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Information on EC 6.3.2.38 - N2-citryl-N6-acetyl-N6-hydroxylysine synthase

for references in articles please use BRENDA:EC6.3.2.38

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IUBMB Comments

Requires Mg2+. The enzyme is involved in the biosynthesis of aerobactin, a dihydroxamate siderophore. It belongs to a class of siderophore synthases known as type A nonribosomal peptide synthase-independent synthases (NIS). Type A enzymes are responsible for the formation of amide or ester bonds between polyamines or amino alcohols and a prochiral carboxyl group of citrate. The enzyme is believed to form an adenylate intermediate prior to ligation.

The enzyme appears in viruses and cellular organisms

Synonyms
aerD, EC 6.3.2.27, iuacA, iucA, Nalpha-citryl-Nepsilon-acetyl-Nepsilon-hydroxylysine synthase, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
2 ATP + citrate + N6-acetyl-N6-hydroxy-L-lysine + H2O = 2 ADP + 2 phosphate + N6-acetyl-N2-citryl-N6-hydroxy-L-lysine
show the reaction diagram
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