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Enzyme Nomenclature
Information on EC 6.3.2.38 - N2-citryl-N6-acetyl-N6-hydroxylysine synthase
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The enzyme appears in viruses and cellular organisms
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EC NUMBER 
COMMENTARY 
6.3.2.38
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RECOMMENDED NAME
GeneOntology No.
N2-citryl-N6-acetyl-N6-hydroxylysine synthase
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
2 ATP + citrate + N6-acetyl-N6-hydroxy-L-lysine + H2O = 2 ADP + 2 phosphate + N2-citryl-N6-acetyl-N6-hydroxy-L-lysine
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
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SYSTEMATIC NAME
IUBMB Comments
citrate:N6-acetyl-N6-hydroxy-L-lysine ligase (ADP-forming)
Requires Mg2+. Aerobactin is one of a group of high-affinity iron chelators known as siderophores and is produced under conditions of iron deprivation [5]. It is a dihydroxamate comprising two molecules of N6-acetyl-N6-hydroxy-L-lysine and one molecule of citrate. This enzyme catalyses the first of two synthase reactions to link N6-acetyl-N6-hydroxy-L-lysine and citrate [4,5].
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CAS REGISTRY NUMBER
COMMENTARY
94047-30-0
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ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
2 alpha,beta-methylene-ATP + citrate + N6-acetyl-N6-hydroxy-L-lysine + H2O
2 alpha,beta-methylene-ADP + 2 phosphate + N2-citryl-N6-acetyl-N6-hydroxy-L-lysine
2 ATP + citrate + N6-acetyl-N6-hydroxy-L-lysine + H2O
2 ADP + 2 phosphate + N2-citryl-N6-acetyl-N6-hydroxy-L-lysine
2 alpha,beta-methylene-ATP + citrate + N6-acetyl-N6-hydroxy-L-lysine + H2O
2 alpha,beta-methylene-ADP + 2 phosphate + N2-citryl-N6-acetyl-N6-hydroxy-L-lysine
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no activity with beta-gamma-ATP
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2 alpha,beta-methylene-ATP + citrate + N6-acetyl-N6-hydroxy-L-lysine + H2O
2 alpha,beta-methylene-ADP + 2 phosphate + N2-citryl-N6-acetyl-N6-hydroxy-L-lysine
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no activity with beta-gamma-ATP
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2 ATP + citrate + N6-acetyl-N6-hydroxy-L-lysine + H2O
2 ADP + 2 phosphate + N2-citryl-N6-acetyl-N6-hydroxy-L-lysine
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2 ATP + citrate + N6-acetyl-N6-hydroxy-L-lysine + H2O
2 ADP + 2 phosphate + N2-citryl-N6-acetyl-N6-hydroxy-L-lysine
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2 ATP + citrate + N6-acetyl-N6-hydroxy-L-lysine + H2O
2 ADP + 2 phosphate + N2-citryl-N6-acetyl-N6-hydroxy-L-lysine
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the enzyme is involved in biosynthesis of aerobactin
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2 ATP + citrate + N6-acetyl-N6-hydroxy-L-lysine + H2O
2 ADP + 2 phosphate + N2-citryl-N6-acetyl-N6-hydroxy-L-lysine
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2 ATP + citrate + N6-acetyl-N6-hydroxy-L-lysine + H2O
2 ADP + 2 phosphate + N2-citryl-N6-acetyl-N6-hydroxy-L-lysine
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the enzyme catalyses the second of two synthase reactions to link N6-acetyl-N6-hydroxy-L-lysine and citrate in biosynthesis of aerobactin. Aerobactin is excreted by cultures of Aerobacter aerogenes 62-I and related strains when growing in an iron-deficient medium
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2 ATP + citrate + N6-acetyl-N6-hydroxy-L-lysine + H2O
2 ADP + 2 phosphate + N2-citryl-N6-acetyl-N6-hydroxy-L-lysine
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absolute requirement for ATP in aerobactin production. Other nucleoside triphosphates (UTP, CTP and GTP) are not effective in promoting aerobactin synthesis. Utilization of ATP (decrease in its concentration) is also noted when L-lysine or glycine or L-norleucine is used in the place of N6-acetyl-N6-hydroxylysine
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2 ATP + citrate + N6-acetyl-N6-hydroxy-L-lysine + H2O
2 ADP + 2 phosphate + N2-citryl-N6-acetyl-N6-hydroxy-L-lysine
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?
2 ATP + citrate + N6-acetyl-N6-hydroxy-L-lysine + H2O
2 ADP + 2 phosphate + N2-citryl-N6-acetyl-N6-hydroxy-L-lysine
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absolute requirement for ATP in aerobactin production. Other nucleoside triphosphates (UTP, CTP and GTP) are not effective in promoting aerobactin synthesis. Utilization of ATP (decrease in its concentration) is also noted when L-lysine or glycine or L-norleucine is used in the place of N6-acetyl-N6-hydroxylysine
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2 ATP + citrate + N6-acetyl-N6-hydroxy-L-lysine + H2O
2 ADP + 2 phosphate + N2-citryl-N6-acetyl-N6-hydroxy-L-lysine
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the enzyme catalyses the second of two synthase reactions to link N6-acetyl-N6-hydroxy-L-lysine and citrate in biosynthesis of aerobactin. Aerobactin is excreted by cultures of Aerobacter aerogenes 62-I and related strains when growing in an iron-deficient medium
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NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
2 ATP + citrate + N6-acetyl-N6-hydroxy-L-lysine + H2O
2 ADP + 2 phosphate + N2-citryl-N6-acetyl-N6-hydroxy-L-lysine
2 ATP + citrate + N6-acetyl-N6-hydroxy-L-lysine + H2O
2 ADP + 2 phosphate + N2-citryl-N6-acetyl-N6-hydroxy-L-lysine
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2 ATP + citrate + N6-acetyl-N6-hydroxy-L-lysine + H2O
2 ADP + 2 phosphate + N2-citryl-N6-acetyl-N6-hydroxy-L-lysine
Q47316
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2 ATP + citrate + N6-acetyl-N6-hydroxy-L-lysine + H2O
2 ADP + 2 phosphate + N2-citryl-N6-acetyl-N6-hydroxy-L-lysine
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the enzyme is involved in biosynthesis of aerobactin
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?
2 ATP + citrate + N6-acetyl-N6-hydroxy-L-lysine + H2O
2 ADP + 2 phosphate + N2-citryl-N6-acetyl-N6-hydroxy-L-lysine
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?
2 ATP + citrate + N6-acetyl-N6-hydroxy-L-lysine + H2O
2 ADP + 2 phosphate + N2-citryl-N6-acetyl-N6-hydroxy-L-lysine
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the enzyme catalyses the second of two synthase reactions to link N6-acetyl-N6-hydroxy-L-lysine and citrate in biosynthesis of aerobactin. Aerobactin is excreted by cultures of Aerobacter aerogenes 62-I and related strains when growing in an iron-deficient medium
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?
2 ATP + citrate + N6-acetyl-N6-hydroxy-L-lysine + H2O
2 ADP + 2 phosphate + N2-citryl-N6-acetyl-N6-hydroxy-L-lysine
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?
2 ATP + citrate + N6-acetyl-N6-hydroxy-L-lysine + H2O
2 ADP + 2 phosphate + N2-citryl-N6-acetyl-N6-hydroxy-L-lysine
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the enzyme catalyses the second of two synthase reactions to link N6-acetyl-N6-hydroxy-L-lysine and citrate in biosynthesis of aerobactin. Aerobactin is excreted by cultures of Aerobacter aerogenes 62-I and related strains when growing in an iron-deficient medium
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METALS and IONS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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INHIBITORS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
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LINKS TO OTHER DATABASES (specific for EC-Number 6.3.2.38)
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