Requires Mg2+. The enzyme is involved in the biosynthesis of aerobactin, a dihydroxamate siderophore. It belongs to a class of siderophore synthases known as type A nonribosomal peptide synthase-independent synthases (NIS). Type A enzymes are responsible for the formation of amide or ester bonds between polyamines or amino alcohols and a prochiral carboxyl group of citrate. The enzyme is believed to form an adenylate intermediate prior to ligation.
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The enzyme appears in viruses and cellular organisms
Requires Mg2+. The enzyme is involved in the biosynthesis of aerobactin, a dihydroxamate siderophore. It belongs to a class of siderophore synthases known as type A nonribosomal peptide synthase-independent synthases (NIS). Type A enzymes are responsible for the formation of amide or ester bonds between polyamines or amino alcohols and a prochiral carboxyl group of citrate. The enzyme is believed to form an adenylate intermediate prior to ligation.
the enzyme catalyses the second of two synthase reactions to link N6-acetyl-N6-hydroxy-L-lysine and citrate in biosynthesis of aerobactin. Aerobactin is excreted by cultures of Aerobacter aerogenes 62-I and related strains when growing in an iron-deficient medium
absolute requirement for ATP in aerobactin production. Other nucleoside triphosphates (UTP, CTP and GTP) are not effective in promoting aerobactin synthesis. Utilization of ATP (decrease in its concentration) is also noted when L-lysine or glycine or L-norleucine is used in the place of N6-acetyl-N6-hydroxylysine
absolute requirement for ATP in aerobactin production. Other nucleoside triphosphates (UTP, CTP and GTP) are not effective in promoting aerobactin synthesis. Utilization of ATP (decrease in its concentration) is also noted when L-lysine or glycine or L-norleucine is used in the place of N6-acetyl-N6-hydroxylysine
the enzyme catalyses the second of two synthase reactions to link N6-acetyl-N6-hydroxy-L-lysine and citrate in biosynthesis of aerobactin. Aerobactin is excreted by cultures of Aerobacter aerogenes 62-I and related strains when growing in an iron-deficient medium
the enzyme catalyses the second of two synthase reactions to link N6-acetyl-N6-hydroxy-L-lysine and citrate in biosynthesis of aerobactin. Aerobactin is excreted by cultures of Aerobacter aerogenes 62-I and related strains when growing in an iron-deficient medium
the enzyme catalyses the second of two synthase reactions to link N6-acetyl-N6-hydroxy-L-lysine and citrate in biosynthesis of aerobactin. Aerobactin is excreted by cultures of Aerobacter aerogenes 62-I and related strains when growing in an iron-deficient medium
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Enzyme Nomenclature
6.3.2.38 N2-citryl-N6-acetyl-N6-hydroxylysine synthase
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