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Information on EC 6.3.5.9 - hydrogenobyrinic acid a,c-diamide synthase (glutamine-hydrolysing)

for references in articles please use BRENDA:EC6.3.5.9
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IUBMB Comments
This enzyme, which participates in the aerobic (late cobalt insertion) cobalamin biosynthesis pathway, generates hydrogenobyrinate a,c-diamide, the substrate required by EC 6.6.1.2, cobaltochelatase, which adds cobalt to the macrocycle. The equivalent reaction in the anaerobic cobalamin biosynthesis pathway is catalysed by EC 6.3.5.11, cobyrinate a,c-diamide synthase.
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The expected taxonomic range for this enzyme is: Bacteria, Archaea, Eukaryota
Synonyms
CbiA, cobalamin biosynthesis aminotransferase, CobB, cobyric acid synthase, cobyrinic acid a,c-diamide synthase, new NaMN:Me2Bza phosphoribosyltransferase enzyme, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
2 ATP + hydrogenobyrinic acid + 2 L-glutamine + 2 H2O = 2 ADP + 2 phosphate + hydrogenobyrinic acid a,c-diamide + 2 L-glutamate
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This step in the aerobic biosynthesis of cobalamin generates hydrogenobyrinic acid a,c-diamide, the substrate required by EC 6.6.1.2, cobaltochelatase, which adds cobalt to the macrocycle
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