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Information on EC 6.3.2.17 - tetrahydrofolate synthase

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IUBMB Comments
In some bacteria, a single protein catalyses both this activity and that of EC 6.3.2.12, dihydrofolate synthase , the combined activity of which leads to the formation of the coenzyme polyglutamated tetrahydropteroate (H4PteGlun), i.e. various tetrahydrofolates (H4folate). In contrast, the activities are located on separate proteins in most eukaryotes studied to date . In Arabidopsis thaliana, this enzyme is present as distinct isoforms in the mitochondria, the cytosol and the chloroplast. Each isoform is encoded by a separate gene, a situation that is unique among eukaryotes . As the affinity of folate-dependent enzymes increases markedly with the number of glutamic residues, the tetrahydropteroyl polyglutamates are the preferred coenzymes of C1 metabolism. (reviewed in ). The enzymes from different sources (particularly eukaryotes versus prokaryotes) have different substrate specificities with regard to one-carbon substituents and the number of glutamate residues present on the tetrahydrofolates.
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The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea
Synonyms
folylpolyglutamate synthetase, mthfd1l, folylpoly-gamma-glutamate synthetase, folylpolyglutamate synthase, folypolyglutamate synthetase, fpgs1, atdfb, cfpgs, mfpgs, folylpolyglutamyl synthetase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
ATP + tetrahydropteroyl-[gamma-Glu]n + L-glutamate = ADP + phosphate + tetrahydropteroyl-[gamma-Glu]n+1
show the reaction diagram
PATHWAY SOURCE
PATHWAYS