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Information on EC 6.3.4.4 - adenylosuccinate synthase and Organism(s) Sus scrofa and UniProt Accession A4Z6H0

for references in articles please use BRENDA:EC6.3.4.4
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EC Tree
     6 Ligases
         6.3 Forming carbon-nitrogen bonds
             6.3.4 Other carbon-nitrogen ligases
                6.3.4.4 adenylosuccinate synthase
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Select one or more organisms in this record: ?
This record set is specific for:
Sus scrofa
UNIPROT: A4Z6H0 not found.
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Word Map
The taxonomic range for the selected organisms is: Sus scrofa
The enzyme appears in selected viruses and cellular organisms
Synonyms
adenylosuccinate synthetase, adssl1, adss1, adenylosuccinate synthase, pfadss, adss2, ampss, succino-amp synthetase, adenylosuccinate synthetase 1, mouse muscle synthetase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Adenylosuccinate synthase
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-
-
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Adenylosuccinate synthetase
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-
-
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AdSS
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-
-
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AMPSase
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-
-
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IMP--aspartate ligase
-
-
-
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IMP-aspartate ligase
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-
-
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Succino-AMP synthetase
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-
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Succinoadenylic kinosynthetase
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-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
amination
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-
-
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SYSTEMATIC NAME
IUBMB Comments
IMP:L-aspartate ligase (GDP-forming)
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CAS REGISTRY NUMBER
COMMENTARY hide
9023-57-8
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
GTP + IMP + L-Asp
GDP + phosphate + adenylosuccinate
show the reaction diagram
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-
-
?
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
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-
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
additional information
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overview
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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.23
Asp
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-
0.011
GTP
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pI VALUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
8.7
calculated from sequence
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
SwissProt
Manually annotated by BRENDA team
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
low level
Manually annotated by BRENDA team
ADSS1 is predominantly expressed in the striated muscle tissue, ADSS1 is up-regulated significantly along with muscle growth
Manually annotated by BRENDA team
weak expression level of ADSS2 mRNA
Manually annotated by BRENDA team
high expression level of ADSS2 mRNA
Manually annotated by BRENDA team
high expression level of ADSS2 mRNA
Manually annotated by BRENDA team
high expression level of ADSS2 mRNA
Manually annotated by BRENDA team
high expression level of ADSS2 mRNA
Manually annotated by BRENDA team
weak expression level of ADSS2 mRNA
Manually annotated by BRENDA team
high expression level of ADSS2 mRNA
Manually annotated by BRENDA team
high expression level of ADSS2 mRNA
Manually annotated by BRENDA team
additional information
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
PURA1_PIG
457
0
50098
Swiss-Prot
Mitochondrion (Reliability: 5)
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Stayton, M.M.; Rudolph, F.B.; Fromm, H.J.
Regulation, genetics, and properties of adenylosuccinate synthetase
Curr. Top. Cell. Regul.
22
103-141
1983
Azotobacter vinelandii, Bacillus subtilis, Gallus gallus, Oryctolagus cuniculus, Escherichia coli, Homo sapiens, Leishmania donovani, Rattus norvegicus, Schizosaccharomyces pombe, Sus scrofa, Triticum aestivum, Trypanosoma cruzi
Manually annotated by BRENDA team
Li, X.; Zhu, Z.; Mo, D.; Wang, H.; Yang, S.; Zhao, S.; Li, K.
Comparative molecular characterization of ADSS1 and ADSS2 genes in pig (Sus scrofa)
Comp. Biochem. Physiol. B
147B
271-277
2007
Sus scrofa (A4Z6H0), Sus scrofa (A4Z6H1)
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Manually annotated by BRENDA team