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BRENDA support

Information on EC 6.2.1.76 - malonate-CoA ligase

for references in articles please use BRENDA:EC6.2.1.76

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IUBMB Comments

The enzyme, found in mitochondria, detoxifies malonate, which is a potent inhibitor of mitochondrial respiration, and provides malonyl-CoA to the mitochondrial fatty acid biosynthesis pathway.

The expected taxonomic range for this enzyme is: Eukaryota, Bacteria

Synonyms
acsf3, malonyl-coa synthetase, aae13, acyl activating enzyme13, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
ATP + malonate + CoA = AMP + diphosphate + malonyl-CoA
show the reaction diagram
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PATHWAY SOURCE
PATHWAYS
MetaCyc
fatty acid biosynthesis initiation (mitochondria), fatty acid biosynthesis initiation (plant mitochondria)
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