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BRENDA support

Information on EC 6.3.1.22 - tRNAmet cytidine acetate ligase

for references in articles please use BRENDA:EC6.3.1.22

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IUBMB Comments

The enzyme, charactrized from the bacterium Bacillus subtilis, catalyses a similar tRNA modification to that performed by EC 2.3.1.193, tRNAMet cytidine acetyltransferase. However, unlike that enzyme, which uses acetyl-CoA as the acetyl donor, this enzyme activates an acetate ion to form acetyladenylate and then catalyses the acetylation through a mechanism similar to tRNA aminoacylation.

The expected taxonomic range for this enzyme is: Bacillus subtilis
Reaction Schemes
hide(Overall reactions are displayed. Show all >>)
+
[elongator tRNAMet]-cytidine34
+
=
+
+
[elongator tRNAMet]-N4-acetylcytidine34

Synonyms
tmcAL, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
acetyladenylate + [elongator tRNAMet]-cytidine34 = AMP + [elongator tRNAMet]-N4-acetylcytidine34
show the reaction diagram
(1b)
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-
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ATP + acetate = acetyladenylate + diphosphate
show the reaction diagram
(1a)
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-
-
ATP + [elongator tRNAMet]-cytidine34 + acetate = AMP + diphosphate + [elongator tRNAMet]-N4-acetylcytidine34
show the reaction diagram
overall reaction
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