Reference on EC 6.3.4.5 - argininosuccinate synthase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Shargool, P.D.
Purification of argininosuccinate synthetase from cotyledons of germinating peas
Phytochemistry
10
2029-2032
1971
Pisum sativum
-
Ratner, S.
Enzymes of arginine and urea synthesis
Adv. Enzymol. Relat. Areas Mol. Biol.
39
1-90
1973
Bos taurus
Saheki, T.; Kusumi, T.; Takada, S.; Katsunuma, T.; Katunuma, N.
Crystallization and some properties of argininosuccinate synthetase from rat liver
FEBS Lett.
58
314-317
1975
Rattus norvegicus
Saheki, T.; Kusumi, T.; Takada, S.; Katsunuma, T.
Studies of rat liver argininosuccinate synthetase. I. Physicochemical, catalytic, and immunochemical properties
J. Biochem.
81
687-696
1977
Rattus norvegicus
Rochovansky, O.; Kodowaki, H.; Ratner, S.
Biosynthesis of urea. Molecular and regulatory properties of crystalline argininosuccinate synthetase
J. Biol. Chem.
252
5287-5294
1977
Bos taurus
Matsuda, Y.; Tsuji, A.; Katunuma, N.; Hayashi, M.; Takahashi, Y.
Studies on liver argininosuccinate synthetase in a patient with citrullinemia and in normal subjects
J. Biochem.
85
191-195
1979
Homo sapiens
Hilger, F.; Simon, J.P.; Stalon, V.
Yeast argininosuccinate synthetase. Purification, structural and kinetic properties
Eur. J. Biochem.
94
153-163
1979
Saccharomyces cerevisiae, Saccharomyces cerevisiae 1278b
Takada, S.; Saheki, T.; Igarashi, Y.; Katsunuma, T.
Studies on rat liver argininosuccinate synthetase. Inhibition by various amino acids
J. Biochem.
85
1309-1314
1979
Rattus norvegicus
O'Brien, W.E.
Isolation and characterization of argininosuccinate synthetase from human liver
Biochemistry
18
5353-5356
1979
Homo sapiens
Takada, S.; Kusumi, T.; Saheki, T.; Tsuda, M.; Katsunuma, T.
Studies of rat liver argininosuccinate synthetase. The presence of three forms, and their physicochemical, catalytic, and immunochemical properties
J. Biochem.
86
1353-1359
1979
Rattus norvegicus
Kimball, M.E.; Jacoby, L.B.
Purification and properties of argininosuccinate synthetase from normal and canavanine-resistant human lymphoblasts
Biochemistry
19
705-709
1980
Homo sapiens
Saheki, T.; Tsuda, M.; Takada, S.; Kusumi, K.; Katsunuma, T.
Role of argininosuccinate synthetase in the regulation of urea synthesis in the rat and argininosuccinate synthetase-associated metabolic disorder in man
Adv. Enzyme Regul.
18
221-238
1986
Homo sapiens, Rattus norvegicus
Ratner, S.
Argininosuccinate synthetase of bovine liver: chemical and physical properties
Proc. Natl. Acad. Sci. USA
79
5197-5199
1982
Bos taurus
Saheki, T.; Sase, M.; Nakano, K.; Azuma, F.; Katsunuma, T.
Some properties of argininosuccinate synthetase purified from human liver and a comparison with the rat liver enzyme
J. Biochem.
93
1531-1537
1983
Homo sapiens, Rattus norvegicus
Raushell, F.M.; Seiglie, J.L.
Kinetic mechanism of argininosuccinate synthetase
Arch. Biochem. Biophys.
225
979-985
1983
Bos taurus
Raushel, F.M.
Nitro analogs of substrates for argininosuccinate synthetase and argininosuccinate lyase
Arch. Biochem. Biophys.
232
520-525
1984
Bos taurus
Kumar, S.; Lennane, J.; Ratner, S.
Argininosuccinate synthetase: essential role of cysteine and arginine residues in relation to structure and mechanism of ATP activation
Proc. Natl. Acad. Sci. USA
82
6745-6749
1985
Bos taurus
Isayama, H.; Nakamura, H.; Kanemura, H.; Kobayashi, K.; Emson, P.C.; Kawabuchi, M.; Tashiro, N.
Distribution and co-localization of nitric oxide synthetase and argininosuccinate synthetase in the cat hypothalamus
Arch. Histol. Cytol.
60
477-492
1997
Felis catus
Demarquoy, J.; Fairand, A.; Gautier, C.; Vaillant, T.
Regulation of argininosuccinate synthetase level by corticosteroid and pancreatic hormones during perinatal period
Mol. Cell. Biochem.
143
47-51
1995
Rattus norvegicus
Demarquoy, J.; Fairand, A.; Gautier, C.; Vaillant, R.
Demonstration of argininosuccinate synthetase activity associated with mitochondrial membrane: characterization and hormonal regulation
Mol. Cell. Biochem.
136
145-155
1994
Rattus norvegicus
Patejunas, G.; Bradley, A.; Beaudet, A.L.; O'Brien, W.E.
Generation of a mouse model for citrullinemia by targeted disruption of the argininosuccinate synthetase gene
Somat. Cell Mol. Genet.
20
55-60
1994
Mus musculus
Arnt-Ramos, L.R.; O'Brien, W.E.; Vincent, S.R.
Immunohistochemical localization of argininosuccinate synthetase in the rat brain in relation to nitric oxide synthase-containg neurons
Neuroscience
51
773-789
1992
Rattus norvegicus
Isahiki, Y.; Noda, T.; Kobayashi, K.; Sase, M.; Saheki, T.; Titani, K.
Identification of essential arginine residue(s) for Mg-ATP binding of human argininosuccinate synthetase
Protein Seq. Data Anal.
2
283-287
1989
Homo sapiens
Wakui, H.; Komatsuda, A.; Itoh, H.; Kobayashi, R.; Nakamoto, Y.; Miura, A.B.
Renal argininosuccinate synthetase: purification, immunohistochemical localization, and elastin-binding property
Renal Physiol. Biochem.
15
1-9
1992
Sus scrofa
Yu, Y.; Terada, K.; Nagasaki, A.; Takiguchi, M.; Mori, M.
Preparation of recombinant argininosuccinate synthetase and arguininosuccinate lyase: expression of the enzymes in rat tissues
J. Biochem.
117
952-957
1995
Rattus norvegicus
Shaheen, N.; Kobayashi, K.; Terazono, H.; Fukushige, T.; Horiuchi, M.; Saheki, T.
Characterization of human wild-type and mutant argininosuccinate synthetase proteins expressed in bacterial cells
Enzyme Protein
95
251-264
1994
Homo sapiens
Lemke, C.; Yeung, M.; Howell, P.L.
Expression, purification, crystallization and preliminary X-ray analysis of Escherichia coli argininosuccinate synthetase
Acta Crystallogr. Sect. D
55
2028-2030
1999
Escherichia coli
-
Shen, L.J.; Lin, W.C.; Beloussow, K.; Shen, W.C.
Resistance to the anti-proliferative activity of recombinant arginine deiminase in cell culture correlates with the endogenous enzyme, argininosuccinate synthetase
Cancer Lett.
191
165-170
2003
Canis lupus familiaris, Homo sapiens, Mus musculus
Van Geldre, L.A.; Timmermans, J.P.; Lefebvre, R.A.
L-citrulline recycling by argininosuccinate synthetase and lyase in rat gastric fundus
Eur. J. Pharmacol.
455
149-160
2002
Rattus norvegicus
Lemke, C.T.; Howell, P.L.
Substrate induced conformational changes in argininosuccinate synthetase
J. Biol. Chem.
277
13074-13081
2002
Escherichia coli
Goto, M.; Nakajima, Y.; Hirotsu, K.
Crystal structure of argininosuccinate synthetase from Thermus thermophilus HB8. Structural basis for the catalytic action
J. Biol. Chem.
277
15890-15896
2002
Thermus thermophilus, Thermus thermophilus HB8 / ATCC 27634 / DSM 579
Goto, M.; Omi, R.; Miyahara, I.; Sugahara, M.; Hirotsu, K.
Structures of argininosuccinate synthetase in enzyme-ATP substrates and enzyme-AMP product forms. Stereochemistry of the catalytic reaction
J. Biol. Chem.
278
22964-22971
2003
Thermus thermophilus (P59846), Thermus thermophilus, Thermus thermophilus HB8 / ATCC 27634 / DSM 579 (P59846)
Heneka, M.T.; Wiesinger, H.; Dumitrescu-Ozimek, L.; Riederer, P.; Feinstein, D.L.; Klockgether, T.
Neuronal and glial coexpression of argininosuccinate synthetase and inducible nitric oxide synthase in Alzheimer disease
J. Neuropathol. Exp. Neurol.
60
906-916
2001
Homo sapiens
Hukkanen, M.; Platts, L.A.M.; Haralambous, S.; Ainola, M.; Konttinen, Y.T.; Kollias, G.; Polak, J.M.
Induction of inducible nitric oxide synthase, argininosuccinate synthase, and GTP cyclohydrolase I in arthritic joints of human tumor necrosis factor-alpha transgenic mice
J. Rheumatol.
30
652-659
2003
Mus musculus
Kawahara, K.; Gotoh, T.; Oyadomari, S.; Kajizono, M.; Kuniyasu, A.; Ohsawa, K.; Imai, Y.; Kohsaka, S.; Nakayama, H.; Mori, M.
Co-induction of argininosuccinate synthetase, cationic amino acid transporter-2, and nitric oxide synthase in activated murine microglial cells
Mol. Brain Res.
90
165-173
2001
Mus musculus, Rattus norvegicus
Hammermann, R.; Bliesener, N.; Mossner, J.; Klasen, S.; Wiesinger, H.; Wessler, I.; Racke, K.
Inability of rat alveolar macrophages to recycle L-citrulline to L-arginine despite induction of argininosuccinate synthetase mRNA and protein, and inhibition of nitric oxide synthesis by exogenous L-citrulline
Naunyn Schmiedebergs Arch. Pharmacol.
358
601-607
1998
Rattus norvegicus
Brasse-Lagnel, C.; Lavoinne, A.; Fairand, A.; Vavasseur, K.; Husson, A.
IL-1beta stimulates argininosuccinate synthetase gene expression through NF-kappaB in Caco-2 cells
Biochimie
87
403-409
2005
Homo sapiens
Goodwin, B.L.; Solomonson, L.P.; Eichler, D.C.
Argininosuccinate synthase expression is required to maintain nitric oxide production and cell viability in aortic endothelial cells
J. Biol. Chem.
279
18353-18360
2004
Bos taurus
Hao, G.; Xie, L.; Gross, S.S.
Argininosuccinate synthetase is reversibly inactivated by S-nitrosylation in vitro and in vivo
J. Biol. Chem.
279
36192-36200
2004
Homo sapiens
Pendleton, L.C.; Goodwin, B.L.; Solomonson, L.P.; Eichler, D.C.
Regulation of endothelial argininosuccinate synthase expression and NO production by an upstream open reading frame
J. Biol. Chem.
280
24252-24260
2005
Bos taurus
Goodwin, B.L.; Pendleton, L.C.; Levy, M.M.; Solomonson, L.P.; Eichler, D.C.
Tumor necrosis factor-alpha reduces argininosuccinate synthase expression and nitric oxide production in aortic endothelial cells
Am. J. Physiol. Heart Circ. Physiol.
293
H1115-H1121
2007
Bos taurus
Brasse-Lagnel, C.; Lavoinne, A.; Fairand, A.; Vavasseur, K.; Deniel, N.; Husson, A.
Biphasic effect of IL-1beta on the activity of argininosuccinate synthetase in Caco-2 cells. Involvement of nitric oxide production
Biochimie
88
607-612
2006
Homo sapiens
Bizzoco, E.; Vannucchi, M.G.; Faussone-Pellegrini, M.S.
Transient ischemia increases neuronal nitric oxide synthase, argininosuccinate synthetase and argininosuccinate lyase co-expression in rat striatal neurons
Exp. Neurol.
204
252-259
2007
Rattus norvegicus
Szlosarek, P.W.; Grimshaw, M.J.; Wilbanks, G.D.; Hagemann, T.; Wilson, J.L.; Burke, F.; Stamp, G.; Balkwill, F.R.
Aberrant regulation of argininosuccinate synthetase by TNF-alpha in human epithelial ovarian cancer
Int. J. Cancer
121
6-11
2007
Homo sapiens
Kim, I.S.; Ki, C.S.; Kim, J.W.; Lee, M.; Jin, D.K.; Lee, S.Y.
Characterization of late-onset citrullinemia 1 in a Korean patient: confirmation by argininosuccinate synthetase gene mutation analysis
J. Biochem. Mol. Biol.
39
400-405
2006
Homo sapiens
Satoh, M.; Iwahori, T.; Sugawara, N.; Yamazaki, M.
Liver argininosuccinate synthase binds to bacterial lipopolysaccharides and lipid A and inactivates their biological activities
J. Endotoxin Res.
12
21-38
2006
Mus musculus
Endo, H.; Ootsuka, S.; Fukuda, S.; Kitade, Y.; Saga, N.
Functional complementation of an arginine auxotrophic yeast mutant by an argininosuccinate synthetase from Porphyra yezoensis (Rhodophyta)
J. Phycol.
42
1066-1071
2006
Neopyropia yezoensis (Q0KKQ0)
-
Wagemaker, M.J.; Eastwood, D.C.; van der Drift, C.; Jetten, M.S.; Burton, K.; Van Griensven, L.J.; Op den Camp, H.J.
Argininosuccinate synthetase and argininosuccinate lyase: two ornithine cycle enzymes from Agaricus bisporus
Mycol. Res.
111
493-502
2007
Agaricus bisporus (Q2Z0F6), Agaricus bisporus
Cruz, C.; Egsgaard, H.; Trujillo, C.; Ambus, P.; Requena, N.; Martins-Loucao, M.A.; Jakobsen, I.
Enzymatic evidence for the key role of arginine in nitrogen translocation by arbuscular mycorrhizal fungi
Plant Physiol.
144
782-792
2007
Daucus carota, Rhizophagus intraradices
Karlberg, T.; Collins, R.; van den Berg, S.; Flores, A.; Hammarstroem, M.; Hoegbom, M.; Holmberg Schiavone, L.; Uppenberg, J.
Structure of human argininosuccinate synthetase
Acta Crystallogr. Sect. D
64
279-286
2008
Homo sapiens (P00966), Homo sapiens
Goodwin, B.L.; Corbin, K.D.; Pendleton, L.C.; Levy, M.M.; Solomonson, L.P.; Eichler, D.C.
Troglitazone up-regulates vascular endothelial argininosuccinate synthase
Biochem. Biophys. Res. Commun.
370
254-258
2008
Bos taurus
Corbin, K.D.; Pendleton, L.C.; Solomonson, L.P.; Eichler, D.C.
Phosphorylation of argininosuccinate synthase by protein kinase A
Biochem. Biophys. Res. Commun.
377
1042-1046
2008
Bos taurus
Guei, T.R.; Liu, M.C.; Yang, C.P.; Su, T.S.
Identification of a liver-specific cAMP response element in the human argininosuccinate synthetase gene
Biochem. Biophys. Res. Commun.
377
257-261
2008
Homo sapiens
Satoh, M.; Ando, S.; Shinoda, T.; Yamazaki, M.
Clearance of bacterial lipopolysaccharides and lipid A by the liver and the role of argininosuccinate synthase
Innate Immun.
14
51-60
2008
Mus musculus
Bowles, T.L.; Kim, R.; Galante, J.; Parsons, C.M.; Virudachalam, S.; Kung, H.J.; Bold, R.J.
Pancreatic cancer cell lines deficient in argininosuccinate synthetase are sensitive to arginine deprivation by arginine deiminase
Int. J. Cancer
123
1950-1955
2008
Homo sapiens
Zhao, Y.; Zhang, J.; Li, H.; Li, Y.; Ren, J.; Luo, M.; Zheng, X.
An NADPH sensor protein (HSCARG) down-regulates nitric oxide synthesis by association with argininosuccinate synthetase and is essential for epithelial cell viability
J. Biol. Chem.
283
11004-11013
2008
Homo sapiens (P00966)
Larovere, L.E.; Angaroni, C.J.; Antonozzi, S.L.; Bezard, M.B.; Shimohama, M.; de Kremer, R.D.
Citrullinemia type I, classical variant. Identification of ASS-p~G390R (c.1168G>A) mutation in families of a limited geographic area of Argentina: a possible population cluster
Clin. Biochem.
42
1166-1168
2009
Homo sapiens (P00966), Homo sapiens
Ibarra-Gonzalez, I.; Fernandez-Lainez, C.; Vela-Amieva, M.
Clinical and biochemical characteristics of patients with urea cycle disorders in a developing country
Clin. Biochem.
43
461-466
2010
Homo sapiens
El Fadili, K.; Drummelsmith, J.; Roy, G.; Jardim, A.; Ouellette, M.
Down regulation of KMP-11 in Leishmania infantum axenic antimony resistant amastigotes as revealed by a proteomic screen
Exp. Parasitol.
123
51-57
2009
Leishmania infantum (A4I066), Leishmania infantum
Engel, K.; Hhne, W.; Hberle, J.
Mutations and polymorphisms in the human argininosuccinate synthetase (ASS1) gene
Hum. Mutat.
30
300-307
2009
Homo sapiens (P00966), Homo sapiens
Nicholson, L.J.; Smith, P.R.; Hiller, L.; Szlosarek, P.W.; Kimberley, C.; Sehouli, J.; Koensgen, D.; Mustea, A.; Schmid, P.; Crook, T.
Epigenetic silencing of argininosuccinate synthetase confers resistance to platinum-induced cell death but collateral sensitivity to arginine auxotrophy in ovarian cancer
Int. J. Cancer
125
1454-1463
2009
Homo sapiens
Delage, B.; Fennell, D.A.; Nicholson, L.; McNeish, I.; Lemoine, N.R.; Crook, T.; Szlosarek, P.W.
Arginine deprivation and argininosuccinate synthetase expression in the treatment of cancer
Int. J. Cancer
126
2762-2772
2010
Homo sapiens
Guerreiro, J.R.; Lameu, C.; Oliveira, E.F.; Klitzke, C.F.; Melo, R.L.; Linares, E.; Augusto, O.; Fox, J.W.; Lebrun, I.; Serrano, S.M.; Camargo, A.C.
Argininosuccinate synthetase is a functional target for a snake venom anti-hypertensive peptide: role in arginine and nitric oxide production
J. Biol. Chem.
284
20022-20033
2009
Homo sapiens, Mus musculus (P16460)
Nagasaka, H.; Tsukahara, H.; Yorifuji, T.; Miida, T.; Murayama, K.; Tsuruoka, T.; Takatani, T.; Kanazawa, M.; Kobayashi, K.; Okano, Y.; Takayanagi, M.
Evaluation of endogenous nitric oxide synthesis in congenital urea cycle enzyme defects
Metab. Clin. Exp.
58
278-282
2009
Homo sapiens
Prima, V.; Wang, A.; Molina, G.; Wang, K.K.; Svetlov, S.I.
Inhibition of LPS toxicity by hepatic argininosuccinate synthase (ASS): Novel roles for ASS in innate immune responses to bacterial infection
Int. Immunopharmacol.
11
1180-1188
2011
Mus musculus, Homo sapiens (P00966)
Mun, G.I.; Kim, I.S.; Lee, B.H.; Boo, Y.C.
Endothelial argininosuccinate synthetase 1 regulates nitric oxide production and monocyte adhesion under static and laminar shear stress conditions
J. Biol. Chem.
286
2536-2542
2011
Homo sapiens (P00966), Homo sapiens
Van de Casteele, M.; Demarez, M.; Legrain, C.; Glansdorff, N.; Pierard, A.
Pathways of arginine biosynthesis in extreme thermophilic archaeo- and eubacteria
J. Gen. Microbiol.
136
1177-1183
1990
Pyrococcus furiosus, Saccharolobus solfataricus, Saccharolobus solfataricus P1
-
Lakhal-Naouar, I.; Jardim, A.; Strasser, R.; Luo, S.; Kozakai, Y.; Nakhasi, H.L.; Duncan, R.C.
Leishmania donovani argininosuccinate synthase is an active enzyme associated with parasite pathogenesis
PLoS Negl. Trop. Dis.
6
e1849
2012
Leishmania donovani (H9BG20), Leishmania donovani
Bateman, L.A.; Ku, W.M.; Heslin, M.J.; Contreras, C.M.; Skibola, C.F.; Nomura, D.K.
Argininosuccinate synthase 1 is a metabolic regulator of colorectal cancer pathogenicity
ACS Chem. Biol.
12
905-911
2017
Homo sapiens (P00966), Homo sapiens
Lu, Y.; Ward, S.; Nieto, N.
Ethanol plus the Jo2 fas agonistic antibody-induced liver injury is attenuated in mice with partial ablation of argininosuccinate synthase
Alcoholism
38
649-656
2014
Mus musculus (P16460)
Wu, D.; Peng, Y.; Zhou, J.; Yang, Y.T.; Rao, C.L.; Bai, S.J.; Zhou, X.Y.; Chen, J.; Liao, L.; Liang, Z.H.; Yang, D.Y.; Xie, P.
Identification and validation of argininosuccinate synthase as a candidate urinary biomarker for major depressive disorder
Clin. Chim. Acta
451
142-148
2015
Homo sapiens (P00966)
Henriet, E.; Abou Hammoud, A.; Dupuy, J.W.; Dartigues, B.; Ezzoukry, Z.; Dugot-Senant, N.; Leste-Lasserre, T.; Pallares-Lupon, N.; Nikolski, M.; Le Bail, B.; Blanc, J.F.; Balabaud, C.; Bioulac-Sage, P.; Raymond, A.A.; Saltel, F.
Argininosuccinate synthase 1 (ASS1) A marker of unclassified hepatocellular adenoma and high bleeding risk
Hepatology
66
2016-2028
2017
Homo sapiens (P00966)
Chng, Y.R.; Ong, J.L.; Ching, B.; Chen, X.L.; Wong, W.P.; Chew, S.F.; Ip, Y.K.
Molecular characterization of argininosuccinate synthase and argininosuccinate lyase from the liver of the African lungfish Protopterus annectens, and their mRNA expression levels in the liver, kidney, brain and skeletal muscle during aestivation
J. Comp. Physiol. B
184
835-853
2014
Protopterus annectens (S4V5K7), Protopterus annectens
Huang, Z.; Wang, T.S.; Zhao, Y.C.; Zuo, R.J.; Deng, W.B.; Chi, Y.J.; Yang, Z.M.
Cyclic adenosine monophosphate-induced argininosuccinate synthase 1 expression is essential during mouse decidualization
Mol. Cell. Endocrinol.
388
20-31
2014
Mus musculus (P16460), Mus musculus
Miyamoto, T.; Lo, P.H.Y.; Saichi, N.; Ueda, K.; Hirata, M.; Tanikawa, C.; Matsuda, K.
Argininosuccinate synthase 1 is an intrinsic Akt repressor transactivated by p53
Sci. Adv.
3
e1603204
2017
Mus musculus (P16460)
Sardar, A.; Jardim, A.; Ghosh, A.; Mandal, A.; Das, S.; Saini, S.; Abhishek, K.; Singh, R.; Verma, S.; Kumar, A.; Das, P.
Genetic manipulation of Leishmania donovani to explore the involvement of argininosuccinate synthase in oxidative stress management
PLoS Negl. Trop. Dis.
10
e0004308
2016
Leishmania donovani (H9BG20), Leishmania donovani, Leishmania donovani AG83 (H9BG20)
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