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Synonyms RIMKLA ,
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N-acetylaspartylglutamate synthetase II
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N-acetylaspartylglutamylglutamate synthetase
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NAAG hydrolase glutamate carboxypeptidase II
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NAAG synthetase II
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NAAGS-II
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RIMKLA
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RIMKLA
gene name, ambiguous
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2 ATP + N-acetyl-L-aspartate + 2 L-glutamate = 2 ADP + 2 phosphate + N-acetyl-L-aspartyl-L-glutamyl-L-glutamate
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N-acetyl-L-aspartate:L-glutamate ligase (ADP, N-acetyl-L-aspartyl-L-glutamyl-L-glutamate-forming)
The enzyme, found in mammals, also has the activity of EC 6.3.2.41, N-acetylaspartylglutamate synthase.
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2 ATP + N-acetyl-L-aspartate + 2 L-glutamate
2 ADP + 2 phosphate + N-acetyl-L-aspartyl-L-glutamyl-L-glutamate
ATP + N-acetyl-L-aspartate + L-glutamate
ADP + phosphate + N-acetyl-L-aspartyl-L-glutamyl-L-glutamate
Substrates: -
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2 ATP + N-acetyl-L-aspartate + 2 L-glutamate
2 ADP + 2 phosphate + N-acetyl-L-aspartyl-L-glutamyl-L-glutamate
Substrates: -
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2 ATP + N-acetyl-L-aspartate + 2 L-glutamate
2 ADP + 2 phosphate + N-acetyl-L-aspartyl-L-glutamyl-L-glutamate
Substrates: the enzyme also has the activity of EC 6.3.2.41, N-acetylaspartylglutamate synthase
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2 ATP + N-acetyl-L-aspartate + 2 L-glutamate
2 ADP + 2 phosphate + N-acetyl-L-aspartyl-L-glutamyl-L-glutamate
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Substrates: -
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2 ATP + N-acetyl-L-aspartate + 2 L-glutamate
2 ADP + 2 phosphate + N-acetyl-L-aspartyl-L-glutamyl-L-glutamate
ATP + N-acetyl-L-aspartate + L-glutamate
ADP + phosphate + N-acetyl-L-aspartyl-L-glutamyl-L-glutamate
Substrates: -
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2 ATP + N-acetyl-L-aspartate + 2 L-glutamate
2 ADP + 2 phosphate + N-acetyl-L-aspartyl-L-glutamyl-L-glutamate
Substrates: -
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2 ATP + N-acetyl-L-aspartate + 2 L-glutamate
2 ADP + 2 phosphate + N-acetyl-L-aspartyl-L-glutamyl-L-glutamate
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Substrates: -
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SwissProt
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highest expression levels in the brain stem and spinal cord, almost undetectable in the neocortex
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in hippocampus, the enzyme is detectable in neurons expressing parvalbumin
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most abundant
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strong expression is restricted to deep cerebellar nuclei
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expression is found in the ventral and dorsal horns of gray matter in laminae III to X, but is low or absent in laminae I and II
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most abundant
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Highest Expressing Human Cell Lines
Filter by:
Cell Line Links
Gene Links
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malfunction
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mice deficient in the enzyme gene are impaired in a novel object recognition task
physiological function
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N-acetyl-L-aspartyl-L-glutamate synthesized by the enzyme is directly involved in the memory consolidation underlying the novel object recognition task
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RIMKA_MOUSE
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41504
Swiss-Prot
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42000
x * 42000, SDS-PAGE
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x * 42000, SDS-PAGE
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x * about 50000, SDS-PAGE
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expressed as FLAG epitope-tagged protein in HEK-293T and CHO-K1 cells
expressed as FLAG epitope-tagged protein in HEK-293T and CHO-K1 cells. Because hexahistidine-tagged Escherichia coli-expressed enzyme using bacterial expressed protein
expressed in HeLa cells
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Lodder-Gadaczek, J.; Becker, I.; Gieselmann, V.; Wang-Eckhardt, L.; Eckhardt, M.
N-Acetylaspartylglutamate synthetase II synthesizes N-acetylaspartylglutamylglutamate
J. Biol. Chem.
286
16693-16706
2011
Mus musculus, Mus musculus (Q6PFX8)
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Becker, I.; Wang-Eckhardt, L.; Lodder-Gadaczek, J.; Wang, Y.; Gruenewald, A.; Eckhardt, M.
Mice deficient in the NAAG synthetase II gene Rimkla are impaired in a novel object recognition task
J. Neurochem.
157
2008-2023
2021
Mus musculus
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