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Information on EC 6.3.2.38 - N2-citryl-N6-acetyl-N6-hydroxylysine synthase for references in articles please use BRENDA:EC6.3.2.38Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
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The enzyme appears in viruses and cellular organisms
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N2-citryl-N6-acetyl-N6-hydroxylysine synthase
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2 ATP + citrate + N6-acetyl-N6-hydroxy-L-lysine + H2O = 2 ADP + 2 phosphate + N2-citryl-N6-acetyl-N6-hydroxy-L-lysine
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aerobactin biosynthesis
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Microbial metabolism in diverse environments
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citrate:N6-acetyl-N6-hydroxy-L-lysine ligase (ADP-forming)
Requires Mg2+. Aerobactin is one of a group of high-affinity iron chelators known as siderophores and is produced under conditions of iron deprivation [5]. It is a dihydroxamate comprising two molecules of N6-acetyl-N6-hydroxy-L-lysine and one molecule of citrate. This enzyme catalyses the first of two synthase reactions to link N6-acetyl-N6-hydroxy-L-lysine and citrate [4,5].
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Nalpha-citryl-Nepsilon-acetyl-Nepsilon-hydroxylysine synthase
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iucA
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gene name
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brenda
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SwissProt
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2 alpha,beta-methylene-ATP + citrate + N6-acetyl-N6-hydroxy-L-lysine + H2O
2 alpha,beta-methylene-ADP + 2 phosphate + N2-citryl-N6-acetyl-N6-hydroxy-L-lysine
2 ATP + citrate + N6-acetyl-N6-hydroxy-L-lysine + H2O
2 ADP + 2 phosphate + N2-citryl-N6-acetyl-N6-hydroxy-L-lysine
2 alpha,beta-methylene-ATP + citrate + N6-acetyl-N6-hydroxy-L-lysine + H2O
2 alpha,beta-methylene-ADP + 2 phosphate + N2-citryl-N6-acetyl-N6-hydroxy-L-lysine
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no activity with beta-gamma-ATP
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2 alpha,beta-methylene-ATP + citrate + N6-acetyl-N6-hydroxy-L-lysine + H2O
2 alpha,beta-methylene-ADP + 2 phosphate + N2-citryl-N6-acetyl-N6-hydroxy-L-lysine
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no activity with beta-gamma-ATP
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2 ATP + citrate + N6-acetyl-N6-hydroxy-L-lysine + H2O
2 ADP + 2 phosphate + N2-citryl-N6-acetyl-N6-hydroxy-L-lysine
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2 ATP + citrate + N6-acetyl-N6-hydroxy-L-lysine + H2O
2 ADP + 2 phosphate + N2-citryl-N6-acetyl-N6-hydroxy-L-lysine
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2 ATP + citrate + N6-acetyl-N6-hydroxy-L-lysine + H2O
2 ADP + 2 phosphate + N2-citryl-N6-acetyl-N6-hydroxy-L-lysine
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the enzyme is involved in biosynthesis of aerobactin
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2 ATP + citrate + N6-acetyl-N6-hydroxy-L-lysine + H2O
2 ADP + 2 phosphate + N2-citryl-N6-acetyl-N6-hydroxy-L-lysine
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2 ATP + citrate + N6-acetyl-N6-hydroxy-L-lysine + H2O
2 ADP + 2 phosphate + N2-citryl-N6-acetyl-N6-hydroxy-L-lysine
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the enzyme catalyses the second of two synthase reactions to link N6-acetyl-N6-hydroxy-L-lysine and citrate in biosynthesis of aerobactin. Aerobactin is excreted by cultures of Aerobacter aerogenes 62-I and related strains when growing in an iron-deficient medium
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2 ATP + citrate + N6-acetyl-N6-hydroxy-L-lysine + H2O
2 ADP + 2 phosphate + N2-citryl-N6-acetyl-N6-hydroxy-L-lysine
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absolute requirement for ATP in aerobactin production. Other nucleoside triphosphates (UTP, CTP and GTP) are not effective in promoting aerobactin synthesis. Utilization of ATP (decrease in its concentration) is also noted when L-lysine or glycine or L-norleucine is used in the place of N6-acetyl-N6-hydroxylysine
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2 ATP + citrate + N6-acetyl-N6-hydroxy-L-lysine + H2O
2 ADP + 2 phosphate + N2-citryl-N6-acetyl-N6-hydroxy-L-lysine
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2 ATP + citrate + N6-acetyl-N6-hydroxy-L-lysine + H2O
2 ADP + 2 phosphate + N2-citryl-N6-acetyl-N6-hydroxy-L-lysine
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absolute requirement for ATP in aerobactin production. Other nucleoside triphosphates (UTP, CTP and GTP) are not effective in promoting aerobactin synthesis. Utilization of ATP (decrease in its concentration) is also noted when L-lysine or glycine or L-norleucine is used in the place of N6-acetyl-N6-hydroxylysine
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2 ATP + citrate + N6-acetyl-N6-hydroxy-L-lysine + H2O
2 ADP + 2 phosphate + N2-citryl-N6-acetyl-N6-hydroxy-L-lysine
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the enzyme catalyses the second of two synthase reactions to link N6-acetyl-N6-hydroxy-L-lysine and citrate in biosynthesis of aerobactin. Aerobactin is excreted by cultures of Aerobacter aerogenes 62-I and related strains when growing in an iron-deficient medium
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2 ATP + citrate + N6-acetyl-N6-hydroxy-L-lysine + H2O
2 ADP + 2 phosphate + N2-citryl-N6-acetyl-N6-hydroxy-L-lysine
2 ATP + citrate + N6-acetyl-N6-hydroxy-L-lysine + H2O
2 ADP + 2 phosphate + N2-citryl-N6-acetyl-N6-hydroxy-L-lysine
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2 ATP + citrate + N6-acetyl-N6-hydroxy-L-lysine + H2O
2 ADP + 2 phosphate + N2-citryl-N6-acetyl-N6-hydroxy-L-lysine
Q47316
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2 ATP + citrate + N6-acetyl-N6-hydroxy-L-lysine + H2O
2 ADP + 2 phosphate + N2-citryl-N6-acetyl-N6-hydroxy-L-lysine
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the enzyme is involved in biosynthesis of aerobactin
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?
2 ATP + citrate + N6-acetyl-N6-hydroxy-L-lysine + H2O
2 ADP + 2 phosphate + N2-citryl-N6-acetyl-N6-hydroxy-L-lysine
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2 ATP + citrate + N6-acetyl-N6-hydroxy-L-lysine + H2O
2 ADP + 2 phosphate + N2-citryl-N6-acetyl-N6-hydroxy-L-lysine
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the enzyme catalyses the second of two synthase reactions to link N6-acetyl-N6-hydroxy-L-lysine and citrate in biosynthesis of aerobactin. Aerobactin is excreted by cultures of Aerobacter aerogenes 62-I and related strains when growing in an iron-deficient medium
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?
2 ATP + citrate + N6-acetyl-N6-hydroxy-L-lysine + H2O
2 ADP + 2 phosphate + N2-citryl-N6-acetyl-N6-hydroxy-L-lysine
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?
2 ATP + citrate + N6-acetyl-N6-hydroxy-L-lysine + H2O
2 ADP + 2 phosphate + N2-citryl-N6-acetyl-N6-hydroxy-L-lysine
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the enzyme catalyses the second of two synthase reactions to link N6-acetyl-N6-hydroxy-L-lysine and citrate in biosynthesis of aerobactin. Aerobactin is excreted by cultures of Aerobacter aerogenes 62-I and related strains when growing in an iron-deficient medium
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p-chloromercuribenzoate
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IUCA_VIBMI
598
67795
Swiss-Prot
IUCA_ECOLX
575
65570
Swiss-Prot
A0A1Q2ZC15_9ACTN
565
61217
TrEMBL
A0A090TXZ7_9VIBR
673
75917
TrEMBL
A0A1Q9B5S2_BACPU
593
67867
TrEMBL
A0A1D2IJQ5_9ACTN
543
59263
TrEMBL
A0A1K2G135_9ACTN
625
67335
TrEMBL
A0A1Y2NS77_STRFR
593
61796
TrEMBL
A0A0M3FFS4_ACIBA
594
68162
TrEMBL
T2K1T3_ECOLX
574
65349
TrEMBL
A0A1D8G8V0_9ACTN
596
62039
TrEMBL
A0A2U3MKR0_9NEIS
594
68056
TrEMBL
A0A2P9EWH3_9ACTN
500
52848
TrEMBL
A0A2P8A3P0_9ACTN
648
69056
TrEMBL
A0A177HVS3_9ACTN
747
79955
TrEMBL
A0A0K6MFE1_BACIU
321
37175
TrEMBL
A0A1B9EWB4_9ACTN
629
67894
TrEMBL
A0A128FJB8_9GAMM
596
67866
TrEMBL
A0A150I2I4_9GAMM
594
68765
TrEMBL
A0A1B8NVG6_HALEL
603
68658
TrEMBL
A0A0U5LXF8_STRRE
498
53806
TrEMBL
A0A100J5T9_9ACTN
565
61302
TrEMBL
A0A2N9B401_STRCX
517
55772
TrEMBL
A0A150HSU4_9GAMM
594
68528
TrEMBL
A0A2R8CJP4_9GAMM
592
66124
TrEMBL
A0A177W4D9_9GAMM
622
72412
TrEMBL
A0A165UPK2_9RHOB
606
67180
TrEMBL
A0A1W6TW32_VIBAL
609
69477
TrEMBL
A0A090RZ09_9VIBR
133
14880
TrEMBL
A0A2N9B5I1_STRCX
737
78281
TrEMBL
A0A100JQD6_STRSC
500
53183
TrEMBL
A0A100JXI7_STRSC
570
62225
TrEMBL
S0ADF2_SERPL
581
65377
TrEMBL
A0A1A7KEX1_9FLAO
806
94023
TrEMBL
A0A1Y6AS39_BACCE
602
69740
TrEMBL
A0A2K8R1V5_9ACTN
602
65718
TrEMBL
A0A0A0GQC4_ECOLX
574
64965
TrEMBL
A0A2S9YVB4_9DELT
925
102494
TrEMBL
A0A2S9XIC9_9DELT
925
102693
TrEMBL
A0A1R3U7G4_9RHIZ
584
63797
TrEMBL
A0A239RT59_ACIJO
594
68220
TrEMBL
A0A2S5CV82_LYSSH
564
66302
TrEMBL
A0A1X7ALM9_9GAMM
593
66589
TrEMBL
A0A0D5YI12_ACIBA
594
68196
TrEMBL
A0A1G5M1R0_ACIBA
172
19921
TrEMBL
A0A1W5DEV1_9GAMM
581
65790
TrEMBL
A0A2K8PAG5_STRLA
466
49192
TrEMBL
A0A2P9EUW2_9ACTN
785
83881
TrEMBL
A0A2N9B3Z8_STRCX
498
53234
TrEMBL
A0A100JQM6_STRSC
835
89322
TrEMBL
A0A2S6X3L5_9ACTN
509
55118
TrEMBL
A0A2G4B3K4_VIBSP
621
70716
TrEMBL
A0A128FGL1_9GAMM
596
67766
TrEMBL
A0A2K8RF07_9ACTN
652
70137
TrEMBL
A0A166ELH9_9RHOB
611
68044
TrEMBL
A0A221W270_9PSEU
603
64551
TrEMBL
A0A1Q2Z827_9ACTN
536
58714
TrEMBL
A0A117EEC1_STRSC
543
58224
TrEMBL
A0A2S6X3R3_9ACTN
508
53641
TrEMBL
A0A1V2REF5_9ACTN
617
65862
TrEMBL
W7PAY2_9ENTR
580
65665
TrEMBL
A0A1R7QE85_ACIJO
594
68210
TrEMBL
A0A1Y2NFX5_STRPT
593
63815
TrEMBL
A0A117E5X3_9ACTN
451
48572
TrEMBL
A0A2P9EWE5_9ACTN
533
56912
TrEMBL
A0A2X0TIC5_PAEPO
574
65535
TrEMBL
A0A0F7M163_9GAMM
616
69662
TrEMBL
A0A165W8R6_9RHOB
611
67738
TrEMBL
A0A0U5LUK6_STRRE
504
53693
TrEMBL
A0A177HGF0_9ACTN
594
63764
TrEMBL
A0A075R1W3_BRELA
599
68607
TrEMBL
A0A0U5L718_9GAMM
580
65411
TrEMBL
A0A1A8TI20_9GAMM
603
68530
TrEMBL
A0A2J7W4F2_9BURK
595
66956
TrEMBL
A0A0B0HR42_9BACI
192
23024
TrEMBL
A0A2S9XZW6_9BACI
602
69911
TrEMBL
A0A1K2FN45_9ACTN
502
53893
TrEMBL
A0A1V2MJZ3_9ACTN
644
70069
TrEMBL
A0A2H1LBA0_9GAMM
581
65835
TrEMBL
A0A100J4I8_9ACTN
383
42653
TrEMBL
A0A0P1G034_9RHOB
586
65335
TrEMBL
A0A2S6XEA4_9ACTN
666
70848
TrEMBL
A0A2P8A247_9ACTN
514
55320
TrEMBL
A0A1Y2NC82_STRPT
674
73250
TrEMBL
A0A2X3KIT1_9ACTN
554
59289
TrEMBL
A0A2K8PD44_STRLA
1006
104732
TrEMBL
A0A161WWG1_9RHOB
611
68116
TrEMBL
A0A1Y0XGK3_BACLI
588
67111
TrEMBL
A0A2R8CJI3_9GAMM
578
64373
TrEMBL
A0A2P8A234_9ACTN
508
53557
TrEMBL
A0A2S0XDS4_9RHIZ
593
66186
TrEMBL
A0A2P4UID2_9ACTN
529
57185
TrEMBL
A0A2K8P7K4_STRLA
511
54993
TrEMBL
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Lorenzo de, V.; Bindereif, A.; Paw, B.H.; Neilands, J.B.
Aerobactin biosynthesis and transport genes of plasmid ColV-K30 in Escherichia coli K-12
J. Bacteriol.
165
570-578
1986
Escherichia coli (Q47316)
brenda
Appanna, D.L.; Grundy, B.J.; Szczepan, E.W.; Viswanatha, T.
Aerobactin synthesis in a cell-free system of Aerobacter aerogenes 62-1
Biochim. Biophys. Acta
801
437-443
1984
Klebsiella aerogenes, Klebsiella aerogenes 62-1
-
brenda
Gibson, F.; Magrath, D.I.
The isolation and characterization of a hydroxamic acid (aerobactin) formed by Aerobacter aerogenes 62-I
Biochim. Biophys. Acta
192
175-184
1969
Klebsiella aerogenes, Klebsiella aerogenes 62-1
brenda
Challis, G.L.
A widely distributed bacterial pathway for siderophore biosynthesis independent of nonribosomal peptide synthetases
ChemBioChem
6
601-611
2005
Escherichia coli
brenda
Gross, R.; Engelbrecht, F.; Braun, V.
Identification of the genes and their polypeptide products responsible for aerobactin synthesis by pColV plasmids
Mol. Gen. Genet.
201
204-212
1985
Escherichia coli
brenda
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