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ATP + (2E)-4-[[(2S)-2-amino-2-carboxyethyl]amino]-4-oxobut-2-enoate + L-isoleucine = ADP + phosphate + N-[(2S)-3-[[(2E)-4-amino-4-oxobut-2-enoyl]amino]-2-methylpropanoyl]-L-isoleucine
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ATP + (2E)-4-[[(2S)-2-amino-2-carboxyethyl]amino]-4-oxobut-2-enoate + L-leucine = ADP + phosphate + N-[(2S)-3-[[(2E)-4-amino-4-oxobut-2-enoyl]amino]-2-methylpropanoyl]-L-leucine
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ATP + (2E)-4-[[(2S)-2-amino-2-carboxyethyl]amino]-4-oxobut-2-enoate + L-valine = ADP + phosphate + N-[(2S)-3-[[(2E)-4-amino-4-oxobut-2-enoyl]amino]-2-methylpropanoyl]-L-valine
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ATP + 3-[[[(2R,3R)-3-carboxyoxiran-2-yl]carbonyl]amino]-L-alanine + L-valine = ADP + phosphate + 3-[[[(2R,3R)-3-carboxyoxiran-2-yl]carbonyl]amino]-L-alanyl-L-valine
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ATP + (2E)-4-[[(2S)-2-amino-2-carboxyethyl]amino]-4-oxobut-2-enoate + L-isoleucine
ADP + phosphate + N-[(2S)-3-[[(2E)-4-amino-4-oxobut-2-enoyl]amino]-2-methylpropanoyl]-L-isoleucine
ATP + (2E)-4-[[(2S)-2-amino-2-carboxyethyl]amino]-4-oxobut-2-enoate + L-leucine
ADP + phosphate + N-[(2S)-3-[[(2E)-4-amino-4-oxobut-2-enoyl]amino]-2-methylpropanoyl]-L-leucine
ATP + (2E)-4-[[(2S)-2-amino-2-carboxyethyl]amino]-4-oxobut-2-enoate + L-valine
ADP + phosphate + N-[(2S)-3-[[(2E)-4-amino-4-oxobut-2-enoyl]amino]-2-methylpropanoyl]-L-valine
ATP + 3-[[[(2R,3R)-3-carboxyoxiran-2-yl]carbonyl]amino]-L-alanine + L-valine
ADP + phosphate + 3-[[[(2R,3R)-3-carboxyoxiran-2-yl]carbonyl]amino]-L-alanyl-L-valine
ATP + Nbeta-(R,R)-trans-epoxysuccinamoyl-(2S)-2,3-diaminopropionate + L-valine
ADP + phosphate + Nbeta-(R,R)-trans-epoxysuccinamoyl-(2S)-2,3-diaminopropionyl-L-valine
ATP + Nbeta-(S,S)-trans-epoxysuccinamoyl-(2S)-2,3-diaminopropionate + L-valine
ADP + phosphate + Nbeta-(S,S)-trans-epoxysuccinamoyl-(2S)-2,3-diaminopropionyl-L-valine
kcat/Km for the (S,S)-stereoisomer is 2.5% compared to the kcat/Km-value for the (R,R)-stereoisomer. Nbeta-(S,S)-trans-epoxysuccinamoyl-(2S)-2,3-diaminopropionate i.e. 3-[[[(2S,3S)-3-carboxyoxiran-2-yl]carbonyl]amino]-L-alanine
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additional information
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no activity with Nbeta-fumaroyl-(2S)-2,3-diaminopropionate
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ATP + (2E)-4-[[(2S)-2-amino-2-carboxyethyl]amino]-4-oxobut-2-enoate + L-isoleucine
ADP + phosphate + N-[(2S)-3-[[(2E)-4-amino-4-oxobut-2-enoyl]amino]-2-methylpropanoyl]-L-isoleucine
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ATP + (2E)-4-[[(2S)-2-amino-2-carboxyethyl]amino]-4-oxobut-2-enoate + L-isoleucine
ADP + phosphate + N-[(2S)-3-[[(2E)-4-amino-4-oxobut-2-enoyl]amino]-2-methylpropanoyl]-L-isoleucine
the enzyme is involved in biosynthesis of fumaramoyl- and epoxysuccinamoyl-dipeptides
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ATP + (2E)-4-[[(2S)-2-amino-2-carboxyethyl]amino]-4-oxobut-2-enoate + L-leucine
ADP + phosphate + N-[(2S)-3-[[(2E)-4-amino-4-oxobut-2-enoyl]amino]-2-methylpropanoyl]-L-leucine
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ATP + (2E)-4-[[(2S)-2-amino-2-carboxyethyl]amino]-4-oxobut-2-enoate + L-leucine
ADP + phosphate + N-[(2S)-3-[[(2E)-4-amino-4-oxobut-2-enoyl]amino]-2-methylpropanoyl]-L-leucine
the enzyme is involved in biosynthesis of fumaramoyl- and epoxysuccinamoyl-dipeptides
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ATP + (2E)-4-[[(2S)-2-amino-2-carboxyethyl]amino]-4-oxobut-2-enoate + L-valine
ADP + phosphate + N-[(2S)-3-[[(2E)-4-amino-4-oxobut-2-enoyl]amino]-2-methylpropanoyl]-L-valine
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ATP + (2E)-4-[[(2S)-2-amino-2-carboxyethyl]amino]-4-oxobut-2-enoate + L-valine
ADP + phosphate + N-[(2S)-3-[[(2E)-4-amino-4-oxobut-2-enoyl]amino]-2-methylpropanoyl]-L-valine
the enzyme is involved in biosynthesis of fumaramoyl- and epoxysuccinamoyl-dipeptides
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ATP + 3-[[[(2R,3R)-3-carboxyoxiran-2-yl]carbonyl]amino]-L-alanine + L-valine
ADP + phosphate + 3-[[[(2R,3R)-3-carboxyoxiran-2-yl]carbonyl]amino]-L-alanyl-L-valine
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ATP + 3-[[[(2R,3R)-3-carboxyoxiran-2-yl]carbonyl]amino]-L-alanine + L-valine
ADP + phosphate + 3-[[[(2R,3R)-3-carboxyoxiran-2-yl]carbonyl]amino]-L-alanyl-L-valine
the enzyme is involved in biosynthesis of fumaramoyl- and epoxysuccinamoyl-dipeptides
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ATP + Nbeta-(R,R)-trans-epoxysuccinamoyl-(2S)-2,3-diaminopropionate + L-valine
ADP + phosphate + Nbeta-(R,R)-trans-epoxysuccinamoyl-(2S)-2,3-diaminopropionyl-L-valine
the enzyme is involved ion the biosynthesis of the natural antibiotic Nbeta-epoxysuccinamoyldiaminopropionyl-valine
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ATP + Nbeta-(R,R)-trans-epoxysuccinamoyl-(2S)-2,3-diaminopropionate + L-valine
ADP + phosphate + Nbeta-(R,R)-trans-epoxysuccinamoyl-(2S)-2,3-diaminopropionyl-L-valine
kcat/Km for the (S,S)-stereoisomer is 2.5% compared to the kcat/Km-value for the (R,R)-stereoisomer. Nbeta-(R,R)-trans-epoxysuccinamoyl-(2S)-2,3-diaminopropionate i.e. 3-[[[(2R,3R)-3-carboxyoxiran-2-yl]carbonyl]amino]-L-alanine
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Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
ATP + (2E)-4-[[(2S)-2-amino-2-carboxyethyl]amino]-4-oxobut-2-enoate + L-isoleucine
ADP + phosphate + N-[(2S)-3-[[(2E)-4-amino-4-oxobut-2-enoyl]amino]-2-methylpropanoyl]-L-isoleucine
the enzyme is involved in biosynthesis of fumaramoyl- and epoxysuccinamoyl-dipeptides
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?
ATP + (2E)-4-[[(2S)-2-amino-2-carboxyethyl]amino]-4-oxobut-2-enoate + L-leucine
ADP + phosphate + N-[(2S)-3-[[(2E)-4-amino-4-oxobut-2-enoyl]amino]-2-methylpropanoyl]-L-leucine
the enzyme is involved in biosynthesis of fumaramoyl- and epoxysuccinamoyl-dipeptides
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?
ATP + (2E)-4-[[(2S)-2-amino-2-carboxyethyl]amino]-4-oxobut-2-enoate + L-valine
ADP + phosphate + N-[(2S)-3-[[(2E)-4-amino-4-oxobut-2-enoyl]amino]-2-methylpropanoyl]-L-valine
the enzyme is involved in biosynthesis of fumaramoyl- and epoxysuccinamoyl-dipeptides
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?
ATP + 3-[[[(2R,3R)-3-carboxyoxiran-2-yl]carbonyl]amino]-L-alanine + L-valine
ADP + phosphate + 3-[[[(2R,3R)-3-carboxyoxiran-2-yl]carbonyl]amino]-L-alanyl-L-valine
the enzyme is involved in biosynthesis of fumaramoyl- and epoxysuccinamoyl-dipeptides
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?
ATP + Nbeta-(R,R)-trans-epoxysuccinamoyl-(2S)-2,3-diaminopropionate + L-valine
ADP + phosphate + Nbeta-(R,R)-trans-epoxysuccinamoyl-(2S)-2,3-diaminopropionyl-L-valine
the enzyme is involved ion the biosynthesis of the natural antibiotic Nbeta-epoxysuccinamoyldiaminopropionyl-valine
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Hollenhorst, M.A.; Clardy, J.; Walsh, C.T.
The ATP-dependent amide ligases DdaG and DdaF assemble the fumaramoyl-dipeptide scaffold of the dapdiamide antibiotics
Biochemistry
48
10467-10472
2009
Pantoea agglomerans (E2JA31)
brenda
Hollenhorst, M.A.; Bumpus, S.B.
Matthews, M.L.; Bollinger, J.M.Jr.; Kelleher, N.L.; Walsh, C.T.: The nonribosomal peptide synthetase enzyme DdaD tethers N(beta)-fumaramoyl-l-2,3-diaminopropionate for Fe(II)/alpha-ketoglutarate-dependent epoxidation by DdaC during dapdiamide antibiotic biosynthesis
J. Am. Chem. Soc.
132
15773-15781
2010
Pantoea agglomerans (E2JA31)
brenda
Dawlaty, J.; Zhang, X.; Fischbach, M.A.; Clardy, J.
Dapdiamides, tripeptide antibiotics formed by unconventional amide ligases
J. Nat. Prod.
73
441-446
2010
Pantoea agglomerans (E2JA31)
brenda
6.3.2.B15 3-[[[(2R,3R)-3-carboxyoxiran-2-yl]carbonyl]amino]-L-alanine-L-valine ligase
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