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Information on EC 6.3.1.14 - diphthine-ammonia ligase

for references in articles please use BRENDA:EC6.3.1.14
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IUBMB Comments
This amidase catalyses the last step in the conversion of an L-histidine residue in the translation elongation factor EF2 to diphthamide. This factor is found in all archaea and eukaryota, but not in eubacteria, and is the target of bacterial toxins such as the diphtheria toxin and the Pseudomonas exotoxin A (see EC 2.4.2.36, NAD+---diphthamide ADP-ribosyltransferase). The substrate of the enzyme, diphthine, is produced by EC 2.1.1.98, diphthine synthase.
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The enzyme appears in viruses and cellular organisms
Synonyms
Diphthamide synthase, diphthamide synthetase, DPH6, Synthetase, diphthamide, YLR143w, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
ATP + diphthine-[translation elongation factor 2] + NH3 = AMP + diphosphate + diphthamide-[translation elongation factor 2]
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