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(R,S)-tetrahydrofolate + ATP + formate
?
-
-
-
r
ADP + carbamoylphosphate + tetrahydrofolate
ATP + ?
-
-
-
?
ADP + phosphate + 10-formyltetrahydrofolate
?
ATP + (6R,S)-tetrahydrofolate pteroylpentaglutamate
ADP + phosphate + 10-formyltetrahydrofolate pteroylpentaglutamate
-
-
-
-
?
ATP + (6R,S)-tetrahydrofolate pteroyltriglutamate
ADP + phosphate + 10-formyltetrahydrofolate pteroyltriglutamate
-
-
-
-
?
ATP + formate
ADP + HCOOPO32-
ATP + formate + (6R,S)-5,6,7,8-tetrahydrofolate
ADP + phosphate + 10-formyltetrahydrofolate
ATP + formate + (6R,S)-tetrahydrofolate
ADP + phosphate + 10-formyltetrahydrofolate
ATP + formate + (6R,S)-tetrahydrofolate monoglutamate
ADP + phosphate + 10-formyltetrahydrofolate monoglutamate
-
-
-
-
?
ATP + formate + 5,6,7,8-tetrahydropteroyldiglutamate
ADP + phosphate + 10-formyltetrahydrofolyldiglutamate
ATP + formate + 5,6,7,8-tetrahydropteroylpentaglutamate
ADP + phosphate + 10-formyltetrahydrofolylpentaglutamate
-
-
-
-
?
ATP + formate + 5,6,7,8-tetrahydropteroyltetraglutamate
ADP + phosphate + 10-formyltetrahydrofolyltetraglutamate
-
-
-
-
?
ATP + formate + 5,6,7,8-tetrahydropteroyltriglutamate
ADP + phosphate + 10-formyltetrahydrofolyltriglutamate
ATP + formate + tetrahydrofolate
?
ATP + formate + tetrahydrofolate
ADP + phosphate + 10-formyltetrahydrofolate
ATP + formate + tetrahydropteroyl-(Glu)n
ADP + phosphate + 10-formyltetrahydropteroyl-(Glu)n
Carbamoyl phosphate + ADP
? + ATP
dATP + formate + tetrahydrofolate
dADP + phosphate + 10-formyltetrahydrofolate
-
37% of the activity relative to ATP
-
-
?
formate + ATP + tetrahydrofolate
10-formyltetrahydrofolate + ADP + phosphate
synthetase activity of MTHFD1
-
-
?
tetrahydrofolate + formate + ATP
10-formyltetrahydrofolate + ADP + phosphate
additional information
?
-
ADP + phosphate + 10-formyltetrahydrofolate
?
Clostridium acidi-urici
-
ATP production. The relative concentration of formylated and unformylated folate coenzymes may be a significant regulatory parameter in the purine-fermenting Clostridia
-
-
?
ADP + phosphate + 10-formyltetrahydrofolate
?
-
ATP production. The relative concentration of formylated and unformylated folate coenzymes may be a significant regulatory parameter in the purine-fermenting Clostridia
-
-
?
ATP + formate
ADP + HCOOPO32-
-
formate kinase reaction, sequential random bi bi mechanism
-
?
ATP + formate
ADP + HCOOPO32-
-
formate kinase reaction, sequential random bi bi mechanism
-
?
ATP + formate + (6R,S)-5,6,7,8-tetrahydrofolate
ADP + phosphate + 10-formyltetrahydrofolate
-
-
-
?
ATP + formate + (6R,S)-5,6,7,8-tetrahydrofolate
ADP + phosphate + 10-formyltetrahydrofolate
-
-
-
?
ATP + formate + (6R,S)-tetrahydrofolate
ADP + phosphate + 10-formyltetrahydrofolate
-
-
-
?
ATP + formate + (6R,S)-tetrahydrofolate
ADP + phosphate + 10-formyltetrahydrofolate
-
-
-
?
ATP + formate + 5,6,7,8-tetrahydropteroyldiglutamate
ADP + phosphate + 10-formyltetrahydrofolyldiglutamate
-
-
-
-
?
ATP + formate + 5,6,7,8-tetrahydropteroyldiglutamate
ADP + phosphate + 10-formyltetrahydrofolyldiglutamate
-
-
-
-
?
ATP + formate + 5,6,7,8-tetrahydropteroyltriglutamate
ADP + phosphate + 10-formyltetrahydrofolyltriglutamate
-
-
-
-
?
ATP + formate + 5,6,7,8-tetrahydropteroyltriglutamate
ADP + phosphate + 10-formyltetrahydrofolyltriglutamate
-
-
-
-
?
ATP + formate + 5,6,7,8-tetrahydropteroyltriglutamate
ADP + phosphate + 10-formyltetrahydrofolyltriglutamate
-
-
-
-
?
ATP + formate + tetrahydrofolate
?
Clostridium acidi-urici
-
two different physiological roles: 1. Functions anabolically in most organisms to activate formate via the forward reaction, and brings it into the one-carbon metabolic pool as N10-formyltetrahydrofolate, 2. In purine-fermenting bacteria the enzyme probably functions catabolically in the terminal step of the purine degradative pathway. This reaction may be responsible for ATP production in these organisms
-
-
?
ATP + formate + tetrahydrofolate
?
Clostridium acidi-urici
-
the enzyme is responsible for the recruitment of single carbon units from the formate pool into a variety of folate-dependent biosynthetic pathways
-
-
?
ATP + formate + tetrahydrofolate
?
-
two different physiological roles: 1. Functions anabolically in most organisms to activate formate via the forward reaction, and brings it into the one-carbon metabolic pool as N10-formyltetrahydrofolate, 2. In purine-fermenting bacteria the enzyme probably functions catabolically in the terminal step of the purine degradative pathway. This reaction may be responsible for ATP production in these organisms
-
-
?
ATP + formate + tetrahydrofolate
?
-
two different physiological roles: 1. Functions anabolically in most organisms to activate formate via the forward reaction, and brings it into the one-carbon metabolic pool as N10-formyltetrahydrofolate, 2. In purine-fermenting bacteria the enzyme probably functions catabolically in the terminal step of the purine degradative pathway. This reaction may be responsible for ATP production in these organisms
-
-
?
ATP + formate + tetrahydrofolate
?
-
two different physiological roles: 1. Functions anabolically in most organisms to activate formate via the forward reaction, and brings it into the one-carbon metabolic pool as N10-formyltetrahydrofolate, 2. In purine-fermenting bacteria the enzyme probably functions catabolically in the terminal step of the purine degradative pathway. This reaction may be responsible for ATP production in these organisms
-
-
?
ATP + formate + tetrahydrofolate
?
-
two different physiological roles: 1. Functions anabolically in most organisms to activate formate via the forward reaction, and brings it into the one-carbon metabolic pool as N10-formyltetrahydrofolate, 2. In purine-fermenting bacteria the enzyme probably functions catabolically in the terminal step of the purine degradative pathway. This reaction may be responsible for ATP production in these organisms
-
-
?
ATP + formate + tetrahydrofolate
?
-
two different physiological roles: 1. Functions anabolically in most organisms to activate formate via the forward reaction, and brings it into the one-carbon metabolic pool as N10-formyltetrahydrofolate, 2. In purine-fermenting bacteria the enzyme probably functions catabolically in the terminal step of the purine degradative pathway. This reaction may be responsible for ATP production in these organisms
-
-
?
ATP + formate + tetrahydrofolate
?
-
two different physiological roles: 1. Functions anabolically in most organisms to activate formate via the forward reaction, and brings it into the one-carbon metabolic pool as N10-formyltetrahydrofolate, 2. In purine-fermenting bacteria the enzyme probably functions catabolically in the terminal step of the purine degradative pathway. This reaction may be responsible for ATP production in these organisms
-
-
?
ATP + formate + tetrahydrofolate
?
-
two different physiological roles: 1. Functions anabolically in most organisms to activate formate via the forward reaction, and brings it into the one-carbon metabolic pool as N10-formyltetrahydrofolate, 2. In purine-fermenting bacteria the enzyme probably functions catabolically in the terminal step of the purine degradative pathway. This reaction may be responsible for ATP production in these organisms
-
-
?
ATP + formate + tetrahydrofolate
?
-
two different physiological roles: 1. Functions anabolically in most organisms to activate formate via the forward reaction, and brings it into the one-carbon metabolic pool as N10-formyltetrahydrofolate, 2. In purine-fermenting bacteria the enzyme probably functions catabolically in the terminal step of the purine degradative pathway. This reaction may be responsible for ATP production in these organisms
-
-
?
ATP + formate + tetrahydrofolate
?
-
rate-determining step in the conversion of formate to Ser
-
-
?
ATP + formate + tetrahydrofolate
?
-
two different physiological roles: 1. Functions anabolically in most organisms to activate formate via the forward reaction, and brings it into the one-carbon metabolic pool as N10-formyltetrahydrofolate, 2. In purine-fermenting bacteria the enzyme probably functions catabolically in the terminal step of the purine degradative pathway. This reaction may be responsible for ATP production in these organisms
-
-
?
ATP + formate + tetrahydrofolate
?
-
the trifunctional enzyme is involved in the interconversion of one-carbon adducts of tetrahydrofolate
-
-
?
ATP + formate + tetrahydrofolate
?
Pigeon
-
two different physiological roles: 1. Functions anabolically in most organisms to activate formate via the forward reaction, and brings it into the one-carbon metabolic pool as N10-formyltetrahydrofolate, 2. In purine-fermenting bacteria the enzyme probably functions catabolically in the terminal step of the purine degradative pathway. This reaction may be responsible for ATP production in these organisms
-
-
?
ATP + formate + tetrahydrofolate
?
-
two different physiological roles: 1. Functions anabolically in most organisms to activate formate via the forward reaction, and brings it into the one-carbon metabolic pool as N10-formyltetrahydrofolate, 2. In purine-fermenting bacteria the enzyme probably functions catabolically in the terminal step of the purine degradative pathway. This reaction may be responsible for ATP production in these organisms
-
-
?
ATP + formate + tetrahydrofolate
?
-
two different physiological roles: 1. Functions anabolically in most organisms to activate formate via the forward reaction, and brings it into the one-carbon metabolic pool as N10-formyltetrahydrofolate, 2. In purine-fermenting bacteria the enzyme probably functions catabolically in the terminal step of the purine degradative pathway. This reaction may be responsible for ATP production in these organisms
-
-
?
ATP + formate + tetrahydrofolate
?
-
two different physiological roles: 1. Functions anabolically in most organisms to activate formate via the forward reaction, and brings it into the one-carbon metabolic pool as N10-formyltetrahydrofolate, 2. In purine-fermenting bacteria the enzyme probably functions catabolically in the terminal step of the purine degradative pathway. This reaction may be responsible for ATP production in these organisms
-
-
?
ATP + formate + tetrahydrofolate
?
-
two different physiological roles: 1. Functions anabolically in most organisms to activate formate via the forward reaction, and brings it into the one-carbon metabolic pool as N10-formyltetrahydrofolate, 2. In purine-fermenting bacteria the enzyme probably functions catabolically in the terminal step of the purine degradative pathway. This reaction may be responsible for ATP production in these organisms
-
-
?
ATP + formate + tetrahydrofolate
?
-
the trifunctional enzyme is involved in the interconversion of one-carbon adducts of tetrahydrofolate
-
-
?
ATP + formate + tetrahydrofolate
?
-
enzyme of one-carbon metabolism
-
-
?
ATP + formate + tetrahydrofolate
?
-
two different physiological roles: 1. Functions anabolically in most organisms to activate formate via the forward reaction, and brings it into the one-carbon metabolic pool as N10-formyltetrahydrofolate, 2. In purine-fermenting bacteria the enzyme probably functions catabolically in the terminal step of the purine degradative pathway. This reaction may be responsible for ATP production in these organisms
-
-
?
ATP + formate + tetrahydrofolate
?
-
the trifunctional enzyme is involved in the interconversion of one-carbon adducts of tetrahydrofolate
-
-
?
ATP + formate + tetrahydrofolate
?
-
two different physiological roles: 1. Functions anabolically in most organisms to activate formate via the forward reaction, and brings it into the one-carbon metabolic pool as N10-formyltetrahydrofolate, 2. In purine-fermenting bacteria the enzyme probably functions catabolically in the terminal step of the purine degradative pathway. This reaction may be responsible for ATP production in these organisms
-
-
?
ATP + formate + tetrahydrofolate
ADP + phosphate + 10-formyltetrahydrofolate
-
-
-
?
ATP + formate + tetrahydrofolate
ADP + phosphate + 10-formyltetrahydrofolate
-
-
-
?
ATP + formate + tetrahydrofolate
ADP + phosphate + 10-formyltetrahydrofolate
-
-
-
?
ATP + formate + tetrahydrofolate
ADP + phosphate + 10-formyltetrahydrofolate
-
-
-
?
ATP + formate + tetrahydrofolate
ADP + phosphate + 10-formyltetrahydrofolate
-
-
-
?
ATP + formate + tetrahydrofolate
ADP + phosphate + 10-formyltetrahydrofolate
Clostridium acidi-urici
-
-
-
?
ATP + formate + tetrahydrofolate
ADP + phosphate + 10-formyltetrahydrofolate
Clostridium acidi-urici
-
-
-
?
ATP + formate + tetrahydrofolate
ADP + phosphate + 10-formyltetrahydrofolate
Clostridium acidi-urici
-
-
-
?
ATP + formate + tetrahydrofolate
ADP + phosphate + 10-formyltetrahydrofolate
Clostridium acidi-urici
-
-
-
?
ATP + formate + tetrahydrofolate
ADP + phosphate + 10-formyltetrahydrofolate
Clostridium acidi-urici
-
-
-
?
ATP + formate + tetrahydrofolate
ADP + phosphate + 10-formyltetrahydrofolate
Clostridium acidi-urici
-
-
-
?
ATP + formate + tetrahydrofolate
ADP + phosphate + 10-formyltetrahydrofolate
Clostridium acidi-urici
-
-
-
?
ATP + formate + tetrahydrofolate
ADP + phosphate + 10-formyltetrahydrofolate
Clostridium acidi-urici 9a
-
-
-
?
ATP + formate + tetrahydrofolate
ADP + phosphate + 10-formyltetrahydrofolate
-
-
-
?
ATP + formate + tetrahydrofolate
ADP + phosphate + 10-formyltetrahydrofolate
-
-
-
?
ATP + formate + tetrahydrofolate
ADP + phosphate + 10-formyltetrahydrofolate
-
-
-
?
ATP + formate + tetrahydrofolate
ADP + phosphate + 10-formyltetrahydrofolate
-
-
-
?
ATP + formate + tetrahydrofolate
ADP + phosphate + 10-formyltetrahydrofolate
-
-
-
?
ATP + formate + tetrahydrofolate
ADP + phosphate + 10-formyltetrahydrofolate
-
-
-
?
ATP + formate + tetrahydrofolate
ADP + phosphate + 10-formyltetrahydrofolate
-
-
-
?
ATP + formate + tetrahydrofolate
ADP + phosphate + 10-formyltetrahydrofolate
-
-
-
?
ATP + formate + tetrahydrofolate
ADP + phosphate + 10-formyltetrahydrofolate
-
-
-
?
ATP + formate + tetrahydrofolate
ADP + phosphate + 10-formyltetrahydrofolate
-
r
-
?
ATP + formate + tetrahydrofolate
ADP + phosphate + 10-formyltetrahydrofolate
-
r
-
?
ATP + formate + tetrahydrofolate
ADP + phosphate + 10-formyltetrahydrofolate
-
r
-
?
ATP + formate + tetrahydrofolate
ADP + phosphate + 10-formyltetrahydrofolate
-
ATP in form of MgATP2-
-
-
?
ATP + formate + tetrahydrofolate
ADP + phosphate + 10-formyltetrahydrofolate
-
-
-
?
ATP + formate + tetrahydrofolate
ADP + phosphate + 10-formyltetrahydrofolate
-
-
-
?
ATP + formate + tetrahydrofolate
ADP + phosphate + 10-formyltetrahydrofolate
-
-
-
?
ATP + formate + tetrahydrofolate
ADP + phosphate + 10-formyltetrahydrofolate
-
-
-
?
ATP + formate + tetrahydrofolate
ADP + phosphate + 10-formyltetrahydrofolate
-
-
-
?
ATP + formate + tetrahydrofolate
ADP + phosphate + 10-formyltetrahydrofolate
-
-
-
-
?
ATP + formate + tetrahydrofolate
ADP + phosphate + 10-formyltetrahydrofolate
-
-
-
?
ATP + formate + tetrahydrofolate
ADP + phosphate + 10-formyltetrahydrofolate
-
-
-
?
ATP + formate + tetrahydrofolate
ADP + phosphate + 10-formyltetrahydrofolate
-
-
-
?
ATP + formate + tetrahydrofolate
ADP + phosphate + 10-formyltetrahydrofolate
-
-
-
?
ATP + formate + tetrahydrofolate
ADP + phosphate + 10-formyltetrahydrofolate
-
-
-
?
ATP + formate + tetrahydrofolate
ADP + phosphate + 10-formyltetrahydrofolate
-
-
-
?
ATP + formate + tetrahydrofolate
ADP + phosphate + 10-formyltetrahydrofolate
-
-
-
?
ATP + formate + tetrahydrofolate
ADP + phosphate + 10-formyltetrahydrofolate
-
-
-
?
ATP + formate + tetrahydrofolate
ADP + phosphate + 10-formyltetrahydrofolate
-
-
-
?
ATP + formate + tetrahydrofolate
ADP + phosphate + 10-formyltetrahydrofolate
-
-
-
?
ATP + formate + tetrahydrofolate
ADP + phosphate + 10-formyltetrahydrofolate
-
-
-
-
?
ATP + formate + tetrahydrofolate
ADP + phosphate + 10-formyltetrahydrofolate
-
-
?
ATP + formate + tetrahydrofolate
ADP + phosphate + 10-formyltetrahydrofolate
-
-
-
?
ATP + formate + tetrahydrofolate
ADP + phosphate + 10-formyltetrahydrofolate
-
-
-
?
ATP + formate + tetrahydrofolate
ADP + phosphate + 10-formyltetrahydrofolate
trifuntional enzyme having 10-formyl-tetrahydrofolate synthetase, 5,10-methylene-tetrahydrofolate cyclohydrolase and 5,10-methylene-tetrahydrofolate dehydrogenase activity
-
?
ATP + formate + tetrahydrofolate
ADP + phosphate + 10-formyltetrahydrofolate
-
-
?
ATP + formate + tetrahydrofolate
ADP + phosphate + 10-formyltetrahydrofolate
FtfL activity is required for methylotrophic growth
-
?
ATP + formate + tetrahydrofolate
ADP + phosphate + 10-formyltetrahydrofolate
-
-
?
ATP + formate + tetrahydrofolate
ADP + phosphate + 10-formyltetrahydrofolate
FtfL activity is required for methylotrophic growth
-
?
ATP + formate + tetrahydrofolate
ADP + phosphate + 10-formyltetrahydrofolate
-
-
-
?
ATP + formate + tetrahydrofolate
ADP + phosphate + 10-formyltetrahydrofolate
-
-
-
?
ATP + formate + tetrahydrofolate
ADP + phosphate + 10-formyltetrahydrofolate
-
-
-
?
ATP + formate + tetrahydrofolate
ADP + phosphate + 10-formyltetrahydrofolate
-
-
-
?
ATP + formate + tetrahydrofolate
ADP + phosphate + 10-formyltetrahydrofolate
-
-
-
?
ATP + formate + tetrahydrofolate
ADP + phosphate + 10-formyltetrahydrofolate
-
-
-
?
ATP + formate + tetrahydrofolate
ADP + phosphate + 10-formyltetrahydrofolate
-
-
-
?
ATP + formate + tetrahydrofolate
ADP + phosphate + 10-formyltetrahydrofolate
-
-
-
?
ATP + formate + tetrahydrofolate
ADP + phosphate + 10-formyltetrahydrofolate
-
-
?
ATP + formate + tetrahydrofolate
ADP + phosphate + 10-formyltetrahydrofolate
-
-
?
ATP + formate + tetrahydrofolate
ADP + phosphate + 10-formyltetrahydrofolate
-
-
-
?
ATP + formate + tetrahydrofolate
ADP + phosphate + 10-formyltetrahydrofolate
-
r
-
?
ATP + formate + tetrahydrofolate
ADP + phosphate + 10-formyltetrahydrofolate
-
r
-
?
ATP + formate + tetrahydrofolate
ADP + phosphate + 10-formyltetrahydrofolate
-
-
-
?
ATP + formate + tetrahydrofolate
ADP + phosphate + 10-formyltetrahydrofolate
-
-
-
?
ATP + formate + tetrahydrofolate
ADP + phosphate + 10-formyltetrahydrofolate
-
-
-
-
?
ATP + formate + tetrahydrofolate
ADP + phosphate + 10-formyltetrahydrofolate
-
-
-
r
ATP + formate + tetrahydrofolate
ADP + phosphate + 10-formyltetrahydrofolate
flow of one-carbon units through cytoplasmic and mitochondrial folate pathways, overview
-
-
r
ATP + formate + tetrahydrofolate
ADP + phosphate + 10-formyltetrahydrofolate
-
-
-
?
ATP + formate + tetrahydrofolate
ADP + phosphate + 10-formyltetrahydrofolate
-
-
-
?
ATP + formate + tetrahydrofolate
ADP + phosphate + 10-formyltetrahydrofolate
-
-
-
?
ATP + formate + tetrahydrofolate
ADP + phosphate + 10-formyltetrahydrofolate
-
-
-
?
ATP + formate + tetrahydrofolate
ADP + phosphate + 10-formyltetrahydrofolate
-
-
-
?
ATP + formate + tetrahydrofolate
ADP + phosphate + 10-formyltetrahydrofolate
-
ATP in form of MgATP2-
-
-
?
ATP + formate + tetrahydrofolate
ADP + phosphate + 10-formyltetrahydrofolate
-
-
-
?
ATP + formate + tetrahydrofolate
ADP + phosphate + 10-formyltetrahydrofolate
-
-
-
?
ATP + formate + tetrahydrofolate
ADP + phosphate + 10-formyltetrahydrofolate
-
ATP in form of MgATP2-
-
-
?
ATP + formate + tetrahydrofolate
ADP + phosphate + 10-formyltetrahydrofolate
-
-
-
?
ATP + formate + tetrahydrofolate
ADP + phosphate + 10-formyltetrahydrofolate
-
-
-
?
ATP + formate + tetrahydrofolate
ADP + phosphate + 10-formyltetrahydrofolate
-
-
-
?
ATP + formate + tetrahydrofolate
ADP + phosphate + 10-formyltetrahydrofolate
Pigeon
-
-
-
?
ATP + formate + tetrahydrofolate
ADP + phosphate + 10-formyltetrahydrofolate
-
-
-
?
ATP + formate + tetrahydrofolate
ADP + phosphate + 10-formyltetrahydrofolate
-
-
-
?
ATP + formate + tetrahydrofolate
ADP + phosphate + 10-formyltetrahydrofolate
-
-
-
?
ATP + formate + tetrahydrofolate
ADP + phosphate + 10-formyltetrahydrofolate
-
ATP in form of MgATP2-
-
-
?
ATP + formate + tetrahydrofolate
ADP + phosphate + 10-formyltetrahydrofolate
-
-
-
?
ATP + formate + tetrahydrofolate
ADP + phosphate + 10-formyltetrahydrofolate
-
-
-
?
ATP + formate + tetrahydrofolate
ADP + phosphate + 10-formyltetrahydrofolate
-
-
-
?
ATP + formate + tetrahydrofolate
ADP + phosphate + 10-formyltetrahydrofolate
-
-
-
?
ATP + formate + tetrahydrofolate
ADP + phosphate + 10-formyltetrahydrofolate
-
-
-
?
ATP + formate + tetrahydrofolate
ADP + phosphate + 10-formyltetrahydrofolate
-
-
-
?
ATP + formate + tetrahydrofolate
ADP + phosphate + 10-formyltetrahydrofolate
-
-
-
?
ATP + formate + tetrahydrofolate
ADP + phosphate + 10-formyltetrahydrofolate
-
-
-
-
?
ATP + formate + tetrahydrofolate
ADP + phosphate + 10-formyltetrahydrofolate
-
-
-
-
?
ATP + formate + tetrahydrofolate
ADP + phosphate + 10-formyltetrahydrofolate
-
-
-
?
ATP + formate + tetrahydrofolate
ADP + phosphate + 10-formyltetrahydrofolate
-
-
-
?
ATP + formate + tetrahydrofolate
ADP + phosphate + 10-formyltetrahydrofolate
-
-
-
?
ATP + formate + tetrahydrofolate
ADP + phosphate + 10-formyltetrahydrofolate
-
ATP in form of MgATP2-
-
-
?
ATP + formate + tetrahydrofolate
ADP + phosphate + 10-formyltetrahydrofolate
-
-
-
?
ATP + formate + tetrahydrofolate
ADP + phosphate + 10-formyltetrahydrofolate
-
-
-
?
ATP + formate + tetrahydrofolate
ADP + phosphate + 10-formyltetrahydrofolate
-
-
-
?
ATP + formate + tetrahydrofolate
ADP + phosphate + 10-formyltetrahydrofolate
-
-
-
?
ATP + formate + tetrahydrofolate
ADP + phosphate + 10-formyltetrahydrofolate
-
-
-
?
ATP + formate + tetrahydrofolate
ADP + phosphate + 10-formyltetrahydrofolate
-
-
-
?
ATP + formate + tetrahydrofolate
ADP + phosphate + 10-formyltetrahydrofolate
-
ATP in form of MgATP2-
-
-
?
ATP + formate + tetrahydrofolate
ADP + phosphate + 10-formyltetrahydrofolate
-
-
-
?
ATP + formate + tetrahydrofolate
ADP + phosphate + 10-formyltetrahydrofolate
-
-
-
?
ATP + formate + tetrahydrofolate
ADP + phosphate + 10-formyltetrahydrofolate
A7BK03, A7BK04, A7BK05, A7BK06, A7BK07, A7BK08, A7BK09, A7BK10, A7BK11, A7BK12, A7BK13, A7BK14, A7BK15, A7BK16, A7BK17 -
-
-
?
ATP + formate + tetrahydrofolate
ADP + phosphate + 10-formyltetrahydrofolate
-
-
-
?
ATP + formate + tetrahydrofolate
ADP + phosphate + 10-formyltetrahydrofolate
-
-
-
-
?
ATP + formate + tetrahydropteroyl-(Glu)n
ADP + phosphate + 10-formyltetrahydropteroyl-(Glu)n
-
r, n: 3
-
?
ATP + formate + tetrahydropteroyl-(Glu)n
ADP + phosphate + 10-formyltetrahydropteroyl-(Glu)n
-
r, n: 2,3
-
?
ATP + formate + tetrahydropteroyl-(Glu)n
ADP + phosphate + 10-formyltetrahydropteroyl-(Glu)n
-
-
-
-
?
ATP + formate + tetrahydropteroyl-(Glu)n
ADP + phosphate + 10-formyltetrahydropteroyl-(Glu)n
-
n: 1-5
-
-
?
ATP + formate + tetrahydropteroyl-(Glu)n
ADP + phosphate + 10-formyltetrahydropteroyl-(Glu)n
-
n: 1-6
-
-
?
ATP + formate + tetrahydropteroyl-(Glu)n
ADP + phosphate + 10-formyltetrahydropteroyl-(Glu)n
-
-
-
-
?
ATP + formate + tetrahydropteroyl-(Glu)n
ADP + phosphate + 10-formyltetrahydropteroyl-(Glu)n
-
n: 1-5
-
-
?
Carbamoyl phosphate + ADP
? + ATP
-
-
-
?
Carbamoyl phosphate + ADP
? + ATP
-
-
-
?
tetrahydrofolate + formate + ATP
10-formyltetrahydrofolate + ADP + phosphate
-
monofunctional enzyme similar in structure to the cytoplasmatic trifunctional enzyme, dehydrogenase and cyclohydrolase activities are silent due to mutations of critical binding and catalytic residues
mitochondria also use formyltetrahydrofolate to produce formylmethionyl-tRNA to initiate protein synthesis
-
r
tetrahydrofolate + formate + ATP
10-formyltetrahydrofolate + ADP + phosphate
-
trifunctional enzyme exhibits synthetase, dehydrogenase and cyclohydrogenase activities
-
-
r
tetrahydrofolate + formate + ATP
10-formyltetrahydrofolate + ADP + phosphate
-
monofunctional enzyme
-
-
?
tetrahydrofolate + formate + ATP
10-formyltetrahydrofolate + ADP + phosphate
trifunctional enzyme exhibits synthetase, dehydrogenase and cyclohydrolase activities
-
-
r
additional information
?
-
-
enzyme is involved in the folate-mediated one-carbon metabolism, overview
-
-
?
additional information
?
-
the enzyme may participate in the progression of colorectal cancer by conferring growth advantage
-
-
?
additional information
?
-
-
the enzyme may participate in the progression of colorectal cancer by conferring growth advantage
-
-
?
additional information
?
-
(MTHFD1) is a trifunctional enzyme that interconverts tetrahydrofolate derivatives for nucleotide synthesis
-
-
?
additional information
?
-
MTHFD1L directly interacts with the c-MYC proto-oncogene and basic helix-loop-helix (bHLH) transcription factor. MTHFD1L directly interacts with the MAGE family member D1 (MAGED)
-
-
-
additional information
?
-
-
Leishmania possess a second cytoplasmic pathway for 10-formyltetrahydrofolate synthesis through FTL
-
-
?
additional information
?
-
-
MTHFD1 is a cytoplasmic enzyme with 5,10-methylenetetrahydrofolate dehydrogenase, 5,10-methenyltetrahydrofolate cyclohydrolase, and 10-formyltetrahydrofolate synthetase activities
-
-
?
additional information
?
-
the presence of cytoplasmic and mitochondrial isoforms of a trifunctional dehydrogenase-cyclohydrolase-synthetase support a model wherin the mitochondria can produce fromate which can be used by the cytoplasmic enzymes for the synthesis of purins and for methylation reactions
-
-
?
additional information
?
-
the presence of cytoplasmic and mitochondrial isoforms of a trifunctional dehydrogenase-cyclohydrolase-synthetase support a model wherin the mitochondria can produce fromate which can be used by the cytoplasmic enzymes for the synthesis of purins and for methylation reactions
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
ADP + phosphate + 10-formyltetrahydrofolate
?
ATP + formate + tetrahydrofolate
?
ATP + formate + tetrahydrofolate
ADP + phosphate + 10-formyltetrahydrofolate
formate + ATP + tetrahydrofolate
10-formyltetrahydrofolate + ADP + phosphate
synthetase activity of MTHFD1
-
-
?
tetrahydrofolate + formate + ATP
10-formyltetrahydrofolate + ADP + phosphate
additional information
?
-
ADP + phosphate + 10-formyltetrahydrofolate
?
Clostridium acidi-urici
-
ATP production. The relative concentration of formylated and unformylated folate coenzymes may be a significant regulatory parameter in the purine-fermenting Clostridia
-
-
?
ADP + phosphate + 10-formyltetrahydrofolate
?
-
ATP production. The relative concentration of formylated and unformylated folate coenzymes may be a significant regulatory parameter in the purine-fermenting Clostridia
-
-
?
ATP + formate + tetrahydrofolate
?
Clostridium acidi-urici
-
two different physiological roles: 1. Functions anabolically in most organisms to activate formate via the forward reaction, and brings it into the one-carbon metabolic pool as N10-formyltetrahydrofolate, 2. In purine-fermenting bacteria the enzyme probably functions catabolically in the terminal step of the purine degradative pathway. This reaction may be responsible for ATP production in these organisms
-
-
?
ATP + formate + tetrahydrofolate
?
Clostridium acidi-urici
-
the enzyme is responsible for the recruitment of single carbon units from the formate pool into a variety of folate-dependent biosynthetic pathways
-
-
?
ATP + formate + tetrahydrofolate
?
-
two different physiological roles: 1. Functions anabolically in most organisms to activate formate via the forward reaction, and brings it into the one-carbon metabolic pool as N10-formyltetrahydrofolate, 2. In purine-fermenting bacteria the enzyme probably functions catabolically in the terminal step of the purine degradative pathway. This reaction may be responsible for ATP production in these organisms
-
-
?
ATP + formate + tetrahydrofolate
?
-
two different physiological roles: 1. Functions anabolically in most organisms to activate formate via the forward reaction, and brings it into the one-carbon metabolic pool as N10-formyltetrahydrofolate, 2. In purine-fermenting bacteria the enzyme probably functions catabolically in the terminal step of the purine degradative pathway. This reaction may be responsible for ATP production in these organisms
-
-
?
ATP + formate + tetrahydrofolate
?
-
two different physiological roles: 1. Functions anabolically in most organisms to activate formate via the forward reaction, and brings it into the one-carbon metabolic pool as N10-formyltetrahydrofolate, 2. In purine-fermenting bacteria the enzyme probably functions catabolically in the terminal step of the purine degradative pathway. This reaction may be responsible for ATP production in these organisms
-
-
?
ATP + formate + tetrahydrofolate
?
-
two different physiological roles: 1. Functions anabolically in most organisms to activate formate via the forward reaction, and brings it into the one-carbon metabolic pool as N10-formyltetrahydrofolate, 2. In purine-fermenting bacteria the enzyme probably functions catabolically in the terminal step of the purine degradative pathway. This reaction may be responsible for ATP production in these organisms
-
-
?
ATP + formate + tetrahydrofolate
?
-
two different physiological roles: 1. Functions anabolically in most organisms to activate formate via the forward reaction, and brings it into the one-carbon metabolic pool as N10-formyltetrahydrofolate, 2. In purine-fermenting bacteria the enzyme probably functions catabolically in the terminal step of the purine degradative pathway. This reaction may be responsible for ATP production in these organisms
-
-
?
ATP + formate + tetrahydrofolate
?
-
two different physiological roles: 1. Functions anabolically in most organisms to activate formate via the forward reaction, and brings it into the one-carbon metabolic pool as N10-formyltetrahydrofolate, 2. In purine-fermenting bacteria the enzyme probably functions catabolically in the terminal step of the purine degradative pathway. This reaction may be responsible for ATP production in these organisms
-
-
?
ATP + formate + tetrahydrofolate
?
-
two different physiological roles: 1. Functions anabolically in most organisms to activate formate via the forward reaction, and brings it into the one-carbon metabolic pool as N10-formyltetrahydrofolate, 2. In purine-fermenting bacteria the enzyme probably functions catabolically in the terminal step of the purine degradative pathway. This reaction may be responsible for ATP production in these organisms
-
-
?
ATP + formate + tetrahydrofolate
?
-
two different physiological roles: 1. Functions anabolically in most organisms to activate formate via the forward reaction, and brings it into the one-carbon metabolic pool as N10-formyltetrahydrofolate, 2. In purine-fermenting bacteria the enzyme probably functions catabolically in the terminal step of the purine degradative pathway. This reaction may be responsible for ATP production in these organisms
-
-
?
ATP + formate + tetrahydrofolate
?
-
rate-determining step in the conversion of formate to Ser
-
-
?
ATP + formate + tetrahydrofolate
?
-
two different physiological roles: 1. Functions anabolically in most organisms to activate formate via the forward reaction, and brings it into the one-carbon metabolic pool as N10-formyltetrahydrofolate, 2. In purine-fermenting bacteria the enzyme probably functions catabolically in the terminal step of the purine degradative pathway. This reaction may be responsible for ATP production in these organisms
-
-
?
ATP + formate + tetrahydrofolate
?
-
the trifunctional enzyme is involved in the interconversion of one-carbon adducts of tetrahydrofolate
-
-
?
ATP + formate + tetrahydrofolate
?
Pigeon
-
two different physiological roles: 1. Functions anabolically in most organisms to activate formate via the forward reaction, and brings it into the one-carbon metabolic pool as N10-formyltetrahydrofolate, 2. In purine-fermenting bacteria the enzyme probably functions catabolically in the terminal step of the purine degradative pathway. This reaction may be responsible for ATP production in these organisms
-
-
?
ATP + formate + tetrahydrofolate
?
-
two different physiological roles: 1. Functions anabolically in most organisms to activate formate via the forward reaction, and brings it into the one-carbon metabolic pool as N10-formyltetrahydrofolate, 2. In purine-fermenting bacteria the enzyme probably functions catabolically in the terminal step of the purine degradative pathway. This reaction may be responsible for ATP production in these organisms
-
-
?
ATP + formate + tetrahydrofolate
?
-
two different physiological roles: 1. Functions anabolically in most organisms to activate formate via the forward reaction, and brings it into the one-carbon metabolic pool as N10-formyltetrahydrofolate, 2. In purine-fermenting bacteria the enzyme probably functions catabolically in the terminal step of the purine degradative pathway. This reaction may be responsible for ATP production in these organisms
-
-
?
ATP + formate + tetrahydrofolate
?
-
two different physiological roles: 1. Functions anabolically in most organisms to activate formate via the forward reaction, and brings it into the one-carbon metabolic pool as N10-formyltetrahydrofolate, 2. In purine-fermenting bacteria the enzyme probably functions catabolically in the terminal step of the purine degradative pathway. This reaction may be responsible for ATP production in these organisms
-
-
?
ATP + formate + tetrahydrofolate
?
-
two different physiological roles: 1. Functions anabolically in most organisms to activate formate via the forward reaction, and brings it into the one-carbon metabolic pool as N10-formyltetrahydrofolate, 2. In purine-fermenting bacteria the enzyme probably functions catabolically in the terminal step of the purine degradative pathway. This reaction may be responsible for ATP production in these organisms
-
-
?
ATP + formate + tetrahydrofolate
?
-
the trifunctional enzyme is involved in the interconversion of one-carbon adducts of tetrahydrofolate
-
-
?
ATP + formate + tetrahydrofolate
?
-
enzyme of one-carbon metabolism
-
-
?
ATP + formate + tetrahydrofolate
?
-
two different physiological roles: 1. Functions anabolically in most organisms to activate formate via the forward reaction, and brings it into the one-carbon metabolic pool as N10-formyltetrahydrofolate, 2. In purine-fermenting bacteria the enzyme probably functions catabolically in the terminal step of the purine degradative pathway. This reaction may be responsible for ATP production in these organisms
-
-
?
ATP + formate + tetrahydrofolate
?
-
the trifunctional enzyme is involved in the interconversion of one-carbon adducts of tetrahydrofolate
-
-
?
ATP + formate + tetrahydrofolate
?
-
two different physiological roles: 1. Functions anabolically in most organisms to activate formate via the forward reaction, and brings it into the one-carbon metabolic pool as N10-formyltetrahydrofolate, 2. In purine-fermenting bacteria the enzyme probably functions catabolically in the terminal step of the purine degradative pathway. This reaction may be responsible for ATP production in these organisms
-
-
?
ATP + formate + tetrahydrofolate
ADP + phosphate + 10-formyltetrahydrofolate
-
-
-
?
ATP + formate + tetrahydrofolate
ADP + phosphate + 10-formyltetrahydrofolate
-
-
-
?
ATP + formate + tetrahydrofolate
ADP + phosphate + 10-formyltetrahydrofolate
-
-
-
?
ATP + formate + tetrahydrofolate
ADP + phosphate + 10-formyltetrahydrofolate
-
-
-
?
ATP + formate + tetrahydrofolate
ADP + phosphate + 10-formyltetrahydrofolate
-
-
?
ATP + formate + tetrahydrofolate
ADP + phosphate + 10-formyltetrahydrofolate
-
-
-
?
ATP + formate + tetrahydrofolate
ADP + phosphate + 10-formyltetrahydrofolate
FtfL activity is required for methylotrophic growth
-
?
ATP + formate + tetrahydrofolate
ADP + phosphate + 10-formyltetrahydrofolate
FtfL activity is required for methylotrophic growth
-
?
ATP + formate + tetrahydrofolate
ADP + phosphate + 10-formyltetrahydrofolate
-
-
-
?
ATP + formate + tetrahydrofolate
ADP + phosphate + 10-formyltetrahydrofolate
-
-
?
ATP + formate + tetrahydrofolate
ADP + phosphate + 10-formyltetrahydrofolate
-
-
?
ATP + formate + tetrahydrofolate
ADP + phosphate + 10-formyltetrahydrofolate
-
-
-
?
ATP + formate + tetrahydrofolate
ADP + phosphate + 10-formyltetrahydrofolate
-
-
-
-
?
ATP + formate + tetrahydrofolate
ADP + phosphate + 10-formyltetrahydrofolate
flow of one-carbon units through cytoplasmic and mitochondrial folate pathways, overview
-
-
r
ATP + formate + tetrahydrofolate
ADP + phosphate + 10-formyltetrahydrofolate
-
-
-
?
ATP + formate + tetrahydrofolate
ADP + phosphate + 10-formyltetrahydrofolate
-
-
-
?
ATP + formate + tetrahydrofolate
ADP + phosphate + 10-formyltetrahydrofolate
-
-
-
?
ATP + formate + tetrahydrofolate
ADP + phosphate + 10-formyltetrahydrofolate
-
-
-
?
ATP + formate + tetrahydrofolate
ADP + phosphate + 10-formyltetrahydrofolate
A7BK03, A7BK04, A7BK05, A7BK06, A7BK07, A7BK08, A7BK09, A7BK10, A7BK11, A7BK12, A7BK13, A7BK14, A7BK15, A7BK16, A7BK17 -
-
-
?
tetrahydrofolate + formate + ATP
10-formyltetrahydrofolate + ADP + phosphate
-
monofunctional enzyme similar in structure to the cytoplasmatic trifunctional enzyme, dehydrogenase and cyclohydrolase activities are silent due to mutations of critical binding and catalytic residues
mitochondria also use formyltetrahydrofolate to produce formylmethionyl-tRNA to initiate protein synthesis
-
r
tetrahydrofolate + formate + ATP
10-formyltetrahydrofolate + ADP + phosphate
-
trifunctional enzyme exhibits synthetase, dehydrogenase and cyclohydrogenase activities
-
-
r
tetrahydrofolate + formate + ATP
10-formyltetrahydrofolate + ADP + phosphate
-
monofunctional enzyme
-
-
?
tetrahydrofolate + formate + ATP
10-formyltetrahydrofolate + ADP + phosphate
trifunctional enzyme exhibits synthetase, dehydrogenase and cyclohydrolase activities
-
-
r
additional information
?
-
-
enzyme is involved in the folate-mediated one-carbon metabolism, overview
-
-
?
additional information
?
-
the enzyme may participate in the progression of colorectal cancer by conferring growth advantage
-
-
?
additional information
?
-
-
the enzyme may participate in the progression of colorectal cancer by conferring growth advantage
-
-
?
additional information
?
-
(MTHFD1) is a trifunctional enzyme that interconverts tetrahydrofolate derivatives for nucleotide synthesis
-
-
?
additional information
?
-
MTHFD1L directly interacts with the c-MYC proto-oncogene and basic helix-loop-helix (bHLH) transcription factor. MTHFD1L directly interacts with the MAGE family member D1 (MAGED)
-
-
-
additional information
?
-
-
Leishmania possess a second cytoplasmic pathway for 10-formyltetrahydrofolate synthesis through FTL
-
-
?
additional information
?
-
the presence of cytoplasmic and mitochondrial isoforms of a trifunctional dehydrogenase-cyclohydrolase-synthetase support a model wherin the mitochondria can produce fromate which can be used by the cytoplasmic enzymes for the synthesis of purins and for methylation reactions
-
-
?
additional information
?
-
the presence of cytoplasmic and mitochondrial isoforms of a trifunctional dehydrogenase-cyclohydrolase-synthetase support a model wherin the mitochondria can produce fromate which can be used by the cytoplasmic enzymes for the synthesis of purins and for methylation reactions
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
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deletion of the MIS1 gene has little effect
DNA sequence determination and analysis
expressed in CHO cells and Escherichia coli
expressed in Escherichia coli
-
expressed in Escherichia coli strain Y1
expression in CHO cells and Saccharomyces cerevisiae
expression in Escherichia coli
expression in Escherichia coli BL21
expression in Escherichia coli, localization of the interdomain region of the trifunctional enzyme by site-directed mutagenesis
-
expression of the mitochondrial isozyme as maltose-binding protein fusion protein in Escherichia coli, overexpression in yeast
-
gene DKFZp586G1517, DNA and amino acid sequence determination and analysis, overexpression of mitochondrial enzyme in HEK-293 cells, unlabeled or FLAG-tagged, stimulates cell growth
gene fhs, recombinant expression of His6-tagged enzyme in Escherichia coli strain BL21(DE3)pLysS Rosetta
gene FTHFS, DNA and amino acid sequence determination and analysis, phylogenetic analysis, genetic clusters, overview. Cloning and expression in Escherichia coli
gene fths, DNA and amino acid sequence determination and analysis, quantitative expression analysis by real-time PCR, phylogenetic analysis, cloning and expression in Escherichia coli strain JM109
overexpression of FTL using the multicopy episomal vector pXNG4-FTL
-
the wild type and R653Q mutant pBKeDCS constructs are transformed into Escherichia coli BL21 DE3 to express the full-length protein
-
-
-
Clostridium acidi-urici
-
expressed in CHO cells and Escherichia coli
-
expressed in CHO cells and Escherichia coli
-
expression in Escherichia coli
-
expression in Escherichia coli
-
expression in Escherichia coli
gene FTHFS, DNA and amino acid sequence determination and analysis, phylogenetic analysis, genetic clusters, overview. Cloning and expression in Escherichia coli
-
gene FTHFS, DNA and amino acid sequence determination and analysis, phylogenetic analysis, genetic clusters, overview. Cloning and expression in Escherichia coli
-
gene FTHFS, DNA and amino acid sequence determination and analysis, phylogenetic analysis, genetic clusters, overview. Cloning and expression in Escherichia coli
-
gene FTHFS, DNA and amino acid sequence determination and analysis, phylogenetic analysis, genetic clusters, overview. Cloning and expression in Escherichia coli
-
gene FTHFS, DNA and amino acid sequence determination and analysis, phylogenetic analysis, genetic clusters, overview. Cloning and expression in Escherichia coli
-
gene FTHFS, DNA and amino acid sequence determination and analysis, phylogenetic analysis, genetic clusters, overview. Cloning and expression in Escherichia coli
gene FTHFS, DNA and amino acid sequence determination and analysis, phylogenetic analysis, genetic clusters, overview. Cloning and expression in Escherichia coli
-
gene FTHFS, DNA and amino acid sequence determination and analysis, phylogenetic analysis, genetic clusters, overview. Cloning and expression in Escherichia coli
-
gene FTHFS, DNA and amino acid sequence determination and analysis, phylogenetic analysis, genetic clusters, overview. Cloning and expression in Escherichia coli
-
gene fths, DNA and amino acid sequence determination and analysis, quantitative expression analysis by real-time PCR, phylogenetic analysis, cloning and expression in Escherichia coli strain JM109
-
gene fths, DNA and amino acid sequence determination and analysis, quantitative expression analysis by real-time PCR, phylogenetic analysis, cloning and expression in Escherichia coli strain JM109
-
gene fths, DNA and amino acid sequence determination and analysis, quantitative expression analysis by real-time PCR, phylogenetic analysis, cloning and expression in Escherichia coli strain JM109
-
gene fths, DNA and amino acid sequence determination and analysis, quantitative expression analysis by real-time PCR, phylogenetic analysis, cloning and expression in Escherichia coli strain JM109
-
gene fths, DNA and amino acid sequence determination and analysis, quantitative expression analysis by real-time PCR, phylogenetic analysis, cloning and expression in Escherichia coli strain JM109
-
gene fths, DNA and amino acid sequence determination and analysis, quantitative expression analysis by real-time PCR, phylogenetic analysis, cloning and expression in Escherichia coli strain JM109
-
gene fths, DNA and amino acid sequence determination and analysis, quantitative expression analysis by real-time PCR, phylogenetic analysis, cloning and expression in Escherichia coli strain JM109
-
gene fths, DNA and amino acid sequence determination and analysis, quantitative expression analysis by real-time PCR, phylogenetic analysis, cloning and expression in Escherichia coli strain JM109
-
gene fths, DNA and amino acid sequence determination and analysis, quantitative expression analysis by real-time PCR, phylogenetic analysis, cloning and expression in Escherichia coli strain JM109
gene fths, DNA and amino acid sequence determination and analysis, quantitative expression analysis by real-time PCR, phylogenetic analysis, cloning and expression in Escherichia coli strain JM109
gene fths, DNA and amino acid sequence determination and analysis, quantitative expression analysis by real-time PCR, phylogenetic analysis, cloning and expression in Escherichia coli strain JM109
gene fths, DNA and amino acid sequence determination and analysis, quantitative expression analysis by real-time PCR, phylogenetic analysis, cloning and expression in Escherichia coli strain JM109
gene fths, DNA and amino acid sequence determination and analysis, quantitative expression analysis by real-time PCR, phylogenetic analysis, cloning and expression in Escherichia coli strain JM109
gene fths, DNA and amino acid sequence determination and analysis, quantitative expression analysis by real-time PCR, phylogenetic analysis, cloning and expression in Escherichia coli strain JM109
-
gene fths, DNA and amino acid sequence determination and analysis, quantitative expression analysis by real-time PCR, phylogenetic analysis, cloning and expression in Escherichia coli strain JM109
-
gene fths, DNA and amino acid sequence determination and analysis, quantitative expression analysis by real-time PCR, phylogenetic analysis, cloning and expression in Escherichia coli strain JM109
gene fths, DNA and amino acid sequence determination and analysis, quantitative expression analysis by real-time PCR, phylogenetic analysis, cloning and expression in Escherichia coli strain JM109
gene fths, DNA and amino acid sequence determination and analysis, quantitative expression analysis by real-time PCR, phylogenetic analysis, cloning and expression in Escherichia coli strain JM109
gene fths, DNA and amino acid sequence determination and analysis, quantitative expression analysis by real-time PCR, phylogenetic analysis, cloning and expression in Escherichia coli strain JM109
gene fths, DNA and amino acid sequence determination and analysis, quantitative expression analysis by real-time PCR, phylogenetic analysis, cloning and expression in Escherichia coli strain JM109
gene fths, DNA and amino acid sequence determination and analysis, quantitative expression analysis by real-time PCR, phylogenetic analysis, cloning and expression in Escherichia coli strain JM109
gene fths, DNA and amino acid sequence determination and analysis, quantitative expression analysis by real-time PCR, phylogenetic analysis, cloning and expression in Escherichia coli strain JM109
gene fths, DNA and amino acid sequence determination and analysis, quantitative expression analysis by real-time PCR, phylogenetic analysis, cloning and expression in Escherichia coli strain JM109
gene fths, DNA and amino acid sequence determination and analysis, quantitative expression analysis by real-time PCR, phylogenetic analysis, cloning and expression in Escherichia coli strain JM109
gene fths, DNA and amino acid sequence determination and analysis, quantitative expression analysis by real-time PCR, phylogenetic analysis, cloning and expression in Escherichia coli strain JM109
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
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Lovell, C.R.; Przybyla, A.; Ljungdahl, L.G.
Cloning and expression in Escherichia coli of the Clostridium thermoaceticum gene encoding thermostable formyltetrahydrofolate synthetase
Arch. Microbiol.
149
280-285
1988
Moorella thermoacetica
brenda
Strong, W.; Joshi, G.; Lura, R.; Muthukumaraswamy, N.; Schirch, V.
10-Formyltetrahydrofolate synthetase. Evidence for a conformational change in the enzyme upon binding of tetrahydropteroylpolyglutamates
J. Biol. Chem.
262
12519-12525
1987
Oryctolagus cuniculus
brenda
Schegg, K.M.; Welch jr., W.
The effect of nordihydroguaiaretic acid and related lignans on formyltetrahydrofolate synthetase and carboxylesterase
Biochim. Biophys. Acta
788
167-180
1984
Bos taurus, Cavia porcellus, Homo sapiens, Mus musculus, Rattus norvegicus
brenda
Paukert, J.L.; Rabinowitz, J.C.
Formyl-methenyl-methylenetetrahydrofolate synthetase (combined): a multifunctional protein in eukaryotic folate metabolism
Methods Enzymol.
66
616-626
1980
Saccharomyces cerevisiae, Ovis aries, Sus scrofa
brenda
Buttlaire, D.H.
Purification and properties of formyltetrahydrofolate synthetase
Methods Enzymol.
66
585-599
1980
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Mus musculus (Q3V3R1), Mus musculus
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Impact of mutating the key residues of a bifunctional 5,10-methylenetetrahydrofolate dehydrogenase-cyclohydrolase from Escherichia coli on its activities
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Clostridium perfringens
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Homo sapiens (Q6UB35)
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