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Arthritis, Experimental
Acellular Fish Skin Grafts and Pig Urinary Bladder Matrix Assessed in the Collagen-Induced Arthritis Mouse Model.
Breast Neoplasms
Cyclopentenyl cytosine induces senescence in breast cancer cells through the nucleolar stress response and activation of p53.
Carcinoma
Enhancement of the toxicity and DNA incorporation of arabinosyl-5-azacytosine and 1-beta-D-arabinofuranosylcytosine by cyclopentenyl cytosine.
Carcinoma
IMPDH1/YB-1 Positive Feedback Loop Assembles Cytoophidia and Represents a Therapeutic Target in Metastatic Tumors.
Carcinoma, Ehrlich Tumor
CTP synthetase from Ehrlich ascites tumor cells. Subunit stoichiometry and regulation of activity.
Carcinoma, Ehrlich Tumor
Purification and properties of CTP synthetase from Ehrlich ascites tumor cells.
Carcinoma, Ehrlich Tumor
Role of GTP in CTP synthetase from Ehrlich ascites tumor cells.
Carcinoma, Ehrlich Tumor
Synthesis of N4-substituted CTP by mammalian CTP synthetase.
Carcinoma, Ehrlich Tumor
The effect of some platinum compounds on the activity of the CTP synthetase of Ehrlich ascites tumor cells: in vitro and in vivo studies.
Carcinoma, Hepatocellular
Biochemical pharmacology of acivicin in rat hepatoma cells.
Carcinoma, Hepatocellular
CTP synthase forms the cytoophidium in human hepatocellular carcinoma.
Carcinoma, Hepatocellular
Increased concentration of CTP synthetase in hepatoma 3924A: immunological evidence.
Carcinoma, Hepatocellular
Multi-enzyme-targeted chemotherapy by acivicin and actinomycin.
Carcinoma, Hepatocellular
Oncolytic activity and mechanism of action of a novel L-cysteine derivative, L-cysteine, ethyl ester, S-(N-methylcarbamate) monohydrochloride.
Carcinoma, Hepatocellular
Origin of increased deoxycytidine excretion into urine of rats bearing Yoshida ascites sarcoma.
Carcinoma, Hepatocellular
Potentiation of antimetabolite action by dibromodulcitol in cell culture.
Carcinoma, Hepatocellular
Rapid in vivo inactivation by acivicin of CTP synthetase, carbamoyl-phosphate synthetase II, and amidophosphoribosyltransferase in hepatoma.
Carcinoma, Hepatocellular
Uridine and cytidine nucleotide synthesis in renal hypertrophy: biochemical differences in response to the growth stimulus of diabetes and unilateral nephrectomy.
Carcinoma, Renal Cell
IMPDH1/YB-1 Positive Feedback Loop Assembles Cytoophidia and Represents a Therapeutic Target in Metastatic Tumors.
Carcinosarcoma
Origin of increased deoxycytidine excretion into urine of rats bearing Yoshida ascites sarcoma.
Cerebral Hemorrhage
Computed tomography perfusion in patients of stroke with left ventricular assist device.
Child Nutrition Disorders
Cash transfer programmes in lower-income and middle-income countries: understanding pathways to nutritional change-a realist review protocol.
Colorectal Neoplasms
Global metabolic reprogramming of colorectal cancer occurs at adenoma stage and is induced by MYC.
Colorectal Neoplasms
Low cytosine triphosphate synthase 2 expression renders resistance to 5-fluorouracil in colorectal cancer.
COVID-19
Targeting CTP Synthetase 1 to Restore Interferon Induction and Impede Nucleotide Synthesis in SARS-CoV-2 Infection.
ctp synthase (glutamine hydrolysing) deficiency
CTP synthase 1 deficiency in humans reveals its central role in lymphocyte proliferation.
ctp synthase (glutamine hydrolysing) deficiency
CTP Synthase 1 Deficiency in Successfully Transplanted Siblings with Combined Immune Deficiency and Chronic Active EBV Infection.
ctp synthase (glutamine hydrolysing) deficiency
Epstein-Barr Virus Induced Cytidine Metabolism Roles in Transformed B-Cell Growth and Survival.
ctp synthase (glutamine hydrolysing) deficiency
Failure of Viral-Specific T Cells Administered in Pre-transplant Settings in Children with Inborn Errors of Immunity.
ctp synthase (glutamine hydrolysing) deficiency
Impaired lymphocyte function and differentiation in CTPS1-deficient patients result from a hypomorphic homozygous mutation.
ctp synthase (glutamine hydrolysing) deficiency
Variable phenotype and discrete alterations of immune phenotypes in CTP synthase 1 deficiency: Report of 2 siblings.
Epstein-Barr Virus Infections
CTP Synthase 1 Deficiency in Successfully Transplanted Siblings with Combined Immune Deficiency and Chronic Active EBV Infection.
Hepatitis B
Another ten stories in antiviral drug discovery (part C): "Old" and "new" antivirals, strategies, and perspectives.
Herpes Simplex
Another ten stories in antiviral drug discovery (part C): "Old" and "new" antivirals, strategies, and perspectives.
HIV Infections
Another ten stories in antiviral drug discovery (part C): "Old" and "new" antivirals, strategies, and perspectives.
Hypersensitivity
DNA vaccination with the major outer-membrane protein gene induces acquired immunity to Chlamydia trachomatis (mouse pneumonitis) infection.
Infections
Another ten stories in antiviral drug discovery (part C): "Old" and "new" antivirals, strategies, and perspectives.
Infections
DNA vaccination with the major outer-membrane protein gene induces acquired immunity to Chlamydia trachomatis (mouse pneumonitis) infection.
Infections
Escherichia coli nucleoside diphosphate kinase interactions with T4 phage proteins of deoxyribonucleotide synthesis and possible regulatory functions.
Infections
Loss of RASGRP1 in humans impairs T-cell expansion leading to Epstein-Barr virus susceptibility.
Leukemia
Evidence for transformation-related increase in CTP synthetase activity in situ in human lymphoblastic leukemia.
Leukemia
Impaired lymphocyte function and differentiation in CTPS1-deficient patients result from a hypomorphic homozygous mutation.
Leukemia
Resistance to cytosine arabinoside in acute leukemia: the significance of mutations in CTP synthetase.
Leukemia
The IMP dehydrogenase inhibitor mycophenolic acid antagonizes the CTP synthetase inhibitor 3-deazauridine in MOLT-3 human leukemia cells: a central role for phosphoribosyl pyrophosphate.
Leukemia, Myeloid, Acute
Cyclopentenyl cytosine inhibits cytidine triphosphate synthetase in paediatric acute non-lymphocytic leukaemia: a promising target for chemotherapy.
Leukemia, T-Cell
Impaired lymphocyte function and differentiation in CTPS1-deficient patients result from a hypomorphic homozygous mutation.
Liver Failure
Safety of laparoscopic radical gastrectomy in gastric cancer patients with liver cirrhosis.
Lung Neoplasms
Protective Effect of Polysaccharides Extracted from Cudrania tricuspidata Fruit against Cisplatin-Induced Cytotoxicity in Macrophages and a Mouse Model.
Lupus Nephritis
A22: consensus treatment plans for induction therapy in childhood proliferative lupus nephritis-status of use in daily clinical care.
Lymphadenopathy
Features of Computed Tomography Perfusion of Mediastinal Lymphadenopathies: a Pathology-based Retrospective Study.
Lymphoma
Epstein-Barr Virus Induced Cytidine Metabolism Roles in Transformed B-Cell Growth and Survival.
Lymphoma
Impaired lymphocyte function and differentiation in CTPS1-deficient patients result from a hypomorphic homozygous mutation.
Lymphoproliferative Disorders
Cytidine triphosphate synthetase activity in lymphoproliferative disorders.
Malnutrition
Effects of unconditional cash transfers on the outcome of treatment for severe acute malnutrition (SAM): a cluster-randomised trial in the Democratic Republic of the Congo.
Malnutrition
Factors Associated With the Risk of Acute Malnutrition Among Children Aged 6 to 36 Months in Households Targeted by an Emergency Cash Transfer Program.
Melanoma
Circulating Tumor Cells, DNA, and mRNA: Potential for Clinical Utility in Patients With Melanoma.
Nasopharyngeal Carcinoma
[Cytidine triphosphate synthetase gene expressed in the homogenous nasopharyngeal carcinoma tissue cells]
Neoplasm Metastasis
Identification of critical genes associated with human osteosarcoma metastasis based on integrated gene expression profiling.
Neoplasms
Activities of various enzymes of pyrimidine nucleotide and DNA syntheses in normal and neoplastic human tissues.
Neoplasms
Ara-C metabolism: implications for drug resistance and drug interactions.
Neoplasms
Cancer targeting peptides.
Neoplasms
Comments on: cylopentenyl cytosine inhibits cytidine triphosphate synthetase in paediatric acute non-lymphocytic leukaemia: a promising target for chemotherapy. A.C. Verschuur et al. Eur J Cancer 2000, 36, 627-635.
Neoplasms
Consensus Treatment Plans for Chronic Nonbacterial Osteomyelitis Refractory to Nonsteroidal Anti-Inflammatory Drugs and/or with Active Spinal Lesions.
Neoplasms
CTP synthase forms the cytoophidium in human hepatocellular carcinoma.
Neoplasms
CTP synthetase from Ehrlich ascites tumor cells. Subunit stoichiometry and regulation of activity.
Neoplasms
CTPS and IMPDH form cytoophidia in developmental thymocytes.
Neoplasms
Cyclopentenyl cytosine (CPEC): an overview of its in vitro and in vivo activity.
Neoplasms
Cyclopentenyl cytosine inhibits cytidine triphosphate synthetase in paediatric acute non-lymphocytic leukaemia: a promising target for chemotherapy.
Neoplasms
Discretization of Gene Expression Data Unmasks Molecular Subgroups Recurring in Different Human Cancer Types.
Neoplasms
Ectopic miR-975 induces CTP synthase directed cell proliferation and differentiation in Drosophila melanogaster.
Neoplasms
Glutamine deprivation initiates reversible assembly of mammalian rods and rings.
Neoplasms
Histidine-Dependent Protein Methylation Is Required for Compartmentalization of CTP Synthase.
Neoplasms
Identification of a Gene Encoding Slow Skeletal Muscle Troponin T as a Novel Marker for Immortalization of Retinal Pigment Epithelial Cells.
Neoplasms
Increased CTP synthetase activity in cancer cells.
Neoplasms
Increased cytidine 5'-triphosphate synthetase activity in rat and human tumors.
Neoplasms
Low cytosine triphosphate synthase 2 expression renders resistance to 5-fluorouracil in colorectal cancer.
Neoplasms
MEASURE: Multisite studies for validation and improvement of a highly efficient culture (HEC) assay for detection of undifferentiated human pluripotent stem cells intermingled in cell therapy products.
Neoplasms
Molecular cloning of the human CTP synthetase gene by functional complementation with purified human metaphase chromosomes.
Neoplasms
No Detection of Pseudocapsule of Tumor-Parenchyma Interface on Multidetector Computed Tomography (MDCT) Images: Clinical Significance and Histological Reflections in Renal Cell Carcinoma.
Neoplasms
Oncolytic activity and mechanism of action of a novel L-cysteine derivative, L-cysteine, ethyl ester, S-(N-methylcarbamate) monohydrochloride.
Neoplasms
Penetration of 3-deazauridine into human brain, intracerebral tumor, and cerebrospinal fluid.
Neoplasms
Purification and properties of CTP synthetase from Ehrlich ascites tumor cells.
Neoplasms
Role of antimetabolites of purine and pyrimidine nucleotide metabolism in tumor cell differentiation.
Neoplasms
Role of GTP in CTP synthetase from Ehrlich ascites tumor cells.
Neoplasms
SNAP29 mediates the assembly of histidine-induced CTP synthase filaments in proximity to the cytokeratin network.
Neoplasms
Structure of the synthetase domain of human CTP synthetase, a target for anticancer therapy.
Neoplasms
Synthesis of N4-substituted CTP by mammalian CTP synthetase.
Neoplasms
The effect of some platinum compounds on the activity of the CTP synthetase of Ehrlich ascites tumor cells: in vitro and in vivo studies.
Neoplasms
Uridine and cytidine nucleotide synthesis in renal hypertrophy: biochemical differences in response to the growth stimulus of diabetes and unilateral nephrectomy.
Neuroblastoma
Cyclopentenyl cytosine-induced activation of deoxycytidine kinase increases gemcitabine anabolism and cytotoxicity in neuroblastoma.
Neuroblastoma
Retinoic acid reduces the cytotoxicity of cyclopentenyl cytosine in neuroblastoma cells.
Osteosarcoma
Identification of critical genes associated with human osteosarcoma metastasis based on integrated gene expression profiling.
Pancreatic Neoplasms
MUC1 and HIF-1alpha Signaling Crosstalk Induces Anabolic Glucose Metabolism to Impart Gemcitabine Resistance to Pancreatic Cancer.
Periodontal Diseases
Label-free quantitative proteomic analysis of human periodontal ligament stem cells by high-resolution mass spectrometry.
Poxviridae Infections
Therapy and short-term prophylaxis of poxvirus infections: historical background and perspectives.
Pre-Eclampsia
Energy deficiency caused by CTPS downregulation in decidua may contribute to pre-eclampsia by impairing decidualization.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Determination of CTP synthetase activity in crude cell homogenates by a fast and sensitive non-radiochemical assay using anion-exchange high-performance liquid chromatography.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Evidence for transformation-related increase in CTP synthetase activity in situ in human lymphoblastic leukemia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Increased activity of cytidine Triphosphate synthetase in pediatric acute lymphoblastic leukemia.
Primary Immunodeficiency Diseases
The Challenge of Next Generation Sequencing in a Boy With Severe Mononucleosis and EBV-related Lymphoma.
Rothmund-Thomson Syndrome
Failure of Viral-Specific T Cells Administered in Pre-transplant Settings in Children with Inborn Errors of Immunity.
Scleroderma, Localized
A retrospective study: Impact of consensus treatment plans on systemic therapy of pediatric morphea.
Severe Acute Malnutrition
Effects of unconditional cash transfers on the outcome of treatment for severe acute malnutrition (SAM): a cluster-randomised trial in the Democratic Republic of the Congo.
Severe Combined Immunodeficiency
Failure of Viral-Specific T Cells Administered in Pre-transplant Settings in Children with Inborn Errors of Immunity.
Smallpox
Therapy and short-term prophylaxis of poxvirus infections: historical background and perspectives.
Starvation
Histidine-Dependent Protein Methylation Is Required for Compartmentalization of CTP Synthase.
Starvation
Ubiquitination and filamentous structure of cytidine triphosphate synthase.
Stomach Neoplasms
Safety of laparoscopic radical gastrectomy in gastric cancer patients with liver cirrhosis.
Stomach Neoplasms
[Effects of Toosendanin on the formation of CTPS cytoophidium in human gastric cancer cell MKN-45 and its mechanism].
Trypanosomiasis, African
Activation and inhibition of CTP synthase from Trypanosoma brucei, the causative agent of African sleeping sickness.
Trypanosomiasis, African
Expression, purification, characterization, and in vivo targeting of trypanosome CTP synthetase for treatment of African sleeping sickness.
Trypanosomiasis, African
Synthesis and Biological Evaluation of CTP Synthetase Inhibitors as Potential Agents for the Treatment of African Trypanosomiasis.
Trypanosomiasis, African
Trypanosoma brucei CTP synthetase: a target for the treatment of African sleeping sickness.
Tuberculosis
A Phenotypic Based Target Screening Approach Delivers New Antitubercular CTP Synthetase Inhibitors.
Tuberculosis
Thiophenecarboxamide Derivatives Activated by EthA Kill Mycobacterium tuberculosis by Inhibiting the CTP Synthetase PyrG.
Vascular System Injuries
Smooth muscle-specific drug targets for next-generation drug-eluting stent.
Wiskott-Aldrich Syndrome
Failure of Viral-Specific T Cells Administered in Pre-transplant Settings in Children with Inborn Errors of Immunity.
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Verschuur, A.C.; van Gennip, A.H.; Muller, E.J.; Voute, P.A.; Vreken, P.; Van Kuilenburg, A.B.
Cytidine triphosphate synthase activity and mRNA expression in normal human blood cells
Biol. Chem.
380
41-46
1999
Homo sapiens
brenda
van Kuilenburg, A.B.; Meinsma, R.; Vreken, P.; Waterham, H.R.; van Gennip, A.H.
Identification of a cDNA encoding an isoform of human CTP synthetase
Biochim. Biophys. Acta
1492
548-552
2000
Escherichia coli (P0A7E5), Escherichia coli, Homo sapiens (P17812), Homo sapiens (Q9NRF8), Homo sapiens, Saccharomyces cerevisiae (P28274), Saccharomyces cerevisiae (P38627), Mus musculus (P70303), Mus musculus (P70698)
brenda
Verschuur, A.C.; Van Gennip, A.H.; Leen, R.; Meinsma, R.; Voute, P.A.; van Kuilenburg, A.B.
In vitro inhibition of cytidine triphosphate synthetase activity by cyclopentenyl cytosine in paediatric acute lymphocytic leukaemia
Br. J. Haematol.
110
161-169
2000
Homo sapiens
brenda
van Kuilenburg, A.B.P.; Elzinga, L.; Van Gennip, A.H.
Kinetic properties of CTP synthetase from HL-60 cells
Adv. Exp. Med. Biol.
431
255-258
1998
Homo sapiens
brenda
van Kuilenburg, A.B.P.; Meinsma, R.; Vreken, P.; Waterham, H.R.; van Gennip, A.H.
Isoforms of human CTP synthetase
Adv. Exp. Med. Biol.
486
257-261
2000
Homo sapiens
brenda
Kursula, P.; Flodin, S.; Ehn, M.; Hammarstroem, M.; Schueler, H.; Nordlund, P.; Stenmark, P.
Structure of the synthetase domain of human CTP synthetase, a target for anticancer therapy
Acta Crystallogr. Sect. F
62
613-617
2006
Homo sapiens
brenda
Chang, Y.F.; Martin, S.S.; Baldwin, E.P.; Carman, G.M.
Phosphorylation of human CTP synthetase 1 by protein kinase C: identification of Ser(462) and Thr(455) as major sites of phosphorylation
J. Biol. Chem.
282
17613-17622
2007
Homo sapiens
brenda
Higgins, M.J.; Graves, P.R.; Graves, L.M.
Regulation of human cytidine triphosphate synthetase 1 by glycogen synthase kinase 3
J. Biol. Chem.
282
29493-29503
2007
Homo sapiens (Q9NRF8), Homo sapiens
brenda
Choi, M.G.; Carman, G.M.
Phosphorylation of human CTP synthetase 1 by protein kinase A: identification of Thr455 as a major site of phosphorylation
J. Biol. Chem.
282
5367-5377
2007
Homo sapiens
brenda
Higgins, M.J.; Loiselle, D.; Haystead, T.A.; Graves, L.M.
Human cytidine triphosphate synthetase 1 interacting proteins
Nucleosides Nucleotides Nucleic Acids
27
850-857
2008
Homo sapiens
brenda
Chang, Y.F.; Carman, G.M.
CTP synthetase and its role in phospholipid synthesis in the yeast Saccharomyces cerevisiae
Prog. Lipid Res.
47
333-339
2008
Saccharomyces cerevisiae, Homo sapiens
brenda
Kassel, K.M.; Au, d.a..R.; Higgins, M.J.; Hines, M.; Graves, L.M.
Regulation of human cytidine triphosphate synthetase 2 by phosphorylation
J. Biol. Chem.
285
33727-33736
2010
Homo sapiens, Homo sapiens (Q9NRF8)
brenda
Gou, K.M.; Chang, C.C.; Shen, Q.J.; Sung, L.Y.; Liu, J.L.
CTP synthase forms cytoophidia in the cytoplasm and nucleus
Exp. Cell Res.
323
242-253
2014
Homo sapiens, Mus musculus
brenda
Chang, C.C.; Jeng, Y.M.; Peng, M.; Keppeke, G.D.; Sung, L.Y.; Liu, J.L.
CTP synthase forms the cytoophidium in human hepatocellular carcinoma
Exp. Cell Res.
361
292-299
2017
Homo sapiens, Drosophila melanogaster (X2JCY2)
brenda