Reference on EC 6.3.2.8 - UDP-N-acetylmuramate-L-alanine ligase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Linnett, P.E.; Tipper, D.J.
Cell wall polymers of Bacillus sphaericus: activities of enzymes involved in peptidoglycan precursor synthesis during sporulation
J. Bacteriol.
120
342-354
1974
Lysinibacillus sphaericus, Lysinibacillus sphaericus 9602
Good, C.M.; Tipper, D.J.
Conditional mutants of Staphylococcus aureus defective in cell wall precursor synthesis
J. Bacteriol.
111
231-241
1972
Staphylococcus aureus
Ito, E.; Strominger, J.L.
Enzymatic synthesis of the peptide in bacterial uridine nucleotides. I. Enzymatic addition of L-alanine, D-glutamic acid, and L-lysine
J. Biol. Chem.
237
2689-2695
1962
Staphylococcus aureus, Staphylococcus aureus Copenhagen
-
Mengin-Lecreulx, D.; Flouret, B.; Van Heijenoort, J.
Cytoplasmic steps of peptidoglycan synthesis in Escherichia coli
J. Bacteriol.
151
1109-1117
1982
Escherichia coli
Ishiguro, E.E.
Inhibition of uridine 5-diphosphate-N-acetylmuramyl-L-alanine synthetase by beta-chloro-L-alanine in Escherichia coli
Can. J. Microbiol.
28
654-659
1982
Escherichia coli
Atherton, F.R.; Hall, M.J.; Hassall, C.H.; Lambert, R.W.; Lloyd, W.J.; Ringrose, P.S.
Phosphonopeptides as antibacterial agents: mechanism of action of alaphosphin
Antimicrob. Agents Chemother.
15
696-705
1979
Staphylococcus aureus
Mizuno, Y.; Yaegashi, M.; Ito, E.
Purification and properties of uridine diphosphate N-acetylmuramate:L-alanine ligase
J. Biochem.
74
525-538
1973
Staphylococcus aureus
Hishinuma, F.; Izaki, K.; Takahashi, H.
Inhibition of L-alanine adding enzyme by glycine
Agric. Biol. Chem.
35
2050-2058
1971
Bacillus cereus, Bacillus subtilis
-
Falk, P.J.; Ervin, K.M.; Volk, K.S.; Ho, H.T.
Biochemical evidence of the formation of a covalent acyl-phosphate linkage between UDP-N-acetylmuramate and ATP in the Escherichia coli UDP-N-acetylmuramate:L-alanine ligase-catalyzed reaction
Biochemistry
35
1417-1422
1996
Escherichia coli
Jin, H.; Emanuele, J.J.; Fairman, R.; Robertson, J.G.; Hail, M.E.; Ho, H.T.; Falk, P.J.; Villafranca, J.J.
Structural studies of Escherichia coli UDP-N-acetylmuramate:L-alanine ligase
Biochemistry
35
1423-1431
1996
Escherichia coli
Liger, D.; Blanot, D.; van Heijenoort, J.
Effect of various alanine analogues on the L-alanine-adding enzyme from Escherichia coli
FEMS Microbiol. Lett.
80
111-116
1991
Escherichia coli, Escherichia coli K12HfrH
Liger, D.; Masson, A.; Blanot, D.; van Heijenoort, J.; Parquet, C.
Study of the overproduced uridine-diphosphate-N-acetylmuramate:L-alanine ligase from Escherichia coli
Microb. Drug Resist.
2
25-27
1996
Escherichia coli
Liger, S.; Masson, A.; Blanot, D.; van Heijenoort, J.; Parquet, C.
Over-production, purification and properties of the uridine-diphosphate-N-acetylmuramate:L-alanine ligase from Escherichia coli
Eur. J. Biochem.
230
80-87
1995
Escherichia coli
Gubler, M.; Appold, Y.; Keck, W.
Overexpression, purification and characterization of UDP-N-acetylmuramyl:L-alanine ligase from Escherichia coli
J. Bacteriol.
178
906-910
1996
Escherichia coli
Emanuele, J.J.; Jin, H.; Jacobson, B.L.; Chang, C.Y.; Einspahr, H.M.; Villafranca, J.J.
Kinetic and crystallographic studies of Escherichia coli UDP-N-acetylmuramate:L-alanine ligase
Protein Sci.
5
2566-2574
1996
Escherichia coli
Emanuele, J.J.; Jin, H.; Yanchunas, J.; Villafranca, J.J.
Evaluation of the kinetic mechanism of Escherichia coli uridine diphosphate-N-acetylmuramate:L-alanine ligase
Biochemistry
36
7264-7271
1997
Escherichia coli
Bouhss, A.; Mengin-Lecreulx, D.; Blanot, D.; van Heijenoort, J.; Parquet, C.
Invariant amino acids in the Mur peptide synthetases of bacterial peptidoglycan synthesis and their modification by site-directed mutagenesis in the UDP-MurNAc;L-alanine ligase from Escherichia coli
Biochemistry
36
11556-11563
1997
Escherichia coli
Deva, T.; Pryor, K.D.; Leiting, B.; Baker, E.N.; Smith, C.A.
Purification, crystallization and preliminary x-ray analysis of Escherichia coli UDP-N-acetylmuramoyl:L-alanine ligase (MurC)
Acta Crystallogr. Sect. D
D59
1510-1513
2003
Escherichia coli (P11880), Escherichia coli
Reck, F.; Marmor, S.; Fisher, S.; Wuonola, M.A.
Inhibitors of the bacterial cell wall biosynthesis enzyme MurC
Bioorg. Med. Chem. Lett.
11
1451-1454
2001
Escherichia coli
Nosal, F.; Masson, A.; Legrand, R.; Blanot, D.; Schoot, B.; van Heijenoort, J.; Parquet, C.
Site-directed mutagenesis and chemical modification of the two cysteine residues of the UDP-N-acetylmuramoyl:L-alanine ligase of Escherichia coli
FEBS Lett.
426
309-313
1998
Escherichia coli
Bouhss, A.; Dementin, S.; van Heijenoort, J.; Parquet, C.; Blanot, D.
Formation of adenosine 5'-tetraphosphate from the acyl phosphate intermediate: a difference between the MurC and MurD synthetases of Escherichia coli
FEBS Lett.
453
15-19
1999
Escherichia coli, Escherichia coli JM83(pAM1005)
El Zoeiby, A.; Sanschagrin, F.; Lamoureux, J.; Darveau, A.; Levesque, R.C.
Cloning, over-expression and purification of Pseudomonas aeruginosa murC encoding uridine diphosphate N-acetylmuramate: L-alanine ligase
FEMS Microbiol. Lett.
183
281-288
2000
Pseudomonas aeruginosa, Pseudomonas aeruginosa CPAO1
Mahapatra, S.; Crick, D.C.; Brennan, P.J.
Comparison of the UDP-N-acetylmuramate:L-alanine ligase enzymes from Mycobacterium tuberculosis and Mycobacterium leprae
J. Bacteriol.
182
6827-6830
2000
Mycobacterium leprae, Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv
Mol, C.D.; Brooun, A.; Dougan, D.R.; Hilgers, M.T.; Tari, L.W.; Wijnands, R.A.; Knuth, M.W.; McRee, D.E.; Swanson, R.V.
Crystal structures of active fully assembled substrate- and product-bound complexes of UDP-N-acetylmuramic acid:L-alanine ligase (MurC) from Haemophilus influenzae
J. Bacteriol.
185
4152-4162
2003
Haemophilus influenzae (P45066)
Hesse, L.; Bostock, J.; Dementin, S.; Blanot, D.; Mengin-Lecreulx, D.; Chopra, I.
Functional and biochemical analysis of Chlamydia trachomatis MurC, an enzyme displaying UDP-N-acetylmuramate:amino acid ligase activity
J. Bacteriol.
185
6507-6512
2003
Chlamydia trachomatis, Chlamydia trachomatis L2
Bouhss, A.; Dementin, S.; Van Heijenoort, J.; Parquet, C.; Blanot, D.
MurC and MurD synthetases of peptidoglycan biosynthesis: borohydride trapping of acyl-phosphate intermediates
Methods Enzymol.
354
189-196
2002
Escherichia coli, Escherichia coli JM83(pAM1005)
Ehmann, D.E.; Demeritt, J.E.; Hull, K.G.; Fisher, S.L.
Biochemical characterization of an inhibitor of Escherichia coli UDP-N-acetylmuramyl-L-alanine ligase
BIOCHIM. BIOPHYS. ACTA
1698
167-174
2004
Escherichia coli
Deng, G.; Gu, R.F.; Marmor, S.; Fisher, S.L.; Jahic, H.; Sanyal, G.
Development of an LC-MS based enzyme activity assay for MurC: application to evaluation of inhibitors and kinetic analysis
J. Pharm. Biomed. Anal.
35
817-828
2004
Escherichia coli
Spraggon, G.; Schwarzenbacher, R.; Kreusch, A.; Lee, C.C.; Abdubek, P.; Ambing, E.; Biorac, T.; Brinen, L.S.; Canaves, J.M.; Cambell, J.; Chiu, H.J.; Dai, X.; Deacon, A.M.; DiDonato, M.; Elsliger, M.A.; Eshagi, S.; Floyd, R.; Godzik, A.et al.
Crystal structure of an Udp-n-acetylmuramate-alanine ligase MurC from Thermotoga maritima at 2.3.ANG. resolution
Proteins
55
1078-1081
2004
Thermotoga maritima (Q9WY73), Thermotoga maritima, Thermotoga maritima MSB8 / DSM 3109 / ATCC 43589 (Q9WY73)
Deva, T.; Baker, E.N.; Squire, C.J.; Smith, C.A.
Structure of Escherichia coli UDP-N-acetylmuramoyl:L-alanine ligase (MurC)
Acta Crystallogr. Sect. D
62
1466-1474
2006
Escherichia coli (P17952), Escherichia coli
Sink, R.; Kovac, A.; Tomasi?, T.; Rupnik, V.; Boniface, A.; Bostock, J.; Chopra, I.; Blanot, D.; Masic, L.P.; Gobec, S.; Zega, A.
Synthesis and biological evaluation of N-acylhydrazones as inhibitors of MurC and MurD ligases
ChemMedChem
3
1362-1370
2008
Escherichia coli
Fiuza, M.; Canova, M.J.; Patin, D.; Letek, M.; Zanella-Cleon, I.; Becchi, M.; Mateos, L.M.; Mengin-Lecreulx, D.; Molle, V.; Gil, J.A.
The MurC ligase essential for peptidoglycan biosynthesis is regulated by the serine/threonine protein kinase PknA in Corynebacterium glutamicum
J. Biol. Chem.
283
36553-36563
2008
Corynebacterium glutamicum
Frlan, R.; Kovac, A.; Blanot, D.; Gobec, S.; Pecar, S.; Obreza, A.
Design and synthesis of novel N-benzylidenesulfonohydrazide inhibitors of MurC and MurD as potential antibacterial agents
Molecules
13
11-30
2008
Escherichia coli
Anuradha, C.M.; Mulakayala, C.; Babajan, B.; Naveen, M.; Rajasekhar, C.; Kumar, C.S.
Probing ligand binding modes of Mycobacterium tuberculosis MurC ligase by molecular modeling, dynamics simulation and docking
J. Mol. Model.
16
77-85
2009
Mycobacterium tuberculosis
Patin, D.; Boniface, A.; Kovac, A.; Herv, M.; Dementin, S.; Barreteau, H.; Mengin-Lecreulx, D.; Blanot, D.
Purification and biochemical characterization of Mur ligases from Staphylococcus aureus
Biochimie
92
1793-1800
2010
Staphylococcus aureus
Tomasic, T.; Kovac, A.; Klebe, G.; Blanot, D.; Gobec, S.; Kikelj, D.; Masic, L.P.
Virtual screening for potential inhibitors of bacterial MurC and MurD ligases
J. Mol. Model.
18
1063-1072
2012
Escherichia coli (P17952)
Shanmugam, A.; Natarajan, J.
Comparative modeling of UDP-N-acetylmuramoyl-glycyl-D-glutamate-2,6-diaminopimelate ligase from Mycobacterium leprae and analysis of its binding features through molecular docking studies
J. Mol. Model.
18
115-125
2012
Mycobacterium leprae (P57994)
Rausch, S.; Haenchen, A.; Denisiuk, A.; Loehken, M.; Schneider, T.; Suessmuth, R.
Feglymycin is an inhibitor of the enzymes MurA and MurC of the peptidoglycan biosynthesis pathway
ChemBioChem
12
1171-1173
2011
Escherichia coli, Staphylococcus aureus
Munshi, T.; Gupta, A.; Evangelopoulos, D.; Guzman, J.D.; Gibbons, S.; Keep, N.H.; Bhakta, S.
Characterisation of ATP-dependent Mur ligases involved in the biogenesis of cell wall peptidoglycan in Mycobacterium tuberculosis
PLoS ONE
8
e60143
2013
Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv
Hameed P, S.; Manjrekar, P.; Chinnapattu, M.; Humnabadkar, V.; Shanbhag, G.; Kedari, C.; Mudugal, N.V.; Ambady, A.; de Jonge, B.L.; Sadler, C.; Paul, B.; Sriram, S.; Kaur, P.; Guptha, S.; Raichurkar, A.; Fleming, P.; Eyermann, C.J.; McKinney, D.C.; Sambandamurthy, V.K.; Panda, M.; Ravishankar, S.
Pyrazolopyrimidines establish MurC as a vulnerable target in Pseudomonas aeruginosa and Escherichia coli
ACS Chem. Biol.
9
2274-2282
2014
Escherichia coli, Pseudomonas aeruginosa, Pseudomonas aeruginosa Pae546
Humnabadkar, V.; Prabhakar, K.R.; Narayan, A.; Sharma, S.; Guptha, S.; Manjrekar, P.; Chinnapattu, M.; Ramachandran, V.; Hameed, S.P.; Ravishankar, S.; Chatterji, M.
UDP-N-acetylmuramic acid L-alanine ligase (MurC) inhibition in a tolC mutant Escherichia coli strain leads to cell death
Antimicrob. Agents Chemother.
58
6165-6171
2014
Escherichia coli, Pseudomonas aeruginosa
Naqvi, K.F.; Patin, D.; Wheatley, M.S.; Savka, M.A.; Dobson, R.C.; Gan, H.M.; Barreteau, H.; Blanot, D.; Mengin-Lecreulx, D.; Hudson, A.O.
Identification and partial characterization of a novel UDP-N-acetylenolpyruvoylglucosamine reductase/UDP-N-acetylmuramate L-alanine ligase fusion enzyme from Verrucomicrobium spinosum DSM 4136(T)
Front. Microbiol.
7
362
2016
Verrucomicrobium spinosum, Verrucomicrobium spinosum DSM 4136
Videau, P.; Rivers, O.S.; Ushijima, B.; Oshiro, R.T.; Kim, M.J.; Philmus, B.; Cozy, L.M.
Mutation of the murC and murB genes impairs heterocyst differentiation in Anabaena sp. strain PCC 7120
J. Bacteriol.
198
1196-1206
2016
Nostoc sp. PCC 7120 = FACHB-418 (Q8YM75), Nostoc sp. PCC 7120 = FACHB-418 SAG 25.82 / UTEX 2576 (Q8YM75)
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