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EC Tree
IUBMB CommentsNot identical with EC 6.3.4.3 (formate---tetrahydrofolate ligase).
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Synonyms
Dihydrofolate formyltransferase, Formyl dihydrofolate synthase, Formyltransferase, dihydrofolate,
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Dihydrofolate formyltransferase
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Formyl dihydrofolate synthase
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Formyltransferase, dihydrofolate
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ATP + formate + dihydrofolate = ADP + phosphate + 10-formyldihydrofolate
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formate:dihydrofolate ligase (ADP-forming)
Not identical with EC 6.3.4.3 (formate---tetrahydrofolate ligase).
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ATP + formate + dihydrofolate
ADP + phosphate + 10-formyldihydrofolate
ATP + formate + dihydrofolate
ADP + phosphate + 10-formyldihydrofolate
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ATP + formate + dihydrofolate
ADP + phosphate + 10-formyldihydrofolate
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K+
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enhances activity
Mg2+
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required
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0.097 - 0.911
dihydrofolate
0.097
dihydrofolate
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8.5
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brenda
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brenda
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MCF-7
brenda
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brenda
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100
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60 s, denaturation
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Perchloric acid, 5%, denatures
Perchloric acid, 5%, denatures
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Perchloric acid, 5%, denatures
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Drake, J.C.; Baram, J.; Allegra, C.J.
Isolation and characterization of a novel dihydrofolate formylating enzyme from human MCF-7 breast cancer cells
Biochem. Pharmacol.
39
615-618
1990
Homo sapiens, Lacticaseibacillus casei
brenda
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6.3.4.17 formate-dihydrofolate ligase
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