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A key enzyme in the production of coenzyme A. The eukaryotic enzyme requires ATP, in contrast to the bacterial enzyme, EC 188.8.131.52, phosphopantothenate---cysteine ligase, which requires CTP.
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The expected taxonomic range for this enzyme is: Eukaryota, Archaea, Bacteria
4'-phosphopantothenoylcysteine synthetase, CoaB
, Dfp, phosphopantothenoylcysteine synthetase, PPC synthetase, PPC-synthetase, PPCS
ATP + (R)-4'-phosphopantothenate + L-cysteine = AMP + diphosphate + N-[(R)-4'-phosphopantothenoyl]-L-cysteine
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