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Disease on EC 6.3.2.1 - pantoate-beta-alanine ligase (AMP-forming)

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
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Altered Metabolic Flexibility in Inherited Metabolic Diseases of Mitochondrial Fatty Acid Metabolism.
5'-nucleotidase deficiency
Inborn errors of purine metabolism: clinical update and therapies.
Pyrimidine nucleotides impair phosphoribosylpyrophosphate (PRPP) synthetase subunit aggregation by sequestering magnesium. A mechanism for the decreased PRPP synthetase activity in hereditary erythrocyte pyrimidine 5'-nucleotidase deficiency.
6,7-dihydropteridine reductase deficiency
Differential diagnosis of tetrahydrobiopterin deficiency.
Pterin metabolism in normal subjects and hyperphenylalaninaemic patients.
[Trial of indirect screening of tetrahydrobiopterin deficiency]
6-phosphofructokinase deficiency
Activities of glycogen synthetase and UDPG-pyrophosphorylase in muscle of a patient with a new type of muscle glycogenosis caused by phosphofructokinase deficiency.
Abetalipoproteinemia
HARP syndrome is allelic with pantothenate kinase-associated neurodegeneration.
Neuroacanthocytosis syndromes.
Neuroacanthocytosis.
Neurologic phenotypes associated with acanthocytosis.
Abscess
Transcriptome analysis of Enterococcus faecalis during mammalian infection shows cells undergo adaptation and exist in a stringent response state.
Acidosis
Respiratory chain defect of myocardial mitochondria in idiopathic dilated cardiomyopathy of Doberman pinscher dogs.
[Glutathion-synthetase deficiency with 5-oxoprolinuria. Two new cases and a review of the literature (author's transl)]
Acquired Immunodeficiency Syndrome
Elevated levels of interferon-induced 2'-5' oligoadenylate synthetase in generalized persistent lymphadenopathy and the acquired immunodeficiency syndrome.
Interferon-induced 2'-5' oligoadenylate synthetase during interferon-alpha therapy in homosexual men with Kaposi's sarcoma: marked deficiency in biochemical response to interferon in patients with acquired immunodeficiency syndrome.
Acute Lung Injury
Cyclooxygenase and lipoxygenase inhibition by BW-755C reduces acrolein smoke-induced acute lung injury.
Novel insights into phosgene-induced acute lung injury in rats: role of dysregulated cardiopulmonary reflexes and nitric oxide in lung edema pathogenesis.
Role of poly-(ADP-ribose) synthetase in lipopolysaccharide-induced vascular failure and acute lung injury in pigs.
adenine phosphoribosyltransferase deficiency
Use of intact erythrocytes in the diagnosis of inherited purine and pyrimidine disorders.
Adenocarcinoma
Cancer-Specific Production of N-Acetylaspartate via NAT8L Overexpression in Non-Small Cell Lung Cancer and Its Potential as a Circulating Biomarker.
Carbamoyl phosphate synthetase (glutamine-hydrolyzing): increased activity in cancer cells.
Cell type-specific differences in metabolic activation of N-nitrosodiethylamine by human lung cancer cell lines.
Fatty acid synthetase from a mouse mammary adenocarcinoma.
Insensitivity to interferon of two subclones of human endometrial carcinoma cell line, HEC-1.
Resistance of cyclooxygenase-2 expressing pancreatic ductal adenocarcinoma cells against ?? T cell cytotoxicity.
Simplified methods for obtaining purified oocysts from mice and for growing Cryptosporidium parvum in vitro.
Tissue specificity for the effect of estrogen on lipogenic activity in male and female rats.
[The selective toxicity of 5-hydroxymethyldeoxyuridine for the cells of human adenocarcinoma of the large intestine]
Adenocarcinoma of Lung
Comparison of pyrimidine nucleotide synthetic enzymes involved in 5-fluorouracil metabolism between human adenocarcinomas and squamous cell carcinomas.
Nivolumab-induced anti-aminoacyl-tRNA synthetase antibody-positive polymyositis complicated by interstitial pneumonia in a patient with lung adenocarcinoma.
Adenoma
Molecular Diagnostics in the Neoplasms of the Pancreas, Liver, Gallbladder, and Extrahepatic Biliary Tract: 2018 Update.
Adenoma, Liver Cell
[Immunophenotypic classification of 3 cases of hepatocellular adenoma. Differential diagnosis with focal nodular hyperplasia].
Adenomatous Polyposis Coli
Predictive value of nuclear beta-catenin expression for the occurrence of distant metastases in rectal cancer.
Adenomatous Polyps
Aberration of poly(adenosine diphosphate-ribose) metabolism in human colon adenomatous polyps and cancers.
Adrenoleukodystrophy
Beta-oxidation of very-long-chain fatty acids and their coenzyme A derivatives by human skin fibroblasts.
Direct demonstration that the deficient oxidation of very long chain fatty acids in X-linked adrenoleukodystrophy is due to an impaired ability of peroxisomes to activate very long chain fatty acids.
Effects of sodium 2-[5-(4-chlorophenyl)pentyl]-oxirane-2-carboxylate (POCA) on fatty acid oxidation in fibroblasts from patients with peroxisomal diseases.
Role of very-long-chain acyl-coenzyme A synthetase in X-linked adrenoleukodystrophy.
AIDS-Related Complex
Elevated levels of interferon-induced 2'-5' oligoadenylate synthetase in generalized persistent lymphadenopathy and the acquired immunodeficiency syndrome.
Albuminuria
Hypertensive patients exhibit an altered metabolism. A specific metabolite signature in urine is able to predict albuminuria progression.
Picotamide, a dual TXB synthetase inhibitor and TXB receptor antagonist, reduces exercise-induced albuminuria in microalbuminuric patients with NIDDM.
Alopecia
Comparative evaluation between two nutritional supplements in the improvement of telogen effluvium.
Comparing the Effects of Zinc Sulfate, Calcium Pantothenate, Their Combination and Minoxidil Solution Regimens on Controlling Hair Loss in Women: A Randomized Controlled Trial.
[Evaluation of vitamin B6 and calcium pantothenate effectiveness on hair growth from clinical and trichographic aspects for treatment of diffuse alopecia in women]
Alzheimer Disease
Absence of the 40-kDa form of (2'-5')oligoadenylate synthetase and its corresponding mRNA from skin fibroblasts derived from Alzheimer disease patients.
Comparative study of 2',5'-oligoadenylate (2-5A) synthetase in control and Alzheimer's disease (AD) cells.
Neuronal plasticity and astrocytic reaction in Down syndrome and Alzheimer disease.
Neuropareidolia: diagnostic clues apropos of visual illusions.
New Perspectives in Iron Chelation Therapy for the Treatment of Neurodegenerative Diseases.
Role of iron in neurodegenerative disorders.
Vitamin B5 (d-pantothenic acid) localizes in myelinated structures of the rat brain: Potential role for cerebral vitamin B5 stores in local myelin homeostasis.
[Effect of electroacupuncture on the expression of insulin signal pathway related proteins in hippocampus in mice with Alzheimer's disease].
amino-acid n-acetyltransferase deficiency
Improving long term outcomes in urea cycle disorders-report from the Urea Cycle Disorders Consortium.
Amyotrophic Lateral Sclerosis
Copper, Iron, and Manganese Toxicity in Neuropsychiatric Conditions.
Anaphylaxis
An inhibitor of poly(adenosine 5'-diphosphoribose) synthetase, 3-aminobenzamide, does not improve cardiovascular depression, bronchospasm, or survival associated with systemic anaphylaxis in rabbits in vivo.
Bronchial anaphylaxis in actively sensitized Sprague Dawley rats: studies on mediators involved.
Nitric oxide, perioxynitrite and poly(ADP-ribose) synthetase in anaphylactic shock.
Anemia
-Glutamyl-cysteine synthetase deficiency. A cause of hereditary hemolytic anemia.
First report of co-morbidity of pantothenate kinase-associated neurodegeneration and three types of chronic hemolytic anemias.
Heme synthesis in hereditary hemolytic anemias: decreased delta-aminolevulinic acid synthetase in hemoglobin Köln disease.
[Glutathion-synthetase deficiency with 5-oxoprolinuria. Two new cases and a review of the literature (author's transl)]
Anemia, Hemolytic
-Glutamyl-cysteine synthetase deficiency. A cause of hereditary hemolytic anemia.
Patients with genetic defects in the gamma-glutamyl cycle.
Anemia, Hemolytic, Congenital
-Glutamyl-cysteine synthetase deficiency. A cause of hereditary hemolytic anemia.
Anemia, Hypochromic
Capacity for chlorophyll synthesis in heat-bleached 70S ribosome-deficient rye leaves.
Mode of Action of the Toxin from Pseudomonas phaseolicola: I. Toxin Specificity, Chlorosis, and Ornithine Accumulation.
The Synechococcus strain PCC 7942 glnN product (glutamine synthetase III) helps recovery from prolonged nitrogen chlorosis.
Anemia, Megaloblastic
Hereditary Orotic Aciduria and the Excretion of Orotidine.
Anemia, Refractory
Fusion of TEL/ETV6 to a novel ACS2 in myelodysplastic syndrome and acute myelogenous leukemia with t(5;12)(q31;p13).
Anemia, Sickle Cell
First report of co-morbidity of pantothenate kinase-associated neurodegeneration and three types of chronic hemolytic anemias.
Heme synthesis in hereditary hemolytic anemias: decreased delta-aminolevulinic acid synthetase in hemoglobin Köln disease.
Anemia, Sideroblastic
A case of primary acquired sideroblastic anemia with deficient -aminolevulinic acid synthetase activity in bone marrow erythroblasts.
Haem synthesis in sideroblastic anaemia.
Identification of an arginine452 to histidine substitution in the erythroid 5-aminolaevulinate synthetase gene in a large pedigree with X-linked hereditary sideroblastic anaemia.
Linkage analysis of a large pedigree with hereditary sideroblastic anaemia.
Angina, Unstable
DTTX30, a combined thromboxane receptor antagonist and thromboxane synthetase inhibitor, prevents coronary thrombosis in anesthetized dogs.
arginase deficiency
Early liver transplantation in neonatal-onset and moderate urea cycle disorders may lead to normal neurodevelopment.
Efficacy and safety of i.v. sodium benzoate in urea cycle disorders: a multicentre retrospective study.
Improving long term outcomes in urea cycle disorders-report from the Urea Cycle Disorders Consortium.
arginine-trna ligase deficiency
Phenotypes and genotypes of mitochondrial aminoacyl-tRNA synthetase deficiencies from a single neurometabolic clinic.
argininosuccinate lyase deficiency
Improving long term outcomes in urea cycle disorders-report from the Urea Cycle Disorders Consortium.
argininosuccinate synthase deficiency
Improving long term outcomes in urea cycle disorders-report from the Urea Cycle Disorders Consortium.
Argininosuccinic Aciduria
Improving long term outcomes in urea cycle disorders-report from the Urea Cycle Disorders Consortium.
Urea Cycle Disorders: A Neuroimaging Pattern Approach Using Diffusion and FLAIR MRI.
Arteriosclerosis
LOWER URINARY TRACT SYMPTOMS AND ERECTILE DYSFUNCTION.
Arthralgia
Oxygen-Dependent Patient with Antisynthetase Syndrome Associated Interstitial Lung Disease Responds Promptly to Rituximab with Rapid Pulmonary Function Improvement.
Arthritis
A new approach to the classification of idiopathic inflammatory myopathy: myositis-specific autoantibodies define useful homogeneous patient groups.
Antisynthetase syndrome associated with sarcoidosis.
Antisynthetase syndrome presenting as rheumatoid-like polyarthritis.
Antisynthetase syndrome: An under-recognized cause of interstitial lung disease.
Attenuation of the progression of adjuvant-induced arthritis by 3-aminobenzamide treatment.
Clinical and immunogenetic features of patients with autoantibodies to asparaginyl-transfer RNA synthetase.
Clinical manifestations in patients with antibody to PL-12 antigen (alanyl-tRNA synthetase).
Clinicoserological features of antisynthetase syndrome (ASyS)-associated interstitial lung disease presenting to respiratory services: comparison with idiopathic pulmonary fibrosis and ASyS diagnosed in rheumatology services.
Development of antisynthetase syndrome in a patient with rheumatoid arthritis.
Impaired intrinsic chiral inversion activity of ibuprofen in rats with adjuvant-induced arthritis.
[Antisynthetase syndromes].
[Clinical and pathological findings of patients with interstitial lung disease associated with antisynthetase]
[The effect of calcium pantothenate on the adrenal cortex of patients with rheumatoid polyarthritis treated with corticosteroids]
Arthritis, Rheumatoid
A case of interstitial lung disease with anti-EJ and anti-CCP antibodies preceding rheumatoid arthritis.
Herpes simplex virus and the rheumatic diseases.
Higher PGD2 production by synovial mast cells from rheumatoid arthritis patients compared with osteoarthritis patients via miR-199a-3p/prostaglandin synthetase 2 axis.
The Association of Anti-Aminoacyl-Transfer Ribonucleic Acid Synthetase Antibodies in Patients With Rheumatoid Arthritis and Interstitial Lung Disease.
Therapeutic advantages of the addition of calcium pantothenate to salicylates in the oral treatment of rheumatoid arthritis.
Asthma
Effect of OKY-046, a new thromboxane A2 synthetase inhibitor, on experimental asthma in guinea pigs.
Effect of synthetase inhibitors and receptor antagonists in antigen-induced contraction of human lung parenchyma.
Effect of thromboxane A2 synthetase inhibitor, OKY-046, on sputum in chronic bronchitis and diffuse panbronchiolitis.
Effects of cysteinyl-leukotriene receptor antagonist, thromboxane A2 receptor antagonist, and thromboxane A2 synthetase inhibitor on antigen-induced bronchoconstriction in patients with asthma.
Effects of inhibition of thromboxane A2 synthesis in aspirin-induced asthma.
Glutathione ethyl ester supplementation prevents airway hyper-responsiveness in mice.
Human bronchial epithelium controls TH2 responses by TH1-induced, nitric oxide-mediated STAT5 dephosphorylation: implications for the pathogenesis of asthma.
Ineffectiveness of a four week treatment with the thromboxane synthetase inhibitor, imidazole salycilate, in reducing airway hyperresponsiveness to methacholine in asthmatics.
Leukotriene modifiers: novel therapeutic opportunities in asthma.
Raised interferon ?, type 3 interferon and interferon stimulated genes - evidence of innate immune activation in neutrophilic asthma.
The modulatory effect of antigen- and PAF-induced asthmatic reaction by aerosol administration of OKY-046 in guinea pigs.
[Cytochemical indicators of lymphocytes after inhalation of riboflavin-nucleotide and calcium pantothenate in children with bronchial asthma]
[Decurarization with calcium pantothenate after operations on pulmonary patients with bronchial asthma]
[In Process Citation]
[Thromboxane A2 synthetase inhibitor in asthma therapy]
Asthma, Aspirin-Induced
Effects of inhibition of thromboxane A2 synthesis in aspirin-induced asthma.
Asthma, Exercise-Induced
Effect of OKY-046 (thromboxane A2 synthetase inhibitor) on exercise-induced asthma.
Astrocytoma
Participation of poly(ADP-ribose) synthetase in the process of norepinephrine-induced inhibition of major histocompatibility complex class II antigen expression in human astrocytoma cells.
Ataxia
Deep brain stimulation as a mode of treatment of early onset pantothenate kinase-associated neurodegeneration.
Potential Treatment of Retinal Diseases with Iron Chelators.
Subthalamic Nuclei Stimulation in Patients With Pantothenate Kinase-Associated Neurodegeneration (PKAN).
Atherosclerosis
Edaravone, a radical scavenger, may enhance or produce antiproliferative effects of fluvastatin, amlodipine, ozagrel, GF109203X and Y27632 on cultured basilar artery smooth muscle cells.
Fatty acid synthesis in aorta. Isolation of fatty acid synthetase from chicken aorta.
Lipids and cholesterol esterifying enzyme changes by Anna Pavala Sindhooram therapy in experimental rat hyperlipaemia.
Role of inflammatory cytokines in genesis and treatment of atherosclerosis.
The combined use of prostaglandin I2 analogue (OP-2507) and thromboxane A2 synthetase inhibitor (OKY-046) strongly inhibits atherosclerosis of aortic allografts in rats.
[Statins: possibly more than just lowering of the lipid level]
Autoimmune Diseases
An N,N-Bis(benzimidazolylpicolinoyl)piperazine (BT-11): A Novel Lanthionine Synthetase C-Like 2-Based Therapeutic for Inflammatory Bowel Disease.
Clinical evaluation of anti-aminoacyl tRNA synthetase antibodies in Japanese patients with dermatomyositis.
Correlation of Antisynthetase Antibody Levels with Disease Course in a Patient with Interstitial Lung Disease and Elevated Muscle Enzymes.
Autoimmune Pancreatitis
A case with overlapping features of IgG4-related autoimmune pancreatitis, Sjögren's syndrome and anti-aminoacyl-tRNA synthetase syndrome.
Avitaminosis
Drugs producing vitamin deficiencies.
Azoospermia
Deprivation of pantothenic acid elicits a movement disorder and azoospermia in a mouse model of pantothenate kinase-associated neurodegeneration.
Bartter Syndrome
Normal prostaglandinuria E2 in Gitelman's syndrome, the hypocalciuric variant of Bartter's syndrome.
Basal Ganglia Diseases
Magnetic resonance imaging pattern recognition in childhood bilateral basal ganglia disorders.
Neurodegeneration with brain iron accumulation.
Behcet Syndrome
Oligo-2',5'-adenylate synthetase activity in peripheral blood mononuclear leukocytes in various diseases.
[Investigations of interferon and oligo-2',5'-adenylate systems in endogenous uveitis]
beta-Thalassemia
Heme synthesis in hereditary hemolytic anemias: decreased delta-aminolevulinic acid synthetase in hemoglobin Köln disease.
Impaired erythrocyte NAD synthesis: a metabolic abnormality in thalassemia.
biotin-[propionyl-coa-carboxylase (atp-hydrolysing)] ligase deficiency
Deficiency of biotinyl-AMP synthetase activity in fibroblasts of patients with holocarboxylase synthetase deficiency.
[Three congenital metabolic diseases in the Faeroe Islands. Incidence, clinical and molecular genetic characteristics of Faeroese children with glycogen storage disease type IIIA, carnitine transporter deficiency and holocarboxylase synthetase deficiency]
Biotinidase Deficiency
Nutritional therapy for selected inborn errors of metabolism.
Bone Diseases
Pharmaceutical inhibition of glycogen synthetase kinase-3? reduces multiple myeloma-induced bone disease in a novel murine plasmacytoma xenograft model.
Bone Resorption
Bimodal actions of reactive oxygen species in the differentiation and bone-resorbing functions of osteoclasts.
Brain Diseases
A comparison of interferon levels with leukocyte (2'-5') oligoadenylate synthetase activity as markers of viral encephalopathies.
Carbamyl phosphate synthetase 1 deficiency: a destructive encephalopathy.
Copper, Iron, and Manganese Toxicity in Neuropsychiatric Conditions.
Deficient activity of alanyl-tRNA synthetase underlies an autosomal recessive syndrome of progressive microcephaly, hypomyelination, and epileptic encephalopathy.
Magnetic resonance imaging pattern recognition in childhood bilateral basal ganglia disorders.
Management of status dystonicus: our experience and review of the literature.
Mitochondrial phenylalanyl-tRNA synthetase mutations underlie fatal infantile Alpers encephalopathy.
Pantothenate kinase-associated neurodegeneration in two Chinese children: identification of a novel PANK2 gene mutation.
Prospective cohort study for identification of underlying genetic causes in neonatal encephalopathy using whole-exome sequencing.
Syndromes of neurodegeneration with brain iron accumulation.
VARS2-linked mitochondrial encephalopathy: two case reports enlarging the clinical phenotype.
Brain Edema
[Cerebral edema with hyperammonemia in valpromide poisoning. Manifestation in an adult, of a partial deficit in type I carbamylphosphate synthetase]
Brain Injuries
3-Aminobenzamide, a poly (ADP-ribose) synthetase inhibitor, attenuates the acute inflammatory responses and brain injury in experimental Escherichia coli meningitis in the newborn piglet.
[Cerebrospinal fluid as informative source of the brain]
Brain Injuries, Traumatic
Transplantation of N -acetyl aspartyl-glutamate synthetase-activated neural stem cells after experimental traumatic brain injury significantly improves neurological recovery.
Brain Ischemia
Neuroprotective effects of inhibiting poly(ADP-ribose) synthetase on focal cerebral ischemia in rats.
Brain Neoplasms
Quantification of prostaglandin D synthetase in cerebrospinal fluid: a potential marker for brain tumor.
Targeting brain tumor cAMP: the case for sex-specific therapeutics.
Breast Neoplasms
2', 5' oligo (A) synthetase levels in interferon-sensitive or resistant breast cancer cells.
Analysis of indoleamine 2-3 dioxygenase (IDO1) expression in breast cancer tissue by immunohistochemistry.
Combined the SMAC mimetic and BCL2 inhibitor sensitizes neoadjuvant chemotherapy by targeting necrosome complexes in tyrosine aminoacyl-tRNA synthase-positive breast cancer.
Differential effect of forms A and B of human progesterone receptor on estradiol-dependent transcription.
Effect of branched-chain fatty acids on fatty acid biosynthesis of human breast cancer cells.
Effects of progestins and menstrual cycle on fatty acid synthetase and progesterone receptor in human mammary glands.
Expression of the progestin-induced fatty acid synthetase in benign mastopathies and breast cancer as measured by RNA in situ hybridization.
Fatty acid synthetase and its mRNA are induced by progestins in breast cancer cells.
Her2/neu small interfering RNA delivered in culture by a streptavidin nanoparticle.
Hormone-regulated genes (pS2, PIP, FAS) in breast cancer and nontumoral mammary tissue.
Induction of 2'-5' oligoadenylate synthetase and activation of ribonuclease in tamoxifen treated human breast cancer cell lines.
Progestin increases gene transcription and messenger ribonucleic acid stability of fatty acid synthetase in breast cancer cells.
Progestin-induced fatty acid synthetase in breast cancer. From molecular biology to clinical applications.
Prospective study of fatty acid synthetase (FAS) expression in breast cancer and progression of disease.
Regulation of fatty acid synthetase ribonucleic acid in the human endometrium during the menstrual cycle.
The anti-progestin RU486 stabilizes the progestin-induced fatty acid synthetase mRNA but does not stimulate its transcription.
White button mushroom phytochemicals inhibit aromatase activity and breast cancer cell proliferation.
[An immunohistochemical study of aromatase, estrogen 4-hydroxylase and fatty acid synthetase in breast cancer tissues from BRCA1 mutation carriers]
[Effect of up-regulation of S-AdoMet synthetase on taxol-induced apoptosis in human breast cancer cells]
[Molecular-biological markers as prognostic factors in breast cancer of I-IIA stage]
Bronchial Spasm
An inhibitor of poly(adenosine 5'-diphosphoribose) synthetase, 3-aminobenzamide, does not improve cardiovascular depression, bronchospasm, or survival associated with systemic anaphylaxis in rabbits in vivo.
Effects of 1-[3-(4-benzhydryl-1-piperazinyl)propyl]-3- (1H-imidazol-1-ylmethyl)-1H-indole-6-carboxylic acid with thromboxane A2 synthetase inhibitory and H1-blocking activities on anaphylactic bronchospasm.
Bronchiolitis
Inflammatory myopathy, bronchiolitis obliterans/organizing pneumonia, and anti-Jo-1 antibodies--an interesting association.
Burkitt Lymphoma
Protein kinase C is required for induction of 2',5'-oligoadenylate synthetases.
Candidiasis
Antifungal effects of the nonlinear pharmacokinetics of cilofungin, a 1,3-beta-glucan synthetase inhibitor, during continuous and intermittent intravenous infusions in treatment of experimental disseminated candidiasis.
carbamoyl-phosphate synthase (ammonia) deficiency
Early liver transplantation in neonatal-onset and moderate urea cycle disorders may lead to normal neurodevelopment.
Novel human pathological mutations. Gene symbol: CPS1. Disease: carbamoyl phosphate synthetase I deficiency.
Carbamoyl-Phosphate Synthase I Deficiency Disease
Continuous venovenous haemofiltration in the acute treatment of inborn errors of metabolism.
Metabolic stroke in carbamyl phosphate synthetase deficiency.
Novel human pathological mutations. Gene symbol: CPS1. Disease: carbamoyl phosphate synthetase I deficiency.
Carcinogenesis
A novel human tRNA-dihydrouridine synthase involved in pulmonary carcinogenesis.
Association of promoter polymorphism -765G>C in the PTGS2 gene with malignant melanoma in Italian patients and its correlation to gene expression in dermal fibroblasts.
Beta-catenin mutations are frequent in hepatocellular carcinomas but absent in adenomas induced by diethylnitrosamine in B6C3F1 mice.
Cyclin D1 over-expression correlates with beta-catenin activation, but not with H-ras mutations, and phosphorylation of Akt, GSK3 beta and ERK1/2 in mouse hepatic carcinogenesis.
DNA damage induced by peroxynitrite: subsequent biological effects.
Do NSAIDs exert their colon cancer chemoprevention activities through the inhibition of mucosal prostaglandin synthetase?
Fatty acid synthetase and its mRNA are induced by progestins in breast cancer cells.
Resistance of cyclooxygenase-2 expressing pancreatic ductal adenocarcinoma cells against ?? T cell cytotoxicity.
Studies of carcinogenesis by avian sarcoma viruses. II. Virus-induced increase in hyaluronic acid synthetase in chicken fibroblasts.
[Mechanism of carcinogenesis. VII. Biosynthesis of carbamyl phosphate synthetase I in vivo and in vitro in hepatocellular carcinoma and liver of rats fed with diethylnitrosamine]
Carcinoma
Cancer-Specific Production of N-Acetylaspartate via NAT8L Overexpression in Non-Small Cell Lung Cancer and Its Potential as a Circulating Biomarker.
Combined therapy with cisplatin and interferon alpha-2b (INTRON-A) in patients with penile carcinoma. Analysis of 2'5' oligo (A) synthetase and circulating interferon.
Comparison of pyrimidine nucleotide synthetic enzymes involved in 5-fluorouracil metabolism between human adenocarcinomas and squamous cell carcinomas.
Development of a chemoresistant orthotopic human nonsmall cell lung carcinoma model in nude mice: analyses of tumor heterogenity in relation to the immunohistochemical levels of expression of cyclooxygenase-2, ornithine decarboxylase, lung-related resistance protein, prostaglandin E synthetase, and glutathione-S-transferase-alpha (GST)-alpha, GST-mu, and GST-pi.
FLUORINATED PYRIMIDINES. XXV. THE INHIBITION OF THYMIDYLATE SYNTHETASE FROM EHRLICH ASCITES CARCINOMA CELLS BY PYRIMIDINE ANALOGS.
Glucosylceramide synthetase inhibitor, D-threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol exhibits a novel decarcinogenic activity against Shope carcinoma cells.
Heme regulation in mouse mammary carcinoma and liver of tumor bearing mice--I. Effect of allyl-isopropylacetamide and veronal on delta-aminolevulinate synthetase, cytochrome P-450 and cytochrome oxidase.
Histochemical studies of glycogen metabolizing enzymes in normal and abnormal human cervical epithelium.
Hormonal and immunological regulation of 2', 5'-oligoadenylate synthetase activity in human peripheral blood mononuclear cells.
Hormone dependency of carcinoma of the human endometrium. Effect of progesterone on glycogen metabolism in the carcinoma tissue.
Inactivation by acivicin of carbamoyl-phosphate synthetase II of human colon carcinoma.
Initial steps in pyrimidine synthesis in Ehrlich ascites carcinoma in vitro. II. The synthesis of carbamyl phosphate by a soluble, glutamine-dependent carbamyl phosphate synthetase.
Monitoring of interferon treatment in patients with renal cell carcinoma and bladder carcinoma by oligo-A synthetase assay and determination of immunological parameters.
Mouse mammary carcinoma porphobilinogenase and hydroxymethylbilane synthetase.
Proliferation-linked increase in phosphoribosylformylglycinamidine synthetase activity (EC 6.3.5.3).
Purine enzymology of human colon carcinomas.
Study of 2'5' oligo (A) synthetase in patients with metastatic renal cell carcinoma.
The effects of pH and inhibitors upon the catalytic activity of the dihydroorotase of multienzymatic protein pyr1-3 from mouse Ehrlich ascites carcinoma.
The modification of ferroptosis and abnormal lipometabolism through overexpression and knockdown of potential prognostic biomarker perilipin2 in gastric carcinoma.
Using Q-RT-PCR to measure cyclin D1, TS, TP, DPD, and Her-2/neu as predictors for response, survival, and recurrence in patients with esophageal squamous cell carcinoma following radiochemotherapy.
[Mechanism of carcinogenesis. VII. Biosynthesis of carbamyl phosphate synthetase I in vivo and in vitro in hepatocellular carcinoma and liver of rats fed with diethylnitrosamine]
Carcinoma in Situ
Histochemical studies of glycogen metabolizing enzymes in normal and abnormal human cervical epithelium.
Carcinoma, Ehrlich Tumor
5-Phosphoribosyl pyrophosphate synthetase from Ehrlich ascites tumor cells.
DNA fragmentation and NAD depletion. Their relation to the turnover of endogenous mono(ADP-ribosyl) and poly(ADP-ribosyl) proteins.
Induction of 2',5'oligo (A) synthetase in animals bearing Ehrlich ascites tumor cells.
Inhibition of the phosphoribosyl-formylglycineamidine synthetase of Ehrlich ascites tumor cells by glutamine analogues.
Interferon, double-stranded RNA, and RNA degradation. Isolation of homogeneous pppA(2'p5'A)n-1 synthetase from Ehrlich ascites tumor cells.
Interferons, double-stranded RNA, and RNA degradation. Isolation and characterization of homogeneous human (2'-5')(a)n synthetase.
Purification and properties of phosphoribosyl-formylglycineamidine synthetase of ehrlich ascites tumor cells.
Studies on the activities of some methyltransferases in the livers and tumor cells from tumor-bearing mice.
Studies with pure mouse Ehrlich ascites tumor interferons alpha and beta: patterns of induction of (2'-5') (A)n synthetase and of a double-stranded RNA-dependent protein kinase in mouse cells and human cells.
Synthesis of (2'-5')(A)n from ATP. Characteristics of the reaction catalyzed by (2'-5')(A)n synthetase purified from mouse Ehrlich ascites tumor cells treated with interferon.
Carcinoma, Embryonal
Action of murine gamma (immune)interferon on beta (fibroblast)-interferon resistant L 1210 and embryonal carcinoma cells.
Carcinoma, Hepatocellular
3-Aminobenzamide inhibits poly(ADP ribose) synthetase activity and induces phosphoenolpyruvate carboxykinase (GTP) in H4IIE hepatoma cells.
?-Glutamylcysteine synthetase (?-GCS) as a target for overcoming chemo- and radio-resistance of human hepatocellular carcinoma cells.
Activities of enzymes of lipid metabolism in Morris hepatoma 7800 C1 cells.
Activities of key gluconeogenic enzymes and glycogen synthase in rat and human livers, hepatomas, and hepatoma cell cultures.
Characterization of cystathionine synthase as a selectable, liver-specific trait in rat hepatomas.
Differences in total mitochondrial proteins and proteins synthesized by mitochondria from rat liver and Morris hepatomas 9618A, 5123C, and 5123tc.
Disparity in the effects of two N-methyl nicotinamides on poly(ADP-ribose) synthetase and macromolecular synthesis in hepatomas.
Enhancement of glutathione and g-glutamylcysteine synthetase, the rate limiting enzyme of glutathione synthesis, by chemoprotective plant-derived food and beverage components in the human hepatoma cell line HepG2.
Glycogen synthesis and glycogen synthetase in rat ascites hepatomas of low and high glycogen content.
Glycogen synthesis and I to D conversion of glycogen synthetase in ascites hepatoma cells.
Glycogen synthetase of rat skeletal muscle and hepatomas and its comparison with the enzyme of rat liver.
Guanosine-5'-phosphate synthetase and guanosine-5'-phosphate kinase in rat hepatomas and kidney tumors.
In vivo inactivation by acivicin of carbamoyl-phosphate synthetase II in rat hepatoma.
In vivo inactivation of formylglycinamidine ribonucleotide synthetase in rat hepatoma.
Increased 5-phospho-alpha-D-ribose-1-diphosphate synthetase (ribosephosphate pyrophosphokinase, EC 2.7.6.1) activity in rat hepatomas.
Increased carbamoyl-phosphate synthetase II concentration in rat hepatomas: immunological evidence.
Mechanisms of receptor-mediated transmembrane communication.
Nucleotide interconversions. IV. Activities of deoxycytidylate deaminase and thymidylate synthetase in normal rat liver and hepatomas.
Proliferation-linked increase in phosphoribosylformylglycinamidine synthetase activity (EC 6.3.5.3).
Proportional activities of glycerol kinase and glycerol 3-phosphate dehydrogenase in rat hepatomas.
Regulation and expression of carbamyl phosphate synthetase I mRNA in developing rat liver and Morris hepatoma 5123D.
Regulatory properties and behavior of activity of carbamoyl phosphate synthetase II (glutamine-hydrolyzing) in normal and proliferating tissues.
Studies on the biological functions of CPS1 in AFB1 induced hepatocarcinogenesis.
Substrate and hormone regulation of palmitoyl-CoA synthetase in 7800 C1 Morris hepatoma cells and cultured rat hepatocytes.
Synergistic Activation of the Nrf2-Signaling Pathway by Glyceollins under Oxidative Stress Induced by Glutathione Depletion.
Thymidylate synthetase activity in the Novikoff hepatoma.
[Immunophenotypic classification of 3 cases of hepatocellular adenoma. Differential diagnosis with focal nodular hyperplasia].
[Mechanism of carcinogenesis. VII. Biosynthesis of carbamyl phosphate synthetase I in vivo and in vitro in hepatocellular carcinoma and liver of rats fed with diethylnitrosamine]
[Multivariate analysis of aminoacyl-tRNA synthetase activities of liver and hepatomas (author's transl)]
[The coenzyme A and the activity of coenzyme A synthetase in hepatoma in the white rat]
Carcinoma, Lewis Lung
Proliferation-linked increase in phosphoribosylformylglycinamidine synthetase activity (EC 6.3.5.3).
Carcinoma, Non-Small-Cell Lung
IARS2 silencing induces non-small cell lung cancer cells proliferation inhibition, cell cycle arrest and promotes cell apoptosis.
Investigation of myositis and scleroderma specific autoantibodies in patients with lung cancer.
Carcinoma, Renal Cell
Hormonal and immunological regulation of 2', 5'-oligoadenylate synthetase activity in human peripheral blood mononuclear cells.
In vivo and in vitro induction of (2'-5') oligoadenylate synthetase by human interferons in leukocytes from healthy donors and patients with renal cancer and hairy cell leukemia.
Monitoring of interferon treatment in patients with renal cell carcinoma and bladder carcinoma by oligo-A synthetase assay and determination of immunological parameters.
Study of 2'5' oligo (A) synthetase in patients with metastatic renal cell carcinoma.
Carcinoma, Squamous Cell
Cancer-Specific Production of N-Acetylaspartate via NAT8L Overexpression in Non-Small Cell Lung Cancer and Its Potential as a Circulating Biomarker.
Comparison of pyrimidine nucleotide synthetic enzymes involved in 5-fluorouracil metabolism between human adenocarcinomas and squamous cell carcinomas.
Cardiomyopathies
Exercise Training Reverses Lipotoxicity-induced Cardiomyopathy by Inhibiting HMGCS2.
Macrophages modulate cardiac function in lipotoxic cardiomyopathy.
Structural modeling of tissue-specific mitochondrial alanyl-tRNA synthetase (AARS2) defects predicts differential effects on aminoacylation.
Cardiotoxicity
A synopsis of research in cardiac apoptosis and its application to congestive heart failure.
Cardiovascular Diseases
The regulatory roles of aminoacyl-tRNA synthetase in cardiovascular disease.
Carotid Artery Thrombosis
The role of thromboxane (TX) A2 in rabbit arterial thrombosis induced by endothelial damage.
Cataract
Recessive Mutation in a Nuclear-Encoded Mitochondrial tRNA Synthetase Associated With Infantile Cataract, Congenital Neurotrophic Keratitis, and Orbital Myopathy.
Cerebral Hemorrhage
A comparison of interferon levels with leukocyte (2'-5') oligoadenylate synthetase activity as markers of viral encephalopathies.
Activating PPAR? Increases NQO1 and ?-GCS Expression via Nrf2 in Thrombin-activated Microglia.
Beneficial effects of acute intravenous ibuprofen on neurologic recovery of head-injured mice: comparison of cyclooxygenase inhibition with inhibition of thromboxane A2 synthetase or 5-lipoxygenase.
Long non-coding RNA H19 protects against intracerebral hemorrhage injuries via regulating microRNA-106b-5p/acyl-CoA synthetase long chain family member 4 axis.
Cerebral Infarction
Pharmacological studies on the TXA2 synthetase inhibitor (E)-3-[p-(1H-imidazol-1-ylmethyl)phenyl]-2-propenoic acid (OKY-046).
Thromboxane synthetase inhibition in acute focal cerebral ischemia in cats.
Cerebral Palsy
Electrophysiological assessment of the effect of intrathecal baclofen in dystonic children.
Magnetic resonance imaging pattern recognition in childhood bilateral basal ganglia disorders.
Chagas Disease
Assessing gene expression during pathogenesis: Use of qRT-PCR to follow toxin production in the entomopathogenic fungus Beauveria bassiana during infection and immune response of the insect host Triatoma infestans.
Charcot-Marie-Tooth Disease
A novel AARS mutation in a family with dominant myeloneuropathy.
Crystallization and preliminary X-ray analysis of a native human tRNA synthetase whose allelic variants are associated with Charcot-Marie-Tooth disease.
Deficient activity of alanyl-tRNA synthetase underlies an autosomal recessive syndrome of progressive microcephaly, hypomyelination, and epileptic encephalopathy.
Chikungunya Fever
Association of Oligoadenylate Synthetase Gene Cluster and DC-SIGN (CD209) Gene Polymorphisms with Clinical Symptoms in Chikungunya Virus Infection.
Cholestasis
Bile acids modulate the interferon signalling pathway.
Effect of cholestasis and bile acids on interferon-induced 2',5'-adenylate synthetase and NK cell activities.
Sphingosine 1-phosphate receptor-1 specific agonist SEW2871 ameliorates ANIT-induced dysregulation of bile acid homeostasis in mice plasma and liver.
Choline Deficiency
Regulation by dietary choline of hepatic fatty acid synthetase in the rat.
Chorea
Huntington's disease look-alikes.
Neuromodulation for neurodegenerative conditions.
Choriocarcinoma
Characterization of a sodium-dependent vitamin transporter mediating the uptake of pantothenate, biotin and lipoate in human placental choriocarcinoma cells.
Human placental Na+-dependent multivitamin transporter. Cloning, functional expression, gene structure, and chromosomal localization.
Choroidal Neovascularization
Blockade of nitric-oxide synthase reduces choroidal neovascularization.
Chronic Periodontitis
Biochemical alterations in inflammatory periodontal diseases I. Poly (ADP-ribose) synthetase activity in gingiva and gingival fibroblasts from humans with periodontitis.
Citrullinemia
Allosteric and catalytic functions of the PPi-binding motif in the ATP sulfurylase-GTPase system.
Animal model of human disease. Citrullinemia (argininosuccinate synthetase deficiency).
Citrullinemia: prenatal diagnosis of an affected fetus.
First report of carglumic acid in a patient with citrullinemia type 1 (argininosuccinate synthetase deficiency).
Improving long term outcomes in urea cycle disorders-report from the Urea Cycle Disorders Consortium.
Neonatal citrullinemia associated with cutaneous manifestations and arginine deficiency.
Retroviral-mediated gene therapy for the treatment of citrullinemia. Transfer and expression of argininosuccinate synthetase in human hematopoietic cells.
Skin, hair and nail changes in a case of citrullinemia with late manifestation.
The first successful live birth following preimplantation genetic diagnosis using PCR for type 1 citrullinemia.
Urea Cycle Disorders: A Neuroimaging Pattern Approach Using Diffusion and FLAIR MRI.
[A case of citrullinemia associated with isolated ACTH deficiency, rapidly developing coma]
Coinfection
Three Gene Signature for Predicting the Development of Hepatocellular Carcinoma in Chronically Infected Hepatitis C Virus Patients.
Colic
Treatment of renal colic by prostaglandin synthetase inhibitors and avafortan (analgesic antispasmodic).
Colitis
Blockade of Poly(ADP-ribose) synthetase inhibits neutrophil recruitment, oxidant generation, and mucosal injury in murine colitis.
Faecal diversion for Crohn's colitis: a model to study the role of the faecal stream in the inflammatory process.
Glucosamine synthetase activity of the colonic mucosa in membranous colitis.
Host nuclear factor erythroid 2-related factor-2 defense system determines the outcome of dextran sulfate sodium-induced colitis in mice.
Mucosal glucosamine synthetase activity in inflammatory bowel disease.
Colitis, Ulcerative
(2'-5') oligo adenylate synthetase activity in leucocytes of patients with inflammatory bowel disease.
(2'-5')Oligoadenylate synthetase activity in intestinal mononuclear and epithelial cells of inflammatory bowel disease patients.
Glucosamine synthetase activity of the colonic mucosa in ulcerative colitis and Crohn's disease.
Mucosal glucosamine synthetase activity in inflammatory bowel disease.
Nonclinical Toxicology and Toxicokinetic Profile of an Oral Lanthionine Synthetase C-Like 2 (LANCL2) Agonist, BT-11.
Proceedings: Glucosamine synthetase activity in the colonic mucosa in ulcerative colitis and Crohn's disease.
The Safety, Tolerability, and Pharmacokinetics Profile of BT-11, an Oral, Gut-Restricted Lanthionine Synthetase C-Like 2 Agonist Investigational New Drug for Inflammatory Bowel Disease: A Randomized, Double-Blind, Placebo-Controlled Phase I Clinical Trial.
Collagen Diseases
[Serum 2-5 oligoadenylate synthetase activity in infectious diseases and collagen diseases in childhood]
Colonic Neoplasms
Do NSAIDs exert their colon cancer chemoprevention activities through the inhibition of mucosal prostaglandin synthetase?
Elevated methionine-tRNA synthetase activity in human colon cancer.
Elevated vitamin levels in colon adenocarcinoma as compared with metastatic liver adenocarcinoma from colon primary and normal adjacent tissue.
Pharmacokinetic and biochemical studies on acivicin in phase I clinical trials.
The cinnamon-derived dietary factor cinnamic aldehyde activates the Nrf2-dependent antioxidant response in human epithelial colon cells.
Colorectal Neoplasms
Expression of AIMP1, 2 and 3, the scaffolds for the multi-tRNA synthetase complex, is downregulated in gastric and colorectal cancer.
Frameshift Mutation of MARS Gene Encoding an Aminoacyl-tRNA Synthetase in Gastric and Colorectal Carcinomas with Microsatellite Instability.
Novel mRNA isoforms and mutations of uridine monophosphate synthetase and 5-fluorouracil resistance in colorectal cancer.
Prevalence and association of pks+ Escherichia coli with colorectal cancer in patients at the University Malaya Medical Centre, Malaysia.
[Raltitrexed-induced skin reaction]
Coma
Brain glutamine by MRS in a patient with urea cycle disorder and coma.
ComA-dependent transcriptional activation of lichenysin A synthetase promoter in Bacillus subtilis cells.
Effect of inulin on efficient production and regulatory biosynthesis of bacillomycin D in Bacillus subtilis fmbJ.
Lichenysin production is improved in codY null Bacillus licheniformis by addition of precursor amino acids.
Liver transplantation for citrullinaemia improves intellectual function.
Communicable Diseases
[Serum 2-5 oligoadenylate synthetase activity in infectious diseases and collagen diseases in childhood]
Confusion
CNS Vasculitis in Anti-Synthetase Syndrome.
Structural organization of high-Mr mammalian aminoacyl-tRNA synthetases. Comparison of multi-enzyme complexes from different sources.
Congenital Microtia
Mass Spectrometric Characterization of Metabolites in Ear Cartilage: Congenital Microtia and Normal Auricle.
Connective Tissue Diseases
2',5'-oligoadenylate synthetase induction in lymphocytes of patients with connective tissue diseases.
Anti-transfer RNA antibodies in two patients with pulmonary fibrosis, Raynaud's phenomenon and polyarthritis.
Antisynthetase syndrome: An under-recognized cause of interstitial lung disease.
Clinicoserological features of antisynthetase syndrome (ASyS)-associated interstitial lung disease presenting to respiratory services: comparison with idiopathic pulmonary fibrosis and ASyS diagnosed in rheumatology services.
Herpes simplex virus and the rheumatic diseases.
Pathogenic aspects of dermatomyositis, polymyositis and overlap myositis.
Coproporphyria, Hereditary
Hepatic delta-aminolaevulinic acid synthetase in an attack of hereditary coproporphyria and during remission.
Corneal Diseases
[Animal experiment studies on the problem of treating corneal lesions]
Corneal Injuries
Half mustard (CEES) induced damage to rabbit cornea: attenuating effect of taurine-pyruvate-alpha-ketoglutarate-pantothenate mixture.
Corneal Neovascularization
Potential involvement of nitric oxide synthase but not inducible nitric oxide synthase in the development of experimental corneal neovascularization.
Coronary Occlusion
Inhibition of thromboxane A2 synthetase failed to limit myocardial infarct size in a rabbit ischemia-reperfusion model.
Myocardial salvage by a novel thromboxane A2 synthetase inhibitor in a canine coronary occlusion-reperfusion model.
Coronary Thrombosis
DTTX30, a combined thromboxane receptor antagonist and thromboxane synthetase inhibitor, prevents coronary thrombosis in anesthetized dogs.
Effects of Y-20811, a thromboxane A2 synthetase inhibitor, on experimentally induced coronary thrombosis in anesthetized dogs.
Corticobasal Degeneration
Neuropathology and pathogenesis of extrapyramidal movement disorders: a critical update-I. Hypokinetic-rigid movement disorders.
Cough
Identification of viral infections in pregnancy by assay of (2'-5')-oligo-isoadenylate synthetase.
Thromboxane A2 synthetase inhibition suppresses cough induced by angiotensin converting enzyme inhibitors.
Craniocerebral Trauma
[Experimental substantiation of the method of pharmaco-metabolic brain protection against hypoxia in severe craniocerebral injury]
Crohn Disease
(2'-5') oligo adenylate synthetase activity in leucocytes of patients with inflammatory bowel disease.
(2'-5')Oligoadenylate synthetase activity in intestinal mononuclear and epithelial cells of inflammatory bowel disease patients.
Exploratory Studies With BT-11: A Proposed Orally Active Therapeutic for Crohn's Disease.
Glucosamine synthetase activity of the colonic mucosa in ulcerative colitis and Crohn's disease.
Mucosal glucosamine synthetase activity in inflammatory bowel disease.
Nonclinical Toxicology and Toxicokinetic Profile of an Oral Lanthionine Synthetase C-Like 2 (LANCL2) Agonist, BT-11.
Proceedings: Glucosamine synthetase activity in the colonic mucosa in ulcerative colitis and Crohn's disease.
The Safety, Tolerability, and Pharmacokinetics Profile of BT-11, an Oral, Gut-Restricted Lanthionine Synthetase C-Like 2 Agonist Investigational New Drug for Inflammatory Bowel Disease: A Randomized, Double-Blind, Placebo-Controlled Phase I Clinical Trial.
Cryptosporidiosis
Spontaneous Selection of Cryptosporidium Drug Resistance in a Calf Model of Infection.
Cystic Fibrosis
Orthotopic liver transplantation in a patient with carbamyl phosphate synthetase deficiency and cystic fibrosis.
Cysts
Echinocandin treatment of pneumocystis pneumonia in rodent models depletes cysts leaving trophic burdens that cannot transmit the infection.
Hyphal tip growth in Phytophthora. Gradient distribution and ultrahistochemistry of enzymes.
Deafness
Expanding the phenotype of PRPS1 syndromes in females: neuropathy, hearing loss and retinopathy.
Inherited superactivity of phosphoribosylpyrophosphate synthetase: association of uric acid overproduction and sensorineural deafness.
Magnetic resonance imaging pattern recognition in childhood bilateral basal ganglia disorders.
Dehydration
A novel Maize homeodomain-leucine zipper (HD-Zip) I gene, Zmhdz10, positively regulates drought and salt tolerance in both rice and Arabidopsis.
Cloning and characterization of a salt stress-inducible small GTPase gene from the model grass species Lolium temulentum.
Effect of ploidy levels on the activities of Delta(1)-pyrroline-5-carboxylate synthetase, superoxide dismutase and peroxidase in Cenchrus species grown under water stress.
Formation of an aminovinyl-cysteine residue in thioviridamides occurs through a path independent of known lanthionine synthetase activity.
Heterologous Biosynthesis, Modifications and Structural Characterization of Ruminococcin-A, a Lanthipeptide From the Gut Bacterium Ruminococcus gnavus E1, in Escherichia coli.
Identification of proteins regulated by cross-talk between drought and hormone pathways in Arabidopsis wild-type and auxin-insensitive mutants, axr1 and axr2.
Mechanistic investigations of the dehydration reaction of lacticin 481 synthetase using site-directed mutagenesis.
Mechanistic studies of Ser/Thr dehydration catalyzed by a member of the LanL lanthionine synthetase family.
Mutants of the zinc ligands of lacticin 481 synthetase retain dehydration activity but have impaired cyclization activity.
On the substrate specificity of dehydration by lacticin 481 synthetase.
Substrate Recognition by the Class II Lanthipeptide Synthetase HalM2.
The importance of the leader sequence for directing lanthionine formation in lacticin 481.
The non-enzymatic specific amino-acylation of transfer RNA at high pressure.
Dementia
Magnetic resonance imaging in pantothenate kinase-2-associated neurodegeneration.
Neuromodulation for neurodegenerative conditions.
Neuropathology and pathogenesis of extrapyramidal movement disorders: a critical update-I. Hypokinetic-rigid movement disorders.
Sleep in genetically confirmed pantothenate kinase-associated neurodegeneration: a video-polysomnographic study.
Dengue
Glycogen synthetase kinase 3 inhibition drives MIC-A/B to promote cytokine production by human natural killer cells in Dengue virus type 2 infection.
Polymorphisms in the oligoadenylate synthetase gene cluster and its association with clinical outcomes of dengue virus infection.
Dental Caries
NagR Differentially Regulates the Expression of the glmS and nagAB Genes Required for Amino Sugar Metabolism by Streptococcus mutans.
Dermatitis
Calcium pantothenate is present in cosmetics and may cause allergic contact dermatitis.
Dermatitis, Allergic Contact
Calcium pantothenate is present in cosmetics and may cause allergic contact dermatitis.
Dermatomyositis
A retrospective cohort study in Chinese patients with adult polymyositis and dermatomyositis: risk of comorbidities and subclassification using machine learning.
Analysis of dermatomyositis-specific autoantibodies and clinical characteristics in Japanese patients.
Anti-aminoacyl tRNA Synthetase Antibody-Positive Clinically Amyopathic Dermatomyositis.
Anti-Ro52 autoantibodies are associated with interstitial lung disease and more severe disease in patients with juvenile myositis.
Clinical and immunogenetic features of patients with autoantibodies to asparaginyl-transfer RNA synthetase.
Clinical evaluation of anti-aminoacyl tRNA synthetase antibodies in Japanese patients with dermatomyositis.
Clinical manifestations of skin, lung and muscle diseases in dermatomyositis positive for anti-aminoacyl tRNA synthetase antibodies.
Clinical significance and new detection system of autoantibodies in myositis with interstitial lung disease.
Comparison of long-term prognosis and relapse of dermatomyositis complicated with interstitial pneumonia according to autoantibodies: anti-aminoacyl tRNA synthetase antibodies versus anti-melanoma differentiation-associated gene 5 antibody.
Correlation of Antisynthetase Antibody Levels with Disease Course in a Patient with Interstitial Lung Disease and Elevated Muscle Enzymes.
Distinct clinical and histological features in dermatomyositis with anti-aminoacyl-tRNA synthetase antibodies.
Genome-wide association study identifies HLA 8.1 ancestral haplotype alleles as major genetic risk factors for myositis phenotypes.
Inflammatory myopathy, bronchiolitis obliterans/organizing pneumonia, and anti-Jo-1 antibodies--an interesting association.
Macromolecular creatine kinase Type 1 in a patient with anti-aminoacyl-tRNA synthetase autoantibody-related dermatomyositis.
Plasma homocysteine levels are positively associated with interstitial lung disease in dermatomyositis patients with anti-aminoacyl-tRNA synthetase antibody.
Potential of Krebs von den Lungen-6 as a predictor of relapse in interstitial pneumonia with anti-aminoacyl tRNA synthetase antibodies-positive dermatomyositis.
Reliability and clinical utility of Enzyme-linked immunosorbent assay for detection of anti-aminoacyl-tRNA synthetase antibody.
The comparison of nailfold videocapillaroscopy findings between anti-melanoma differentiation-associated gene 5 antibody and anti-aminoacyl tRNA synthetase antibody in patients with dermatomyositis complicated by interstitial lung disease.
Treatment of idiopathic inflammatory myositis associated interstitial lung disease: A systematic review and meta-analysis.
Two cases with autoantibodies to small ubiquitin-like modifier activating enzyme: A potential unique subset of dermatomyositis-associated interstitial lung disease.
[Recent findings in dermatomyositis-specific autoantibodies].
Diabetes Insipidus, Nephrogenic
Hydrochlorothiazide-amiloride in the treatment of congenital nephrogenic diabetes insipidus.
Diabetes Mellitus
Amelioration of diabetes mellitus in partially depancreatized rats by poly(ADP-ribose) synthetase inhibitors. Evidence of islet B-cell regeneration.
Autoantibodies against aminoacyl-tRNA synthetase: novel diagnostic marker for type 1 diabetes mellitus.
Decreased expression of TNFRSF12A in thyroid gland cancer predicts poor prognosis: A study based on TCGA data.
Induction of islet B-cell regeneration in partially pancreatectomized rats by poly(ADP-ribose) synthetase inhibitors.
Low intakes of carotene, vitamin?B2 , pantothenate and calcium predict cognitive decline among elderly patients with diabetes mellitus: The Japanese Elderly Diabetes Intervention Trial.
Muscle glycogen and glycogen synthetase in normal subjects and in patients with diabetes mellitus. Effect of intravenous glucose and insulin administration.
Muscle glycogen synthetase in patients with diabetes mellitus. Basal values, effect of glycogen depletion by exercise, and effect of treatment.
Role of poly(ADP-ribose) synthetase in inflammation and ischaemia-reperfusion.
The Reg gene family and Reg proteins: with special attention to the regeneration of pancreatic beta-cells.
Vascular endothelium dysfunction: a conservative target in metabolic disorders.
Diabetes Mellitus, Experimental
Tissue concentrations of water-soluble vitamins in normal and diabetic rats.
[The effect of a water-soluble vitamins on the activity of some enzymes in diabetes.]
Diabetes Mellitus, Type 1
Autoantibodies against aminoacyl-tRNA synthetase: novel diagnostic marker for type 1 diabetes mellitus.
No evidence for association of OAS1 with type 1 diabetes in unaffected siblings or type 1 diabetic cases.
Diabetes Mellitus, Type 2
AMPK in the small intestine in normal and pathophysiological conditions.
Effect of acute thromboxane A2 inhibition on the renal hemodynamics in a spontaneously non-insulin-dependent diabetic rat, Otsuka Long-Evans Tokushima Fatty rat.
Evidence that the mitochondrial leucyl tRNA synthetase (LARS2) gene represents a novel type 2 diabetes susceptibility gene.
Molecular modeling of lanthionine synthetase component C-like protein 2: a potential target for the discovery of novel type 2 diabetes prophylactics and therapeutics.
Pathogenesis of obesity by food restriction in OLETF rats-increased intestinal monoacylglycerol acyltransferase activities may be a crucial factor.
Picotamide, a dual TXB synthetase inhibitor and TXB receptor antagonist, reduces exercise-induced albuminuria in microalbuminuric patients with NIDDM.
Diabetic Nephropathies
Evaluation of associations between single nucleotide polymorphisms in the FRMD3 and CARS genes and diabetic nephropathy in a Kuwaiti population.
UPLC-MS-based urine nontargeted metabolic profiling identifies dysregulation of pantothenate and CoA biosynthesis pathway in diabetic kidney disease.
Diphtheria
Studies on Corynebacterium diphtheriae. V. The attitude of diphtheria bacillus to some growth factors (calcium pantothenate, glutamic acid and tryptophane).
Down Syndrome
Increased activity of oligo-2',5'-adenylate synthetase in Down's syndrome and epilepsy.
Interferon induction of (2'-5') oligoisoadenylate synthetase in diploid and trisomy 21 human fibroblasts: relation to dosage of the interferon receptor gene (IRFC).
Neuronal plasticity and astrocytic reaction in Down syndrome and Alzheimer disease.
Pantothenate kinase-associated neurodegeneration (PKAN) in a child with Down syndrome. A case report and follow-up with MRI.
Drug Resistant Epilepsy
Novel Compound Heterozygous Mutations Expand the Recognized Phenotypes of FARS2-Linked Disease.
Ductus Arteriosus, Patent
Efficacy of paracetamol for the treatment of patent ductus arteriosus in preterm neonates.
Duodenal Ulcer
Attenuation of cysteamine-induced duodenal ulcer with Cochinchina momordica seed extract through inhibiting cytoplasmic phospholipase A2/5-lipoxygenase and activating ?-glutamylcysteine synthetase.
CHRONIC DUODENAL ULCERS IN PANTOTHENATE DEFICIENT MICE.
Dysarthria
Metabolic consequences of mitochondrial coenzyme A deficiency in patients with PANK2 mutations.
Pantethine treatment is effective in recovering the disease phenotype induced by ketogenic diet in a pantothenate kinase-associated neurodegeneration mouse model.
Partial deficit of pantothenate kinase 2 catalytic activity in a case of tremor-predominant neurodegeneration with brain iron accumulation.
Subthalamic Nuclei Stimulation in Patients With Pantothenate Kinase-Associated Neurodegeneration (PKAN).
Dyskinesias
Subthalamic Nuclei Stimulation in Patients With Pantothenate Kinase-Associated Neurodegeneration (PKAN).
[CHOLINE PANTOTHENATE IN THE THERAPY OF ATONIAS AND DYSKINESIAS OF THE BILIARY TRACT.]
Dyslexia
CNS Vasculitis in Anti-Synthetase Syndrome.
Dyslipidemias
AMPK in the small intestine in normal and pathophysiological conditions.
Dystonia
4'-Phosphopantetheine corrects CoA, iron, and dopamine metabolic defects in mammalian models of PKAN.
A patient with pantothenate kinase-associated neurodegeneration and supranuclear gaze palsy.
Botulinum Toxin-A Injection in the Treatment of Spasticity in a Infantile-Onset Neurodegeneration With Brain Iron Accumulation: A Case Report.
Cannabis Use in Children With Pantothenate Kinase-Associated Neurodegeneration.
Cerebral blood flow in dystonia due to pantothenate kinase-associated neurodegeneration.
Changes of cerebral white matter in patients suffering from Pantothenate Kinase-Associated Neurodegeneration (PKAN): A diffusion tensor imaging (DTI) study.
Characteristic "Forcible" Geste Antagoniste in Oromandibular Dystonia Resulting From Pantothenate Kinase-Associated Neurodegeneration.
Characterization of the human PANK2 promoter.
Deep brain stimulation as treatment for dystonic storm in pantothenate kinase-associated neurodegeneration syndrome: case report of a patient with homozygous C.628 2 T?>?G mutation of the PANK2 gene.
Deep brain stimulation for dystonia: a meta-analysis.
Deep brain stimulation for pantothenate kinase-associated neurodegeneration.
Deep brain stimulation for pantothenate kinase-associated neurodegeneration: A meta-analysis.
Deep brain stimulation improves quality of life in pantothenate kinase-associated neurodegeneration.
Dental appliance therapy in pantothenate kinase-associated neurodegeneration: Case report.
Electrophysiological assessment of the effect of intrathecal baclofen in dystonic children.
Grey matter alterations in patients with Pantothenate Kinase-Associated Neurodegeneration (PKAN).
Identification of a highly polymorphic microsatellite VNTR within the argininosuccinate synthetase locus: exclusion of the dystonia gene on 9q32-34 as the cause of dopa-responsive dystonia in a large kindred.
Long-term benefit to pallidal deep brain stimulation in a case of dystonia secondary to pantothenate kinase-associated neurodegeneration.
Low-frequency rTMS of the premotor cortex reduces complex movement patterns in a patient with pantothenate kinase-associated neurodegenerative disease (PKAN).
Magnetic resonance imaging in pantothenate kinase-2-associated neurodegeneration.
Metabolic consequences of mitochondrial coenzyme A deficiency in patients with PANK2 mutations.
Movement disorders in mitochondrial diseases.
Neuromodulation in dystonia: current aspects of deep brain stimulation.
Neuronal Ablation of CoA Synthase Causes Motor Deficits, Iron Dyshomeostasis, and Mitochondrial Dysfunctions in a CoPAN Mouse Model.
Pallidal stimulation for dystonia in pantothenate kinase-associated neurodegeneration.
Pallidal stimulation for pantothenate kinase-associated neurodegeneration dystonia.
Pallidal stimulation improves pantothenate kinase-associated neurodegeneration.
Pantethine treatment is effective in recovering the disease phenotype induced by ketogenic diet in a pantothenate kinase-associated neurodegeneration mouse model.
Partial deficit of pantothenate kinase 2 catalytic activity in a case of tremor-predominant neurodegeneration with brain iron accumulation.
Safety and efficacy of deferiprone for pantothenate kinase-associated neurodegeneration: a randomised, double-blind, controlled trial and an open-label extension study.
Sensory Tricks in Pantothenate Kinase-Associated Neurodegeneration: Video-Analysis of 43 Patients.
Subthalamic Nuclei Stimulation in Patients With Pantothenate Kinase-Associated Neurodegeneration (PKAN).
The eye-of-the-tiger sign is not a reliable disease marker for Hallervorden-Spatz syndrome.
Tongue Protrusion Dystonia in Pantothenate Kinase-Associated Neurodegeneration.
Dystonic Disorders
A pilot trial of deferiprone for neurodegeneration with brain iron accumulation.
Clinical and neuropsychological correlates in two brothers with pantothenate kinase-associated neurodegeneration.
Neuromodulation for neurodegenerative conditions.
Neuromodulation in dystonia: current aspects of deep brain stimulation.
Surgery for other movement disorders: dystonia, tics.
Echinococcosis
Metabolic profiling of liver and faeces in mice infected with echinococcosis.
Embolism, Air
Effect of thromboxane synthetase inhibitors (OKY-046, OKY-1580) on experimentally induced air embolism in anesthetized dogs.
Encephalitis, Viral
A comparison of interferon levels with leukocyte (2'-5') oligoadenylate synthetase activity as markers of viral encephalopathies.
Encephalomyelitis, Autoimmune, Experimental
Role of poly(ADP-ribose) synthetase activation in the development of experimental allergic encephalomyelitis.
Endometrial Neoplasms
Cholesterol Synthetase DHCR24 Induced by Insulin Aggravates Cancer Invasion and Progesterone Resistance in Endometrial Carcinoma.
Hormone dependency of carcinoma of the human endometrium. Effect of progesterone on glycogen metabolism in the carcinoma tissue.
Endometriosis
Endometriosis impairs glycogen synthesis in human endometrium.
Endotoxemia
Effects of nicotinamide, an inhibitor of PARS activity, on gut and liver O2 exchange and energy metabolism during hyperdynamic porcine endotoxemia.
Platelet-endothelial cell interaction in pulmonary micro-circulation: the role of PARS.
Poly(Adp-ribose) synthetase inhibition prevents lipopolysaccharide-induced peroxynitrite mediated damage in diaphragm.
Role of poly(ADP-ribose) synthetase in pulmonary leukocyte recruitment.
The role of poly(ADP-ribose) synthetase inhibition in preventing endotoxemia-induced intestinal epithelial apoptosis.
Eosinophilia
Fusion of TEL/ETV6 to a novel ACS2 in myelodysplastic syndrome and acute myelogenous leukemia with t(5;12)(q31;p13).
Epilepsy
Case Report.
FARS2 mutation and epilepsy: Possible link with early-onset epileptic encephalopathy.
Increased activity of oligo-2',5'-adenylate synthetase in Down's syndrome and epilepsy.
Lethal NARS2-Related Disorder Associated With Rapidly Progressive Intractable Epilepsy and Global Brain Atrophy.
Lipoic acid synthetase deficiency causes neonatal-onset epilepsy, defective mitochondrial energy metabolism, and glycine elevation.
Mutations in QARS, Encoding Glutaminyl-tRNA Synthetase, Cause Progressive Microcephaly, Cerebral-Cerebellar Atrophy, and Intractable Seizures.
The anticonvulsant actions of carisbamate associate with alterations in astrocyte glutamine metabolism in the lithium-pilocarpine epilepsy model.
Epstein-Barr Virus Infections
Increased (2'-5')-oligo-A synthetase activity in patients with prolonged illness associated with serological evidence of persistent Epstein-Barr virus infection.
Esophageal Squamous Cell Carcinoma
Using Q-RT-PCR to measure cyclin D1, TS, TP, DPD, and Her-2/neu as predictors for response, survival, and recurrence in patients with esophageal squamous cell carcinoma following radiochemotherapy.
Essential Hypertension
Two medium-chain acyl-coenzyme A synthetase genes, SAH and MACS1, are associated with plasma high-density lipoprotein cholesterol levels, but they are not associated with essential hypertension.
Essential Tremor
Pantothenate kinase-associated neurodegeneration initially presenting as postural tremor alone in a Japanese family with homozygous N245S substitutions in the pantothenate kinase gene.
Exanthema
Antisynthetase syndrome presenting as rheumatoid-like polyarthritis.
Exophthalmos
Effect of prostaglandin synthetase inhibitors on non-analgesic actions of morphine.
Facial Paralysis
[2'-5' olygoadenylate synthetase activity in peripheral facial paralysis]
Fasciitis
Angiogenesis and VEGF-expressing cells are identified predominantly in the fascia rather than in the muscle during the early phase of dermatomyositis.
Fatigue Syndrome, Chronic
Changes in the 2-5A synthetase/RNase L antiviral pathway in a controlled clinical trial with poly(I)-poly(C12U) in chronic fatigue syndrome.
Diagnostic evaluation of 2', 5'-oligoadenylate synthetase activities and antibodies against Epstein-Barr virus and Coxiella burnetii in patients with chronic fatigue syndrome in Japan.
Upregulation of the 2-5A synthetase/RNase L antiviral pathway associated with chronic fatigue syndrome.
Fatty Liver
Differential mechanisms regarding triclosan vs. bisphenol A and fluorene-9-bisphenol induced zebrafish lipid-metabolism disorders by RNA-Seq.
Effects of dietary fructose or glucose on triglyceride production and lipogenic enzyme activities in the liver of Wistar fatty rats, an animal model of NIDDM.
Fatty liver in hypervitaminosis A: synthesis and release of hepatic triglycerides.
Kipid metabolism in the rats with fatty liver caused by low protein diet and effects of the oral administration of L-methionine, L-cysteine, pantethine and calcium pantothenate upon it.
The radiographic signs of fatty liver.
Fatty Liver, Alcoholic
Hepatic lipogenesis and mobilization of peripheral fats in the formation of alcoholic fatty liver.
Fibrosarcoma
Abnormal glutathione and sulfate levels after interleukin 6 treatment and in tumor-induced cachexia.
Flavivirus Infections
Analysis of the Relationship Between Enzymatic and Antiviral Activities of the Chicken Oligoadenylate Synthetase-Like.
The Flvr-encoded murine oligoadenylate synthetase 1b (Oas1b) suppresses 2-5A synthesis in intact cells.
Foodborne Diseases
Toxin gene profiling of enterotoxic and emetic Bacillus cereus.
Friedreich Ataxia
Copper, Iron, and Manganese Toxicity in Neuropsychiatric Conditions.
New Perspectives in Iron Chelation Therapy for the Treatment of Neurodegenerative Diseases.
Potential Treatment of Retinal Diseases with Iron Chelators.
Retinal iron homeostasis in health and disease.
Synthesis of 5-[(1H-indol-3-yl)methyl]-1,3,4-oxadiazole-2(3H)-thiones and their protective activity against oxidative stress.
The History of Deferiprone (L1) and the Paradigm of the Complete Treatment of Iron Overload in Thalassaemia.
Gastroenteritis
Efficacy and safety of i.v. sodium benzoate in urea cycle disorders: a multicentre retrospective study.
Induction of the 2-5A system by interferon and transmissible gastroenteritis virus.
Genetic Diseases, Inborn
A patient with pantothenate kinase-associated neurodegeneration and supranuclear gaze palsy.
Basal ganglia calcification and novel compound heterozygous mutations in the PANK2 gene in a Chinese boy with classic Pantothenate kinase-associated neurodegeneration: A case report.
Biallelic IARS Mutations Cause Growth Retardation with Prenatal Onset, Intellectual Disability, Muscular Hypotonia, and Infantile Hepatopathy.
Divergent Cytochrome c Maturation System in Kinetoplastid Protists.
Glycyl tRNA synthetase mutations in Charcot-Marie-Tooth disease type 2D and distal spinal muscular atrophy type V.
Identification and targeted management of a neurodegenerative disorder caused by biallelic mutations in SLC5A6.
Magnetic resonance imaging pattern recognition in childhood bilateral basal ganglia disorders.
Potential Treatment of Retinal Diseases with Iron Chelators.
Safety and efficacy of deferiprone for pantothenate kinase-associated neurodegeneration: a randomised, double-blind, controlled trial and an open-label extension study.
Subthalamic Nuclei Stimulation in Patients With Pantothenate Kinase-Associated Neurodegeneration (PKAN).
Glaucoma, Open-Angle
Inducible and endothelial nitric synthetase expression and nitrotyrosine accumulation in iris vasculature of patients with primary open-angle glaucoma: a pilot study.
Glioblastoma
Cancer Association Study of Aminoacyl-tRNA Synthetase Signaling Network in Glioblastoma.
Identification of prognostic values defined by copy number variation, mRNA and protein expression of LANCL2 and EGFR in glioblastoma patients.
Neuropareidolia: diagnostic clues apropos of visual illusions.
Nuclear factor kappa B dependent induction of gamma glutamylcysteine synthetase by ionizing radiation in T98G human glioblastoma cells.
Glioma
Antitumour effect of interferon combined with hyperthermia against experimental brain tumour.
Buthionine sulfoximine induction of gamma-L-glutamyl-L-cysteine synthetase gene expression, kinetics of glutathione depletion and resynthesis, and modulation of carmustine-induced DNA-DNA cross-linking and cytotoxicity in human glioma cells.
Therapeutic strategy for targeting aggressive malignant gliomas by disrupting their energy balance.
Glomerulonephritis
Clinical effects of selective thromboxane A2 synthetase inhibitor in patients with nephrotic syndrome.
Effects of a selective thromboxane A2 synthetase inhibitor on immune complex glomerulonephritis.
[Association of the complex of polymorphic markers of ACE genes, aldosteron synthetase and endothelial synthetase of nitric oxide with progression of chronic glomerulonephritis]
[The role of polymorphic markers of vasoactive hormones genes in clinical characteristics of chronic glomerulonephritis]
Glucose Intolerance
Polymorphism of glycogen synthetase gene in polycystic ovary syndrome.
glucose-6-phosphatase deficiency
Disorders associated with purine and pyrimidine metabolism.
glutamate synthase (nadph) deficiency
Roles of SpoT and FNR in NH4+ assimilation and osmoregulation in GOGAT (glutamate synthase)-deficient mutants of Escherichia coli.
glutathione synthase deficiency
Patients with genetic defects in the gamma-glutamyl cycle.
Glycogen Storage Disease
Activities of glycogen synthetase and UDPG-pyrophosphorylase in muscle of a patient with a new type of muscle glycogenosis caused by phosphofructokinase deficiency.
[Glycogenosis with probable glycogen synthetase deficiency in a 4-year-old boy]
[Three congenital metabolic diseases in the Faeroe Islands. Incidence, clinical and molecular genetic characteristics of Faeroese children with glycogen storage disease type IIIA, carnitine transporter deficiency and holocarboxylase synthetase deficiency]
Glycogen Storage Disease Type I
Disorders associated with purine and pyrimidine metabolism.
Gout
A gouty family with increased phosphoribosylpyrophosphate synthetase activity: case reports, familial studies, and kinetic studies of the abnormal enzyme.
Accelerated transcription of PRPS1 in X-linked overactivity of normal human phosphoribosylpyrophosphate synthetase.
Altered isoelectric property of a superactive 5-phosphoribosyl-1-pyrophosphate (PRPP) synthetase in a patient with clinical gout.
Diagnostic evaluation of phosphoribosylpyrophosphate synthetase activities in hemolysates.
Effect of treatment on erythrocyte phosphoribosyl pyrophosphate synthetase and glutathione reductase activity in patients with primary gout.
Increased PP-ribose-P synthetase activity: a genetic abnormality leading to excessive purine production and gout.
Inherited superactivity of phosphoribosylpyrophosphate synthetase: association of uric acid overproduction and sensorineural deafness.
Overproduction disease in man due to enzyme feedback resistance mutation. Purine overproduction in gout due to excessive activity of mutant feedback-resistant phosphoribosylpyrophosphate synthetase.
Patterns of phosphoribosylpyrophosphate and ribose-5-phosphate concentration and generation in fibroblasts from patients with gout and purine overproduction.
Superactivity of phosphoribosylpyrophosphate synthetase, due to feedback resistance, causing purine overproduction and gout.
The mode of genetic transmission of gouty family with increased phosphoribosylpyrophosphate synthetase activity.
[Phosphoribosylpyrophosphate synthetase anomalies in 2 cases of gout beginning at an early age]
Granuloma
Pharmacologic properties of some derivatives of N-(2-carboxyphenyl)-4-phenoxyacetamide.
Graves Disease
Inhibitory effects of nicotinamide on intercellular adhesion molecule-1 expression on cultured human thyroid cells.
Nicotinamide and 3-aminobenzamide inhibit recombinant human interferon-gamma-induced HLA-DR antigen expression, but not HLA-A, B, C antigen expression, on cultured human thyroid cells.
Graves Ophthalmopathy
Nicotinamide decreases cytokine-induced activation of orbital fibroblasts from patients with thyroid-associated ophthalmopathy.
gtp cyclohydrolase i deficiency
Differential diagnosis of tetrahydrobiopterin deficiency.
Hearing Loss, Noise-Induced
Involvement of poly(ADP-ribose) synthetase in acoustic trauma of the cochlea.
Hearing Loss, Sensorineural
Novel, Compound Heterozygous, Single Nucleotide Variants in MARS2 Associated with Developmental Delay, Poor Growth, and Sensorineural Hearing Loss.
Heart Arrest
Poly-ADP-ribose polymerase inhibition protects against myocardial and endothelial reperfusion injury after hypothermic cardiac arrest.
Heart Defects, Congenital
MTHFD1 formyltetrahydrofolate synthetase deficiency, a model for the MTHFD1 R653Q variant, leads to congenital heart defects in mice.
Heart Failure
Fish oil selectively improves heart function in a mouse model of lipid-induced cardiomyopathy.
Hemochromatosis
Parkinson's Disease and Metal Storage Disorders: A Systematic Review.
Hepatic Encephalopathy
Copper, Iron, and Manganese Toxicity in Neuropsychiatric Conditions.
Hepatitis
2',5' Oligoadenylate synthetase activity in peripheral blood mononuclear cells and serum during interferon treatment of chronic non-A, non-B hepatitis.
Activities of 2'-5'oligoadenylate synthetase in peripheral blood mononuclear cells of patients with viral hepatitis, and chronic type B hepatitis during interferon therapy.
Cell-type-specific activation of the oligoadenylate synthetase-RNase L pathway by a murine coronavirus.
Detection of 2',5' oligoadenylate synthetase activity in acute viral hepatitis with special reference to histologic features in the acute stage.
Indomethacin enhances serum 2'5'-oligoadenylate synthetase in patients with hepatitis B and C virus chronic active hepatitis.
Serum 2'-5'oligoadenylate synthetase as a monitoring marker of anti-viral effect during interferon therapy for chronic type B hepatitis.
[Activity of 2, 5-oligoadenylate synthetase in non-A, non-B hepatitis]
[Non-specific immune response in acute viral hepatitis: studies from serum 2,5-oligoadenylate synthetase activity and serum and histochemical changes in beta 2 microglobulin]
[Urinary excretion of microbiologically detectable forms of pantothenic acid in viral hepatitis]
Hepatitis A
Detection of 2',5' oligoadenylate synthetase activity in acute viral hepatitis with special reference to histologic features in the acute stage.
[The use of water-soluble vitamins in viral hepatitis A]
Hepatitis B
2',5'-Oligoadenylate synthetase activity in the liver and peripheral blood mononuclear cells of chronic hepatitis patients.
Carbohydrate-dependent biological activities of glycosylated human interferon-beta on human hepatoblastoma cells in vitro.
Evidence for a deficiency of interferon production in patients with chronic hepatitis B virus infection acquired in adult life.
Indomethacin enhances serum 2'5'-oligoadenylate synthetase in patients with hepatitis B and C virus chronic active hepatitis.
The sequential change of serum 2',5' oligoadenylate synthetase in different infectious patterns of duck hepatitis B virus in ducks in experimental transmission.
[Changes in serum levels of beta 2-microglobulin, neopterin and 2',5'-oligoadenylate synthase activity during clearance of hepatitis B virus with or without acute phase in transaminases]
Hepatitis B, Chronic
2',5'-Oligoadenylate synthetase activity in peripheral blood lymphocytes as a clinical marker in interferon therapy for chronic hepatitis B.
Activities of the interferon system in patients with HBsAg-positive chronic hepatitis B during short-term steroid withdrawal therapy.
Decreased interferon binding capacity of peripheral blood mononuclear cells during interferon treatment of chronic hepatitis B with special reference to (2'-5') oligoadenylate synthetase activity.
Hepatitis C
Immunity in Different Types of Hepatitis C.
Indomethacin enhances serum 2'5'-oligoadenylate synthetase in patients with hepatitis B and C virus chronic active hepatitis.
Specific activation of 2'-5'oligoadenylate synthetase gene promoter by hepatitis C virus-core protein: a potential for developing hepatitis C virus targeting gene therapy.
Hepatitis C, Chronic
2'-,5'-Oligoadenylate synthetase response ratio predicting virological response to PEG-interferon-alpha2b plus ribavirin therapy in patients with chronic hepatitis C.
Biological basis for the clinical use of interferon.
Changes of serum 2',5'-oligoadenylate synthetase activity during interferon treatment of chronic hepatitis C.
Factors influencing the response to interferon therapy in chronic hepatitis C. Studies on viral genotype and induction of 2',5'-oligoadenylate synthetase in the liver and peripheral blood cells.
Hepatitis E
Determination of hepatitis E virus seroprevalence by using recombinant fusion proteins and synthetic peptides.
Hepatitis, Chronic
Indomethacin enhances serum 2'5'-oligoadenylate synthetase in patients with hepatitis B and C virus chronic active hepatitis.
[Mechanisms of the effect of interferon (IFN) therapy in patients with type B and C chronic hepatitis]
Hepatoblastoma
Pharmacokinetics and biologic activities of human native and asialointerferon-beta s.
Hepatolenticular Degeneration
Botulinum toxin in the treatment of sialorrhea.
Neuropareidolia: diagnostic clues apropos of visual illusions.
Neuropathology and pathogenesis of extrapyramidal movement disorders: a critical update-I. Hypokinetic-rigid movement disorders.
Parkinson's Disease and Metal Storage Disorders: A Systematic Review.
Hepatomegaly
Liver-targeted disruption of Apc in mice activates beta-catenin signaling and leads to hepatocellular carcinomas.
The hypolipidemic peroxisome-proliferating drug, bis(carboxymethylthio)-1.10 decane, a dicarboxylic metabolite of tiadenol, is activated to an acylcoenzyme A thioester.
Heredodegenerative Disorders, Nervous System
Atypical pantothenate kinase-associated neurodegeneration with variable phenotypes in an Egyptian family.
Herpes Simplex
p204-initiated innate antiviral response in mouse Leydig cells.
Herpes Zoster
Adrenocortical-specific transgene expression directed by steroid hydroxylase gene promoters.
Exploring polymorphisms and effects of candidate genes on milk fat quality in dairy sheep.
Hyperreninemic hypoaldosteronism after chronic stress in the rat.
Regulation of aldosterone in the 7-day-old rat.
Role of angiotensin: insight from gene targeting studies.
Hirschsprung Disease
[Nitric oxide and Hirschsprung's disease: a causal relation biochemically, immunohistochemically and functionally demonstrated]
HIV Infections
2',5'-oligoadenylate synthetase, neopterin and beta 2-microglobulin in asymptomatic HIV-infected individuals.
Modulation of nuclear matrix-associated 2',5'-oligoadenylate metabolism and ribonuclease L activity in H9 cells by human immunodeficiency virus.
Holocarboxylase Synthetase Deficiency
Deficiency of biotinyl-AMP synthetase activity in fibroblasts of patients with holocarboxylase synthetase deficiency.
[Three congenital metabolic diseases in the Faeroe Islands. Incidence, clinical and molecular genetic characteristics of Faeroese children with glycogen storage disease type IIIA, carnitine transporter deficiency and holocarboxylase synthetase deficiency]
Homocystinuria
[A case report of pyridoxine-responsive homocystinuria]
Huntington Disease
Changes in nine enzyme markers for neurons, glia, and endothelial cells in agonal state and Huntington's disease caudate nucleus.
Chasing shadows: What determines DTI metrics in gray matter regions? An in vitro and in vivo study.
Copper, Iron, and Manganese Toxicity in Neuropsychiatric Conditions.
Neuromodulation for neurodegenerative conditions.
New Perspectives in Iron Chelation Therapy for the Treatment of Neurodegenerative Diseases.
Vitamin B5 (d-pantothenic acid) localizes in myelinated structures of the rat brain: Potential role for cerebral vitamin B5 stores in local myelin homeostasis.
Hydatidiform Mole
Glycogen metabolism in vesicles of hydatidiform mole in vitro.
Hyperaldosteronism
[Subclinical endothelial inflammation markers in a family with type I familial hyperaldosteronism caused by a de novo mutation]
Hyperalgesia
Primary afferent nociceptor mechanisms mediating NGF-induced mechanical hyperalgesia.
Roles of thromboxane A2 and leukotriene B4 in radicular pain induced by herniated nucleus pulposus.
Hyperargininemia
Efficacy and safety of i.v. sodium benzoate in urea cycle disorders: a multicentre retrospective study.
Improving long term outcomes in urea cycle disorders-report from the Urea Cycle Disorders Consortium.
Hypercholesterolemia
Vascular endothelium dysfunction: a conservative target in metabolic disorders.
[A case report of unusual retinal findings in a patient with Zieve syndrome]
Hyperglycemia
A woman with anti-histidyl-aminoacyl-tRNA synthetase (Jo-1 antibodies), myositis, hyperglycemia, interstitial lung disease, and morbilliform rashes.
Effects of dietary fructose or glucose on triglyceride production and lipogenic enzyme activities in the liver of Wistar fatty rats, an animal model of NIDDM.
Glucose regulation by isolated near term fetal monkey liver.
Hyperglycemia and glycogen storage in the rabbit fetal liver. Role of age and hormonal status.
Hyperhomocysteinemia
Vascular endothelium dysfunction: a conservative target in metabolic disorders.
Hyperinsulinism
Effects of dietary fructose or glucose on triglyceride production and lipogenic enzyme activities in the liver of Wistar fatty rats, an animal model of NIDDM.
Hyperlipidemias
Effects of clofibric acid on the biliary excretion of benoxaprofen glucuronide and taurine conjugate in rats.
Enhanced expression of hepatic acyl-coenzyme A synthetase and microsomal triglyceride transfer protein messenger RNAs in the obese and hypertriglyceridemic rat with visceral fat accumulation.
Hypersensitivity
A double-blind, placebo-controlled trial of the thromboxane synthetase blocker OKY-046 on bronchial hypersensitivity in bronchial asthma patients.
Effect of thromboxane A2 synthetase inhibitor on immediate-type hypersensitivity reactions.
Mechanisms of arsenate tolerance in Cytisus striatus.
OsNAR2.1 interaction with OsNIT1 and OsNIT2 functions in root-growth responses to nitrate and ammonium.
The role of thromboxane A2 (TxA2) in allergic cutaneous reactions and the effect of (E)-3-[p-(1H-imidazol-1-ylmethyl) phenyl]-2-propenoic acid hydrochloride (OKY-046), a TxA2 synthetase inhibitor.
TLR4 upregulates CBS expression through NF-?B activation in a rat model of irritable bowel syndrome with chronic visceral hypersensitivity.
[Anti-allergic effects of (E)-3-[p-(1H-imidazol-1-lylmethyl) phenyl]-2-propenoic acid (OKY-046), a specific thromboxane (TX) A2 synthetase inhibitor: effects on type I allergic reactions]
[Anti-allergic effects of (E)-3-[p-(1H-imidazol-1-ylmethyl)phenyl]-2-propenoic acid (OKY-046), a specific thromboxane (TX) A2 synthetase inhibitor: effect of OKY-046 on II-IV type allergic reactions]
[Effects of a specific thromboxane A2 synthetase inhibitor on lymphocyte and neutrophil functions in adult intractable asthmatics]
[Pathogenetic investigations on a case of mauriac syndrome (author's transl)]
Hypertension
A neurovascular transmission model for acupuncture-induced nitric oxide.
Changes in renal and systemic hemodynamics after NO-synthase inhibition in males with family history of hypertension.
Delay of the initiation of hypertension in spontaneously hypertensive rats by CV-4151, a specific thromboxane A2 synthetase inhibitor.
Role of the prostaglandin-thromboxane system in the development and maintenance of spontaneous hypertension in the rat.
Serum metabolites of hypertension among Chinese adolescents aged 12-17 years.
Thromboxane A2 synthetase inhibition suppresses cough induced by angiotensin converting enzyme inhibitors.
Vascular endothelium dysfunction: a conservative target in metabolic disorders.
[Effect of calcium pantothenate on vitamin B6 and C correlation in patients with hypertension and ischemic heart disease]
Hypertension, Pregnancy-Induced
Comparative study of prostaglandin I2 (PG I2) and thromboxane A2 (TXA2) synthetase inhibitor (OKY-1581) on hemodynamics in pregnant dogs.
Hypertension, Pulmonary
Prevention of endotoxin-induced pulmonary hypertension in primates by the use of a selective thromboxane synthetase inhibitor, OKY 1581.
Hyperthyroidism
Amelioration of some metabolic effects produced by hyperthyroidism in late pregnant rats and their fetuses. Effects on lipids and proteins.
Effect of hyperthyroidism on lipogenesis in brown adipose tissue of young rats.
Effect of thyroid hormones on microsomal fatty acid chain elongation synthesis in rat liver.
Effects of experimental hypo- and hyperthyroidism on hepatic long-chain fatty acyl-CoA synthetase and hydrolase.
Glycogen and glycogen enzymes in the liver and striated muscle of rats under altered thyroid states.
Interaction between insulin and thyroid hormones on the control of carbohydrate and lipid metabolism in rat adipose tissue.
Hypertriglyceridemia
Effects of dietary fructose or glucose on triglyceride production and lipogenic enzyme activities in the liver of Wistar fatty rats, an animal model of NIDDM.
Pathogenesis of obesity by food restriction in OLETF rats-increased intestinal monoacylglycerol acyltransferase activities may be a crucial factor.
Hypobetalipoproteinemias
Current state of knowledge in Chorea-Acanthocytosis as core Neuroacanthocytosis syndrome.
Neuroacanthocytosis syndromes.
Hypoglycemia
Effect of starvation and insulin-induced hypoglycemia on oxidative stress scavenger system and electron transport chain complexes from rat brain, liver, and kidney.
Low intakes of carotene, vitamin?B2 , pantothenate and calcium predict cognitive decline among elderly patients with diabetes mellitus: The Japanese Elderly Diabetes Intervention Trial.
SYMPTOMATIC HYPOGLYCEMIA, VISCERAL FATTY METAMORPHOSIS, AND AGLYCOGENOSIS IN AN INFANT LACKING GLYCOGEN SYNTHETASE AND PHOSPHORYLAS.
[Hepatic glycogen synthetase deficiency or glycogen storage disease-zero. Mild phenotype with partial enzymatic defect]
Hypotension
Comparison between vascular plasminogen activator activity and changes in blood flow in the renal cortex in pigs.
Effects of inhibitors of poly(ADP-ribose) synthetase activity on hypotension and multiple organ dysfunction caused by endotoxin.
Hypothyroidism
Effects of experimental hypo- and hyperthyroidism on hepatic long-chain fatty acyl-CoA synthetase and hydrolase.
Glycogen and glycogen enzymes in the liver and striated muscle of rats under altered thyroid states.
Interaction between insulin and thyroid hormones on the control of carbohydrate and lipid metabolism in rat adipose tissue.
hypoxanthine phosphoribosyltransferase deficiency
Disorders associated with purine and pyrimidine metabolism.
Kinetic aspects of purine metabolism in cultured fibroblasts. A comparative study of cells from patients overproducing purines due to HGPRT deficiency and PRPP synthetase superactivity.
Mechanisms of accelerated purine nucleotide synthesis in human fibroblasts with superactive phosphoribosylpyrophosphate synthetases.
Patterns of phosphoribosylpyrophosphate and ribose-5-phosphate concentration and generation in fibroblasts from patients with gout and purine overproduction.
Purine synthesis during amino acid starvation of lymphoblasts with HPRT deficiency or PP-ribose-P synthetase overactivity decreases less than in normal cells.
Use of intact erythrocytes in the diagnosis of inherited purine and pyrimidine disorders.
Idiopathic Interstitial Pneumonias
Clinical characteristics of patients with anti-aminoacyl-tRNA synthetase antibody positive idiopathic interstitial pneumonia.
Idiopathic Pulmonary Fibrosis
Clinical characteristics of interstitial lung diseases positive to different anti-synthetase antibodies.
Oligo-2',5'-adenylate synthetase in pulmonary sarcoidosis and idiopathic pulmonary fibrosis.
Infections
2',5' oligoadenylate synthetase activity in bovine peripheral blood mononuclear cells following bovine herpesvirus type-1-induced respiratory disease: a prognostic indicator?
2',5'-Oligoadenylate synthetase 1(OAS1) inhibits PRRSV replication in Marc-145 cells.
2',5'-Oligoadenylate synthetase and interferon in peripheral blood after rubella, measles, or mumps live virus vaccine.
2',5'-Oligoadenylate synthetase expression is induced in response to heat shock.
Activation of senescence-associated Dark-inducible (DIN) genes during infection contributes to enhanced susceptibility to plant viruses.
Activity of calcium salts in controlling Phytophthora root rot of citrus.
Adenovirus-mediated gene transfer of interferon alpha inhibits hepatitis C virus replication in hepatocytes.
Alteration of nuclear (2'-5')oligoriboadenylate synthetase and nuclease activities preceding replication of human immunodeficiency virus in H9 cells.
An immunoproteomic approach for identification of clinical biomarkers for monitoring disease: application to cystic fibrosis.
An interferon-induced cellular enzyme is incorporated into virions.
Assessing gene expression during pathogenesis: Use of qRT-PCR to follow toxin production in the entomopathogenic fungus Beauveria bassiana during infection and immune response of the insect host Triatoma infestans.
Bimodular Peptide Synthetase SidE Produces Fumarylalanine in the Human Pathogen Aspergillus fumigatus.
Binding of mammalian ribosomes to MS2 phage RNA reveals an overlapping gene encoding a lysis function.
Biochemical analysis of mutants of a macrophage cell line resistant to the growth-inhibitory activity of interferon.
Chemical biology tools to study pantetheinases of the vanin family.
Comparative evaluation of permissiveness to dengue virus serotype 2 infection in primary rodent macrophages.
Contribution of MX dynamin, oligoadenylate synthetase, and protein kinase R to anti-paramyxovirus activity of type 1 interferons in vitro.
Could 2'5'-oligoadenylate synthetase isoforms be biomarkers to differentiate between disease flare and infection in lupus patients? A pilot study.
Current progress in proteomic study of hepatitis C virus-related human hepatocellular carcinoma.
Detection of elevated levels of 2-5A synthetase in serum from children with various infectious diseases.
Development of DNA mismatch repair gene, MutS, as a diagnostic marker for detection and phylogenetic analysis of algal Megaviruses.
Discovery of novel tRNA-amino acid dual-site inhibitors against threonyl-tRNA synthetase by fragment-based target hopping.
Disposition and Metabolism of GSK2251052 in Humans: A Novel Boron-containing Antibiotic.
Effect of phage on amino acid activation.
Effect of roxithromycin on respiratory bacterial infection in mice.
Evidence for a deficiency of interferon response in mononuclear cells from hepatitis C viremic patients.
Exposure to cold impairs interferon-induced antiviral defense.
Expression of interferon inducible genes following Hantaan virus infection as a mechanism of resistance in A549 cells.
Expression of pathogenesis-related genes in Metarhizium anisopliae when infecting Spodoptera exigua
Genomics-Driven Discovery of Phytotoxic Cytochalasans Involved in the Virulence of the Wheat Pathogen Parastagonospora nodorum.
Glycogen synthetase kinase 3 inhibition drives MIC-A/B to promote cytokine production by human natural killer cells in Dengue virus type 2 infection.
Glycosphingolipid GM3 is Indispensable for Dengue Virus Genome Replication.
Hepatic carbamyl phosphate synthetase and ornithine transcarbamylase in mouse influenze A and influenze B infection.
Host responses to Plasmodium yoelii hepatic stages: a paradigm in host-parasite interaction.
Human respiratory syncytial virus infection is inhibited by IFN-induced transmembrane proteins.
Identification of bacteriophage T4D gene 29 product, a baseplate hub component, as a folylpolyglutamate synthetase.
Immune sensing of mouse polyomavirus DNA by p204 and cGAS DNA sensors.
Immunization with recombinant Lactobacillus casei strains producing K99, K88 fimbrial protein protects mice against enterotoxigenic Escherichia coli.
Immunogenicity and protective efficacy of orally or intranasally administered recombinant Lactobacillus casei expressing ETEC K99.
Immunoregulation during acute infection with Epstein-Barr virus: dynamics of interferon and 2',5'-oligoadenylate synthetase activity.
In Vitro Analysis of Metabolites Secreted during Infection of Lung Epithelial Cells by Cryptococcus neoformans.
Induction of 2',5' oligo(A) synthetase in tumor-bearing mice with encephalomyocarditis (EMC) virus or poly(I)poly(C).
Induction of immune responses in mice after oral immunization with recombinant Lactobacillus casei strains expressing enterotoxigenic Escherichia coli F41 fimbrial protein.
Infection with Moloney murine sarcoma virus inhibits myogenesis and alters the myogenic-associated (2'-5')oligoadenylate synthetase expression and activity.
Influenza A induced cellular signal transduction pathways.
Interferon regulatory factor 4 contributes to transformation of v-Rel-expressing fibroblasts.
Isolation of Beauveria bassiana from the Chagas Disease Vector Triatoma infestans in the Gran Chaco Region of Argentina: Assessment of Gene Expression during Host-Pathogen Interaction.
Leaf proteome profiling of transgenic mint infected with Alternaria alternata.
Mode of action of the anti-AIDS compound poly(I).poly(C12U) (Ampligen): activator of 2',5'-oligoadenylate synthetase and double-stranded RNA-dependent kinase.
Modeling the Role of Lanthionine Synthetase C-Like 2 (LANCL2) in the Modulation of Immune Responses to Helicobacter pylori Infection.
Modulation of nuclear matrix-associated 2',5'-oligoadenylate metabolism and ribonuclease L activity in H9 cells by human immunodeficiency virus.
Molecular cloning and bioinformatic analysis of the Streptococcus agalactiae neuA gene isolated from tilapia.
Moraxella osloensis gene expression in the slug host Deroceras reticulatum.
Oligoadenylate synthetase 3 S381R gene polymorphism is associated with severity of EV71 infection in Chinese children.
Phosphoribosylpyrophosphate synthetase superactivity and recurrent infections is caused by a p.Val142Leu mutation in PRS-I.
Physcomitrella patens auxin conjugate synthetase (GH3) double knockout mutants are more resistant to Pythium infection than wild type.
Porcine 2', 5'-oligoadenylate synthetase 2 inhibits porcine reproductive and respiratory syndrome virus replication in vitro.
Protection of HeLa-T4+ cells against human immunodeficiency virus (HIV) infection after stable transfection with HIV LTR-2',5'-oligoadenylate synthetase hybrid gene.
Protective role for interferon-beta in coxsackievirus B3 infection.
Protein-protein interactions involving T4 phage-coded deoxycytidylate deaminase and thymidylate synthase.
Purification and properties of T4 phage thymidylate synthetase produced by the cloned gene in an amplification vector.
Relationship Between the Quorum Network (Sensing/Quenching) and Clinical Features of Pneumonia and Bacteraemia Caused by A. baumannii.
Role of chicken melanoma differentiation-associated gene 5 in induction and activation of innate and adaptive immune responses to infectious bursal disease virus in cultured macrophages.
Signature-tagged and directed mutagenesis identify PABA synthetase as essential for Aspergillus fumigatus pathogenicity.
Simultaneous initiation of synthesis of bacteriophage T4 DNA and of deoxyribonucleotides.
Status of urea and related enzymes during Plasmodium yoelii infection and pyrimethamine treatment in mice.
T4 phage gene 32 protein as a candidate organizing factor for the deoxyribonucleoside triphosphate synthetase complex.
Tandem cloning of bacteriophage T4 nrdA and nrdB genes and overproduction of ribonucleoside diphosphate reductase (alpha 2 beta 2) and a mutationally altered form (alpha 2 beta 2(93)).
The C/EBPbeta isoform 34-kDa LAP is responsible for NF-IL-6-mediated gene induction in activated macrophages, but is not essential for intracellular bacteria killing.
The clinical trial of streptomycin pantothenate in the treatment of soft tissue infections.
The effect of pantothenate deficiency on Trypanosoma lewisi infection in the rat.
The Yersinia pestis siderophore, yersiniabactin, and the ZnuABC system both contribute to zinc acquisition and the development of lethal septicaemic plague in mice.
Time course of interferon levels, antiviral state, 2',5'-oligoadenylate synthetase and side effects in healthy men.
Transcriptome analysis of Enterococcus faecalis during mammalian infection shows cells undergo adaptation and exist in a stringent response state.
[Immune response against Chlamydia trachomatis inoculation in mice--changes in interferon activity, antibody titers and weight of the spleen as parameters of infection]
[The chloramphenicol-calcium pantothenate complex in stubborn infections of the urinary tract.]
[Treatment of primary tuberculous infection with viomycin pantothenate.]
[Urinary protein detection by iTRAQ® associated with renal transplant complications and its modification with therapy].
Infectious Mononucleosis
Immunoregulation during acute infection with Epstein-Barr virus: dynamics of interferon and 2',5'-oligoadenylate synthetase activity.
Infertility
Glycogen metabolism of the human endometrium.
Inflammatory Bowel Diseases
(2'-5') oligo adenylate synthetase activity in leucocytes of patients with inflammatory bowel disease.
(2'-5')Oligoadenylate synthetase activity in intestinal mononuclear and epithelial cells of inflammatory bowel disease patients.
An N,N-Bis(benzimidazolylpicolinoyl)piperazine (BT-11): A Novel Lanthionine Synthetase C-Like 2-Based Therapeutic for Inflammatory Bowel Disease.
Interferon inhibits prostaglandin E2 synthesis and stimulates (2'-5')oligoadenylate synthetase activity in peripheral blood mononuclear cells of inflammatory bowel disease patients.
Modeling new immunoregulatory therapeutics as antimicrobial alternatives for treating Clostridium difficile infection.
Mucosal glucosamine synthetase activity in inflammatory bowel disease.
Nonclinical Toxicology and Toxicokinetic Profile of an Oral Lanthionine Synthetase C-Like 2 (LANCL2) Agonist, BT-11.
The Safety, Tolerability, and Pharmacokinetics Profile of BT-11, an Oral, Gut-Restricted Lanthionine Synthetase C-Like 2 Agonist Investigational New Drug for Inflammatory Bowel Disease: A Randomized, Double-Blind, Placebo-Controlled Phase I Clinical Trial.
Influenza, Human
Exposure to cold impairs interferon-induced antiviral defense.
Hepatic carbamyl phosphate synthetase and ornithine transcarbamylase in mouse influenze A and influenze B infection.
Influenza A induced cellular signal transduction pathways.
Lanthionine Synthetase C-Like 2 Modulates Immune Responses to Influenza Virus Infection.
Molecular pathogenesis of influenza A virus infection and virus-induced regulation of cytokine gene expression.
[Clinical trials of recombinant gamma-interferon. Circulating interferon and the 2,5-oligoadenylate synthetase activity after intramuscular and inhalation administrations]
Insulin Resistance
A genome scan for positive selection in thoroughbred horses.
Abdominal obesity is associated with insulin resistance and reduced glycogen synthetase activity in skeletal muscle.
Acyl CoA synthetase 5 (ACSL5) ablation in mice increases energy expenditure and insulin sensitivity and delays fat absorption.
AMPK in the small intestine in normal and pathophysiological conditions.
Diminished activities of fatty acid synthesis enzymes in insulin-resistant adipocytes from spontaneously obese rats.
Elevated PC-1 content in cultured skin fibroblasts correlates with decreased in vivo and in vitro insulin action in nondiabetic subjects: evidence that PC-1 may be an intrinsic factor in impaired insulin receptor signaling.
Endocytosis of insulin receptors is not required for activation or deactivation of the hormone response.
Genistein reduced insulin resistance index through modulating lipid metabolism in ovariectomized rats.
Insulin resistance, a result of reduced synthesis of prostaglandylinositol cyclic phosphate, a mediator of insulin action? Regulation of cyclic PIP synthetase activity by oral antidiabetic and antihypertensive drugs.
Polymorphism of glycogen synthetase gene in polycystic ovary syndrome.
Insulinoma
Binding of abscisic acid to human LANCL2.
LANCL2 is necessary for abscisic acid binding and signaling in human granulocytes and in rat insulinoma cells.
Molecular modeling of lanthionine synthetase component C-like protein 2: a potential target for the discovery of novel type 2 diabetes prophylactics and therapeutics.
Novel gene activated in rat insulinomas.
Poly(ADP-ribose) synthetase inhibitors enhance streptozotocin-induced killing of insulinoma cells by inhibiting the repair of DNA strand breaks.
Intellectual Disability
A patient with pantothenate kinase-associated neurodegeneration and supranuclear gaze palsy.
[Hepatic glycogen synthetase deficiency or glycogen storage disease-zero. Mild phenotype with partial enzymatic defect]
Intervertebral Disc Displacement
Roles of thromboxane A2 and leukotriene B4 in radicular pain induced by herniated nucleus pulposus.
Intestinal Polyposis
Suppression of intestinal polyposis in Apcmin/+ mice by targeting the nitric oxide or poly(ADP-ribose) pathways.
Intestinal Volvulus
Characterization of a possible tRNA synthetase gene from Onchocerca volvulus.
Iron Deficiencies
Bio-inorganic regulation of pathways of carbohydrate and lipid metabolism. II. The effect of iron-deficiency on the profile of enzymes in the developing rat adrenal gland.
Pyrimidine 5'nucleotidase and several other red cell enzyme activities in beta-thalassaemia trait.
Iron Overload
Retinal iron homeostasis in health and disease.
Joint Diseases
Antisynthetase Syndrome: two case report and literature review.
Degenerative knee joint disease in mice lacking 3'-phosphoadenosine 5'-phosphosulfate synthetase 2 (Papss2) activity: a putative model of human PAPSS2 deficiency-associated arthrosis.
Distinct arthropathies of the hands in patients with anti-aminoacyl tRNA synthetase antibodies: usefulness of autoantibody profiles in classifying patients.
Keratitis
Recessive Mutation in a Nuclear-Encoded Mitochondrial tRNA Synthetase Associated With Infantile Cataract, Congenital Neurotrophic Keratitis, and Orbital Myopathy.
Kernicterus
Magnetic resonance imaging pattern recognition in childhood bilateral basal ganglia disorders.
Ketosis
Effect of ketogenic diets in gestation on some characteristics of carbohydrate metabolism in fetal pig brain and liver.
Fatty acid and ketone body metabolism in the rat: response to diet and exercise.
Kidney Neoplasms
In vivo and in vitro induction of (2'-5') oligoadenylate synthetase by human interferons in leukocytes from healthy donors and patients with renal cancer and hairy cell leukemia.
Leigh Disease
Confirmation of CAGSSS syndrome as a distinct entity in a Danish patient with a novel homozygous mutation in IARS2.
Fulminant Leigh syndrome and sudden unexpected death in a family with the T9176C mutation of the mitochondrial ATPase 6 gene.
Movement disorders in mitochondrial diseases.
Lesch-Nyhan Syndrome
Kinetic aspects of purine metabolism in cultured fibroblasts. A comparative study of cells from patients overproducing purines due to HGPRT deficiency and PRPP synthetase superactivity.
Lesch-Nyhan syndrome and its pathogenesis: normal nicotinamide-adenine dinucleotide but reduced ATP concentrations that correlate with reduced poly(ADP-ribose) synthetase activity in HPRT-deficient lymphoblasts.
Severe tongue protrusion dystonia: clinical syndromes and possible treatment.
Tongue Protrusion Dystonia in Pantothenate Kinase-Associated Neurodegeneration.
Use of intact erythrocytes in the diagnosis of inherited purine and pyrimidine disorders.
Leukemia
Action of interferon-alpha on hairy cell leukemia: expression of specific receptors and (2'-5')oligo (A) synthetase in tumor cells from sensitive and resistant patients.
Analysis of the TPA regulatory element in the genomic poly(ADP-ribose) synthetase gene in human leukemia U937 cells.
Apoptosis and interferons: role of interferon-stimulated genes as mediators of apoptosis.
Calcium ionophore treatment impairs the sterol-mediated suppression of 3-hydroxy-3-methylglutaryl-coenzyme A reductase, 3-hydroxy-3-methylglutaryl-coenzyme A synthase, and farnesyl diphosphate synthetase.
Combined effects of interferon and 2'-deoxycoformycin on 2',5'-oligoadenylate synthetase and adenosine deaminase in hairy cell and chronic lymphocytic leukemia cells.
Cytotoxic mechanisms of glutamine antagonists in mouse L1210 leukemia.
Decrease of oligo-2',5'-adenylate synthetase activity in BALB3T3 cell persistently infected with Moloney murine leukemia virus.
Effects of interferon-alpha (IFN) on the expression of interleukin 1-beta (IL-1), interleukin 6 (IL-6), granulocyte-macrophage colony-stimulating factor (GM-CSF) and tumor necrosis factor-alpha (TNF) in acute myeloid leukemia (AML) blasts.
Erythroid differentiation and poly(ADP-ribose) synthesis in Friend leukemia cells.
Fluctuation of gene expression for poly(ADP-ribose) synthetase during hemin-induced erythroid differentiation of human leukemia K562 cells and its reversion process.
High expression of ganglioside alpha-2,8-sialyltransferase (GD3 synthase) gene in adult T-cell leukemia cells unrelated to the gene expression of human T-lymphotropic virus type I.
Immunological recovery and dose evaluation in IFN-alpha treatment of hairy cell leukemia: analysis of leukocyte differentiation antigens, NK and 2',5'-oligoadenylate synthetase activity.
In vivo and in vitro induction of (2'-5') oligoadenylate synthetase by human interferons in leukocytes from healthy donors and patients with renal cancer and hairy cell leukemia.
Increased levels of interferon-induced (2'--5') oligo-isoadenylate synthetase in mature T-lymphocytes and in differentiated Friend-erythroleukemic cells.
Infection with Moloney murine sarcoma virus inhibits myogenesis and alters the myogenic-associated (2'-5')oligoadenylate synthetase expression and activity.
Inhibition of interferon-gamma- and phorbol ester-induced HLA-DR and interleukin-1 production by the expression of a transfected poly(ADP-ribose) synthetase gene in human leukemia THP-1 cells.
Inhibition of the leukotriene synthetase of rat basophil leukemia cells by diethylcarbamazine, and synergism between diethylcarbamazine and piriprost, a 5-lipoxygenase inhibitor.
Isolation and characterization of interferon-resistant variants from S49 mouse lymphoma.
Lack of genotoxic and cytotoxic effects of the herbicide lenacil on mouse tumor cells and on some Salmonella typhimurium strains.
Leukemia inhibitory factor induces nociceptin mRNA in cultured rat cortical neurons.
Leukotriene C synthetase, a special glutathione S-transferase: properties of the enzyme and inhibitor studies with special reference to the mode of action of U-60,257, a selective inhibitor of leukotriene synthesis.
Maturation of human promyelocytic leukemia cells induced by nicotinamide: evidence of a regulatory role for ADP-ribosylation of chromosomal proteins.
Protein binding to the interferon response enhancer correlates with interferon induction of 2'-5'-oligoadenylate synthetase in normal and interferon-resistant Friend cells.
Purification, characterization, and structural properties of a single protein from rat basophilic leukemia (RBL-1) cells possessing 5-lipoxygenase and leukotriene A4 synthetase activities.
Response of L-1210 tumor in mice toward treatment with interferon or poly(I) X poly(C).
Retinoic acid enhances the expression of interferon-induced proteins: evidence for multiple mechanisms of action.
Role of thymidine kinase and thymidylate synthetase in the cytostatic, antimetabolic, and antitumor effects of the carbocyclic analogue of 5-nitro-2'-deoxyuridine. A comparison with 5-nitro-2'-deoxyuridine.
Subcellular distribution of 2',5'-oligoadenylate synthetase in differentiating Friend leukemia cells.
Variation of (2'-5') oligo A synthetase level in lymphocytes and granulocytes of patients with viral infections and leukemia.
Leukemia L1210
5-Substituted 2'-deoxyuridines: correlation between inhibition of tumor cell growth and inhibition of thymidine kinase and thymidylate synthetase.
Leukemia, Eosinophilic, Acute
Fusion of TEL/ETV6 to a novel ACS2 in myelodysplastic syndrome and acute myelogenous leukemia with t(5;12)(q31;p13).
Leukemia, Erythroblastic, Acute
2',5'-Oligoadenylate synthetase-uninducible alpha/beta-interferon-resistant Friend cells develop an antiviral state when permeabilized with lysolecithin and treated with 2',5'-oligoadenylate oligomers.
Comparison of the acyl chain specificities of human myristoyl-CoA synthetase and human myristoyl-CoA:protein N-myristoyltransferase.
Interferon-independent activation of (2'-5') oligoadenylate synthetase in Friend erythroleukemia cell variants exposed to HMBA.
Isolation and electron microscopic characterization of the high molecular mass aminoacyl-tRNA synthetase complex from murine erythroleukemia cells.
Leukemia, Hairy Cell
Action of interferon-alpha on hairy cell leukemia: expression of specific receptors and (2'-5')oligo (A) synthetase in tumor cells from sensitive and resistant patients.
Combined effects of interferon and 2'-deoxycoformycin on 2',5'-oligoadenylate synthetase and adenosine deaminase in hairy cell and chronic lymphocytic leukemia cells.
Effects of interferon-alpha (IFN) on the expression of interleukin 1-beta (IL-1), interleukin 6 (IL-6), granulocyte-macrophage colony-stimulating factor (GM-CSF) and tumor necrosis factor-alpha (TNF) in acute myeloid leukemia (AML) blasts.
Immunological recovery and dose evaluation in IFN-alpha treatment of hairy cell leukemia: analysis of leukocyte differentiation antigens, NK and 2',5'-oligoadenylate synthetase activity.
In vivo and in vitro induction of (2'-5') oligoadenylate synthetase by human interferons in leukocytes from healthy donors and patients with renal cancer and hairy cell leukemia.
Leukemia, Lymphocytic, Chronic, B-Cell
Combined effects of interferon and 2'-deoxycoformycin on 2',5'-oligoadenylate synthetase and adenosine deaminase in hairy cell and chronic lymphocytic leukemia cells.
Effects of interferon-alpha (IFN) on the expression of interleukin 1-beta (IL-1), interleukin 6 (IL-6), granulocyte-macrophage colony-stimulating factor (GM-CSF) and tumor necrosis factor-alpha (TNF) in acute myeloid leukemia (AML) blasts.
Increased levels of interferon-induced (2'--5') oligo-isoadenylate synthetase in mature T-lymphocytes and in differentiated Friend-erythroleukemic cells.
miR-15a and miR-16-1 down-regulation in pituitary adenomas.
Serum levels of 2',5 oligoadenylate synthetase during interferon therapy in patients with B-cell chronic lymphocytic leukemia.
Leukemia, Lymphoid
Eight genes are highly associated with BMD variation in postmenopausal Caucasian women.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Analysis of interferon-inducible genes in cells of chronic myeloid leukemia patients responsive or resistant to an interferon-alpha treatment.
Leukemia, Myeloid
Expression of a gene encoding a tRNA synthetase-like protein is enhanced in tumorigenic human myeloid leukemia cells and is cell cycle stage- and differentiation-dependent.
Leukemia, Myeloid, Acute
Fusion of TEL/ETV6 to a novel ACS2 in myelodysplastic syndrome and acute myelogenous leukemia with t(5;12)(q31;p13).
Leukoencephalopathies
AARS2 leukoencephalopathy: A new variant of mitochondrial encephalomyopathy.
An adolescence-onset male leukoencephalopathy with remarkable cerebellar atrophy and novel compound heterozygous AARS2 gene mutations: a case report.
Biallelic KARS pathogenic variants cause an early-onset progressive leukodystrophy.
Early-Onset Mild Type Leukoencephalopathy Caused by a Homozygous EARS2 Mutation.
Mutations of POLR3A Encoding a Catalytic Subunit of RNA Polymerase Pol III Cause a Recessive Hypomyelinating Leukodystrophy.
Liver Cirrhosis
Aminoacyl-tRNA synthetase interacting multi-functional protein 1 attenuates liver fibrosis by inhibiting TGF? signaling.
Serum levels of soluble interferon Alfa/Beta receptor as an inhibitory factor of interferon in the patients with chronic hepatitis C.
Liver Diseases
Ammonia metabolism in the rat liver in biliary obstruction.
Effect of OKY-046 and ONO-3708 on liver injury in mice.
Evidence for a deficiency of interferon production in patients with chronic hepatitis B virus infection acquired in adult life.
Identification of a mutation in LARS as a novel cause of infantile hepatopathy.
Inability of chronic alcoholics with liver disease to use food as a source of folates, thiamin and vitamin B6.
Lack of in vivo activation of the interferon system in HBsAg-positive chronic active hepatitis.
Mx1, OAS1 and OAS2 polymorphisms are associated with the severity of liver disease in HIV/HCV-coinfected patients: A cross-sectional study.
Serum Metabolomics Reveals ?-Glutamyl Dipeptides as Biomarkers for Discrimination among Different Forms of Liver Disease.
Liver Diseases, Alcoholic
S-Adenosyl-L-methionine and alcoholic liver disease in animal models: implications for early intervention in human beings.
Liver Failure
Deep phenotyping of MARS1 (interstitial lung and liver disease) and LARS1 (infantile liver failure syndrome 1) recessive multisystemic disease using Human Phenotype Ontology annotation: Overlap and differences. Case report and review of literature.
Severe Neonatal Manifestations of Infantile Liver Failure Syndrome Type 1 Caused by Cytosolic Leucine-tRNA Synthetase Deficiency.
Liver Neoplasms
Carbamyl phosphate synthetases in rat liver neoplasms.
Regression of hepatocellular cancer in a patient treated with arginine deiminase.
[Characteristics of gene expression of adrenal cortical steroid synthetase and its regulatory factor in mice with H22 liver cancer of different patterns].
Liver Neoplasms, Experimental
Inhibition of 5-phosphoribosyl-1-pyrophosphate synthetase by the monophosphate metabolite of 4-amino-8-(beta-D-ribofuranosylamino)pyrimido[5,4-d]pyrimidine: a novel mechanism for antitumor activity.
Substrate and hormone regulation of palmitoyl-CoA synthetase in 7800 C1 Morris hepatoma cells and cultured rat hepatocytes.
long-chain acyl-coa dehydrogenase deficiency
Altered Metabolic Flexibility in Inherited Metabolic Diseases of Mitochondrial Fatty Acid Metabolism.
Lung Diseases
Antisynthetase Syndrome: two case report and literature review.
Bi-allelic Mutations in Phe-tRNA Synthetase Associated with a Multi-system Pulmonary Disease Support Non-translational Function.
Clinicoserological features of antisynthetase syndrome (ASyS)-associated interstitial lung disease presenting to respiratory services: comparison with idiopathic pulmonary fibrosis and ASyS diagnosed in rheumatology services.
Lung Diseases, Interstitial
A case of anti-aminoacyl tRNA synthetase (ARS) antibody-positive polymyositis (PM)/dermatomyositis (DM)-associated interstitial pneumonia (IP) successfully controlled with bosentan therapy.
A case of interstitial lung disease with anti-EJ and anti-CCP antibodies preceding rheumatoid arthritis.
A new approach to the classification of idiopathic inflammatory myopathy: myositis-specific autoantibodies define useful homogeneous patient groups.
A woman with anti-histidyl-aminoacyl-tRNA synthetase (Jo-1 antibodies), myositis, hyperglycemia, interstitial lung disease, and morbilliform rashes.
Acute Onset Anti-Synthetase Syndrome With Pericardial Effusion and Non-Specific Interstitial Pneumonia.
Acute respiratory distress syndrome secondary to antisynthetase syndrome is reversible with tacrolimus.
Anti-aminoacyl-tRNA synthetase antibodies in clinical course prediction of interstitial lung disease complicated with idiopathic inflammatory myopathies.
Anti-glycyl tRNA synthetase antibody associated interstitial lung disease without symptoms of polymyositis/dermatomyositis.
Anti-Ro52 antibodies, antisynthetase antibodies, and antisynthetase syndrome.
Anti-Ro52 autoantibodies are associated with interstitial lung disease and more severe disease in patients with juvenile myositis.
Anti-tRNA synthetase syndrome interstitial lung disease: A single center experience.
Antisynthetase syndrome associated with sarcoidosis.
Antisynthetase syndrome presenting as rheumatoid-like polyarthritis.
Antisynthetase syndrome: An under-recognized cause of interstitial lung disease.
Autoantibodies to glycyl-transfer RNA synthetase in myositis. Association with dermatomyositis and immunologic heterogeneity.
Biomarkers and Autoantibodies of Interstitial Lung Disease with Idiopathic Inflammatory Myopathies.
Clinical and immunogenetic features of patients with autoantibodies to asparaginyl-transfer RNA synthetase.
Clinical and pathological findings of interstitial lung disease patients with anti-aminoacyl-tRNA synthetase autoantibodies.
Clinical characteristics of interstitial lung diseases positive to different anti-synthetase antibodies.
Clinical characteristics of patients with anti-aminoacyl-tRNA synthetase antibody positive idiopathic interstitial pneumonia.
Clinical manifestations in patients with antibody to PL-12 antigen (alanyl-tRNA synthetase).
Clinical manifestations of skin, lung and muscle diseases in dermatomyositis positive for anti-aminoacyl tRNA synthetase antibodies.
Clinical significance and new detection system of autoantibodies in myositis with interstitial lung disease.
Clinical significance of anti-histidyl-tRNA synthetase (Jo1) autoantibodies.
Clinical significance of myositis-specific autoantibodies.
Clinical significance of radiological patterns of HRCT and their association with macrophage activation in dermatomyositis.
Clinical, radiological, and pathological features of anti-asparaginyl tRNA synthetase antibody-related interstitial lung disease.
Comparison of anti-aminoacyl-tRNA synthetase antibody-related and idiopathic non-specific interstitial pneumonia.
Comparison of long-term prognosis and relapse of dermatomyositis complicated with interstitial pneumonia according to autoantibodies: anti-aminoacyl tRNA synthetase antibodies versus anti-melanoma differentiation-associated gene 5 antibody.
Comparison of Pulmonary Involvement Between Patients Expressing Anti-PL-7 and Anti-Jo-1 Antibodies.
Correlation of Antisynthetase Antibody Levels with Disease Course in a Patient with Interstitial Lung Disease and Elevated Muscle Enzymes.
Dermatomyositis: an association of gingival telangiectases and anti Jo-1 antibody in the adult.
Development of antisynthetase syndrome in a patient with rheumatoid arthritis.
Efficacy of Glucocorticoids and Calcineurin Inhibitors for Anti-aminoacyl-tRNA Synthetase Antibody-positive Polymyositis/dermatomyositis-associated Interstitial Lung Disease: A Propensity Score-matched Analysis.
Elevated serum B-cell activating factor levels in patients with dermatomyositis: Association with interstitial lung disease.
Establishment of an ELISA to detect anti-glycyl-tRNA synthetase antibody (anti-EJ), a serological marker of dermatomyositis/polymyositis and interstitial lung disease.
Glycyl-tRNA synthetase.
HLA-DRB1*0101/*0405 is associated with susceptibility to Anti-MDA5 antibody-positive dermatomyositis in the Japanese population.
Interstitial lung disease associated with anti-PM/Scl or anti-aminoacyl-tRNA synthetase autoantibodies: a similar condition?
Involvement of NK Cells and NKp30 Pathway in Antisynthetase Syndrome.
Long-term clinical course of anti-glycyl tRNA synthetase (anti-EJ) antibody-related interstitial lung disease pathologically proven by surgical lung biopsy.
Nivolumab-induced anti-aminoacyl-tRNA synthetase antibody-positive polymyositis complicated by interstitial pneumonia in a patient with lung adenocarcinoma.
Oxygen-Dependent Patient with Antisynthetase Syndrome Associated Interstitial Lung Disease Responds Promptly to Rituximab with Rapid Pulmonary Function Improvement.
Patients with anti-Jo1 antibodies display a characteristic IgG Fc-glycan profile which is further enhanced in anti-Jo1 autoantibodies.
Plasma homocysteine levels are positively associated with interstitial lung disease in dermatomyositis patients with anti-aminoacyl-tRNA synthetase antibody.
Potential of Krebs von den Lungen-6 as a predictor of relapse in interstitial pneumonia with anti-aminoacyl tRNA synthetase antibodies-positive dermatomyositis.
Predictive Factors for the Long-Term Deterioration of Pulmonary Function in Interstitial Lung Disease Associated with Anti-Aminoacyl-tRNA Synthetase Antibodies.
Predictive factors for the recurrence of anti-aminoacyl-tRNA synthetase antibody-associated interstitial lung disease.
Prognosis of Interstitial Lung Disease Associated with Anti-Aminoacyl-tRNA Synthetase Antibodies: Look in the Middle.
Prognostic significance of anti-aminoacyl-tRNA synthetase antibodies in polymyositis/dermatomyositis-associated interstitial lung disease: a retrospective case control study.
Scleroderma overlap syndromes.
Serial measurements of KL-6 for monitoring activity and recurrence of interstitial pneumonia with anti-aminoacyl-tRNA synthetase antibody: A retrospective cohort study.
Tacrolimus-induced diabetic ketoacidosis with subsequent rapid recovery of endogenous insulin secretion after cessation of tacrolimus: A case report with review of literature.
The Association of Anti-Aminoacyl-Transfer Ribonucleic Acid Synthetase Antibodies in Patients With Rheumatoid Arthritis and Interstitial Lung Disease.
The comparison of nailfold videocapillaroscopy findings between anti-melanoma differentiation-associated gene 5 antibody and anti-aminoacyl tRNA synthetase antibody in patients with dermatomyositis complicated by interstitial lung disease.
The long-term outcome of interstitial lung disease with anti-aminoacyl-tRNA synthetase antibodies.
The Onset of Eosinophilic Pneumonia Preceding Anti-synthetase Syndrome.
The pulmonary histopathologic manifestations of the anti-Jo-1 tRNA synthetase syndrome.
The relationship between type 1 IFN and vasculopathy in anti-MDA5 antibody-positive dermatomyositis patients.
Two cases with autoantibodies to small ubiquitin-like modifier activating enzyme: A potential unique subset of dermatomyositis-associated interstitial lung disease.
[Antisynthetase syndromes].
[Clinical and pathological findings of patients with interstitial lung disease associated with antisynthetase]
[Interstitial lung disease in patients with connective tissue diseases]
[Myositis-related interstitial lung disease and antisynthetase syndrome.]
[Progress of Autoantibody Examinations for Connective Tissue Diseases].
Lung Injury
Novel insights into phosgene-induced acute lung injury in rats: role of dysregulated cardiopulmonary reflexes and nitric oxide in lung edema pathogenesis.
Rationally designed pure-inorganic upconversion nanoprobes for ultra-highly selective hydrogen sulfide imaging and elimination in vivo.
Role of arachidonic acid metabolites in oleic acid induced pulmonary injury in a canine model. Effect of ketoconazole (thromboxane synthetase inhibitor).
Lung Neoplasms
2-Aminophenylpyrimidines as Novel Inhibitors of Aminoacyl-tRNA Synthetase Interacting Multifunctional Protein 2 (AIMP2)-DX2 for Lung Cancer Treatment.
A novel human tRNA-dihydrouridine synthase involved in pulmonary carcinogenesis.
Cell type-specific differences in metabolic activation of N-nitrosodiethylamine by human lung cancer cell lines.
IARS2 silencing induces non-small cell lung cancer cells proliferation inhibition, cell cycle arrest and promotes cell apoptosis.
Indomethacin-mediated enhancement of lymphocyte response to mitogens in healthy subjects and lung cancer patients.
Inhibiting DX2-p14/ARF Interaction Exerts Antitumor Effects in Lung Cancer and Delays Tumor Progression.
Investigation of myositis and scleroderma specific autoantibodies in patients with lung cancer.
Label-free molecular probe based on G-quadruplex and strand displacement for sensitive and selective detection and naked eye discrimination of exon 2 deletion of AIMP2.
Overcoming Radiation Resistance by Iron-Platinum Metal Alloy Nanoparticles in Human Copper Transport 1-Overexpressing Cancer Cells via Mitochondrial Disturbance.
Lupus Erythematosus, Discoid
Treatment of subacute and chronic discoid lupus erythematosus with intensive calcium pantothenate therapy.
Lupus Erythematosus, Systemic
A sensitive immunoenzymometric assay for 2',5'-oligoadenylate. Detection of elevated 2',5'-oligoadenylate synthetase in human peripheral mononuclear cells.
Could 2'5'-oligoadenylate synthetase isoforms be biomarkers to differentiate between disease flare and infection in lupus patients? A pilot study.
Interferon-induced 2'-5' adenylate synthetase in vivo and interferon production in vitro by lymphocytes from systemic lupus erythematosus patients with and without circulating interferon.
Oligo-2',5'-adenylate synthetase activity in peripheral blood mononuclear leukocytes in various diseases.
[The correlation of myxovirus resistance 1 and 2'5'-ollgoadenylate synthetase 1 with clinical features of systemic lupus erythematosus]
Lupus Nephritis
Abnormal prostanoid metabolism in lupus nephritis and the effects of a thromboxane A2 synthetase inhibitor, DP-1904.
Improvement of renal function with a selective thromboxane A2 synthetase inhibitor, DP-1904, in lupus nephritis.
Production of thromboxane A2 and prostaglandin i2 affected by interaction of heat aggregated IgG, endothelial cells, and platelets in lupus nephritis.
[Oxidation status and ?-glutamylcysteine synthetase expression in the kidney of MRL/lpr lupus mice].
Lymphatic Metastasis
[Relationship between the anti-metastatic effect of UFT and in vitro chemosensitivity to 5-FU in metastatic tumors from orthotopic implanted colon cancer in nude rats]
Lymphocytic Choriomeningitis
Altered tissue distribution of viral replication and T cell spreading is pivotal in the protection against fatal lymphocytic choriomeningitis in mice after neutralization of IFN-alpha/beta.
Lymphohistiocytosis, Hemophagocytic
A case of anti-aminoacyl tRNA synthetase antibody syndrome complicated by hemophagocytic syndrome.
[A case of atrial septal defect complicated by persistent left superior vena cava in whom hemophagocytic syndrome appeared after operation]
Lymphoma
Clinical significance of polyglutamylation in primary central nervous system lymphoma.
Enhanced expression of poly(ADP-ribose) synthetase gene in malignant lymphoma.
L-asparaginyl-tRNA synthetase and L-asparagine synthetase activities of L-asparaginase-sensitive and -resistant forms of the mouse Gardner lymphoma 6C3HED.
Participation of poly(ADP-ribosyl)ation in the depression of RNA synthesis caused by treatment of mouse lymphoma cells with methylnitrosourea.
The effect of tumour growth on liver pantothenate, CoA, and fatty acid synthetase activity in the mouse.
Lymphoma, B-Cell
Effects of dietary protein levels on the disease resistance, immune function and physical barrier function in the gill of grass carp (Ctenopharyngodon idella) after challenged with Flavobacterium columnare.
Optimal dietary protein level improved growth, disease resistance, intestinal immune and physical barrier function of young grass carp (Ctenopharyngodon idella).
Lymphoma, Large B-Cell, Diffuse
Enhancement of interferon-induced 2-5 oligoadenylate synthetase activity by retinoic acid in human histiocytic lymphoma U937 cells and WISH cells.
Lymphoma, Non-Hodgkin
Alterations in hepatic heme and cytochrome P-450 metabolism in Murphy-Sturm lymphosarcoma-bearing rats. Implications for drug metabolism.
Malabsorption Syndromes
[Activity of glucosamine synthetase in the small intestine mucosa in children with malabsorption syndromes]
Malaria
Activation of Anopheles stephensi Pantothenate Kinase and Coenzyme A Biosynthesis Reduces Infection with Diverse Plasmodium Species in the Mosquito Host.
Analogs of natural aminoacyl-tRNA synthetase inhibitors clear malaria in vivo.
Characterisation of the dihydrofolate reductase-thymidylate synthetase gene from human malaria parasites highly resistant to pyrimethamine.
Developing Pantetheinase-Resistant Pantothenamide Antibacterials: Structural Modification Impacts on PanK Interaction and Mode of Action.
Drug targeting of one or more aminoacyl-tRNA synthetase in the malaria parasite Plasmodium falciparum.
Exploiting the coenzyme A biosynthesis pathway for the identification of new antimalarial agents: the case for pantothenamides.
Feedback inhibition of pantothenate kinase regulates pantothenol uptake by the malaria parasite.
Genetic Characterization of Coenzyme A Biosynthesis Reveals Essential Distinctive Functions during Malaria Parasite Development in Blood and Mosquito.
Genetic Characterization of Plasmodium Putative Pantothenate Kinase Genes Reveals Their Essential Role in Malaria Parasite Transmission to the Mosquito.
H+-coupled pantothenate transport in the intracellular malaria parasite.
Identification and functional analysis of the primary pantothenate transporter, PfPAT, of the human malaria parasite Plasmodium falciparum.
Insights into the preclinical treatment of blood-stage malaria by the antibiotic borrelidin.
Novel pantothenate derivatives for anti-malarial chemotherapy.
Pantothenamides are potent, on-target inhibitors of Plasmodium falciparum growth when serum pantetheinase is inactivated.
Piperaquine and Lumefantrine resistance in Plasmodium berghei ANKA associated with increased expression of Ca2+/H+ antiporter and glutathione associated enzymes.
Plasmodium yoelii vitamin B5 pantothenate transporter candidate is essential for parasite transmission to the mosquito.
Structure-activity analysis of CJ-15,801 analogues that interact with Plasmodium falciparum pantothenate kinase and inhibit parasite proliferation.
The cytoplasmic prolyl-tRNA synthetase of the malaria parasite is a dual-stage target of febrifugine and its analogs.
The dihydrofolate reductase-thymidylate synthetase gene in the drug resistance of malaria parasites.
The growing pipeline of natural aminoacyl-tRNA synthetase inhibitors for malaria treatment.
Malaria, Avian
The human malaria parasite Plasmodium falciparum is not dependent on host coenzyme A biosynthesis.
Malnutrition
Effect of malnutrition on susceptibility of rats to Trypanosoma cruzi. III. Pantothenate deficiency.
Maple Syrup Urine Disease
Continuous venovenous haemofiltration in the acute treatment of inborn errors of metabolism.
Mastocytoma
Influence of nitric oxide on the intracellular reduced glutathione pool: different cellular capacities and strategies to encounter nitric oxide-mediated stress.
Measles
2',5'-Oligoadenylate synthetase and interferon in peripheral blood after rubella, measles, or mumps live virus vaccine.
Oligo-2',5'-adenylate synthetase activity in K562 cell lines persistently infected with measles or mumps virus.
Melanoma
Disulfiram induces apoptosis in human melanoma cells: a redox-related process.
Effects of alpha- and beta-arbutin on activity of tyrosinases from mushroom and mouse melanoma.
Evaluation of usefulness in surfactant protein D as a predictor of mortality in myositis-associated interstitial lung disease.
Evaluation on serum 2'-5'oligoadenylate synthetase (2'-5'oligoAS) and beta 2 microglobulin (B2M) in patients with nodal metastases from cutaneous malignant melanoma treated with rIFN-alpha 2A.
Growth regulation of melanoma cells by interferon and (2'-5')oligoadenylate synthetase.
In vivo induction of the interferon-stimulated protein 2'5'-oligoadenylate synthetase in tumor and peripheral blood cells during IFN-alpha treatment of metastatic melanoma.
Induction of arginosuccinate synthetase (ASS) expression affects the antiproliferative activity of arginine deiminase (ADI) in melanoma cells.
Recombinant human IFN-gamma, but not IFN-alpha or IFN-beta, enhances MHC- and non-MHC-encoded glycoproteins by a protein synthesis-dependent mechanism.
Role of PRPS2 as a prognostic and therapeutic target in osteosarcoma.
[Serum interferon level and (2'-5')-oligo(A) synthetase activity in malignant melanoma]
[Serum interferon level and (2'-5')-oligo(A) synthetase activity in pityriasis rosea, basalioma, melanoma and molluscum contagiosum]
Melanoma, Experimental
Effects of D-threo-PDMP, an inhibitor of glucosylceramide synthetase, on expression of cell surface glycolipid antigen and binding to adhesive proteins by B16 melanoma cells.
Resistance to the antiproliferative activity of IFN-alpha: further characterization and demonstration of antagonistic effects of IFN-gamma.
Melioidosis
A plant pathogen virulence factor inhibits the eukaryotic proteasome by a novel mechanism.
Meningitis
3-Aminobenzamide, a poly (ADP-ribose) synthetase inhibitor, attenuates the acute inflammatory responses and brain injury in experimental Escherichia coli meningitis in the newborn piglet.
Site-specific immobilization of enzymes on magnetic nanoparticles and their use in organic synthesis.
Meningitis, Bacterial
3-Aminobenzamide, a poly (ADP-ribose) synthetase inhibitor, attenuates the acute inflammatory responses and brain injury in experimental Escherichia coli meningitis in the newborn piglet.
Meningitis, Escherichia coli
3-Aminobenzamide, a poly (ADP-ribose) synthetase inhibitor, attenuates the acute inflammatory responses and brain injury in experimental Escherichia coli meningitis in the newborn piglet.
Meningitis, Viral
[Early diagnosis of central nervous system (CNS) viral infections in the neonatal period and early infancy]
Menorrhagia
Clinical experience with Norplant subdermal implant system as long-term contraception during adolescence.
Mesenteric Ischemia
Poly (ADP-ribose) synthetase mediates intestinal mucosal barrier dysfunction after mesenteric ischemia.
Mesothelioma
Folylpoly-Glutamate Synthetase Expression Is Associated with Tumor Response and Outcome from Pemetrexed-Based Chemotherapy in Malignant Pleural Mesothelioma.
Mesothelioma, Malignant
Folylpoly-Glutamate Synthetase Expression Is Associated with Tumor Response and Outcome from Pemetrexed-Based Chemotherapy in Malignant Pleural Mesothelioma.
Metabolic Diseases
[A new inherited metabolic disease: delta1-pyrroline 5-carboxylate synthetase deficiency]
[Three congenital metabolic diseases in the Faeroe Islands. Incidence, clinical and molecular genetic characteristics of Faeroese children with glycogen storage disease type IIIA, carnitine transporter deficiency and holocarboxylase synthetase deficiency]
Metabolic Syndrome
Intestinal Population in Host with Metabolic Syndrome during Administration of Chitosan and Its Derivatives.
LOWER URINARY TRACT SYMPTOMS AND ERECTILE DYSFUNCTION.
methylcrotonoyl-coa carboxylase deficiency
[Screening for newborn organic aciduria in Zhejiang province:prevalence, outcome and follow-up].
Microcephaly
Congenital Visual Impairment and Progressive Microcephaly Due to Lysyl-Transfer Ribonucleic Acid (RNA) Synthetase (KARS) Mutations: The Expanding Phenotype of Aminoacyl-Transfer RNA Synthetase Mutations in Human Disease.
Expansion of the QARS deficiency phenotype with report of a family with isolated supratentorial brain abnormalities.
Microphthalmos
Cloning and characterization of a putative human holocytochrome c-type synthetase gene (HCCS) isolated from the critical region for microphthalmia with linear skin defects (MLS).
Genomic structure of a human holocytochrome c-type synthetase gene in Xp22.3 and mutation analysis in patients with Rett syndrome.
Loss of holocytochrome c-type synthetase causes the male lethality of X-linked dominant microphthalmia with linear skin defects (MLS) syndrome.
Mitochondrial Diseases
A novel compound heterozygous mutation in VARS2 in a newborn with mitochondrial cardiomyopathy: a case report of a Chinese family.
A patient with juvenile-onset refractory status epilepticus caused by two novel compound heterozygous mutations in FARS2 gene.
Metabolic profiles of exercise in patients with McArdle disease or mitochondrial myopathy.
Mitochondrial Encephalopathy: First Portuguese Report of a VARS2 Causative Variant.
Mitochondrial phenylalanyl-tRNA synthetase mutations underlie fatal infantile Alpers encephalopathy.
Mixed Connective Tissue Disease
Scleroderma overlap syndromes.
Molluscum Contagiosum
[Serum interferon level and (2'-5')-oligo(A) synthetase activity in pityriasis rosea, basalioma, melanoma and molluscum contagiosum]
Motor Neuron Disease
Glycyl tRNA synthetase mutations in Charcot-Marie-Tooth disease type 2D and distal spinal muscular atrophy type V.
Mouth Neoplasms
Extracellular 2'5'-oligoadenylate synthetase 2 mediates T-cell receptor CD3-? chain down-regulation via caspase-3 activation in oral cancer.
Movement Disorders
Deep brain stimulation for pantothenate kinase-associated neurodegeneration: A meta-analysis.
Deep brain stimulation improves quality of life in pantothenate kinase-associated neurodegeneration.
Deprivation of pantothenic acid elicits a movement disorder and azoospermia in a mouse model of pantothenate kinase-associated neurodegeneration.
Mitochondrial iron and energetic dysfunction distinguish fibroblasts and induced neurons from pantothenate kinase-associated neurodegeneration patients.
Neurologic phenotypes associated with acanthocytosis.
Novel histopathologic findings in molecularly-confirmed pantothenate kinase-associated neurodegeneration.
Pallidal neuronal apolipoprotein E in pantothenate kinase-associated neurodegeneration recapitulates ischemic injury to the globus pallidus.
Sequence Variations in Mitochondrial Ferritin: Distribution in Healthy Controls and Different Types of Patients.
The FOsmetpantotenate Replacement Therapy (FORT) randomized, double-blind, Placebo-controlled pivotal trial: Study design and development methodology of a novel primary efficacy outcome in patients with pantothenate kinase-associated neurodegeneration.
Multiple Myeloma
2',5'-Oligoadenylate synthetase levels in patients with multiple myeloma receiving maintenance therapy with interferon alpha 2b do not correlate with clinical response.
Abnormal platelet glycogen metabolism in multiple myeloma patients.
Multiple Sclerosis
Interferon induction, 2'-5' oligo A synthetase and lymphocyte subpopulations in out-patients with multiple sclerosis in a longitudinal study.
Multiple System Atrophy
Botulinum toxin in the treatment of sialorrhea.
Chasing shadows: What determines DTI metrics in gray matter regions? An in vitro and in vivo study.
Mumps
2',5'-Oligoadenylate synthetase and interferon in peripheral blood after rubella, measles, or mumps live virus vaccine.
Antiviral responses of human Leydig cells to mumps virus infection or poly I:C stimulation.
Investigation of IFN type-I receptor and IFN regulatory factor expression relating to induction of 2', 5'-oligoadenylate synthetase in cells persistently infected with the mumps virus.
Oligo-2',5'-adenylate synthetase activity in K562 cell lines persistently infected with measles or mumps virus.
Suppression of interferon-induced oligo-2',5'-adenylate synthetase induction in persistent infection.
Muscle Cramp
[Pathogenesis of cramp in pregnancy and its therapy with pantothenate.]
Muscle Weakness
Drop Head Syndrome as a Rare Complication in Mixed Connective Tissue Disease.
Muscular Diseases
Recessive Mutation in a Nuclear-Encoded Mitochondrial tRNA Synthetase Associated With Infantile Cataract, Congenital Neurotrophic Keratitis, and Orbital Myopathy.
[Effect of repeated administration of glucocorticoid on the glycogen level of mouse muscle (author's transl)]
Myalgia
A Rare Combination of Dermatomyositis, Interstitial Pneumonia, and Lung Cancer in a Patient Treated with Immunosuppressive Therapy and Chemotherapy.
Identification of viral infections in pregnancy by assay of (2'-5')-oligo-isoadenylate synthetase.
Myelitis
Treatment with green tea extract attenuates secondary inflammatory response in an experimental model of spinal cord trauma.
Myelodysplastic Syndromes
Sequence Variations in Mitochondrial Ferritin: Distribution in Healthy Controls and Different Types of Patients.
Myocardial Infarction
Different angiogenesis effect of mini-TyrRS/mini-TrpRS by systemic administration of modified siRNAs in rats with acute myocardial infarction.
Effect of Mini-Tyrosyl-tRNA Synthetase/Mini-Tryptophanyl-tRNA Synthetase on Angiogenesis in Rhesus Monkeys after Acute Myocardial Infarction.
Effect of mini-tyrosyl-tRNA synthetase/mini-tryptophanyl-tRNA synthetase on ischemic angiogenesis in rats: proliferation and migration of endothelial cells.
High expression of long chain acyl-coenzyme A synthetase 1 in peripheral blood may be a molecular marker for assessing the risk of acute myocardial infarction.
Natural aminoacyl tRNA synthetase fragment enhances cardiac function after myocardial infarction.
Prevention of myocardial reperfusion injury by poly(ADP-ribose) synthetase inhibitor, 3-aminobenzamide, in cardioplegic solution: in vitro study of isolated rat heart model.
Reduced myocardial neutrophil accumulation and infarct size following thromboxane synthetase inhibitor or receptor antagonist.
Reduction in myocardial neutrophil accumulation and infarct size following administration of thromboxane inhibitor U-63,557A.
[Amino acyl tRNA synthetase complexes in rabbit liver in experimental myocardial infarction]
[Distribution of aminoacyl-t-RNA-synthetase activity in rabbit liver cells during disruption of protein biosynthesis in experimental myocardia infarct]
Myocardial Ischemia
Protection against myocardial ischemia and reperfusion injury by 3-aminobenzamide, an inhibitor of poly (ADP-ribose) synthetase.
Subcellular distribution and properties of rabbit liver aminoacyl-tRNA synthetases under myocardial ischemia.
[Effect of calcium pantothenate on vitamin B6 and C correlation in patients with hypertension and ischemic heart disease]
Myocardial Reperfusion Injury
Prevention of myocardial reperfusion injury by poly(ADP-ribose) synthetase inhibitor, 3-aminobenzamide, in cardioplegic solution: in vitro study of isolated rat heart model.
Reduction of myocardial reperfusion injury by an inhibitor of poly (ADP-ribose) synthetase in the pig.
Myoclonic Epilepsies, Progressive
Huntington's disease look-alikes.
Myoclonus
Novel Compound Heterozygous Mutations Expand the Recognized Phenotypes of FARS2-Linked Disease.
Myositis
A motif in human histidyl-tRNA synthetase which is shared among several aminoacyl-tRNA synthetases is a coiled-coil that is essential for enzymatic activity and contains the major autoantigenic epitope.
A woman with anti-histidyl-aminoacyl-tRNA synthetase (Jo-1 antibodies), myositis, hyperglycemia, interstitial lung disease, and morbilliform rashes.
Acute Onset Anti-Synthetase Syndrome With Pericardial Effusion and Non-Specific Interstitial Pneumonia.
Anti-aminoacyl tRNA synthetase immune responses: insights into the pathogenesis of the idiopathic inflammatory myopathies.
Anti-aminoacyl-tRNA synthetase antibodies in clinical course prediction of interstitial lung disease complicated with idiopathic inflammatory myopathies.
Anti-PL-7 (anti-threonyl-tRNA synthetase) antisynthetase syndrome: clinical manifestations in a series of patients from a European multicenter study (EUMYONET) and review of the literature.
Anti-Ro52 antibodies frequently co-occur with anti-Jo-1 antibodies in sera from patients with idiopathic inflammatory myopathy.
Anti-Ro52 antibodies, antisynthetase antibodies, and antisynthetase syndrome.
Anti-Ro52 autoantibodies are associated with interstitial lung disease and more severe disease in patients with juvenile myositis.
Antisynthetase syndrome associated with sarcoidosis.
Antisynthetase syndrome presenting as rheumatoid-like polyarthritis.
Antisynthetase syndrome: An under-recognized cause of interstitial lung disease.
Antisynthetase Syndrome: two case report and literature review.
Clinical and immunogenetic features of patients with autoantibodies to asparaginyl-transfer RNA synthetase.
Clinical characteristics of interstitial lung diseases positive to different anti-synthetase antibodies.
Clinical manifestations in patients with antibody to PL-12 antigen (alanyl-tRNA synthetase).
Clinical significance of anti-histidyl-tRNA synthetase (Jo1) autoantibodies.
Clinical, radiological, and pathological features of anti-asparaginyl tRNA synthetase antibody-related interstitial lung disease.
Correlation of Antisynthetase Antibody Levels with Disease Course in a Patient with Interstitial Lung Disease and Elevated Muscle Enzymes.
Dermatomyositis: an association of gingival telangiectases and anti Jo-1 antibody in the adult.
Do associated auto-antibodies influence the outcome of myasthenia gravis after thymectomy?
Early predominant inflammatory myopathy in anti-glycyl-tRNA synthetase (EJ) antibody positive antisynthetase syndrome.
Efficacy of Rituximab in Refractory Inflammatory Myopathies Associated with Anti- Synthetase Auto-Antibodies: An Open-Label, Phase II Trial.
Epidemiology of Idiopathic Inflammatory Myopathies in Africa: A Contemporary Systematic Review.
Establishment of an ELISA to detect anti-glycyl-tRNA synthetase antibody (anti-EJ), a serological marker of dermatomyositis/polymyositis and interstitial lung disease.
Genome-wide association study identifies HLA 8.1 ancestral haplotype alleles as major genetic risk factors for myositis phenotypes.
Immune recognition of lysyl-tRNA synthetase and isoleucyl-tRNA synthetase by anti-OJ antibody-positive sera.
Inflammatory myopathy, bronchiolitis obliterans/organizing pneumonia, and anti-Jo-1 antibodies--an interesting association.
Involvement of NK Cells and NKp30 Pathway in Antisynthetase Syndrome.
Jo-1 autoantigen-specific B cells are skewed towards distinct functional B cell subsets in anti-synthetase syndrome patients.
Lung Diseases in Inflammatory Myopathies.
Oxygen-Dependent Patient with Antisynthetase Syndrome Associated Interstitial Lung Disease Responds Promptly to Rituximab with Rapid Pulmonary Function Improvement.
Pathogenic aspects of dermatomyositis, polymyositis and overlap myositis.
Patients with anti-Jo1 antibodies display a characteristic IgG Fc-glycan profile which is further enhanced in anti-Jo1 autoantibodies.
Prevalence of antibodies to Ro-52 in a serologically defined population of patients with systemic sclerosis.
Pulmonary complications of polymyositis and dermatomyositis.
Pulmonary Pathologic Manifestations of Anti-Alanyl-tRNA Synthetase (Anti-PL-12)-Related Inflammatory Myopathy.
Pulmonary pathologic manifestations of anti-glycyl-tRNA synthetase (anti-EJ)-related inflammatory myopathy.
Scleroderma overlap syndromes.
The pulmonary histopathologic manifestations of the anti-Jo-1 tRNA synthetase syndrome.
Toll like receptor-7/8 activation exacerbates murine experimental autoimmune myositis.
[Anti-Jo-1 antibody and anti-aminoacyl-tRNA synthetase antibody as a marker autoantibody for myositis]
[Antisynthetase syndromes].
[Autoantibodies specifically detected in patients with polymyositis/dermatomyositis]
[Clinical and pathological findings of patients with interstitial lung disease associated with antisynthetase]
[How can we diagnose and better understand inflammatory myopathies? The usefulness of auto-antibodies].
[Idiopathic Inflammatory Myopathy and Anti-aminoacyl-tRNA Synthetase Antibody].
[Myositis-related interstitial lung disease and antisynthetase syndrome.]
[Progress of Autoantibody Examinations for Connective Tissue Diseases].
[Pulmonary fibrosis as a presentation form of the Jo-1 syndrome]
[Two cases of polymyositis associated with interstitial pneumonia with anti-OJ (isoleucyl tRNA synthetase) antibodies]
Neoplasm Metastasis
Evading immune surveillance via tyrosine phosphorylation of nuclear PCNA.
Evaluation on serum 2'-5'oligoadenylate synthetase (2'-5'oligoAS) and beta 2 microglobulin (B2M) in patients with nodal metastases from cutaneous malignant melanoma treated with rIFN-alpha 2A.
Inhibition of tumor cell metastasis by modulation of the vascular prostacyclin/thromboxane A2 system.
Prostaglandin and thromboxane synthesis by M5076 ovarian reticulosarcoma during growth: effects of a thromboxane synthetase inhibitor.
Resistance of cyclooxygenase-2 expressing pancreatic ductal adenocarcinoma cells against ?? T cell cytotoxicity.
[Relationship between the anti-metastatic effect of UFT and in vitro chemosensitivity to 5-FU in metastatic tumors from orthotopic implanted colon cancer in nude rats]
Neoplasms
2',5'-oligoadenylate synthetase activity in human mammary tumors and its potential correlation with tumor growth or hormonal responsiveness.
2-Aminophenylpyrimidines as Novel Inhibitors of Aminoacyl-tRNA Synthetase Interacting Multifunctional Protein 2 (AIMP2)-DX2 for Lung Cancer Treatment.
5-Phosphoribosyl pyrophosphate synthetase from Ehrlich ascites tumor cells.
5-Substituted 2'-deoxyuridines: correlation between inhibition of tumor cell growth and inhibition of thymidine kinase and thymidylate synthetase.
A retrospective cohort study in Chinese patients with adult polymyositis and dermatomyositis: risk of comorbidities and subclassification using machine learning.
A translation independent function of PheRS/FARS activates growth and proliferation.
Aberration of poly(adenosine diphosphate-ribose) metabolism in human colon adenomatous polyps and cancers.
Action of interferon-alpha on hairy cell leukemia: expression of specific receptors and (2'-5')oligo (A) synthetase in tumor cells from sensitive and resistant patients.
Activation of histamine H4 receptor suppresses the proliferation and invasion of esophageal squamous cell carcinoma via both metabolism and non-metabolism signaling pathways.
Adoptive immunotherapy of human cancer: the cytokine cascade and monocyte activation following high-dose interleukin 2 bolus treatment.
ADP-ribosylation of chromosomal proteins and mouse mammary tumor virus gene expression. Glucocorticoids rapidly decrease endogenous ADP-ribosylation of nonhistone high mobility group 14 and 17 proteins.
AIMP2-DX2 Promotes the Proliferation, Migration, and Invasion of Nasopharyngeal Carcinoma Cells.
Alterations of hepatic delta-aminolevulinic acid synthetase, heme oxygenase, microsomal cytochrome content and drug metabolism in rats bearing ascitic tumors AH 13, AH 66 and AH 414 and a 3-methylcholanthrene induced tumor.
Ameliorative role of curcumin on copper oxide nanoparticles-mediated renal toxicity in rats: An investigation of molecular mechanisms.
Antioxidant enzymes in oligodendroglial brain tumors: association with proliferation, apoptotic activity and survival.
Antitumor agents XXVII: Effects of helenalin on anaerobic and aerobic metabolism of Ehrlich ascites cells.
Antitumoral action of interferon and poly(A)poly(U) on HeLa xenografts in the nude mouse.
Antiviral activity of tumour necrosis factor. Synergism with interferons and induction of oligo-2',5'-adenylate synthetase.
Arginine Deiminase Enzyme Evolving As A Potential Antitumor Agent.
Biochemical determinants of responsiveness to 5-fluorouracil and its derivatives in xenografts of human colorectal adenocarcinomas in mice.
Biomarkers for cetuximab-based neoadjuvant radiochemotherapy in locally advanced rectal cancer.
Cancer Association Study of Aminoacyl-tRNA Synthetase Signaling Network in Glioblastoma.
Cancer-associated splicing variant of tumor suppressor AIMP2/p38: pathological implication in tumorigenesis.
Cancer-Specific Production of N-Acetylaspartate via NAT8L Overexpression in Non-Small Cell Lung Cancer and Its Potential as a Circulating Biomarker.
Carbonic anhydrase IX in oligodendroglial brain tumors.
Changes in biomarker expression in the development of prostatic adenocarcinoma.
Cholesterol Synthetase DHCR24 Induced by Insulin Aggravates Cancer Invasion and Progesterone Resistance in Endometrial Carcinoma.
Clinical value of the determination of an interferon-induced enzyme activity: studies of the 2'5' oligoadenylate synthetase activity in peripheral blood lymphocytes of patients.
Collagen metabolism as a regulator of proline dehydrogenase/proline oxidase-dependent apoptosis/autophagy.
Control of -aminolevulinic acid synthetase and tyrosine aminotransferase in tumors and livers of tumor-bearing rats.
Control of leucine-dependent mTORC1 pathway through chemical intervention of leucyl-tRNA synthetase and RagD interaction.
Control of pyrimidine biosynthesis in mammalian tissues. II. Glutamine-utilizing carbamoyl phosphate synthetase of various experimental tumors: distribution, purification and characterization.
Counter-regulation of opioid analgesia by glial-derived bioactive sphingolipids.
Depression in gene expression for poly(ADP-ribose) synthetase during the interferon-gamma-induced activation process of murine macrophage tumor cells.
Determination of three-dimensional structure and residues of the novel tumor suppressor AIMP3/p18 required for the interaction with ATM.
Development and therapeutic options for the treatment of raloxifene-stimulated breast cancer in athymic mice.
Development of a chemoresistant orthotopic human nonsmall cell lung carcinoma model in nude mice: analyses of tumor heterogenity in relation to the immunohistochemical levels of expression of cyclooxygenase-2, ornithine decarboxylase, lung-related resistance protein, prostaglandin E synthetase, and glutathione-S-transferase-alpha (GST)-alpha, GST-mu, and GST-pi.
Dichlorodiphenyldichloroethylene exposure reduces r-GCS via suppressed Nrf2 in HepG2 cells.
Dietary alpha-linolenic acid reduces COX-2 expression and induces apoptosis of hepatoma cells.
Differences in total mitochondrial proteins and proteins synthesized by mitochondria from rat liver and Morris hepatomas 9618A, 5123C, and 5123tc.
Direct action of interferon and inducers of interferon on tumor cells in athymic nude mice.
Discovery of novel tRNA-amino acid dual-site inhibitors against threonyl-tRNA synthetase by fragment-based target hopping.
DNA fragmentation and NAD depletion. Their relation to the turnover of endogenous mono(ADP-ribosyl) and poly(ADP-ribosyl) proteins.
DNA strand breaks and poly(ADP-ribose) synthetase activation in pancreatic islets--a new aspect to development of insulin-dependent diabetes and pancreatic B-cell tumors.
Do NSAIDs exert their colon cancer chemoprevention activities through the inhibition of mucosal prostaglandin synthetase?
Downregulation of lamin A by tumor suppressor AIMP3/p18 leads to a progeroid phenotype in mice.
Effect of alkylating agents on glycogen synthetase activity of ascites tumor cells.
Effect of interleukin-2 on some micronutrients during adoptive immunotherapy for various cancers.
Effect of select medium supplements on in vitro development of Cryptosporidium andersoni in HCT-8 cells.
Effects of intravenous infusion of trans-10, cis-12 18:2 on mammary lipid metabolism in lactating dairy cows.
Effects of thromboxane A2 inhibition on osteogenic sarcoma cell-induced platelet aggregation.
Enhancement of glutathione and g-glutamylcysteine synthetase, the rate limiting enzyme of glutathione synthesis, by chemoprotective plant-derived food and beverage components in the human hepatoma cell line HepG2.
Enhancement of the innate and cellular immune response in patients with genital warts treated with topical imiquimod cream 5%.
Estrogen represses Hepatocellular Carcinoma (HCC) growth via inhibiting alternative activation of tumor-associated macrophages (TAMs).
Evaluation of 2-(3-aminobenzamido)-2-deoxy-D-glucose as a radiosensitizer.
Evaluation of biomarker modulation by fenretinide in prostate cancer patients.
Evaluation of endogenous acidic metabolic products associated with carbohydrate metabolism in tumor cells.
Evaluation of thioesterase II as a serum marker for rat mammary cancer.
Evolution of the multi-tRNA synthetase complex and its role in cancer.
Expression of Lipid Metabolism-Related Proteins Differs between Invasive Lobular Carcinoma and Invasive Ductal Carcinoma.
Factors that influence the therapeutic activity of 5-fluorouracil [6RS]leucovorin combinations in colon adenocarcinoma xenografts.
Fatty acid synthetase and its mRNA are induced by progestins in breast cancer cells.
Fatty acid synthetase from a mouse mammary adenocarcinoma.
Folylpoly-?-glutamate synthetase: A key determinant of folate homeostasis and antifolate resistance in cancer.
Folylpoly-Glutamate Synthetase Expression Is Associated with Tumor Response and Outcome from Pemetrexed-Based Chemotherapy in Malignant Pleural Mesothelioma.
Gene expression signature of primary imatinib-resistant chronic myeloid leukemia patients.
Gene therapy for head and neck cancer using vaccinia virus expressing IL-2 in a murine model, with evidence of immune suppression.
Genome-wide CRISPR/Cas9 knockout screening uncovers a novel inflammatory pathway critical for resistance to arginine-deprivation therapy.
Glucocorticoid agonists as well as antagonists are effective inducers of mouse mammary tumor virus RNA in mouse mammary tumor cells treated with inhibitors of ADP-ribosylation.
Glucocorticoid receptor knockdown decreases the antioxidant protection of B16 melanoma cells: an endocrine system-related mechanism that compromises metastatic cell resistance to vascular endothelium-induced tumor cytotoxicity.
Glutathione S-transferase-P1 expression correlates with increased antioxidant capacity in transitional cell carcinoma of the urinary bladder.
Green Tea Polyphenols Ameliorate Pancreatic Injury in Cerulein-Induced Murine Acute Pancreatitis.
Guanosine-5'-phosphate synthetase and guanosine-5'-phosphate kinase in rat hepatomas and kidney tumors.
Heme regulation in mouse mammary carcinoma and liver of tumor bearing mice--I. Effect of allyl-isopropylacetamide and veronal on delta-aminolevulinate synthetase, cytochrome P-450 and cytochrome oxidase.
Heparan sulfation is essential for the prevention of cellular senescence.
Heterogeneous nuclear RNA from hairy cell leukemia patients activates 2',5'-oligoadenylate synthetase.
High throughput proteomic and metabolic profiling identified target correction of metabolic abnormalities as a novel therapeutic approach in head and neck paraganglioma.
Human lung cancer nodules in organotypic culture: no evidence of correlation between the antiproliferative effects of interferons and the induction of 2',5'-oligoadenylate synthetase.
Human lymphoblastoid interferon. In vitro and in vivo studies in hepatocellular carcinoma.
Identification of a third form of glycogen synthetase in rat chloroma tumors.
Immunological Microenvironment Predicts the Survival of the Patients with Hepatocellular Carcinoma Treated with Anti-PD-1 Antibody.
In vitro inhibition of cytidine triphosphate synthetase activity by cyclopentenyl cytosine in paediatric acute lymphocytic leukaemia.
In vivo and in vitro induction of (2'-5') oligoadenylate synthetase by human interferons in leukocytes from healthy donors and patients with renal cancer and hairy cell leukemia.
In vivo induction of the interferon-stimulated protein 2'5'-oligoadenylate synthetase in tumor and peripheral blood cells during IFN-alpha treatment of metastatic melanoma.
Increased carbamoyl-phosphate synthetase II concentration in rat hepatomas: immunological evidence.
Induction of 2',5' oligo(A) synthetase in tumor-bearing mice with encephalomyocarditis (EMC) virus or poly(I)poly(C).
Induction of 2',5'-oligoadenylate synthetase activity in peripheral blood mononuclear cells by gamma interferon.
Induction of 2',5'-oligoadenylate synthetase in freshly separated malignant cells from solid tumors. Variability in the susceptibility of interferon.
Induction of 2',5'oligo (A) synthetase in animals bearing Ehrlich ascites tumor cells.
Induction of Apoptosis and Reduction of Endogenous Glutathione Level by the Ethyl-Acetate Soluble Fraction of the Methanol Extract of the Roots of Potentilla fulgens in Cancer Cells.
Induction of rat pancreatic B-cell tumors by the combined administration of streptozotocin or alloxan and poly(adenosine diphosphate ribose) synthetase inhibitors.
Inhibition of human HT29 colon carcinoma growth in vitro and in vivo by swainsonine and human interferon-alpha 2.
Inhibition of potentially lethal radiation damage repair in normal and neoplastic human cells by 3-aminobenzamide: an inhibitor of poly(ADP-ribosylation).
Inhibition of the phosphoribosyl-formylglycineamidine synthetase of Ehrlich ascites tumor cells by glutamine analogues.
Inhibition of tumor angiogenesis by a natural fragment of a tRNA synthetase.
Inhibitory mechanism of five natural flavonoids against murine norovirus.
Interferon gamma regulates a unique set of proteins in fresh human bladder transitional cell carcinomas.
Interferon, double-stranded RNA, and RNA degradation. Isolation of homogeneous pppA(2'p5'A)n-1 synthetase from Ehrlich ascites tumor cells.
Interferons, double-stranded RNA, and RNA degradation. Isolation and characterization of homogeneous human (2'-5')(a)n synthetase.
L-asparaginyl-tRNA synthetase and L-asparagine synthetase activities of L-asparaginase-sensitive and -resistant forms of the mouse Gardner lymphoma 6C3HED.
Label-free molecular probe based on G-quadruplex and strand displacement for sensitive and selective detection and naked eye discrimination of exon 2 deletion of AIMP2.
Levels of acyl-coenzyme A synthetase 5 in urothelial cells and corresponding neoplasias reflect cellular differentiation.
Lipid metabolism and enzyme activities in hormone-dependent and hormone-independent mammary adenocarcinoma in GR mice.
Long-term treatment of malignant gliomas with intramuscularly administered polyinosinic-polycytidylic acid stabilized with polylysine and carboxymethylcellulose: an open pilot study.
Major biocontrol of plant tumors targets tRNA synthetase.
Measurement of interferon sensitivity in tumour cells from fine-needle aspirations.
Metabolic pathways of L-arginine and therapeutic consequences in tumors.
Methotrexate analogues. 26. Inhibition of dihydrofolate reductase and folylpolyglutamate synthetase activity and in vitro tumor cell growth by methotrexate and aminopterin analogues containing a basic amino acid side chain.
miR-543 and miR-590-3p regulate human mesenchymal stem cell aging via direct targeting of AIMP3/p18.
Molecular basis and current strategies of therapeutic arginine depletion for cancer.
Molecular docking studies of flavonoids for their inhibition pattern against ?-catenin and pharmacophore model generation from experimentally known flavonoids to fabricate more potent inhibitors for Wnt signaling pathway.
Mouse mammary carcinoma porphobilinogenase and hydroxymethylbilane synthetase.
Multi-Omics Database Analysis of Aminoacyl-tRNA Synthetases in Cancer.
Mutations in the beta-catenin gene (CTNNB1) in endometrioid ovarian carcinomas.
N-terminus of pro-EMAP II regulates its binding with C-terminus, Arginyl-tRNA Synthetase, and Neurofilament light protein.
Nelumbo nucifera Leaves Prevent NMU-Induced Mammary Tumor through Downregulation of Fatty Acid Synthase, Estrogen Receptor-? and Her2 Expression.
Nitric oxide enhances PGI(2)production by human pulmonary artery smooth muscle cells.
Nitric oxide mediates natural polyphenol-induced Bcl-2 down-regulation and activation of cell death in metastatic B16 melanoma.
Nitric oxide promotes resistance to tumor suppression by CTLs.
Nitric Oxide: The Forgotten Child of Tumor Metabolism.
Novel mRNA isoforms and mutations of uridine monophosphate synthetase and 5-fluorouracil resistance in colorectal cancer.
Oncogenic Mutation of AIMP2/p38 Inhibits Its Tumor-Suppressive Interaction with Smurf2.
Opposite sensitivity to the antiproliferative action of interferon-alpha and granulocyte-macrophage colony-stimulating factor in monoblastic U937 cells.
Overcoming multidrug-resistance in cancer: statins offer a logical candidate.
Paeonia japonica, Houttuynia cordata, and Aster scaber water extracts induce nitric oxide and cytokine production by lipopolysaccharide-activated macrophages.
Papers of note in Nature542 (7641).
Participation of poly(ADP-ribose) synthetase in the process of norepinephrine-induced inhibition of major histocompatibility complex class II antigen expression in human astrocytoma cells.
Peroxisomal proliferators inhibit acyl CoA synthetase and stimulate protein kinase C in vivo.
Phase I/II trial of recombinant gamma-interferon in patients with renal cell carcinoma: immunologic and biologic effects.
Polyadenylic-polyuridylic acid: biological response-modifying activities in mice. In vivo organ distribution and pharmacokinetics in rabbits.
Progestin-induced fatty acid synthetase in human mammary tumors: from molecular to clinical studies.
Proliferation-linked increase in phosphoribosylformylglycinamidine synthetase activity (EC 6.3.5.3).
Prostaglandin and thromboxane synthesis by M5076 ovarian reticulosarcoma during growth: effects of a thromboxane synthetase inhibitor.
Purification and properties of phosphoribosyl-formylglycineamidine synthetase of ehrlich ascites tumor cells.
Rapid detection of exon 2-deleted AIMP2 mutation as a potential biomarker for lung cancer by molecular beacons.
Regulation of gene expression by insulin and tumor necrosis factor alpha in 3T3-L1 cells. Modulation of the transcription of genes encoding acyl-CoA synthetase and stearoyl-CoA desaturase-1.
Regulation of purine metabolism. Adenylosuccinate synthetase from Novikoff ascites tumor cells.
Regulatory properties and behavior of activity of carbamoyl phosphate synthetase II (glutamine-hydrolyzing) in normal and proliferating tissues.
Resistance of cyclooxygenase-2 expressing pancreatic ductal adenocarcinoma cells against ?? T cell cytotoxicity.
Response of L-1210 tumor in mice toward treatment with interferon or poly(I) X poly(C).
Rhodanese and ALA-S in mammary tumor and liver from normal and tumor-bearing mice.
Role for HER2/neu and HER3 in fulvestrant-resistant breast cancer.
Role of PRPS2 as a prognostic and therapeutic target in osteosarcoma.
Selective Labeling and Identification of the Tumor Cell Proteome of Pancreatic Cancer In Vivo.
Serine one-carbon catabolism with formate overflow.
Specific regulation of the 100 kDa 2-5 A synthetase by protein kinase C.
Spermatogonia-dependent expression of testicular genes in mice.
Structural characterization of antibiotic self-immunity tRNA synthetase in plant tumour biocontrol agent.
Studies on resistance against 5-fluorouracil. II. Thymidylate synthetase from drug-resistant tumor lines.
Studies on the activities of some methyltransferases in the livers and tumor cells from tumor-bearing mice.
Studies with pure mouse Ehrlich ascites tumor interferons alpha and beta: patterns of induction of (2'-5') (A)n synthetase and of a double-stranded RNA-dependent protein kinase in mouse cells and human cells.
Suppression of AIMP1 protects cognition in Alzheimer's disease model mice 3xTg-AD.
Synergistic effect of interferon-gamma and tumor necrosis factor-alpha on antiviral activity and (2'-5') oligo (A) synthetase induction in a myelomonocytic cell line.
Synthesis and catabolism of PGE2 by a nephroblastoma associated with hypercalcemia without bone metastases.
Synthesis of (2'-5')(A)n from ATP. Characteristics of the reaction catalyzed by (2'-5')(A)n synthetase purified from mouse Ehrlich ascites tumor cells treated with interferon.
Targeting the Vulnerability of Glutathione Metabolism in ARID1A-Deficient Cancers.
The action of interferon alpha on human carcinoid tumours.
The effect of pre-injection of mice with pristane on ascites tumour formation and monoclonal antibody production.
The effect of tumour growth on liver pantothenate, CoA, and fatty acid synthetase activity in the mouse.
The enzymes of glutathione synthesis: gamma-glutamylcysteine synthetase.
The influence of arachidonic acid metabolites on cell division in the intestinal epithelium and in colonic tumors.
The Role of the Glutathione System in Oxidative Modification of Proteins and Dysregulation of Apoptosis in Jurkat Tumor Cells.
TNF-induced activation of pulmonary microvessel endothelial cells: a role for GSK3beta.
Tumor endothelial cell tube formation model for determining anti-angiogenic activity of a tRNA synthetase cytokine.
Tumor hypoglycemia induced in nude mice by a heterotransplantable human ovarian carcinoma line (OCL-1).
Urea synthesis in Novikoff and Morris hepatomas.
Ursolic acid isolated from the seed of Cornus officinalis ameliorates colitis in mice by inhibiting the binding of lipopolysaccharide to Toll-like receptor 4 on macrophages.
Vnn1 pantetheinase limits the Warburg effect and sarcoma growth by rescuing mitochondrial activity.
White button mushroom phytochemicals inhibit aromatase activity and breast cancer cell proliferation.
[5-fluorouracil and colorectal tumors: use in clinical practice and the "MISURA" project]
[Cancer-associated alterations of glycoconjugates--special reference to glycosphingolipids]
[Detection of gene expression alteration of myeloma cells treated with arsenic trioxide]
[Hexosamine synthetase activity in the Walker tumor.]
[Immunophenotypic classification of 3 cases of hepatocellular adenoma. Differential diagnosis with focal nodular hyperplasia].
[Mode of action of fluoropyrimidines, in relation to their clinical application]
[On the potential protective properties of vitamin A in carcinogenesis]
[The effect of different types of recombinant interferon on the induction of 2,5-oligoadenylate synthetase in natural killers and the tumor cells in bladder cancer patients]
Nephritis
Antinephritic effect of OKY-046, a thromboxane A synthetase inhibitor (1). Effects on crescentic-type anti-GBM nephritis in rats.
Antinephritic effect of Y-19018, a thromboxane A synthetase inhibitor, on crescentic-type anti-GBM nephritis in rats.
Henoch-Schönlein purpura nephritis occurring postpartum in a patient with anti-PL-7 anti-synthetase syndrome.
Studies on antinephritic effect of TJ-8014, a new Japanese herbal medicine, and its mechanisms (2): Effect on the release of corticosterone from adrenal glands.
Nephrosis
Lipid metabolism in the aorta of daunomycin-induced nephrotic rats.
Nephrotic Syndrome
Clinical effects of selective thromboxane A2 synthetase inhibitor in patients with nephrotic syndrome.
Nervous System Autoimmune Disease, Experimental
Toll like receptor-7/8 activation exacerbates murine experimental autoimmune myositis.
Nervous System Diseases
Characterization of sleep in six patients with pantothenate kinase-associated neurodegeneration.
Clinical rating scale for pantothenate kinase-associated neurodegeneration: A pilot study.
Current state of knowledge in Chorea-Acanthocytosis as core Neuroacanthocytosis syndrome.
Deficient activity of alanyl-tRNA synthetase underlies an autosomal recessive syndrome of progressive microcephaly, hypomyelination, and epileptic encephalopathy.
Sensory Tricks in Pantothenate Kinase-Associated Neurodegeneration: Video-Analysis of 43 Patients.
Neural Tube Defects
MTHFD1 formyltetrahydrofolate synthetase deficiency, a model for the MTHFD1 R653Q variant, leads to congenital heart defects in mice.
Neuralgia
Cellular mechanisms of neuropathic pain, morphine tolerance, and their interactions.
Koumine enhances spinal cord 3?-hydroxysteroid oxidoreductase expression and activity in a rat model of neuropathic pain.
The inhibition of nitric oxide-activated poly(ADP-ribose) synthetase attenuates transsynaptic alteration of spinal cord dorsal horn neurons and neuropathic pain in the rat.
Neuroacanthocytosis
Current state of knowledge in Chorea-Acanthocytosis as core Neuroacanthocytosis syndrome.
Huntington's disease look-alikes.
Mineral deposition on magnetic resonance imaging in chorea-acanthocytosis: a pathogenic link with pantothenate kinase-associated neurodegeneration?
Neuroacanthocytosis in china: a review of published reports.
Neuroacanthocytosis: a case report of chorea-acanthocytosis.
Neurologic phenotypes associated with acanthocytosis.
Severe tongue protrusion dystonia: clinical syndromes and possible treatment.
The neuropsychiatry of neuroacanthocytosis syndromes.
Tongue Protrusion Dystonia in Pantothenate Kinase-Associated Neurodegeneration.
Untangling the Thorns: Advances in the Neuroacanthocytosis Syndromes.
Neuroaxonal Dystrophies
Consensus clinical management guideline for beta-propeller protein-associated neurodegeneration.
Deep brain stimulation in the globus pallidus compensates response inhibition deficits: evidence from pantothenate kinase-associated neurodegeneration.
Excess iron harms the brain: the syndromes of neurodegeneration with brain iron accumulation (NBIA).
Genetics and Pathophysiology of Neurodegeneration with Brain Iron Accumulation (NBIA).
Infantile neuroaxonal dystrophy and pantothenate-kinase-associated neurodegeneration: locus heterogeneity.
Iron Accumulation in Syndromes of Neurodegeneration with Brain Iron Accumulation 1 and 2 - causative or consequential?
Neurodegeneration with brain iron accumulation.
Neurodegeneration with brain iron accumulation: Characterization of clinical, radiological, and genetic features of pediatric patients from Southern India.
Pantothenate kinase-associated neurodegeneration (PKAN) and PLA2G6-associated neurodegeneration (PLAN): review of two major neurodegeneration with brain iron accumulation (NBIA) phenotypes.
Pathophysiology and treatment of neurodegeneration with brain iron accumulation in the pediatric population.
Syndromes of neurodegeneration with brain iron accumulation (NBIA): an update on clinical presentations, histological and genetic underpinnings, and treatment considerations.
T2* and FSE MRI distinguishes four subtypes of neurodegeneration with brain iron accumulation.
Treatment of Classic Pantothenate Kinase-Associated Neurodegeneration with Deferiprone and Intrathecal Baclofen.
Neuroblastoma
DNA (cytosine) methyltransferase overexpression is associated with acquired drug resistance of murine neuroblastoma cells.
Experimental chemotherapy of neuroblastoma. II. Increased thymidylate synthetase activity in a 5-fluorodeoxyuridine-resistant variant of mouse neuroblastoma.
Ganglioside GM2/GD2 synthetase mRNA is a marker for detection of infrequent neuroblastoma cells in bone marrow.
Retinoic acid reduces the cytotoxicity of cyclopentenyl cytosine in neuroblastoma cells.
[Evaluation of urinary excretion of free-cortisol in patients with abnormal pituitary-adrenal axes]
Neurodegenerative Diseases
A new in vivo model of pantothenate kinase-associated neurodegeneration reveals a surprising role for transcriptional regulation in pathogenesis.
A novel gene mutation in PANK2 in a patient with an atypical form of pantothenate kinase-associated neurodegeneration.
A novel PANK2 gene mutation: clinical and molecular characteristics of patients short communication.
A Scale to Assess Activities of Daily Living in Pantothenate Kinase-Associated Neurodegeneration.
A variation in PANK2 gene is causing Pantothenate kinase-associated Neurodegeneration in a family from Jammu and Kashmir - India.
Botulinum Toxin-A Injection in the Treatment of Spasticity in a Infantile-Onset Neurodegeneration With Brain Iron Accumulation: A Case Report.
Coenzyme A corrects pathological defects in human neurons of PANK2-associated neurodegeneration.
Consensus clinical management guideline for beta-propeller protein-associated neurodegeneration.
Cyclic Phosphopantothenic Acid Prodrugs for Treatment of Pantothenate Kinase-Associated Neurodegeneration.
Deep brain stimulation as treatment for dystonic storm in pantothenate kinase-associated neurodegeneration syndrome: case report of a patient with homozygous C.628 2 T?>?G mutation of the PANK2 gene.
Deficiency of pantothenate kinase 2 (Pank2) in mice leads to retinal degeneration and azoospermia.
Diagnostic and clinical experience of patients with pantothenate kinase-associated neurodegeneration.
Early-onset neurodegeneration with brain iron accumulation due to PANK2 mutation.
Etiology and treatment of adrenoleukodystrophy: new insights from Drosophila.
Identification and targeted management of a neurodegenerative disorder caused by biallelic mutations in SLC5A6.
Impaired Coenzyme A metabolism affects histone and tubulin acetylation in Drosophila and human cell models of pantothenate kinase associated neurodegeneration.
Lethal NARS2-Related Disorder Associated With Rapidly Progressive Intractable Epilepsy and Global Brain Atrophy.
Low-frequency rTMS of the premotor cortex reduces complex movement patterns in a patient with pantothenate kinase-associated neurodegenerative disease (PKAN).
Magnetic resonance imaging in pantothenate kinase-2-associated neurodegeneration.
Neuroacanthocytosis: a case report of chorea-acanthocytosis.
Neuropareidolia: diagnostic clues apropos of visual illusions.
Novel homozygous PANK2 mutation identified in a consanguineous Chinese pedigree with pantothenate kinase-associated neurodegeneration.
Overexpression of Human Mutant PANK2 Proteins Affects Development and Motor Behavior of Zebrafish Embryos.
Pantethine rescues a Drosophila model for pantothenate kinase-associated neurodegeneration.
Pantothenate kinase-associated neurodegeneration causing paradoxical vocal fold motion.
Peroxynitrite production and activation of poly (adenosine diphosphate-ribose) synthetase in spinal cord injury.
Role of iron in neurodegenerative disorders.
Siblings with the adult-onset slowly progressive type of pantothenate kinase-associated neurodegeneration and a novel mutation, Ile346Ser, in PANK2: clinical features and (99m)Tc-ECD brain perfusion SPECT findings.
Skin fibroblasts from pantothenate kinase-associated neurodegeneration patients show altered cellular oxidative status and have defective iron-handling properties.
The FOsmetpantotenate Replacement Therapy (FORT) randomized, double-blind, Placebo-controlled pivotal trial: Study design and development methodology of a novel primary efficacy outcome in patients with pantothenate kinase-associated neurodegeneration.
Vitamin B5 (d-pantothenic acid) localizes in myelinated structures of the rat brain: Potential role for cerebral vitamin B5 stores in local myelin homeostasis.
[Clinical characteristics and molecular pathogenesis of pantothenate kinase-associated neurodegenerative disease].
Neuroendocrine Tumors
Interferons in the management of neuroendocrine tumors and their possible mechanism of action.
Neuroinflammatory Diseases
Gedunin Inhibits Oligomeric A?1-42-Induced Microglia Activation Via Modulation of Nrf2-NF-?B Signaling.
Morphine Induces Apoptosis, Inflammation, and Mitochondrial Oxidative Stress via Activation of TRPM2 Channel and Nitric Oxide Signaling Pathways in the Hippocampus.
Neurologic Manifestations
Clinical consequences of enzyme deficiencies in the erythrocyte.
[Lethal neonatal deficiency of carbamyl phosphate synthetase (author's transl)]
Newcastle Disease
INHIBITION OF RIBONUCLEIC ACID SYNTHETASE FROM INFLUENZA- AND NEWCASTLE DISEASE VIRUS-INFECTED CELLS BY VARIOUS ANTIVIRAL COMPOUNDS.
Interferon inducibility and sensitivity of human teratocarcinoma-derived cell lines.
Nose Diseases
[THERAPEUTIC EFFECTIVENESS OF A NEW PREPARATION WITH A BASE OF MENTHYL PANTOTHENATE IN ACUTE AND CHRONIC NASAL DISEASES.]
Obesity
Effects of soy isoflavones on testosterone synthetase in diet-induced obesity male rats.
Experimental basis of obesity.
Inhibitors of VPS34 and lipid metabolism suppress SARS-CoV-2 replication.
Liver acetyl CoA carboxylase and fatty acid synthetase: relative activities in the normal state and in hereditary obesity.
Metabolic dysfunction in pregnancy: Fingerprinting the maternal metabolome using proton nuclear magnetic resonance spectroscopy.
Pathogenesis of obesity by food restriction in OLETF rats-increased intestinal monoacylglycerol acyltransferase activities may be a crucial factor.
Ultra-fast simultaneous detection of obesity-related coenzymes in mice using microchip electrophoresis with a LIF detector.
[Progress of researches on mechanisms of acupuncture therapy for insulin resistance].
Obesity, Abdominal
Abdominal obesity is associated with insulin resistance and reduced glycogen synthetase activity in skeletal muscle.
Obstetric Labor, Premature
Tocolytics for preterm labor: a systematic review.
Oligospermia
Phosphoribosyl-pyrophosphate synthetase 2 (PRPS2) depletion regulates spermatogenic cell apoptosis and is correlated with hypospermatogenesis.
Optic Atrophy
Optic Atrophy in a Patient With Atypical Pantothenate Kinase-Associated Neurodegeneration.
ornithine carbamoyltransferase deficiency
Citrulline in health and disease. Review on human studies.
Improving long term outcomes in urea cycle disorders-report from the Urea Cycle Disorders Consortium.
Isolation of Hepatic Progenitor Cells From Human Liver With Cirrhosis Secondary to Biliary Atresia Using EpCAM or Thy-1 Markers.
N-acetylglutamate content in liver and gut of normal and fasted mice, normal human livers, and livers of individuals with carbamyl phosphate synthetase or ornithine transcarbamylase deficiency.
Prenatal diagnosis of ornithine transcarbamylase deficiency utilizing fetal liver biopsy.
Urea Cycle Disorders: A Neuroimaging Pattern Approach Using Diffusion and FLAIR MRI.
Ornithine Carbamoyltransferase Deficiency Disease
Citrulline in health and disease. Review on human studies.
Improving long term outcomes in urea cycle disorders-report from the Urea Cycle Disorders Consortium.
Isolation of Hepatic Progenitor Cells From Human Liver With Cirrhosis Secondary to Biliary Atresia Using EpCAM or Thy-1 Markers.
N-acetylglutamate content in liver and gut of normal and fasted mice, normal human livers, and livers of individuals with carbamyl phosphate synthetase or ornithine transcarbamylase deficiency.
Prenatal diagnosis of ornithine transcarbamylase deficiency utilizing fetal liver biopsy.
The phenotypic spectrum of organic acidurias and urea cycle disorders. Part 1: the initial presentation.
Osteoarthritis
Degenerative knee joint disease in mice lacking 3'-phosphoadenosine 5'-phosphosulfate synthetase 2 (Papss2) activity: a putative model of human PAPSS2 deficiency-associated arthrosis.
Higher PGD2 production by synovial mast cells from rheumatoid arthritis patients compared with osteoarthritis patients via miR-199a-3p/prostaglandin synthetase 2 axis.
Osteolysis
Pharmaceutical inhibition of glycogen synthetase kinase 3 beta suppresses wear debris-induced osteolysis.
Osteoporosis
A Novel IFITM5 Variant Associated with Phenotype of Osteoporosis with Calvarial Doughnut Lesions: A Case Report.
Otitis Media
Host-derived sialic acid is incorporated into Haemophilus influenzae lipopolysaccharide and is a major virulence factor in experimental otitis media.
Ototoxicity
N-acetylcysteine and N-nitroarginine methyl ester attenuate Carboplatin-induced ototoxicity in dissociated spiral ganglion neuron cultures.
Ovarian Neoplasms
Rapid detection of exon 2-deleted AIMP2 mutation as a potential biomarker for lung cancer by molecular beacons.
Overweight
Efficacy of Slim339 in reducing body weight of overweight and obese human subjects.
Pancreatic Neoplasms
Evaluation of pyrimidine metabolising enzymes and in vitro uptake of 3'-[(18)F]fluoro-3'-deoxythymidine ([(18)F]FLT) in pancreatic cancer cell lines.
LAT2 regulates glutamine-dependent mTOR activation to promote glycolysis and chemoresistance in pancreatic cancer.
Metabolic effect of AOS-iron in rats with iron deficiency anemia using LC-MS/MS based metabolomics.
Pancreatitis
Green Tea Polyphenols Ameliorate Pancreatic Injury in Cerulein-Induced Murine Acute Pancreatitis.
Pancreatitis, Chronic
Release of hyaluronan and laminin into pancreatic secretions.
pantoate-beta-alanine ligase (amp-forming) deficiency
-Glutamyl-cysteine synthetase deficiency. A cause of hereditary hemolytic anemia.
?1 -Pyrroline-5-carboxylate synthetase deficiency: An emergent multifaceted urea cycle-related disorder.
A case of carbamyl phosphate synthetase deficiency.
A novel mouse model for genetic variation in 10-formyltetrahydrofolate synthetase exhibits disturbed purine synthesis with impacts on pregnancy and embryonic development.
Acute administration of 5-oxoproline induces oxidative damage to lipids and proteins and impairs antioxidant defenses in cerebral cortex and cerebellum of young rats.
Alteration of urinary carnitine profile induced by benzoate administration.
Aminoacyl-tRNA synthetase deficiencies in search of common themes.
Arginine deficiency syndrome. Its occurrence in carbamyl phosphate synthetase deficiency.
Arginosuccinate synthetase deficiency: good outcome despite severe neonatal hyperammonaemia.
Atypical phenylketonuria caused by 7, 8-dihydrobiopterin synthetase deficiency.
Atypical phenylketonuria due to dihydrobiopterin synthetase deficiency.
Augmenting ureagenesis in patients with partial carbamyl phosphate synthetase 1 deficiency with N-carbamyl-L-glutamate.
Autosomal recessive inheritance of human mitochondrial carbamyl phosphate synthetase deficiency.
Biallelic IARS Mutations Cause Growth Retardation with Prenatal Onset, Intellectual Disability, Muscular Hypotonia, and Infantile Hepatopathy.
Blood cell glycogen synthetase activities in hepatic glycogen synthetase deficiency.
Brain glutamine by MRS in a patient with urea cycle disorder and coma.
Carbamyl phosphate synthetase deficiency and postpartum hyperammonemia.
Carbamyl phosphate synthetase deficiency with lethal neonatal outcome.
Central tegmental tract involvement in an infant with 6-pyruvoyltetrahydropterin synthetase deficiency.
Cerebral Vitamin B5 (D-Pantothenic Acid) Deficiency as a Potential Cause of Metabolic Perturbation and Neurodegeneration in Huntington's Disease.
Citrullinemia: prenatal diagnosis of an affected fetus.
Clinical consequences of enzyme deficiencies in the erythrocyte.
Correction of congenital erythropoietic porphyria by bone marrow transplantation.
Correction to: Correspondence on "AminoacyltRNA synthetase deficiencies in search of common themes" by Fuchs et al.
Correction: Aminoacyl-tRNA synthetase deficiencies in search of common themes.
Correspondence on "Aminoacyl-tRNA synthetase deficiencies in search of common themes" by Fuchs et al.
Disorders associated with purine and pyrimidine metabolism.
Disorders of purine and pyrimidine metabolism.
Early liver transplantation in neonatal-onset and moderate urea cycle disorders may lead to normal neurodevelopment.
Effect of malnutrition on susceptibility of rats to Trypanosoma cruzi. III. Pantothenate deficiency.
Effect of pantothenate deficiency on synthesis of adrenal cholesterol following stress.
Glucose homeostasis in adulthood and in pregnancy in a patient with hepatic glycogen synthetase deficiency.
Hemolytic anemia, recurrent metabolic acidosis, and incomplete albinism associated with glutathione synthetase deficiency.
Hepatic glycogen synthetase deficiency not expressed in cultured skin fibroblasts.
Hepatic glycogen synthetase deficiency.
Hepatic glycogen synthetase deficiency. Definition of syndrome from metabolic and enzyme studies on a 9-year-old girl.
Hepatic glycogen synthetase deficiency. Further studies on a family.
Lipoic acid synthetase deficiency causes neonatal-onset epilepsy, defective mitochondrial energy metabolism, and glycine elevation.
Long-term management of a case of carbamyl phosphate synthetase deficiency using ketanalogues and hydroxyanalogues of essential amino acids.
Low Dietary Folate Interacts with MTHFD1 Synthetase Deficiency in Mice, a Model for the R653Q Variant, to Increase Incidence of Developmental Delays and Defects.
Metabolic stroke in carbamyl phosphate synthetase deficiency.
Metabolism of nicotinic acid under normal conditions and in pantothenate deficiency, studied in the rat.
Methionine supplementation for multi-organ dysfunction in MetRS-related pulmonary alveolar proteinosis.
Mild pantothenate deficiency in rats elevates serum triglyceride and free fatty acid levels.
MTHFD1 formyltetrahydrofolate synthetase deficiency, a model for the MTHFD1 R653Q variant, leads to congenital heart defects in mice.
N-acetyl-glutamate synthetase deficiency or porto-systemic shunt associated encephalopathy?
Neonatal death due to carbamyl phosphate synthetase deficiency.
Neonatal hyperphenylalaninaemia presumably caused by a new variant of biopterin synthetase deficiency.
Normal N-acetylglutamate concentration measured in liver from a new patient with N-acetylglutamate synthetase deficiency: physiologic and biochemical implications.
Nutritional therapy for selected inborn errors of metabolism.
Orthotopic liver transplantation in a patient with carbamyl phosphate synthetase deficiency and cystic fibrosis.
Pantothenic acid in health and disease.
Partial carbamyl phosphate synthetase deficiency, simulating Reye's syndrome, in a 9-year-old girl.
Partial N-acetyl-glutamate synthetase deficiency masquerading as a valproic acid-induced Reye-like syndrome.
Patients with genetic defects in the gamma-glutamyl cycle.
Phenotypes and genotypes of mitochondrial aminoacyl-tRNA synthetase deficiencies from a single neurometabolic clinic.
Phenylacetylglutamine may replace urea as a vehicle for waste nitrogen excretion.
Pilot use of the early motor repertoire in infants with inborn errors of metabolism: Outcomes in early and middle childhood.
Postpartum "psychosis" in mild argininosuccinate synthetase deficiency.
Proceedings: Hepatic ultrastructure in a child with carbamyl phosphate synthetase deficiency, hyperornithinaemia, hyperammonaemia, and homocitrullinuria.
Prospective cohort study for identification of underlying genetic causes in neonatal encephalopathy using whole-exome sequencing.
Prospective versus clinical diagnosis and therapy of acute neonatal hyperammonaemia in two sisters with carbamyl phosphate synthetase deficiency.
Pterin metabolism in normal subjects and hyperphenylalaninaemic patients.
Pterins analysis in amniotic fluid for the prenatal diagnosis of GTP cyclohydrolase deficiency.
Resistance of rats to inoculation with Corynebacterium pathogenic in pantothenate deficiency.
Serotonin and dopamine synthesis in phenylketonuria.
Severe Neonatal Manifestations of Infantile Liver Failure Syndrome Type 1 Caused by Cytosolic Leucine-tRNA Synthetase Deficiency.
Significance of pantothenate for glucose fermentation by Oenococcus oeni and for suppression of the erythritol and acetate production.
The dietary treatment of hepatic glycogen synthetase deficiency.
The effect of pantothenate deficiency in mice on their metabolic response to fast and exercise.
The effect of pantothenate deficiency on Trypanosoma lewisi infection in the rat.
The effects of pantothenate deficiency and acetate addition on anaerobic batch fermentation of glucose by Saccharomyces cerevisiae.
The first successful live birth following preimplantation genetic diagnosis using PCR for type 1 citrullinemia.
The phenotypic spectrum of organic acidurias and urea cycle disorders. Part 1: the initial presentation.
The radiographic signs of fatty liver.
Treatment of carbamyl phosphate synthetase deficiency with keto analogues of essential amino acids.
Urea Cycle Disorders: A Neuroimaging Pattern Approach Using Diffusion and FLAIR MRI.
Valproate-induced hyperammonemia.
[A case of citrullinemia associated with isolated ACTH deficiency, rapidly developing coma]
[A new inherited metabolic disease: delta1-pyrroline 5-carboxylate synthetase deficiency]
[Adrenal cortex functional activity in pantothenate deficiency and the administration of the vitamin or its derivatives]
[Congenital hyperammoniemia caused by ornithine carbamoyl-transferase and carbamyl phosphate synthetase deficiency]
[Diagnosis of deficiency in cofactor of phenylalanine hydroxylase: a metabolic emergency]
[Glycogenosis with probable glycogen synthetase deficiency in a 4-year-old boy]
[Hepatic glycogen synthetase deficiency or glycogen storage disease-zero. Mild phenotype with partial enzymatic defect]
[Hyperammonemia: partial carbamyl phosphate synthetase deficiency]
[Lethal neonatal deficiency of carbamyl phosphate synthetase (author's transl)]
[Liver coma with fatal course in 2 children under long-term antiepileptic therapy]
[Malignant phenylketonuria caused by biopterin synthetase deficiency. Study of neuromediator catabolites in the cerebrospinal fluid during treatment]
[Prenatal diagnosis of carbamyl phosphate synthetase deficiency by fetal liver biopsy]
[Remarks on a clinical case of partial carbamyl phosphate synthetase deficiency]
[Screening for newborn organic aciduria in Zhejiang province:prevalence, outcome and follow-up].
[The separate and combined effects of calcium pantothenate deficiency and cadmium intoxication on rat reproductive function].
[Therapy of hyperammonemia in carbamyl phosphate synthase deficiency with peritoneal dialysis and venovenous hemofiltration]
[Three congenital metabolic diseases in the Faeroe Islands. Incidence, clinical and molecular genetic characteristics of Faeroese children with glycogen storage disease type IIIA, carnitine transporter deficiency and holocarboxylase synthetase deficiency]
[Trial of indirect screening of tetrahydrobiopterin deficiency]
Pantothenate Kinase-Associated Neurodegeneration
123I-ioflupane SPECT findings of pantothenate kinase-associated neurodegeneration.
4'-Phosphopantetheine corrects CoA, iron, and dopamine metabolic defects in mammalian models of PKAN.
A new in vivo model of pantothenate kinase-associated neurodegeneration reveals a surprising role for transcriptional regulation in pathogenesis.
A novel 3-bp deletion in the PANK2 gene of Dutch patients with pantothenate kinase-associated neurodegeneration: evidence for a founder effect.
A novel gene mutation in PANK2 in a patient with an atypical form of pantothenate kinase-associated neurodegeneration.
A novel gene mutation in PANK2 in a patient with severe jaw-opening dystonia.
A novel homozygous variation in the PANK2 gene in two Persian siblings with atypical pantothenate kinase associated neurodegeneration.
A novel mutation in a patient with pantothenate kinase-associated neurodegeneration.
A Novel Nonsense Mutation in PANK2 Gene in Two Patients with Pantothenate Kinase-Associated Neurodegeneration.
A novel PANK2 gene mutation: clinical and molecular characteristics of patients short communication.
A novel PANK2 mutation in a 12-year-old Chinese boy with pantothenate kinase-associated neurodegeneration.
A patient with pantothenate kinase-associated neurodegeneration and supranuclear gaze palsy.
A pilot trial of deferiprone for neurodegeneration with brain iron accumulation.
A pilot trial of deferiprone in pantothenate kinase-associated neurodegeneration patients.
A Scale to Assess Activities of Daily Living in Pantothenate Kinase-Associated Neurodegeneration.
A variation in PANK2 gene is causing Pantothenate kinase-associated Neurodegeneration in a family from Jammu and Kashmir - India.
Abnormal Vasculature Development in Zebrafish Embryos with Reduced Expression of Pantothenate Kinase 2 Gene.
Acanthocytosis and the c.680 A>G Mutation in the PANK2 Gene: A Study Enrolling a Cohort of PKAN Patients from the Dominican Republic.
Aceruloplasminemia: Neurodegeneration with Brain Iron Accumulation (NBIA) associated with psychosis.
All that glitters is not gold: When motor and vocal tics in a child do not match Tourette syndrome: A case report.
Amantadine for Gait Dysfunction in Pantothenate Kinase-Associated Neurodegeneration.
Amelioration of Dystonic Opisthotonus in Pantothenate Kinase-Associated Neurodegeneration Syndrome with Absent "Eye-of-the-Tiger" Sign Following Bilateral Pallidal Deep Brain Stimulation.
An isoform of hPANK2, deficient in pantothenate kinase-associated neurodegeneration, localizes to mitochondria.
Anticholinergic-responsive gait freezing in a patient with pantothenate kinase-associated neurodegeneration.
Atypical pantothenate kinase-associated neurodegeneration with novel genetic mutation.
Atypical pantothenate kinase-associated neurodegeneration with PANK2 mutations : clinical description and a review of the literature.
Atypical pantothenate kinase-associated neurodegeneration with variable phenotypes in an Egyptian family.
Atypical pantothenate kinase-associated neurodegeneration: Clinical description of two brothers and a review of the literature.
Basal ganglia calcification and novel compound heterozygous mutations in the PANK2 gene in a Chinese boy with classic Pantothenate kinase-associated neurodegeneration: A case report.
Beta-propeller protein-associated neurodegeneration (BPAN), a rare form of NBIA: Novel mutations and neuropsychiatric phenotype in three adult patients.
Biochemical properties of human pantothenate kinase 2 isoforms and mutations linked to pantothenate kinase-associated neurodegeneration.
Botulinum toxin in the treatment of sialorrhea.
Botulinum toxin injection to improve functional independence and to alleviate parenting stress in a child with advanced pantothenate kinase-associated neurodegeneration: A case report and literature review.
Botulinum Toxin-A Injection in the Treatment of Spasticity in a Infantile-Onset Neurodegeneration With Brain Iron Accumulation: A Case Report.
Cannabis Use in Children With Pantothenate Kinase-Associated Neurodegeneration.
Cerebral blood flow in dystonia due to pantothenate kinase-associated neurodegeneration.
Changes in Cerebral Gray and White Matter in Patients with Pantothenate Kinase-Associated Neurodegeneration: A Long-Term Magnetic Resonance Imaging Follow-Up Study.
Changes in Red Blood Cell membrane lipid composition: A new perspective into the pathogenesis of PKAN.
Changes of cerebral white matter in patients suffering from Pantothenate Kinase-Associated Neurodegeneration (PKAN): A diffusion tensor imaging (DTI) study.
Characteristic "Forcible" Geste Antagoniste in Oromandibular Dystonia Resulting From Pantothenate Kinase-Associated Neurodegeneration.
Characterization of sleep in six patients with pantothenate kinase-associated neurodegeneration.
Characterization of the human PANK2 promoter.
Chasing shadows: What determines DTI metrics in gray matter regions? An in vitro and in vivo study.
Childhood disorders of neurodegeneration with brain iron accumulation (NBIA).
Clinical and genetic features of PKAN patients in a tertiary centre in Turkey.
Clinical and molecular research of neuroacanthocytosis.
Clinical and neuropsychological correlates in two brothers with pantothenate kinase-associated neurodegeneration.
Clinical course of patients with pantothenate kinase-associated neurodegeneration (PKAN) before and after DBS surgery.
CLINICAL EFFECT OF A MUTATION (p.Glu322Asp, c.966 G>T) IN PANK2 GENE IN A FAMILY WITH ATYPICAL PANTOTHENATE KINASE-ASSOCIATED NEURODEGENERATION.
Clinical Heterogeneity of Atypical Pantothenate Kinase-Associated Neurodegeneration in Koreans.
Clinical heterogeneity of neurodegeneration with brain iron accumulation (Hallervorden-Spatz syndrome) and pantothenate kinase-associated neurodegeneration.
Clinical rating scale for pantothenate kinase-associated neurodegeneration: A pilot study.
Clinical, imaging, and molecular findings in a sample of Mexican families with pantothenate kinase associated neurodegeneration.
Coenzyme A corrects pathological defects in human neurons of PANK2-associated neurodegeneration.
Consensus clinical management guideline for beta-propeller protein-associated neurodegeneration.
Consensus clinical management guideline for pantothenate kinase-associated neurodegeneration (PKAN).
Copper, Iron, and Manganese Toxicity in Neuropsychiatric Conditions.
Current state of knowledge in Chorea-Acanthocytosis as core Neuroacanthocytosis syndrome.
Cyclic Phosphopantothenic Acid Prodrugs for Treatment of Pantothenate Kinase-Associated Neurodegeneration.
De novo CoA biosynthesis is required to maintain DNA integrity during development of the Drosophila nervous system.
Declining Use of the Hallervorden-Spatz Disease Eponym in the Last Two Decades.
Decreasing iron neurotoxicity in pantothenate kinase-associated neurodegeneration.
Deep brain stimulation as a mode of treatment of early onset pantothenate kinase-associated neurodegeneration.
Deep brain stimulation as treatment for dystonic storm in pantothenate kinase-associated neurodegeneration syndrome: case report of a patient with homozygous C.628 2 T?>?G mutation of the PANK2 gene.
Deep brain stimulation for dystonia: a meta-analysis.
Deep brain stimulation for pantothenate kinase-associated neurodegeneration.
Deep brain stimulation for pantothenate kinase-associated neurodegeneration: A meta-analysis.
Deep brain stimulation improves quality of life in pantothenate kinase-associated neurodegeneration.
Deep brain stimulation in the globus pallidus compensates response inhibition deficits: evidence from pantothenate kinase-associated neurodegeneration.
Deep brain stimulation in the management of pantothenate kinase-associated neurodegeneration: A missed or a new target?
Deficiency of pantothenate kinase 2 (Pank2) in mice leads to retinal degeneration and azoospermia.
Dental appliance therapy in pantothenate kinase-associated neurodegeneration: Case report.
Deprivation of pantothenic acid elicits a movement disorder and azoospermia in a mouse model of pantothenate kinase-associated neurodegeneration.
Diagnostic and clinical experience of patients with pantothenate kinase-associated neurodegeneration.
Disorders of phospholipids, sphingolipids and fatty acids biosynthesis: toward a new category of inherited metabolic diseases.
Down regulation of the expression of mitochondrial phosphopantetheinyl-proteins in pantothenate kinase-associated neurodegeneration: pathophysiological consequences and therapeutic perspectives.
Early-onset neurodegeneration with brain iron accumulation due to PANK2 mutation.
Efficacy and safety of deferiprone for the treatment of pantothenate kinase-associated neurodegeneration (PKAN) and neurodegeneration with brain iron accumulation (NBIA): Results from a four years follow-up.
Electrophysiological assessment of the effect of intrathecal baclofen in dystonic children.
Emerging Disease-Modifying Therapies in Neurodegeneration With Brain Iron Accumulation (NBIA) Disorders.
Erratum to: Transcranial sonography in pantothenate kinase-associated neurodegeneration.
Erratum: A new in vivo model of pantothenate kinase-associated neurodegeneration reveals a surprising role for transcriptional regulation in pathogenesis.
Excess iron harms the brain: the syndromes of neurodegeneration with brain iron accumulation (NBIA).
Exploring Yeast as a Study Model of Pantothenate Kinase-Associated Neurodegeneration and for the Identification of Therapeutic Compounds.
Eye of the Tiger Sign in Pantothenate Kinase-Associated Neurodegeneration.
Eye-of-the-tiger Sign in Neurodegeneration with Brain Iron Accumulation.
Eye-of-the-Tiger sign is not Pathognomonic of Pantothenate Kinase-Associated Neurodegeneration in Adult Cases.
First cases in the Czech Republic of the Hallervorden-Spatz disease resulting from mutation in the pantothenate kinase 2 gene.
First report of co-morbidity of pantothenate kinase-associated neurodegeneration and three types of chronic hemolytic anemias.
First successful trial of preimplantation genetic diagnosis for pantothenate kinase-associated neurodegeneration.
Fosmetpantotenate (RE-024), a phosphopantothenate replacement therapy for pantothenate kinase-associated neurodegeneration: Mechanism of action and efficacy in nonclinical models.
Fosmetpantotenate Randomized Controlled Trial in Pantothenate Kinase-Associated Neurodegeneration.
Gene symbol: PANK2. Disease: Pantothenate kinase associated neurodegeneration (PKAN).
Gene symbol: PANK2. Disease: pantothenate kinase-associated neurodegeneration (PKAN).
Genetic heterogeneity in patients with pantothenate kinase-associated neurodegeneration and classic magnetic resonance imaging eye-of-the-tiger pattern.
Genetic, clinical, and imaging characterization of one patient with late-onset, slowly progressive, pantothenate kinase-associated neurodegeneration.
Genetic, clinical, and radiographic delineation of Hallervorden-Spatz syndrome.
Genetics and Pathophysiology of Neurodegeneration with Brain Iron Accumulation (NBIA).
Grey matter alterations in patients with Pantothenate Kinase-Associated Neurodegeneration (PKAN).
Hallervorden-Spatz Syndrome with Seizures.
Harmful Iron-Calcium Relationship in Pantothenate kinase Associated Neurodegeneration.
HARP syndrome is allelic with pantothenate kinase-associated neurodegeneration.
Huntington's disease look-alikes.
Idiopathic Basal Ganglia Calcifications: An Atypical Presentation of PKAN.
Impaired Coenzyme A metabolism affects histone and tubulin acetylation in Drosophila and human cell models of pantothenate kinase associated neurodegeneration.
Inborn errors of coenzyme A metabolism and neurodegeneration.
Induction of Neuron-Specific Degradation of Coenzyme A Models Pantothenate Kinase-Associated Neurodegeneration by Reducing Motor Coordination in Mice.
Infantile neuroaxonal dystrophy and pantothenate-kinase-associated neurodegeneration: locus heterogeneity.
Influence of the Plant Extract Complex "AdMax" on Global Gene Expression Levels in Cultured Human Fibroblasts.
Intellectual and adaptive behaviour functioning in pantothenate kinase-associated neurodegeneration.
Intellectual Disability, Falls and Gait Disturbances: A Misdiagnosis.
Involvement of Globus Pallidus and Midbrain Nuclei in Pantothenate Kinase-Associated Neurodegeneration : Measurement of T2 and T2* Time.
Iron Accumulation in Syndromes of Neurodegeneration with Brain Iron Accumulation 1 and 2 - causative or consequential?
Iron chelation in pantothenate kinase-associated neurodegeneration: A possible new avenue for slowing down disease progression in neurodegeneration.
Iron chelation in the treatment of neurodegenerative diseases.
Iron-related MRI images in patients with pantothenate kinase-associated neurodegeneration (PKAN) treated with deferiprone: Results of a phase II pilot trial.
Long-lasting isolated freezing of gait with good response to methylphenidate: A patient with pantothenate kinase-associated neurodegeneration.
Long-term benefit to pallidal deep brain stimulation in a case of dystonia secondary to pantothenate kinase-associated neurodegeneration.
Looking Deep into the Eye-of-the-Tiger in Pantothenate Kinase-Associated Neurodegeneration.
Magnetic resonance imaging pattern recognition in childhood bilateral basal ganglia disorders.
Magnetic resonance imaging, susceptibility weighted imaging and quantitative susceptibility mapping findings of pantothenate kinase-associated neurodegeneration.
Management of status dystonicus: our experience and review of the literature.
Measurement of brain iron distribution in Hallevorden-Spatz syndrome.
Metabolic consequences of mitochondrial coenzyme A deficiency in patients with PANK2 mutations.
Metabolism and energy requirements in pantothenate kinase-associated neurodegeneration.
Missense PANK2 mutation without "Eye of the tiger" sign: MR findings in a large group of patients with pantothenate kinase-associated neurodegeneration (PKAN).
Mitochondrial iron and energetic dysfunction distinguish fibroblasts and induced neurons from pantothenate kinase-associated neurodegeneration patients.
Mitochondrial localization of human PANK2 and hypotheses of secondary iron accumulation in pantothenate kinase-associated neurodegeneration.
Movement disorders in mitochondrial diseases.
MR relaxometry and 1H MR spectroscopy for the determination of iron and metabolite concentrations in PKAN patients.
MRI, MR spectroscopy, and diffusion tensor imaging findings in patient with static encephalopathy of childhood with neurodegeneration in adulthood (SENDA).
Mutations in the pantothenate kinase gene PANK2 are not associated with Parkinson disease.
Natural history and genotype-phenotype correlation of pantothenate kinase-associated neurodegeneration.
Neuro-ophthalmologic and electroretinographic findings in pantothenate kinase-associated neurodegeneration (formerly Hallervorden-Spatz syndrome).
Neuroacanthocytosis in china: a review of published reports.
Neuroacanthocytosis syndromes.
Neuroacanthocytosis.
Neuroacanthocytosis: a case report of chorea-acanthocytosis.
Neurodegeneration with brain iron accumulation in an eleven-year-old jamaican male.
Neurodegeneration with brain iron accumulation.
Neurodegeneration with brain iron accumulation: A case report.
Neurodegeneration with brain iron accumulation: A cautionary tale.
Neurodegeneration with brain iron accumulation: Characterization of clinical, radiological, and genetic features of pediatric patients from Southern India.
Neurologic phenotypes associated with acanthocytosis.
Neuromodulation for neurodegenerative conditions.
Neuromodulation in dystonia: current aspects of deep brain stimulation.
Neuronal Ablation of CoA Synthase Causes Motor Deficits, Iron Dyshomeostasis, and Mitochondrial Dysfunctions in a CoPAN Mouse Model.
Neuropathology and pathogenesis of extrapyramidal movement disorders: a critical update-I. Hypokinetic-rigid movement disorders.
Neuropsychological functions and psychiatric symptoms in late-onset manifestation of pantothenate kinase-associated neurodegeneration: a clinical case report.
New Perspectives in Iron Chelation Therapy for the Treatment of Neurodegenerative Diseases.
Nigropallidal iron accumulation in pantothenate kinase-associated neurodegeneration demonstrated by susceptibility-weighted imaging.
Novel compound heterozygous mutations in the PANK2 gene in a Chinese patient with atypical pantothenate kinase-associated neurodegeneration.
Novel compound heterozygous mutations in the pantothenate kinase 2 gene in a korean patient with atypical pantothenate kinase associated neurodegeneration.
Novel compound heterozygous PANK2 gene mutations in a Chinese patient with atypical pantothenate kinase-associated neurodegeneration.
Novel gene mutations and clinical features in patients with pantothenate kinase-associated neurodegeneration.
Novel histopathologic findings in molecularly-confirmed pantothenate kinase-associated neurodegeneration.
Novel homozygous PANK2 mutation causing atypical pantothenate kinase-associated neurodegeneration (PKAN) in a Cypriot family.
Novel homozygous PANK2 mutation identified in a consanguineous Chinese pedigree with pantothenate kinase-associated neurodegeneration.
Novel mutation in the PANK2 gene leads to pantothenate kinase-associated neurodegeneration in a Pakistani family.
Novel PANK2 gene mutations in korean patient with pantothenate kinase-associated neurodegeneration presenting unilateral dystonic tremor.
Novel PANK2 gene mutations in two Chinese siblings with atypical pantothenate kinase-associated neurodegeneration.
Novel PANK2 mutation discovered among South East Asian children living in Thailand affected with pantothenate kinase associated neurodegeneration.
Novel PANK2 mutation in a Chinese boy with PANK2-associated neurodegeneration: A case report and review of Chinese cases.
Open-Label Fosmetpantotenate, a Phosphopantothenate Replacement Therapy in a Single Patient with Atypical PKAN.
Optic Atrophy in a Patient With Atypical Pantothenate Kinase-Associated Neurodegeneration.
Overexpression of Human Mutant PANK2 Proteins Affects Development and Motor Behavior of Zebrafish Embryos.
Pallidal neuronal apolipoprotein E in pantothenate kinase-associated neurodegeneration recapitulates ischemic injury to the globus pallidus.
Pallidal stimulation for dystonia in pantothenate kinase-associated neurodegeneration.
Pallidal stimulation for pantothenate kinase-associated neurodegeneration dystonia.
Pallidal stimulation improves pantothenate kinase-associated neurodegeneration.
Pallidal stimulation in atypical pantothenate kinase-associated neurodegeneration: six-year follow-up.
Pallidal stimulation in siblings with pantothenate kinase-associated neurodegeneration: Four-year follow-up.
PANK2 mutation screening recommended to confirm diagnosis of pantothenate kinase-associated neurodegeneration.
Pantethine rescues a Drosophila model for pantothenate kinase-associated neurodegeneration.
Pantethine treatment is effective in recovering the disease phenotype induced by ketogenic diet in a pantothenate kinase-associated neurodegeneration mouse model.
Pantothenate kinase-associated neurodegeneration (formerly Hallervorden-Spatz syndrome).
Pantothenate kinase-associated neurodegeneration (Hallervorden-Spatz syndrome).
Pantothenate kinase-associated neurodegeneration (PKAN) and PLA2G6-associated neurodegeneration (PLAN): review of two major neurodegeneration with brain iron accumulation (NBIA) phenotypes.
Pantothenate kinase-associated neurodegeneration (PKAN) in a child with Down syndrome. A case report and follow-up with MRI.
Pantothenate kinase-associated neurodegeneration (PKAN): molecular confirmation of a Turkish patient with a rare frameshift mutation in the coding region of the PANK2 gene.
Pantothenate kinase-associated neurodegeneration causing paradoxical vocal fold motion.
Pantothenate kinase-associated neurodegeneration in Korea: recurrent R440P mutation in PANK2 and outcome of deep brain stimulation.
Pantothenate kinase-associated neurodegeneration in two Chinese children: identification of a novel PANK2 gene mutation.
Pantothenate kinase-associated neurodegeneration in two Taiwanese siblings: identification of a novel PANK2 gene mutation.
Pantothenate kinase-associated neurodegeneration initially presenting as postural tremor alone in a Japanese family with homozygous N245S substitutions in the pantothenate kinase gene.
Pantothenate kinase-associated neurodegeneration is not a synucleinopathy.
Pantothenate kinase-associated neurodegeneration mimicking Tourette syndrome: a case report and review of the literature.
Pantothenate kinase-associated neurodegeneration with increased lentiform nuclei cerebral blood flow.
Pantothenate kinase-associated neurodegeneration.
Pantothenate kinase-associated neurodegeneration: altered mitochondria membrane potential and defective respiration in Pank2 knock-out mouse model.
Pantothenate kinase-associated neurodegeneration: Clinical aspects, diagnosis and treatments.
Pantothenate kinase-associated neurodegeneration: Clinical description of 10 patients and identification of new mutations.
Pantothenate kinase-associated neurodegeneration: insights from a Drosophila model.
Pantothenate kinase-associated neurodegeneration: MR imaging, proton MR spectroscopy, and diffusion MR imaging findings.
Pantothenate kinase-associated neurodegeneration: novel mutations in the PANK2 gene in an Argentinean young woman.
Pantothenate Rescues Iron Accumulation in Pantothenate Kinase-Associated Neurodegeneration Depending on the Type of Mutation.
Parkinson's Disease and Metal Storage Disorders: A Systematic Review.
Partial deficit of pantothenate kinase 2 catalytic activity in a case of tremor-predominant neurodegeneration with brain iron accumulation.
Pathophysiology and treatment of neurodegeneration with brain iron accumulation in the pediatric population.
Phenotypes and genotypes of patients with pantothenate kinase-associated neurodegeneration in Asian and Caucasian populations: 2 cases and literature review.
Pilot trial on the efficacy and safety of pantethine in children with pantothenate kinase-associated neurodegeneration: a single-arm, open-label study.
Potential Treatment of Retinal Diseases with Iron Chelators.
Precision medicine in pantothenate kinase-associated neurodegeneration.
Progressive dystonia in a 12-year-old boy.
Psychiatric symptoms in an adolescent reveal a novel compound heterozygous mutation of the PANK2 gene in the atypical PKAN syndrome.
Rational Design of Novel Therapies for Pantothenate Kinase-Associated Neurodegeneration.
Retinal iron homeostasis in health and disease.
Retinitis pigmentosa in pantothenate kinase-associated neurodegeneration.
Role of iron in neurodegenerative disorders.
Safety and efficacy of deferiprone for pantothenate kinase-associated neurodegeneration: a randomised, double-blind, controlled trial and an open-label extension study.
Sensory Tricks in Pantothenate Kinase-Associated Neurodegeneration: Video-Analysis of 43 Patients.
Sequence Variations in Mitochondrial Ferritin: Distribution in Healthy Controls and Different Types of Patients.
Severe tongue protrusion dystonia: clinical syndromes and possible treatment.
Siblings with the adult-onset slowly progressive type of pantothenate kinase-associated neurodegeneration and a novel mutation, Ile346Ser, in PANK2: clinical features and (99m)Tc-ECD brain perfusion SPECT findings.
Skin fibroblasts from pantothenate kinase-associated neurodegeneration patients show altered cellular oxidative status and have defective iron-handling properties.
Sleep in genetically confirmed pantothenate kinase-associated neurodegeneration: a video-polysomnographic study.
Status dystonicus in pantothenate kinase-associated neurodegeneration due to internal pulse generator depletion: Case study and literature review.
Subthalamic Nuclei Stimulation in Patients With Pantothenate Kinase-Associated Neurodegeneration (PKAN).
Surgery for other movement disorders: dystonia, tics.
Susceptibility-weighted imaging in pantothenate kinase-associated neurodegeneration.
Syndromes of neurodegeneration with brain iron accumulation.
T2* and FSE MRI distinguishes four subtypes of neurodegeneration with brain iron accumulation.
The "Eye-of-the-Tiger" Sign may be Absent in the Early Stages of Classic Pantothenate Kinase Associated Neurodegeneration.
The Case of a Patient with Pantothenate Kinase-Associated Neurodegeneration Presenting with a Prolonged History of Stuttering Speech and a Misdiagnosis of Parkinson's Disease.
The diverse phenotype and genotype of pantothenate kinase-associated neurodegeneration.
The eye-of-the-tiger sign is not a reliable disease marker for Hallervorden-Spatz syndrome.
The FOsmetpantotenate Replacement Therapy (FORT) randomized, double-blind, Placebo-controlled pivotal trial: Study design and development methodology of a novel primary efficacy outcome in patients with pantothenate kinase-associated neurodegeneration.
The History of Deferiprone (L1) and the Paradigm of the Complete Treatment of Iron Overload in Thalassaemia.
The neuropsychiatry of neuroacanthocytosis syndromes.
The synthesis of minds and molecules leads to potential therapy for pantothenate kinase-associated neurodegeneration.
Tongue Protrusion Dystonia in Pantothenate Kinase-Associated Neurodegeneration.
Transcranial sonography in pantothenate kinase-associated neurodegeneration.
Treatment of Classic Pantothenate Kinase-Associated Neurodegeneration with Deferiprone and Intrathecal Baclofen.
Treatment Responsiveness of Parkinsonism in Atypical Pantothenate Kinase-Associated Neurodegeneration.
Tremor-Dominant Pantothenate Kinase-associated Neurodegeneration.
Turnover rate of coenzyme A in mouse brain and liver.
Unraveling the Hallervorden-Spatz syndrome: pantothenate kinase-associated neurodegeneration is the name.
Untangling the Thorns: Advances in the Neuroacanthocytosis Syndromes.
Update on neurodegeneration with brain iron accumulation.
[Anesthesia in patients with NBIA : Neurodegeneration with brain iron accumulation].
[From the Hallervorden-Spatz eponym to the molecular terminology].
[Mandibular fracture in a patient with pantothenate kinase-associated neurodegeneration (Hallervorden-Spatz syndrome)].
[Neuroacanthocytosis update]
[Pedigree analysis of C19ORF12 p.Asp18Tyr mutation in a family with mitochondrial membrane protein associated neurodegeneration].
[Phenotypic and genotypic features of twenty children with classic pantothenate kinase-associated neurodegeneration].
[«A most strange instance of illness in several siblings» - first description of a rare neurological disease in 1830?].
Papilloma
(2'-5')oligo(A) synthetase as a monitor of interferon action in juvenile laryngeal papillomatosis.
Paralysis
A patient with pantothenate kinase-associated neurodegeneration and supranuclear gaze palsy.
Neuropareidolia: diagnostic clues apropos of visual illusions.
Neuropathology and pathogenesis of extrapyramidal movement disorders: a critical update-I. Hypokinetic-rigid movement disorders.
Structural studies on the inactivation of gamma-glutamylcysteine synthetase by the disulphide analogues of radioprotective cysteamine derivatives. Effects of aminoalkyl and hydroxyalkyl chain length and beta beta-bis-dimethylation.
Paraneoplastic Syndromes
Anti-EJ Antibody-positive Anti-synthetase Syndrome Associated with Retroperitoneal Sarcoma.
Parkinson Disease
A Scale to Assess Activities of Daily Living in Pantothenate Kinase-Associated Neurodegeneration.
Botulinum toxin in the treatment of sialorrhea.
Identification of far upstream element-binding protein-1 as an authentic Parkin substrate.
Iron chelation in the treatment of neurodegenerative diseases.
Mutations in the pantothenate kinase gene PANK2 are not associated with Parkinson disease.
New Perspectives in Iron Chelation Therapy for the Treatment of Neurodegenerative Diseases.
Role of iron in neurodegenerative disorders.
Sequence Variations in Mitochondrial Ferritin: Distribution in Healthy Controls and Different Types of Patients.
The Case of a Patient with Pantothenate Kinase-Associated Neurodegeneration Presenting with a Prolonged History of Stuttering Speech and a Misdiagnosis of Parkinson's Disease.
Parkinsonian Disorders
4'-Phosphopantetheine corrects CoA, iron, and dopamine metabolic defects in mammalian models of PKAN.
A patient with pantothenate kinase-associated neurodegeneration and supranuclear gaze palsy.
A pilot trial of deferiprone for neurodegeneration with brain iron accumulation.
Mutations in the pantothenate kinase gene PANK2 are not associated with Parkinson disease.
Parkinson's Disease and Metal Storage Disorders: A Systematic Review.
Treatment Responsiveness of Parkinsonism in Atypical Pantothenate Kinase-Associated Neurodegeneration.
Perinatal Death
DNA constructs designed to produce short hairpin, interfering RNAs in transgenic mice sometimes show early lethality and an interferon response.
Neonatal death due to carbamyl phosphate synthetase deficiency.
Periodontal Diseases
Biochemical alterations in inflammatory periodontal diseases I. Poly (ADP-ribose) synthetase activity in gingiva and gingival fibroblasts from humans with periodontitis.
Periodontitis
Biochemical alterations in inflammatory periodontal diseases I. Poly (ADP-ribose) synthetase activity in gingiva and gingival fibroblasts from humans with periodontitis.
MxA expression induced by ?-defensin in healthy human periodontal tissue.
Peripheral Nerve Injuries
Koumine enhances spinal cord 3?-hydroxysteroid oxidoreductase expression and activity in a rat model of neuropathic pain.
Peripheral Nervous System Diseases
Alternative stable conformation capable of protein misinteraction links tRNA synthetase to peripheral neuropathy.
Clinical, neurophysiological and morphological study of dominant intermediate Charcot-Marie-Tooth type C neuropathy.
Disorders of phospholipids, sphingolipids and fatty acids biosynthesis: toward a new category of inherited metabolic diseases.
Drosophila as a platform to predict the pathogenicity of novel aminoacyl-tRNA synthetase mutations in CMT.
tRNA overexpression rescues peripheral neuropathy caused by mutations in tRNA synthetase.
Peritonitis
Changes of hepatic sinusoids in experimental septicemia of rats are correlated with the production of nitrogen monoxide. A morphometrical and immunohistochemical study.
Protective effect of poly(ADP-ribose) synthetase inhibition on multiple organ failure after zymosan-induced peritonitis in the rat.
Persistent Infection
Altered tissue distribution of viral replication and T cell spreading is pivotal in the protection against fatal lymphocytic choriomeningitis in mice after neutralization of IFN-alpha/beta.
Role of interferon in persistent infection of macrophages with herpes simplex virus.
Suppression of interferon-induced oligo-2',5'-adenylate synthetase induction in persistent infection.
Phenylketonurias
Atypical phenylketonuria caused by 7, 8-dihydrobiopterin synthetase deficiency.
Atypical phenylketonuria due to dihydrobiopterin synthetase deficiency.
Central tegmental tract involvement in an infant with 6-pyruvoyltetrahydropterin synthetase deficiency.
Differential diagnosis of tetrahydrobiopterin deficiency.
Effect of phenylpyruvate on enzymes involved in fatty acid synthesis in rat brain.
Excretion of pterins in phenylketonuria and phenylketonuria variants.
Neonatal hyperphenylalaninaemia presumably caused by a new variant of biopterin synthetase deficiency.
Pterin metabolism in normal subjects and hyperphenylalaninaemic patients.
[Atypical form of phenylketonuria caused by lack of dihydrobiopterin synthetase activity]
[Malignant phenylketonuria caused by biopterin synthetase deficiency. Study of neuromediator catabolites in the cerebrospinal fluid during treatment]
[Trial of indirect screening of tetrahydrobiopterin deficiency]
Pheochromocytoma
Decrease in the level of poly(ADP-ribose) synthetase during nerve growth factor-promoted neurite outgrowth in rat pheochromocytoma PC12 cells.
Nerve growth factor induces changes in (2'-5')oligo(A) synthetase and 2'-phosphodiesterase activities during differentiation of PC12 pheochromocytoma cells.
[Evaluation of urinary excretion of free-cortisol in patients with abnormal pituitary-adrenal axes]
phospholipase a2 deficiency
Disorders of phospholipids, sphingolipids and fatty acids biosynthesis: toward a new category of inherited metabolic diseases.
Pick Disease of the Brain
Neuropathology and pathogenesis of extrapyramidal movement disorders: a critical update-I. Hypokinetic-rigid movement disorders.
Picornaviridae Infections
Constitutive expression of (2'-5') oligo A synthetase confers resistance to picornavirus infection.
Pityriasis Rosea
[Serum interferon level and (2'-5')-oligo(A) synthetase activity in pityriasis rosea, basalioma, melanoma and molluscum contagiosum]
Plague
The Yersinia pestis siderophore, yersiniabactin, and the ZnuABC system both contribute to zinc acquisition and the development of lethal septicaemic plague in mice.
Plasmacytoma
Deoxyribonucleic acid synthesis. I. Effect of in vivo cyclophosphamide treatment on the in vitro activity of the deoxyribonucleic acid synthetase system of sensitive and resistant plasmacytomas.
Pharmaceutical inhibition of glycogen synthetase kinase-3? reduces multiple myeloma-induced bone disease in a novel murine plasmacytoma xenograft model.
Pleurisy
Peroxynitrite-mediated DNA strand breakage activates poly (ADP-ribose) synthetase and causes cellular energy depletion in carrageenan-induced pleurisy.
Regulation of prostaglandin production by inhibition of poly (ADP-ribose) synthase in carrageenan-induced pleurisy.
Role of peroxynitrite and poly (ADP-ribose) synthetase on cellular energy depletion in carrageenan-induced pleurisy.
Pneumonia
Clinical characteristics of interstitial lung diseases positive to different anti-synthetase antibodies.
Clinical significance of radiological patterns of HRCT and their association with macrophage activation in dermatomyositis.
Inflammatory myopathy, bronchiolitis obliterans/organizing pneumonia, and anti-Jo-1 antibodies--an interesting association.
Structural characterization of a new N-substituted pantothenamide bound to pantothenate kinases from Klebsiella pneumonia and Staphylococcus aureus.
Polycystic Ovary Syndrome
Polymorphism of glycogen synthetase gene in polycystic ovary syndrome.
[Association study between a polymorphism of aldosterone synthetase gene and the pathogenesis of polycystic ovary syndrome]
Polymyositis
A case of anti-aminoacyl tRNA synthetase (ARS) antibody-positive polymyositis (PM)/dermatomyositis (DM)-associated interstitial pneumonia (IP) successfully controlled with bosentan therapy.
A case of polymyositis with anti-histidyl-t-RNA synthetase (Jo-1) antibody syndrome following extensive vinyl chloride exposure.
Acute respiratory distress syndrome secondary to antisynthetase syndrome is reversible with tacrolimus.
Clinical significance and new detection system of autoantibodies in myositis with interstitial lung disease.
Correlation of Antisynthetase Antibody Levels with Disease Course in a Patient with Interstitial Lung Disease and Elevated Muscle Enzymes.
Genome-wide association study identifies HLA 8.1 ancestral haplotype alleles as major genetic risk factors for myositis phenotypes.
Glycyl-tRNA synthetase.
HLA-DRB1*0101/*0405 is associated with susceptibility to Anti-MDA5 antibody-positive dermatomyositis in the Japanese population.
Juvenile polymyositis associated with anti-OJ (anti-isoleucyl-tRNA synthetase) autoantibody in a 13-year-old girl.
Nivolumab-induced anti-aminoacyl-tRNA synthetase antibody-positive polymyositis complicated by interstitial pneumonia in a patient with lung adenocarcinoma.
Polymyositis, pulmonary fibrosis and autoantibodies to aminoacyl-tRNA synthetase enzymes.
Reliability and clinical utility of Enzyme-linked immunosorbent assay for detection of anti-aminoacyl-tRNA synthetase antibody.
Rituximab in refractory idiopathic inflammatory myopathies and antisynthetase syndrome: personal experience and review of the literature.
Wide cross-species aminoacyl-tRNA synthetase replacement in vivo: yeast cytoplasmic alanine enzyme replaced by human polymyositis serum antigen.
Porcine Reproductive and Respiratory Syndrome
Nucleic Acid Immunity and DNA Damage Response: New Friends and Old Foes.
Porcine 2', 5'-oligoadenylate synthetase 2 inhibits porcine reproductive and respiratory syndrome virus replication in vitro.
Porphyria Cutanea Tarda
Hepatic -aminolaevulinic acid synthetase activity in porphyria cutanea tarda.
Red blood cell rhodanese: its possible role in modulating delta-aminolaevulinate synthetase activity in mammals.
Porphyria, Acute Intermittent
Effect of lead on hepatic delta-aminolaevulinic acid synthetase activity in the rat: a model for drug sensitivity in intermittent acute porphyria.
R173W Mutation of Hydroxymethylbilane Synthetase Is Associated With Acute Intermittent Porphyria Complicated With Rhabdomyolysis: The First Report.
Red blood cell rhodanese: its possible role in modulating delta-aminolaevulinate synthetase activity in mammals.
Porphyria, Erythropoietic
-aminolevulinic acid synthetase activity in human plasma: relation to erythropoiesis and evidence of induction in erythropoietic porphyria.
Congenital erythropoietic porphyria in two siblings.
Congenital erythropoietic porphyria: dilemmas in present day management.
Correction of congenital erythropoietic porphyria by bone marrow transplantation.
Porphyria, Variegate
Red blood cell rhodanese: its possible role in modulating delta-aminolaevulinate synthetase activity in mammals.
Porphyrias
Effect of ethanol on liver delta-aminolaevulinate synthetase activity and urinary porphyrin excretion in symptomatic porphyria.
Hepatic -aminolaevulinic acid synthetase activity in porphyria cutanea tarda.
Hepatic delta-aminolaevulinic acid synthetase activity in symptomatic porphyria.
Increased hepatic delta-aminolaevulinic acid synthetase in ethionine-induced porphyria in the rat.
R173W Mutation of Hydroxymethylbilane Synthetase Is Associated With Acute Intermittent Porphyria Complicated With Rhabdomyolysis: The First Report.
Red blood cell rhodanese: its possible role in modulating delta-aminolaevulinate synthetase activity in mammals.
The influence of actinomycin D on the activity of delta-aminolaevulinic acid synthetase and dehydratase in the liver of mice and rats treated by griseofulvin.
[Determination of uroporphyrinogen 1 synthetase in porphyria]
Porphyrias, Hepatic
Polychlorinated biphenyls as inducers of hepatic porphyria in Japanese quail, with special reference to -aminolevulinic acid synthetase activity, fluorescence, and residues in the liver.
Pre-Eclampsia
Assessment of ADMA, estradiol, and progesterone in severe preeclampsia.
Trial of prophylactic administration of TXA2 synthetase inhibitor, ozagrel hydrochloride, for preeclampsia.
[Mast cells as a source of nitric oxide in the human placenta--morphometric analysis in preeclampsia complicated pregnancy]
Precursor Cell Lymphoblastic Leukemia-Lymphoma
[Study of the correlation between the expression level of asparagine synthetase and the outcome of children with acute lymphocytic leukemia]
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
Cytidine triphosphate (CTP) synthetase activity during cell cycle progression in normal and malignant T-lymphocytic cells.
[Asparagine synthetase activity in pediatric acute lymphoblastic leukemia]
Pregnancy Complications
A novel mouse model for genetic variation in 10-formyltetrahydrofolate synthetase exhibits disturbed purine synthesis with impacts on pregnancy and embryonic development.
Low Dietary Folate Interacts with MTHFD1 Synthetase Deficiency in Mice, a Model for the R653Q Variant, to Increase Incidence of Developmental Delays and Defects.
Primary Ovarian Insufficiency
Acyl-CoA synthetase long-chain family member 6 is associated with premature ovarian failure.
Prion Diseases
Copper, Iron, and Manganese Toxicity in Neuropsychiatric Conditions.
Proctocolitis
Mucosal glucosamine synthetase activity in inflammatory bowel disease.
Progeria
Phenylalanyl synthetase function in cultured fibroblasts from subjects with progeria.
Propionic Acidemia
Carglumic acid: an additional therapy in the treatment of organic acidurias with hyperammonemia?
Pilot use of the early motor repertoire in infants with inborn errors of metabolism: Outcomes in early and middle childhood.
Prostatic Neoplasms
Effects of platelet-activating factor and its differential regulation by androgens and steroid hormones in prostate cancers.
RNase L and the NLRP3-inflammasome: An old merchant in a new trade.
Proteinuria
A role for thromboxane in complement-mediated glomerular injury.
Increased glomerular thromboxane synthesis as a possible cause of proteinuria in experimental nephrosis.
Involvement of thromboxane A2, leukotrienes and free radicals in puromycin nephrosis in rats.
Protoporphyria, Erythropoietic
-Aminolevulinic acid synthetase activity in erythroblasts of patients with erythropoietic protoporphyria.
Decreased haem synthetase activity in blood cells of patients with erythropoietic protoporphyria.
Hepatic and erythropoietic protoporphyria. Delta-aminolevulinic acid synthetase, fluorescence, and microfluorospectrophotometric study.
Induction of hepatic aminolevulinate acid synthetase activity by isoflurane in a genetic model for erythropoietic protoporphyria.
Red blood cell rhodanese: its possible role in modulating delta-aminolaevulinate synthetase activity in mammals.
Pseudorabies
Autonomous Parvoviruses neither Stimulate nor Are Inhibited by the Type I Interferon Response in Human Normal or Cancer Cells.
Psoriasis
Cytokine milieu of atopic dermatitis, as compared to psoriasis, skin prevents induction of innate immune response genes.
Epigenetic regulation of OAS2 shows disease-specific DNA methylation profiles at individual CpG sites.
Pterygium
Expression of vascular endothelial growth factor and inducible nitric oxide synthase in pterygia.
Pulmonary Alveolar Proteinosis
Deep phenotyping of MARS1 (interstitial lung and liver disease) and LARS1 (infantile liver failure syndrome 1) recessive multisystemic disease using Human Phenotype Ontology annotation: Overlap and differences. Case report and review of literature.
Methionine supplementation for multi-organ dysfunction in MetRS-related pulmonary alveolar proteinosis.
Pulmonary Embolism
Differential expression of 5-HT-related genes in symptomatic pulmonary embolism patients.
Pulmonary Fibrosis
Dermatomyositis and pulmonary fibrosis associated with anti-Jo-1 antibody.
Polymyositis, pulmonary fibrosis and autoantibodies to aminoacyl-tRNA synthetase enzymes.
[Pulmonary fibrosis as a presentation form of the Jo-1 syndrome]
purine-nucleoside phosphorylase deficiency
Altered erythrocyte nucleotide patterns are characteristic of inherited disorders of purine or pyrimidine metabolism.
pyruvate kinase deficiency
Heme synthesis in hereditary hemolytic anemias: decreased delta-aminolevulinic acid synthetase in hemoglobin Köln disease.
Rabies
Distribution of rabies virus, interferon and interferon-mediated enzymes in the brains of virus-infected rats.
Radiculopathy
Roles of thromboxane A2 and leukotriene B4 in radicular pain induced by herniated nucleus pulposus.
Raynaud Disease
[Antisynthetase syndromes].
Rectal Neoplasms
A phase II study of preoperative chemoradiation with tegafur-uracil plus leucovorin for locally advanced rectal cancer with pharmacogenetic analysis.
Reoviridae Infections
Reovirus type 3 synthesizes proteins in interferon-treated HeLa cells without reversing the antiviral state.
Reperfusion Injury
Comparison of the thromboxane synthetase inhibitor dazoxiben and the prostacyclin mimetic iloprost in an animal model of acute ischaemia and reperfusion.
Development of novel, water-soluble inhibitors of poly (adenosine 5'-diphosphate ribose) synthetase activity for use in shock and ischemia-reperfusion injury.
Effect of genetic disruption of poly (ADP-ribose) synthetase on delayed production of inflammatory mediators and delayed necrosis during myocardial ischemia-reperfusion injury.
Inhibition of the activity of poly(ADP ribose) synthetase reduces ischemia-reperfusion injury in the heart and skeletal muscle.
Inhibitors of poly (ADP-ribose) synthetase reduce renal ischemia-reperfusion injury in the anesthetized rat in vivo.
Intratracheal poly (ADP) ribose synthetase inhibition ameliorates lung ischemia reperfusion injury.
Molecular mechanism underlying Akt activation in zinc-induced cardioprotection.
Myocardial ischemic preconditioning in rodents is dependent on poly (ADP-ribose) synthetase.
Myocardial protection by PJ34, a novel potent poly (ADP-ribose) synthetase inhibitor.
Poly (ADP) ribose synthetase inhibition in alveolar macrophages undergoing hypoxia and reoxygenation.
Poly(adenosine diphosphate-ribose) synthetase inhibitor 3-aminobenzamide alleviates cochlear dysfunction induced by transient ischemia.
Prevention of myocardial reperfusion injury by poly(ADP-ribose) synthetase inhibitor, 3-aminobenzamide, in cardioplegic solution: in vitro study of isolated rat heart model.
Protection against myocardial ischemia and reperfusion injury by 3-aminobenzamide, an inhibitor of poly (ADP-ribose) synthetase.
Role of peroxynitrite and neuronal nitric oxide synthase in the activation of poly(ADP-ribose) synthetase in a murine model of cerebral ischemia-reperfusion.
Role of poly (ADP) ribose synthetase in lung ischemia-reperfusion injury.
Respiratory Insufficiency
Diagnostic utility of transbronchial lung cryobiopsy: Two cases of anti-aminoacyl-tRNA synthetase syndrome with respiratory failure.
[Interstitial lung disease in patients with connective tissue diseases]
Restless Legs Syndrome
Sequence Variations in Mitochondrial Ferritin: Distribution in Healthy Controls and Different Types of Patients.
Retinal Degeneration
Metabolic consequences of mitochondrial coenzyme A deficiency in patients with PANK2 mutations.
Neuro-ophthalmologic and electroretinographic findings in pantothenate kinase-associated neurodegeneration (formerly Hallervorden-Spatz syndrome).
Pantethine treatment is effective in recovering the disease phenotype induced by ketogenic diet in a pantothenate kinase-associated neurodegeneration mouse model.
Potential Treatment of Retinal Diseases with Iron Chelators.
Retinal iron homeostasis in health and disease.
Retinal Detachment
Distribution of p27(KIP1), cyclin D1, and proliferating cell nuclear antigen after retinal detachment.
Retinitis Pigmentosa
Characterization of the human PANK2 promoter.
HARP syndrome is allelic with pantothenate kinase-associated neurodegeneration.
Potential Treatment of Retinal Diseases with Iron Chelators.
Retinitis pigmentosa in pantothenate kinase-associated neurodegeneration.
Rett Syndrome
Genomic structure of a human holocytochrome c-type synthetase gene in Xp22.3 and mutation analysis in patients with Rett syndrome.
Reye Syndrome
Abnormalities of carbamyl phosphate synthetase and ornithine transcarbamylase in liver of patients with Reye's syndrome.
Letter: Carbamyl phosphate synthetase and ornithine transcarbamylase in liver of Reye's syndrome.
Partial carbamyl phosphate synthetase deficiency, simulating Reye's syndrome, in a 9-year-old girl.
Partial N-acetyl-glutamate synthetase deficiency masquerading as a valproic acid-induced Reye-like syndrome.
Reye's syndrome simulacra in liver of mice after treatment with chemical agents and encephalomyocarditis virus.
Transiently reduced activity of carbamyl phosphate synthetase and ornithine transcarbamylase in liver of children with Reye's syndrome.
Rhabdomyolysis
R173W Mutation of Hydroxymethylbilane Synthetase Is Associated With Acute Intermittent Porphyria Complicated With Rhabdomyolysis: The First Report.
Rheumatic Heart Disease
[Changes in the end part of the ECG ventricular complex under the effect of digitalis preparations and their combination with metabolic preparations]
Rhinitis
The effect of calcium pantothenate on induced whealing and on seasonal rhinitis.
Rickets
Relationship between polymorphisms in vitamin D metabolism-related genes and the risk of rickets in Han Chinese children.
Sarcoidosis
Neuropareidolia: diagnostic clues apropos of visual illusions.
Oligo-2',5'-adenylate synthetase activity in peripheral blood mononuclear leukocytes in various diseases.
[Investigations of interferon and oligo-2',5'-adenylate systems in endogenous uveitis]
Sarcoidosis, Pulmonary
Oligo-2',5'-adenylate synthetase in pulmonary sarcoidosis and idiopathic pulmonary fibrosis.
Sarcoma
Carbamoyl phosphate synthetase (glutamine-hydrolyzing): increased activity in cancer cells.
Enhanced activity of tRNA-pseudouridine synthetase in Yoshida ascites sarcoma.
Infection with Moloney murine sarcoma virus inhibits myogenesis and alters the myogenic-associated (2'-5')oligoadenylate synthetase expression and activity.
Regulatory properties and behavior of activity of carbamoyl phosphate synthetase II (glutamine-hydrolyzing) in normal and proliferating tissues.
Reversibility of the antiproliferative effect of interferon.
Sheep gene mapping: additional DNA markers included (CASB, CASK, LALBA, IGF-1 and AMH).
Specific antigrowth effect of interferon on mouse cells transformed by murine sarcoma virus.
Sarcoma 180
Effects of the chiral isomers of erythro- and threo-9-(2-hydroxy-3-nonyl)adenine on purine metabolism in sarcoma 180 cells.
Sarcoma, Avian
Studies of carcinogenesis by avian sarcoma viruses. II. Virus-induced increase in hyaluronic acid synthetase in chicken fibroblasts.
Sarcoma, Kaposi
Hormonal and immunological regulation of 2', 5'-oligoadenylate synthetase activity in human peripheral blood mononuclear cells.
Sarcoma, Myeloid
Identification of a third form of glycogen synthetase in rat chloroma tumors.
Scleroderma, Systemic
Anti-synthetase syndrome positive for anti-isoleucyl-tRNA synthetase antibodies: an unusual case overlapping with systemic sclerosis and Sjogren's syndrome.
Increased expression of 2'5'oligoadenylate synthetase and double-stranded RNA dependent protein kinase messenger RNAs on affected skin of systemic sclerosis patients.
[Association of anti synthetase syndrome and limited systemic sclerosis in a patient: successful treatment with rituximab].
Scoliosis
Neuropareidolia: diagnostic clues apropos of visual illusions.
Scrapie
Identification of upregulated genes in scrapie-infected brain tissue.
Seizures
Expansion of the QARS deficiency phenotype with report of a family with isolated supratentorial brain abnormalities.
Methionine sulfoximine seizures. 8. The dissociation of the convulsant and glutamine synthetase inhibitory effects.
Neuroendocrine involvements of the prostaglandin autacoids.
Prospective cohort study for identification of underlying genetic causes in neonatal encephalopathy using whole-exome sequencing.
[Hepatic glycogen synthetase deficiency or glycogen storage disease-zero. Mild phenotype with partial enzymatic defect]
[Metabolic studies on epileptic seizures. The activity of glutaminase and glutamine synthetase and ammonia metabolism before and during cerebral convulsions]
Seizures, Febrile
Systematic review of the role of prostaglandins and their synthetase inhibitors with respect to febrile seizures.
Sepsis
Changes of hepatic sinusoids in experimental septicemia of rats are correlated with the production of nitrogen monoxide. A morphometrical and immunohistochemical study.
Does the activation of poly (ADP-ribose) synthetase mediate tissue injury in the sepsis induced by cecal ligation and puncture?
Does the activation of poly (ADP-ribose) synthetase mediate tissue injury in the sepsis induced by cecal ligation and puncture? Shock 16:137-142, 2001.
Poly (ADP-ribose) synthetase inhibitor has a heart protective effect in a rat model of experimental sepsis.
Protective effect of a novel, potent inhibitor of poly(adenosine 5'-diphosphate-ribose) synthetase in a porcine model of severe bacterial sepsis.
Regulation of rat liver S-adenosylmethionine synthetase during septic shock: role of nitric oxide.
The potential role of thromboxane and prostacyclin in endotoxic and septic shock.
Thromboxane synthetase inhibition and thromboxane receptor blockade preserve pulmonary and circulatory function in a porcine burn sepsis model.
Shock, Septic
Poly (ADP-ribose) synthetase activation mediates pulmonary microvascular and intestinal mucosal dysfunction in endotoxin shock.
Protective effect of Y-20811, a long-lasting thromboxane synthetase inhibitor, on endotoxin shock in rabbits.
Sialorrhea
Botulinum toxin in the treatment of sialorrhea.
Silicosis
The Ameliorative Effects of Arctiin and Arctigenin on the Oxidative Injury of Lung Induced by Silica via TLR-4/NLRP3/TGF-? Signaling Pathway.
Sjogren's Syndrome
Anti-synthetase syndrome positive for anti-isoleucyl-tRNA synthetase antibodies: an unusual case overlapping with systemic sclerosis and Sjogren's syndrome.
Skin Diseases
[Results in the use of calcium pantothenate cream in the treatment of various skin diseases in children]
[Serum interferon level and (2'-5')-oligo(A) synthetase activity in pityriasis rosea, basalioma, melanoma and molluscum contagiosum]
[The therapeutic action of an ointment with a base of hydrocortisone, lactic acid and calcium pantothenate (Lactacyd hydrocortisone) in various dermatoses.]
Small Cell Lung Carcinoma
Overcoming Radiation Resistance by Iron-Platinum Metal Alloy Nanoparticles in Human Copper Transport 1-Overexpressing Cancer Cells via Mitochondrial Disturbance.
Soft Tissue Infections
The clinical trial of streptomycin pantothenate in the treatment of soft tissue infections.
Spinal Cord Compression
Preventive effects of lecithinized superoxide dismutase and methylprednisolone on spinal cord injury in rats: transcriptional regulation of inflammatory and neurotrophic genes.
Spinal Cord Injuries
Peroxynitrite production and activation of poly (adenosine diphosphate-ribose) synthetase in spinal cord injury.
[Beneficial effect of a selective TXA2 synthetase inhibitor, OKY-046, both on thromboxane B2 production and vascular damage after spinal cord injury in rat spinal cord]
Starvation
Aminoacyl-tRNA synthetase gene regulation in Bacillus subtilis: induction, repression and growth-rate regulation.
As (and when) you like it: on-demand phospholipid synthesis drives phagophore expansion during autophagy.
Ca(2+)-regulated cyclic electron flow supplies ATP for nitrogen starvation-induced lipid biosynthesis in green alga.
Characterization of eukaryotic-like kinase activity in Escherichia coli using the gene-protein database.
Decreased phosphoribosylpyrophosphate as the basis for decreased purine synthesis during amino acid starvation of human lymphoblasts.
Dynamics of liver glycogen: the topochemistry of glycogen synthesis, glycogen content and glycogenolysis under the experimental conditions of glycogen accumulation and depletion.
Effect of extreme amino acid starvation on the protein synthetic machinery of CHO cells.
Effect of starvation and insulin-induced hypoglycemia on oxidative stress scavenger system and electron transport chain complexes from rat brain, liver, and kidney.
Effect of starvation on the N-acetylglutamate system of rat liver.
Effect of starvation on tRNA synthesis, amino acid pool, tRNA charging levels and aminoacyl-tRNA synthetase activities in the posterior silk gland of Bombyx mori L.
Effect of supplemental dietary chromium or nicotinic acid on carbohydrate metabolism during basal, starvation, and refeeding periods in poults.
Escherichia coli RelA Regulation via Its C-Terminal Domain.
Factors influencing the development of urea-synthesizing enzymes in rat liver.
Induction of heritable respiratory deficiency in Saccharomyces by pantothenate starvation.
Inhibition of tRNA Synthetases Induces Persistence in Chlamydia.
Mammalian cells do not have a stringent response.
Mutational analysis of the Escherichia coli spoT gene identifies distinct but overlapping regions involved in ppGpp synthesis and degradation.
Penicillin binding protein 2 is dispensable in Escherichia coli when ppGpp synthesis is induced.
Phosphoribosylpyrophosphate synthetase of Escherichia coli, Identification of a mutant enzyme.
Purine synthesis during amino acid starvation of lymphoblasts with HPRT deficiency or PP-ribose-P synthetase overactivity decreases less than in normal cells.
Rapid Curtailing of the Stringent Response by Toxin-Antitoxin Module-Encoded mRNases.
Regulation of aromatic amino acid biosynthesis in Escherichia coli K-12: control of the aroF-tyrA operon in the absence of repression control.
Regulation of beta-Glucan Synthetase Activity by Auxin in Pea Stem Tissue: I. Kinetic Aspects.
Regulation of hepatic fatty acid synthetase in the obese-hyperglycemic mutant mouse.
Regulation of the synthesis of unsaturated fatty acids by growth temperature in Bacillus subtilis.
relA-Independent amino acid starvation response network of Streptococcus pyogenes.
SOLUBILIZATION OF MOUSE LIVER GLYCOGEN SYNTHETASE AND PHOSPHORYLASE DURING STARVATION GLYCOGENOLYSIS AND ITS REVERSAL BY CORTISOL.
Starvation causes female-to-male sex reversal through lipid metabolism in the teleost fish, medaka (Olyzias latipes).
Sterilization by Adaptive Immunity of a Conditionally Persistent Mutant of Mycobacterium tuberculosis.
Stringent response governs the oxidative stress resistance and virulence of Francisella tularensis.
Temperature-sensitive growth and decreased thermotolerance associated with relA mutations in Escherichia coli.
The ECF sigma factor SigT regulates actinorhodin production in response to nitrogen stress in Streptomyces coelicolor.
The effects of experimental inflammation on turnover of fatty acid synthetase and levels of fatty acid synthetase messenger RNA in rat liver.
The histidyl-tRNA synthetase-related sequence in the eIF-2 alpha protein kinase GCN2 interacts with tRNA and is required for activation in response to starvation for different amino acids.
The molecular aetiology of tRNA synthetase depletion: induction of a GCN4 amino acid starvation response despite homeostatic maintenance of charged tRNA levels.
The ppGpp synthetase gene (relA) of Streptomyces coelicolor A3(2) plays a conditional role in antibiotic production and morphological differentiation.
The role of strigolactones in P deficiency induced transcriptional changes in tomato roots.
Uncoupling of bacterial growth by pantothenate starvation.
Stevens-Johnson Syndrome
Soluble FAS ligand: a discriminating feature between drug-induced skin eruptions and viral exanthemas.
Stomach Neoplasms
Pyrimidine nucleotide synthesis is more extensive in poorly differentiated than in well-differentiated human gastric carcinoma.
YARS as an oncogenic protein that promotes gastric cancer progression through activating PI3K-Akt signaling.
Stomach Ulcer
[Effect of 5-[2-(diethylamino)ethyl]amino-5,11- dihydro[1]benzoxepino[3,4-b]pyridine trihydrochloride (KW-5805) on the biosynthesis of rat gastric mucus]
Stroke
Low intakes of carotene, vitamin?B2 , pantothenate and calcium predict cognitive decline among elderly patients with diabetes mellitus: The Japanese Elderly Diabetes Intervention Trial.
Melatonin ameliorates neurologic damage and neurophysiologic deficits in experimental models of stroke.
Metabolic stroke in carbamyl phosphate synthetase deficiency.
Protective effects of 5-iodo-6-amino-1,2-benzopyrone, an inhibitor of poly(ADP-ribose) synthetase against peroxynitrite-induced glial damage and stroke development.
Role of poly(ADP-ribose) synthetase in inflammation and ischaemia-reperfusion.
Stuttering
The Case of a Patient with Pantothenate Kinase-Associated Neurodegeneration Presenting with a Prolonged History of Stuttering Speech and a Misdiagnosis of Parkinson's Disease.
Subarachnoid Hemorrhage
Effects of subarachnoid hemorrhage on platelet-derived vasoconstriction of rabbit basilar artery.
Efficacy and toxicity of thromboxane synthetase inhibitor for cerebral vasospasm after subarachnoid hemorrhage.
Thromboxane A2 synthetase inhibitor failed to ameliorate the arterial narrowing during the chronic phase of cerebral vasospasm.
Supranuclear Palsy, Progressive
Neuropareidolia: diagnostic clues apropos of visual illusions.
Synucleinopathies
Neuropathology and pathogenesis of extrapyramidal movement disorders: a critical update-I. Hypokinetic-rigid movement disorders.
Pantothenate kinase-associated neurodegeneration is not a synucleinopathy.
Update on neurodegeneration with brain iron accumulation.
Tardive Dyskinesia
Deep brain stimulation for dystonia: a meta-analysis.
Neuromodulation in dystonia: current aspects of deep brain stimulation.
Severe tongue protrusion dystonia: clinical syndromes and possible treatment.
Surgery for other movement disorders: dystonia, tics.
Tongue Protrusion Dystonia in Pantothenate Kinase-Associated Neurodegeneration.
Tauopathies
Neuropathology and pathogenesis of extrapyramidal movement disorders: a critical update-I. Hypokinetic-rigid movement disorders.
Telangiectasis
Dermatomyositis: an association of gingival telangiectases and anti Jo-1 antibody in the adult.
Tetanus
Postimmunization activity of oligoadenylate synthetase in peripheral blood lymphocytes from healthy individuals.
Thalassemia
First report of co-morbidity of pantothenate kinase-associated neurodegeneration and three types of chronic hemolytic anemias.
Thromboembolism
Effect of thromboxane synthetase inhibitors (OKY-046, OKY-1580) on experimentally induced air embolism in anesthetized dogs.
Thrombosis
Arachidonic acid metabolites, ADP and thrombin modulate occlusive thrombus formation over extensive arterial injury in the rat.
Dual inhibition of thromboxane A2 synthesis and thromboxane A2/prostaglandin endoperoxide receptors by ridogrel: anti-thrombotic effect in vivo in rat mesenteric arteries.
Effect of antithrombotic agents after carotid endarterectomy in rats.
Effects of a thromboxane A2-receptor antagonist, a thromboxane synthetase inhibitor and aspirin on prostaglandin I2 production in endothelium-intact and -injured aorta of guinea pigs.
Endogenous and exogenous nitric oxide protect against intracoronary thrombosis and reocclusion after thrombolysis.
Photochemically induced thrombosis of the rat coronary artery and functional evaluation of thrombus formation by occurrence of ventricular arrhythmias. Effects of acetylsalicylic acid and a thromboxane A2 synthetase inhibitor of thrombus formation.
The role of thromboxane (TX) A2 in rabbit arterial thrombosis induced by endothelial damage.
Thyroid Diseases
Correlation between HLA-DR expression and level of poly(ADP-ribose) synthetase in human thyroid carcinoma cells.
Thyroid Neoplasms
Analysis of 2'5' oligo (A) synthetase in patients with advanced thyroid carcinoma.
Correlation between HLA-DR expression and level of poly(ADP-ribose) synthetase in human thyroid carcinoma cells.
Decreased expression of TNFRSF12A in thyroid gland cancer predicts poor prognosis: A study based on TCGA data.
Tourette Syndrome
Pantothenate kinase-associated neurodegeneration mimicking Tourette syndrome: a case report and review of the literature.
Tremor
Novel PANK2 gene mutations in korean patient with pantothenate kinase-associated neurodegeneration presenting unilateral dystonic tremor.
Pantothenate kinase-associated neurodegeneration initially presenting as postural tremor alone in a Japanese family with homozygous N245S substitutions in the pantothenate kinase gene.
Partial deficit of pantothenate kinase 2 catalytic activity in a case of tremor-predominant neurodegeneration with brain iron accumulation.
Tremor-Dominant Pantothenate Kinase-associated Neurodegeneration.
Tuberculosis
5-tert-Butyl-N-pyrazol-4-yl-4,5,6,7-tetrahydrobenzo[d]isoxazole-3-carboxamide Derivatives as Novel Potent Inhibitors of Mycobacterium tuberculosis Pantothenate Synthetase: Initiating a Quest for New Antitubercular Drugs.
A comparison of the dynamics of pantothenate synthetase from M. tuberculosis and E. coli: Computational studies.
A discovery of novel Mycobacterium tuberculosis pantothenate synthetase inhibitors based on the molecular mechanism of actinomycin D inhibition.
A eubacterial Mycobacterium tuberculosis tRNA synthetase is eukaryote-like and resistant to a eubacterial-specific antisynthetase drug.
A Fragment-Based Approach to Probing Adenosine Recognition Sites by Using Dynamic Combinatorial Chemistry.
A high-throughput screen against pantothenate synthetase (PanC) identifies 3-biphenyl-4-cyanopyrrole-2-carboxylic acids as a new class of inhibitor with activity against Mycobacterium tuberculosis.
A novel inhibitor of Mycobacterium tuberculosis pantothenate synthetase.
A novel mycolic acid cyclopropane synthetase is required for cording, persistence, and virulence of Mycobacterium tuberculosis.
A pantothenate auxotroph of Mycobacterium tuberculosis is highly attenuated and protects mice against tuberculosis.
Active site residues in Mycobacterium tuberculosis pantothenate synthetase required in the formation and stabilization of the adenylate intermediate.
Alanine mutation of the catalytic sites of Pantothenate Synthetase causes distinct conformational changes in the ATP binding region.
Application of Fragment Growing and Fragment Linking to the Discovery of Inhibitors of Mycobacterium tuberculosis Pantothenate Synthetase.
Attenuation of Mycobacterium tuberculosis functionally disrupted in a fatty acyl-coenzyme A synthetase gene fadD5.
Binding of pyrazole-based inhibitors to Mycobacterium tuberculosis pantothenate synthetase: docking and MM-GB(PB)SA analysis.
Chemoinformatic identification of novel inhibitors against Mycobacterium tuberculosis L-aspartate ?-decarboxylase.
Crystal Structure of the Pantothenate Synthetase from Mycobacterium tuberculosis, Snapshots of the Enzyme in Action(,).
Crystal structures of a pantothenate synthetase from M. tuberculosis and its complexes with substrates and a reaction intermediate.
Design of Novel Mycobacterium tuberculosis Pantothenate Synthetase Inhibitors: Virtual Screening, Synthesis and In Vitro Biological Activities.
Design, synthesis and biological evaluation of imidazo[2,1-b]thiazole and benzo[d]imidazo[2,1-b]thiazole derivatives as Mycobacterium tuberculosis pantothenate synthetase inhibitors.
Development of 3-phenyl-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine derivatives as novel Mycobacterium tuberculosis pantothenate synthetase inhibitors.
Development of novel tetrahydrothieno[2,3-c]pyridine-3-carboxamide based Mycobacterium tuberculosis pantothenate synthetase inhibitors: Molecular hybridization from known antimycobacterial leads.
Different ways to transport ammonia in human and Mycobacterium tuberculosis NAD+ synthetases.
Essential roles for Mycobacterium tuberculosis Rel beyond the production of (p)ppGpp.
Essentiality and functional analysis of type I and type III pantothenate kinases of Mycobacterium tuberculosis.
Extended safety and efficacy studies of a live attenuated double leucine and pantothenate auxotroph of Mycobacterium tuberculosis as a vaccine candidate.
Failure of a Mycobacterium tuberculosis DeltaRD1 DeltapanCD double deletion mutant in a neonatal calf aerosol M. bovis challenge model: Comparisons to responses elicited by M. bovis bacille Calmette Guerin.
Heat-stable stimulating factor for fatty acid synthetase from Mycobacterium tuberculosis H37Rv.
Heterologous expression, purification, and enzymatic activity of Mycobacterium tuberculosis NAD(+) synthetase.
High throughput screening against pantothenate synthetase identifies amide inhibitors against Mycobacterium tuberculosis and Staphylococcus aureus.
How pantothenol intervenes in Coenzyme-A biosynthesis of Mycobacterium tuberculosis.
Identification and development of 2-methylimidazo[1,2-a]pyridine-3-carboxamides as Mycobacterium tuberculosis pantothenate synthetase inhibitors.
Identification of a Mycobacterium tuberculosis gene cluster encoding the biosynthetic enzymes for assembly of the virulence-conferring siderophore mycobactin.
Inhibition of Mycobacterium tuberculosis pantothenate synthetase by analogues of the reaction intermediate.
Inositol-1-phosphate synthetase mRNA as a new target for antisense inhibition of Mycobacterium tuberculosis.
Integrated biophysical approach to fragment screening and validation for fragment-based lead discovery.
Location and conformation of pantothenate and its derivatives in Mycobacterium tuberculosis pantothenate kinase: insights into enzyme action.
Long-term protection against tuberculosis following vaccination with a severely attenuated double lysine and pantothenate auxotroph of Mycobacterium tuberculosis.
M. tuberculosis pantothenate kinase: dual substrate specificity and unusual changes in ligand locations.
Modular approach to triazole-linked 1,6-?-d-oligomannosides to the discovery of inhibitors of Mycobacterium tuberculosis cell wall synthetase.
Mycobacterium avium genes associated with the ability to form a biofilm.
Mycobacterium tuberculosis DeltaRD1 DeltapanCD: a safe and limited replicating mutant strain that protects immunocompetent and immunocompromised mice against experimental tuberculosis.
Mycobacterium tuberculosis PanD Structure-Function Analysis and Identification of a Potent Pyrazinoic Acid-Derived Enzyme Inhibitor.
Mycobacterium tuberculosis pantothenate kinase: possible changes in location of ligands during enzyme action.
Mycobacterium tuberculosis Phe-tRNA synthetase: structural insights into tRNA recognition and aminoacylation.
Optimization of Inhibitors of Mycobacterium tuberculosis Pantothenate Synthetase Based on Group Efficiency Analysis.
Optimization of the interligand overhauser effect for fragment linking: application to inhibitor discovery against Mycobacterium tuberculosis pantothenate synthetase.
Pantothenate and pantetheine antagonize the antitubercular activity of pyrazinamide.
Pantothenic acid biosynthesis in the parasite Toxoplasma gondii: a target for chemotherapy.
Positional isotope exchange analysis of the pantothenate synthetase reaction.
Protection elicited by a double leucine and pantothenate auxotroph of Mycobacterium tuberculosis in guinea pigs.
Pyrazinamide inhibits the eukaryotic-like fatty acid synthetase I (FASI) of Mycobacterium tuberculosis.
Quinolidene based monocarbonyl curcumin analogues as promising antimycobacterial agents: Synthesis and molecular docking study.
Rational Design of Biosafety Level 2-Approved, Multidrug-Resistant Strains of Mycobacterium tuberculosis through Nutrient Auxotrophy.
Reconstitution of Protein Translation of Mycobacterium Reveals Functional Conservation and Divergence with the Gram-Negative Bacterium Escherichia coli.
Regulation of active site coupling in glutamine-dependent NAD(+) synthetase.
Restoration of mycolate synthetase activity in Mycobacterium tuberculosis exposed to isoniazid.
Site of inhibitory action of isoniazid in the synthesis of mycolic acids in Mycobacterium tuberculosis.
Steady-state and pre-steady-state kinetic analysis of Mycobacterium tuberculosis pantothenate synthetase.
Structural and biochemical characterization of compounds inhibiting Mycobacterium tuberculosis pantothenate kinase.
Structure-guided design of thiazolidine derivatives as Mycobacterium tuberculosis pantothenate synthetase inhibitors.
Susceptibility and mode of binding of the Mycobacterium tuberculosis cysteinyl transferase mycothiol ligase to tRNA synthetase inhibitors.
Synthesis, in vitro antimycobacterial evaluation and docking studies of some new 5,6,7,8-tetrahydropyrido[4',3':4,5]thieno[2,3-d]pyrimidin-4(3H)-one schiff bases.
Targeting Mycobacterium tuberculosis CoaBC through Chemical Inhibition of 4'-Phosphopantothenoyl-l-cysteine Synthetase (CoaB) Activity.
The crystal structure of the first enzyme in the pantothenate biosynthetic pathway, ketopantoate hydroxymethyltransferase, from M tuberculosis.
The MM2QM tool for combining docking, molecular dynamics, molecular mechanics, and quantum mechanics†.
The Mycobacterium tuberculosis cmaA2 gene encodes a mycolic acid trans-cyclopropane synthetase.
Validation of CoaBC as a Bactericidal Target in the Coenzyme A Pathway of Mycobacterium tuberculosis.
[Acetylation processes during the treatment of tuberculosis with antibacterial preparations and calcium pantothenate.]
[Advantages of streptomycin pantothenate in tuberculosis in subjects with an intolerance or resistance to streptomycin.]
[Calcium pantothenate in clinical tuberculosis in the presence of side effects of streptomycin.]
[Clinico-experimental studies on dihydrostreptomycin pantothenate in tuberculosis.]
[Dihydrostreptomyin pantothenate in the treatment of tuberculosis.]
[Experience with the use of dihydrostreptomycin pantothenate in the treatment of tuberculosis.]
[On the tolerance for a combination of dihydrostreptomycin pantothenate and dihydrostreptomycin sulfate in the therapy of tuberculosis with particular reference to the therapy of tuberculous meningitis.]
[Role of calcium pantothenate in vitamin B requirement of children with tuberculosis]
[THE EFFECT OF CALCIUM PANTOTHENATE ON THE EFFECTIVENESS OF ANTIBACTERIAL THERAPY OF EXPERIMENTAL TUBERCULOSIS.]
[The treatment of tuberculosis with PAS-streptomycin pantothenate in venous perfusion.]
[Value of dihydrostreptomycin pantothenate in the prevention of accidents during intensive treatment of tuberculosis.]
[Viomycin pantothenate in therapy-resistant primary tuberculosis in small children.]
Tuberculosis, Meningeal
[On the tolerance for a combination of dihydrostreptomycin pantothenate and dihydrostreptomycin sulfate in the therapy of tuberculosis with particular reference to the therapy of tuberculous meningitis.]
Tuberculosis, Pulmonary
The pantothenate of streptomycin in the treatment of pulmonary tuberculosis.
[Combined treatment of pulmonary tuberculosis with DSM pantothenate, INH and PAS in continuous infusion.]
[Dihydrostreptomycin pantothenate & its tolerance in the treatment of pulmonary tuberculosis.]
[The effect of combined streptomycin pantothenate and INH therapy on the otovestibular system in chronic pulmonary tuberculosis patients.]
[Value & tolerance of dihydrostreptomycin pantothenate in the treatment of pulmonary tuberculosis.]
[Viomycin and viomycin pantothenate with reduced toxicity in therapy of pulmonary tuberculosis.]
unspecific monooxygenase deficiency
Disorders of phospholipids, sphingolipids and fatty acids biosynthesis: toward a new category of inherited metabolic diseases.
Urea Cycle Disorders, Inborn
Alteration of urinary carnitine profile induced by benzoate administration.
The allopurinol load test lacks specificity for primary urea cycle defects but may indicate unrecognized mitochondrial disease.
Urinary Bladder Neoplasms
Identification of bladder cancer antigens recognized by IgG antibodies of a patient with metastatic bladder cancer.
[The effect of different types of recombinant interferon on the induction of 2,5-oligoadenylate synthetase in natural killers and the tumor cells in bladder cancer patients]
Uterine Cervical Neoplasms
Genetic variations in the SULF1 gene alter the risk of cervical cancer and precancerous lesions.
Poly(ADP-ribose) synthesis in human cervical cancer cell-diagnostic cytological usefulness.
Uterine Cervicitis
An integrative investigation of the therapeutic mechanism of Ainsliaea fragrans Champ. in cervicitis using liquid chromatography tandem mass spectrometry based on a rat plasma metabolomics strategy.
Uveomeningoencephalitic Syndrome
Oligo-2',5'-adenylate synthetase activity in peripheral blood mononuclear leukocytes in various diseases.
Vaccinia
Classification, diagnosis and potential mechanisms in Pontocerebellar Hypoplasia.
Vaccinia-mediated rescue of encephalomyocarditis virus from the inhibitory effects of interferon.
Vaginal Discharge
Identification of viral infections in pregnancy by assay of (2'-5')-oligo-isoadenylate synthetase.
Vasculitis
Effect of thromboxane synthetase inhibitor on feline infectious peritonitis in cats.
Vasospasm, Intracranial
Beneficial effect of OKY-046, a selective thromboxane A2 synthetase inhibitor, on experimental cerebral vasospasm.
Effects of thromboxane synthetase inhibitor (RS-5186) on experimentally-induced cerebral vasospasm.
Efficacy and toxicity of thromboxane synthetase inhibitor for cerebral vasospasm after subarachnoid hemorrhage.
Thromboxane A2 synthetase inhibitor failed to ameliorate the arterial narrowing during the chronic phase of cerebral vasospasm.
Vertigo
[Preliminary note on the effects of sodium pantothenate in vertigo.]
Vesicular Stomatitis
An interferon-induced cellular enzyme is incorporated into virions.
Biochemical analysis of mutants of a macrophage cell line resistant to the growth-inhibitory activity of interferon.
Biologic response (antiviral) to recombinant human interferon alpha 2a as a function of dose and route of administration in healthy volunteers.
Cloning, sequencing, and expression of two murine 2'-5'-oligoadenylate synthetases. Structure-function relationships.
Induction by vasoactive intestinal peptide of interferon alpha/beta synthesis in glial cells but not in neurons.
Induction of an antiviral state by interferon in the absence of elevated levels of 2,5-oligo(A) synthetase and eIF-2 kinase.
Inhibition of mouse fibroblast interferon by gangliosides. Differential effects on biological activity and on induction of (2'--5')oligoadenylate synthetase.
Possible involvement of virus-induced protein kinase in the antiviral state induced with interferon-gamma against Sindbis virus.
Time course of interferon levels, antiviral state, 2',5'-oligoadenylate synthetase and side effects in healthy men.
[Vasoactive intestinal peptide induces 2',5'-oligoadenylate synthetase and antiviral state in cells of HT-29 colonic cancer]
Viremia
Altered tissue distribution of viral replication and T cell spreading is pivotal in the protection against fatal lymphocytic choriomeningitis in mice after neutralization of IFN-alpha/beta.
Virus Diseases
(2'-5') Oligo A synthetase in human polymorphonuclear cells increased activity in interferon treatment and in viral infections.
(2'-5') oligo adenylate synthetase activity in leucocytes of patients with inflammatory bowel disease.
A phenolic small molecule inhibitor of RNase L prevents cell death from ADAR1 deficiency.
Basal and interferon-induced 2',5'-oligoadenylate synthetase in human monocytes, lymphocytes, and peritoneal macrophages.
Biologic response (antiviral) to recombinant human interferon alpha 2a as a function of dose and route of administration in healthy volunteers.
Common Genetic Variants and Risk for HPV Persistence and Progression to Cervical Cancer.
Comparison of (2'-5') oligo-adenylate synthetase and interferon blood-levels in mice early after viral infection.
Diagnostic evaluation of 2', 5'-oligoadenylate synthetase activities and antibodies against Epstein-Barr virus and Coxiella burnetii in patients with chronic fatigue syndrome in Japan.
Distribution of immunoreactive 2',5'-oligoadenylate synthetase in mouse reproductive organs.
Evidence from twins for acquired cellular immune hyperactivity in type 1 diabetes.
Functional evolution of the OAS1 viral sensor: Insights from old world primates.
Identification of viral infections in pregnancy by assay of (2'-5')-oligo-isoadenylate synthetase.
Immunity to West Nile virus.
Indomethacin enhances serum 2'5'-oligoadenylate synthetase in patients with hepatitis B and C virus chronic active hepatitis.
Induction and measurement of 2',5'-oligoadenylate synthetase in Madin-Darby bovine kidney cells and in cattle.
Induction of gene expression by intracellular interferon-gamma: abrogation of the species specificity barrier.
Induction of OAS gene family in HIV monocyte infected patients with high and low viral load.
Infection of mouse neurones by West Nile virus is modulated by the interferon-inducible 2'-5' oligoadenylate synthetase 1b protein.
Interferon cures cells lytically and persistently infected with African swine fever virus in vitro.
Interferon stimulates the expression of 2',5'-oligoadenylate synthetase and MHC class I antigens in insulin-producing cells.
Lanthionine Synthetase C-Like 2 Modulates Immune Responses to Influenza Virus Infection.
Length dependent activation of OAS proteins by dsRNA.
Loss of (2'-5')oligoadenylate synthetase activity by production of antisense RNA results in lack of protection by interferon from viral infections.
Molecular Mechanisms for the Adaptive Switching Between the OAS/RNase L and OASL/RIG-I Pathways in Birds and Mammals.
Murine pancreatic beta TC3 cells show greater 2', 5'-oligoadenylate synthetase (2'5'AS) antiviral enzyme activity and apoptosis following IFN-alpha or poly(I:C) treatment than pancreatic alpha TC3 cells.
OAS1 and OAS3 negatively regulate the expression of chemokines and interferon-responsive genes in human macrophages.
OASL1 Traps Viral RNAs in Stress Granules to Promote Antiviral Responses.
Polymorphisms in the oligoadenylate synthetase gene cluster and its association with clinical outcomes of dengue virus infection.
RNase L restricts the mobility of engineered retrotransposons in cultured human cells.
The role of mouse 2',5'-oligoadenylate synthetase 1 paralogs.
Variation of (2'-5') oligo A synthetase level in lymphocytes and granulocytes of patients with viral infections and leukemia.
Viral phosphodiesterases that antagonize double-stranded RNA signaling to RNase L by degrading 2-5A.
[Early diagnosis of central nervous system (CNS) viral infections in the neonatal period and early infancy]
Vision Disorders
Congenital Visual Impairment and Progressive Microcephaly Due to Lysyl-Transfer Ribonucleic Acid (RNA) Synthetase (KARS) Mutations: The Expanding Phenotype of Aminoacyl-Transfer RNA Synthetase Mutations in Human Disease.
Vitamin A Deficiency
[Retinol-palmitate synthetase and retinol-palmitate hydrolase activity in small intestine mucosa and mucosal cell membranes in vitamin A deficiency and exposure to ionizing radiation]
Vitamin B 12 Deficiency
Effects of the disruption of transmethylation in the central nervous system: an animal model.
[Effect of pantothenate on indices related to cobalamin metabolism in vitamin B 12 deficiency]
Vitamin B 6 Deficiency
Hydrogen sulphide production by yeast under conditions of methionine, pantothenate or vitamin B6 deficiency.
[Effect of pyridoxine deficiency on fatty acid metabolism in the rat]
Vocal Cord Dysfunction
Pantothenate kinase-associated neurodegeneration causing paradoxical vocal fold motion.
West Nile Fever
Infection of mouse neurones by West Nile virus is modulated by the interferon-inducible 2'-5' oligoadenylate synthetase 1b protein.
Whooping Cough
[Treatment of whooping cough with mixture of streptomycin pantothenate and dihydrostreptomycin.]
Yellow Fever
Postimmunization activity of oligoadenylate synthetase in peripheral blood lymphocytes from healthy individuals.
Zellweger Syndrome
Beta-oxidation of very-long-chain fatty acids and their coenzyme A derivatives by human skin fibroblasts.