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carbamate kinase-like carbamoyl phosphate synthetase
this enzyme is a intermediary form between carbamate kinase and carbamoyl phosphate synthetase
carbamate kinase-like carbamoyl-phosphate synthetase
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carbamoyl phosphate synthase-1
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carbamoyl phosphate synthetase
carbamoyl phosphate synthetase 1
carbamoyl phosphate synthetase I
carbamoyl phosphate synthetase-1
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carbamoyl-phosphate synthetase
carbamoyl-phosphate synthetase 1
Carbamoyl-phosphate synthetase I
Carbamoylphosphate synthase
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Carbamoylphosphate synthase (ammonia)
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Carbamoylphosphate synthetase
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Carbamoylphosphate synthetase (ammonia)
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Carbamoylphosphate synthetase I
carbamoylphosphate synthetase-I
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Carbamyl phosphate synthase I
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carbamyl phosphate synthetase I
carbamyl-phosphate synthetase I
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Carbamylphosphate synthetase
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carbamylphosphate synthetase 1
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Carbamylphosphate synthetase I
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carbmoylphosphate synthetase
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Carbon-dioxide-ammonia ligase
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Carbonate kinase (phosphorylating)
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CPS I-like (ammonia- and N-acetyl-L-glutamate-dependent)
EC 2.7.2.5
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formerly
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mitochondrial carbamoylphosphate synthetase I
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carbamoyl phosphate synthetase
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carbamoyl phosphate synthetase
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carbamoyl phosphate synthetase
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carbamoyl phosphate synthetase
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carbamoyl phosphate synthetase 1
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carbamoyl phosphate synthetase 1
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carbamoyl phosphate synthetase 1
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carbamoyl phosphate synthetase 1
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carbamoyl phosphate synthetase 1
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carbamoyl phosphate synthetase I
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carbamoyl phosphate synthetase I
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carbamoyl phosphate synthetase I
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carbamoyl phosphate synthetase I
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carbamoyl phosphate synthetase I
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carbamoyl phosphate synthetase I
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carbamoyl-phosphate synthetase
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carbamoyl-phosphate synthetase
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carbamoyl-phosphate synthetase 1
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carbamoyl-phosphate synthetase 1
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carbamoyl-phosphate synthetase 1
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Carbamoyl-phosphate synthetase I
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Carbamoyl-phosphate synthetase I
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Carbamoylphosphate synthetase I
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Carbamoylphosphate synthetase I
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carbamyl phosphate synthetase I
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carbamyl phosphate synthetase I
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CPS
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CPS I-like (ammonia- and N-acetyl-L-glutamate-dependent)
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CPS I-like (ammonia- and N-acetyl-L-glutamate-dependent)
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CPS1
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CPSI
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Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
2 ATP + NH3 + hydrogencarbonate = 2 ADP + phosphate + carbamoyl phosphate
ATP + carbamate = ADP + carbamoyl phosphate
(1c)
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ATP + hydrogencarbonate = ADP + carboxyphosphate
(1a)
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NH3 + carboxyphosphate = carbamate + phosphate
(1b)
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2 ATP + NH3 + hydrogencarbonate = 2 ADP + phosphate + carbamoyl phosphate
depending on their physiological role, carbonyl phosphate synthetases use either glutamine or free ammonia as the nitrogen donor for carbamoyl phosphate synthesis, all enzymes contain the structurally equivalent of a triad-type glutamine amidotransferase, GAT, domain
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2 ATP + NH3 + hydrogencarbonate = 2 ADP + phosphate + carbamoyl phosphate
depending on their physiological role, carbonyl phosphate synthetases uses either glutamine or free ammonia as the nitrogen donor for carbamoyl phosphate synthesis, all enzymes contain the structurell equivalent of a triad-type glutamine amidotransferase, GAT, domain
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2 ATP + NH3 + hydrogencarbonate = 2 ADP + phosphate + carbamoyl phosphate
depending on their physiological role, carbonyl phosphate synthetasese uses either glutamine or free ammonia as the nitrogen donor for carbamoyl phosphate synthesis, all enzymes contain the structurell equivalent of a triad-type glutamine amidotransferase, GAT, domain
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2 ATP + NH3 + hydrogencarbonate = 2 ADP + phosphate + carbamoyl phosphate
non-glutamine-utilizing enzymes, lacking the catalytic cysteine residue, can generate carbamoyl phosphate only in presence of free ammonia
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2 ATP + NH3 + hydrogencarbonate = 2 ADP + phosphate + carbamoyl phosphate
the enzyme is enzymologically and structurally a carbamate kinase, stoichiometry
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2 ATP + NH3 + hydrogencarbonate = 2 ADP + phosphate + carbamoyl phosphate
the enzyme structure is ill-suited for catalysing the characteristic three-step reaction of carbamoyl-phosphate synthetase and supports the view that the carbamate kinase-like carbamoyl-phosphate synthetase is in fact a highly thermostable and very slow carbamate kinase that, in extreme environment of Pyrococcus furiosus, may have the new function of making, rather than using, carbamoyl phosphate
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2 ATP + NH3 + hydrogencarbonate = 2 ADP + phosphate + carbamoyl phosphate
overall reaction
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Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
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2 ATP + L-Gln + HCO3-
2 ADP + phosphate + L-Glu + carbamoyl phosphate
2 ATP + NH3 + CO2 + H2O
2 ADP + phosphate + carbamoyl phosphate
2 ATP + NH3 + CO2 + H2O
?
2 ATP + NH4+ + HCO3-
2 ADP + phosphate + carbamoyl phosphate
ATP + carbamate
ADP + carbamoyl phosphate
ATP + NH3 + CO2 + H2O
ADP + phosphate + carbamoyl phosphate
ATP + NH3 + CO2 + H2O
ADP + phosphate + carbamoylphosphate
ATP + NH4+ + CO2 + H2O
ADP + phosphate + carbamoyl phosphate
ATP + NH4+ + CO2 + H2O
ADP + phosphate + carbamoylphosphate
ATP + NH4+ + HCO3- + H2O
ADP + phosphate + carbamoyl phosphate
additional information
?
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2 ATP + L-Gln + HCO3-
2 ADP + phosphate + L-Glu + carbamoyl phosphate
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-
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?
2 ATP + L-Gln + HCO3-
2 ADP + phosphate + L-Glu + carbamoyl phosphate
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-
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?
2 ATP + NH3 + CO2 + H2O
2 ADP + phosphate + carbamoyl phosphate
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-
-
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?
2 ATP + NH3 + CO2 + H2O
2 ADP + phosphate + carbamoyl phosphate
-
-
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?
2 ATP + NH3 + CO2 + H2O
2 ADP + phosphate + carbamoyl phosphate
-
-
-
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?
2 ATP + NH3 + CO2 + H2O
2 ADP + phosphate + carbamoyl phosphate
-
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-
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?
2 ATP + NH3 + CO2 + H2O
2 ADP + phosphate + carbamoyl phosphate
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-
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?
2 ATP + NH3 + CO2 + H2O
2 ADP + phosphate + carbamoyl phosphate
-
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-
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?
2 ATP + NH3 + CO2 + H2O
?
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plays a key role in the regulation of the urea cycle
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?
2 ATP + NH3 + CO2 + H2O
?
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primary ammonia-detoxifying enzyme
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?
2 ATP + NH3 + CO2 + H2O
?
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enzyme is involved in arginine and urea synthesis
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?
2 ATP + NH3 + CO2 + H2O
?
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primary ammonia-detoxifying enzyme
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?
2 ATP + NH3 + CO2 + H2O
?
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?
2 ATP + NH3 + CO2 + H2O
?
-
first enzyme involved in the biosynthesis of urea in the liver ureotelic animals
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?
2 ATP + NH3 + CO2 + H2O
?
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enzyme of urea cycle
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?
2 ATP + NH4+ + HCO3-
2 ADP + phosphate + carbamoyl phosphate
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?
2 ATP + NH4+ + HCO3-
2 ADP + phosphate + carbamoyl phosphate
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-
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?
2 ATP + NH4+ + HCO3-
2 ADP + phosphate + carbamoyl phosphate
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?
2 ATP + NH4+ + HCO3-
2 ADP + phosphate + carbamoyl phosphate
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ATP in form of MgATP2-
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?
2 ATP + NH4+ + HCO3-
2 ADP + phosphate + carbamoyl phosphate
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ATP in form of CoATP2-
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?
2 ATP + NH4+ + HCO3-
2 ADP + phosphate + carbamoyl phosphate
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-
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?
2 ATP + NH4+ + HCO3-
2 ADP + phosphate + carbamoyl phosphate
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?
2 ATP + NH4+ + HCO3-
2 ADP + phosphate + carbamoyl phosphate
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?
2 ATP + NH4+ + HCO3-
2 ADP + phosphate + carbamoyl phosphate
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?
2 ATP + NH4+ + HCO3-
2 ADP + phosphate + carbamoyl phosphate
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ATP in form of MgATP2-
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?
2 ATP + NH4+ + HCO3-
2 ADP + phosphate + carbamoyl phosphate
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?
2 ATP + NH4+ + HCO3-
2 ADP + phosphate + carbamoyl phosphate
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?
2 ATP + NH4+ + HCO3-
2 ADP + phosphate + carbamoyl phosphate
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ATP in form of MnATP2-
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?
2 ATP + NH4+ + HCO3-
2 ADP + phosphate + carbamoyl phosphate
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ATP in form of MgATP2-
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?
2 ATP + NH4+ + HCO3-
2 ADP + phosphate + carbamoyl phosphate
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ATP in form of CoATP2-
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?
2 ATP + NH4+ + HCO3-
2 ADP + phosphate + carbamoyl phosphate
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-
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?
2 ATP + NH4+ + HCO3-
2 ADP + phosphate + carbamoyl phosphate
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?
ATP + carbamate
ADP + carbamoyl phosphate
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r
ATP + carbamate
ADP + carbamoyl phosphate
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r
ATP + carbamate
ADP + carbamoyl phosphate
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r
ATP + NH3 + CO2 + H2O
ADP + phosphate + carbamoyl phosphate
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first step of the both the urea cycle and pyrimidine nucleotide biosynthesis patways
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?
ATP + NH3 + CO2 + H2O
ADP + phosphate + carbamoyl phosphate
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ir
ATP + NH3 + CO2 + H2O
ADP + phosphate + carbamoyl phosphate
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ir
ATP + NH3 + CO2 + H2O
ADP + phosphate + carbamoyl phosphate
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?
ATP + NH3 + CO2 + H2O
ADP + phosphate + carbamoyl phosphate
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?
ATP + NH3 + CO2 + H2O
ADP + phosphate + carbamoyl phosphate
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?
ATP + NH3 + CO2 + H2O
ADP + phosphate + carbamoyl phosphate
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the enzyme T1405N genotype influences nitric oxide production as well as vascular smooth muscle reactivity
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?
ATP + NH3 + CO2 + H2O
ADP + phosphate + carbamoyl phosphate
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CPS1 is a rate-limiting enzyme in the urea cycle
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?
ATP + NH3 + CO2 + H2O
ADP + phosphate + carbamoyl phosphate
three step reaction
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ir
ATP + NH3 + CO2 + H2O
ADP + phosphate + carbamoyl phosphate
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-
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ir
ATP + NH3 + CO2 + H2O
ADP + phosphate + carbamoyl phosphate
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three step reaction
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ir
ATP + NH3 + CO2 + H2O
ADP + phosphate + carbamoyl phosphate
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-
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?
ATP + NH3 + CO2 + H2O
ADP + phosphate + carbamoyl phosphate
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the first and rate-limiting step of the urea synthesis
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?
ATP + NH3 + CO2 + H2O
ADP + phosphate + carbamoyl phosphate
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?
ATP + NH3 + CO2 + H2O
ADP + phosphate + carbamoyl phosphate
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-
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?
ATP + NH3 + CO2 + H2O
ADP + phosphate + carbamoyl phosphate
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enzyme of the urea cycle
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?
ATP + NH3 + CO2 + H2O
ADP + phosphate + carbamoyl phosphate
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CPS is the rate-determining enzyme of the urea cycle and catalyzes the conversion of ammonia and bicarbonate to carbamoylphosphate in the periportal and intermediate zones of a liver lobule, overview. The enzyme is responsible for ammonia elimination
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?
ATP + NH3 + CO2 + H2O
ADP + phosphate + carbamoylphosphate
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?
ATP + NH3 + CO2 + H2O
ADP + phosphate + carbamoylphosphate
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the product carbamoyl phosphate is used in the biosynthesis of pyrimidines, arginine, and urea
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ir
ATP + NH3 + CO2 + H2O
ADP + phosphate + carbamoylphosphate
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the product carbamoylphosphate is used in the biosynethsis of pyrimidines, arginine, and urea
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ir
ATP + NH4+ + CO2 + H2O
ADP + phosphate + carbamoyl phosphate
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?
ATP + NH4+ + CO2 + H2O
ADP + phosphate + carbamoyl phosphate
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?
ATP + NH4+ + CO2 + H2O
ADP + phosphate + carbamoylphosphate
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?
ATP + NH4+ + CO2 + H2O
ADP + phosphate + carbamoylphosphate
Frog
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?
ATP + NH4+ + CO2 + H2O
ADP + phosphate + carbamoylphosphate
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?
ATP + NH4+ + CO2 + H2O
ADP + phosphate + carbamoylphosphate
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-
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?
ATP + NH4+ + CO2 + H2O
ADP + phosphate + carbamoylphosphate
-
-
-
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?
ATP + NH4+ + CO2 + H2O
ADP + phosphate + carbamoylphosphate
-
no activity with Gln
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?
ATP + NH4+ + CO2 + H2O
ADP + phosphate + carbamoylphosphate
-
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?
ATP + NH4+ + CO2 + H2O
ADP + phosphate + carbamoylphosphate
-
-
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?
ATP + NH4+ + CO2 + H2O
ADP + phosphate + carbamoylphosphate
-
-
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?
ATP + NH4+ + CO2 + H2O
ADP + phosphate + carbamoylphosphate
-
-
-
?
ATP + NH4+ + CO2 + H2O
ADP + phosphate + carbamoylphosphate
-
no activity with Gln
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?
ATP + NH4+ + CO2 + H2O
ADP + phosphate + carbamoylphosphate
-
-
-
?
ATP + NH4+ + CO2 + H2O
ADP + phosphate + carbamoylphosphate
-
no activity with Gln
-
?
ATP + NH4+ + CO2 + H2O
ADP + phosphate + carbamoylphosphate
-
-
-
?
ATP + NH4+ + CO2 + H2O
ADP + phosphate + carbamoylphosphate
-
-
-
?
ATP + NH4+ + CO2 + H2O
ADP + phosphate + carbamoylphosphate
-
-
-
?
ATP + NH4+ + CO2 + H2O
ADP + phosphate + carbamoylphosphate
-
-
-
?
ATP + NH4+ + CO2 + H2O
ADP + phosphate + carbamoylphosphate
-
-
-
?
ATP + NH4+ + CO2 + H2O
ADP + phosphate + carbamoylphosphate
-
-
-
?
ATP + NH4+ + CO2 + H2O
ADP + phosphate + carbamoylphosphate
-
-
-
?
ATP + NH4+ + CO2 + H2O
ADP + phosphate + carbamoylphosphate
-
-
-
?
ATP + NH4+ + CO2 + H2O
ADP + phosphate + carbamoylphosphate
-
-
-
?
ATP + NH4+ + CO2 + H2O
ADP + phosphate + carbamoylphosphate
-
-
-
?
ATP + NH4+ + CO2 + H2O
ADP + phosphate + carbamoylphosphate
-
-
-
?
ATP + NH4+ + CO2 + H2O
ADP + phosphate + carbamoylphosphate
-
-
-
?
ATP + NH4+ + CO2 + H2O
ADP + phosphate + carbamoylphosphate
-
-
-
?
ATP + NH4+ + CO2 + H2O
ADP + phosphate + carbamoylphosphate
-
-
-
?
ATP + NH4+ + CO2 + H2O
ADP + phosphate + carbamoylphosphate
-
-
-
?
ATP + NH4+ + CO2 + H2O
ADP + phosphate + carbamoylphosphate
-
-
-
?
ATP + NH4+ + CO2 + H2O
ADP + phosphate + carbamoylphosphate
-
-
-
?
ATP + NH4+ + CO2 + H2O
ADP + phosphate + carbamoylphosphate
-
-
-
?
ATP + NH4+ + CO2 + H2O
ADP + phosphate + carbamoylphosphate
-
-
-
?
ATP + NH4+ + CO2 + H2O
ADP + phosphate + carbamoylphosphate
-
-
-
?
ATP + NH4+ + CO2 + H2O
ADP + phosphate + carbamoylphosphate
-
-
-
?
ATP + NH4+ + CO2 + H2O
ADP + phosphate + carbamoylphosphate
-
-
-
-
?
ATP + NH4+ + CO2 + H2O
ADP + phosphate + carbamoylphosphate
-
no activity with Gln
-
?
ATP + NH4+ + CO2 + H2O
ADP + phosphate + carbamoylphosphate
-
-
-
?
ATP + NH4+ + HCO3- + H2O
ADP + phosphate + carbamoyl phosphate
-
-
-
?
ATP + NH4+ + HCO3- + H2O
ADP + phosphate + carbamoyl phosphate
-
-
-
-
?
ATP + NH4+ + HCO3- + H2O
ADP + phosphate + carbamoyl phosphate
the human enzyme removes excess, potentially neurotoxic ammonia via the urea cycle in a tightly regulated manner that avoids depletion of the ammonia pool, and shows inability to use glutamine as an alternative nitrogen donor
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?
ATP + NH4+ + HCO3- + H2O
ADP + phosphate + carbamoyl phosphate
synthesis of carbamoyl phosphate requires coordination of two hCPS active sites with ATP cleavage occurring at duplicated ATP grasp domains B and C
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?
ATP + NH4+ + HCO3- + H2O
ADP + phosphate + carbamoyl phosphate
-
-
-
?
additional information
?
-
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Rana cancrivora up-regulates hepatic carbamoyl phosphate synthetase I activity and tissue osmolyte levels in response to increased salinity
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?
additional information
?
-
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polymorphism of carbamyl phosphate synthetase I, certain carbamyl phosphate synthetase I alleles are associated with clinical outcome
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?
additional information
?
-
the enzyme might play an important role in spermiogenesis
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?
additional information
?
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the enzyme might play an important role in spermiogenesis
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?
additional information
?
-
severe hyperammonaemia and high mortality are observed in hCPS deficiency, a rare autosomal disease
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?
additional information
?
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-
severe hyperammonaemia and high mortality are observed in hCPS deficiency, a rare autosomal disease
-
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?
additional information
?
-
-
this enzyme is unable to bind and utilize L-glutamine
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
2 ATP + NH3 + CO2 + H2O
2 ADP + phosphate + carbamoyl phosphate
2 ATP + NH3 + CO2 + H2O
?
2 ATP + NH4+ + HCO3-
2 ADP + phosphate + carbamoyl phosphate
ATP + NH3 + CO2 + H2O
ADP + phosphate + carbamoyl phosphate
ATP + NH3 + CO2 + H2O
ADP + phosphate + carbamoylphosphate
ATP + NH4+ + CO2 + H2O
ADP + phosphate + carbamoyl phosphate
-
-
-
?
ATP + NH4+ + HCO3- + H2O
ADP + phosphate + carbamoyl phosphate
additional information
?
-
2 ATP + NH3 + CO2 + H2O
2 ADP + phosphate + carbamoyl phosphate
-
-
-
-
?
2 ATP + NH3 + CO2 + H2O
2 ADP + phosphate + carbamoyl phosphate
-
-
-
?
2 ATP + NH3 + CO2 + H2O
2 ADP + phosphate + carbamoyl phosphate
-
-
-
-
?
2 ATP + NH3 + CO2 + H2O
2 ADP + phosphate + carbamoyl phosphate
-
-
-
-
?
2 ATP + NH3 + CO2 + H2O
2 ADP + phosphate + carbamoyl phosphate
-
-
-
-
?
2 ATP + NH3 + CO2 + H2O
?
-
plays a key role in the regulation of the urea cycle
-
-
?
2 ATP + NH3 + CO2 + H2O
?
-
primary ammonia-detoxifying enzyme
-
-
?
2 ATP + NH3 + CO2 + H2O
?
-
enzyme is involved in arginine and urea synthesis
-
-
?
2 ATP + NH3 + CO2 + H2O
?
-
primary ammonia-detoxifying enzyme
-
-
?
2 ATP + NH3 + CO2 + H2O
?
-
-
-
-
?
2 ATP + NH3 + CO2 + H2O
?
-
first enzyme involved in the biosynthesis of urea in the liver ureotelic animals
-
-
?
2 ATP + NH3 + CO2 + H2O
?
-
enzyme of urea cycle
-
-
?
2 ATP + NH4+ + HCO3-
2 ADP + phosphate + carbamoyl phosphate
-
-
-
?
2 ATP + NH4+ + HCO3-
2 ADP + phosphate + carbamoyl phosphate
-
-
-
?
2 ATP + NH4+ + HCO3-
2 ADP + phosphate + carbamoyl phosphate
-
-
-
?
2 ATP + NH4+ + HCO3-
2 ADP + phosphate + carbamoyl phosphate
-
-
-
?
2 ATP + NH4+ + HCO3-
2 ADP + phosphate + carbamoyl phosphate
-
-
-
?
2 ATP + NH4+ + HCO3-
2 ADP + phosphate + carbamoyl phosphate
-
-
-
?
ATP + NH3 + CO2 + H2O
ADP + phosphate + carbamoyl phosphate
-
first step of the both the urea cycle and pyrimidine nucleotide biosynthesis patways
-
?
ATP + NH3 + CO2 + H2O
ADP + phosphate + carbamoyl phosphate
-
-
-
?
ATP + NH3 + CO2 + H2O
ADP + phosphate + carbamoyl phosphate
-
the enzyme T1405N genotype influences nitric oxide production as well as vascular smooth muscle reactivity
-
?
ATP + NH3 + CO2 + H2O
ADP + phosphate + carbamoyl phosphate
-
CPS1 is a rate-limiting enzyme in the urea cycle
-
-
?
ATP + NH3 + CO2 + H2O
ADP + phosphate + carbamoyl phosphate
-
the first and rate-limiting step of the urea synthesis
-
?
ATP + NH3 + CO2 + H2O
ADP + phosphate + carbamoyl phosphate
6.3.4.16 carbamoyl-phosphate synthase (ammonia)
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