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Information on EC 6.3.5.4 - asparagine synthase (glutamine-hydrolysing) and Organism(s) Homo sapiens and UniProt Accession P08243
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6.3.5.4 asparagine synthase (glutamine-hydrolysing)IUBMB Comments
The enzyme from Escherichia coli has two active sites that are connected by an intramolecular ammonia tunnel [5,6]. The enzyme catalyses three distinct chemical reactions: glutamine hydrolysis to yield ammonia takes place in the N-terminal domain. The C-terminal active site mediates both the synthesis of a beta-aspartyl-AMP intermediate and its subsequent reaction with ammonia. The ammonia released is channeled to the other active site to yield asparagine .
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- 6.3.5.4
- leukemia
- lymphoblastic
- children
-
remission
- vincristine
- lymphoma
- methotrexate
- l-asparagine
- prednisone
- cyclophosphamide
- marrow
- erwinia
- daunorubicin
- doxorubicin
-
relapsed
- cr
- dexamethasone
-
consolidation
- thrombosis
-
l-aspartic
- chrysanthemi
- etoposide
-
pegylated
-
reinduction
- thromboembolism
- cytarabine
-
antileukemic
- glutaminase
-
intrathecal
-
prophylaxis
-
non-hodgkin
- ifosfamide
-
event-free
-
arabinoside
- antithrombin
- carotovora
- 6-mercaptopurine
-
extranodal
-
philadelphia
- agriculture
- lymphosarcoma
-
smile
- medicine
-
multiagent
-
myelosuppression
- hypofibrinogenemia
-
standard-risk
- pseudocysts
- nutrition
- teniposide
- drug development
- analysis
- daunomycin
- epipodophyllotoxins
- idarubicin
The taxonomic range for the selected organisms is: Homo sapiens
The enzyme appears in selected viruses and cellular organisms
The enzyme appears in selected viruses and cellular organisms
Reaction Schemes
Synonyms
l-asparaginase, asnase, asparagine synthetase b, glutamine-dependent asparagine synthetase, pvas2, taasn2, osas1, taasn1, glutamine-dependent amidotransferase, ste10, 
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
AS-B
-
-
-
-
AsnB
-
-
-
-
Asparagine synthetase
-
-
Asparagine synthetase (glutamine hydrolyzing)
-
-
-
-
Asparagine synthetase (glutamine)
-
-
-
-
Asparagine synthetase (glutamine-hydrolysing)
-
-
-
-
Asparagine synthetase B
-
-
-
-
Glutamine-dependent asparagine synthetase
-
-
-
-
L-Asparagine synthetase
-
-
-
-
Synthetase, Asn (glutamine)
-
-
-
-
TS11 cell cycle control protein
-
-
-
-
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
ATP + L-aspartate + L-glutamine + H2O = AMP + diphosphate + L-asparagine + L-glutamate
reaction mechanism, structure-function relationship
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PATHWAY SOURCE
PATHWAYS
-
-
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SYSTEMATIC NAME
IUBMB Comments
L-aspartate:L-glutamine amido-ligase (AMP-forming)
The enzyme from Escherichia coli has two active sites [4] that are connected by an intramolecular ammonia tunnel [5,6]. The enzyme catalyses three distinct chemical reactions: glutamine hydrolysis to yield ammonia takes place in the N-terminal domain. The C-terminal active site mediates both the synthesis of a beta-aspartyl-AMP intermediate and its subsequent reaction with ammonia. The ammonia released is channeled to the other active site to yield asparagine [6].
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CAS REGISTRY NUMBER
COMMENTARY
37318-72-2
-
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
ATP + L-aspartate + L-glutamine + H2O
AMP + diphosphate + L-asparagine + L-glutamate
-
-
-
?
ATP + L-aspartate + L-glutamine + H2O
AMP + diphosphate + L-asparagine + L-glutamate
-
-
-
-
?
ATP + L-Asp + L-Gln
AMP + diphosphate + Asn + Glu
-
-
-
-
?
ATP + L-Asp + L-Gln
AMP + diphosphate + Asn + Glu
-
the basic region leucine zipper protein ATF5, a transcriptional activator, stimulates asparagine promoter/reporter gene transcription via the nutrient-sensing response unit
-
-
?
ATP + L-Asp + L-Gln
AMP + diphosphate + Asn + Glu
-
resistance to L-asparaginase and relapse risk are associated with high expression of asparagine synthetase in TEL-AML1-negative but not in TEL-AML1-positive B-lineage acute lymphoblastic leukemia
-
-
?
ATP + L-aspartate + L-glutamine
AMP + diphosphate + L-asparagine + L-glutamate
-
-
-
?
ATP + L-aspartate + L-glutamine
AMP + diphosphate + L-asparagine + L-glutamate
-
-
-
?
additional information
?
-
-
upregulation of asparagine synthetase fails to avert cell cycle arrest induced by L-asparaginase in TEL/AML1-positive leukaemic cells
-
-
?
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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
ATP + L-aspartate + L-glutamine + H2O
AMP + diphosphate + L-asparagine + L-glutamate
-
-
-
?
ATP + L-Asp + L-Gln
AMP + diphosphate + Asn + Glu
-
the basic region leucine zipper protein ATF5, a transcriptional activator, stimulates asparagine promoter/reporter gene transcription via the nutrient-sensing response unit
-
-
?
ATP + L-aspartate + L-glutamine + H2O
AMP + diphosphate + L-asparagine + L-glutamate
-
-
-
-
?
additional information
?
-
-
upregulation of asparagine synthetase fails to avert cell cycle arrest induced by L-asparaginase in TEL/AML1-positive leukaemic cells
-
-
?
ATP + L-aspartate + L-glutamine
AMP + diphosphate + L-asparagine + L-glutamate
-
-
-
?
ATP + L-aspartate + L-glutamine
AMP + diphosphate + L-asparagine + L-glutamate
-
-
-
?
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COFACTOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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METALS and IONS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
6-diazo-5-oxo-L-norleucine
-
loss of Gln-dependent reactions, but no effect on ATP binding as measured during amminoa-dependent Asn synthesis
8-N3ATP
-
loss of NH4+-dependent Asn synthesis, but no effect on the glutaminase activity
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ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Acquired Immunodeficiency Syndrome
Glutaminase free l-asparaginase from Vibrio cholerae: Heterologous expression, purification and biochemical characterization.
Adenocarcinoma
Asparagine Synthetase Expression and Phase I Study With L-Asparaginase Encapsulated in Red Blood Cells in Patients With Pancreatic Adenocarcinoma.
Adenocarcinoma
Chemotherapy of the transplantable adenocarcinoma (R-3327) of the Copenhagen rat.
Adenocarcinoma
l-asparaginase induces intrinsic mitochondrial-mediated apoptosis in human gastric adenocarcinoma cells and impedes tumor progression.
Adenocarcinoma
Production, purification, characterization, antioxidant and antiproliferative activities of extracellular L-asparaginase produced by Fusarium equiseti AHMF4.
Afibrinogenemia
[Analysis of hypofibrinogenemias found on routine coagulation screening tests and identification of heterozygous dysfibrinogenemia or fibrinogen deficiency]
Anaphylaxis
Anaphylaxis to L-asparaginase during treatment for acute lymphoblastic leukemia in children--evidence of a complement-mediated mechanism.
Anaphylaxis
Correlation of L-asp Activity, Anti-L-asp Antibody, Asn and Gln With Adverse Events Especially Anaphylaxis Risks in PEG-asp-Contained Regime Treated Pediatric ALL Patients.
Anaphylaxis
Evaluation of L-asparaginase: polyethylene glycol conjugate versus native L-asparaginase combined with chemotherapy. A randomized double-blind study in canine lymphoma.
Anaphylaxis
Intravenous PEG-asparaginase during remission induction in children and adolescents with newly diagnosed acute lymphoblastic leukemia.
Anaphylaxis
Isolation and screening of L-asparaginase free of glutaminase and urease from fungal sp.
Anaphylaxis
Polyethylene glycol-L-asparaginase versus native L-asparaginase in canine non-Hodgkin's lymphoma.
Anaphylaxis
Solid-State Fermentation vs Submerged Fermentation for the Production of l-Asparaginase.
Anaphylaxis
Successful treatment with Erwinia L-asparaginase for recurrent natural killer/T cell lymphoma.
Anaphylaxis
Therapy with Erwinia L-asparaginase in children with acute leukemia after anaphylaxis to E. coli L-asparaginase.
Anaphylaxis
[Clinical experiences with adrenaline as therapy and prevention of E. coli-L-asparaginase-induced anaphylaxis]
Anaphylaxis
[Clinical experiences with polyethylene glycol-bound E. coli L-asparaginase in patients with multiple recurrences of acute lymphoblastic leukemia]
Anaphylaxis
[Formation of specific IgG antibodies in l-asparaginase treatment. Distribution of IgG subclasses]
Anemia, Aplastic
Concurrent Epstein-Barr virus associated NK/T cell lymphoma after immunosuppressive therapy for aplastic anemia: report of a case and review of literature.
Anemia, Hemolytic
L-asparaginase effect on the erythrocyte-immunoglobulin binding in acquired hemolytic anemia.
Anemia, Hemolytic
The L-asparaginase effect on the erythrocyte survival time in patients with acquired hemolytic anemia of the IgG and IgA type.
Anemia, Hemolytic
[Letter: Attempt at dissociation of immunoglobulins from the erythrocytic surface of a patient with hemolytic anemia caused by L-asparaginase in vitro experiment (author's transl)]
Antithrombin III Deficiency
Fatal pulmonary embolism and antithrombin III deficiency in adult lymphoblastic leukaemia during L-asparaginase therapy.
Antithrombin III Deficiency
L-asparaginase induced antithrombin III deficiency: evidence against the production of a hypercoagulable state.
Antithrombin III Deficiency
[L-asparaginase, antithrombin III deficiency and thromboses (author's transl)]
Antithrombin III Deficiency
[Monitoring therapy with L-asparaginase. Model of drug-induced antithrombin III deficiency]
Aphasia
Cerebrovascular complications of L-asparaginase therapy in children with leukemia: aphasia and other neuropsychological deficits.
Arthritis, Experimental
Biochemical criteria for the evaluation of drug efficiency on adjuvant arthritis and nephrotoxic serum nephritis in the rat: studies with phenylbutazone, L-Asparaginase, colchicine, lysine acetylsalicylate, and pyridinol carbamate.
Arthritis, Experimental
Treatment of collagen induced arthritis in DBA/1 mice with L-asparaginase.
Arthritis, Rheumatoid
Treatment of collagen induced arthritis in DBA/1 mice with L-asparaginase.
Arthus Reaction
Acrylic microspheres in vivo V: Immunological properties of immobilized asparaginase in microparticles.
Blast Crisis
Idarubicin in the initial treatment of adults with acute lymphoblastic leukemia: the effect of drug schedule on outcome.
Blast Crisis
Very long survival in complete cytogenetic remission in an adolescent with lymphoid blast crisis of chronic myeloid leukemia after treatment with intensive ALL-directed chemotherapy combined with continuous imatinib.
Brain Diseases
Acute central nervous system complications and ammonium levels in adult patients with acute lymphoblastic leukemia receiving l-asparaginase.
Brain Diseases
Iatrogenic Coagulopathy and the Development of Posterior Reversible Encephalopathy Syndrome after L-asparaginase Chemotherapy.
Brain Diseases
L-asparaginase-induced posterior reversible encephalopathy syndrome during acute lymphoblastic leukemia treatment in children.
Brain Edema
Multiple Severe Toxicities of L-Asparaginase and Their Innovative Management during Induction Therapy of Acute Lymphoblastic Leukemia in an Adult Patient.
Breast Neoplasms
Antiproliferative activity of L-asparaginase of Tetrahymena pyriformis on human breast cancer cell lines.
Breast Neoplasms
Chemoimmunotherapy for metastatic breast cancer with 5-fluorouracil, adriamycin, cyclophosphamide, methotrexate, L-asparaginase, Corynebacterium parvum, and Pseudomonas vaccine.
Breast Neoplasms
Clinical characteristics of Japanese patients with severe hypertriglyceridemia.
Breast Neoplasms
Phase II study with sequential L-asparaginase and methotrexate in advanced refractory breast cancer.
Breast Neoplasms
Purification and biotechnological applications of L-asparaginase from newly isolated Bacillus halotolerans OHEM18 as antitumor and antioxidant agent.
Breast Neoplasms
Yarrowia lipolytica L-asparaginase inhibits the growth and migration of lung (A549) and breast (MCF7) cancer cells.
Burkitt Lymphoma
Safety of Eicosapentaenoic Acid in Cancer Treatment: Effect on Cancer Cells and Chemotherapy in Vitro.
Burkitt Lymphoma
The effect of Yarrowia lipolytical-asparaginase on apoptosis induction and inhibition of growth in Burkitt's lymphoma Raji and acute lymphoblastic leukemia MOLT-4 cells.
Carcinogenesis
Studies on inhibition of viral oncogenesis. II. Inhibitory effect of L-asparaginase, clam liver extract and methotrexate on rous sarcoma virus focus formation.
Carcinoma
Bioprocess development for L-asparaginase production by Streptomyces rochei, purification and in-vitro efficacy against various human carcinoma cell lines.
Carcinoma
Molecular and genetic characterization of human cell lines resistant to L-asparaginase and albizziin.
Carcinoma
Production, purification, characterization, antioxidant and antiproliferative activities of extracellular L-asparaginase produced by Fusarium equiseti AHMF4.
Carcinoma
Prolonged control of hypoglycaemia by L-asparaginase in islet cell carcinoma producing insulin and gastrin.
Carcinoma
Sensitivity of cultured pancreatic carcinoma cells to Acinetobacter glutaminase-asparaginase.
Carcinoma, Bronchogenic
An analysis of comparative trails of L-asparaginase (NSC-109929), cyclophosphamide and placebo in patients with inoperable bronchogenic carcinoma using corrected survival estimates.
Carcinoma, Ehrlich Tumor
Design of expert guided investigation of native L-asparaginase encapsulated long-acting cross-linker-free poly (lactic-co-glycolic) acid nanoformulation in an Ehrlich ascites tumor model.
Carcinoma, Hepatocellular
Comparison of antitumor effect of recombinant L-asparaginase with wild type one in vitro and in vivo.
Carcinoma, Hepatocellular
Effect of the antileukemic agent L-asparaginase on thyroxine-binding globulin and albumin synthesis in cultured human hepatoma (HEP G2) cells.
Carcinoma, Hepatocellular
L-Asparaginase and Inhibitors of Glutamine Synthetase Disclose Glutamine Addiction of ?-Catenin-Mutated Human Hepatocellular Carcinoma Cells.
Carcinoma, Hepatocellular
Production, purification, characterization, antioxidant and antiproliferative activities of extracellular L-asparaginase produced by Fusarium equiseti AHMF4.
Carcinoma, Hepatocellular
Purification and biotechnological applications of L-asparaginase from newly isolated Bacillus halotolerans OHEM18 as antitumor and antioxidant agent.
Carcinoma, Hepatocellular
The synergistic effect of hypoglycemia and L-asparaginase upon transplantable hepatomas of varying growth rates.
Carcinoma, Islet Cell
Prolonged control of hypoglycaemia by L-asparaginase in islet cell carcinoma producing insulin and gastrin.
Carcinosarcoma
[Results of an experimental study of the antitumor activity of 1-asparaginase from E. coli and Erw. carotovora]
Cerebral Hemorrhage
[Fatal central nervous system hemorrhage during acute lymphoblastic leukemia induction].
Cerebral Infarction
Cerebral infarction in a patient with acute lymphoblastic leukemia after fresh-frozen plasma replacement during L-asparaginase therapy.
Chickenpox
Concomitant Use of Acyclovir and Intravenous Immunoglobulin Rescues an Immunocompromised Child With Disseminated Varicella Caused Multiple Organ Failure.
Cholestasis
Hepatomegaly and fever at the time of neutrophil recovery revealing L-asparaginase toxicity in the treatment of acute lymphoblastic leukemia.
Colorectal Neoplasms
Production, purification, characterization, antioxidant and antiproliferative activities of extracellular L-asparaginase produced by Fusarium equiseti AHMF4.
Coma
Multiple Severe Toxicities of L-Asparaginase and Their Innovative Management during Induction Therapy of Acute Lymphoblastic Leukemia in an Adult Patient.
Communicable Diseases
Hepatomegaly and fever at the time of neutrophil recovery revealing L-asparaginase toxicity in the treatment of acute lymphoblastic leukemia.
Communicable Diseases
The morpheein model of allosterism: a remedial step for targeting virulent l-asparaginase.
Confusion
L-asparaginase fatal toxic encephalopathy during consolidation treatment in an adult with acute lymphoblastic leukemia.
Conjunctivitis
Toxicity of sequential high-dose ARA-C asparaginase treatment in childhood poor risk leukemia.
Coronary Thrombosis
[Distal coronary thrombosis during l-asparaginase treatment for an acute lymbloblastic leukaemia.]
Diabetes Mellitus
Diabetes mellitus and pancreatitis as a complication of L-asparaginase therapy.
Diabetes Mellitus
L-Asparaginase diabetes mellitus in rabbits: differing effects of two different schedules of L-asparaginase administration.
Diabetes Mellitus
Relative hyperglucagonemia in L-asparaginase-and prednisone-induced glucose intolerance in management of acute lymphocytic leukemia.
Diabetes Mellitus
The prevalence and etiology of extreme hypertriglyceridemia in children: Data from a tertiary children's hospital.
Diabetes Mellitus
Transient diabetes mellitus secondary to L-asparaginase therapy in acute leukemia.
Diabetes Mellitus
[Transient diabetes mellitus induced by L-asparaginase in a patient with acute myeloblastic leukemia (author's transl)]
Diabetes Mellitus
[Transient diabetes mellitus with ketoacidosis in a child during the treatment of acute lymphoblastic leukemia with L-asparaginase]
Diabetic Ketoacidosis
Acute Pancreatitis and Diabetic Ketoacidosis following L-Asparaginase/Prednisone Therapy in Acute Lymphoblastic Leukemia.
Diabetic Ketoacidosis
Concurrent diabetic ketoacidosis and pancreatitis in Paediatric acute lymphoblastic leukemia receiving L-asparaginase.
Diabetic Ketoacidosis
Diabetic ketoacidosis and persistent hyperglycemia as long-term complications of L-asparaginase-induced pancreatitis.
Diabetic Ketoacidosis
Diabetic ketoacidosis secondary to L-asparaginase in acute lymphoblastic leukaemia.
Diabetic Ketoacidosis
Hyperglycemia induced by chemotherapeutic agents used in acute lymphoblastic leukemia: report of three cases.
Diabetic Ketoacidosis
Study of beta-cell function and erythrocyte insulin receptors in a patient with diabetic ketoacidosis associated with L-asparaginase therapy.
Diabetic Ketoacidosis
[Diabetic ketoacidosis and hypofibrinogenemia as a complication of the treatment with L-asparaginase of acute lymphoblastic leukemia]
Disseminated Intravascular Coagulation
Use of a synthetic protease inhibitor for the treatment of L-asparaginase-induced acute pancreatitis complicated by disseminated intravascular coagulation.
Disseminated Intravascular Coagulation
[MRI abnormalities of the brain in neurologic complications following treatment of cancer in children]
Disseminated Intravascular Coagulation
[Superior sagittal sinus thrombosis after intrathecal chemotherapy and intravenous high-dose cytarabine in an acute myeloid leukemia case with t(8;21)(q22;q22)].
Encephalomyelitis, Autoimmune, Experimental
Further studies on the inhibition of allergic encephalomyelitis by L-asparaginase.
Encephalomyelitis, Autoimmune, Experimental
L-asparaginase in experimental auto-immune disease: inhibition of allergic encephalomyelitis.
Endocarditis
Staphylococcal endocarditis presenting with a renal infarct in a patient with acute lymphoblastic leukemia.
Endometrial Neoplasms
Loss of ASRGL1 expression is an independent biomarker for disease-specific survival in endometrioid endometrial carcinoma.
Enterocolitis, Neutropenic
[Surgery for neutropenic enterocolitis, a complication in acute lymphoblastic leukemia]
Enzootic Bovine Leukosis
[In vitro studies using E. coli L-asparaginase on lymphatic cells of bovine leukemia and various transplantation tumors]
Exanthema
An experience with plasma exhcange treatment of acute lymphoblastic leukemia in a case with fulminant hepatitis related to l-asparaginase.
Fatty Liver
Hepatomegaly and fever at the time of neutrophil recovery revealing L-asparaginase toxicity in the treatment of acute lymphoblastic leukemia.
Febrile Neutropenia
L-Asparaginase lowers plasma antithrombin and mannan-binding-lectin levels: Impact on thrombotic and infectious events in children with acute lymphoblastic leukemia.
Fibrosarcoma
Antitumor activity of L-asparaginase from Cylindrocarpon obtusisporum MB-10 and its effect on the immune system.
Fibrosarcoma
Molecular and genetic characterization of human cell lines resistant to L-asparaginase and albizziin.
Glioblastoma
Asparagine Depletion Potentiates the Cytotoxic Effect of Chemotherapy Against Brain Tumors.
Glioblastoma
L-asparaginase and 6-diazo-5-oxo-L-norleucine synergistically inhibit the growth of glioblastoma cells.
Glioblastoma
Metabolic reprogramming of glioblastoma cells by L-asparaginase sensitizes for apoptosis in vitro and in vivo.
Glioma
Hypersensitivity of rat glioma sublines with acquired ACNU resistance to L-asparaginase.
Glioma
Metabolic reprogramming of glioblastoma cells by L-asparaginase sensitizes for apoptosis in vitro and in vivo.
Glycosuria
[Acute pancreatitis in children with acute lymphoblastic leukemia treated with L-asparaginase]
Heart Failure
Risk factors for the development of hospital-acquired pediatric venous thromboembolism-Dealing with potentially causal and confounding risk factors using a directed acyclic graph (DAG) analysis.
Hematologic Diseases
Differences in the blast cells sensitivity to cytostatic drugs in various acute leukemia types and their clinical implications.
Hematologic Neoplasms
Diabetic ketoacidosis and persistent hyperglycemia as long-term complications of L-asparaginase-induced pancreatitis.
Hematologic Neoplasms
High efficacy of monomethoxypolyethylene glycol-conjugated L-asparaginase (PEG2-ASP) in two patients with hematological malignancies.
Hematologic Neoplasms
[Superior sagittal sinus thrombosis during remission induction therapy for acute lymphoblastic leukemia]
Hemianopsia
[Homonymous lateral hemianopsia revealing cerebral thrombophlebitis. Role of a deficiency of protein S induced by l-asparaginase]
Hemorrhoids
[Recurrent thrombosed external hemorrhoids due to L-asparaginase administration in a Philadelphia chromosome-positive acute lymphoblastic leukemia patient].
Hemostatic Disorders
[Hemostatic disorders in the treatment of leukoblastosis with L-asparaginase (crasnitin)]
Hepatic Encephalopathy
Multiple Severe Toxicities of L-Asparaginase and Their Innovative Management during Induction Therapy of Acute Lymphoblastic Leukemia in an Adult Patient.
Hepatitis
[Fulminant hepatitis possibly caused by L-asparaginase during induction chemotherapy in a patient with acute lymphoblastic leukemia].
Hepatomegaly
Hepatomegaly and fever at the time of neutrophil recovery revealing L-asparaginase toxicity in the treatment of acute lymphoblastic leukemia.
Histiocytosis, Langerhans-Cell
A desensitization protocol in children with L-asparaginase hypersensitivity.
Hodgkin Disease
Outcomes of treatment of children and adolescents with recurrent non-Hodgkin's lymphoma and Hodgkin's disease with dexamethasone, etoposide, cisplatin, cytarabine, and l-asparaginase, maintenance chemotherapy, and transplantation: Children's Cancer Group Study CCG-5912.
Hypercholesterolemia
Hypertriglyceridemia and hypercholesterolemia induced by L-asparaginase.
Hyperglycemia
An open-label, multicenter study of polyethylene glycol-L-asparaginase for the treatment of acute lymphoblastic leukemia.
Hyperglycemia
Concurrent diabetic ketoacidosis and pancreatitis in Paediatric acute lymphoblastic leukemia receiving L-asparaginase.
Hyperglycemia
Endocrine complications in pediatric patients with acute lymphoblastic leukemia.
Hyperglycemia
Evaluation of dose and schedule of L-asparaginase in multidrug therapy of childhood leukemia.
Hyperglycemia
Hyperglycemia associated with the therapeutic use of L-asparaginase: possible role of insulin receptors.
Hyperglycemia
Hyperglycemia induced by chemotherapeutic agents used in acute lymphoblastic leukemia: report of three cases.
Hyperglycemia
Hyperglycemia, ketoacidosis and other complications of L-asparaginase in children with acute lymphoblastic leukemia.
Hyperglycemia
Incidence of Hyperglycemia during Induction of Remission Phase of Pediatric Acute Lymphoblastic Leukemia.
Hyperglycemia
L-Asparaginase in the treatment of refractory and relapsed extranodal NK/T-cell lymphoma, nasal type.
Hyperglycemia
Methotrexate plus L-asparaginase. An active combination for children with acute nonlymphocytic leukemia.
Hyperglycemia
Nonketotic hyperglycemia due to prednisone (NSC-10023) following ketotic hyperglycemia due to L-asparaginase (NSC-109229) plus prednisone.
Hyperglycemia
Protracted Administration of L-Asparaginase in Maintenance Phase Is the Risk Factor for Hyperglycemia in Older Patients with Pediatric Acute Lymphoblastic Leukemia.
Hyperglycemia
Relative hyperglucagonemia in L-asparaginase-and prednisone-induced glucose intolerance in management of acute lymphocytic leukemia.
Hyperglycemia
Risk factors for hyperglycemia in children with leukemia receiving L-asparaginase and prednisone.
Hyperglycemia
The Effect of Combination of Steroid and L-Asparaginase on Hyperglycemia in Children with Acute Lymphoblastic Leukemia (ALL).
Hyperglycemia
Unexpected mortality from the use of E. coli L-asparaginase during remission induction therapy for childhood acute lymphoblastic leukemia: a report from the Taiwan Pediatric Oncology Group.
Hyperglycemia
[Hyperglycemia as a side effect of using L-asparaginase in children with acute lymphoblastic leukemia (ALL]
Hyperlipidemias
Factors with conformational effects on haemostatic serpins: implications in thrombosis.
Hyperlipidemias
Severe hyperlipidemia in a child with acute lymphoblastic leukemia treated with L-asparaginase and prednisone.
Hyperlipidemias
Transient hyperlipidemia during treatment of ALL with L-asparaginase is related to decreased lipoprotein lipase activity.
Hyperlipidemias
[Iatrogenic hyperlipidemia after l-asparaginase and glucocorticoid treatment in two children with acute lymphoblastic leukemia]
Hyperlipidemias
[L-asparaginase-induced hyperlipidemia in a case of acute lymphoblastic leukemia]
Hypersensitivity
A comprehensive review on microbial l-asparaginase: Bioprocessing, characterization, and industrial applications.
Hypersensitivity
A critical review on properties and applications of microbial l-asparaginases.
Hypersensitivity
A desensitization protocol in children with L-asparaginase hypersensitivity.
Hypersensitivity
A dyad of lymphoblastic lysosomal cysteine proteases degrades the antileukemic drug L-asparaginase.
Hypersensitivity
A five-year retrospective study of treatment outcomes using the L-asparaginase-based regimen as a first-line chemotherapy protocol for patients diagnosed with extranodal NK/T-cell lymphoma, nasal-type, in Thailand.
Hypersensitivity
Adverse events to nontargeted and targeted chemotherapeutic agents: emphasis on hypersensitivity responses.
Hypersensitivity
Allergic reactions and antiasparaginase antibodies in children with high-risk acute lymphoblastic leukemia: A children's oncology group report.
Hypersensitivity
Allergic reactions to asparaginase: Retrospective cohort study in pediatric patients with acute lymphoid leukemia.
Hypersensitivity
Allergic reactions to E. coli L-asparaginase do not affect outcome in childhood B-precursor acute lymphoblastic leukemia: a Children's Oncology Group Study.
Hypersensitivity
Alternative algorithm for L-asparaginase allergy in children with acute lymphoblastic leukemia.
Hypersensitivity
An experience with plasma exhcange treatment of acute lymphoblastic leukemia in a case with fulminant hepatitis related to l-asparaginase.
Hypersensitivity
An open-label, multicenter study of polyethylene glycol-L-asparaginase for the treatment of acute lymphoblastic leukemia.
Hypersensitivity
An urchin-like helical polypeptide-asparaginase conjugate with mitigated immunogenicity.
Hypersensitivity
Anaphylactic reaction to polyethylene-glycol conjugated-asparaginase: premedication and desensitization may not be sufficient.
Hypersensitivity
Asparaginase immune complexes induce Fc-?RIII-dependent hypersensitivity in naive mice.
Hypersensitivity
Augmented Berlin-Frankfurt-Munster therapy abrogates the adverse prognostic significance of slow early response to induction chemotherapy for children and adolescents with acute lymphoblastic leukemia and unfavorable presenting features: a report from the Children's Cancer Group.
Hypersensitivity
Can recombinant technology address asparaginase Erwinia chrysanthemi shortages?
Hypersensitivity
Comparative immunogenicity and structural analysis of epitopes of different bacterial L-asparaginases.
Hypersensitivity
Delayed-type hypersensitivity in response to L-asparaginase in a case of acute lymphoblastic leukemia.
Hypersensitivity
Development of anti-asparaginase antibodies in childhood acute lymphoblastic leukemia.
Hypersensitivity
Development of asparaginase Erwinia chrysanthemi for the treatment of acute lymphoblastic leukemia.
Hypersensitivity
Drug monitoring of PEG-asparaginase treatment in childhood acute lymphoblastic leukemia and non-Hodgkin's lymphoma.
Hypersensitivity
Evaluation of dose and schedule of L-asparaginase in multidrug therapy of childhood leukemia.
Hypersensitivity
Evaluation of L-asparaginase: polyethylene glycol conjugate versus native L-asparaginase combined with chemotherapy. A randomized double-blind study in canine lymphoma.
Hypersensitivity
Expression of CD203c on basophils as a marker of immunoglobulin E-mediated l-asparaginase allergy.
Hypersensitivity
Genetic inhibition of NFATC2 attenuates asparaginase hypersensitivity in mice.
Hypersensitivity
Hypersensitivity of rat glioma sublines with acquired ACNU resistance to L-asparaginase.
Hypersensitivity
Hypersensitivity reactions associated with L-asparaginase administration in 142 dogs and 68 cats with lymphoid malignancies: 2007-2012.
Hypersensitivity
Hypersensitivity reactions to L-asparaginase do not impact on the remission duration of adults with acute lymphoblastic leukemia.
Hypersensitivity
Impact of Asparaginase Discontinuation on Outcome in Childhood Acute Lymphoblastic Leukemia: A Report From the Children's Oncology Group.
Hypersensitivity
Implementation of the asparaginase activity assessment technique for clinical use: experience of a Brazilian Center.
Hypersensitivity
Improved pharmacokinetic and pharmacodynamic profile of a novel PEGylated native Erwinia chrysanthemi L-Asparaginase.
Hypersensitivity
Improved survival of children with isolated CNS relapse of acute lymphoblastic leukemia: a pediatric oncology group study .
Hypersensitivity
Incidence and Management of Toxicity Associated with LAsparaginase in the Treatment of ALL and NK/TCell Lymphoma: an Observational Study.
Hypersensitivity
Influence of lysosomal protease sensitivity in the immunogenicity of the antitumor biopharmaceutical asparaginase.
Hypersensitivity
L-Asparaginase and Steroids-associated Hypertriglyceridemia Successfully Treated With Plasmapheresis in a Child With Acute Lymphoblastic Leukemia.
Hypersensitivity
L-Asparaginase in the treatment of refractory and relapsed extranodal NK/T-cell lymphoma, nasal type.
Hypersensitivity
L-asparaginase used with cytosine arabinoside in treatment of childhood acute lymphocytic leukemia refractory to vincristine and prednisone.
Hypersensitivity
L-asparaginase-Based induction therapy for advanced extranodal NK/T-cell lymphoma.
Hypersensitivity
l-asparaginase: an effective agent in the treatment of acute lymphoblastic leukemia.
Hypersensitivity
Measurement of subvisible particulates in lyophilised Erwinia chrysanthemi L-asparaginase and relationship with clinical experience.
Hypersensitivity
Methotrexate plus L-asparaginase. An active combination for children with acute nonlymphocytic leukemia.
Hypersensitivity
Monitoring of Anti-L-Asparaginase Antibody and L-Asparaginase Activity Levels in a Pediatric Patient With Acute Lymphoblastic Leukemia and Hypersensitivity to Native Escherichia coli L-Asparaginase During Desensitization Courses.
Hypersensitivity
Monolith and coating enzymatic microreactors of l-asparaginase: kinetics study by MCE-LIF for potential application in acute lymphoblastic leukemia (ALL) treatment.
Hypersensitivity
Nonclassic functions of human topoisomerase I: genome-wide and pharmacologic analyses.
Hypersensitivity
Outcomes Following Discontinuation of E. coli l-Asparaginase Upon Severe Allergic Reactions in Children With Acute Lymphoblastic Leukemia.
Hypersensitivity
PEG-asparaginase allergy in children with acute lymphoblastic leukemia in the NOPHO ALL2008 protocol.
Hypersensitivity
PEG-asparaginase in BFM-90 regimen improves outcomes in adults with newly diagnosed lymphoblastic lymphoma.
Hypersensitivity
Pegasparaginase silent inactivation during therapy for NK/T cell lymphoma.
Hypersensitivity
Pegaspargase versus asparaginase in adult ALL: a pharmacoeconomic assessment.
Hypersensitivity
Pharmacological and clinical evaluation of L-asparaginase in the treatment of leukemia.
Hypersensitivity
Pharmacology, immunogenicity, and efficacy of a novel pegylated recombinant Erwinia chrysanthemi-derived L-asparaginase.
Hypersensitivity
Polyethylene Glycol-conjugated L-asparaginase versus native L-asparaginase in combination with standard agents for children with acute lymphoblastic leukemia in second bone marrow relapse: a Children's Oncology Group Study (POG 8866).
Hypersensitivity
Polymorphisms in GRIA1 gene are a risk factor for asparaginase hypersensitivity during the treatment of childhood ALL.
Hypersensitivity
Prolonged second remissions in childhood acute lymphocytic leukemia: a report from the Childrens Cancer Study Group.
Hypersensitivity
Prospective, real-time monitoring of pegylated Escherichia coli and Erwinia asparaginase therapy in childhood acute lymphoblastic leukaemia and non-Hodgkin lymphoma in Belgium.
Hypersensitivity
Review of pharmacogenetics studies of L-asparaginase hypersensitivity in acute lymphoblastic leukemia points to variants in the GRIA1 gene.
Hypersensitivity
Screening and characterization of extracelluar L-asparaginase producing Bacillus subtilis strain hswx88, isolated from Taptapani hotspring of Odisha, India.
Hypersensitivity
Screening and optimizing fermentation production of L-asparaginase by Aspergillus terreus strain S-18 isolated from the Brazilian Caatinga Biome.
Hypersensitivity
Suppression of skin hypersensitivity and antibody formation by L-asparaginase.
Hypersensitivity
The complex clinical picture of presumably allergic side effects to cytostatic drugs: symptoms, pathomechanism, reexposure, and desensitization.
Hypersensitivity
The feasibility of Erwinia asparaginase for pediatric patients who developed an allergic reaction to E.coli asparaginase during treatment of acute lymphoblastic leukemia.
Hypersensitivity
The Incidence of Hypersensitivity Reactions to Pegylated Asparaginase in Children With Acute Lymphoblastic Leukemia: A City-wide Experience.
Hypersensitivity
Toxicity of sequential high-dose ARA-C asparaginase treatment in childhood poor risk leukemia.
Hypersensitivity
Whole-exome sequencing identified genetic risk factors for asparaginase-related complications in childhood ALL patients.
Hypersensitivity
[Allergic complications of L-asparaginase therapy in children with acute lymphoblastic leukaemia].
Hypersensitivity
[Allergic reactions and antibody formation in children and adults treated with L-asparaginase for leukemia]
Hypersensitivity
[Allergic reactions in treatment with L-asparaginase. Significance of specific IgE antibodies]
Hypersensitivity
[Significance of L-asparaginase activity and biochemical parameters evaluation in children with acute lymphoblastic leukemia]
Hypersensitivity, Immediate
Atopic hypersensitivity to L-asparaginase. Resistance to immunosuppression.
Hyperthyroidism
Transient hyperthyroidism following L-asparaginase therapy for acute lymphoblastic leukemia.
Hypertriglyceridemia
Acarbose is an effective treatment for severe hypertriglyceridemia secondary to l-asparaginase and dexamethasone.
Hypertriglyceridemia
Asparaginase formulation impacts hypertriglyceridemia during therapy for acute lymphoblastic leukemia.
Hypertriglyceridemia
Asparaginase-associated pancreatitis is not predicted by hypertriglyceridemia or pancreatic enzyme levels in children with acute lymphoblastic leukemia.
Hypertriglyceridemia
Characterization of hypertriglyceridemia induced by L-asparaginase therapy for acute lymphoblastic leukemia and malignant lymphoma.
Hypertriglyceridemia
Clinical characteristics of Japanese patients with severe hypertriglyceridemia.
Hypertriglyceridemia
Conservative management of L-asparaginase-induced hypertriglyceridemia in an adult patient: a case report and review of the literature.
Hypertriglyceridemia
Hypertriglyceridemia and hypercholesterolemia induced by L-asparaginase.
Hypertriglyceridemia
L-Asparaginase and Steroids-associated Hypertriglyceridemia Successfully Treated With Plasmapheresis in a Child With Acute Lymphoblastic Leukemia.
Hypertriglyceridemia
L-asparaginase induced severe hypertriglyceridemia in acute lymphoblastic leukemia with 11q23 abnormality.
Hypertriglyceridemia
Management of hypertriglyceridemia in children with acute lymphoblastic leukemia under persistent therapy with glucocorticoids and L-asparaginase during induction chemotherapy.
Hypertriglyceridemia
[Hypertriglyceridemia, Discorvered on a Pseudohyponatremia, Induced by L-asparaginase in the Treatment of B Acute Lymphoblastic Leukemia in Child].
Hypertriglyceridemia
[Iatrogenic hyperlipidemia after l-asparaginase and glucocorticoid treatment in two children with acute lymphoblastic leukemia]
Hypertriglyceridemia
[Successful readministration of L-asparaginase after development of severe hypertriglyceridemia in a young adult with T-cell acute lymphoblastic leukemia].
Hypoalbuminemia
Differences in teniposide disposition and pharmacodynamics in patients with newly diagnosed and relapsed acute lymphocytic leukemia.
Hypoalbuminemia
Unexpected mortality from the use of E. coli L-asparaginase during remission induction therapy for childhood acute lymphoblastic leukemia: a report from the Taiwan Pediatric Oncology Group.
Hypocalcemia
[Hypoparathyroidismus following L-asparaginase and vaccinia virus infection. Effect of hypocalcemia on phagocytosis and the function of lymphocytes]
Hypoglycemia
Control of hypoglycemia with L-asparaginase in a patient with islet cell cancer.
Hypoglycemia
Hypoglycemia associated with L-asparaginase in acute lymphoblastic leukemia treatment: a case report.
Hypoglycemia
L-asparaginase induced hypoglycemia in a case of acute lymphoblastic leukemia: a patient report.
Hypoglycemia
The synergistic effect of hypoglycemia and L-asparaginase upon transplantable hepatomas of varying growth rates.
Hypoparathyroidism
[Hypoparathyroidism following application of L-asparaginase in the rabbit]
Hypoparathyroidism
[Hypoparathyroidismus following L-asparaginase and vaccinia virus infection. Effect of hypocalcemia on phagocytosis and the function of lymphocytes]
Hypoprothrombinemias
Fibrinopeptide A changes during remission induction treatment with L-asparaginase in acute lymphoblastic leukemia: evidence for activation of blood coagulation.
Hypothyroidism
Clinical characteristics of Japanese patients with severe hypertriglyceridemia.
Hypothyroidism
Transient secondary hypothyroidism and thyroxine binding globulin deficiency in leukemic children during polychemotherapy: an effect of L-asparaginase.
Infections
Helicobacter pylori L-asparaginase: A Novel Bacterial Antigen that May Contribute to Infection Detection.
Infections
Pepper asparagine synthetase 1 (CaAS1) is required for plant nitrogen assimilation and defense responses to microbial pathogens.
Infections
Risk factors for the development of hospital-acquired pediatric venous thromboembolism-Dealing with potentially causal and confounding risk factors using a directed acyclic graph (DAG) analysis.
Infections
Unexpected mortality from the use of E. coli L-asparaginase during remission induction therapy for childhood acute lymphoblastic leukemia: a report from the Taiwan Pediatric Oncology Group.
Infections
[Superior sagittal sinus thrombosis during remission induction therapy for acute lymphoblastic leukemia]
Intracranial Hemorrhages
Intracranial hemorrhage and focal seizures secondary to use of L-asparaginase during induction therapy of acute lymphocytic leukemia.
Intracranial Thrombosis
Cerebrovascular complications of L-asparaginase therapy in children with leukemia: aphasia and other neuropsychological deficits.
Intracranial Thrombosis
Childhood non-Hodgkin's lymphoma--results of treatment with ALL high-risk protocol.
Intracranial Thrombosis
Neurosurgical management of L-asparaginase induced haemorrhagic stroke.
Intracranial Thrombosis
Osteonecrosis of vertebrae in a child with acute lymphocytic leukaemia during L-asparaginase therapy.
Intracranial Thrombosis
[Cerebral thrombosis in a child with acute lymphocytic leukemia during L-asparaginase therapy]
Intracranial Thrombosis
[Homonymous lateral hemianopsia revealing cerebral thrombophlebitis. Role of a deficiency of protein S induced by l-asparaginase]
Intracranial Thrombosis
[Neurologic complications during chemotherapy of children with acute lymphoid leukemia]
Ischemic Attack, Transient
Sagittal sinus thrombosis associated with transient free protein S deficiency after L-asparaginase treatment: case report and review of the literature.
Ketosis
Hyperglycemia, ketoacidosis and other complications of L-asparaginase in children with acute lymphoblastic leukemia.
Ketosis
[Transient diabetes mellitus with ketoacidosis in a child during the treatment of acute lymphoblastic leukemia with L-asparaginase]
Leishmaniasis
L-Asparaginase as a new molecular target against leishmaniasis: insights into the mechanism of action and structure-based inhibitor design.
Leukemia
A child with myeloid/natural killer cell precursor acute leukemia treated successfully with acute myeloid leukemia-oriented chemotherapy incorporating l-asparaginase.
Leukemia
A Novel l-Asparaginase with low l-Glutaminase Coactivity Is Highly Efficacious against Both T- and B-cell Acute Lymphoblastic Leukemias
Leukemia
Abnormal glucose tolerance in children with acute leukemia. Effect of induction chemotherapy including L-asparaginase.
Leukemia
Activity of vincristine, L-ASP, and dexamethasone against acute lymphoblastic leukemia is enhanced by the BH3-mimetic ABT-737 in vitro and in vivo.
Leukemia
Acute mixed lineage leukemia in children: The experience of St. Jude Children's Research Hospital.
Leukemia
Addition of rubidomycin to induction treatment with vincristine, prednisone, and L-asparaginase in standard-risk childhood acute lymphocytic leukemia (study ALL V): a report on behalf of the Dutch Childhood Leukemia Study Group.
Leukemia
Adipocytes cause leukemia cell resistance to L-asparaginase via release of glutamine.
Leukemia
Aggressive NK-cell leukemia: Therapeutic potentials of L-asparaginase and allogeneic hematopoietic stem cell transplantation.
Leukemia
Amino acid content of L5178Y and L5178Y/L-ASE cells after L-asparaginase treatment.
Leukemia
An experience with plasma exhcange treatment of acute lymphoblastic leukemia in a case with fulminant hepatitis related to l-asparaginase.
Leukemia
Antibody response to Escherichia coli L-asparaginase. Prognostic significance and clinical utility of antibody measurement.
Leukemia
Antitumor effect of L-alanosine (NSC 153553) on sensitive and resistant sublines of murine leukemias.
Leukemia
Arginine deiminase inhibits proliferation of human leukemia cells more potently than asparaginase by inducing cell cycle arrest and apoptosis.
Leukemia
Asparaginase immune complexes induce Fc-?RIII-dependent hypersensitivity in naive mice.
Leukemia
Asparagine plays a critical role in regulating cellular adaptation to glutamine depletion.
Leukemia
Asparagine synthetase is partially localized to the plasma membrane and upregulated by L-asparaginase in U937 cells.
Leukemia
Autophagy inhibition as a potential future targeted therapy for ETV6-RUNX1 driven B-cell precursor acute lymphoblastic leukemia.
Leukemia
Biochemical characterization of a novel L-Asparaginase with low glutaminase activity from Rhizomucor miehei and its application in food safety and leukemia treatment.
Leukemia
Cerebrovascular complications of L-asparaginase therapy in children with leukemia: aphasia and other neuropsychological deficits.
Leukemia
Characterization of inhibitors acting at the synthetase site of Escherichia coli asparagine synthetase B.
Leukemia
Characterization of polyethylene glycol-modified L-asparaginase from Escherichia coli and its application to therapy of leukemia.
Leukemia
Clinical relevance of in vitro chemoresistance in childhood acute myeloid leukemia.
Leukemia
Clinical results of treatment with E. coli L-asparaginase in adults with leukemia, lymphoma, and solid tumors.
Leukemia
Combination chemotherapy with cytosine arabinoside, L-asparaginase, and 6-azauridine for transplantable murine leukemias.
Leukemia
Comparison of daily and twice-weekly schedule of L-asparaginase in childhood leukemia.
Leukemia
Comparison of daily versus weekly L-asparaginase for the treatment of childhood acute leukemia.
Leukemia
Confinement of Therapeutic Enzymes in Selectively Permeable Polymer Vesicles by Polymerization-Induced Self-Assembly (PISA) Reduces Antibody Binding and Proteolytic Susceptibility.
Leukemia
Correlation between decreased apoptosis and multidrug resistance (MDR) in murine leukemic T cell lines.
Leukemia
Cytoenzymochemical effects of some antiblastic drugs and prediction of response to chemotherapy in acute leukemias.
Leukemia
De novo transcriptome of the cosmopolitan dinoflagellate Amphidinium carterae to identify enzymes with biotechnological potential.
Leukemia
Deamination of glutamine is a prerequisite for optimal asparagine deamination by asparaginases in vivo (CCG-1961).
Leukemia
Development of a double-drug-resistant human leukemia model to cytosine arabinoside and L-asparaginase: evaluation of cross-resistance to other treatment modalities.
Leukemia
Dietary thiamine influences l-asparaginase sensitivity in a subset of leukemia cells.
Leukemia
Dysmetabolic and neurological complications in leukemia patients treated with L-asparaginase.
Leukemia
E. coli L-asparaginase in the treatment of leukemia and solid tumors in 131 children.
Leukemia
Early detection of chemotherapy-related pancreatic enlargement in children using abdominal sonography: a preliminary report.
Leukemia
Effect of chemical modification with carboxymethyl dextran on kinetic and structural properties of L-asparaginase.
Leukemia
Effect of L-asparaginase administration on coagulation and platelet function in children with leukemia.
Leukemia
Effect of l-asparaginase and asparagine deprivation on RNA metabolism in mouse leukemia L 5178Y cells in suspension culture.
Leukemia
Effect of L-Asparaginase Combined with Vincristine and Prednisolone on Acute Myeloblastic Leukemia (M0) Associated with Non-Hodgkin Lymphoma.
Leukemia
Effect of L-asparaginase therapy upon serum pseudocholinesterase and ceruloplasmin levels in patients with acute leukemia.
Leukemia
Effect of the antileukemic agent L-asparaginase on thyroxine-binding globulin and albumin synthesis in cultured human hepatoma (HEP G2) cells.
Leukemia
Effective dose of L-asparaginase for induction of remission in previously treated children with acute lymphocytic leukemia: a report from Childrens Cancer Study Group.
Leukemia
Effectiveness of rubidomycin in induction therapy with vincristine, prednisone, and L-asparaginase for standard risk childhood acute lymphocytic leukemia: results of a Dutch phase III study (ALL V). A report on behalf of the Dutch Childhood Leukemia Study Group (DCLSG).
Leukemia
Effects of L-asparaginase on the two cases of acute leukemia with mediastinal tumors as initial signs.
Leukemia
Effects of polyethylene glycol attachment on physicochemical and biological stability of E. coli L-asparaginase.
Leukemia
Entrapment of L-asparaginase in red blood cells. A strategy to improve treatment of acute lymphoblastic leukemia.
Leukemia
Erwinia- and E. coli-derived L-asparaginase have similar effects on hemostasis. Pilot study in 10 patients with acute lymphoblastic leukemia.
Leukemia
Establishment of real-time polymerase chain reaction method for quantitative analysis of asparagine synthetase expression.
Leukemia
Evaluation of dose and schedule of L-asparaginase in multidrug therapy of childhood leukemia.
Leukemia
Evaluation of intensive postremission chemotherapy for adults with acute nonlymphocytic leukemia using high-dose cytosine arabinoside with L-asparaginase and amsacrine with etoposide.
Leukemia
Evaluation of intramuscular versus intravenous administration of L-asparaginase in childhood leukemia.
Leukemia
Evaluation of prednisolone and vincristine with and without L-asparaginase in acute lymphatic leukemia of childhood.
Leukemia
Extracellular expression and single step purification of recombinant Escherichia coli L-asparaginase II.
Leukemia
Genetic and metabolic engineering approaches for the production and delivery of L-asparaginases: An overview.
Leukemia
Genistein enhances the effects of L-asparaginase on inducing cell apoptosis in human leukemia cancer HL-60 cells.
Leukemia
Glutaminase Activity of L-Asparaginase Contributes to Durable Preclinical Activity against Acute Lymphoblastic Leukemia.
Leukemia
Glutamine-dependent asparagine synthetase from leukemia cells. Chloride dependence, mechanism of action, and inhibition.
Leukemia
Greater decrease of fibrinogen as compared to antithrombin III in L-asparaginase treated leukemia patients.
Leukemia
Growth inhibitory and proapoptotic effects of l-asparaginase from Fusarium culmorum ASP-87 on human leukemia cells (Jurkat).
Leukemia
Heterologous expression and purification of active L-asparaginase I of Saccharomyces cerevisiae in Escherichia coli host.
Leukemia
High-dose cytosine arabinoside and L-asparaginase therapy for poor-risk adult acute nonlymphocytic leukemia. A retrospective study.
Leukemia
Human monocytic leukemia expresses low levels of asparagine synthase and is potentially sensitive to L-asparaginase.
Leukemia
Hyperglycemia induced by chemotherapeutic agents used in acute lymphoblastic leukemia: report of three cases.
Leukemia
Hypersensitive reactions and antibody formation during L-asparaginase treatment of children and adults with acute leukemia.
Leukemia
Immunological and pharmacological characterization of poly-DL-alanyl-modified Erwinia carotovora L-asparaginase.
Leukemia
In vitro and in vivo killing of acute lymphoblastic leukemia cells by L-asparaginase.
Leukemia
In vivo pharmacokinetic features, toxicity profile, and chemosensitizing activity of alpha-cyano-beta-hydroxy-beta- methyl-N-(2,5-dibromophenyl)propenamide (LFM-A13), a novel antileukemic agent targeting Bruton's tyrosine kinase.
Leukemia
Induction and characteristics of resistance to L-asparaginase (NSC-109229) in mouse leukemia L5178Y.
Leukemia
Induction of remission with l-Asparaginase, cyclophosphamide, cytosine arabinoside, and prednisolone in adult patients with acute leukemia.
Leukemia
Influence of two different Escherichia coli asparaginase preparations on fibrinolytic proteins in childhood ALL.
Leukemia
Insights into the microbial L-asparaginases: from production to practical applications.
Leukemia
L-asparaginase effects on intact murine leukemia cells and on isolated cell plasma membranes.
Leukemia
l-Asparaginase from Aspergillus spp.: production based on kinetics, thermal stability and biochemical characterization.
Leukemia
L-asparaginase induced alteration of amethopterin (methotrexate) activity in mouse leukemia L5178Y.
Leukemia
L-asparaginase therapy for leukemia and other malignant neoplasms. Remission in human leukemia.
Leukemia
L-asparaginase therapy in children with advanced leukemia. The Southwest Cancer Chemotherapy Study Group.
Leukemia
L-asparaginase therapy with concomitant cranial venous thrombosis: can MRI help avoiding stroke.
Leukemia
L-Asparaginase, vincristine, and prednisone for induction of first remission in acute lymphocytic leukemia.
Leukemia
L-asparaginase-based treatment of 15 western patients with extranodal NK/T-cell lymphoma and leukemia and a review of the literature.
Leukemia
L-asparaginase-induced modulation of methotrexate polyglutamylation in murine leukemia L5178Y.
Leukemia
L-Asparaginase: human toxicology and single agent activity in nonleukemic neoplasms.
Leukemia
Metabolic profile of leukemia cells influences treatment efficacy of L-asparaginase.
Leukemia
Methotrexate plus L-asparaginase. An active combination for children with acute nonlymphocytic leukemia.
Leukemia
Methotrexate/L-asparaginase combination chemotherapy for patients with acute leukemia in relapse: a study of 36 children.
Leukemia
Partial purification and anti-leukemic activity of L-asparaginase enzyme of the actinomycete strain LA-29 isolated from the estuarine fish, Mugil cephalus (Linn.).
Leukemia
Patient stratification based on prednisolone-vincristine-asparaginase resistance profiles in children with acute lymphoblastic leukemia.
Leukemia
Pharmacological and clinical evaluation of L-asparaginase in the treatment of leukemia.
Leukemia
Phase I study of dexamethasone, methotrexate, ifosfamide, L-asparaginase, and etoposide (SMILE) chemotherapy for advanced-stage, relapsed or refractory extranodal natural killer (NK)/T-cell lymphoma and leukemia.
Leukemia
Plasma ammonia concentration after L-asparaginase therapy in 27 dogs with high-grade lymphoma or leukemia.
Leukemia
Preliminary in vivo evaluation of the protein transduction domain-modified ATTEMPTS approach in enhancing asparaginase therapy.
Leukemia
Preserving catalytic activity and enhancing biochemical stability of the therapeutic enzyme asparaginase by biocompatible multilayered polyelectrolyte microcapsules.
Leukemia
Production, purification, characterization, antioxidant and antiproliferative activities of extracellular L-asparaginase produced by Fusarium equiseti AHMF4.
Leukemia
Protracted Administration of L-Asparaginase in Maintenance Phase Is the Risk Factor for Hyperglycemia in Older Patients with Pediatric Acute Lymphoblastic Leukemia.
Leukemia
Purification and biotechnological applications of L-asparaginase from newly isolated Bacillus halotolerans OHEM18 as antitumor and antioxidant agent.
Leukemia
Purification and characterization of a novel and robust L-asparaginase having low-glutaminase activity from Bacillus licheniformis: in vitro evaluation of anti-cancerous properties.
Leukemia
Relationship between major vault protein/lung resistance protein, multidrug resistance-associated protein, P-glycoprotein expression, and drug resistance in childhood leukemia.
Leukemia
Remission induction with L-asparaginase, vincristine, and prednisone in children with acute nonlymphoblastic leukemia.
Leukemia
Result of a cooperative study with L-asparaginase in human leukemias. Report of the section "oncology" of the Paul-Ehrlich-Society for Chemotherapy.
Leukemia
Risk factors for hyperglycemia in children with leukemia receiving L-asparaginase and prednisone.
Leukemia
Sequential combination of methotrexate and L-asparaginase in the treatment of refractory acute leukemia.
Leukemia
Sequential high-dose ara-C and asparaginase versus high-dose ara-C alone in the treatment of patients with relapsed and refractory acute leukemias.
Leukemia
Sequential high-dose cytosine arabinoside and L-asparaginase in childhood leukemia in relapse.
Leukemia
Short courses of cytosine arabinoside and L-asparaginase in children with acute leukemia.
Leukemia
Some clinical observations on the treatment with L-asparaginase of the acute leukemias.
Leukemia
Spleen focus assays with a mouse leukemia virus in mice treated with actinomycin D, L-asparaginase or rifampicin.
Leukemia
Study of cytosine arabinoside (NSC-63878) synchronization plus vincristine (NSC-67574), prednisone (NSC-10023), and L-asparaginase (NSC-109229) for remission induction in advanced acute leukemia in children.
Leukemia
Successful disease control with l-asparaginase monotherapy for aggressive natural killer cell leukemia with severe hepatic failure.
Leukemia
Successful use of octreotide as a chemoprotectant for prevention of PEG-asparaginase-induced pancreatitis.
Leukemia
Suppression of murine leukemias by L-asparaginase. Incidence of sensitivity among leukemias of various types: comparative inhibitory activities of guinea pig serum L-asparaginase and Escherichia coli L-asparaginase.
Leukemia
Synthetic lethality of glutaminolysis inhibition, autophagy inactivation and asparagine depletion in colon cancer.
Leukemia
Taxotere and vincristine inhibit the secretion of the angiogenesis inducing vascular endothelial growth factor (VEGF) by wild-type and drug-resistant human leukemia T-cell lines.
Leukemia
The combination regimen of idarubicin and taxotere is effective against human drug-resistant leukemic cell lines.
Leukemia
The effect of L-asparaginase on the nucleic acid metabolism and cell cycle of human leukemia cells.
Leukemia
The risk of thrombosis in patients with acute leukemia: occurrence of thrombosis at diagnosis and during treatment.
Leukemia
Therapy of refractory adult acute lymphoblastic leukemia with vincristine and prednisone plus tandem methotrexate and L-asparaginase. Results of a Cancer and Leukemia Group B Study.
Leukemia
Therapy with Erwinia L-asparaginase in children with acute leukemia after anaphylaxis to E. coli L-asparaginase.
Leukemia
Thiol-maleimide poly(ethylene glycol) crosslinking of L-asparaginase subunits at recombinant cysteine residues introduced by mutagenesis.
Leukemia
Toxic and antineoplastic effects of L-asparaginase. Study of mice with lymphoma and normal monkeys and report on a child with leukemia.
Leukemia
Treatment of a child with myeloid/NK cell precursor acute leukemia with L-asparaginase and unrelated cord blood transplantation.
Leukemia
Treatment of human B-cell precursor leukemia in SCID mice by using a combination of the anti-CD19 immunotoxin B43-PAP with the standard chemotherapeutic drugs vincristine, methylprednisolone, and L-asparaginase.
Leukemia
Ultrastructural changes in murine leukemia cells exposed to l-asparaginase in vitro.
Leukemia
Use of L-asparaginase in acute lymphoblastic leukemia: recommendations of the Polish Adult Leukemia Group.
Leukemia
ZBTB1 Regulates Asparagine Synthesis and Leukemia Cell Response to L-Asparaginase.
Leukemia
[Allergic reactions and antibody formation in children and adults treated with L-asparaginase for leukemia]
Leukemia
[Bacterial recombinant L-asparaginases: properties, structure and anti-proliferative activity].
Leukemia
[Cellular test system for studying the biological properties of preparations with L-asparaginase activity]
Leukemia
[Clinical trial of protocol-AL851 for children with high-risk acute lymphoblastic leukemia. Kyushu Yamaguchi Children's Cancer Study Group (KYCCSG)]
Leukemia
[Complete remission achieved by L-asparaginase, vincristine and prednisolone (LVP) therapy in secondary leukemia (M5a type) with an MLL gene rearrangement]
Leukemia
[Complete remission obtained in refractory acute lymphocytic leukemia using high-dose cytosine arabinoside combined with low-dose L-asparaginase]
Leukemia
[Complete remission of lymphosarcoma cell leukemia with BACOP and L-asparaginase therapy--report of a case (author's transl)]
Leukemia
[Current national and international status of supportive therapy for the coagulopathy associated with L-asparaginase containing regimen for acute lymphoblastic leukemia].
Leukemia
[Effect of L-asparaginase in small dosage on advanced leukemia in children (author's transl)]
Leukemia
[Efficiency of treatment of adult patients with acute T-lymphoblastic leukemia according to the ALL-2009 protocol of the Russian Acute Leukemia Study Group].
Leukemia
[Electron microscopic observations on the effect of L-asparaginase at transplanted leukemias of the mouse]
Leukemia
[Evaluation of new antileukemic agents, with special reference to L-asparaginase, and cyclic maintenance therapy in acute leukemia]
Leukemia
[High-dose cytosine arabinoside and L-asparaginase in the treatment of refractory or recurrent acute non-lymphoblastic leukemia]
Leukemia
[Inhibition of synthesis of protein and nucleic acid in mouse and human leukemia cells by L-asparaginase in vitro]
Leukemia
[L-asparaginase in combined treatment of acute leukemia not affecting the bone marrow]
Leukemia
[L-asparaginase therapy in 14 cases of acute lymphatic leukemia observed at the Clinica Pediatrica di Modena]
Leukemia
[Metabolic complications of the treatment of acute leukemia with L-asparaginase (apropos of 147 cases)]
Leukemia
[Progress in researches on anti-tumor agent L-asparaginase for treatment of leukemia]
Leukemia
[Relationship between asparagine synthetase expression level and cell sensitivity to L-asparaginase in human leukemic cell lines]
Leukemia
[Results of treatment of children with acute lymphatic leukemia (ALL) according to the ALL V protocol of the Netherlands Working Group on Leukemia in Children]
Leukemia
[Reversible posterior leukoencephalopathy syndrome probably caused by L-asparaginase]
Leukemia
[Sequential combination of high-dose cytosine arabinoside and L-asparaginase in the treatment of refractory acute leukemia and malignant lymphoma]
Leukemia
[Significance of L-asparaginase activity and biochemical parameters evaluation in children with acute lymphoblastic leukemia]
Leukemia
[Study of tumor cells sensitivity in patients with acute leukemia to cytokines and their combined use with drugs in vitro by MTT analysis]
Leukemia
[Successful readministration of L-asparaginase after development of severe hypertriglyceridemia in a young adult with T-cell acute lymphoblastic leukemia].
Leukemia
[Superior sagittal sinus thrombosis after intrathecal chemotherapy and intravenous high-dose cytarabine in an acute myeloid leukemia case with t(8;21)(q22;q22)].
Leukemia
[Surgery for neutropenic enterocolitis, a complication in acute lymphoblastic leukemia]
Leukemia
[The hematopoietic regeneration in acute lymphatic leukemia in the child under L-asparaginase treatment]
Leukemia
[Therapeutic effects and side effects of L-asparaginase on acute leukemia and multiple myeloma]
Leukemia
[Therapeutic results and prognostic factors in acute lymphatic leukemia in the adult]
Leukemia
[Transient diabetes mellitus induced by L-asparaginase in a patient with acute myeloblastic leukemia (author's transl)]
Leukemia
[Treatment of acute leukemia with the L-asparaginase. Preliminary results based on 84 cases]
Leukemia
[Treatment of adult acute leukemia with a combination of cytosine arabinoside, vincristine, 6-mercaptopurine, prednisolone, and L-asparaginase (author's transl)]
Leukemia
[Use of L-asparaginase (Krasnitin) in children with acute leukemia during repeated exacerbations]
Leukemia
[Use of L-asparaginase in the treatment of leukemia. Experiences from 4 Dutch hospitals]
Leukemia
[Use of L-asparaginase in therapy with special reference to acute lymphatic leukemia]
Leukemia P388
Antitumor effect of L-alanosine (NSC 153553) on sensitive and resistant sublines of murine leukemias.
Leukemia, Biphenotypic, Acute
[Reversible posterior leukoencephalopathy syndrome probably caused by L-asparaginase]
Leukemia, Large Granular Lymphocytic
Successful disease control with l-asparaginase monotherapy for aggressive natural killer cell leukemia with severe hepatic failure.
Leukemia, Lymphoid
Acrylic microspheres in vivo VI: antitumor effect of microparticles with immobilized L-asparaginase against 6C3HED lymphoma.
Leukemia, Lymphoid
Glutaraldehyde-Mediated Synthesis of Asparaginase-Bound Maghemite Nanocomposites: Cytotoxicity against Human Colon Adenocarcinoma Cells.
Leukemia, Lymphoid
L-Asparaginase: effect on 7S gamma globulin extents and germinal centers in spleen and lymph-nodes.
Leukemia, Lymphoid
Metabolic profile of leukemia cells influences treatment efficacy of L-asparaginase.
Leukemia, Lymphoid
Methotrexate followed by L-asparaginase for the treatment of acute non lymphoid leukemia.
Leukemia, Lymphoid
[High molecular weight L-asparaginase derivatives based on a water-soluble carboxymethyl cellulose: biological properties]
Leukemia, Lymphoid
[L-Asparaginase therapy in chemotherapy-resistant acute lymphocytic leukemias (author's transl)]
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Idarubicin in the initial treatment of adults with acute lymphoblastic leukemia: the effect of drug schedule on outcome.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Intensive therapy for adult acute lymphoblastic leukemia: preliminary results of the idarubicin/vincristine/L-asparaginase/prednisolone regimen.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Treatment of L-asparaginase allergic reaction.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Treatment of the lymphoid blast crisis of chronic myeloid leukemia.
Leukemia, Myeloid
Characterization of childhood acute leukemia with multiple myeloid and lymphoid markers at diagnosis and at relapse.
Leukemia, Myeloid, Acute
Acute myeloid leukemia with mediastinal myeloid sarcoma refractory to acute myeloid leukemia therapy but responsive to L-asparaginase.
Leukemia, Myeloid, Acute
Antiproliferative effects of L-asparaginase in acute myeloid leukemia.
Leukemia, Myeloid, Acute
Effect of L-Asparaginase Combined with Vincristine and Prednisolone on Acute Myeloblastic Leukemia (M0) Associated with Non-Hodgkin Lymphoma.
Leukemia, Myeloid, Acute
Effects of harringtonine in combination with acivicin, adriamycin, L-asparaginase, cytosine arabinoside, dexamethasone, fluorouracil or methotrexate on human acute myelogenous leukemia cell line KG-1.
Leukemia, Myeloid, Acute
Evaluation of intensive postremission chemotherapy for adults with acute nonlymphocytic leukemia using high-dose cytosine arabinoside with L-asparaginase and amsacrine with etoposide.
Leukemia, Myeloid, Acute
High dose cytarabine, mitoxantrone and l-asparaginase (HAMA) salvage for relapsed or refractory acute myeloid leukemia (AML) in the elderly.
Leukemia, Myeloid, Acute
High-dose cytosine arabinoside and L-asparaginase therapy for poor-risk adult acute nonlymphocytic leukemia. A retrospective study.
Leukemia, Myeloid, Acute
Identification of a cytogenetic and molecular subgroup of acute myeloid leukemias showing sensitivity to L-Asparaginase.
Leukemia, Myeloid, Acute
Methotrexate plus L-asparaginase. An active combination for children with acute nonlymphocytic leukemia.
Leukemia, Myeloid, Acute
Red blood cell-encapsulated L-asparaginase: potential therapy of patients with asparagine synthetase deficient acute myeloid leukemia.
Leukemia, Myeloid, Acute
Remission induction with L-asparaginase, vincristine, and prednisone in children with acute nonlymphoblastic leukemia.
Leukemia, Myeloid, Acute
Synergy between high-dose cytarabine and asparaginase in the treatment of adults with refractory and relapsed acute myelogenous leukemia--a Cancer and Leukemia Group B Study.
Leukemia, Myeloid, Acute
Thiol-maleimide poly(ethylene glycol) crosslinking of L-asparaginase subunits at recombinant cysteine residues introduced by mutagenesis.
Leukemia, Myeloid, Acute
Treatment of poor risk acute leukemia with sequential high-dose ARA-C and asparaginase.
Leukemia, Myeloid, Acute
[The apoptosis-inducing potential of L-asparaginase in acute myeloid leukemia cells].
Leukemia, Myeloid, Acute
[Transient diabetes mellitus induced by L-asparaginase in a patient with acute myeloblastic leukemia (author's transl)]
Leukemia, T-Cell
Asparaginase treatment side-effects may be due to genes with homopolymeric Asn codons (Review-Hypothesis).
Leukemia, T-Cell
Growth inhibitory and proapoptotic effects of l-asparaginase from Fusarium culmorum ASP-87 on human leukemia cells (Jurkat).
Leukemia, T-Cell
Use of L-asparaginase and cytosine arabinoside for refractory acute lymphocytic leukemia with particular reference to T-cell leukemia.
Leukoencephalopathies
[Posterior reversible leukoencephalopathy syndrome induced by L-asparaginase in a teenage female diagnosed with acute lymphoblastic leukemia].
Leukoencephalopathies
[Reversible posterior leukoencephalopathy syndrome probably caused by L-asparaginase]
Liver Cirrhosis
Quantitation of plasma levels of tetranectin--effects of oral contraceptives, pregnancy, treatment with L-asparaginase and liver cirrhosis.
Liver Diseases
L-Asparaginase in the treatment of refractory and relapsed extranodal NK/T-cell lymphoma, nasal type.
Liver Failure
Fatal Liver Failure in an Adult Patient with Acute Lymphoblastic Leukemia following Treatment with L-Asparaginase.
Liver Failure
Risk factors for the development of hospital-acquired pediatric venous thromboembolism-Dealing with potentially causal and confounding risk factors using a directed acyclic graph (DAG) analysis.
Liver Failure
Successful disease control with l-asparaginase monotherapy for aggressive natural killer cell leukemia with severe hepatic failure.
Liver Neoplasms, Experimental
Potential inhibitors of L-asparagine biosynthesis. 5. Electrophilic amide analogues of (S)-2,3-diaminopropionic acid.
Lung Neoplasms
Randomized phase II comparison of methotrexate with or without L-asparaginase in non-small cell cancer of the lung.
Lung Neoplasms
Synthesis, characterization and synergistic activity of cerium-selenium nanobiocomposite of fungal l-asparaginase against lung cancer.
Lung Neoplasms
Yarrowia lipolytica L-asparaginase inhibits the growth and migration of lung (A549) and breast (MCF7) cancer cells.
Lupus Erythematosus, Systemic
[Treatment of systemic lupus erythematosus with L-asparaginase: considerations on a case]
Lymphohistiocytosis, Hemophagocytic
Successful treatment of extranodal natural killer/T-cell lymphoma, nasal type, complicated by severe hemophagocytic syndrome, with dexamethasone, methotrexate, ifosfamide, L-asparaginase, and etoposide chemotherapy followed by autologous stem cell transplant.
Lymphoma
A clinically attainable dose of L-asparaginase targets glutamine addiction in lymphoid cell lines.
Lymphoma
A phase II prospective study of the "Sandwich" protocol, L-asparaginase, cisplatin, dexamethasone and etoposide chemotherapy combined with concurrent radiation and cisplatin, in newly diagnosed, I/II stage, nasal type, extranodal natural killer/T-cell lymphoma.
Lymphoma
A pilot study evaluating changes in pancreatic lipase immunoreactivity concentrations in canines treated with L-asparaginase (ASNase), vincristine, or both for lymphoma.
Lymphoma
A prospective phase II study of L-asparaginase- CHOP plus radiation in newly diagnosed extranodal NK/T-cell lymphoma, nasal type.
Lymphoma
Acrylic microspheres in vivo VI: antitumor effect of microparticles with immobilized L-asparaginase against 6C3HED lymphoma.
Lymphoma
Allogeneic hematopoietic stem cell transplant following chemotherapy containing l-asparaginase as a promising treatment for patients with relapsed or refractory extranodal natural killer/T cell lymphoma, nasal type.
Lymphoma
Antibody response to Escherichia coli L-asparaginase. Prognostic significance and clinical utility of antibody measurement.
Lymphoma
Antitumor activity of L-asparaginase from Cylindrocarpon obtusisporum MB-10 and its effect on the immune system.
Lymphoma
Antitumor effect of hippurate. An experimental study using various mouse tumor strains.
Lymphoma
Autologous marrow transplantation as consolidation therapy for canine lymphoma: efficacy and toxicity of various regimens of total body irradiation.
Lymphoma
Changes in hemostatic and fibrinolytic proteins in patients receiving L-asparaginase therapy.
Lymphoma
Characterization of hypertriglyceridemia induced by L-asparaginase therapy for acute lymphoblastic leukemia and malignant lymphoma.
Lymphoma
Chemotherapy versus chemotherapy with intralymphatic tumor cell vaccine in canine lymphoma.
Lymphoma
Clinical results of treatment with E. coli L-asparaginase in adults with leukemia, lymphoma, and solid tumors.
Lymphoma
Clinical study of l-asparaginase in the treatment of extranodal NK/T-cell lymphoma, nasal type.
Lymphoma
Combination chemotherapy with continuous L-asparaginase, lomustine, and prednisone for relapsed canine lymphoma.
Lymphoma
Combination chemotherapy with L-asparaginase, lomustine, and prednisone for relapsed or refractory canine lymphoma.
Lymphoma
Combination of CCNU and DTIC chemotherapy for treatment of resistant lymphoma in dogs.
Lymphoma
Combination of gemcitabine, L-asparaginase, and oxaliplatin (GELOX) is superior to EPOCH or CHOP in the treatment of patients with stage IE/IIE extranodal natural killer/T cell lymphoma: a retrospective study in a cohort of 227 patients with long-term follow-up.
Lymphoma
Combined immune checkpoint blockade and radiotherapy induces durable remission in relapsed natural killer/T-cell lymphoma: a case report and review of the literature.
Lymphoma
Comparison of combination l-asparaginase plus CHOP or modified MOPP treatment protocols in dogs with multi-centric T-cell or hypercalcaemic lymphoma.
Lymphoma
Comparison of gemcitabine, oxaliplatin and L-asparaginase and etoposide, vincristine, doxorubicin, cyclophosphamide and prednisone as first-line chemotherapy in patients with stage IE to IIE extranodal natural killer/T-cell lymphoma: a multicenter retrospective study.
Lymphoma
Comparison of glycine metabolism in mouse lymphoma cells either sensitive or resistant to L-asparaginase.
Lymphoma
Comparison of Native Escherichia Coli L-Asparaginase Versus Pegylated Asparaginase, in Combination with Ifosfamide, Methotrexate, Etoposide, and Prednisolone (IMEP), in Extranodal NK/T Cell Lymphoma, Nasal Type (NTCL).
Lymphoma
Concurrent Epstein-Barr virus associated NK/T cell lymphoma after immunosuppressive therapy for aplastic anemia: report of a case and review of literature.
Lymphoma
Concurrent use of rabacfosadine and L-asparaginase for relapsed or refractory multicentric lymphoma in dogs.
Lymphoma
Development of an ELISA to detect circulating anti-asparaginase antibodies in dogs with lymphoid neoplasia treated with Escherichia coli l-asparaginase(*).
Lymphoma
Differential mechanisms of asparaginase resistance in B-type acute lymphoblastic leukemia and malignant natural killer cell lines.
Lymphoma
Does L-asparaginase influence efficacy or toxicity when added to a standard CHOP protocol for dogs with lymphoma?
Lymphoma
E. coli-Derived L-Asparaginase Retains Enzymatic and Cytotoxic Activity In Vitro for Canine and Feline Lymphoma after Cold Storage.
Lymphoma
Effects of L-asparaginase on plasma amino acid profiles and tumor burden in cats with lymphoma.
Lymphoma
Effects of single-dose L-asparaginase on coagulation values in healthy dogs and dogs with lymphoma.
Lymphoma
Efficacy and adverse events of continuous l-asparaginase administration for canine large cell lymphoma of presumed gastrointestinal origin.
Lymphoma
Efficacy of gemcitabine combined with oxaliplatin, L-asparaginase and dexamethasone in patients with newly-diagnosed extranodal NK/T-cell lymphoma.
Lymphoma
Efficacy of L-asparaginase with methotrexate and dexamethasone (AspaMetDex regimen) in patients with refractory or relapsing extranodal NK/T-cell lymphoma, a phase 2 study.
Lymphoma
Efficacy of pegaspargase in extra nodal natural killer/T-cell lymphoma nasal type: A case report from China.
Lymphoma
Endovascular mechanical thrombectomy for superior sagittal sinus thrombosis in a patient with T-lymphoblastic lymphoma treated with L-asparaginase.
Lymphoma
Enhancement in biological activity of L-asparginase by its conjugation on silica nanoparticles.
Lymphoma
Epigenetic Silencing Affects l-Asparaginase Sensitivity and Predicts Outcome in T-ALL.
Lymphoma
Erratum for Concurrent use of rabacfosadine and L-asparaginase for relapsed or refractory multicentric lymphoma in dogs.
Lymphoma
Evaluation of an actinomycin-D-containing combination chemotherapy protocol with extended maintenance therapy for canine lymphoma.
Lymphoma
Evaluation of L-asparaginase: polyethylene glycol conjugate versus native L-asparaginase combined with chemotherapy. A randomized double-blind study in canine lymphoma.
Lymphoma
Evaluation of Pgp (MDR1) immunohistochemistry in canine lymphoma - prognostic and clinical aspects.
Lymphoma
Evidence that the L-asparaginase of guinea pig serum is responsible for its antilymphoma effects. II. Lymphoma 6C3HED cells cultured in a medium devoid of L-asparagine lose their susceptibility to the effects of guinea pig serum in vivo.
Lymphoma
Failure of combination therapy with S-carbamyl-L-cysteine (SCC; NSC-102498) and L-asparaginase (NSC-109229) for L-asparaginase-resistant mouse lymphoma.
Lymphoma
First-line combination of gemcitabine, oxaliplatin, and L-asparaginase (GELOX) followed by involved-field radiation therapy for patients with stage IE/IIE extranodal natural killer/T-cell lymphoma.
Lymphoma
Five-year analysis from phase 2 trial of "sandwich" chemoradiotherapy in newly diagnosed, stage IE to IIE, nasal type, extranodal natural killer/T-cell lymphoma.
Lymphoma
Genetic and metabolic engineering approaches for the production and delivery of L-asparaginases: An overview.
Lymphoma
Glutamate oxidation of 6C3HED lymphoma: effects of L-asparaginase on sensitive and resistant lines.
Lymphoma
High efficacy of monomethoxypolyethylene glycol-conjugated L-asparaginase (PEG2-ASP) in two patients with hematological malignancies.
Lymphoma
Immunological studies on modified enzymes. I. soluble L-asparaginase/mouse albumin copolymer with enzyme activity and substantial loss of immunogenicity.
Lymphoma
In vitro immune monitoring of antibody response in dogs given chemoimmunotherapy for lymphoma.
Lymphoma
Increased antitumor activity of Escherichia coli. L-asparaginase by modification with monomethoxypolyethylene glycol.
Lymphoma
Increased toxicity of P-glycoprotein-substrate chemotherapeutic agents in a dog with the MDR1 deletion mutation associated with ivermectin sensitivity.
Lymphoma
Induction treatment with SMILE and consolidation with autologous stem cell transplantation for newly diagnosed stage IV extranodal natural killer/T-cell lymphoma patients.
Lymphoma
Insights into the microbial L-asparaginases: from production to practical applications.
Lymphoma
Ki-67 Can Predict the Response to the Gemcitabine, Oxaliplatin And L-asparaginase Regimen (GELOX) and Prognosis in Patients with Nasal Natural Killer/T-cell Lymphoma.
Lymphoma
L-Asparaginase for newly diagnosed extra-nodal NK/T-cell lymphoma: systematic review and meta-analysis.
Lymphoma
L-Asparaginase in the treatment of refractory and relapsed extranodal NK/T-cell lymphoma, nasal type.
Lymphoma
L-asparaginase induced durable remission of relapsed nasal NK/T-cell lymphoma after autologous peripheral blood stem cell transplantation.
Lymphoma
L-Asparaginase, Doxorubicin, Vincristine, and Prednisolone (LHOP) Chemotherapy as a First-Line Treatment for Dogs with Multicentric Lymphoma.
Lymphoma
L-asparaginase-based treatment of 15 western patients with extranodal NK/T-cell lymphoma and leukemia and a review of the literature.
Lymphoma
L-asparaginase: early findings and current studies on the metabolism of L-asparagine in lymphoma cells.
Lymphoma
L-Asparaginase: effect on 7S gamma globulin extents and germinal centers in spleen and lymph-nodes.
Lymphoma
L-asparaginyl-tRNA synthetase and L-asparagine synthetase activities of L-asparaginase-sensitive and -resistant forms of the mouse Gardner lymphoma 6C3HED.
Lymphoma
Marked cytoreduction of a lymphocyte-rich mediastinal thymoma with neoadjuvant chemotherapy in a cat.
Lymphoma
Massive uric acid crystalluria and cylinduria in a dog after l-asparaginase treatment for lymphoma.
Lymphoma
Midline NK/T-cell lymphoma nasal-type: treatment outcome, the effect of L-asparaginase based regimen, and prognostic factors.
Lymphoma
Modified SMILE (mSMILE) and intensity-modulated radiotherapy (IMRT) for extranodal NK-T lymphoma nasal type in a single-center population.
Lymphoma
Nasal extranodal peripheral NK/T-cell lymphoma treated by the protocol NK/T-cell high-dose-methotrexate L-asparaginase dexamethasone.
Lymphoma
Neutropenia associated with vincristine and L-asparaginase induction chemotherapy for canine lymphoma.
Lymphoma
PD1 blockade with low-dose nivolumab in NK/T cell lymphoma failing L-asparaginase: efficacy and safety.
Lymphoma
PD1 blockade with pembrolizumab is highly effective in relapsed or refractory NK/T-cell lymphoma failing l-asparaginase.
Lymphoma
PEG-L-CHOP treatment is safe and effective in adult extranodal NK/T-cell lymphoma with a low rate of clinical hypersensitivity.
Lymphoma
Pegaspargase, gemcitabine, dexamethasone, and cisplatin (P-GDP) combined chemotherapy is effective for newly diagnosed extranodal NK/T-cell lymphoma: a retrospective study.
Lymphoma
Pembrolizumab in newly diagnosed EBV-negative extranodal natural killer/T-cell lymphoma: A case report.
Lymphoma
Pharmacology, immunogenicity, and efficacy of a novel pegylated recombinant Erwinia chrysanthemi-derived L-asparaginase.
Lymphoma
Phase 2 trial of "Sandwich" L-asparaginase, vincristine, and prednisone chemotherapy with radiotherapy in newly diagnosed, stage IE to IIE, nasal type, extranodal natural killer/T-cell lymphoma.
Lymphoma
Phase I study of dexamethasone, methotrexate, ifosfamide, L-asparaginase, and etoposide (SMILE) chemotherapy for advanced-stage, relapsed or refractory extranodal natural killer (NK)/T-cell lymphoma and leukemia.
Lymphoma
Phase II study of sequential chemoradiotherapy with L-asparaginase, dexamethasone, ifosfamide, cisplatin, and etoposide (DICE-L) in the early stage of extranodal natural killer (NK)/T-cell lymphoma.
Lymphoma
Phase II study of SMILE chemotherapy for newly diagnosed stage IV, relapsed, or refractory extranodal natural killer (NK)/T-cell lymphoma, nasal type: the NK-Cell Tumor Study Group study.
Lymphoma
Phase II trial of concurrent chemoradiotherapy with L-asparaginase and MIDLE chemotherapy for newly diagnosed stage I/II extranodal NK/T-cell lymphoma, nasal type (CISL-1008).
Lymphoma
Pralatrexate as a bridge to allogeneic hematopoietic stem cell transplantation in a patient with advanced-stage extranodal nasal-type natural killer/T cell lymphoma refractory to first-line chemotherapy: a case report.
Lymphoma
Prediction and prevention of central nervous system relapse in patients with extranodal natural killer/T-cell lymphoma.
Lymphoma
Preliminary in vivo evaluation of the protein transduction domain-modified ATTEMPTS approach in enhancing asparaginase therapy.
Lymphoma
Pretreatment EBV-DNA Copy Number Is Predictive of Response and Toxicities to SMILE Chemotherapy for Extranodal NK/T-cell Lymphoma, Nasal Type.
Lymphoma
Prompt detection of L-asparaginase inactivation is crucial to optimize treatment efficacy also in aggressive lymphomas.
Lymphoma
Proof-of-concept study: Evaluation of plasma and urinary electrolytes as markers of response to L-asparaginase therapy in dogs with high-grade lymphoma.
Lymphoma
Prospective evaluation of the safety of compounded bulk material L-asparaginase in dogs with lymphoma.
Lymphoma
Response of intracerebral Gardner lymphoma to guinea pig L-asparaginase and Escherichia coli L-asparaginase.
Lymphoma
Results of chemotherapy for cats with alimentary malignant lymphoma: 21 cases (1993-1997)
Lymphoma
Safety and effective salvage regimen comprising a novel combination of brentuximab vedotin, L-asparaginase, and dexamethasone for refractory anaplastic large cell lymphoma, anaplastic lymphoma kinase negative.
Lymphoma
Sequential DICE combined with l-asparaginase chemotherapy followed by involved field radiation in newly diagnosed, stage IE to IIE, nasal and extranodal NK/T-cell lymphoma.
Lymphoma
Serum C-reactive protein concentrations in dogs with multicentric lymphoma undergoing chemotherapy.
Lymphoma
Studies on the mechanism of tumor inhibition by L-asparaginase. Effects of the enzyme on asparagine levels in the blood, normal tissues, and 6C3HED lymphomas of mice: differences in asparagine formation and utilization in asparaginase-sensitive and -resistant lymphoma cells.
Lymphoma
Studies on the recombinant production and anticancer activity of thermostable L- asparaginase I from Pyrococcus abyssi.
Lymphoma
Study of L-Asparaginase, Vincristine, and Dexamethasone Combined With Intensity-modulated Radiation Therapy in Early-Stage Nasal NK/T-Cell Lymphoma.
Lymphoma
Successful full-dose DeVIC therapy in a patient with advanced-stage extranodal natural killer/T-cell lymphoma refractory to L-asparaginase.
Lymphoma
Successful treatment of extranodal natural killer/T-cell lymphoma, nasal type, complicated by severe hemophagocytic syndrome, with dexamethasone, methotrexate, ifosfamide, L-asparaginase, and etoposide chemotherapy followed by autologous stem cell transplant.
Lymphoma
Successful treatment with Erwinia L-asparaginase for recurrent natural killer/T cell lymphoma.
Lymphoma
Successful treatment with L-asparaginase based regimen for primary pulmonary NK/T cell lymphoma: a case report and review of the literature.
Lymphoma
The inhibition of lymphocyte blastogenesis by asparaginase: critical role of glutamine in both T and B lymphocyte transformation.
Lymphoma
Therapy of a murine lymphoma with tumor-specific antiserum in combination with adriamycin, cyclophosphamide, or L-asparaginase.
Lymphoma
Toxic and antineoplastic effects of L-asparaginase. Study of mice with lymphoma and normal monkeys and report on a child with leukemia.
Lymphoma
Treatment of a mouse lymphoma by L-asparaginase: success depends on the host's immune response.
Lymphoma
Treatment of feline lymphoma using a 12-week, maintenance-free combination chemotherapy protocol in 26 cats.
Lymphoma
Venous thromboembolism following L-asparaginase treatment for lymphoid malignancies in Korea.
Lymphoma
Ventricular fractional shortening in 108 dogs with malignant lymphoma undergoing chemotherapy with a cyclic combination protocol including doxorubicin.
Lymphoma
[A multi-center retrospective study of L-asparaginase-based regimens as first-line treatment in newly diagnosed extranodal NK/T-cell lymphoma].
Lymphoma
[Cellular test system for studying the biological properties of preparations with L-asparaginase activity]
Lymphoma
[Clinical analysis of autologous hematopoietic stem cell transplantation in the treatment of advanced/recurrent nasal type extranodal NK/T-cell lymphoma].
Lymphoma
[Complete remission obtained by sequential chemotherapy of L-asparaginase and continuous infusion of bleomycin (ABLE protocol) in a case of refractory diffuse large cell lymphoma of a paranasal origin]
Lymphoma
[Safety and adverse event profiling of pegylated L-asparaginase combined chemotherapy in the treatment of lymphoma].
Lymphoma
[Sequential combination of high-dose cytosine arabinoside and L-asparaginase in the treatment of refractory acute leukemia and malignant lymphoma]
Lymphoma
[Temporary effective treatment with L-asparaginase for a patient with refractory nasal NK/T-cell lymphoma]
Lymphoma, B-Cell
Retrospective analysis of doxorubicin and prednisone as first-line therapy for canine B-cell lymphoma.
Lymphoma, Large B-Cell, Diffuse
Biochemical characterization of U937 cells resistant to L-asparaginase: the role of asparagine synthetase.
Lymphoma, Large B-Cell, Diffuse
[Complete remission obtained by sequential chemotherapy of L-asparaginase and continuous infusion of bleomycin (ABLE protocol) in a case of refractory diffuse large cell lymphoma of a paranasal origin]
Lymphoma, Large-Cell, Anaplastic
Safety and effective salvage regimen comprising a novel combination of brentuximab vedotin, L-asparaginase, and dexamethasone for refractory anaplastic large cell lymphoma, anaplastic lymphoma kinase negative.
Lymphoma, Non-Hodgkin
A clinically attainable dose of L-asparaginase targets glutamine addiction in lymphoid cell lines.
Lymphoma, Non-Hodgkin
A critical analysis of L-asparaginase activity quantification methods-colorimetric methods versus high-performance liquid chromatography.
Lymphoma, Non-Hodgkin
A phase II trial of PEG-L-asparaginase in the treatment of non-Hodgkins lymphoma.
Lymphoma, Non-Hodgkin
Advantages in the use of L-asparaginase-albumin polymer as an antitumor agent.
Lymphoma, Non-Hodgkin
Changes in hemopoiesis of mice of the C3H strain following transplantation of Gardner lymphosarcoma and infection with LDH-virus. II. Spleen and bone marrow.
Lymphoma, Non-Hodgkin
Characterization of polyethylene glycol-modified L-asparaginase from Escherichia coli and its application to therapy of leukemia.
Lymphoma, Non-Hodgkin
Combination chemotherapy for advanced non-Hodgkin's lymphoma of unfavourable histology.
Lymphoma, Non-Hodgkin
Combination chemotherapy with L-asparaginase (EC-2) using P1798 lymphosarcoma.
Lymphoma, Non-Hodgkin
Combined immune checkpoint blockade and radiotherapy induces durable remission in relapsed natural killer/T-cell lymphoma: a case report and review of the literature.
Lymphoma, Non-Hodgkin
Early detection of chemotherapy-related pancreatic enlargement in children using abdominal sonography: a preliminary report.
Lymphoma, Non-Hodgkin
Effect of 9 alpha-fluoroprednisolone and L-asparaginase on uridine incorporation into ribosomal RNA of P1798 lymphosarcoma.
Lymphoma, Non-Hodgkin
Effect of L-Asparaginase Combined with Vincristine and Prednisolone on Acute Myeloblastic Leukemia (M0) Associated with Non-Hodgkin Lymphoma.
Lymphoma, Non-Hodgkin
Hyperglycemia associated with the therapeutic use of L-asparaginase: possible role of insulin receptors.
Lymphoma, Non-Hodgkin
Immunological aspects of L-asparaginase treatment in children with lymphoproliferative disease.
Lymphoma, Non-Hodgkin
In vivo and in vitro effects of the L-asparaginase fraction of guinea pig serum on the 6C3HED ascites lymphosarcoma.
Lymphoma, Non-Hodgkin
Increased serum trypsin and elastase-1 levels in patients undergoing L-asparaginase therapy.
Lymphoma, Non-Hodgkin
Inhibition of thymidine and basic amino acid metabolism in P1798 lymphosarcoma by L-asparaginase.
Lymphoma, Non-Hodgkin
L-asparaginase therapy and its complications in acute lymphoid leukaemia and generalized lymphosarcoma.
Lymphoma, Non-Hodgkin
Outcomes of treatment of children and adolescents with recurrent non-Hodgkin's lymphoma and Hodgkin's disease with dexamethasone, etoposide, cisplatin, cytarabine, and l-asparaginase, maintenance chemotherapy, and transplantation: Children's Cancer Group Study CCG-5912.
Lymphoma, Non-Hodgkin
Penicillium genus as a source for anti-leukemia compounds: an overview from 1984 to 2020.
Lymphoma, Non-Hodgkin
Plasma ammonia concentration after L-asparaginase therapy in 27 dogs with high-grade lymphoma or leukemia.
Lymphoma, Non-Hodgkin
Polyethylene glycol-L-asparaginase versus native L-asparaginase in canine non-Hodgkin's lymphoma.
Lymphoma, Non-Hodgkin
Proof-of-concept study: Evaluation of plasma and urinary electrolytes as markers of response to L-asparaginase therapy in dogs with high-grade lymphoma.
Lymphoma, Non-Hodgkin
Reversible MRI lesions due to pegaspargase treatment of non-Hodgkin's lymphoma.
Lymphoma, Non-Hodgkin
The effect of Yarrowia lipolytical-asparaginase on apoptosis induction and inhibition of growth in Burkitt's lymphoma Raji and acute lymphoblastic leukemia MOLT-4 cells.
Lymphoma, Non-Hodgkin
The in vivo effects of semipermeable microcapsules containing L-asparaginase on 6C3HED lymphosarcoma.
Lymphoma, Non-Hodgkin
Thiol-maleimide poly(ethylene glycol) crosslinking of L-asparaginase subunits at recombinant cysteine residues introduced by mutagenesis.
Lymphoma, Non-Hodgkin
[Adverse reactions associated with the use of L-asparaginase during therapy of patients with nB non-Hodgkin's lymphoma. Report of the Polish Paediatric LeuKaemia/Lymphoma Study Group]
Lymphoma, Non-Hodgkin
[Case of reticulum cell sarcoma treated with L-asparaginase and antibody to L-asparaginase]
Lymphoma, Non-Hodgkin
[Cellular test system for studying the biological properties of preparations with L-asparaginase activity]
Lymphoma, Non-Hodgkin
[Comparative evaluation of the clinical effectiveness of 3 preparations of E. coli L-asparaginase]
Lymphoma, Non-Hodgkin
[Complete remission of lymphosarcoma cell leukemia with BACOP and L-asparaginase therapy--report of a case (author's transl)]
Lymphoma, Non-Hodgkin
[Non-Hodgkin's lymphoma with transient abnormal glucose tolerance by the administration of L-asparaginase and prednisolone]
Lymphoma, Non-Hodgkin
[Repeated, 2-10 fold asparaginase treatments in children with lymphoproliferative diseases]
Lymphoma, Non-Hodgkin
[Results of repeated L-asparaginase treatment in acute lymphoblastic leukemia and lymphosarcoma in children]
Lymphoma, Non-Hodgkin
[Safety of polyethylene glycol conjugated L-asparaginase in patients with acute lymphoblastic leukemia and T cell non-Hodgkin lymphoma].
Lymphoma, Non-Hodgkin
[Sequential combination of high-dose cytosine arabinoside and L-asparaginase in the treatment of refractory acute leukemia and malignant lymphoma]
Lymphoma, Non-Hodgkin
[VAMA salvage regimen (VP-16, ARA-C, MTX and L-asparaginase) in relapsed or resistant non-Hodgkin's lymphoma]
Lymphoma, T-Cell
T-cell lymphoma with abundant CD20 expression showing a good response to rituximab with gemcitabine, oxiplatin, and L-asparaginase (R-pGEMOX): A case report.
Lymphoma, T-Cell
Topotecan combined with Ifosfamide, Etoposide, and L-asparaginase (TIEL) regimen improves outcomes in aggressive T-cell lymphoma.
Lymphoma, T-Cell, Cutaneous
L-asparaginase induced complete remission in Epstein-Barr virus positive, multidrug resistant, cutaneous T-cell lymphoma.
Lymphoma, T-Cell, Peripheral
Clinical analysis and prognostic significance of L-asparaginase containing multidrug chemotherapy regimen in incipient peripheral T-cell lymphoma.
Lymphoma, T-Cell, Peripheral
L-asparaginase-induced complete response in a relapsed patient with Epstein-Barr virus and cytotoxic peripheral T-cell lymphoma not otherwise specified.
Lymphoma, T-Cell, Peripheral
[A clinical observation of treatment of peripheral T-cell lymphoma with L-asparaginase-containing combination chemotherapy].
Lymphoma, T-Cell, Peripheral
[The efficacy of L-asparaginase in the treatment of refractory midline peripheral T-cell lymphoma]
Lymphoproliferative Disorders
Microbial L-asparaginase: purification, characterization and applications.
Malaria
Synthetic lethality of glutaminolysis inhibition, autophagy inactivation and asparagine depletion in colon cancer.
Massive Hepatic Necrosis
An experience with plasma exhcange treatment of acute lymphoblastic leukemia in a case with fulminant hepatitis related to l-asparaginase.
Medulloblastoma
Asparagine Depletion Potentiates the Cytotoxic Effect of Chemotherapy Against Brain Tumors.
Melanoma
Inhibitation by L-asparaginase from E. coli of human malignant melanoma cells growing in vitro.
Mesenteric Ischemia
Cryoprecipitate-induced mesenteric venous thrombosis during L-asparaginase therapy for acute lymphoblastic leukaemia.
Microcephaly
Asparagine synthetase deficiency detected by whole exome sequencing causes congenital microcephaly, epileptic encephalopathy and psychomotor delay.
Mucositis
Childhood non-Hodgkin's lymphoma--results of treatment with ALL high-risk protocol.
Mucositis
Toxicity of sequential high-dose ARA-C asparaginase treatment in childhood poor risk leukemia.
Multiple Myeloma
A Phase I-II trial of polyethylene glycol-conjugated L-asparaginase in patients with multiple myeloma.
Multiple Myeloma
Amino acid depletion triggered by ?-asparaginase sensitizes MM cells to carfilzomib by inducing mitochondria ROS-mediated cell death.
Multiple Myeloma
[Therapeutic effects and side effects of L-asparaginase on acute leukemia and multiple myeloma]
Myocardial Infarction
Myocardial infarction in a patient with acute lymphoblastic leukemia during L-asparaginase therapy.
Myocardial Infarction
Myocardial ischemia in a patient with acute lymphoblastic leukemia during L-asparaginase therapy.
Myocardial Infarction
The mutual relationship between the two molecular forms of the major fibrinolysis inhibitor alpha-2-antiplasmin in blood.
Myocardial Ischemia
Myocardial ischemia in a patient with acute lymphoblastic leukemia during L-asparaginase therapy.
Neoplasm Metastasis
Asparagine bioavailability governs metastasis in a model of breast cancer.
Neoplasm Metastasis
Development of L-Asparaginase Biobetters: Current Research Status and Review of the Desirable Quality Profiles.
Neoplasm Metastasis
Duration of in vivo effects of L-asparaginase on experimental metastasis.
Neoplasm Metastasis
Enhancement of metastases by L-asparaginase in allogeneic and isogeneic mouse tumor systems.
Neoplasm Metastasis
Prolonged control of hypoglycaemia by L-asparaginase in islet cell carcinoma producing insulin and gastrin.
Neoplasm Metastasis
SOX12 promotes colorectal cancer cell proliferation and metastasis by regulating asparagine synthesis.
Neoplasm Metastasis
Yarrowia lipolytica L-asparaginase inhibits the growth and migration of lung (A549) and breast (MCF7) cancer cells.
Neoplasm, Residual
Early T-cell precursor acute lymphoblastic leukaemia in children treated in AIEOP centres with AIEOP-BFM protocols: a retrospective analysis.
Neoplasm, Residual
Five-year single-center study of asparaginase therapy within the ALL-BFM 2000 trial.
Neoplasm, Residual
[Results of the treatment of adult acute lymphoblastic leukemia according to ALL-2005 protocol as a basis for new trials]
Neoplasms
51 Cr-L-asparagine accumulation by tumors: the influence of L-asparaginase treatment.
Neoplasms
A comprehensive review on microbial l-asparaginase: Bioprocessing, characterization, and industrial applications.
Neoplasms
A new pH indicator dye-based method for rapid and efficient screening of l-asparaginase producing microorganisms.
Neoplasms
A Patent Review on the Use of L-asparaginase in the Treatment of Acute Lymphocytic Leukemia.
Neoplasms
A pharmacoeconomic analysis of pegaspargase versus native Escherichia coli L-asparaginase for the treatment of children with standard-risk, acute lymphoblastic leukemia: the Children's Cancer Group study (CCG-1962).
Neoplasms
A phase I and pharmacodynamic evaluation of polyethylene glycol-conjugated L-asparaginase in patients with advanced solid tumors.
Neoplasms
A Phase I-II trial of polyethylene glycol-conjugated L-asparaginase in patients with multiple myeloma.
Neoplasms
A pilot study evaluating changes in pancreatic lipase immunoreactivity concentrations in canines treated with L-asparaginase (ASNase), vincristine, or both for lymphoma.
Neoplasms
Acrylic microspheres in vivo VI: antitumor effect of microparticles with immobilized L-asparaginase against 6C3HED lymphoma.
Neoplasms
Activity and safety of combination chemotherapy with methotrexate, ifosfamide, l-asparaginase and dexamethasone (MILD) for refractory lymphoid malignancies: a pilot study.
Neoplasms
Adipocytes cause leukemia cell resistance to L-asparaginase via release of glutamine.
Neoplasms
Amino acid content of L5178Y and L5178Y/L-ASE cells after L-asparaginase treatment.
Neoplasms
Amino acid depletion triggered by ?-asparaginase sensitizes MM cells to carfilzomib by inducing mitochondria ROS-mediated cell death.
Neoplasms
Anticancer activity of fungal L-asparaginase conjugated with zinc oxide nanoparticles.
Neoplasms
Antilymphoma activity of L-asparaginase in vivo: clearance rates of enzyme preparations from guinea pig serum and yeast in relation to their effect on tumor growth.
Neoplasms
Antitumor activity of L-asparaginase from Cylindrocarpon obtusisporum MB-10 and its effect on the immune system.
Neoplasms
Asparagine Depletion Potentiates the Cytotoxic Effect of Chemotherapy Against Brain Tumors.
Neoplasms
Asparagine plays a critical role in regulating cellular adaptation to glutamine depletion.
Neoplasms
Bacterial l-asparaginases for cancer therapy: Current knowledge and future perspectives.
Neoplasms
Biochemical method of cancer control. L-asparaginase in cancer chemotherapy. A review.
Neoplasms
Bioprocess development for L-asparaginase production by Streptomyces rochei, purification and in-vitro efficacy against various human carcinoma cell lines.
Neoplasms
Cell-based laboratory evaluation of coagulation activation by antineoplastic drugs for the treatment of lymphoid tumors.
Neoplasms
Cerebrovascular complications of L-asparaginase in the therapy of acute lymphoblastic leukemia.
Neoplasms
Changes in hemopoiesis of mice of the C3H strain following transplantation of Gardner lymphosarcoma and infection with LDH-virus. III. Blood proteins.
Neoplasms
Characterization and optimization of extracellular L-Asparaginase production by selected Actinomycete strain isolated from an algerian wheat bran.
Neoplasms
Characterization of inhibitors acting at the synthetase site of Escherichia coli asparagine synthetase B.
Neoplasms
Chemical modification by polyethylene glycol of the anti-tumor enzyme arginine deiminase from Mycoplasma arginini.
Neoplasms
Chemical modification of L-asparaginase from Cladosporium sp. for improved activity and thermal stability.
Neoplasms
Chemotherapy versus chemotherapy with intralymphatic tumor cell vaccine in canine lymphoma.
Neoplasms
Childhood non-Hodgkin's lymphoma--results of treatment with ALL high-risk protocol.
Neoplasms
Clinical results of treatment with E. coli L-asparaginase in adults with leukemia, lymphoma, and solid tumors.
Neoplasms
Cloning and expression of L-asparaginase from Bacillus tequilensis PV9W and therapeutic efficacy of Solid Lipid Particle formulations against cancer.
Neoplasms
Combination therapy of animal tumors with L-asparaginase and antagonists of glutamine or glutamic acid.
Neoplasms
Comparative proteomic analysis reveals metabolic variability of probiotic Enterococcus durans during aerobic and anaerobic cultivation.
Neoplasms
Comparison of antitumor effect of recombinant L-asparaginase with wild type one in vitro and in vivo.
Neoplasms
Comparison of glycine metabolism in mouse lymphoma cells either sensitive or resistant to L-asparaginase.
Neoplasms
Concentrations of free amino acids and other blood components in a lymphoma patient during intensive hemodialysis.
Neoplasms
Confinement of Therapeutic Enzymes in Selectively Permeable Polymer Vesicles by Polymerization-Induced Self-Assembly (PISA) Reduces Antibody Binding and Proteolytic Susceptibility.
Neoplasms
Conventional-Vincristine Sulfate vs. Modified Protocol of Vincristine Sulfate and L-Asparaginase in Canine Transmissible Venereal Tumor.
Neoplasms
Critical overview of the main features and techniques used for the evaluation of the clinical applicability of L-asparaginase as a biopharmaceutical to treat blood cancer.
Neoplasms
Crystal structure of Escherichia coli L-asparaginase, an enzyme used in cancer therapy.
Neoplasms
Deamination of glutamine is a prerequisite for optimal asparagine deamination by asparaginases in vivo (CCG-1961).
Neoplasms
Decreasing the immunogenicity of Erwinia chrysanthemi asparaginase via protein engineering: computational approach.
Neoplasms
Delayed-type hypersensitivity in response to L-asparaginase in a case of acute lymphoblastic leukemia.
Neoplasms
Design of expert guided investigation of native L-asparaginase encapsulated long-acting cross-linker-free poly (lactic-co-glycolic) acid nanoformulation in an Ehrlich ascites tumor model.
Neoplasms
Determinants of response to daratumumab in Epstein-Barr virus-positive natural killer and T-cell lymphoma.
Neoplasms
Determination of the maximum tolerated dose of idarubicin when used in a combination chemotherapy program of reinduction of childhood ALL at first marrow relapse and a preliminary assessment of toxicity compared to that of daunorubicin: a report from the Childrens Cancer Study Group.
Neoplasms
Development of L-Asparaginase Biobetters: Current Research Status and Review of the Desirable Quality Profiles.
Neoplasms
Dietary thiamine influences l-asparaginase sensitivity in a subset of leukemia cells.
Neoplasms
E. coli L-asparaginase in the treatment of leukemia and solid tumors in 131 children.
Neoplasms
Effect of L-asparaginase (NSC-109,229) on transplantable and spontaneous tumors from mice and rats.
Neoplasms
Effect of vitreoscilla hemoglobin and culture conditions on production of bacterial L-asparaginase, an oncolytic enzyme.
Neoplasms
Effect of Vitreoscilla hemoglobin on production of a chemotherapeutic enzyme, L-asparaginase, by Pseudomonas aeruginosa.
Neoplasms
Effective dose of L-asparaginase for induction of remission in previously treated children with acute lymphocytic leukemia: a report from Childrens Cancer Study Group.
Neoplasms
Effects of L-asparaginase on plasma amino acid profiles and tumor burden in cats with lymphoma.
Neoplasms
Effects of L-asparaginase on the two cases of acute leukemia with mediastinal tumors as initial signs.
Neoplasms
Eighth new drug seminar on l-asparaginase and daunorubicin. Division of Cancer Treatment. National Cancer Institute. December 17, 1979 Bethesda, Maryland.
Neoplasms
Elucidation of the specific function of the conserved threonine triad responsible for human L-asparaginase autocleavage and substrate hydrolysis.
Neoplasms
Enhancement of metastases by L-asparaginase in allogeneic and isogeneic mouse tumor systems.
Neoplasms
Expression of Asparagine Synthetase Predicts in vitro Response to L-asparaginase in Canine Lymphoid Cell Lines.
Neoplasms
Expression of CD203c on basophils as a marker of immunoglobulin E-mediated l-asparaginase allergy.
Neoplasms
Genistein enhances the effects of L-asparaginase on inducing cell apoptosis in human leukemia cancer HL-60 cells.
Neoplasms
Genotoxic activity of L-asparaginase produced by Streptomyces ansochromogenes UFPEDA 3420.
Neoplasms
Glutaminase Activity of L-Asparaginase Contributes to Durable Preclinical Activity against Acute Lymphoblastic Leukemia.
Neoplasms
High-dose cytosine arabinoside and L-asparaginase in refractory acute lymphoblastic leukemia: the Children's Cancer Group experience.
Neoplasms
Hypersensitivity reactions associated with L-asparaginase administration in 142 dogs and 68 cats with lymphoid malignancies: 2007-2012.
Neoplasms
Identification and structural analysis of an L-asparaginase enzyme from guinea pig with putative tumor cell killing properties.
Neoplasms
Immunity to the 6C3HED ascites tumor following treatment of tumor-bearing mice with Escherichia coli L-asparaginase.
Neoplasms
In vitro immune monitoring of antibody response in dogs given chemoimmunotherapy for lymphoma.
Neoplasms
Influence of L-asparaginase on antibody production and growth of tumors in allogeneic mice.
Neoplasms
Inhibition of GCN2 sensitizes ASNS-low cancer cells to asparaginase by disrupting the amino acid response.
Neoplasms
Inhibition of telomerase activity and induction of apoptosis by Rhodospirillum rubrum L-asparaginase in cancer Jurkat cell line and normal human CD4+ T lymphocytes.
Neoplasms
Interaction of the eucaryotic peptide chain initiation factor eIF-4A with the specific elements at the 5'-untranslated sequence of human asparagine synthetase mRNA.
Neoplasms
Isolation and screening of extracellular anticancer enzymes from halophilic and halotolerant bacteria from different saline environments in Iran.
Neoplasms
l -asparaginase Production and Enhancement by Sarocladium strictum: In vitro Evaluation of Anti-Cancerous Properties.
Neoplasms
L-Asparaginase as a single agent in acute lymphocytic leukemia: survey of studies form Childrens Cancer Study Group.
Neoplasms
L-Asparaginase Exerts Neuroprotective Effects in an SH-SY5Y-A53T Model of Parkinson's Disease by Regulating Glutamine Metabolism.
Neoplasms
l-asparaginase induces intrinsic mitochondrial-mediated apoptosis in human gastric adenocarcinoma cells and impedes tumor progression.
Neoplasms
L-asparaginase produced from soil isolates of Pseudomonas aeruginosa shows potent anti-cancer activity on HeLa cells.
Neoplasms
L-asparaginase therapy for leukemia and other malignant neoplasms. Remission in human leukemia.
Neoplasms
L-asparaginase therapy in children with advanced leukemia. The Southwest Cancer Chemotherapy Study Group.
Neoplasms
L-asparaginase therapy with concomitant cranial venous thrombosis: can MRI help avoiding stroke.
Neoplasms
L-asparaginase with methotrexate and dexamethasone is an effective treatment combination in blastic plasmacytoid dendritic cell neoplasm.
Neoplasms
L-asparaginase-induced modulation of methotrexate polyglutamylation in murine leukemia L5178Y.
Neoplasms
L-asparaginase-induced severe necrotizing pancreatitis successfully treated with percutaneous drainage.
Neoplasms
L-Asparaginase: human toxicology and single agent activity in nonleukemic neoplasms.
Neoplasms
L-type amino-acid transporter 1 (LAT1): a therapeutic target supporting growth and survival of T-cell lymphoblastic lymphoma/T-cell acute lymphoblastic leukemia.
Neoplasms
Long-Term Risk of Venous Thromboembolism in Survivors of Childhood Cancer: A Report From the Childhood Cancer Survivor Study.
Neoplasms
Management of Ontario children with acute lymphoblastic leukemia by the Dana-Farber Cancer Institute protocols.
Neoplasms
Marine microbial L-asparaginase: Biochemistry, molecular approaches and applications in tumor therapy and in food industry.
Neoplasms
Metabolic reprogramming of glioblastoma cells by L-asparaginase sensitizes for apoptosis in vitro and in vivo.
Neoplasms
Metabolism of proteins and glycoproteins in tumour bearing mice treated with Aeromonas L-asparaginase.
Neoplasms
Methotrexate-associated lymphoproliferative disorder presenting as extranodal NK/T-cell lymphoma arising in the lungs.
Neoplasms
Molecular Cloning, Biochemical Characterization, and Antitumor Properties of a Novel L-Asparaginase from Synechococcus elongatus PCC6803.
Neoplasms
Molecular dynamics simulations of human L-asparaginase1: Insights into structural determinants of enzymatic activity.
Neoplasms
No impact of high-dose cytarabine and asparaginase as early intensification with intermediate-risk paediatric acute lymphoblastic leukaemia: results of randomized trial TCCSG study L99-15.
Neoplasms
Optimization of aqueous two-phase micellar system for partial purification of L-asparaginase from Penicillium sp. grown in wheat bran as agro-industrial residue.
Neoplasms
Optimizing the dosing schedule of l-asparaginase improves its anti-tumor activity in breast tumor-bearing mice.
Neoplasms
Outcomes of treatment of children and adolescents with recurrent non-Hodgkin's lymphoma and Hodgkin's disease with dexamethasone, etoposide, cisplatin, cytarabine, and l-asparaginase, maintenance chemotherapy, and transplantation: Children's Cancer Group Study CCG-5912.
Neoplasms
Penetration into Cancer Cells via Clathrin-Dependent Mechanism Allows L-Asparaginase from Rhodospirillum rubrum to Inhibit Telomerase.
Neoplasms
Perfusion trials with a collagen-immobilized enzyme in an extracorporeal reactor: activity, stability, and biocompatibility.
Neoplasms
Phase I evaluation of succinylated Acinetobacter glutaminase-asparaginase in adults.
Neoplasms
Polyethylene glycol acts as a mechanistic stabilizer of L-asparaginase: a computational probing.
Neoplasms
Postinduction Dexamethasone and Individualized Dosing of Escherichia Coli L-Asparaginase Each Improve Outcome of Children and Adolescents With Newly Diagnosed Acute Lymphoblastic Leukemia: Results From a Randomized Study--Dana-Farber Cancer Institute ALL Consortium Protocol 00-01.
Neoplasms
Potential of Anti-Cancer Activity of Secondary Metabolic Products from Marine Fungi.
Neoplasms
Preliminary in vivo evaluation of the protein transduction domain-modified ATTEMPTS approach in enhancing asparaginase therapy.
Neoplasms
Process development for scale-up production of a therapeutic L-asparaginase by Streptomyces brollosae NEAE-115 from shake flasks to bioreactor.
Neoplasms
Production, purification, characterization, antioxidant and antiproliferative activities of extracellular L-asparaginase produced by Fusarium equiseti AHMF4.
Neoplasms
Prolonged second remissions in childhood acute lymphocytic leukemia: a report from the Childrens Cancer Study Group.
Neoplasms
Promoter demethylation of the asparagine synthetase gene is required for ATF4-dependent adaptation to asparagine depletion.
Neoplasms
Purification and biotechnological applications of L-asparaginase from newly isolated Bacillus halotolerans OHEM18 as antitumor and antioxidant agent.
Neoplasms
Purification, characterization and immunogenicity assessment of glutaminase free L-asparaginase from Streptomyces brollosae NEAE-115.
Neoplasms
Purification, characterization, cytotoxicity and anticancer activities of L-asparaginase, anti-colon cancer protein, from the newly isolated alkaliphilic Streptomyces fradiae NEAE-82.
Neoplasms
Randomized phase II comparison of methotrexate with or without L-asparaginase in non-small cell cancer of the lung.
Neoplasms
Rational engineering of L-asparaginase reveals importance of dual activity for cancer cell toxicity.
Neoplasms
Recent developments in l-asparaginase discovery and its potential as anticancer agent.
Neoplasms
Red blood cell-encapsulated L-asparaginase: potential therapy of patients with asparagine synthetase deficient acute myeloid leukemia.
Neoplasms
Reduction in immunogenicity and clearance rate of Escherichia coli L-asparaginase by modification with monomethoxypolyethylene glycol.
Neoplasms
Regeneration, tumor, dietary, and L-asparaginase effects on asparagine biosynthesis in rat liver.
Neoplasms
Sequential combination of high dose methotrexate and L-asparaginase followed by allogeneic transplantation: a first line strategy for CD4+CD56+ hematodermic neoplasm.
Neoplasms
Serial Ultrasound Monitoring for Early Recognition of Asparaginase Associated Pancreatitis in Children with Acute Lymphoblastic Leukemia.
Neoplasms
Serious neutropenia in ALL patients treated with L-asparaginase may be avoided by therapeutic monitoring of the enzyme activity in the circulation.
Neoplasms
SOX12 promotes colorectal cancer cell proliferation and metastasis by regulating asparagine synthesis.
Neoplasms
Studies on the mechanism of tumor inhibition by L-asparaginase. Effects of the enzyme on asparagine levels in the blood, normal tissues, and 6C3HED lymphomas of mice: differences in asparagine formation and utilization in asparaginase-sensitive and -resistant lymphoma cells.
Neoplasms
Studies on the recombinant production and anticancer activity of thermostable L- asparaginase I from Pyrococcus abyssi.
Neoplasms
Successful treatment with Erwinia L-asparaginase for recurrent natural killer/T cell lymphoma.
Neoplasms
The chemical modification of E. coli L-asparaginase by N,O-carboxymethyl chitosan.
Neoplasms
The effects of L-asparaginase on the amino acid incorporation of mouse lymphoid tumors.
Neoplasms
The inhibition of glutamine synthetase sensitizes human sarcoma cells to L-asparaginase.
Neoplasms
The potential of halophilic and halotolerant bacteria for the production of antineoplastic enzymes: L-asparaginase and L-glutaminase.
Neoplasms
The synthesis and degradation of presumptive messenger RNA in cultured mouse leukemia cells during the inhibition of protein synthesis.
Neoplasms
Therapeutic Assessment of Targeting ASNS Combined with l-Asparaginase Treatment in Solid Tumors and Investigation of Resistance Mechanisms.
Neoplasms
Therapy of a murine lymphoma with tumor-specific antiserum in combination with adriamycin, cyclophosphamide, or L-asparaginase.
Neoplasms
Therapy of refractory adult acute lymphoblastic leukemia with vincristine and prednisone plus tandem methotrexate and L-asparaginase. Results of a Cancer and Leukemia Group B Study.
Neoplasms
Venous thromboembolism following L-asparaginase treatment for lymphoid malignancies in Korea.
Neoplasms
Venous thromboembolism in patients with acute leukemia, lymphoma, and multiple myeloma.
Neoplasms
Yarrowia lipolytica L-asparaginase inhibits the growth and migration of lung (A549) and breast (MCF7) cancer cells.
Neoplasms
[Acute pancreatitis during chemotherapy of acute lymphoblastic leukaemia complicated with pseudocyst]
Neoplasms
[Antitumor activity of L-asparaginase from Erwinia carotovora from against different leukemic and solid tumours cell lines].
Neoplasms
[Binding of the antileukemia drug Escherichia coli L-asparaginase to the plasma membrane of normal human mononuclear cells]
Neoplasms
[Cellular test system for studying the biological properties of preparations with L-asparaginase activity]
Neoplasms
[Comparative pharmacokinetic study of two different ways of using L-asparaginase as the main drug in combination chemotherapy]
Neoplasms
[Cytostatic effects of L-asparaginase on models of sensitive and resistant tumors]
Neoplasms
[Effective combination chemotherapy with rituximab for acute lymphoblastic leukemia with bone relapse after bone marrow transplantation]
Neoplasms
[Experimenting with the use of L-asparaginase in the treatment of neoplasms of the blood system]
Neoplasms
[In vitro studies using E. coli L-asparaginase on lymphatic cells of bovine leukemia and various transplantation tumors]
Neoplasms
[Nutritional requirement of cancer cells: inhibition of the growth of cancer cells by L-asparaginase]
Neoplasms
[Results of the treatment of adult acute lymphoblastic leukemia according to ALL-2005 protocol as a basis for new trials]
Neoplasms
[Significance of L-asparaginase activity and biochemical parameters evaluation in children with acute lymphoblastic leukemia]
Neoplasms
[Successful treatment with L-asparaginase-based combination chemotherapy for refractory T-cell post-transplant lymphoproliferative disorder]
Neoplasms
[Superior sagittal sinus thrombosis during remission induction therapy for acute lymphoblastic leukemia]
Neoplasms
[To what extent L-asparaginase affects the tumor cells? Press information of the Sektion Onkologie der Paul-Ehrlich-Gesellschaft für Chemotherapie]
Nephritis
Biochemical criteria for the evaluation of drug efficiency on adjuvant arthritis and nephrotoxic serum nephritis in the rat: studies with phenylbutazone, L-Asparaginase, colchicine, lysine acetylsalicylate, and pyridinol carbamate.
Nephritis
[Use of L-asparaginase in the treatment of patients with nephritis due to lupus: immediate and midterm effects]
Nephrotic Syndrome
Risk factors for the development of hospital-acquired pediatric venous thromboembolism-Dealing with potentially causal and confounding risk factors using a directed acyclic graph (DAG) analysis.
Neurotoxicity Syndromes
L-asparaginase fatal toxic encephalopathy during consolidation treatment in an adult with acute lymphoblastic leukemia.
Neutropenia
Neutropenia associated with vincristine and L-asparaginase induction chemotherapy for canine lymphoma.
Neutropenia
Serious neutropenia in ALL patients treated with L-asparaginase may be avoided by therapeutic monitoring of the enzyme activity in the circulation.
Obesity
Adipocytes cause leukemia cell resistance to L-asparaginase via release of glutamine.
Obesity
Long-Term Risk of Venous Thromboembolism in Survivors of Childhood Cancer: A Report From the Childhood Cancer Survivor Study.
Osteonecrosis
Avascular necrosis of bone after adult acute lymphocytic leukemia treatment with methotrexate, vincristine, L-asparaginase, and dexamethasone (MOAD).
Osteonecrosis
Osteonecrosis of vertebrae in a child with acute lymphocytic leukaemia during L-asparaginase therapy.
Osteosarcoma
The inhibition of glutamine synthetase sensitizes human sarcoma cells to L-asparaginase.
Ovarian Neoplasms
A phase II clinical trial of polyethylene glycol-conjugated L-asparaginase in patients with advanced ovarian cancer: Early closure for safety.
Ovarian Neoplasms
Asparagine synthetase as a causal, predictive biomarker for L-asparaginase activity in ovarian cancer cells.
Ovarian Neoplasms
Asparagine synthetase is a predictive biomarker of L-asparaginase activity in ovarian cancer cell lines.
Ovarian Neoplasms
Integrating data on DNA copy number with gene expression levels and drug sensitivities in the NCI-60 cell line panel.
Ovarian Neoplasms
L-Asparaginase Inhibits Invasive And Angiogenic Activity And Induces Autophagy In Ovarian Cancer.
Ovarian Neoplasms
Searching for pharmacogenomic markers: the synergy between omic and hypothesis-driven research.
Ovarian Neoplasms
[Cellular test system for studying the biological properties of preparations with L-asparaginase activity]
Overweight
Prevalence of transient hyperglycemia during induction chemotherapy for pediatric acute lymphoblastic leukemia.
Pancreatic Pseudocyst
Delayed pancreatic pseudocyst formations. Long-term complication of L-asparaginase treatment.
Pancreatic Pseudocyst
Diabetic ketoacidosis and persistent hyperglycemia as long-term complications of L-asparaginase-induced pancreatitis.
Pancreatic Pseudocyst
Endoscopic ultrasound-guided cystogastrostomy for successful drainage of pancreatic pseudocyst: a pediatric case report.
Pancreatic Pseudocyst
Pancreatic pseudocyst complicating treatment of acute lymphoblastic leukemia.
Pancreatic Pseudocyst
[A case of acute lymphocytic leukemia complicated with multiple pancreatic pseudocysts probably caused by L-asparaginase]
Pancreatic Pseudocyst
[A case of ALL complicated with acute pancreatitis and pancreatic pseudocyst caused by L-asparaginase ]
Pancreatitis
A pilot study evaluating changes in pancreatic lipase immunoreactivity concentrations in canines treated with L-asparaginase (ASNase), vincristine, or both for lymphoma.
Pancreatitis
Acid-suppressing Drugs and a Low 1 Level of Antithrombin as Risk Factors for L-Asparaginase-associated Pancreatitis: A Case-control Study in the Japan Association of Childhood Leukemia Study (JACLS).
Pancreatitis
Acute haemorrhagic pancreatitis following L-asparaginase therapy in acute lymphoblastic leukaemia --a case report.
Pancreatitis
Acute Pancreatitis and Diabetic Ketoacidosis following L-Asparaginase/Prednisone Therapy in Acute Lymphoblastic Leukemia.
Pancreatitis
Acute pancreatitis in association with L-asparaginase therapy: report of one case.
Pancreatitis
Acute Pancreatitis in Children With Acute Lymphoblastic Leukemia After Chemotherapy.
Pancreatitis
Acute Pancreatitis in Children With Acute Lymphoblastic Leukemia Treated With L-Asparaginase.
Pancreatitis
An open-label, multicenter study of polyethylene glycol-L-asparaginase for the treatment of acute lymphoblastic leukemia.
Pancreatitis
Asparaginase treatment side-effects may be due to genes with homopolymeric Asn codons (Review-Hypothesis).
Pancreatitis
Asparaginase-associated pancreatitis is not predicted by hypertriglyceridemia or pancreatic enzyme levels in children with acute lymphoblastic leukemia.
Pancreatitis
Asparagine Synthetase Is Highly Expressed at Baseline in the Pancreas Through Heightened PERK Signaling.
Pancreatitis
Concurrent diabetic ketoacidosis and pancreatitis in Paediatric acute lymphoblastic leukemia receiving L-asparaginase.
Pancreatitis
Delayed pancreatic pseudocyst formations. Long-term complication of L-asparaginase treatment.
Pancreatitis
Diabetes mellitus and pancreatitis as a complication of L-asparaginase therapy.
Pancreatitis
Endoscopic ultrasound-guided cystogastrostomy for successful drainage of pancreatic pseudocyst: a pediatric case report.
Pancreatitis
Epileptic seizures after octreotide administration in a 6.5-year-old female with ALL and L-asparaginase associated pancreatitis: a possible drug interaction.
Pancreatitis
Hyperglycemia induced by chemotherapeutic agents used in acute lymphoblastic leukemia: report of three cases.
Pancreatitis
Hypersensitivity reactions to L-asparaginase do not impact on the remission duration of adults with acute lymphoblastic leukemia.
Pancreatitis
Increased serum trypsin and elastase-1 levels in patients undergoing L-asparaginase therapy.
Pancreatitis
L-asparaginase (Leunase) induced pancreatitis in childhood acute lymphoblastic leukemia.
Pancreatitis
L-asparaginase-induced pancreatic injury is associated with an imbalance in plasma amino acid levels.
Pancreatitis
L-asparaginase-induced severe acute pancreatitis in an adult with extranodal natural killer/T-cell lymphoma, nasal type: A case report and review of the literature.
Pancreatitis
L-asparaginase-induced severe necrotizing pancreatitis successfully treated with percutaneous drainage.
Pancreatitis
l-asparaginase: an effective agent in the treatment of acute lymphoblastic leukemia.
Pancreatitis
Latent onset of clinical pancreatitis in children receiving L-asparaginase therapy.
Pancreatitis
Minimal contribution of severe hypertriglyceridemia in L-asparaginase-associated pancreatitis developed in a child with acute lymphocytic leukemia.
Pancreatitis
Monolith and coating enzymatic microreactors of l-asparaginase: kinetics study by MCE-LIF for potential application in acute lymphoblastic leukemia (ALL) treatment.
Pancreatitis
Pancreatic panniculitis caused by L-asparaginase induced acute pancreatitis in a child with acute lymphoblastic leukemia.
Pancreatitis
Polyethylene glycol-L-asparaginase versus native L-asparaginase in canine non-Hodgkin's lymphoma.
Pancreatitis
Prevention and management of asparaginase/pegasparaginase-associated toxicities in adults and older adolescents: recommendations of an expert panel.
Pancreatitis
Retherapy using L-asparaginase with octreotide in a patient recovering from L-asparaginase-induced pancreatitis.
Pancreatitis
Serial Ultrasound Monitoring for Early Recognition of Asparaginase Associated Pancreatitis in Children with Acute Lymphoblastic Leukemia.
Pancreatitis
Severe L-asparaginase-induced Hypertriglyceridaemia Treated with Plasmapheresis.
Pancreatitis
Successful Management of a Child With Drug-induced Necrotizing Pancreatitis During Acute Lymphoblastic Leukemia Therapy: A Case Report.
Pancreatitis
Successful management of severe L-asparaginase-associated pancreatitis by continuous regional arterial infusion of protease inhibitor and antibiotic.
Pancreatitis
Successful use of octreotide as a chemoprotectant for prevention of PEG-asparaginase-induced pancreatitis.
Pancreatitis
Ureteral obstruction caused by L-asparaginase-induced pancreatitis in a child with acute lymphoblastic leukemia.
Pancreatitis
Use of a synthetic protease inhibitor for the treatment of L-asparaginase-induced acute pancreatitis complicated by disseminated intravascular coagulation.
Pancreatitis
Whole-exome sequencing identified genetic risk factors for asparaginase-related complications in childhood ALL patients.
Pancreatitis
[A case of ALL complicated with acute pancreatitis and pancreatic pseudocyst caused by L-asparaginase ]
Pancreatitis
[Acute pancreatitis during chemotherapy of acute lymphoblastic leukaemia complicated with pseudocyst]
Pancreatitis
[Acute pancreatitis in children with acute lymphoblastic leukemia treated with L-asparaginase]
Pancreatitis
[Delayed acute pancreatitis after treatment with L-asparaginase. A case report]
Pancreatitis
[Significance of L-asparaginase activity and biochemical parameters evaluation in children with acute lymphoblastic leukemia]
Pancreatitis
[Successful readministration of L-asparaginase after development of severe hypertriglyceridemia in a young adult with T-cell acute lymphoblastic leukemia].
Pancreatitis, Acute Hemorrhagic
Successful management with octreotide of a child with L-asparaginase induced hemorrhagic pancreatitis.
Pancreatitis, Acute Necrotizing
Pancreatitis in children: clinical analysis of 61 cases in southern Taiwan.
Panniculitis
Pancreatic panniculitis caused by L-asparaginase induced acute pancreatitis in a child with acute lymphoblastic leukemia.
Paralysis
Acute and sub-acute neurological toxicity in children treated for acute lymphoblastic leukemia.
Paresis
A rare complication in a child undergoing chemotherapy for acute lymphoblastic leukemia: Superior sagittal sinus thrombosis.
Paresis
Intracranial hemorrhage and focal seizures secondary to use of L-asparaginase during induction therapy of acute lymphocytic leukemia.
Paresis
[Neurologic complications during chemotherapy of children with acute lymphoid leukemia]
Parkinson Disease
L-Asparaginase Exerts Neuroprotective Effects in an SH-SY5Y-A53T Model of Parkinson's Disease by Regulating Glutamine Metabolism.
Parotitis
Acute parotitis during induction therapy including L-asparaginase in acute lymphoblastic leukemia.
Parotitis
L-asparaginase induced acute parotitis during intensification therapy of acute lymphoblastic leukemia.
Plasmacytoma
Antitumor effect of hippurate. An experimental study using various mouse tumor strains.
Polycythemia Vera
[L-asparaginase and L-glutaminase activities in leukocytes and plasma in polycythemia vera]
Polyneuropathies
Acute and sub-acute neurological toxicity in children treated for acute lymphoblastic leukemia.
Posterior Leukoencephalopathy Syndrome
Iatrogenic Coagulopathy and the Development of Posterior Reversible Encephalopathy Syndrome after L-asparaginase Chemotherapy.
Posterior Leukoencephalopathy Syndrome
L-asparaginase-induced posterior reversible encephalopathy syndrome during acute lymphoblastic leukemia treatment in children.
Posterior Leukoencephalopathy Syndrome
[Reversible posterior leukoencephalopathy syndrome probably caused by L-asparaginase]
Precursor Cell Lymphoblastic Leukemia-Lymphoma
50 Years Ago in The Journal of Pediatrics: L-Asparaginase Therapy in Pediatric Acute Lymphoblastic Leukemia: Optimizing Efficacy and Minimizing Toxicity.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
A clinically attainable dose of L-asparaginase targets glutamine addiction in lymphoid cell lines.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
A comparison of asparaginase activity in generic formulations of E.coli derived L- asparaginase: In-vitro study and retrospective analysis of asparaginase monitoring in pediatric patients with leukemia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
A comprehensive review on microbial l-asparaginase: Bioprocessing, characterization, and industrial applications.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
A critical analysis of L-asparaginase activity quantification methods-colorimetric methods versus high-performance liquid chromatography.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
A critical review on properties and applications of microbial l-asparaginases.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
A critical risk-benefit assessment argues against the use of anthracyclines in induction regimens for newly diagnosed childhood acute lymphoblastic leukemia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
A dyad of lymphoblastic lysosomal cysteine proteases degrades the antileukemic drug L-asparaginase.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
A fluorometric assay for L-asparaginase activity and monitoring of L-asparaginase therapy.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
A genome-wide view of the in vitro response to l-asparaginase in acute lymphoblastic leukemia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
A Patent Review on the Use of L-asparaginase in the Treatment of Acute Lymphocytic Leukemia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
A pharmacoeconomic analysis of pegaspargase versus native Escherichia coli L-asparaginase for the treatment of children with standard-risk, acute lymphoblastic leukemia: the Children's Cancer Group study (CCG-1962).
Precursor Cell Lymphoblastic Leukemia-Lymphoma
A Phase 2 study of L-asparaginase encapsulated in erythrocytes in elderly patients with Philadelphia chromosome negative acute lymphoblastic leukemia: The GRASPALL/GRAALL-SA2-2008 study.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
A potential type-II L-asparaginase from marine isolate Bacillus australimaris NJB19: Statistical optimization, in silico analysis and structural modeling.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
A prospective cohort study determining the prevalence of thrombotic events in children with acute lymphoblastic leukemia and a central venous line who are treated with L-asparaginase: results of the Prophylactic Antithrombin Replacement in Kids with Acute Lymphoblastic Leukemia Treated with Asparaginase (PARKAA) Study.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
A Randomized Phase I Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of Recombinant Erwinia Asparaginase (JZP-458) in Healthy Adult Volunteers.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
A rare complication in a child undergoing chemotherapy for acute lymphoblastic leukemia: Superior sagittal sinus thrombosis.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
A regimen for antithrombin III substitution in patients with acute lymphoblastic leukemia under treatment with L-asparaginase.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
A syndrome of thrombosis and hemorrhage complicating L-asparaginase therapy for childhood acute lymphoblastic leukemia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
A Young Boy with L-asparaginase-Induced Seizure.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Acid-suppressing Drugs and a Low 1 Level of Antithrombin as Risk Factors for L-Asparaginase-associated Pancreatitis: A Case-control Study in the Japan Association of Childhood Leukemia Study (JACLS).
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Acute central nervous system complications and ammonium levels in adult patients with acute lymphoblastic leukemia receiving l-asparaginase.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Acute leukemia in pregnancy: transient neonatal myelosuppression after combination chemotherapy in the mother.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Acute lymphoblastic leukemia in Chinese adults in Hong Kong.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Acute Pancreatitis and Diabetic Ketoacidosis following L-Asparaginase/Prednisone Therapy in Acute Lymphoblastic Leukemia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Acute pancreatitis in association with L-asparaginase therapy: report of one case.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Acute Pancreatitis in Children With Acute Lymphoblastic Leukemia After Chemotherapy.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Acute Pancreatitis in Children With Acute Lymphoblastic Leukemia Treated With L-Asparaginase.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Acute parotitis during induction therapy including L-asparaginase in acute lymphoblastic leukemia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Addition of rubidomycin to induction treatment with vincristine, prednisone, and L-asparaginase in standard-risk childhood acute lymphocytic leukemia (study ALL V): a report on behalf of the Dutch Childhood Leukemia Study Group.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Adipocytes cause leukemia cell resistance to L-asparaginase via release of glutamine.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Aggressive treatment improves survival in adult acute lymphoblastic leukemia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Allergic reactions and antiasparaginase antibodies in children with high-risk acute lymphoblastic leukemia: A children's oncology group report.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Allergic reactions to E. coli L-asparaginase do not affect outcome in childhood B-precursor acute lymphoblastic leukemia: a Children's Oncology Group Study.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Alternative algorithm for L-asparaginase allergy in children with acute lymphoblastic leukemia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Amino Acid Degrading Enzymes and Autophagy in Cancer Therapy.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Amino acid deprivation using enzymes as a targeted therapy for cancer and viral infections.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
An analytical quality by design (aQbD) approach for a L-asparaginase activity method.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
An experience with plasma exhcange treatment of acute lymphoblastic leukemia in a case with fulminant hepatitis related to l-asparaginase.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
An open-label, multicenter study of polyethylene glycol-L-asparaginase for the treatment of acute lymphoblastic leukemia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Analytical validation of a microplate reader-based method for the therapeutic drug monitoring of L-asparaginase in human serum.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Anaphylactic reaction to polyethylene-glycol conjugated-asparaginase: premedication and desensitization may not be sufficient.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Anaphylaxis to L-asparaginase during treatment for acute lymphoblastic leukemia in children--evidence of a complement-mediated mechanism.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Anticoagulation treatment and prophylactic edoxaban for cerebral sinus venous thrombosis in an adolescent with acute lymphoblastic leukemia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Antiproliferative effects of L-asparaginase in acute myeloid leukemia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Antithrombin and fibrinogen levels as predictors for plasma L-asparaginase activity in children with acute lymphoblastic leukemia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Antithrombin III as the Indicator of L-Asparaginase Activity in Children Treated for Acute Lymphoblastic Leukemia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Antithrombin supplementation III in childhood acute lymphoblastic leukemia treated with L-asparaginase.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Asparaginase (native ASNase or pegylated ASNase) in the treatment of acute lymphoblastic leukemia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Asparaginase and methotrexate combination chemotherapy in relapsed acute lymphoblastic leukemia in adults.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Asparaginase pharmacokinetics after intensive polyethylene glycol-conjugated L-asparaginase therapy for children with relapsed acute lymphoblastic leukemia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Asparaginase-associated pancreatitis is not predicted by hypertriglyceridemia or pancreatic enzyme levels in children with acute lymphoblastic leukemia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Asparaginase-induced hepatotoxicity: rapid development of cholestasis and hepatic steatosis.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Asparagine and aspartic acid concentrations in bone marrow versus peripheral blood during BFM-based induction therapy for childhood acute lymphoblastic leukemia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Asparagine synthetase as a causal, predictive biomarker for L-asparaginase activity in ovarian cancer cells.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Asparagine synthetase expression is linked with L-asparaginase resistance in TEL-AML1-negative but not TEL-AML1-positive pediatric acute lymphoblastic leukemia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Asparagine: A Metabolite to Be Targeted in Cancers.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Assessment of l-Asparaginase Pharmacodynamics in Mouse Models of Cancer.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Association of delivered drug dose and outcome for children with acute lymphoblastic leukemia and unfavorable presenting features.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Attenuation of asparaginase-induced hyperglycemia after substitution of the Erwinia carotovora for the Escherichia coli enzyme preparation.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Autophagy inhibition as a potential future targeted therapy for ETV6-RUNX1 driven B-cell precursor acute lymphoblastic leukemia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Autophagy is required for cell survival under L-asparaginase-induced metabolic stress in acute lymphoblastic leukemia cells.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Avascular necrosis of bone after adult acute lymphocytic leukemia treatment with methotrexate, vincristine, L-asparaginase, and dexamethasone (MOAD).
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Biological characteristics and prognostic value of in vitro three-drug resistance to prednisolone, L-asparaginase, and vincristine in childhood acute lymphoblastic leukemia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Biophysical characterization of two commercially available preparations of the drug containing Escherichia coli L-Asparaginase 2.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Bone marrow necrosis and thrombotic complications in childhood acute lymphoblastic leukemia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
CD7 positive acute lymphoblastic leukemia successfully treated with high dose cytosine arabinoside and mitoxantrone: a case report.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Cell-penetrating peptides meditated encapsulation of protein therapeutics into intact red blood cells and its application.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Cerebral infarction in a patient with acute lymphoblastic leukemia after fresh-frozen plasma replacement during L-asparaginase therapy.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Cerebral Thrombotic Complications Related to l-Asparaginase Treatment for Acute Lymphoblastic Leukemia: Retrospective Review of 10 Cases.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Cerebral venous thrombosis in adult patients with acute lymphoblastic leukemia or lymphoblastic lymphoma during induction chemotherapy with l-asparaginase: The GRAALL experience.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Cerebrospinal fluid proteomics in children during induction for acute lymphoblastic leukemia: A pilot study.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Cerebrovascular complications in cancer patients.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Cerebrovascular complications of L-asparaginase in the therapy of acute lymphoblastic leukemia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Cerebrovascular complications of L-asparaginase therapy in children with leukemia: aphasia and other neuropsychological deficits.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Cerebrovascular complications of L-asparaginase therapy.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Changes in antithrombin and fibrinogen levels during induction chemotherapy with L-asparaginase in adult patients with acute lymphoblastic leukemia or lymphoblastic lymphoma. Use of supportive coagulation therapy and clinical outcome: the CAPELAL study.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Changes in hemostatic and fibrinolytic proteins in patients receiving L-asparaginase therapy.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Changes of hemostatic factors in children with acute lymphoblastic leukemia receiving combined chemotherapy including high dose methylprednisolone and L-asparaginase.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Characteristics of Blood Transfusion During Induction Remission in Children With Acute Lymphoblastic Leukemia: A Single-Center Retrospective Investigation.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Characterization of a novel asparaginase from soil metagenomic libraries generated from forest soil.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Characterization of a recombinant glutaminase-free L-asparaginase (ansA3) enzyme with high catalytic activity from Bacillus licheniformis.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Characterization of hypertriglyceridemia induced by L-asparaginase therapy for acute lymphoblastic leukemia and malignant lymphoma.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Chemical metabolic inhibitors for the treatment of blood-borne cancers.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Chemotherapy and its effect on testicular morphology in children.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Childhood blastic NK cell leukemia successfully treated with L-asparagenase and allogeneic bone marrow transplantation.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Circumventing the side effects of L-asparaginase.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Clinical characteristics of Japanese patients with severe hypertriglyceridemia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Clinical effect of imatinib added to intensive combination chemotherapy for newly diagnosed Philadelphia chromosome-positive acute lymphoblastic leukemia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Clinical utility of ammonia concentration as a diagnostic test in monitoring of the treatment with L-asparaginase in children with acute lymphoblastic leukemia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Cloning and characterization of Halomonas elongata L-asparaginase, a promising chemotherapeutic agent.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Coagulation abnormalities in childhood acute lymphoblastic leukemia: assessing the impact of L-asparaginase therapy in Ghana.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Coagulopathic side effect of L-asparaginase on fibrinogen level in childhood acute lymphoblastic leukemia during induction phase.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Combination chemotherapy for bone marrow relapse in childhood lymphoblastic leukaemia (ALL).
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Combination chemotherapy for children with acute lymphocytic leukemia who fail to respond to standard remission-induction therapy.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Combination therapy of omega-3 fatty acids and acipimox for children with hypertriglyceridemia and acute lymphoblastic leukemia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Comparative pharmacokinetic studies of three asparaginase preparations.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Comparison of the therapeutic response of patients with childhood acute lymphoblastic leukemia in relapse to vindesine versus vincristine in combination with prednisone and L-asparaginase: a phase III trial.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Comprehensive analysis of dose intensity of acute lymphoblastic leukemia chemotherapy.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Concomitant Use of Acyclovir and Intravenous Immunoglobulin Rescues an Immunocompromised Child With Disseminated Varicella Caused Multiple Organ Failure.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Concurrent diabetic ketoacidosis and pancreatitis in Paediatric acute lymphoblastic leukemia receiving L-asparaginase.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Consensus expert recommendations for identification and management of asparaginase hypersensitivity and silent inactivation.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Consideration of Glucocorticoids and Escherichia coli-derived L-asparaginase in the treatment of pediatric acute lymphoblastic leukemia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Construction of expression systems for Escherichia coli asparaginase II and two-step purification of the recombinant enzyme from periplasmic extracts.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Correction of hemostatic imbalances induced by L-asparaginase therapy in children with acute lymphoblastic leukemia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Correlation of L-asp Activity, Anti-L-asp Antibody, Asn and Gln With Adverse Events Especially Anaphylaxis Risks in PEG-asp-Contained Regime Treated Pediatric ALL Patients.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Critical overview of the main features and techniques used for the evaluation of the clinical applicability of L-asparaginase as a biopharmaceutical to treat blood cancer.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Curcumin potentiates antitumor activity of l-asparaginase via inhibition of the AKT signaling pathway in acute lymphoblastic leukemia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Deamination of glutamine is a prerequisite for optimal asparagine deamination by asparaginases in vivo (CCG-1961).
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Delayed-type hypersensitivity in response to L-asparaginase in a case of acute lymphoblastic leukemia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Design of starch functionalized biodegradable P(MAA-co-MMA) as carrier matrix for l-asparaginase immobilization.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Determination of L-asparaginase activity in serum by thin-layer chromatography: application to the treatment of acute lymphoblastic leukemia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Determination of the maximum tolerated dose of idarubicin when used in a combination chemotherapy program of reinduction of childhood ALL at first marrow relapse and a preliminary assessment of toxicity compared to that of daunorubicin: a report from the Childrens Cancer Study Group.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Development and Validation of a Hydrophilic Interaction Liquid Chromatography Tandem Mass Spectrometry Method for the Determination of Asparagine in Human Serum.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Development of anti-asparaginase antibodies in childhood acute lymphoblastic leukemia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Development of asparaginase Erwinia chrysanthemi for the treatment of acute lymphoblastic leukemia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Development of L-Asparaginase Biobetters: Current Research Status and Review of the Desirable Quality Profiles.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Development of Processes for Recombinant L-Asparaginase II Production by Escherichia coli Bl21 (De3): From Shaker to Bioreactors.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Dexamethasone, methotrexate, ifosfamide, l-asparaginase and etoposide (SMILE) chemotherapy for relapsed or refractory adult lymphoblastic lymphoma.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Diabetic ketoacidosis with L-asparaginase therapy.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Different methodologies for sustainability of optimization techniques used in submerged and solid state fermentation.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Direct long-term effects of L-asparaginase on rat and human pancreatic islets.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Discontinuation of L-asparaginase and poor response to prednisolone are associated with poor outcome of ETV6-RUNX1-positive pediatric B-cell precursor acute lymphoblastic leukemia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Discovery of human-like L-asparaginases with potential clinical use by directed evolution.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Disordered hemostasis associated with severely depressed fibrinolysis demonstrated using a simultaneous thrombin and plasmin generation assay during L-asparaginase induction therapy in pediatric acute lymphoblastic leukemia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Disseminated intravascular coagulation in adult acute lymphoblastic leukemia: frequent complications with fibrinogen levels less than 100 mg/dl.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Distinctive sensitivity of some T-leukemia cell lines to L-asparaginase.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Do immunoglobulin G and immunoglobulin E anti-l-asparaginase antibodies have distinct implications in children with acute lymphoblastic leukemia? A cross-sectional study.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Dynamic changes in specific anti-L-asparaginase antibodies generation during acute lymphoblastic leukemia treatment.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Early diagnosis of asparaginase-associated pancreatitis based on elevated serum elastase-1 levels: Case reports.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Effect of glucocorticoids, E. coli- and Erwinia L-asparaginase on hemostatic proteins in children with acute lymphoblastic leukemia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Effect of L-asparaginase administration on coagulation and platelet function in children with leukemia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Effect of L-asparaginase therapy for acute lymphoblastic leukemia on plasma vitamin K-dependent coagulation factors and inhibitors.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Effect of protracted high-dose L-asparaginase given as a second exposure in a Berlin-Frankfurt-Münster-based treatment: results of the randomized 9102 intermediate-risk childhood acute lymphoblastic leukemia study--a report from the Associazione Italiana Ematologia Oncologia Pediatrica.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Effect of the antileukemic agent L-asparaginase on thyroxine-binding globulin and albumin synthesis in cultured human hepatoma (HEP G2) cells.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Effective combination treatment of advanced acute lymphocytic leukemia with cytosine arabinoside (NSC-63878) and L-asparaginase (NSC-109229).
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Effective dose of L-asparaginase for induction of remission in previously treated children with acute lymphocytic leukemia: a report from Childrens Cancer Study Group.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Effectiveness of rubidomycin in induction therapy with vincristine, prednisone, and L-asparaginase for standard risk childhood acute lymphocytic leukemia: results of a Dutch phase III study (ALL V). A report on behalf of the Dutch Childhood Leukemia Study Group (DCLSG).
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Effects of dose-reduced Medac L-asparaginase on coagulation in trial ALL-BFM 2000.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Effects of the antileukemic drug L-asparaginase on sex hormone-binding globulin: studies in vivo and in vitro.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Efficacy and safety of G-CSF, low-dose cytarabine and aclarubicin in combination with l-asparaginase, prednisone in the treatment of refractory or relapsed acute lymphoblastic leukemia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Efficacy and safety of PEG-asparaginase versus E. coli L-asparaginase in Chinese children with acute lymphoblastic leukemia: a meta-analysis.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Efficacy of daunorubicin in the therapy of adult acute lymphocytic leukemia: a prospective randomized trial by cancer and leukemia group B.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Elimination of l-asparaginase in children treated for acute lymphoblastic leukemia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Endoscopic ultrasound-guided cystogastrostomy for successful drainage of pancreatic pseudocyst: a pediatric case report.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Enhanced catalysis of l-asparaginase from Bacillus licheniformis by a rational redesign.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Enhancement in biological activity of L-asparginase by its conjugation on silica nanoparticles.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Entrapment of L-asparaginase in red blood cells. A strategy to improve treatment of acute lymphoblastic leukemia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Enzymes as agents for the treatment of disease.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Eruptive post-chemotherapy in situ melanomas and dysplastic nevi.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Erwinia- and E. coli-derived L-asparaginase have similar effects on hemostasis. Pilot study in 10 patients with acute lymphoblastic leukemia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Erythrocyte encapsulated l-asparaginase (GRASPA) in acute leukemia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Evaluation of L-asparaginase: polyethylene glycol conjugate versus native L-asparaginase combined with chemotherapy. A randomized double-blind study in canine lymphoma.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Evaluation of the asparagine synthetase level in leukemia cells by monoclonal antibodies.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Evidence of a hypercoagulable state in patients with acute lymphoblastic leukemia treated with low dose of E. coli L-asparaginase: a GIMEMA study.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Experience with generic pegylated L-asparaginase in children with acute lymphoblastic leukemia and monitoring of serum asparaginase activity.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Expression levels of TEL, AML1, and the fusion products TEL-AML1 and AML1-TEL versus drug sensitivity and clinical outcome in t(12;21)-positive pediatric acute lymphoblastic leukemia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Expression of a recombinant bacterial L-asparaginase in human cells.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Expression of Asparagine Synthetase Predicts in vitro Response to L-asparaginase in Canine Lymphoid Cell Lines.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Expression of miR-196b is not exclusively MLL-driven but is especially linked to activation of HOXA genes in pediatric acute lymphoblastic leukemia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Extended Stability of Reconstituted Lyophilized Erwinia L-asparaginase in Vials.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Extracellular production of the oncolytic enzyme, L-asparaginase, by newly isolated Streptomyces sp. strain NEAE-95 as potential microbial cell factories: optimization of culture conditions using response surface methodology.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Factor VIII/von Willebrand factor abnormalities during L-asparaginase treatment in patients with acute lymphoblastic leukemia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Fatal Liver Failure in an Adult Patient with Acute Lymphoblastic Leukemia following Treatment with L-Asparaginase.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Fed-Batch Production of Saccharomyces cerevisiae L-Asparaginase II by Recombinant Pichia pastoris MUT
s
Strain.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Fermentative production and isolation of L-asparaginase from Erwinia carotovora, EC-113.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Fibrinopeptide A changes during remission induction treatment with L-asparaginase in acute lymphoblastic leukemia: evidence for activation of blood coagulation.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Filamentous Fungi Producing l-Asparaginase with Low Glutaminase Activity Isolated from Brazilian Savanna Soil.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Five chinese pediatric patients with leukemias possibly arising from immature natural killer cells: clinical features and courses.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Gene expression of ASNS, LGMN and CTSB is elevated in a subgroup of childhood BCP-ALL with PAX5 deletion.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Genetic inhibition of NFATC2 attenuates asparaginase hypersensitivity in mice.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Genome-wide loss-of-function genetic screening identifies opioid receptor ?1 as a key regulator of L-asparaginase resistance in pediatric acute lymphoblastic leukemia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Genotoxic activity of L-asparaginase produced by Streptomyces ansochromogenes UFPEDA 3420.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Glucose metabolism in children with acute lymphoblastic leukemia treated according to two different L-asparaginase schedules.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Glutaminase activity determines cytotoxicity of L-asparaginases on most leukemia cell lines.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Glutaminase Activity of L-Asparaginase Contributes to Durable Preclinical Activity against Acute Lymphoblastic Leukemia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Glutaminase-free L-asparaginase production by Leucosporidium muscorum isolated from Antarctic marine-sediment.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Granulocyte-Macrophage Colony-Stimulating Factor in Newly Diagnosed Adult Patients with Acute Lymphoblastic Leukemia Treated with Conventional Chemotherapy.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Greater decrease of fibrinogen as compared to antithrombin III in L-asparaginase treated leukemia patients.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Guinea pig serum L-asparaginase: purification, and immunological relationship to liver L-asparaginase and serum L-asparaginases in other mammals.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
HAP1 loss confers l-asparaginase resistance in ALL by downregulating the calpain-1-Bid-caspase-3/12 pathway.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Hemostatic changes in children with acute lymphoblastic leukemia treated according to two different L-asparaginase schedules.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Hepatomegaly and fever at the time of neutrophil recovery revealing L-asparaginase toxicity in the treatment of acute lymphoblastic leukemia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
High-dose cytosine arabinoside and L-asparaginase in refractory acute lymphoblastic leukemia: the Children's Cancer Group experience.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Highly efficient novel recombinant L-asparaginase with no glutaminase activity from a new halo-thermotolerant Bacillus strain.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Highly efficient Pyrococcus furiosus recombinant L-asparaginase with no glutaminase activity: Expression, purification, functional characterization, and cytotoxicity on THP-1, A549 and Caco-2 cell lines.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Histopathological features of L-asparaginase-induced liver disease.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Hypercoagulability during L-asparaginase treatment: the effect of antithrombin III supplementation in vivo.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Hyperglycemia associated with the therapeutic use of L-asparaginase: possible role of insulin receptors.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Hyperglycemia, ketoacidosis and other complications of L-asparaginase in children with acute lymphoblastic leukemia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Hypersensitivity reactions to L-asparaginase do not impact on the remission duration of adults with acute lymphoblastic leukemia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Hypoglycemia associated with L-asparaginase in acute lymphoblastic leukemia treatment: a case report.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Hypomethylation and reactivation of the asparagine synthetase gene induced by L-asparaginase and ethyl methanesulfonate.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Iatrogenic Coagulopathy and the Development of Posterior Reversible Encephalopathy Syndrome after L-asparaginase Chemotherapy.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Idarubicin in the initial treatment of adults with acute lymphoblastic leukemia: the effect of drug schedule on outcome.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Identification of L-asparaginases from Streptomyces strains with competitive activity and immunogenic profiles: a bioinformatic approach.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Immunogenicity of native or pegylated E. coli and Erwinia asparaginases assessed by ELISA and surface plasmon resonance (SPR-biacore) assays of IgG antibodies (Ab) in sera from patients with acute lymphoblastic leukemia (ALL).
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Immunoglobulin and granulocyte cytochemical reactions in L-asparaginase treated children with acute lymphoblastic leukemia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Immunological aspects of L-asparaginase treatment in children with lymphoproliferative disease.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Immunological studies on modified enzymes. I. soluble L-asparaginase/mouse albumin copolymer with enzyme activity and substantial loss of immunogenicity.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Improved treatment results in the management of single and multiple relapses of acute lymphoblastic leukemia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Improving the Treatment of Acute Lymphoblastic Leukemia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
In silico engineering of L-asparaginase to have reduced glutaminase side activity for effective treatment of acute lymphoblastic leukemia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
In silico modelling and molecular dynamics simulation studies on L-Asparaginase isolated from bacterial endophyte of Ocimum tenuiflorum.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
In vitro and in vivo killing of acute lymphoblastic leukemia cells by L-asparaginase.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Inhibition of GCN2 sensitizes ASNS-low cancer cells to asparaginase by disrupting the amino acid response.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Intensive therapy for adult acute lymphoblastic leukemia: preliminary results of the idarubicin/vincristine/L-asparaginase/prednisolone regimen.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Interaction of alpha 2-macroglobulin with L-asparaginase.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Interferences that impact measuring optimal L-asparaginase activity and consequent errors interpreting these data.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Intracranial bleeding during therapy with L-asparaginase in childhood acute lymphocytic leukemia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Intracranial hemorrhage and focal seizures secondary to use of L-asparaginase during induction therapy of acute lymphocytic leukemia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Intravenous PEG-asparaginase during remission induction in children and adolescents with newly diagnosed acute lymphoblastic leukemia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Isolation and identification of actinomycetes for production of novel extracellular glutaminase free L-asparaginase.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Isolation and identification of L-asparaginase-producing endophytic fungi from the Asteraceae family plant species of Iran.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Kinetic studies of L-asparaginase from Penicillium digitatum.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
l -asparaginase Production and Enhancement by Sarocladium strictum: In vitro Evaluation of Anti-Cancerous Properties.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
L-asparaginase (Leunase) induced pancreatitis in childhood acute lymphoblastic leukemia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
L-asparaginase and 6-diazo-5-oxo-L-norleucine synergistically inhibit the growth of glioblastoma cells.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
L-asparaginase and PEG asparaginase--past, present, and future.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
L-Asparaginase and Steroids-associated Hypertriglyceridemia Successfully Treated With Plasmapheresis in a Child With Acute Lymphoblastic Leukemia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
L-Asparaginase and the effect of age on coagulation and fibrinolysis in childhood acute lymphoblastic leukemia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
L-asparaginase and venous thromboembolism in acute lymphocytic leukemia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
L-asparaginase as a marker of chemotherapy dose modification in children with acute lymphoblastic leukemia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
L-Asparaginase as a single agent in acute lymphocytic leukemia: survey of studies form Childrens Cancer Study Group.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
L-Asparaginase delivered by Salmonella typhimurium suppresses solid tumors.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
L-asparaginase doses number as a prognostic factor in childhood acute lymphoblastic leukemia: A survival analysis study.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
L-asparaginase effect on antithrombin-III levels.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
L-Asparaginase encapsulated intact erythrocytes for treatment of acute lymphoblastic leukemia (ALL).
Precursor Cell Lymphoblastic Leukemia-Lymphoma
L-asparaginase fatal toxic encephalopathy during consolidation treatment in an adult with acute lymphoblastic leukemia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
L-asparaginase for treatment of childhood acute lymphoblastic leukemia: what have we learned?
Precursor Cell Lymphoblastic Leukemia-Lymphoma
L-Asparaginase from E. chrysanthemi expressed in glycoswitch®: effect of His-Tag fusion on the extracellular expression.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
L-asparaginase in acute lymphoblastic leukemia treatment: the role of human antithrombin III concentrates in regulating the prothrombotic state induced by therapy.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
L-asparaginase in the treatment of patients with acute lymphoblastic leukemia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
L-asparaginase in treatment of acute leukemia in children.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
L-asparaginase induced acute parotitis during intensification therapy of acute lymphoblastic leukemia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
L-asparaginase induced antithrombin III deficiency: evidence against the production of a hypercoagulable state.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
L-asparaginase induced fatal cortical venous thrombosis in acute lymphoblastic leukemia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
L-asparaginase induced hypoglycemia in a case of acute lymphoblastic leukemia: a patient report.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
L-asparaginase induced intracranial haemorrhage in acute lymphoblastic leukemia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
L-asparaginase induced severe hypertriglyceridemia in acute lymphoblastic leukemia with 11q23 abnormality.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
L-Asparaginase induced thrombosis in acute lymphoblastic leukemia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
L-Asparaginase inhibits the rapamycin-targeted signaling pathway.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
L-Asparaginase Isolated from Phaseolus vulgaris Seeds Exhibited Potent Anti-Acute Lymphoblastic Leukemia Effects In-Vitro and Low Immunogenic Properties In-Vivo.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
L-Asparaginase lowers plasma antithrombin and mannan-binding-lectin levels: Impact on thrombotic and infectious events in children with acute lymphoblastic leukemia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
L-asparaginase pharmacokinetics and asparagine levels in cerebrospinal fluid of rhesus monkeys and humans.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
L-asparaginase Production by Leucosporidium scottii in a Bench-Scale Bioreactor With Co-production of Lipids.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
l-Asparaginase Production by Moderate Halophilic Bacteria Isolated from Maharloo Salt Lake.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
L-asparaginase reinduction and maintenance therapy in previously treated acute lymphocytic leukemia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
L-asparaginase treatment in acute lymphoblastic leukemia: a focus on Erwinia asparaginase.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
L-asparaginase used with cytosine arabinoside in treatment of childhood acute lymphocytic leukemia refractory to vincristine and prednisone.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
L-Asparaginase, vincristine, and prednisone for induction of first remission in acute lymphocytic leukemia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
L-asparaginase-induced abnormality in plasma glucose level in patients of acute lymphoblastic leukemia admitted to a tertiary care hospital of Odisha.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
L-asparaginase-induced antithrombin type I deficiency: implications for conformational diseases.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
L-asparaginase-induced apoptosis in ALL cells involves IP3 receptor signaling.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
L-asparaginase-induced pancreatic injury is associated with an imbalance in plasma amino acid levels.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
L-asparaginase-induced Parotitis in an Elderly Patient with Acute Lymphoblastic Leukemia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
L-asparaginase-induced posterior reversible encephalopathy syndrome during acute lymphoblastic leukemia treatment in children.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
L-asparaginase-induced reversible posterior leukoencephalopathy syndrome in a child with acute lymphoblastic leukemia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
L-asparaginase-induced severe necrotizing pancreatitis successfully treated with percutaneous drainage.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
L-asparaginase: a promising chemotherapeutic agent.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
l-asparaginase: an effective agent in the treatment of acute lymphoblastic leukemia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
L-Asparaginase: Long-Term Results of a Randomized Trial of the Effect of Additional 3 Doses During Consolidation Treatment in the Indonesian WK-ALL-2000 Protocol.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
L-asparagine depletion and L-asparaginase activity in children with acute lymphoblastic leukemia receiving i.m. or i.v. Erwinia C. or E. coli L-asparaginase as first exposure.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
L-Asparagine depletion in plasma and cerebro-spinal fluid of children with acute lymphoblastic leukemia during subsequent exposures to Erwinia L-asparaginase.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
L-Asparagine depletion levels and L-asparaginase activity in plasma of children with acute lymphoblastic leukemia under asparaginase treatment.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
L-asparagine requirements of human T-lymphocytes and B-lymphocytes in culture.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
L-Carnitine for Treatment of Pegasparaginase-Induced Hepatotoxicity.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
L-glutaminase and L-asparaginase by extracorporeal route in acute lymphoblastic leukemia therapy.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Long-term follow-up of treatment and potential cure of adult acute lymphocytic leukemia with MOAD: a non-anthracycline containing regimen.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Long-term outcome of a pediatric-inspired regimen used for adults aged 18-50 years with newly diagnosed acute lymphoblastic leukemia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Long-term outcome of L86 and L97 protocols for adult acute lymphoblastic leukemia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Long-term results of a randomized trial on extended use of high dose L-asparaginase for standard risk childhood acute lymphoblastic leukemia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Low Bioavailability and High Immunogenicity of a New Brand of E. colil-Asparaginase with Active Host Contaminating Proteins.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Low expression of asparagine synthetase in lymphoid blasts precludes its role in sensitivity to L-asparaginase.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Low plasma levels of hemostatic proteins during the induction phase in children with acute lymphoblastic leukemia: A retrospective study by the JACLS. Japan Association of Childhood Leukemia Study.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Lymphoblastic lymphoma in adults: results of a pilot protocol.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Management of hypertriglyceridemia in children with acute lymphoblastic leukemia under persistent therapy with glucocorticoids and L-asparaginase during induction chemotherapy.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Management of L-asparaginase induced prothrombotic state in acute lymphoblastic leukemia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Mapping of B-cell epitopes in E. coli asparaginase II, an enzyme used in leukemia treatment.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Measurement of serum L-asparagine in the presence of L-asparaginase requires the presence of an L-asparaginase inhibitor.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Mechanism of action of L-asparaginase on the cell cycle and growth in acute lymphoblastic leukemia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Medication-induced diabetes during induction treatment for ALL, an early marker for future metabolic risk?
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Meta-analysis and meta-regression analysis to compare the outcomes of chemotherapy for T- and B-lineage acute lymphoblastic leukemia (ALL): the use of dexamethasone, L-asparaginase, and/or methotrexate may improve the outcome of T-lineage ALL.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Metabolic profile of leukemia cells influences treatment efficacy of L-asparaginase.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Microbial enzymes for deprivation of amino acid metabolism in malignant cells: biological strategy for cancer treatment.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Microbial L-asparaginase: purification, characterization and applications.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Microbial production, molecular modification, and practical application of l-Asparaginase: A review.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Minimal contribution of severe hypertriglyceridemia in L-asparaginase-associated pancreatitis developed in a child with acute lymphocytic leukemia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Minimal residual disease (MRD) measurement as a tool to compare the efficacy of chemotherapeutic drug regimens using Escherichia Coli-asparaginase or Erwinia-asparaginase in childhood acute lymphoblastic leukemia (ALL).
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Molecular dynamics simulations of human L-asparaginase1: Insights into structural determinants of enzymatic activity.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Monitoring of Anti-L-Asparaginase Antibody and L-Asparaginase Activity Levels in a Pediatric Patient With Acute Lymphoblastic Leukemia and Hypersensitivity to Native Escherichia coli L-Asparaginase During Desensitization Courses.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Monolith and coating enzymatic microreactors of l-asparaginase: kinetics study by MCE-LIF for potential application in acute lymphoblastic leukemia (ALL) treatment.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Multiple Severe Toxicities of L-Asparaginase and Their Innovative Management during Induction Therapy of Acute Lymphoblastic Leukemia in an Adult Patient.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Myeloid antigen co-expression in childhood acute lymphoblastic leukaemia: relationship with in vitro drug resistance.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Myocardial infarction in a patient with acute lymphoblastic leukemia during L-asparaginase therapy.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Myocardial ischemia in a patient with acute lymphoblastic leukemia during L-asparaginase therapy.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Nation-wide randomized comparative study of doxorubicin, vincristine and prednisolone combination therapy with and without L-asparaginase for adult acute lymphoblastic leukemia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
National Italian Delphi panel consensus: which measures are indicated to minimize pegylated-asparaginase associated toxicity during treatment of adult acute lymphoblastic leukemia?
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Near-haploid cell line in the blastic crisis of chronic myelogenous leukemia: a possible marker for lymphoid malignancy.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Negligible hemostatic toxicity of intermediate-dose Erwinase in adult patients with acute lymphoblastic leukemia: preliminary data.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Non-classical secretion of a type I L-asparaginase in Bacillus subtilis.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Novel site-specific PEGylated L-asparaginase.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Octreotide prevents L-asparaginase-induced pancreatic injury in rats.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Octreotide therapy in asparaginase-associated pancreatitis in childhood acute lymphoblastic leukemia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Ocular complications of sigmoid sinus thrombosis from L-asparaginase.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Optimal use of L-asparaginase (NSC-109229) in acute lymphocytic leukemia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Optimization of aqueous two-phase micellar system for partial purification of L-asparaginase from Penicillium sp. grown in wheat bran as agro-industrial residue.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Optimization of culture conditions and bench-scale production of anticancer enzyme L-asparaginase by submerged fermentation from Aspergillus terreus CCT 7693.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Optimization of Culture Conditions for Production of the Anti-Leukemic Glutaminase Free L-Asparaginase by Newly Isolated Streptomyces olivaceus NEAE-119 Using Response Surface Methodology.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Optimizing pegylated asparaginase use: An institutional guideline for dosing, monitoring, and management.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Outcomes Following Discontinuation of E. coli l-Asparaginase Upon Severe Allergic Reactions in Children With Acute Lymphoblastic Leukemia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Pancreatic panniculitis caused by L-asparaginase induced acute pancreatitis in a child with acute lymphoblastic leukemia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Pancreatic pseudocyst complicating treatment of acute lymphoblastic leukemia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Patient stratification based on prednisolone-vincristine-asparaginase resistance profiles in children with acute lymphoblastic leukemia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Pediatric-inspired regimen with late intensification and increased dose of L-asparaginase for adult acute lymphoblastic leukemia: the KALLA 1406/1407 study.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
PEG-asparaginase allergy in children with acute lymphoblastic leukemia in the NOPHO ALL2008 protocol.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
PEG-asparaginase and native Escherichia coli L-asparaginase in acute lymphoblastic leukemia in children and adolescents: a systematic review.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
PEG-asparaginase in BFM-90 regimen improves outcomes in adults with newly diagnosed lymphoblastic lymphoma.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Penicillium genus as a source for anti-leukemia compounds: an overview from 1984 to 2020.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Perfusion trials with a collagen-immobilized enzyme in an extracorporeal reactor: activity, stability, and biocompatibility.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Pharmacokinetic and pharmacodynamic properties of calaspargase pegol Escherichia coli L-asparaginase in the treatment of patients with acute lymphoblastic leukemia: results from Children's Oncology Group Study AALL07P4.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Pharmacokinetic modeling of an induction regimen for in vivo combined testing of novel drugs against pediatric acute lymphoblastic leukemia xenografts.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Pharmacokinetic, pharmacodynamic and intracellular effects of PEG-asparaginase in newly diagnosed childhood acute lymphoblastic leukemia: results from a single agent window study.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Pharmacokinetics and drug monitoring of L-asparaginase treatment.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Pharmacokinetics of Erwinia asparaginase after intravenous and intramuscular administration.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Pharmacological and clinical evaluation of L-asparaginase in the treatment of leukemia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Pharmacological inhibition of fatty-acid oxidation synergistically enhances the effect of l-asparaginase in childhood ALL cells.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Pharmacology, immunogenicity, and efficacy of a novel pegylated recombinant Erwinia chrysanthemi-derived L-asparaginase.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Poly (lactic-co-glycolic acid) nanospheres allow for high l-asparaginase encapsulation yield and activity.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Poly(2-vinyl-4,4-dimethylazlactone)-functionalized magnetic nanoparticles as carriers for enzyme immobilization and its application.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Polyethylene Glycol-conjugated L-asparaginase versus native L-asparaginase in combination with standard agents for children with acute lymphoblastic leukemia in second bone marrow relapse: a Children's Oncology Group Study (POG 8866).
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Polymorphisms in GRIA1 gene are a risk factor for asparaginase hypersensitivity during the treatment of childhood ALL.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Population pharmacokinetics of native Escherichia coli asparaginase.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Postinduction Dexamethasone and Individualized Dosing of Escherichia Coli L-Asparaginase Each Improve Outcome of Children and Adolescents With Newly Diagnosed Acute Lymphoblastic Leukemia: Results From a Randomized Study--Dana-Farber Cancer Institute ALL Consortium Protocol 00-01.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Preparation and nanoencapsulation of l-asparaginase II in chitosan-tripolyphosphate nanoparticles and in vitro release study.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Preserving catalytic activity and enhancing biochemical stability of the therapeutic enzyme asparaginase by biocompatible multilayered polyelectrolyte microcapsules.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Production of a novel N-terminal PEGylated crisantaspase.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Production of chemotherapeutic enzyme L-asparaginase from fungal source.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Profile of thrombin generation in children with acute lymphoblastic leukemia treated by Berlin-Frankfurt-Münster (BFM) protocols.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Promoter demethylation of the asparagine synthetase gene is required for ATF4-dependent adaptation to asparagine depletion.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Prophylactic therapy with enoxaparin during L-asparaginase treatment in children with acute lymphoblastic leukemia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Prophylactic therapy with enoxaparin in children with acute lymphoblastic leukemia and inherited thrombophilia during L-asparaginase treatment.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Prospective evaluation of the thrombotic risk in children with acute lymphoblastic leukemia carrying the MTHFR TT 677 genotype, the prothrombin G20210A variant, and further prothrombotic risk factors.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Proteins from Erwinia asparaginase Erwinase(®) and E. coli asparaginase 2 MEDAC(®) for treatment of human leukemia, show a multitude of modifications for which the consequences are completely unclear.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Protracted Administration of L-Asparaginase in Maintenance Phase Is the Risk Factor for Hyperglycemia in Older Patients with Pediatric Acute Lymphoblastic Leukemia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Purification and Characterization of Asparaginase from Phaseolus vulgaris Seeds.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Purification, Characterization and Comparison between Two New L-asparaginases from Bacillus PG03 and Bacillus PG04.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Purification, characterization and immunogenicity assessment of glutaminase free L-asparaginase from Streptomyces brollosae NEAE-115.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Purification, characterization, cytotoxicity and anticancer activities of L-asparaginase, anti-colon cancer protein, from the newly isolated alkaliphilic Streptomyces fradiae NEAE-82.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Quality-by-Design Approach for Biological API Encapsulation into Polymersomes Using "Off-the-Shelf" Materials: a Study on L-Asparaginase.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Recombinant L-Asparaginase from Zymomonas mobilis: A Potential New Antileukemic Agent Produced in Escherichia coli.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Reduced antithrombin III levels during L-asparaginase therapy.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Relative hyperglucagonemia in L-asparaginase-and prednisone-induced glucose intolerance in management of acute lymphocytic leukemia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Remission induction therapy for childhood acute lymphoblastic leukaemia: clinical and cellular pharmacology of vincristine, corticosteroids, L-asparaginase and anthracyclines.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Reversible MRI lesions due to pegaspargase treatment of non-Hodgkin's lymphoma.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Review of pharmacogenetics studies of L-asparaginase hypersensitivity in acute lymphoblastic leukemia points to variants in the GRIA1 gene.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Rhizobium etli asparaginase II: An alternative for acute lymphoblastic leukemia (ALL) treatment.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Role of glutamine depletion in directing tissue-specific nutrient stress responses to L-asparaginase.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Safety profile of asparaginase Erwinia chrysanthemi in a large compassionate-use trial.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Sagittal sinus thrombosis associated with transient free protein S deficiency after L-asparaginase treatment: case report and review of the literature.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Salvage therapy with single agent L-asparaginase followed by local irradiation in an elderly patient with CD56-positve primary isolated extramedullary T-cell lymphoblastic lymphoma of the sinus.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Selective deficiency in collagen-induced platelet aggregation during L-asparaginase therapy.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Sensitivity to L-asparaginase is not associated with expression levels of asparagine synthetase in t(12;21)+ pediatric ALL.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Sequelae of thrombotic or hemorrhagic complications following L-asparaginase therapy for childhood lymphoblastic leukemia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Sequencing and characterization of an L-asparaginase gene from a new species of Penicillium section Citrina isolated from Cerrado.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Sequential changes in platelet function and coagulation in leukemic children treated with L-asparaginase, prednisone, and vincristine.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Sequential therapy with daunorubicin and L-asparaginase in relapses of acute lymphoblastic leukemia in children.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Serial Ultrasound Monitoring for Early Recognition of Asparaginase Associated Pancreatitis in Children with Acute Lymphoblastic Leukemia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Serious neutropenia in ALL patients treated with L-asparaginase may be avoided by therapeutic monitoring of the enzyme activity in the circulation.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Severe hyperlipidemia in a case of acute lymphoblastic leukemia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Severe hyperlipidemia in a child with acute lymphoblastic leukemia treated with L-asparaginase and prednisone.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
SLC1A3 contributes to L-asparaginase resistance in solid tumors.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
SOHO State of the Art Updates and Next Questions: Management of Asparaginase Toxicity in Adolescents and Young Adults with Acute Lymphoblastic Leukemia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Staphylococcal endocarditis presenting with a renal infarct in a patient with acute lymphoblastic leukemia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Structural and biochemical properties of L-asparaginase.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Successful Management of a Child With Drug-induced Necrotizing Pancreatitis During Acute Lymphoblastic Leukemia Therapy: A Case Report.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Successful Management of l-Asparaginase-Associated Pancreatitis With Octreotide and Pegylated Asparaginase in 2 Patients With Acute Lymphoblastic Leukemia: Is There a Different Rare Warning Sign of Hypoglycemia for l-Asparaginase-Associated Pancreatitis?
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Successful management of severe L-asparaginase-associated pancreatitis by continuous regional arterial infusion of protease inhibitor and antibiotic.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Successful management with octreotide of a child with L-asparaginase induced hemorrhagic pancreatitis.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Successful treatment of acute lymphoblastic leukemia with L-asparaginase-induced intracranial hemorrhage to activated recombinant factor VIIa in a child.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Successful Treatment of Adolescents and Young Adults with Philadelphia-Negative Acute Lymphoblastic Leukemia by Novel L-Asparaginase-Intensified Induction Therapy and Cord Blood Transplantation: A Single-Center Decade Report.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Successful use of octreotide as a chemoprotectant for prevention of PEG-asparaginase-induced pancreatitis.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Superior sagittal sinus thrombosis in a patient with postdural puncture headache.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Surgical pancreatic complications induced by L-asparaginase.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Symptomatic Cerebral Sinovenous Thrombosis Associated With L-Asparaginase In Children With Acute Lymphoblastic Leukemia: A Single Institution Experience Over 17 Years.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Synthesis, characterization and immunogenicity of silk fibroin-L-asparaginase bioconjugates.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Targeted metabolomic analysis of amino acid response to L-asparaginase in adherent cells.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
TEL/AML1 gene fusion is related to in vitro drug sensitivity for L-asparaginase in childhood acute lymphoblastic leukemia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
The anti-asparagines antibodies correlate with L-asparagines activity and may affect clinical outcome of childhood acute lymphoblastic leukemia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
The Effect of Combination of Steroid and L-Asparaginase on Hyperglycemia in Children with Acute Lymphoblastic Leukemia (ALL).
Precursor Cell Lymphoblastic Leukemia-Lymphoma
The effect of hetastarch on the stability of L-asparaginase during freeze-thaw cycling.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
The effect of L-asparaginase of plasma coagulation factors in acute lymphoblastic leukemia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
The effect of L-asparaginase on antithrombin, plasminogen, and plasma coagulation during therapy for acute lymphoblastic leukemia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
The effect of L-asparaginase on DNA and RNA synthesis by lymphoblasts of acute lymphocytic leukemia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
The effect of Yarrowia lipolytical-asparaginase on apoptosis induction and inhibition of growth in Burkitt's lymphoma Raji and acute lymphoblastic leukemia MOLT-4 cells.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
The feasibility of Erwinia asparaginase for pediatric patients who developed an allergic reaction to E.coli asparaginase during treatment of acute lymphoblastic leukemia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
The glutaminase activity of L-asparaginase is not required for anticancer activity against ASNS-negative cells.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
The Incidence of Hypersensitivity Reactions to Pegylated Asparaginase in Children With Acute Lymphoblastic Leukemia: A City-wide Experience.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
The inhibition of lymphocyte blastogenesis by asparaginase: critical role of glutamine in both T and B lymphocyte transformation.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
The potential of halophilic and halotolerant bacteria for the production of antineoplastic enzymes: L-asparaginase and L-glutaminase.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
The prevalence and etiology of extreme hypertriglyceridemia in children: Data from a tertiary children's hospital.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
The risk of thrombosis in patients with acute leukemia: occurrence of thrombosis at diagnosis and during treatment.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Therapeutic Assessment of Targeting ASNS Combined with l-Asparaginase Treatment in Solid Tumors and Investigation of Resistance Mechanisms.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Therapeutic l-asparaginase: upstream, downstream and beyond.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Therapy of refractory adult acute lymphoblastic leukemia with vincristine and prednisone plus tandem methotrexate and L-asparaginase. Results of a Cancer and Leukemia Group B Study.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Thiol-maleimide poly(ethylene glycol) crosslinking of L-asparaginase subunits at recombinant cysteine residues introduced by mutagenesis.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Thromboembolism in adults with acute lymphoblastic leukemia during induction with L-asparaginase-containing multi-agent regimens: incidence, risk factors, and possible role of antithrombin.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Thromboembolism prophylaxis during L-asparaginase therapy in acute lymphoblastic leukemia - time to reconsider current approaches?
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Thromboembolism prophylaxis in adult patients with acute lymphoblastic leukemia treated in the GRAALL-2005 study.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Thrombosis associated with L-asparaginase therapy and low fibrinogen levels in adult acute lymphoblastic leukemia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Thrombosis related to the use of L-asparaginase in adults with acute lymphoblastic leukemia: a need to consider coagulation monitoring and clotting factor replacement.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Thrombotic complications during L-asparaginase treatment for acute lymphocytic leukemia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Thrombotic events are not exclusive to the remission induction period in patients with acute lymphoblastic leukemia: a report of two cases of cerebral sinus thrombosis.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Thrombotic Risk from Chemotherapy and Other Cancer Therapies.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Thyroid function during L-asparaginase therapy in children with acute lymphoblastic leukemia: difference between induction and late intensification.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Tolerability and efficacy of L-asparaginase therapy in pediatric patients with acute lymphoblastic leukemia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Toxic epidermal necrolysis following combination of methotrexate and trimethoprim-sulfamethoxazole.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Toxicity profile of repeated doses of PEG-asparaginase incorporated into a pediatric-type regimen for adult acute lymphoblastic leukemia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Transient hyperthyroidism following L-asparaginase therapy for acute lymphoblastic leukemia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Treatment of acute lymphoblastic leukemia in adults.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Treatment of children with advanced-stage lymphoblastic lymphoma with pegaspargase.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Treatment of human B-cell precursor leukemia in SCID mice by using a combination of the anti-CD19 immunotoxin B43-PAP with the standard chemotherapeutic drugs vincristine, methylprednisolone, and L-asparaginase.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Treatment of standard-risk acute lymphoblastic leukemia in children: the results of protocol AL841 from the Kyushu-Yamaguchi Children's Cancer Study Group in Japan.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Trend to efficacy and safety using antithrombin concentrate in prevention of thrombosis in children receiving l-asparaginase for acute lymphoblastic leukemia. Results of the PAARKA study.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Unexpected acute neurologic toxicity in the treatment of children with acute lymphoblastic leukemia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Unexpected mortality from the use of E. coli L-asparaginase during remission induction therapy for childhood acute lymphoblastic leukemia: a report from the Taiwan Pediatric Oncology Group.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Up-regulation of asparagine synthetase expression is not linked to the clinical response L-asparaginase in pediatric acute lymphoblastic leukemia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Update on the Use of l-Asparaginase in Infants and Adolescent Patients with Acute Lymphoblastic Leukemia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Use of L-asparaginase and cytosine arabinoside for refractory acute lymphocytic leukemia with particular reference to T-cell leukemia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Use of L-asparaginase in acute lymphoblastic leukemia: recommendations of the Polish Adult Leukemia Group.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Venous thromboembolism following L-asparaginase treatment for lymphoid malignancies in Korea.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Vincristine and prednisone vs vincristine, L-asparaginase, and prednisone for second remission induction of acute lymphocytic leukemia in children.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Vincristine but not imatinib could suppress mesenchymal niche's support to lymphoid leukemic cells.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Vincristine, prednisone and L-asparaginase in the induction of remission in children with acute lymphoblastic leukemia following relapse.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Weekly polyethylene glycol conjugated L-asparaginase compared with biweekly dosing produces superior induction remission rates in childhood relapsed acute lymphoblastic leukemia: a Pediatric Oncology Group Study.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Yarrowia lipolytica L-asparaginase inhibits the growth and migration of lung (A549) and breast (MCF7) cancer cells.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
[A case of acute lymphocytic leukemia complicated with multiple pancreatic pseudocysts probably caused by L-asparaginase]
Precursor Cell Lymphoblastic Leukemia-Lymphoma
[Acquired deficiencies in antithrombin III and C protein during treatment with L-asparaginase]
Precursor Cell Lymphoblastic Leukemia-Lymphoma
[Acquired hypofibrinogenemia in patients with leukemia during steroid therapy].
Precursor Cell Lymphoblastic Leukemia-Lymphoma
[Acute pancreatitis in children with acute lymphoblastic leukemia treated with L-asparaginase]
Precursor Cell Lymphoblastic Leukemia-Lymphoma
[Advances on the role of pegaspargase in the treatment of childhood leukemia].
Precursor Cell Lymphoblastic Leukemia-Lymphoma
[Attempt of treatment of acute lymphoblastic leukemia by L-asparaginase]
Precursor Cell Lymphoblastic Leukemia-Lymphoma
[Automated kinetic assay of plasmatic L-asparaginase activity undergoing therapy for acute lymphoblastic leukemia]
Precursor Cell Lymphoblastic Leukemia-Lymphoma
[Case of acute lymphoblastic leukemia with a striking response to L-asparaginase]
Precursor Cell Lymphoblastic Leukemia-Lymphoma
[Cerebral thrombosis in a child with acute lymphocytic leukemia during L-asparaginase therapy]
Precursor Cell Lymphoblastic Leukemia-Lymphoma
[Cerebral venous thrombosis as a complication of the treatment of acute T lymphoblastic leukemia with L-asparaginase]
Precursor Cell Lymphoblastic Leukemia-Lymphoma
[Clinical experiences with polyethylene glycol-bound E. coli L-asparaginase in patients with multiple recurrences of acute lymphoblastic leukemia]
Precursor Cell Lymphoblastic Leukemia-Lymphoma
[Comparative evaluation of the clinical effectiveness of 3 preparations of E. coli L-asparaginase]
Precursor Cell Lymphoblastic Leukemia-Lymphoma
[Comparison of polyethylene glycol conjugated asparaginase and L-asparaginase for treatment of childhood acute lymphoblastic leukemia]
Precursor Cell Lymphoblastic Leukemia-Lymphoma
[Complete remission obtained in refractory acute lymphocytic leukemia using high-dose cytosine arabinoside combined with low-dose L-asparaginase]
Precursor Cell Lymphoblastic Leukemia-Lymphoma
[Current national and international status of supportive therapy for the coagulopathy associated with L-asparaginase containing regimen for acute lymphoblastic leukemia].
Precursor Cell Lymphoblastic Leukemia-Lymphoma
[Desensitization therapy of acute lymphocytic leukemia with injection of L-asparaginase (Report of 5 cases)]
Precursor Cell Lymphoblastic Leukemia-Lymphoma
[Diabetic ketoacidosis and hypofibrinogenemia as a complication of the treatment with L-asparaginase of acute lymphoblastic leukemia]
Precursor Cell Lymphoblastic Leukemia-Lymphoma
[Effect of L-asparaginase on glucose metabolism in children with acute lymphoblastic leukemia]
Precursor Cell Lymphoblastic Leukemia-Lymphoma
[Further observations on the treatment of acute lymphocytic leukemia in children with L-asparaginase]
Precursor Cell Lymphoblastic Leukemia-Lymphoma
[Good response to ganciclovir in a patient of cytomegalovirus (CMV) interstitial pneumonitis and gastric ulcer following allogeneic bone marrow transplantation for acute lymphoblastic leukemia]
Precursor Cell Lymphoblastic Leukemia-Lymphoma
[Homonymous lateral hemianopsia revealing cerebral thrombophlebitis. Role of a deficiency of protein S induced by l-asparaginase]
Precursor Cell Lymphoblastic Leukemia-Lymphoma
[Hyperglycemia as a side effect of using L-asparaginase in children with acute lymphoblastic leukemia (ALL]
Precursor Cell Lymphoblastic Leukemia-Lymphoma
[Hypertriglyceridemia, Discorvered on a Pseudohyponatremia, Induced by L-asparaginase in the Treatment of B Acute Lymphoblastic Leukemia in Child].
Precursor Cell Lymphoblastic Leukemia-Lymphoma
[Hypertriglyceridemia, discovered on a pseudohyponatremia, induced by l-asparaginase in the treatment of B acute lymphoblastic leukemia in child].
Precursor Cell Lymphoblastic Leukemia-Lymphoma
[Iatrogenic hyperlipidemia after l-asparaginase and glucocorticoid treatment in two children with acute lymphoblastic leukemia]
Precursor Cell Lymphoblastic Leukemia-Lymphoma
[Intensification of induction therapy of acute lymphoblastic leukemia with L-asparaginase in children. Results of a 5-year randomised study (author's transl)]
Precursor Cell Lymphoblastic Leukemia-Lymphoma
[L-asparaginase in the therapy of acute lymphoblastic leukemia in children]
Precursor Cell Lymphoblastic Leukemia-Lymphoma
[L-asparaginase in the treatment of lymphoblastic leukemia in children]
Precursor Cell Lymphoblastic Leukemia-Lymphoma
[L-asparaginase, antithrombin III deficiency and thromboses (author's transl)]
Precursor Cell Lymphoblastic Leukemia-Lymphoma
[L-asparaginase-induced hyperlipidemia in a case of acute lymphoblastic leukemia]
Precursor Cell Lymphoblastic Leukemia-Lymphoma
[L-asparaginases of extremophilic microorganisms in biomedicine].
Precursor Cell Lymphoblastic Leukemia-Lymphoma
[Letter: Acute lymphoid leukemia: constant induction of remission by the combination of prednisone, vincristine and L-asparaginase (20 cases)]
Precursor Cell Lymphoblastic Leukemia-Lymphoma
[Lipidemic alterations in a child with acute lymphoblastic leukemia in treatment with L-aspariginase]
Precursor Cell Lymphoblastic Leukemia-Lymphoma
[New possibilities of treatment with PEG-L-asparaginase in patients with acute lymphoblastic leukemia sensitized to l-asparaginase E.coli and erwinase]
Precursor Cell Lymphoblastic Leukemia-Lymphoma
[Pancreatic pseudocyst. A case report and review of the literature]
Precursor Cell Lymphoblastic Leukemia-Lymphoma
[Preliminary observations on sequential therapy with daunorubicin and L-asparaginase in acute lymphoblastic leukemia]
Precursor Cell Lymphoblastic Leukemia-Lymphoma
[Preliminary results in the treatment of acute lymphoblastic leukemia in a child with L-asparaginase]
Precursor Cell Lymphoblastic Leukemia-Lymphoma
[Preliminary studies on the treatment of acute lymphocytic leukemia of the child with L-asparaginase]
Precursor Cell Lymphoblastic Leukemia-Lymphoma
[Preliminary study on the safety and pharmacodynamic action of low dose L-asparaginase]
Precursor Cell Lymphoblastic Leukemia-Lymphoma
[Recurrent thrombosed external hemorrhoids due to L-asparaginase administration in a Philadelphia chromosome-positive acute lymphoblastic leukemia patient].
Precursor Cell Lymphoblastic Leukemia-Lymphoma
[Repeated treatment with L-asparaginase of acute lymphoblastic leukemia in children]
Precursor Cell Lymphoblastic Leukemia-Lymphoma
[Research on the pharmacokinetics and pharmacodynamics of L-asparaginase during its treatment of childhood acute lymphoblastic leukemia]
Precursor Cell Lymphoblastic Leukemia-Lymphoma
[Results of repeated L-asparaginase treatment in acute lymphoblastic leukemia and lymphosarcoma in children]
Precursor Cell Lymphoblastic Leukemia-Lymphoma
[Results of treatment of children with acute lymphatic leukemia (ALL) according to the ALL V protocol of the Netherlands Working Group on Leukemia in Children]
Precursor Cell Lymphoblastic Leukemia-Lymphoma
[Safety of polyethylene glycol conjugated L-asparaginase in patients with acute lymphoblastic leukemia and T cell non-Hodgkin lymphoma].
Precursor Cell Lymphoblastic Leukemia-Lymphoma
[Serial EEG-examinations in children undergoing chemotherapy of ALL according to the Berlin-West-protocol (author's transl)]
Precursor Cell Lymphoblastic Leukemia-Lymphoma
[Side effects of L-asparaginase during therapies for remission induction and maintenance in children with acute lymphocytic leukemia]
Precursor Cell Lymphoblastic Leukemia-Lymphoma
[Significance of L-asparaginase activity and biochemical parameters evaluation in children with acute lymphoblastic leukemia]
Precursor Cell Lymphoblastic Leukemia-Lymphoma
[Successful readministration of L-asparaginase after development of severe hypertriglyceridemia in a young adult with T-cell acute lymphoblastic leukemia].
Precursor Cell Lymphoblastic Leukemia-Lymphoma
[Superior sagittal sinus thrombosis following L-asparaginase therapy of acute lymphoblastic leukemia]
Precursor Cell Lymphoblastic Leukemia-Lymphoma
[The efficacy of using prolonged-action L-asparaginase in a treatment program for acute lymphoblastic leukemia in adults]
Precursor Cell Lymphoblastic Leukemia-Lymphoma
[The role of anti L-asparaginase antibody in childhood acute lymphoblastic leukemia]
Precursor Cell Lymphoblastic Leukemia-Lymphoma
[The use of L-asparaginase in the treatment of acute lymphoblastic leukemia in childhood]
Precursor Cell Lymphoblastic Leukemia-Lymphoma
[Therapeutic alternatives to native L-asparaginase in the treatment of adult acute lymphoblastic leukemia]
Precursor Cell Lymphoblastic Leukemia-Lymphoma
[Transient diabetes following treatment of acute lymphoblastic leukemia with L-asparaginase]
Precursor Cell Lymphoblastic Leukemia-Lymphoma
[Transient diabetes mellitus related to L-asparaginase therapy]
Precursor Cell Lymphoblastic Leukemia-Lymphoma
[Transient diabetes mellitus with ketoacidosis in a child during the treatment of acute lymphoblastic leukemia with L-asparaginase]
Precursor Cell Lymphoblastic Leukemia-Lymphoma
[Treatment of acute lymphoblastic leukemia in children with L-asparaginase]
Precursor Cell Lymphoblastic Leukemia-Lymphoma
[Treatment with L-asparaginase of renal and testicular involvement in acute lymphoblastic leukemia in children (author's transl)]
Precursor Cell Lymphoblastic Leukemia-Lymphoma
[Update on L-asparaginase treatment in paediatrics.]
Precursor Cell Lymphoblastic Leukemia-Lymphoma
[Use of long-acting L-asparaginase (PEG-asparaginase) in acute lymphoblastic leukemia]
Precursor Cell Lymphoblastic Leukemia-Lymphoma
[Vindesine plus L-asparaginase and prednisolone therapy (VDS-VLP therapy) for remission induction in children with relapsed acute lymphoblastic leukemia]
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
A pre-clinical model of resistance to induction therapy in pediatric acute lymphoblastic leukemia.
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
AKR1C3 is a biomarker of sensitivity to PR-104 in preclinical models of T-cell acute lymphoblastic leukemia.
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
Association of allele-specific methylation of the ASNS gene with asparaginase sensitivity and prognosis in T-ALL.
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
Cellular drug resistance profiles that might explain the prognostic value of immunophenotype and age in childhood acute lymphoblastic leukemia.
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
Epigenetic Silencing Affects l-Asparaginase Sensitivity and Predicts Outcome in T-ALL.
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
Synergistic Cytotoxic Effect of L-Asparaginase Combined with Decitabine as a Demethylating Agent in Pediatric T-ALL, with Specific Epigenetic Signature.
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
Vincristine could partly suppress stromal support to T-ALL blasts during pegylated arginase I treatment.
Protein Deficiency
Cerebrovascular complications of L-asparaginase therapy in children with leukemia: aphasia and other neuropsychological deficits.
Protein S Deficiency
Sagittal sinus thrombosis associated with transient free protein S deficiency after L-asparaginase treatment: case report and review of the literature.
Protein S Deficiency
[Homonymous lateral hemianopsia revealing cerebral thrombophlebitis. Role of a deficiency of protein S induced by l-asparaginase]
Proteinuria
Biochemical criteria for the evaluation of drug efficiency on adjuvant arthritis and nephrotoxic serum nephritis in the rat: studies with phenylbutazone, L-Asparaginase, colchicine, lysine acetylsalicylate, and pyridinol carbamate.
Pulmonary Embolism
Fatal pulmonary embolism and antithrombin III deficiency in adult lymphoblastic leukaemia during L-asparaginase therapy.
Pulmonary Embolism
Hypersensitivity reactions to L-asparaginase do not impact on the remission duration of adults with acute lymphoblastic leukemia.
Quadriplegia
Coexistence of life threatening chemotherapy related leukoencephalopathy, saggital sinus thrombosis and multiple organ failure in a child with acute lymphoblastic leukemia: an unusual case with clinical recovery.
Sagittal Sinus Thrombosis
A rare complication in a child undergoing chemotherapy for acute lymphoblastic leukemia: Superior sagittal sinus thrombosis.
Sagittal Sinus Thrombosis
Endovascular mechanical thrombectomy for superior sagittal sinus thrombosis in a patient with T-lymphoblastic lymphoma treated with L-asparaginase.
Sagittal Sinus Thrombosis
Sagittal sinus thrombosis associated with transient free protein S deficiency after L-asparaginase treatment: case report and review of the literature.
Sagittal Sinus Thrombosis
[Superior sagittal sinus thrombosis during remission induction therapy for acute lymphoblastic leukemia]
Sagittal Sinus Thrombosis
[Superior sagittal sinus thrombosis following L-asparaginase therapy of acute lymphoblastic leukemia]
Salmonella Infections
Eugenol derivatives prospectively inhibit l-asparaginase: A heady target protein of Salmonella typhimurium.
Sarcoma
Inhibition of glutamine synthetase triggers apoptosis in asparaginase-resistant cells.
Sarcoma
Inhibition of Rd/3 rat sarcoma by L-asparaginase alone and in combination with sodium para-amino-salicylate.
Sarcoma
Inhibitory activity of L-asparaginase from Mycobacterium tuberculosis on Yoshida ascites sarcoma in rats.
Sarcoma
Studies on inhibition of viral oncogenesis. II. Inhibitory effect of L-asparaginase, clam liver extract and methotrexate on rous sarcoma virus focus formation.
Sarcoma
The inhibition of glutamine synthetase sensitizes human sarcoma cells to L-asparaginase.
Sarcoma
[Case of reticulum cell sarcoma treated with L-asparaginase and antibody to L-asparaginase]
Sarcoma
[The quantative measurement of cytocidal actions of antimetabolites, Vinca alcaloids and L-asparaginase against in vitro cultured Yoshida ascites sarcoma cells]
Sarcoma 180
Comparison of antitumor effect of recombinant L-asparaginase with wild type one in vitro and in vivo.
Sarcoma, Avian
Studies on inhibition of viral oncogenesis. II. Inhibitory effect of L-asparaginase, clam liver extract and methotrexate on rous sarcoma virus focus formation.
Sarcoma, Myeloid
Acute myeloid leukemia with mediastinal myeloid sarcoma refractory to acute myeloid leukemia therapy but responsive to L-asparaginase.
Seizures
A rare complication in a child undergoing chemotherapy for acute lymphoblastic leukemia: Superior sagittal sinus thrombosis.
Seizures
Cerebrovascular complications of L-asparaginase in the therapy of acute lymphoblastic leukemia.
Seizures
Epileptic seizures after octreotide administration in a 6.5-year-old female with ALL and L-asparaginase associated pancreatitis: a possible drug interaction.
Seizures
Intracranial hemorrhage and focal seizures secondary to use of L-asparaginase during induction therapy of acute lymphocytic leukemia.
Seizures
L-asparaginase-induced posterior reversible encephalopathy syndrome during acute lymphoblastic leukemia treatment in children.
Seizures
L-asparaginase-induced reversible posterior leukoencephalopathy syndrome in a child with acute lymphoblastic leukemia.
Seizures
L-asparaginase-provoked seizures as singular expression of central nervous toxicity.
Seizures
Polyethylene glycol-L-asparaginase versus native L-asparaginase in canine non-Hodgkin's lymphoma.
Seizures
Sagittal sinus thrombosis associated with transient free protein S deficiency after L-asparaginase treatment: case report and review of the literature.
Seizures
[Neurologic complications during chemotherapy of children with acute lymphoid leukemia]
Sinus Thrombosis, Intracranial
MR diagnosis of dural venous sinus thrombosis complicating L-asparaginase therapy.
Sinus Thrombosis, Intracranial
Ocular complications of sigmoid sinus thrombosis from L-asparaginase.
Spasms, Infantile
[Analysis of hypofibrinogenemias found on routine coagulation screening tests and identification of heterozygous dysfibrinogenemia or fibrinogen deficiency]
Spinal Cord Diseases
Acute and sub-acute neurological toxicity in children treated for acute lymphoblastic leukemia.
Starvation
A genome-wide view of the in vitro response to l-asparaginase in acute lymphoblastic leukemia.
Starvation
Effect of l-asparaginase and asparagine deprivation on RNA metabolism in mouse leukemia L 5178Y cells in suspension culture.
Starvation
EVI1 triggers metabolic reprogramming associated with leukemogenesis and increases sensitivity to L-asparaginase.
Starvation
Heterodimers of the Arabidopsis Transcription Factors bZIP1 and bZIP53 Reprogram Amino Acid Metabolism during Low Energy Stress.
Starvation
Isolation and screening of extracellular anticancer enzymes from halophilic and halotolerant bacteria from different saline environments in Iran.
Starvation
Myeloma Cells Deplete Bone Marrow Glutamine and Inhibit Osteoblast Differentiation Limiting Asparagine Availability.
Starvation
Production, purification, characterization, antioxidant and antiproliferative activities of extracellular L-asparaginase produced by Fusarium equiseti AHMF4.
Starvation
Synthetic lethality of glutaminolysis inhibition, autophagy inactivation and asparagine depletion in colon cancer.
Starvation
The eIF2 kinase GCN2 is essential for the murine immune system to adapt to amino acid deprivation by asparaginase.
Status Epilepticus
A rare complication in a child undergoing chemotherapy for acute lymphoblastic leukemia: Superior sagittal sinus thrombosis.
Stomatitis
Chemoimmunotherapy for metastatic breast cancer with 5-fluorouracil, adriamycin, cyclophosphamide, methotrexate, L-asparaginase, Corynebacterium parvum, and Pseudomonas vaccine.
Stomatitis
Methotrexate plus L-asparaginase. An active combination for children with acute nonlymphocytic leukemia.
Stroke
99Tcm-HMPAO SPECT and magnetic resonance studies in L-asparaginase induced cerebrovascular accident.
Stroke
L-asparaginase therapy with concomitant cranial venous thrombosis: can MRI help avoiding stroke.
Stroke
[Stroke after treatment with L-asparaginase: correlation between clinical improvement, neuroimaging findings, and levels of coagulation factors]
Tetany
Alterations of immunoreactive somatostatin in thyroid C cells after induced hypercalcemia, hypocalcemia, and antithyroid drug treatment.
Thromboembolism
Disordered hemostasis associated with severely depressed fibrinolysis demonstrated using a simultaneous thrombin and plasmin generation assay during L-asparaginase induction therapy in pediatric acute lymphoblastic leukemia.
Thromboembolism
L-asparaginase induced fatal cortical venous thrombosis in acute lymphoblastic leukemia.
Thromboembolism
Prophylactic therapy with enoxaparin during L-asparaginase treatment in children with acute lymphoblastic leukemia.
Thromboembolism
Prospective evaluation of the thrombotic risk in children with acute lymphoblastic leukemia carrying the MTHFR TT 677 genotype, the prothrombin G20210A variant, and further prothrombotic risk factors.
Thromboembolism
The risk of thrombosis in patients with acute leukemia: occurrence of thrombosis at diagnosis and during treatment.
Thromboembolism
Thromboembolism in adults with acute lymphoblastic leukemia during induction with L-asparaginase-containing multi-agent regimens: incidence, risk factors, and possible role of antithrombin.
Thromboembolism
Thromboembolism prophylaxis during L-asparaginase therapy in acute lymphoblastic leukemia - time to reconsider current approaches?
Thrombophilia
Changes in hypercoagulability by asparaginase: a randomized study between two asparaginases.
Thrombophilia
Evidence of a hypercoagulable state in patients with acute lymphoblastic leukemia treated with low dose of E. coli L-asparaginase: a GIMEMA study.
Thrombophilia
Hypercoagulability during L-asparaginase treatment: the effect of antithrombin III supplementation in vivo.
Thrombophilia
Increased thrombin generation during fibrinogen and platelet recovery as an explanation for hypercoagulability in children with L-asparaginase therapy for ALL or NHL: a preliminary report.
Thrombophilia
Prophylactic therapy with enoxaparin in children with acute lymphoblastic leukemia and inherited thrombophilia during L-asparaginase treatment.
Thrombophilia
Thrombosis in childhood acute lymphoblastic leukaemia: epidemiology, aetiology, diagnosis, prevention and treatment.
Thrombophilia
[Superior sagittal sinus thrombosis after intrathecal chemotherapy and intravenous high-dose cytarabine in an acute myeloid leukemia case with t(8;21)(q22;q22)].
Thrombophlebitis
[Homonymous lateral hemianopsia revealing cerebral thrombophlebitis. Role of a deficiency of protein S induced by l-asparaginase]
Thrombosis
A syndrome of thrombosis and hemorrhage complicating L-asparaginase therapy for childhood acute lymphoblastic leukemia.
Thrombosis
Acute and sub-acute neurological toxicity in children treated for acute lymphoblastic leukemia.
Thrombosis
Adverse effects on hemostatic function of drugs used in hematologic malignancies.
Thrombosis
Cerebrospinal fluid proteomics in children during induction for acute lymphoblastic leukemia: A pilot study.
Thrombosis
Changes in hemostatic and fibrinolytic proteins in patients receiving L-asparaginase therapy.
Thrombosis
Cryoprecipitate-induced mesenteric venous thrombosis during L-asparaginase therapy for acute lymphoblastic leukaemia.
Thrombosis
Effect of L-asparaginase administration on coagulation and platelet function in children with leukemia.
Thrombosis
Effect of L-asparaginase therapy for acute lymphoblastic leukemia on plasma vitamin K-dependent coagulation factors and inhibitors.
Thrombosis
Factors with conformational effects on haemostatic serpins: implications in thrombosis.
Thrombosis
Inhibition of hypercoagulation by antithrombin substitution in E. coli L-asparaginase-treated children.
Thrombosis
L-asparaginase therapy with concomitant cranial venous thrombosis: can MRI help avoiding stroke.
Thrombosis
L-asparaginase-induced antithrombin type I deficiency: implications for conformational diseases.
Thrombosis
Prophylactic therapy with enoxaparin during L-asparaginase treatment in children with acute lymphoblastic leukemia.
Thrombosis
Sequelae of thrombotic or hemorrhagic complications following L-asparaginase therapy for childhood lymphoblastic leukemia.
Thrombosis
Symptomatic Cerebral Sinovenous Thrombosis Associated With L-Asparaginase In Children With Acute Lymphoblastic Leukemia: A Single Institution Experience Over 17 Years.
Thrombosis
The effect of L-asparaginase on antithrombin, plasminogen, and plasma coagulation during therapy for acute lymphoblastic leukemia.
Thrombosis
The risk of thrombosis in patients with acute leukemia: occurrence of thrombosis at diagnosis and during treatment.
Thrombosis
Thromboembolism prophylaxis in adult patients with acute lymphoblastic leukemia treated in the GRAALL-2005 study.
Thrombosis
Thrombosis associated with L-asparaginase therapy and low fibrinogen levels in adult acute lymphoblastic leukemia.
Thrombosis
Thrombosis related to the use of L-asparaginase in adults with acute lymphoblastic leukemia: a need to consider coagulation monitoring and clotting factor replacement.
Thrombosis
Thrombotic complications during L-asparaginase treatment for acute lymphocytic leukemia.
Thrombosis
Trend to efficacy and safety using antithrombin concentrate in prevention of thrombosis in children receiving l-asparaginase for acute lymphoblastic leukemia. Results of the PAARKA study.
Thrombosis
Unbalanced coagulation-fibrinolysis potential during L-asparaginase therapy in children with acute lymphoblastic leukaemia.
Thrombosis
Use of L-asparaginase in acute lymphoblastic leukemia: recommendations of the Polish Adult Leukemia Group.
Thrombosis
Whole-exome sequencing identified genetic risk factors for asparaginase-related complications in childhood ALL patients.
Thrombosis
[Cerebral sinovenous thrombosis and acquired antithrombin, protein C and S deficiency during chemotherapy in a young man: report of a case]
Thyroid Nodule
Transient hyperthyroidism following L-asparaginase therapy for acute lymphoblastic leukemia.
Tuberculosis
Distinct functional properties of secretory l-asparaginase Rv1538c involved in phagosomal survival of Mycobacterium tuberculosis.
Tuberculosis
Identification and validation of l-asparaginase as a potential metabolic target against Mycobacterium tuberculosis.
Tuberculosis
Inhibitory activity of L-asparaginase from Mycobacterium tuberculosis on Yoshida ascites sarcoma in rats.
Tuberculosis
Rewiring of Metabolic Network in Mycobacterium tuberculosis During Adaptation to Different Stresses.
Tumor Lysis Syndrome
Childhood non-Hodgkin's lymphoma--results of treatment with ALL high-risk protocol.
Ureteral Obstruction
Ureteral obstruction caused by L-asparaginase-induced pancreatitis in a child with acute lymphoblastic leukemia.
Urticaria
An experience with plasma exhcange treatment of acute lymphoblastic leukemia in a case with fulminant hepatitis related to l-asparaginase.
Vaccinia
[Hypoparathyroidismus following L-asparaginase and vaccinia virus infection. Effect of hypocalcemia on phagocytosis and the function of lymphocytes]
Vaccinia
[Immunity after producing vaccinia generalisata during treatment with L-asparaginase in rabbits (author's transl)]
Venereal Tumors, Veterinary
Conventional-Vincristine Sulfate vs. Modified Protocol of Vincristine Sulfate and L-Asparaginase in Canine Transmissible Venereal Tumor.
Venous Thromboembolism
L-asparaginase and venous thromboembolism in acute lymphocytic leukemia.
Venous Thromboembolism
Venous thromboembolism following L-asparaginase treatment for lymphoid malignancies in Korea.
Venous Thrombosis
Cerebral venous thrombosis in adult patients with acute lymphoblastic leukemia or lymphoblastic lymphoma during induction chemotherapy with l-asparaginase: The GRAALL experience.
Venous Thrombosis
Hypersensitivity reactions to L-asparaginase do not impact on the remission duration of adults with acute lymphoblastic leukemia.
Venous Thrombosis
L-asparaginase induced fatal cortical venous thrombosis in acute lymphoblastic leukemia.
Venous Thrombosis
L-asparaginase therapy with concomitant cranial venous thrombosis: can MRI help avoiding stroke.
Venous Thrombosis
Multiple Severe Toxicities of L-Asparaginase and Their Innovative Management during Induction Therapy of Acute Lymphoblastic Leukemia in an Adult Patient.
Venous Thrombosis
Profile of thrombin generation in children with acute lymphoblastic leukemia treated by Berlin-Frankfurt-Münster (BFM) protocols.
Venous Thrombosis
Prophylactic therapy with enoxaparin during L-asparaginase treatment in children with acute lymphoblastic leukemia.
Venous Thrombosis
Superior sagittal sinus thrombosis in a patient with postdural puncture headache.
Venous Thrombosis
Venous thrombosis as a complication of L-asparaginase treatment in a child.
Venous Thrombosis
[Cerebral venous thrombosis as a complication of the treatment of acute T lymphoblastic leukemia with L-asparaginase]
Venous Thrombosis
[MRI abnormalities of the brain in neurologic complications following treatment of cancer in children]
Virus Diseases
[Hypoparathyroidismus following L-asparaginase and vaccinia virus infection. Effect of hypocalcemia on phagocytosis and the function of lymphocytes]
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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
0.38
aspartic acid
-
pH 8, reaction with glutamine, C-terminally tagged recombinant enzyme
1.3
L-aspartic acid
-
pH 8, reaction with NH3, C-terminally tagged recombinant enzyme
0.08
ATP
-
pH 8, reaction with glutamine, C-terminally tagged recombinant enzyme
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TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
1.3
L-aspartic acid
-
pH 8, reaction with glutamine, C-terminally tagged recombinant enzyme
1.7
L-aspartic acid
-
pH 8, reaction with NH3, C-terminally tagged recombinant enzyme
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Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
SOURCE
-
high expression in T-lineage and low expression in B-lineage
brenda
-
higher expression than in lymphoblastic leukemia cells
brenda
additional information
additional information
analysis of mRNA expression in 19 ovarian cancer cell lines
brenda
additional information
-
analysis of mRNA expression in 19 ovarian cancer cell lines
brenda
additional information
-
the enzyme is ubiquitous in its organ distribution in mammals, but basal expression is relatively low in tissues other than the exocrine pancreas
brenda
additional information
-
ASNS expression is not detected in normal brain tissue, and the expression is marginal in low-grade pilocytic astrocytoma and diffuse astrocytoma
brenda
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LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY
GeneOntology No.
LITERATURE
SOURCE
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GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
malfunction
asparagine synthetase deficiency, ASD, is a neurological disorder having severe impacts on psychomotor development and mortality at an early age. Children with mutations in the ASNS gene exhibit developmental delays, intellectual disability, microcephaly, intractable seizures, and progressive brain atrophy. Mutations in the ASNS gene have been clinically associated with asparagine synthetase deficiency (ASD), phenotype. Neurologic disorder associated with asparagine synthetase deficiency (ASD). The transcription factor ATF4 binds to an enhancer element within the proximal promoter of the ASNS gene and activates transcription. Role of ATF4 in tumor cell survival and proliferation, ATF4 knockdown causes reduced survival in HT-1080 fibrosarcoma and DLD-1 colorectal adenocarcinoma cells in the absence of nonessential amino acids. Reduced proliferative capacity and increased apoptosis correlate with lower ASNS expression in the ATF4-deficient cells. Supplementation of the tumor cells with asparagine, but not other amino acids, leads to increased cell survival. Role of ASNS activity in modulating tumor growth
physiological function
asparagine synthetase (ASNS) catalyzes the synthesis of asparagine and glutamate from aspartate and glutamine in an ATP-dependent amidotransferase reaction. Elevated ASNS protein expression is associated with resistance to asparaginase therapy in childhood acute lymphoblastic leukemia. Regulation of ASNS expression, overview. transcription factor ATF4 binds to an enhancer element within the proximal promoter of the ASNS gene and activates transcription. Asparagine depletion activates the amino acid response, AAR, whereas endoplasmic reticulum stress activates the unfolded protein response, UPR
malfunction
-
knockdown of asparagine synthetase (ASNS) leads to cell death even in the presence of glutamine, which can be reversed by addition of exogenous asparagine. Asparagine plays a critical role in regulating cellular adaptation to glutamine depletion. ASNS knockdown leads to profound apoptosis even in the presence of glutamine. Addition of extracellular asparagine completely restored cell survival and proliferation. Clinically, the expression of ASNS correlates with the progression of disease and poor prognosis of glioma and neuroblastoma patients. In neuroblastoma with unfavourable prognosis, ASNS expression is significantly higher. Asparagine-induced suppression of apoptosis: asparagine addition to glutamine-deprived cells alters the transcriptional response, suppressing the induction of the reported UPR effectors CHOP and XBP1 while maintaining the transcriptional induction of adaptive components of the UPR-response such as ASNS and HERPUD1. At the protein level, exogenous addition of asparagine suppresses CHOP induction without altering ATF4 accumulation or upstream eIF2alpha phosphorylation
physiological function
additional information
physiological function
-
elevated expression of ASNS protein is associated with resistance to asparaginase therapy in childhood acute lymphoblastic leukemia and may be a predictive factor in drug sensitivity for certain solid tumors as well. Activation of the GCN2-eIF2-ATF4 signaling pathway, leading to increased ASNS expression, appears to be a component of solid tumor adaptation to nutrient deprivation and/or hypoxia, roles of the enzyme in fetal development, tissue differentiation, and tumor growth, overview. Possible correlation between ASNase sensitivity and the DNA methylation status of the ASNS gene
physiological function
-
asparagine synthetase (ASNS) plays an important role during tumor cell accumulation and progression by maintaining cell viability. The enzyme synthesizes asparagine de novo from aspartate and glutamine. Asparagine plays a critical role in regulating cellular adaptation to glutamine depletion. The anti-apoptotic function of glutamine depends on the ability of asparagine synthetase to maintain glutamine-dependent biosynthesis of asparagine. Transcription factor ATF4 induces asparagine synthetase which results in glutamine-dependent asparagine synthesis from aspartate, in turn asparagine accumulation then suppresses GCN2 and reduces ATF4
additional information
glutamine is predicted to bind in a manner so that the carboxamide group is oriented toward the interface of the two domains to allow the transfer of an ammonia group from glutamine to aspartate
additional information
-
human enzyme activity is highly regulated in response to cell stress, primarily by increased transcription from a single gene located on chromosome 7, ASNS transcription control by C/EBP-ATF response element within the promoter. Protein limitation or an imbalanced dietary amino acid composition activate the ASNS gene through the amino acid response, a process that is replicated in cell culture through limitation for any single essential amino acid
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UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable).
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable). ASNS_HUMAN
561
0
64370
Swiss-Prot
other Location (Reliability: 5)
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PDB
SCOP
CATH
UNIPROT
ORGANISM
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MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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SUBUNIT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
additional information
the enzyme contains two functional domains, the N-terminal domain (residues 1-208) consists of a two-layer, antiparallel beta-sheet core surrounded by four alpha-helices, this domain harbors the glutamine-binding pocket, consisting of residues Arg49, Asn75, Glu77, and Asp97. The C-terminal domain (residues 209-561) is composed primarily of alpha-helices, but also encompasses a five-stranded, parallel beta-sheet that contains the ATP-binding site: residues Leu256, Val288, Asp295, Ser363, Gly364, Glu365, and Asp401
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PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
A380S
naturally occuring mutation, homozygous mutation, mutation of a polar residue in the hydrophobic region
A6E
naturally occuring mutation, compound heterozygous, mutation of a charged amino acid in hydrophobic region, causing steric clash with Phe8
F362V
naturally occuring mutation, homozygous mutation, causes a decrease in van der Waals interactions
G289A
naturally occuring mutation, compound heterozygous, mutation proximal to the ATP-binding site, causing steric hindrance with Ser293
L145S
naturally occuring mutation, compound heterozygous, mutation of a polar side chain in hydrophobic region
L247W
naturally occuring mutation, causes a decrease in van der Waals interactions
R340H
naturally occuring mutation, homozygous mutation, causes a loss of hydrogen bonds, and a steric clash with Phe482
R49Q
naturally occuring mutation, homozygous mutation of the glutamine-binding site, causes loss of hydrogen bonding
R550C
S480F
naturally occuring mutation, compound heterozygous, mutation of a nonpolar residue on protein surface that may decrease solubility
T337I
naturally occuring mutation, Proximal to ATP-binding site, causes a hydrophobic patch on protein that may decrease solubility
V489D
naturally occuring mutation, compound heterozygous, inserts a charged amino acid in hydrophobic region
Y398C
naturally occuring mutation, homozygous mutation, causes a decrease in van der Waals interactions, solvent-accessible thiol group
C1A
-
altering Cys-1 to either Ala or Ser eliminated the Gln-dependent activity, while only minimally affecting the kinetic properties of the NH4+-dependent reaction
C1S
-
altering Cys-1 to either Ala or Ser eliminated the Gln-dependent activity, while only minimally affecting the kinetic properties of the NH4+-dependent reaction
additional information
R550C
naturally occuring mutation, causes a decrease in side chain length likely to result in loss of interactions
R550C
naturally occuring mutation, homozygous mutation, causes a decrease in side chain length likely to result in loss of interactions
additional information
identification of two naturally occuring nonsense mutations, R407* and W541Cfs*5 (frameshift mutation), leading to truncated enzyme mutants
additional information
-
the replacement of the N-terminal Cys by Ala results in the loss of the Gln-dependent Asn synthetase activity, while the NH4+-dependent activity remains unaffected
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GENERAL STABILITY
ORGANISM
UNIPROT
LITERATURE
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STORAGE STABILITY
ORGANISM
UNIPROT
LITERATURE
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PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
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CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
C-terminally tagged enzyme, baculovirus-based expression system, the recombinant enzyme is correctly processed, exhibits high activity and is stable on prolonged storage at -80°C
-
cloned into a 2 mü plasmid, pBS24.1GAS, suitable for replication in a Saccharomyces cerevisiae ciro strain AB116
-
mutant enzyme in which the N-terminal Cys is replaced by Ala is expressed in Saccharomyces
-
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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
ASNS activity is highly responsive to cellular stress, primarily by increased transcription from the single gene located on chromosome 7. The transcription factor ATF4 binds to an enhancer element within the proximal promoter of the ASNS gene and activates transcription
human enzyme activity is highly regulated in response to cell stress, primarily by increased transcription from a single gene located on chromosome 7. Protein limitation or an imbalanced dietary amino acid composition activate the ASNS gene through the amino acid response, a process that is replicated in cell culture through limitation for any single essential amino acid. Endoplasmic reticulum stress also increases ASNS transcription through the PERK-eIF2-ATF4 arm of the unfolded protein response. Both the amino acid response and unfolded protein response lead to increased synthesis of ATF4, which binds to the C/EBP-ATF response element and induces ASNS transcription
-
transcription factor ATF4 induces asparagine synthetase which results in glutamine-dependent asparagine synthesis from aspartate, in turn asparagine accumulation then suppresses GCN2 and reduces ATF4
-
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APPLICATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
analysis
mass spectrometry-based procedure for the direct quantification of asparagine synthetase protein concentration in complex sample mixtures. Assay is able to distinguish samples from transformed cell lines that express the enzyme over a wide dynamic range of concentration. The method directly detects asparagine synthetase protein, use in blast samples from patients with acute lymphoblastic leukemia
medicine
medicine
analysis of asparagine synthetase mRNA expression in 19 ovarian cancer cell lines. L-Asparaginase activity is only weakly correlated with asparagine synthetase mRNA expression, while asparagine synthetase protein expression measured by liquid-phase immunoassay exhibits a much stronger correlation
medicine
mass spectrometry-based procedure for the direct quantification of asparagine synthetase protein concentration in complex sample mixtures. Assay is able to distinguish samples from transformed cell lines that express the enzyme over a wide dynamic range of concentration. The method directly detects asparagine synthetase protein, use in blast samples from patients with acute lymphoblastic leukemia
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Sheng, S.; Moraga, D.A.; van Heeke, G.; Schuster, S.M.
High-level expression of human asparagine synthetase and production of monoclonal antibodies for enzyme purification
Protein Expr. Purif.
3
337-346
1992
Homo sapiens
brenda
Van Heeke, G.; Schuster, S.M.
The N-terminal cysteine of human asparagine synthetase is essential for glutamine-dependent activity
J. Biol. Chem.
264
19475-19477
1989
Homo sapiens
brenda
Sheng, S.; Moraga-Amador, D.A.; van Heeke, G.; Allison, R.D.; Richards, N.G.J.; Schuster, S.M.
Glutamine inhibits the ammonia-dependent activities of two Cys-1 mutants of human asparagine synthetase through the formation of an abortive complex
J. Biol. Chem.
268
16771-16780
1993
Homo sapiens
brenda
Campaigne Larsen, M.; Schuster, S.M.
The topology of the glutamine and ATP binding sites of human asparagine synthetase
Arch. Biochem. Biophys.
299
15-22
1992
Homo sapiens
brenda
Milman, H.A.; Cooney, D.A.
The distribution of L-asparagine synthetase in the principal organs of several mammalian and avian species
Biochem. J.
142
27-35
1974
Bos taurus, Canis lupus familiaris, Cavia porcellus, Gallus gallus, Oryctolagus cuniculus, Felis catus, Ovis aries, Homo sapiens, Lupinus albus, Meleagris gallopavo, Platyrrhini, Mus musculus, Sus scrofa
brenda
Aslanian, A.M.; Fletcher, B.S.; Kilberg, M.S.
Asparagine synthetase expression alone is sufficient to induce l-asparaginase resistance in MOLT-4 human leukaemia cells
Biochem. J.
357
321-328
2001
Homo sapiens
brenda
Dubbers, A.; Wurthwein, G.; Muller, H.J.; Schulze-Westhoff, P.; Winkelhorst, M.; Kurzknabe, E.; Lanvers, C.; Pieters, R.; Kaspers, G.J.L.; Creutzic, U.; Ritter, J.; Boos, J.
Asparagine synthetase activity in paediatric acute leukaemias: AML-M5 subtype shows lowest activity
Br. J. Haematol.
109
427-429
2000
Homo sapiens
brenda
Ciustea, M.; Gutierrez, J.A.; Abbatiello, S.E.; Eyler, J.R.; Richards, N.G.
Efficient expression, purification, and characterization of C-terminally tagged, recombinant human asparagine synthetase
Arch. Biochem. Biophys.
440
18-27
2005
Homo sapiens
brenda
Al Sarraj, J.; Vinson, C.; Thiel, G.
Regulation of asparagine synthetase gene transcription by the basic region leucine zipper transcription factors ATF5 and CHOP
Biol. Chem.
386
873-879
2005
Homo sapiens
brenda
Stams, W.A.; den Boer, M.L.; Holleman, A.; Appel, I.M.; Beverloo, H.B.; van Wering, E.R.; Janka-Schaub, G.E.; Evans, W.E.; Pieters, R.
Asparagine synthetase expression is linked with L-asparaginase resistance in TEL-AML1-negative but not TEL-AML1-positive pediatric acute lymphoblastic leukemia
Blood
105
4223-4225
2005
Homo sapiens
brenda
Krejci, O.; Starkova, J.; Otova, B.; Madzo, J.; Kalinova, M.; Hrusak, O.; Trka, J.
Upregulation of asparagine synthetase fails to avert cell cycle arrest induced by L-asparaginase in TEL/AML1-positive leukaemic cells
Leukemia
18
434-441
2004
Homo sapiens
brenda
Richards, N.G.; Kilberg, M.S.
Asparagine synthetase chemotherapy
Annu. Rev. Biochem.
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2006
Escherichia coli, Homo sapiens
brenda
Leslie, M.; Case, M.C.; Hall, A.G.; Coulthard, S.A.
Expression levels of asparagine synthetase in blasts from children and adults with acute lymphoblastic leukaemia
Br. J. Haematol.
132
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2006
Homo sapiens
brenda
Cui, H.; Darmanin, S.; Natsuisaka, M.; Kondo, T.; Asaka, M.; Shindoh, M.; Higashino, F.; Hamuro, J.; Okada, F.; Kobayashi, M.; Nakagawa, K.; Koide, H.; Kobayashi, M.
Enhanced expression of asparagine synthetase under glucose-deprived conditions protects pancreatic cancer cells from apoptosis induced by glucose deprivation and cisplatin
Cancer Res.
67
3345-3355
2007
Homo sapiens (P08243)
brenda
Iwamoto, S.; Mihara, K.; Downing, J.R.; Pui, C.H.; Campana, D.
Mesenchymal cells regulate the response of acute lymphoblastic leukemia cells to asparaginase
J. Clin. Invest.
117
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2007
Homo sapiens
brenda
Chen, H.; Kilberg, M.S.
Alignment of the transcription start site coincides with increased transcriptional activity from the human asparagine synthetase gene following amino acid deprivation of HepG2 cells
J. Nutr.
136
2463-2467
2006
Homo sapiens
brenda
Fujita, Y.; Ito, M.; Nozawa, Y.; Yoneda, M.; Oshida, Y.; Tanaka, M.
CHOP (C/EBP homologous protein) and ASNS (asparagine synthetase) induction in cybrid cells harboring MELAS and NARP mitochondrial DNA mutations
Mitochondrion
7
80-88
2007
Homo sapiens
brenda
Lorenzi, P.L.; Reinhold, W.C.; Rudelius, M.; Gunsior, M.; Shankavaram, U.; Bussey, K.J.; Scherf, U.; Eichler, G.S.; Martin, S.E.; Chin, K.; Gray, J.W.; Kohn, E.C.; Horak, I.D.; Von Hoff, D.D.; Raffeld, M.; Goldsmith, P.K.; Caplen, N.J.; Weinstein, J.N.
Asparagine synthetase as a causal, predictive biomarker for L-asparaginase activity in ovarian cancer cells
Mol. Cancer Ther.
5
2613-2623
2006
Homo sapiens
brenda
Su, N.; Pan, Y.X.; Zhou, M.; Harvey, R.C.; Hunger, S.P.; Kilberg, M.S.
Correlation between asparaginase sensitivity and asparagine synthetase protein content, but not mRNA, in acute lymphoblastic leukemia cell lines
Pediatr. Blood Cancer
50
274-279
2008
Homo sapiens
brenda
Abbatiello, S.E.; Pan, Y.X.; Zhou, M.; Wayne, A.S.; Veenstra, T.D.; Hunger, S.P.; Kilberg, M.S.; Eyler, J.R.; Richards, N.G.; Conrads, T.P.
Mass spectrometric quantification of asparagine synthetase in circulating leukemia cells from acute lymphoblastic leukemia patients
J. Proteomics
71
61-70
2008
Homo sapiens (P08243)
brenda
Lorenzi, P.L.; Llamas, J.; Gunsior, M.; Ozbun, L.; Reinhold, W.C.; Varma, S.; Ji, H.; Kim, H.; Hutchinson, A.A.; Kohn, E.C.; Goldsmith, P.K.; Birrer, M.J.; Weinstein, J.N.
Asparagine synthetase is a predictive biomarker of L-asparaginase activity in ovarian cancer cell lines
Mol. Cancer Ther.
7
3123-3128
2008
Homo sapiens (P08243), Homo sapiens
brenda
Balasubramanian, M.N.; Butterworth, E.A.; Kilberg, M.S.
Asparagine synthetase: regulation by cell stress and involvement in tumor biology
Am. J. Physiol. Endocrinol. Metab.
304
E789-E799
2013
Homo sapiens
brenda
Lomelino, C.L.; Andring, J.T.; McKenna, R.; Kilberg, M.S.
Asparagine synthetase function, structure, and role in disease
J. Biol. Chem.
292
19952-19958
2017
Homo sapiens (P08243), Escherichia coli (P22106)
brenda
Zhang, J.; Fan, J.; Venneti, S.; Cross, J.R.; Takagi, T.; Bhinder, B.; Djaballah, H.; Kanai, M.; Cheng, E.H.; Judkins, A.R.; Pawel, B.; Baggs, J.; Cherry, S.; Rabinowitz, J.D.; Thompson, C.B.
Asparagine plays a critical role in regulating cellular adaptation to glutamine depletion
Mol. Cell
56
205-218
2014
Homo sapiens
brenda
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