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Information on EC 6.3.2.19 - ubiquitin-protein ligase and Organism(s) Mus musculus and UniProt Accession P22682

for references in articles please use BRENDA:EC6.3.2.19
deleted. The ubiquitinylation process is now known to be performed by several enzymes in sequence, starting with EC 6.2.1.45 (ubiquitin-activating enzyme E1) and followed by several transfer reactions, including those of EC 2.3.2.23 (E2 ubiquitin-conjugating enzyme) and EC 2.3.2.27 (RING-type E3 ubiquitin transferase)
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GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
malfunction
metabolism
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the ubiquitin ligase Huwe1 operates upstream of the N-Myc-DLL3-Notch pathway to control neural stem cell activity and promote neurogenesis, it is part of the Huwe1-N-myc pathway
physiological function
EXPRESSION
ORGANISM
UNIPROT
LITERATURE
MURF1 shows strong postnatal up-regulation in heart
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