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Disease on EC 6.3.2.10 - UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Acute Kidney Injury
Upregulation of MuRF1 and MAFbx participates to muscle wasting upon gentamicin-induced acute kidney injury.
Acute Lung Injury
A Critical Role for Muscle Ring Finger-1 in Acute Lung Injury-Associated Skeletal Muscle Wasting.
Arthritis
Eicosapentaenoic acid attenuates arthritis-induced muscle wasting acting on atrogin-1 and on myogenic regulatory factors.
Experimental arthritis inhibits the insulin-like growth factor-I axis and induces muscle wasting through cyclooxygenase-2 activation.
Ghrelin receptor agonist GHRP-2 prevents arthritis-induced increase in E3 ubiquitin-ligating enzymes MuRF1 and MAFbx gene expression in skeletal muscle.
Melanocortin-4 receptor agonist (RO27-3225) ameliorates soleus but not gastrocnemius atrophy in arthritic rats.
Bone Resorption
MURF1 deficiency suppresses unloading-induced effects on osteoblasts and osteoclasts to lead to bone loss.
Cardiomegaly
Cardiac muscle ring finger-1 increases susceptibility to heart failure in vivo.
Fenofibrate unexpectedly induces cardiac hypertrophy in mice lacking MuRF1.
Into the heart: The emerging role of the ubiquitin-proteasome system.
Metformin attenuates angiotensin II-induced cardiomyocyte hypertrophy by upregulating the MuRF1 and MAFbx pathway.
MuRF1 mono-ubiquitinates TR? to inhibit T3 induced cardiac hypertrophy in vivo.
MuRF1 Negatively Regulates Pathological Cardiac Hypertrophy Through Downregulation of Calcineurin A.
Muscle ring finger 1 and muscle ring finger 2 are necessary but functionally redundant during developmental cardiac growth and regulate E2F1-mediated gene expression in vivo.
Muscle ring finger 1 mediates cardiac atrophy in vivo.
Muscle ring finger 1, but not muscle ring finger 2, regulates cardiac hypertrophy in vivo.
Muscle ring finger protein-1 inhibits PKC{epsilon} activation and prevents cardiomyocyte hypertrophy.
Muscle RING-finger protein-1 (MuRF1) functions and cellular localization are regulated by SUMO1 post-translational modification.
Rise above: muscle ring-finger-1 (MURF1) regulation of cardiomyocyte size and energy metabolism.
Cardiomyopathy, Hypertrophic
Muscle ring finger 1 and muscle ring finger 2 are necessary but functionally redundant during developmental cardiac growth and regulate E2F1-mediated gene expression in vivo.
Myosin accumulation and striated muscle myopathy result from the loss of muscle RING finger 1 and 3.
Rare variants in genes encoding MuRF1 and MuRF2 are modifiers of hypertrophic cardiomyopathy.
Colitis
Skeletal muscle catabolism in trinitrobenzene sulfonic acid-induced murine colitis.
Diabetic Neuropathies
[Effects of electroacupuncture on skeletal muscle and blood glucose in rats with diabetic amyotrophy].
Gastrointestinal Neoplasms
Inactivation of the ubiquitin-specific protease 19 deubiquitinating enzyme protects against muscle wasting.
Heart Failure
Cardiac muscle ring finger-1 increases susceptibility to heart failure in vivo.
Heart failure increases atrogin-1 and MuRF1 gene expression in skeletal muscle with fiber type-specific atrophy.
Muscle ring finger 1 and muscle ring finger 2 are necessary but functionally redundant during developmental cardiac growth and regulate E2F1-mediated gene expression in vivo.
Muscle-specific regulation of right ventricular transcriptional responses to chronic hypoxia-induced hypertrophy by the muscle ring finger-1 (MuRF1) ubiquitin ligase in mice.
Hyperparathyroidism, Primary
The gene expression and activity of calpains and the muscle wasting-associated ubiquitin ligases, atrogin-1 and MuRF1, are not altered in patients with primary hyperparathyroidism.
Hypertension, Pulmonary
Expression of MuRF1 or MuRF2 is essential for the induction of skeletal muscle atrophy and dysfunction in a murine pulmonary hypertension model.
Muscle RING finger-1 promotes a maladaptive phenotype in chronic hypoxia-induced right ventricular remodeling.
Muscle-specific regulation of right ventricular transcriptional responses to chronic hypoxia-induced hypertrophy by the muscle ring finger-1 (MuRF1) ubiquitin ligase in mice.
Hyperthyroidism
Experimental hyperthyroidism in rats increases the expression of the ubiquitin ligases atrogin-1 and MuRF1 and stimulates multiple proteolytic pathways in skeletal muscle.
Hypertrophy, Right Ventricular
Muscle RING finger-1 promotes a maladaptive phenotype in chronic hypoxia-induced right ventricular remodeling.
Hypogonadism
Effects of a novel selective androgen receptor modulator on dexamethasone-induced and hypogonadism-induced muscle atrophy.
Infections
Pulmonary Pseudomonas aeruginosa infection induces autophagy and proteasome proteolytic pathways in skeletal muscles: effects of a pressurized whey protein-based diet in mice.
Inflammatory Bowel Diseases
Skeletal muscle catabolism in trinitrobenzene sulfonic acid-induced murine colitis.
Insulin Resistance
Fasting serum amino acids concentration is associated with insulin resistance and pro-inflammatory cytokines.
Leukemia
Preclinical Investigation of the Novel Histone Deacetylase Inhibitor AR-42 in the Treatment of Cancer-Induced Cachexia.
Lung Injury
A Critical Role for Muscle Ring Finger-1 in Acute Lung Injury-Associated Skeletal Muscle Wasting.
Lung Neoplasms
Inactivation of the ubiquitin-specific protease 19 deubiquitinating enzyme protects against muscle wasting.
Malnutrition
Fast digestive, leucine-rich, soluble milk proteins improve muscle protein anabolism, and mitochondrial function in undernourished old rats.
Melanoma
Small-Molecule Chemical Knockdown of MuRF1 in Melanoma Bearing Mice Attenuates Tumor Cachexia Associated Myopathy.
Muscular Atrophy
A CELL AUTONOMOUS ROLE FOR THE GLUCOCORTICOID RECEPTOR IN SKELETAL MUSCLE ATROPHY INDUCED BY SYSTEMIC GLUCOCORTICOID EXPOSURE.
A Critical Role for Muscle Ring Finger-1 in Acute Lung Injury-Associated Skeletal Muscle Wasting.
A new pathway encompassing calpain 3 and its newly identified substrate cardiac ankyrin repeat protein is involved in the regulation of the nuclear factor-?B pathway in skeletal muscle.
Activin A induces skeletal muscle catabolism via p38? mitogen-activated protein kinase.
ALDH2 restores exhaustive exercise-induced mitochondrial dysfunction in skeletal muscle.
Altered gene expression patterns in muscle ring finger 1 null mice during denervation- and dexamethasone-induced muscle atrophy.
Androgenic and estrogenic regulation of Atrogin-1, MuRF1 and myostatin expression in different muscle types of male mice.
Angiotensin II Induces Skeletal Muscle Atrophy by Activating TFEB-Mediated MuRF1 Expression.
Autophagy induction in atrophic muscle cells requires ULK1 activation by TRIM32 through unanchored K63-linked polyubiquitin chains.
Branched-chain amino acids reduce hindlimb suspension-induced muscle atrophy and protein levels of atrogin-1 and MuRF1 in rats.
Buyang Huanwu Tang improves denervation-dependent muscle atrophy by increasing ANGPTL4, and increases NF-?B and MURF1 levels.
C/EBP? regulates dexamethasone-induced muscle cell atrophy and expression of atrogin-1 and MURF1.
Calycosin inhibited autophagy and oxidative stress in chronic kidney disease skeletal muscle atrophy by regulating AMPK/SKP2/CARM1 signalling pathway.
Cancer cachexia.
Clenbuterol suppresses proteasomal and lysosomal proteolysis and atrophy-related genes in denervated rat soleus muscles independently of Akt.
Conditional activation of MET in differentiated skeletal muscle induces atrophy.
Conessine treatment reduces dexamethasone-induced muscle atrophy by regulating MuRF1 and atrogin-1 expression.
Conessine Treatment Reduces Dexamethasone-Induced Muscle Atrophy by Regulating MuRF1 and Atrogin-1 Expression.
Construction, Expression and Characterization of a Single Chain Variable Fragment Antibody Against Human Myostatin.
Daidzein alleviates cisplatin-induced muscle atrophy by regulating Glut4/AMPK/FoxO pathway.
DCAF8, a novel MuRF1 interaction partner, promotes muscle atrophy.
De novo ceramides synthesis is not involved in skeletal muscle atrophy induced by short-term mechanical unloading.
Deficiency of inducible nitric oxide synthase attenuates immobilization-induced skeletal muscle atrophy in mice.
Deletion of atrophy enhancing genes fails to ameliorate the phenotype in a mouse model of spinal muscular atrophy.
Delphinidin Prevents Muscle Atrophy and Upregulates miR-23a Expression.
Dependence of dexamethasone-induced Akt/FOXO1 signaling, upregulation of MAFbx, and protein catabolism upon the glucocorticoid receptor.
Developmental regulation of MURF E3 ubiquitin ligases in skeletal muscle.
Dexamethasone and BCAA Failed to Modulate Muscle Mass and mTOR Signaling in GH-Deficient Rats.
Differential gene expression of muscle-specific ubiquitin ligase MAFbx/Atrogin-1 and MuRF1 in response to immobilization-induced atrophy of slow-twitch and fast-twitch muscles.
Differential skeletal muscle gene expression after upper or lower motor neuron transection.
Doxorubicin Exposure Causes Subacute Cardiac Atrophy Dependent on the Striated Muscle-Specific Ubiquitin Ligase MuRF1.
Doxorubicin Induces Inflammatory Modulation and Metabolic Dysregulation in Diabetic Skeletal Muscle.
Effect of dietary fish oil intake on ubiquitin ligase expression during muscle atrophy induced by sciatic nerve denervation in mice.
Effect of skeletal muscle phenotype and gender on fasting-induced myokine expression in mice.
Effects of tail suspension on serum testosterone and molecular targets regulating muscle mass.
Electrical stimulation delays reinnervation in denervated rat muscle.
Evolutionary loss of foot muscle during development with characteristics of atrophy and no evidence of cell death.
Exercise training has beneficial anti-atrophy effects by inhibiting oxidative stress-induced MuRF1 upregulation in rats with diabetes.
Exogenous insulin-like growth factor 1 attenuates cisplatin-induced muscle atrophy in mice.
Expression of MuRF1 or MuRF2 is essential for the induction of skeletal muscle atrophy and dysfunction in a murine pulmonary hypertension model.
FHL1 regulates myoblast differentiation and autophagy through its interaction with LC3.
FoxO3a suppression and VPS34 activity are essential to anti-atrophic effects of leucine in skeletal muscle.
Functional overload in ground squirrel plantaris muscle fails to induce myosin isoform shifts.
GHRP-2, a GHS-R agonist, directly acts on myocytes to attenuate the dexamethasone-induced expressions of muscle-specific ubiquitin ligases, Atrogin-1 and MuRF1.
Glucocorticoid Receptor Signaling Impairs Protein Turnover Regulation in Hypoxia-Induced Muscle Atrophy in Male Mice.
Glucocorticoids increase skeletal muscle NF-?B inducing kinase (NIK): links to muscle atrophy.
HDAC4 Knockdown Alleviates Denervation-Induced Muscle Atrophy by Inhibiting Myogenin-Dependent Atrogene Activation.
Heart failure increases atrogin-1 and MuRF1 gene expression in skeletal muscle with fiber type-specific atrophy.
High CO2 levels cause skeletal muscle atrophy via AMPK, FoxO3a and muscle-specific ring finger protein1 (MuRF1).
HMGB1 release and redox regulation accompany regeneration and remodeling of skeletal muscle.
Human skeletal muscle atrophy in amyotrophic lateral sclerosis reveals a reduction in Akt and an increase in atrogin-1.
Ibandronate concomitantly blocks immobilization-induced bone and muscle atrophy.
Identification of the MuRF1 Skeletal Muscle Ubiquitylome Through Quantitative Proteomics.
Identification of the optimal dose and calpain system regulation of tetramethylpyrazine on the prevention of skeletal muscle atrophy in hindlimb unloading rats.
IGF-1 is downregulated in experimental cancer cachexia.
IKKbeta/NF-kappaB activation causes severe muscle wasting in mice.
Increased Expression of MuRF1 Is Associated with Radiation-induced Laryngeal Muscle Atrophy.
Inhibition of interleukin-6 decreases atrogene expression and ameliorates tail suspension-induced skeletal muscle atrophy.
Insulin Modulates Myogenesis and Muscle Atrophy Resulting From Skin Scald Burn in Young Male Rats.
Iron limitation promotes the atrophy of skeletal myocytes, whereas iron supplementation prevents this process in the hypoxic conditions.
Licorice flavonoid oil enhances muscle mass in KK-Ay mice.
Linalool Prevents Cisplatin Induced Muscle Atrophy by Regulating IGF-1/Akt/FoxO Pathway.
Long-term physical inactivity exacerbates hindlimb unloading-induced muscle atrophy in young rat soleus muscle.
Loquat (Eriobotrya japonica) extract prevents dexamethasone-induced muscle atrophy by inhibiting the muscle degradation pathway in Sprague Dawley rats.
Lung injury-induced skeletal muscle wasting in aged mice is linked to alterations in long chain fatty acid metabolism.
Magnesium supplementation alleviates corticosteroid-associated muscle atrophy in rats.
MicroRNA351 targeting TRAF6 alleviates dexamethasone-induced myotube atrophy.
miR-23a is decreased during muscle atrophy by a mechanism that includes calcineurin signaling and exosome-mediated export.
MiR-29ab1 Cluster Resists Muscle Atrophy Through Inhibiting MuRF1.
Mitochondrial dynamic remodeling in strenuous exercise-induced muscle and mitochondrial dysfunction: Regulatory effects of hydroxytyrosol.
Mitochondrial Dysfunction Launches Dexamethasone-Induced Skeletal Muscle Atrophy via AMPK/FOXO3 Signaling.
Modified expression of vitamin D receptor and CYP27B1 in denervation-induced muscle atrophy.
Modulation of muscle atrophy, fatigue and MLC phosphorylation by MuRF1 as indicated by hindlimb suspension studies on MuRF1-KO mice.
Molecular basis for the fold organization and sarcomeric targeting of the muscle atrogin MuRF1.
Molecular characterization of the MuRF genes in rainbow trout: Potential role in muscle degradation.
Molecular mechanisms modulating muscle mass.
Mountain ginseng inhibits skeletal muscle atrophy by decreasing muscle RING ?nger protein-1 and atrogin1 through forkhead box O3 in L6 myotubes.
mTORC1 promotes denervation-induced muscle atrophy through a mechanism involving the activation of FoxO and E3 ubiquitin ligases.
MuRF1/TRIM63, Master Regulator of Muscle Mass.
Muscle atrophy and hypertrophy signaling in patients with chronic obstructive pulmonary disease.
Muscle proteolytic system modulation through the effect of taurine on mice bearing muscular atrophy.
Muscle RING-finger protein-1 (MuRF1) functions and cellular localization are regulated by SUMO1 post-translational modification.
Muscle Sparing in Muscle RING Finger 1 Null Mice: Response to Synthetic Glucocorticoids.
Muscle-specific MicroRNA1 (miR1) Targets Heat Shock Protein 70 (HSP70) during Dexamethasone-mediated Atrophy.
Myostatin Augments Muscle-Specific Ring Finger Protein-1 Expression Through an NF-kB Independent Mechanism in SMAD3 Null Muscle.
MYOSTATIN REDUCES AKT/TORC1/p70S6K SIGNALING, INHIBITING MYOBLAST DIFFERENTIATION AND MYOTUBE SIZE.
NF-kappaB but not FoxO sites in the MuRF1 promoter are required for transcriptional activation in disuse muscle atrophy.
Noninvasive Imaging of In Vivo MuRF1 Expression during Muscle Atrophy.
P38?-MAPK Signaling Inhibition Attenuates Soleus Atrophy during Early Stages of Muscle Unloading.
Paracrine effects of IGF-1 overexpression on the functional decline due to skeletal muscle disuse: molecular and functional evaluation in hindlimb unloaded MLC/mIgf-1 transgenic mice.
Peroxynitrite induces degradation of myosin heavy chain via p38 MAPK and muscle-specific E3 ubiquitin ligases in C2 skeletal myotubes.
Physical inactivity induces the atrophy of skeletal muscle of rats through activating AMPK/FoxO3 signal pathway.
PI3 Kinase Regulation of Skeletal Muscle Hypertrophy and Atrophy.
PPARdelta agonism induces a change in fuel metabolism and activation of an atrophy programme, but does not impair mitochondrial function in rat skeletal muscle.
Protective effect of branched chain amino acids on hindlimb suspension-induced muscle atrophy in growing rats.
Proteomic and bioinformatic analysis of differentially expressed proteins in denervated skeletal muscle.
Pyropia yezoensis peptide PYP1?5 protects against dexamethasone?induced muscle atrophy through the downregulation of atrogin1/MAFbx and MuRF1 in mouse C2C12 myotubes.
Regulation of nicotinic acetylcholine receptor turnover by MuRF1 connects muscle activity to endo/lysosomal and atrophy pathways.
Resistance exercise, muscle loading/unloading and the control of muscle mass.
Resveratrol attenuates skeletal muscle atrophy induced by chronic kidney disease via MuRF1 signaling pathway.
Sepsis and glucocorticoids downregulate the expression of the nuclear cofactor PGC-1beta in skeletal muscle.
Short-term feed deprivation rapidly induces the protein degradation pathway in skeletal muscles of young mice.
Signaling pathways perturbing muscle mass.
Skeletal Muscle Alterations Are Exacerbated in Heart Failure With Reduced Compared With Preserved Ejection Fraction: Mediated by Circulating Cytokines?
Skeletal Muscle Anti-Atrophic Effects of Leucine Involve Myostatin Inhibition.
Skeletal muscle atrophy and the E3 ubiquitin ligases MuRF1 and MAFbx/atrogin-1.
Skeletal muscle catabolism in trinitrobenzene sulfonic acid-induced murine colitis.
Skeletal muscle hypertrophy and atrophy signaling pathways.
Skeletal muscle in MuRF1 null mice is not spared in low-gravity conditions, indicating atrophy proceeds by unique mechanisms in space.
Smad2/3 Proteins Are Required for Immobilization-induced Skeletal Muscle Atrophy.
Small-Molecule Chemical Knockdown of MuRF1 in Melanoma Bearing Mice Attenuates Tumor Cachexia Associated Myopathy.
Small-molecule inhibition of MuRF1 attenuates skeletal muscle atrophy and dysfunction in cardiac cachexia.
Suppression of atrogin-1 and MuRF1 prevents dexamethasone-induced atrophy of cultured myotubes.
Targeting the Ubiquitin E3 Ligase MuRF1 to Inhibit Muscle Atrophy.
The E3 ubiquitin ligase TRIM62 and inflammation-induced skeletal muscle atrophy.
The effect of vitamin D on sarcopenia depends on the level of physical activity in older adults.
The glucocorticoid receptor and FOXO1 synergistically activate the skeletal muscle atrophy-associated MuRF1 gene.
The preventive effect of ?-carotene on denervation-induced soleus muscle atrophy in mice.
The role and regulation of MAFbx/atrogin-1 and MuRF1 in skeletal muscle atrophy.
The Sympathetic Nervous System Regulates Skeletal Muscle Motor Innervation and Acetylcholine Receptor Stability.
TNF Receptor-Associated Factor 6 Mediates TNF?-Induced Skeletal Muscle Atrophy in Mice During Aging.
TRAF6 inhibition rescues dexamethasone-induced muscle atrophy.
Transcriptional activation of muscle atrophy promotes cardiac muscle remodeling during mammalian hibernation.
Transnasal sphenopalatine ganglion blockade for acute facial pain: a prospective randomized case-control study.
Trichostatin A, a histone deacetylase inhibitor, modulates unloaded-induced skeletal muscle atrophy.
Tumor necrosis factor-like weak inducer of apoptosis regulates quadriceps muscle atrophy and fiber-type alteration in a rat model of chronic obstructive pulmonary disease.
Ubiquitin ligases MuRF1 and MAFbx in human skeletal muscle atrophy.
Ubiquitin-protein ligases in muscle wasting.
Ubiquitylation by Trim32 causes coupled loss of desmin, Z-bands, and thin filaments in muscle atrophy.
Unexpected regulation pattern of the IKK?/NF-?B/MuRF1 pathway with remarkable muscle plasticity in the Daurian ground squirrel (Spermophilus dauricus).
Upregulation of MuRF1 and MAFbx participates to muscle wasting upon gentamicin-induced acute kidney injury.
WNK1 regulates skeletal muscle cell hypertrophy by modulating the nuclear localization and transcriptional activity of FOXO4.
[Effect of Ligustrazine on expressions of FoXO3a, MAFbx, and MuRF1 in denervated skeletal].
[MAFbx and MuRF1 mRNA expression and its relationship with muscular contractility following free muscle transfer]
[The changes of p-Akt/MuRF1/FoxO1 proteins expressions in the conditions of training and immobilization in rats' gastrocnemius muscle].
Muscular Diseases
Effects of a novel selective androgen receptor modulator on dexamethasone-induced and hypogonadism-induced muscle atrophy.
Expression of MuRF1 or MuRF2 is essential for the induction of skeletal muscle atrophy and dysfunction in a murine pulmonary hypertension model.
Muscle Fiber Atrophy and Regeneration Coexist in Collagen VI-Deficient Human Muscle: Role of Calpain-3 and Nuclear Factor-?B Signaling.
Muscle RING-finger protein-1 (MuRF1) functions and cellular localization are regulated by SUMO1 post-translational modification.
Myosin accumulation and striated muscle myopathy result from the loss of muscle RING finger 1 and 3.
New cardiac and skeletal protein aggregate myopathy associated with combined MuRF1 and MuRF3 mutations.
Regulation of Glucose Metabolism by MuRF1 and Treatment of Myopathy in Diabetic Mice with Small Molecules Targeting MuRF1.
Small-Molecule Chemical Knockdown of MuRF1 in Melanoma Bearing Mice Attenuates Tumor Cachexia Associated Myopathy.
Small-molecule-mediated chemical knock-down of MuRF1/MuRF2 and attenuation of diaphragm dysfunction in chronic heart failure.
Muscular Disorders, Atrophic
Changes in REDD1, REDD2, and atrogene mRNA expression are prevented in skeletal muscle fixed in a stretched position during hindlimb immobilization.
Hsp27 inhibits IKKbeta-induced NF-kappaB activity and skeletal muscle atrophy.
NF-kappaB but not FoxO sites in the MuRF1 promoter are required for transcriptional activation in disuse muscle atrophy.
[Research advance on signaling pathways and protein metabolism for skeletal muscle disuse atrophy].
Myocardial Infarction
Depressed expression of MuRF1 and MAFbx in areas remote of recent myocardial infarction: a mechanism contributing to myocardial remodeling?
Neoplasms
Activation of the SDF1/CXCR4 pathway retards muscle atrophy during cancer cachexia.
Caloric restriction is associated with preservation of muscle strength in experimental cancer cachexia.
CALPAIN activity is increased in skeletal muscle from gastric cancer patients with no or minimal weight loss.
Cryptotanshinone prevents muscle wasting in CT26-induced cancer cachexia through inhibiting STAT3 signaling pathway.
Effect of dietary fish oil intake on ubiquitin ligase expression during muscle atrophy induced by sciatic nerve denervation in mice.
Experimental arthritis inhibits the insulin-like growth factor-I axis and induces muscle wasting through cyclooxygenase-2 activation.
Gastric cancer does not affect the expression of atrophy-related genes in human skeletal muscle.
Ghrelin receptor agonist GHRP-2 prevents arthritis-induced increase in E3 ubiquitin-ligating enzymes MuRF1 and MAFbx gene expression in skeletal muscle.
Imperatorin alleviates cancer cachexia and prevents muscle wasting via directly inhibiting STAT3.
Inhibition of FoxO transcriptional activity prevents muscle fiber atrophy during cachexia and induces hypertrophy.
Juzentaihoto Suppresses Muscle Atrophy and Decreased Motor Function in SAMP8 Mice.
MG132-mediated inhibition of the ubiquitin-proteasome pathway ameliorates cancer cachexia.
Molecular and cellular adaptations to exercise training in skeletal muscle from cancer patients treated with chemotherapy.
MuRF1/TRIM63, Master Regulator of Muscle Mass.
Preclinical Investigation of Alpinetin in the Treatment of Cancer-Induced Cachexia via Activating PPAR?.
Small-Molecule Chemical Knockdown of MuRF1 in Melanoma Bearing Mice Attenuates Tumor Cachexia Associated Myopathy.
TAK-242, a specific inhibitor of Toll-like receptor 4 signalling, prevents endotoxemia-induced skeletal muscle wasting in mice.
The rat model of COPD skeletal muscle dysfunction induced by progressive cigarette smoke exposure: a pilot study.
Obesity
Deterioration of mitochondrial function in the human intercostal muscles differs among individuals with sarcopenia, obesity, and sarcopenic obesity.
Osteoporosis
1?,25(OH)2D3 downregulates gene expression levels of muscle ubiquitin ligases MAFbx and MuRF1 in human myotubes.
Pancreatic Neoplasms
TRIF is a key inflammatory mediator of acute sickness behavior and cancer cachexia.
Peritonitis
Hormone, cytokine, and nutritional regulation of sepsis-induced increases in atrogin-1 and MuRF1 in skeletal muscle.
Pulmonary Disease, Chronic Obstructive
Atrophy and hypertrophy signalling of the quadriceps and diaphragm in COPD.
Involvement of the FoxO1/MuRF1/Atrogin-1 Signaling Pathway in the Oxidative Stress-Induced Atrophy of Cultured Chronic Obstructive Pulmonary Disease Myotubes.
Muscle atrophy and hypertrophy signaling in patients with chronic obstructive pulmonary disease.
Tumor necrosis factor-like weak inducer of apoptosis regulates quadriceps muscle atrophy and fiber-type alteration in a rat model of chronic obstructive pulmonary disease.
Renal Insufficiency
MuRF1/TRIM63, Master Regulator of Muscle Mass.
Renal Insufficiency, Chronic
Resveratrol attenuates skeletal muscle atrophy induced by chronic kidney disease via MuRF1 signaling pathway.
Reperfusion Injury
MuRF1 activity is present in cardiac mitochondria and regulates reactive oxygen species production in vivo.
Muscle RING finger-1 attenuates IGF-I-dependent cardiomyocyte hypertrophy by inhibiting JNK signaling.
Sarcopenia
Atrogin-1/MAFbx and MuRF1 are downregulated in aging-related loss of skeletal muscle.
Atrophy-related ubiquitin ligases, atrogin-1 and MuRF1 are up-regulated in aged rat Tibialis Anterior muscle.
Deterioration of mitochondrial function in the human intercostal muscles differs among individuals with sarcopenia, obesity, and sarcopenic obesity.
Effects of ageing on expression of the muscle-specific E3 ubiquitin ligases and Akt-dependent regulation of Foxo transcription factors in skeletal muscle.
Molecular analyses provide insight into mechanisms underlying sarcopenia and myofibre denervation in old skeletal muscles of mice.
Molecular mechanisms in aging and current strategies to counteract sarcopenia.
Sciatic Neuropathy
A CELL AUTONOMOUS ROLE FOR THE GLUCOCORTICOID RECEPTOR IN SKELETAL MUSCLE ATROPHY INDUCED BY SYSTEMIC GLUCOCORTICOID EXPOSURE.
Sepsis
Inhibition of FoxO transcriptional activity prevents muscle fiber atrophy during cachexia and induces hypertrophy.
INHIBITION OF GSK-3? ACTIVITY WITH LITHIUM IN VITRO ATTENUATES SEPSIS-INDUCED CHANGES IN MUSCLE PROTEIN TURNOVER.
Marginal dietary zinc deprivation augments sepsis-induced alterations in skeletal muscle TNF-? but not protein synthesis.
MuRF1/TRIM63, Master Regulator of Muscle Mass.
PPAR?/? regulates glucocorticoid- and sepsis-induced FOXO1 activation and muscle wasting.
Sepsis and glucocorticoids downregulate the expression of the nuclear cofactor PGC-1beta in skeletal muscle.
Sepsis increases the expression and activity of the transcription factor Forkhead Box O 1 (FOXO1) in skeletal muscle by a glucocorticoid-dependent mechanism.
Sepsis upregulates the gene expression of multiple ubiquitin ligases in skeletal muscle.
Temporally Distinct Regulation of Pathways Contributing to Cardiac Proteostasis During the Acute and Recovery Phases of Sepsis.
Spinal Cord Injuries
(-)-Epicatechin reduces muscle waste after complete spinal cord transection in a murine model: role of ubiquitin-proteasome system.
Starvation
Ibandronate concomitantly blocks immobilization-induced bone and muscle atrophy.
Muscle RING-finger protein-1 (MuRF1) as a connector of muscle energy metabolism and protein synthesis.
p38 MAPK Participates in Muscle-Specific RING Finger 1-Mediated Atrophy in Cast-Immobilized Rat Gastrocnemius Muscle.
Post-transcriptional regulation of autophagy in C2C12 myotubes following starvation and nutrient restoration.
Proteolytic systems' expression during myogenesis and transcriptional regulation by amino acids in gilthead sea bream cultured muscle cells.
Ubiquitin E3 ligase atrogin-1 (Fbox-32) in Atlantic salmon (Salmo salar): sequence analysis, genomic structure and modulation of expression.
Stomach Neoplasms
Gastric cancer does not affect the expression of atrophy-related genes in human skeletal muscle.
udp-n-acetylmuramoyl-tripeptide-d-alanyl-d-alanine ligase deficiency
MuRF1 deficiency prevents age-related fat weight gain, possibly through accumulation of PDK4 in skeletal muscle mitochondria in older mice.
MURF1 deficiency suppresses unloading-induced effects on osteoblasts and osteoclasts to lead to bone loss.
Vitamin D Deficiency
The effect of vitamin D on sarcopenia depends on the level of physical activity in older adults.
Wasting Syndrome
Recent progress in elucidating signalling proteolytic pathways in muscle wasting: Potential clinical implications.