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Information on EC - carbamoyl-phosphate synthase (ammonia)

for references in articles please use BRENDA:EC6.3.4.16
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IUBMB Comments
The enzyme catalyses the first committed step in the urea cycle. The reaction proceeds via three separate chemical reactions: phosphorylation of hydrogencarbonate to carboxyphosphate; a nucleophilic attack of ammonia on carboxyphosphate yielding carbamate; and the phosphorylation of carbamate forming carbamoyl phosphate. Two moles of ATP are utilized for the synthesis of one molecule of carbamyl phosphate, making the reaction essentially irreversible. The enzyme requires the allosteric activator N-acetyl-L-glutamate. cf. EC, carbamoyl-phosphate synthase (glutamine-hydrolysing).
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The expected taxonomic range for this enzyme is: Eukaryota, Bacteria, Archaea
Reaction Schemes
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carbamoyl phosphate synthetase, cpsase, carbamoyl-phosphate synthetase, carbamoylphosphate synthetase, cps i, cps-i, carbamyl phosphate synthetase i, cps-1, carbamoylphosphate synthase, carbamoyl phosphate synthetase i, more
2 ATP + NH3 + hydrogencarbonate = 2 ADP + phosphate + carbamoyl phosphate
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ATP + carbamate = ADP + carbamoyl phosphate
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ATP + hydrogencarbonate = ADP + carboxyphosphate
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NH3 + carboxyphosphate = carbamate + phosphate
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