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EC Tree
IUBMB Comments The enzyme, found in mammals, also has the activity of EC 6.3.2.41, N-acetylaspartylglutamate synthase.
The enzyme appears in viruses and cellular organisms
Synonyms
N-acetylaspartylglutamate synthetase II, N-acetylaspartylglutamylglutamate synthetase, NAAG synthetase II, NAAG(2) synthase, NAAGS-II,
RIMKLA ,
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N-acetylaspartylglutamate synthetase II
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N-acetylaspartylglutamylglutamate synthetase
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RIMKLA
gene name, ambiguous
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2 ATP + N-acetyl-L-aspartate + 2 L-glutamate = 2 ADP + 2 phosphate + N-acetyl-L-aspartyl-L-glutamyl-L-glutamate
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N-acetyl-L-aspartate:L-glutamate ligase (ADP, N-acetyl-L-aspartyl-L-glutamyl-L-glutamate-forming)
The enzyme, found in mammals, also has the activity of EC 6.3.2.41, N-acetylaspartylglutamate synthase.
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2 ATP + N-acetyl-L-aspartate + 2 L-glutamate
2 ADP + 2 phosphate + N-acetyl-L-aspartyl-L-glutamyl-L-glutamate
ATP + N-acetyl-L-aspartate + L-glutamate
ADP + phosphate + N-acetyl-L-aspartyl-L-glutamyl-L-glutamate
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2 ATP + N-acetyl-L-aspartate + 2 L-glutamate
2 ADP + 2 phosphate + N-acetyl-L-aspartyl-L-glutamyl-L-glutamate
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2 ATP + N-acetyl-L-aspartate + 2 L-glutamate
2 ADP + 2 phosphate + N-acetyl-L-aspartyl-L-glutamyl-L-glutamate
the enzyme also has the activity of EC 6.3.2.41, N-acetylaspartylglutamate synthase
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Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
2 ATP + N-acetyl-L-aspartate + 2 L-glutamate
2 ADP + 2 phosphate + N-acetyl-L-aspartyl-L-glutamyl-L-glutamate
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ATP + N-acetyl-L-aspartate + L-glutamate
ADP + phosphate + N-acetyl-L-aspartyl-L-glutamyl-L-glutamate
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SwissProt
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highest expression levels in the brain stem and spinal cord, almost undetectable in the neocortex
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strong expression is restricted to deep cerebellar nuclei
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expression is found in the ventral and dorsal horns of gray matter in laminae III to X, but is low or absent in laminae I and II
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RIMKA_HUMAN
391
0
42864
Swiss-Prot
other Location (Reliability: 5 )
RIMKA_MOUSE
380
0
41504
Swiss-Prot
other Location (Reliability: 3 )
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42000
x * 42000, SDS-PAGE
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expressed as FLAG epitope-tagged protein in HEK-293T and CHO-K1 cells
expressed as FLAG epitope-tagged protein in HEK-293T and CHO-K1 cells. Because hexahistidine-tagged Escherichia coli-expressed enzyme using bacterial expressed protein
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Lodder-Gadaczek, J.; Becker, I.; Gieselmann, V.; Wang-Eckhardt, L.; Eckhardt, M.
N-Acetylaspartylglutamate synthetase II synthesizes N-acetylaspartylglutamylglutamate
J. Biol. Chem.
286
16693-16706
2011
Mus musculus, Mus musculus (Q6PFX8)
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