Information on EC 188.8.131.52 - ubiquitin-protein ligase and Organism(s) Homo sapiens and UniProt Accession Q68DV7
for references in articles please use BRENDA:EC184.108.40.206
deleted. The ubiquitinylation process is now known to be performed by several enzymes in sequence, starting with EC 220.127.116.11 (ubiquitin-activating enzyme E1) and followed by several transfer reactions, including those of EC 18.104.22.168 (E2 ubiquitin-conjugating enzyme) and EC 22.214.171.124 (RING-type E3 ubiquitin transferase)
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MGRN-1 is one of two accessory proteins for MC signaling, it inhibits functional coupling of MC1R and MC4R to the cAMP pathway, mechanism, overview. All MGRN1 isozymes decrease agonist-induced cAMP production by as much as 50%
UbcM2 regulates the stability and transcriptional activity of the antioxidant transcription factor Nrf2 (nuclear factor E2-related factor 2). UbcM2 is involved in the restoration of redox homeostasis following oxidative stress