase and phosphoenolpyruvate carboxykinase activity in leukocytes and fibroblasts from a patient with pyruvate carboxylase deficiency.
Pyruvate carboxylase defect: metabolic studies on cultured skin fibroblasts.
Pyruvate carboxylase deficiencies: complementation studies between "French" and "American" phenotypes in cultured fibroblasts.
Pyruvate carboxylase deficiency and lactic acidosis in a retarded child without Leigh's disease.
Pyruvate carboxylase deficiency in pleiotropic carbohydrate-negative mutant strains of Pseudomonas aeruginosa.
Pyruvate carboxylase deficiency in twins.
Pyruvate carboxylase deficiency in yeast: a mutant affecting the interaction between the glyoxylate and Krebs cycles.
Pyruvate Carboxylase Deficiency Mimicking Diabetic Ketoacidosis.
Pyruvate carboxylase deficiency type A and type C: Characterization of five novel pathogenic variants in PC and analysis of the genotype-phenotype correlation.
Pyruvate carboxylase deficiency type C as a differential diagnosis of diabetic ketoacidosis.
Pyruvate Carboxylase Deficiency Type C: A Rare Cause of Acute Transient Flaccid Paralysis with Ketoacidosis.
Pyruvate carboxylase deficiency--insights from liver transplantation.
Pyruvate carboxylase deficiency.
Pyruvate carboxylase deficiency. Report of a case and additional evidence for the "mild" phenotype.
Pyruvate carboxylase deficiency: a benign variant with normal development.
Pyruvate carboxylase deficiency: acute exacerbation after ACTH treatment of infantile spasms.
Pyruvate carboxylase deficiency: an alleged biochemical cause of Leigh's disease.
Pyruvate carboxylase deficiency: An underestimated cause of lactic acidosis.
Pyruvate carboxylase deficiency: clinical and biochemical response to anaplerotic diet therapy.
Pyruvate carboxylase deficiency: mechanisms, mimics and anaplerosis.
Pyruvate carboxylase deficiency: metabolic characteristics and new neurological aspects.
Pyruvate carboxylase deficiency: prenatal onset of ischemia-like brain lesions in two sibs with the acute neonatal form.
Pyruvate carboxylase in the yeast pyc mutant.
Report of a patient with severe, chronic lactic acidaemia and pyruvate carboxylase deficiency.
Secondary citrullinemia with hyperammonemia in four neonatal cases of pyruvate carboxylase deficiency.
Some biochemical observations on biotin deficiency in the rat as a model for human pyruvate carboxylase deficiency.
Structural insights on pathogenic effects of novel mutations causing pyruvate carboxylase deficiency.
Studies on pyruvate carboxylase from cultured human fibroblasts and amniotic fluid cells.
Studies on pyruvate carboxylase, pyruvate decarboxylase and lipoamide dehydrogenase in subacute necrotizing encephalomyelopathy.
The clinical and biochemical implications of pyruvate carboxylase deficiency.
The French and North American phenotypes of pyruvate carboxylase deficiency, correlation with biotin containing protein by 3H-biotin incorporation, 35S-streptavidin labeling, and Northern blotting with a cloned cDNA probe.
The genetic heterogeneity of lactic acidosis: occurrence of recognizable inborn errors of metabolism in pediatric population with lactic acidosis.
The measurement of propionyl-CoA carboxylase and pyruvate carboxylase activity in hair roots: its use in the diagnosis of inherited biotin-dependent enzyme deficiencies.
The molecular basis for the two different clinical presentations of classical pyruvate carboxylase deficiency.
The molecular basis of pyruvate carboxylase deficiency: mosaicism correlates with prolonged survival.
Treatment of pyruvate carboxylase deficiency with high doses of citrate and aspartate.
Triheptanoin for the treatment of brain energy deficit: A 14-year experience.
Unsuccessful treatment of severe pyruvate carboxylase deficiency with triheptanoin.
[3H]biotin-labeled proteins in cultured human skin fibroblasts from patients with pyruvate carboxylase deficiency.
[Neonatal lactic acidosis caused by severe pyruvate carboxylase deficiency]
[Pyruvate carboxylase deficiency]
[Suspected pyruvate carboxylase deficiency in 4 children with Leigh disease]
Pyruvate Carboxylase Deficiency Disease
A case of benign pyruvate carboxylase deficiency with normal development.
A case of pyruvate carboxylase deficiency with atypical clinical and neuroradiological presentation.
A case of pyruvate carboxylase deficiency with later prenatal diagnosis of an unaffected sibling.
A heuristic model for paradoxical effects of biotin starvation on carbon metabolism genes in the presence of abundant glucose.
A mutation of pyruvate carboxylase in fibroblasts from a patient with severe, chronic lactic acidaemia.
A Patient With Pyruvate Carboxylase Deficiency and Nemaline Rods on Muscle Biopsy.
A patient with pyruvate carboxylase deficiency in the liver: treatment with aspartic acid and thiamine.
A Unique Case of Pyruvate Carboxylase Deficiency.
Amerindian pyruvate carboxylase deficiency is associated with two distinct missense mutations.
An atypical French form of pyruvate carboxylase deficiency.
Antenatal manifestations of inborn errors of metabolism: autopsy findings suggestive of a metabolic disorder.
Biochemical and histologic pathology in an infant with cross-reacting material (negative) pyruvate carboxylase deficiency.
Brain amino acid abnormalities in pyruvate carboxylase deficiency.
Carrier detection of pyruvate carboxylase deficiency in fibroblasts and lymphocytes.
Case report of Takotsubo syndrome following seizures in a patient with pyruvate carboxylase deficiency.
Challenges in the management of an ignored cause of hyperammonemic encephalopathy: pyruvate carboxylase deficiency.
Comparative frequency and severity of hypoglycemia in selected organic acidemias, branched chain amino acidemia, and disorders of fructose metabolism.
Congenital lactic acidosis associated with pyruvate carboxylase deficiency.
Congenital lactic acidosis associated with pyruvate carboxylase deficiency. Repository identification No. GM6056.
Congenital lactic acidosis due to pyruvate carboxylase deficiency: absence of an inhibitor of TPP-ATP phosphoryl transferase.
Disorders of pyruvate carboxylase and the pyruvate dehydrogenase complex.
Disorders of pyruvate metabolism.
Evidence for two genetic complementation groups in pyruvate carboxylase-deficient human fibroblast cell lines.
Expression of pyruvate carboxylase in cultured oligodendroglial, microglial and ependymal cells.
Glycogen storage disease type I and III and pyruvate carboxylase deficiency: results of long-term treatment with uncooked cornstarch.
Hyperalaninemia hyperpyruvicemia and lactic acidosis due to pyruvate carboxylase deficiency of the liver; treatment with thiamine and lipoic acid.
Hyperalaninemia with pyruvicemia due to pyruvate carboxylase deficiency of the liver.
Increased prevalence of hereditary metabolic diseases among native Indians in Manitoba and northwestern Ontario.
Infantile parkinsonism and gabaergic hypotransmission in a patient with pyruvate carboxylase deficiency.
Intron retention and frameshift mutations result in severe pyruvate carboxylase deficiency in two male siblings.
Investigation of enzyme defects in children with lactic acidosis.
Ketogenic diet.
Ketogenic diet: an early option for epilepsy treatment, instead of a last choice only.
Lactic acidaemia.
Lactic acidosis due to pyruvate carboxylase deficiency.
Leigh's necrotizing encephalopathy with pyruvate carboxylase deficiency.
Lymphoblasts and diagnosis of pyruvate carboxylase deficiency.
Microdetermination of 2-ketoglutaric acid in plasma and cerebrospinal fluid by capillary gas chromatography mass spectrometry; application to pediatrics.
Mitochondrial Carbonic Anhydrase VA Deficiency Resulting from CA5A Alterations Presents with Hyperammonemia in Early Childhood.
Molecular characterization of pyruvate carboxylase deficiency in two consanguineous families.
MRI, clinical, and biochemical features of partial pyruvate carboxylase deficiency.
Neonatal congenital lactic acidosis with pyruvate carboxylase deficiency in two siblings.
Neonatal pyruvate carboxylase deficiency with renal tubular acidosis and cystinuria.
Novel Mutations in the PC Gene in Patients with Type B Pyruvate Carboxylase Deficiency.
Pathogenic mechanism, prophylaxis, and therapy of symptomatic acidosis induced by acetazolamide.
Plasma lysine concentration and availability of 2-ketoglutarate in liver mitochondria.
Prenatal diagnosis of pyruvate carboxylase deficiency by direct measurement of catalytic activity on chorionic villi samples.
Prenatal diagnosis of pyruvate carboxylase deficiency.
Prenatal onset of the neuroradiologic phenotype of pyruvate carboxylase deficiency due to homozygous PC c.1828G >?A mutations.
Prenatal sonographic description of fetuses affected by pyruvate dehydrogenase or pyruvate carboxylase deficiency.
Prolonged survival in pyruvate carboxylase deficiency: lack of correlation with enzyme activity in cultured fibroblasts.
Pyruvate carboxylase activity in subacute necrotizing encephalopathy (Leigh's disease).
Pyruvate carboxylase and phosphoenolpyruvate carboxykinase activity in leukocytes and fibroblasts from a patient with pyruvate carboxylase deficiency.
Pyruvate carboxylase defect: metabolic studies on cultured skin fibroblasts.
Pyruvate carboxylase deficiency and lactic acidosis in a retarded child without Leigh's disease.
Pyruvate carboxylase deficiency in pleiotropic carbohydrate-negative mutant strains of Pseudomonas aeruginosa.
Pyruvate carboxylase deficiency in twins.
Pyruvate carboxylase deficiency in yeast: a mutant affecting the interaction between the glyoxylate and Krebs cycles.
Pyruvate Carboxylase Deficiency Mimicking Diabetic Ketoacidosis.
Pyruvate carboxylase deficiency type A and type C: Characterization of five novel pathogenic variants in PC and analysis of the genotype-phenotype correlation.
Pyruvate carboxylase deficiency type C as a differential diagnosis of diabetic ketoacidosis.
Pyruvate Carboxylase Deficiency Type C: A Rare Cause of Acute Transient Flaccid Paralysis with Ketoacidosis.
Pyruvate carboxylase deficiency--insights from liver transplantation.
Pyruvate carboxylase deficiency.
Pyruvate carboxylase deficiency. Report of a case and additional evidence for the "mild" phenotype.
Pyruvate carboxylase deficiency: a benign variant with normal development.
Pyruvate carboxylase deficiency: acute exacerbation after ACTH treatment of infantile spasms.
Pyruvate carboxylase deficiency: an alleged biochemical cause of Leigh's disease.
Pyruvate carboxylase deficiency: An underestimated cause of lactic acidosis.
Pyruvate carboxylase deficiency: clinical and biochemical response to anaplerotic diet therapy.
Pyruvate carboxylase deficiency: mechanisms, mimics and anaplerosis.
Pyruvate carboxylase deficiency: metabolic characteristics and new neurological aspects.
Pyruvate carboxylase deficiency: prenatal onset of ischemia-like brain lesions in two sibs with the acute neonatal form.
Pyruvate carboxylase in the yeast pyc mutant.
Report of a patient with severe, chronic lactic acidaemia and pyruvate carboxylase deficiency.
Secondary citrullinemia with hyperammonemia in four neonatal cases of pyruvate carboxylase deficiency.
Some biochemical observations on biotin deficiency in the rat as a model for human pyruvate carboxylase deficiency.
Structural insights on pathogenic effects of novel mutations causing pyruvate carboxylase deficiency.
Studies on pyruvate carboxylase from cultured human fibroblasts and amniotic fluid cells.
Studies on pyruvate carboxylase, pyruvate decarboxylase and lipoamide dehydrogenase in subacute necrotizing encephalomyelopathy.
The clinical and biochemical implications of pyruvate carboxylase deficiency.
The French and North American phenotypes of pyruvate carboxylase deficiency, correlation with biotin containing protein by 3H-biotin incorporation, 35S-streptavidin labeling, and Northern blotting with a cloned cDNA probe.
The genetic heterogeneity of lactic acidosis: occurrence of recognizable inborn errors of metabolism in pediatric population with lactic acidosis.
The measurement of propionyl-CoA carboxylase and pyruvate carboxylase activity in hair roots: its use in the diagnosis of inherited biotin-dependent enzyme deficiencies.
The molecular basis for the two different clinical presentations of classical pyruvate carboxylase deficiency.
The molecular basis of pyruvate carboxylase deficiency: mosaicism correlates with prolonged survival.
Treatment of pyruvate carboxylase deficiency with high doses of citrate and aspartate.
Triheptanoin for the treatment of brain energy deficit: A 14-year experience.
Unsuccessful treatment of severe pyruvate carboxylase deficiency with triheptanoin.
[3H]biotin-labeled proteins in cultured human skin fibroblasts from patients with pyruvate carboxylase deficiency.
[Neonatal lactic acidosis caused by severe pyruvate carboxylase deficiency]
[Pyruvate carboxylase deficiency]
[Suspected pyruvate carboxylase deficiency in 4 children with Leigh disease]
pyruvate dehydrogenase (nadp+) deficiency
Antenatal manifestations of inborn errors of metabolism: autopsy findings suggestive of a metabolic disorder.
Prenatal sonographic description of fetuses affected by pyruvate dehydrogenase or pyruvate carboxylase deficiency.
Pyruvate Dehydrogenase Complex Deficiency Disease
Antenatal manifestations of inborn errors of metabolism: autopsy findings suggestive of a metabolic disorder.
Prenatal sonographic description of fetuses affected by pyruvate dehydrogenase or pyruvate carboxylase deficiency.
Reye Syndrome
Deficient activity of hepatic pyruvate dehydrogenase and pyruvate carboxylase in Reye's syndrome.
Rhinitis, Allergic
Inhibitory Effect of Pycnogenol
Sarcoma, Ewing
Characteristic increase in nucleocytoplasmic protein glycosylation by O-GlcNAc in 3T3-L1 adipocyte differentiation.
Seizures
Angiocentric glioma-associated seizures: The possible role of EATT2, pyruvate carboxylase and glutamine synthetase.
Case report of Takotsubo syndrome following seizures in a patient with pyruvate carboxylase deficiency.
Cerebral pyruvate carboxylase flux is unaltered during bicuculline-seizures.
Corrigendum to 'Angiocentric glioma-associated seizures: The possible role of EATT2, pyruvate carboxylase and glutamine synthetase [Seizure: European Journal of Epilepsy 86 (2021) 152-154].
Pyruvate carboxylase deficiency: acute exacerbation after ACTH treatment of infantile spasms.
Sepsis
Modulating Effects of Pycnogenol® on Oxidative Stress and DNA Damage Induced by Sepsis in Rats.
Spasms, Infantile
Pyruvate carboxylase deficiency: acute exacerbation after ACTH treatment of infantile spasms.
Spinal Cord Injuries
Pycnogenol achieves neuroprotective effects in rats with spinal cord injury by stabilizing the mitochondrial membrane potential.
Starvation
Effect of graded biotin levels in the diet on liver pyruvate carboxylase of chicks fed ad libitum and after starvation.
Effects of starvation, diabetes and carbon tetrachloride intoxication on rat kidney cortex and liver pyruvate carboxylase levels.
Inhibition of carbon dioxide fixation by lead acetate in rat liver mitochondria.
On the mechanism of gluconeogenesis and its regulation. 3. The glucogenic capacity and the activities of pyruvate carboxylase and PEP-carboxylase of rat kidney and rat liver after cortisol treatment and starvation.
Physiologic significance of glucocorticoids and insulin in the regulation of hepatic gluconeogenesis during starvation in rats.
[Effect of starvation, cortisol and insulin on the activities of pyruvate carboxylase, phosphopyruvate carboxylase (PEP-carboxykinase) and pyruvate kinase in the liver of NZo mice in various stages of diabetes]
Takotsubo Cardiomyopathy
Case report of Takotsubo syndrome following seizures in a patient with pyruvate carboxylase deficiency.
Thrombosis
Preparation of anticoagulant PyC biomaterials with super-hydrophobic surface.
Thyroid Cancer, Papillary
Corrigendum: Value of Pyruvate Carboxylase in Thyroid Fine-Needle Aspiration Wash-Out Fluid for Predicting Papillary Thyroid Cancer Lymph Node Metastasis.
Reprogramming of Energy Metabolism: Increased Expression and Roles of Pyruvate Carboxylase in Papillary Thyroid Cancer.
Value of Pyruvate Carboxylase in Thyroid Fine-Needle Aspiration Wash-Out Fluid for Predicting Papillary Thyroid Cancer Lymph Node Metastasis.
Thyroid Neoplasms
Pyruvate carboxylase promotes thyroid cancer aggressiveness through fatty acid synthesis.
transaldolase deficiency
Antenatal manifestations of inborn errors of metabolism: autopsy findings suggestive of a metabolic disorder.
Tuberculosis
Control of biotin biosynthesis in mycobacteria by a pyruvate carboxylase dependent metabolic signal.
Pyruvate carboxylase from Mycobacterium smegmatis: stabilization, rapid purification, molecular and biochemical characterization and regulation of the cellular level.
Uterine Cervical Neoplasms
An In Vitro Study on the Interactions of Pycnogenol® with Cisplatin in Human Cervical Cancer Cells.
Venous Insufficiency
A review of the French maritime pine bark extract (Pycnogenol), a herbal medication with a diverse clinical pharmacology.
Virus Diseases
Inhibition of hepatic phosphoenolpyruvate carboxykinase by avian reticuloendotheliosis viruses.
Yellow Fever
Biochemical, molecular, and phylogenetic analysis of pyruvate carboxylase in the yellow fever mosquito, Aedes aegypti.